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EC Number
Inhibitors
Commentary
Structure
1.5.1.39
AMP
competitive inhibition against NADH and uncompetitive inhibition against FMN
1.5.1.39
Co2+
slight inhibition
1.5.1.39
Fe3+
slight inhibition
1.5.1.39
lumichrome
7,8-dimethylalloxazine, competitive inhibitor versus FMN, and mixed noncompetitive inhibitor with respect to NADH
1.5.1.39
Mg2+
slight inhibition
1.5.1.39
more
the substrate binding order is investigated by carrying out dead-end inhibition studies using lumichrome (7,8-dimethylalloxazine) and AMP as inhibitory analogues of FMN and NADH. Strains Pd9233 and Pd9311 contain aa3-type or cbb3-type cytochrome c oxidase, respectively, as the only terminal oxidase of the respiratory electron transfer chain, the flux capacity through terminal oxidase is reduced in strain Pd9311 compared to strain Pd9233 or wild-type strain, manifested by the much lower specific activity of TMPD oxidase found in the cytoplasmic membrane fraction. The pden_5119 transcript in Pd9311 cells but not in Pd9233 cells is elevated similarly as observed in the wild-type strain growing in the presence of electron transfer inhibitors. Downregulation of terminal oxidase thus indeed results in a similar outcome as chemical inhibition
1.5.1.39
Triton X-10
slight inhibition
1.5.1.39
Tween 80
slight inhibition
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