EC Number   |
Recommended Name   |
Amino acid exchange   |
Commentary   |
Organism   |
Primary Accession No.   |
Reference   |
1.2.1.24 |
succinate-semialdehyde dehydrogenase (NAD+) |
1.2.1.24 |
R166A |
the mutant enzyme shows no activity towards acetaldehyde and decreased activity and higher KM for succinate semiacetaldehyde |
Rattus norvegicus |
- |
697282 |
1.2.1.24 |
succinate-semialdehyde dehydrogenase (NAD+) |
1.2.1.24 |
R166E |
the mutant enzyme shows almost no activity towards acetaldehyde and decreased activity and higher KM for succinate semiacetaldehyde |
Rattus norvegicus |
- |
697282 |
1.2.1.24 |
succinate-semialdehyde dehydrogenase (NAD+) |
1.2.1.24 |
R166H |
the mutant has KM for succinate semiacetaldehyde of 800fold greater than the wild type enzyme, while the VMAX for this mutant is 11.3fold less than wild type for succinate semiacetaldehyde |
Rattus norvegicus |
- |
697282 |
1.2.1.24 |
succinate-semialdehyde dehydrogenase (NAD+) |
1.2.1.24 |
R166K |
the mutant has KM for succinate semiacetaldehyde of 8fold greater than the wild type enzyme, while the VMAX for this mutant is 2.5fold less than wild type for succinate semiacetaldehyde |
Rattus norvegicus |
- |
697282 |