EC Number   |
Natural Substrates |
|---|
   3.1.3.48 | DADE(pY)LIPQQG + H2O |
a physiological phosphopeptide substrate of enzyme PTP1B |
| 3.1.3.48 | FMN + H2O |
lung enzyme |
| 3.1.3.48 | more |
the isoforms of PRP36 may function as adapter molecules rather than as a phosphatase |
| 3.1.3.48 | more |
PTPases regulate the ligand-induced autophosphorylation of PTK growth factor receptors, the phosphotyrosine-mediated binding s of src homology 2 (SH2)-domain-containing proteins to autophosphorylated PTK growth factor receptors and the activation state of the src family pf PTK |
| 3.1.3.48 | more |
LMW-PTP is involved in the negative regulation of the mitogenic stimulus starting from the activated PDGF receptor. The interaction between LMW-PTP results in the dephosphorylation of the PDGF-R phosphortyrosine and a negative regulation of the mitogenic signal |
| 3.1.3.48 | more |
protein-tyrosine phosphatases are signaling molecules that are involved in numerous cellular mechanisms such as cell growth and proliferation, cell cycle regulation, and cytoskeletal integrity |
| 3.1.3.48 | more |
essential for virulence of the bacteria responsible for the plague |
| 3.1.3.48 | more |
LAR, PTPalpha and PTP1B may act upon cell surface insulin receptors |
| 3.1.3.48 | more |
physiological substrates, overview |
| 3.1.3.48 | more |
possible specific substrate is p190Rho-GAP |
