Information on EC 5.4.2.1 - phosphoglycerate mutase:
   PRINT
Please wait a moment until all data are loaded. This message will disappear when all data are loaded.
Mark a special word or phrase in this record:  
Select one or more organisms in this record:

Show additional data Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

Please login to have access to the AMENDA and FRENDA data

EC NUMBERCOMMENTARY
5.4.2.1-

RECOMMENDED NAMEGeneOntology No.
phosphoglycerate mutaseGO:0046538

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
2-Phospho-D-glycerate = 3-phospho-D-glycerate
show the reaction diagram		----
2-Phospho-D-glycerate = 3-phospho-D-glycerate
show the reaction diagram		mechanism: after the active site His-8 is phosphorylated by the cofactor 2,3-diphosphoglycerate a substrate molecule binds. Subsequently a phospho-transfer takes place via a ping-pong-mechanism. After release of the product the enzyme remains phosphorylated and catalytically competentSaccharomyces cerevisiae-3231
2-Phospho-D-glycerate = 3-phospho-D-glycerate
show the reaction diagram		ping-pong mechanism via a phosphorylated His-intermediateOryctolagus cuniculus, Saccharomyces cerevisiae-3240
2-Phospho-D-glycerate = 3-phospho-D-glycerate
show the reaction diagram		ping-pong or phosphoenzyme mechanismHomo sapiens-661261
2-Phospho-D-glycerate = 3-phospho-D-glycerate
show the reaction diagram		in the phospho-D-glycerate-free state the enzyme assumes an open conformation. Upon substrate binding the enzyme closes to the catalytically functional conformation, in the closed form the enzyme catalyzes 2/3-phospho-D-glycerate isomerization resulting in product release. Product release causes opening of the enzyme and return to the open conformationBacillus anthracisQ81X77678734

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
intramolecular isomerization----
intramolecular phosphate transfer----
isomerization----

PATHWAYKEGG LinkMetaCyc Link
1-butanol autotrophic biosynthesis-PWY-6886
Bifidobacterium shunt-P124-PWY
Entner-Doudoroff pathway III (semi-phosphorylative)-PWY-2221
formaldehyde assimilation I (serine pathway)-PWY-1622
gluconeogenesis I-GLUCONEO-PWY
gluconeogenesis II (Methanobacterium thermoautotrophicum)-PWY-6142
glycerol degradation to butanol-PWY-7003
glycolysis I-GLYCOLYSIS
glycolysis II (from fructose-6P)-PWY-5484
glycolysis III (glucokinase)-ANAGLYCOLYSIS-PWY
glycolysis IV (plant cytosol)-PWY-1042
glycolysis V (Pyrococcus)-P341-PWY
heterolactic fermentation-P122-PWY
Rubisco shunt-PWY-5723
xylose degradation IV-PWY-6901

SYSTEMATIC NAMEIUBMB Comments
D-Phosphoglycerate 2,3-phosphomutaseThe enzymes from mammals and from yeast are phosphorylated by (2R)-2,3-bis-phosphoglycerate, which is also an intermediate (see introduction to section EC 5.4.2). With the rabbit muscle enzyme, dissociation of bisphosphate from the enzyme is much slower than the overall isomerization. These enzymes also catalyse, slowly, the reactions of EC 5.4.2.4 bisphosphoglycerate mutase; they were formerly listed as EC 2.7.5.3. Enzymes from wheat, rice, insects and some fungi, however, have maximum activity in the absence of 2,3-bisphosphoglycerate, and were formerly listed under the present number as phosphoglycerate phosphomutase.

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
2,3-diphosphoglycerate-independent phosphoglycerate mutaseSulfolobus solfataricusQ980A0-651716
2,3BPG-independent PGAMUstilago maydis--692403
3-phosphoglycerate mutaseUstilago maydis--692403
aPGAM----
aPGAM-Mj1----
aPGAM-Mj2----
B-type PGMHomo sapiens--706661
BPG-dependent PGAM----
BPG-independent PGAM----
cofactor-dependent phosphoglycerate mutaseEscherichia coli--652877
cofactor-independent phosphoglycerate mutase 1Leishmania mexicana--705169
DPGM----
DPGMEscherichia coli--652877
DPGMLactococcus lactis subsp. lactis--715964
dPGM-BHomo sapiens--706661
EntDMycobacterium tuberculosis--660633
Glycerate phosphomutase (diphosphoglycerate cofactor)----
GriP mutase----
independent PGMDirofilaria immitisF4ZE01the enzyme requires 2,3-bisphosphoglycerate as a cofactor716984
independent PGMWolbachia sp.F4ZE02the enzyme requires 2,3-bisphosphoglycerate as a cofactor716984
iPGAMLeishmania mexicanaQ86N96-649202, 705169
iPGAMTrypanosoma bruceiQ9NG18-651058
iPGM----
iPGMGeobacillus stearothermophilus--650970, 652915
iPGMMethanocaldococcus jannaschii-i.e. 2,3-bisphosphoglycerate independent phosphoglycerate mutase651372
iPGMPyrococcus furiosus-i.e. cofactor independent phosphoglycerate mutase651372
iPGMWolbachia sp.Q5GSN3-694538
iPGMDirofilaria immitisF4ZE01the enzyme requires 2,3-bisphosphoglycerate as a cofactor716984
iPGMWolbachia sp.F4ZE02the enzyme requires 2,3-bisphosphoglycerate as a cofactor716984
Monophosphoglycerate mutase----
Monophosphoglyceromutase----
MPGM----
Muscle-specific phosphoglycerate mutase----
PGA mutase----
PGAM----
PGAMSaccharomyces cerevisiae--649656, 652790, 652799
PGAMSchizosaccharomyces pombe--649656, 652799, 652846
PGAMUstilago maydis--692403
PGAM-d----
PGAM-i----
PGAM1Rattus norvegicus--694050, 705270
PGAM1Mus musculus--703862
PGAM1Homo sapiens--705672
PGAM2Sus scrofaB5KJG2, B5KJG3muscle-specific isoform; muscle-specific isoform693442
PGM----
PGMBacillus subtilis, Clostridium perfringens, Micrococcus luteus, Planococcus citreus, Sporosarcina ureae, Staphylococcus saprophyticus, Streptomyces coelicolor--650753
PGMGeobacillus stearothermophilus--653052
PGMOryctolagus cuniculus, Rattus norvegicus--703707
PGMHomo sapiens--706661
PGMLactococcus lactis subsp. lactis--715964
PGMDirofilaria immitisF4ZE01-716984
PGMWolbachia sp.F4ZE02-716984
PH0037Pyrococcus horikoshii--677357
phosphoglycerate mutaseOryctolagus cuniculus, Rattus norvegicus--703707
phosphoglycerate mutaseHomo sapiens--706661
phosphoglycerate mutase 1Mus musculus--690732, 703862
phosphoglycerate mutase 1Rattus norvegicus--705270
phosphoglycerate mutase 1Homo sapiens--705672
phosphoglycerate mutase type BRattus norvegicus--694050
Phosphoglycerate phosphomutase----
Phosphoglyceromutase----
Phosphomutase, glycerate----
Rv3214Mycobacterium tuberculosis--660633
ScPGMSaccharomyces cerevisiae--649101
Sts-1Mus musculus--677393
VEG107----
Vegetative protein 107----

CAS REGISTRY NUMBERCOMMENTARY
9023-91-0-
9032-62-6-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Archaeoglobus fulgiduscofactor-independent isoform679715--Manually annotated by BRENDA team
Bacillus anthracis-678734Q81X77SwissProtManually annotated by BRENDA team
Bacillus megaterium-3224, 3239, 3249, 677798--Manually annotated by BRENDA team
Bacillus subtilis-3239, 3249, 3250, 650753--Manually annotated by BRENDA team
Bos taurusbovine3235--Manually annotated by BRENDA team
Brugia malayi-662259Q4VWF8UniprotManually annotated by BRENDA team
Caenorhabditis elegans-662259G5EFZ1UniprotManually annotated by BRENDA team
Clostridium perfringens-650753--Manually annotated by BRENDA team
Cyberlindnera jadinii-3239--Manually annotated by BRENDA team
Dirofilaria immitis-716984F4ZE01UniProtManually annotated by BRENDA team
Emericella nidulans-3238--Manually annotated by BRENDA team
Entamoeba histolytica-661689--Manually annotated by BRENDA team
Enterobacter aerogenes-3239--Manually annotated by BRENDA team
Escherichia coli-3239, 3260, 652877--Manually annotated by BRENDA team
Gallus gallus-3213, 3214, 3258--Manually annotated by BRENDA team
Geobacillus stearothermophilus-650970, 653052Q9X519SwissProtManually annotated by BRENDA team
Geobacillus stearothermophilus-652915--Manually annotated by BRENDA team
Homo sapiens-3213, 3217, 3218, 3220, 3223, 3233, 3245, 3251, 3254, 3255, 3261, 3262, 706661--Manually annotated by BRENDA team
Homo sapiens-681851, 705672P18669UniProtManually annotated by BRENDA team
Homo sapiensB-type phosphoglycerate mutase660903--Manually annotated by BRENDA team
Homo sapiensBB isoenzyme deficiency in a patient with non-spherocytic anemia661847--Manually annotated by BRENDA team
Homo sapienspatient with hereditary sperocytosis and 50% deficiency of enzyme activity in red blood cells661261--Manually annotated by BRENDA team
Hyphomicrobium sp.X3253--Manually annotated by BRENDA team
Hyphomicrobium sp. XX3253--Manually annotated by BRENDA team
Lactococcus lactis subsp. lactis-715964--Manually annotated by BRENDA team
Leishmania mexicana-649202, 705169Q86N96UniprotManually annotated by BRENDA team
Leishmania mexicanasp. mexicana661634Q86N96UniprotManually annotated by BRENDA team
Lilium longiflorum-3222--Manually annotated by BRENDA team
Methanocaldococcus jannaschii-651372--Manually annotated by BRENDA team
Mus musculus-677393, 703862--Manually annotated by BRENDA team
Mus musculus-690732Q9DBJ1UniProtManually annotated by BRENDA team
Mycobacterium tuberculosis-660610, 660633--Manually annotated by BRENDA team
Neurospora crassa-3237, 3238--Manually annotated by BRENDA team
Nicotiana tabacum-3228--Manually annotated by BRENDA team
Oryctolagus cuniculus-3213, 3214, 3239, 3240, 3242, 3247, 3256, 661851, 703707--Manually annotated by BRENDA team
Oryctolagus cuniculusOrycytolagus cuniculus3220--Manually annotated by BRENDA team
Oryza sativarice3259--Manually annotated by BRENDA team
Planococcus citreus-650753--Manually annotated by BRENDA team
Prunus dulcisalmond3223--Manually annotated by BRENDA team
Pseudomonas sp.AM13253--Manually annotated by BRENDA team
Pseudomonas sp. AM1AM13253--Manually annotated by BRENDA team
Pseudomonas syringae-3225--Manually annotated by BRENDA team
Pyrococcus furiosus-651372--Manually annotated by BRENDA team
Pyrococcus horikoshiistrain OT3677357--Manually annotated by BRENDA team
Rattus norvegicus-3227, 3232, 3236, 694050, 703707, 705270--Manually annotated by BRENDA team
Rattus norvegicusRattus norvegicus3220--Manually annotated by BRENDA team
Ricinus communis-3228, 3243--Manually annotated by BRENDA team
Saccharomyces cerevisiae-3213, 3214, 3215, 3230, 3231, 3239, 3240, 3257, 3258, 649656, 680944--Manually annotated by BRENDA team
Saccharomyces cerevisiae-3216, 649101, 652790, 652799P00950UniprotManually annotated by BRENDA team
Schizosaccharomyces pombe-3219, 3221, 3239, 649656, 651088, 652799--Manually annotated by BRENDA team
Schizosaccharomyces pombe-652846P36623UniprotManually annotated by BRENDA team
Solanum tuberosumpotato3239--Manually annotated by BRENDA team
Sporosarcina ureae-650753--Manually annotated by BRENDA team
Staphylococcus saprophyticus-650753--Manually annotated by BRENDA team
Streptomyces coelicolor-3229, 650753--Manually annotated by BRENDA team
Sulfolobus solfataricus-651716Q980A0UniprotManually annotated by BRENDA team
Sus scrofafragment693442B5KJG2, B5KJG3UniProtManually annotated by BRENDA team
Sus scrofapig3213, 3214, 3246, 3248, 3258--Manually annotated by BRENDA team
Thermoplasma acidophilumcofactor-dependent isoform679715Q9HL27UniprotManually annotated by BRENDA team
Triticum aestivumwheat3213, 3214, 3215, 3238, 3244, 3252, 3259--Manually annotated by BRENDA team
Trypanosoma brucei-651058Q9NG18SwissProtManually annotated by BRENDA team
Trypanosoma bruceicofactor-independent isoform682237--Manually annotated by BRENDA team
Ustilago maydis-692403--Manually annotated by BRENDA team
Vigna radiatamung bean3239--Manually annotated by BRENDA team
Wolbachia sp.-694538Q5GSN3UniProtManually annotated by BRENDA team
Wolbachia sp.-716984F4ZE02UniProtManually annotated by BRENDA team
Zea mays-3223, 3226, 3234--Manually annotated by BRENDA team
Zymomonas mobilis-3241--Manually annotated by BRENDA team
Micrococcus luteus-650753--Manually annotated by BRENDA team
additional informationby sequence alignment found in Arabidopsia thaliana, Oryza sativa, Anthithamnion sp., Escherichia coli, Bacillus subtilis, Bacillus megaterium, Caenorhabditis elegans3223--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
malfunctionHomo sapiens-knockdown of PGAM1 expression induces cancer cell apoptosis705672
metabolismLactococcus lactis subsp. lactis-despite the low level of PGM present in the cell, the enzyme is not rate limiting for glycolysis in Lactococcus lactis, probably due to a high catalytic processivity715964

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Brugia malayiQ4VWF8-662259--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Bacillus subtilis--650753-650753r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Mus musculus--703862--?
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Homo sapiens--661261, 706661--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Rattus norvegicus--705270--?
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Rattus norvegicus--694050, 703707--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Saccharomyces cerevisiaeP00950-3216-3216r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Saccharomyces cerevisiae--649101-649101r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Saccharomyces cerevisiae--652790-652790r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Saccharomyces cerevisiae--652799-652799r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Oryctolagus cuniculus--703707--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Geobacillus stearothermophilusQ9X519-650970-650970r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Geobacillus stearothermophilus--652915-652915r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Pyrococcus furiosus--651372-651372r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Entamoeba histolytica--661689--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Thermoplasma acidophilumQ9HL27-679715--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Schizosaccharomyces pombe--649656-649656r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Schizosaccharomyces pombe--651088-651088r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Schizosaccharomyces pombe--652799-652799r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Schizosaccharomyces pombeP36623-652846-652846r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Caenorhabditis elegansG5EFZ1-662259--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Micrococcus luteus, Streptomyces coelicolor--650753-650753r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Leishmania mexicanaQ86N96-649202-649202r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Leishmania mexicanaQ86N96-661634--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Leishmania mexicana--705169--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Sulfolobus solfataricusQ980A0-651716-651716r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Ustilago maydis--692403--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Clostridium perfringens--650753-650753r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Methanocaldococcus jannaschii--651372-651372r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Archaeoglobus fulgidus--679715--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Staphylococcus saprophyticus, Sporosarcina ureae, Planococcus citreus--650753-650753r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Trypanosoma bruceiQ9NG18-651058-651058r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Geobacillus stearothermophilus--653052-653052r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Bacillus anthracisQ81X77-678734--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Sus scrofaB5KJG2, B5KJG3-693442--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Wolbachia sp.Q5GSN3-694538--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Mus musculusQ9DBJ1-690732--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Homo sapiens--705672--?
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Wolbachia sp.F4ZE02-716984--r
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Dirofilaria immitisF4ZE01-716984--r
2-phospho-D-glycerate + 2,3-bisphosphoglycerate3-phospho-D-glycerate + 2,3-bisphosphoglycerate
show the reaction diagram		Saccharomyces cerevisiae-phosphorylated PGAM also has low levels, i.e. 0.002% of mutase activity, of phosphatase activity649656-649656r
2-Phosphoglycerate3-Phosphoglycerate
show the reaction diagram		Bacillus subtilis--3250---
2-Phosphoglycerate3-Phosphoglycerate
show the reaction diagram		Escherichia coli--652877-652877r
2-Phosphoglycerate3-Phosphoglycerate
show the reaction diagram		Saccharomyces cerevisiae--3231---
2-Phosphoglycerate3-Phosphoglycerate
show the reaction diagram		Oryctolagus cuniculus--3242, 3247---
2-Phosphoglycerate3-Phosphoglycerate
show the reaction diagram		Pseudomonas syringae--3225---
3-phospho-D-glycerate2-phospho-D-glycerate
show the reaction diagram		Brugia malayiQ4VWF8-662259--r
3-phospho-D-glycerate2-phospho-D-glycerate
show the reaction diagram		Homo sapiens--661261--r
3-phospho-D-glycerate2-phospho-D-glycerate
show the reaction diagram		Entamoeba histolytica--661689--r
3-phospho-D-glycerate2-phospho-D-glycerate
show the reaction diagram		Lactococcus lactis subsp. lactis--715964--?
3-phospho-D-glycerate2-phospho-D-glycerate
show the reaction diagram		Thermoplasma acidophilumQ9HL27-679715--r
3-phospho-D-glycerate2-phospho-D-glycerate
show the reaction diagram		Caenorhabditis elegansG5EFZ1-662259--r
3-phospho-D-glycerate2-phospho-D-glycerate
show the reaction diagram		Leishmania mexicanaQ86N96-661634--r
3-phospho-D-glycerate2-phospho-D-glycerate
show the reaction diagram		Archaeoglobus fulgidus--679715--r
3-phospho-D-glycerate2-phospho-D-glycerate
show the reaction diagram		Bacillus anthracisQ81X77-678734--r
3-phospho-D-glycerate2-phospho-D-glycerate
show the reaction diagram		Wolbachia sp.F4ZE02-716984--r
3-phospho-D-glycerate2-phospho-D-glycerate
show the reaction diagram		Dirofilaria immitisF4ZE01-716984--r
3-Phosphoglycerate2-Phosphoglycerate
show the reaction diagram		Bacillus subtilis--3250---
3-Phosphoglycerate2-Phosphoglycerate
show the reaction diagram		Homo sapiens--3217-3217-
3-Phosphoglycerate2-Phosphoglycerate
show the reaction diagram		Rattus norvegicus--3236---
3-Phosphoglycerate2-Phosphoglycerate
show the reaction diagram		Sus scrofa--3246, 3248---
3-Phosphoglycerate2-Phosphoglycerate
show the reaction diagram		Saccharomyces cerevisiae--3215, 3231---
3-Phosphoglycerate2-Phosphoglycerate
show the reaction diagram		Schizosaccharomyces pombe--3219, 3221, 649656, 651088, 652799---
3-Phosphoglycerate2-Phosphoglycerate
show the reaction diagram		Streptomyces coelicolor--3229---
3-Phosphoglycerate2-Phosphoglycerate
show the reaction diagram		Zymomonas mobilis--3241---
3-Phosphoglycerate2-Phosphoglycerate
show the reaction diagram		Oryza sativa--3259---
3-Phosphoglycerate2-Phosphoglycerate
show the reaction diagram		Triticum aestivum-r3259---
3-Phosphoglycerate2-Phosphoglycerate
show the reaction diagram		Zea mays-r3234-3234-
3-Phosphoglycerate?
show the reaction diagram		Homo sapiens-glycolysis/gluconeogenesis3217---
3-Phosphoglycerate?
show the reaction diagram		Saccharomyces cerevisiae-glycolysis/gluconeogenesis3231---
Hydroxypyruvic acid 3-phosphate?
show the reaction diagram		Pseudomonas sp., Hyphomicrobium sp.-3-7% activity3253---
additional information?-Pseudomonas sp., Hyphomicrobium sp.-no substrates are beta-glycerol phosphate, DL-O-phosphoserine, DL-glyceric acid, 3-DL-chloroacetic acid, DL-Ser, DL-glyceraldehyde 3-phosphate3253---
additional information?-Homo sapiens-enzyme possesses some 2,3-bisphosphoglycerate phosphatase activity661261---

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Bacillus subtilis--650753-650753
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Mus musculus--703862--
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Rattus norvegicus--705270--
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Saccharomyces cerevisiaeP00950-3216-3216
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Saccharomyces cerevisiae--649101-649101
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Saccharomyces cerevisiae--652790-652790
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Saccharomyces cerevisiae--652799-652799
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Geobacillus stearothermophilusQ9X519-650970-650970
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Geobacillus stearothermophilus--652915-652915
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Pyrococcus furiosus--651372-651372
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Schizosaccharomyces pombe--649656-649656
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Schizosaccharomyces pombe--651088-651088
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Schizosaccharomyces pombe--652799-652799
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Schizosaccharomyces pombeP36623-652846-652846
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Micrococcus luteus, Streptomyces coelicolor--650753-650753
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Leishmania mexicanaQ86N96-649202-649202
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Sulfolobus solfataricusQ980A0-651716-651716
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Clostridium perfringens--650753-650753
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Methanocaldococcus jannaschii--651372-651372
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Staphylococcus saprophyticus, Sporosarcina ureae, Planococcus citreus--650753-650753
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Trypanosoma bruceiQ9NG18-651058-651058
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Geobacillus stearothermophilus--653052-653052
2-phospho-D-glycerate3-phospho-D-glycerate
show the reaction diagram		Homo sapiens--705672--
2-phospho-D-glycerate + 2,3-bisphosphoglycerate3-phospho-D-glycerate + 2,3-bisphosphoglycerate
show the reaction diagram		Saccharomyces cerevisiae--649656-649656
2-Phosphoglycerate3-Phosphoglycerate
show the reaction diagram		Escherichia coli--652877-652877
3-Phosphoglycerate?
show the reaction diagram		Homo sapiens-glycolysis/gluconeogenesis3217--
3-Phosphoglycerate?
show the reaction diagram		Saccharomyces cerevisiae-glycolysis/gluconeogenesis3231--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
2,3-bisphosphoglycerateSchizosaccharomyces pombe-required to prime the reaction in an initial phosphorylation step649656 2D-image
2,3-bisphosphoglyceric acidLactococcus lactis subsp. lactis-dependent on 2,3-bisphosphoglyceric acid for activity715964-
additional informationLeishmania mexicana-2,3-bisphosphoglycerate-independent iPGAM649202-
additional informationBacillus subtilis, Clostridium perfringens, Micrococcus luteus, Planococcus citreus, Sporosarcina ureae, Staphylococcus saprophyticus, Streptomyces coelicolor-2,3-bisphosphoglycerate independent phosphoglycerate mutase650753-
additional informationGeobacillus stearothermophilus-2,3-bisphosphoglycerare independend PGM650970-
additional informationTrypanosoma bruceiQ9NG182,3-bisphosphoglycerate indepencent iPGAM651058-
additional informationMethanocaldococcus jannaschii, Pyrococcus furiosus-2,3-bisphosphoglycerate independent phosphoglycerate mutase651372-
additional informationGeobacillus stearothermophilus-2,3-bisphosphoglycerate independent phosphoglycerate mutase652915-
additional informationGeobacillus stearothermophilus-2,3-bisphosphoglycerate phosphoglycerate mutase653052-
additional informationLeishmania mexicanaQ86N962,3-bisphosphoglycerate independent phosphoglycerate mutase661634-
additional informationEntamoeba histolytica-2,3-bisphosphoglycerate-independent phosphoglycerate mutase661689-
additional informationBrugia malayiQ4VWF82,3-bisphosphoglycerate-independent phosphoglycerate mutase662259-
additional informationCaenorhabditis elegansG5EFZ12,3-bisphosphoglycerate independent phosphoglycerate mutase662259-
additional informationUstilago maydis-PGAM activity is 2,3-bisphosphoglycerate cofactor independent692403-
additional informationWolbachia sp.Q5GSN3cofactor-independent694538-
additional informationLeishmania mexicana-phosphoglycerate mutase is cofactor-independent705169-
additional informationDirofilaria immitisF4ZE012,3-bisphosphoglycerate is not required as a cofactor716984-
additional informationWolbachia sp.F4ZE022,3-bisphosphoglycerate is not required as a cofactor716984-

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
Ca2+Staphylococcus saprophyticus-1 mm, 19% of activity with 0.5 mM Mn2+650753
Cd2+Sulfolobus solfataricusQ980A0divalent cation required for activity651716
Co2+Clostridium perfringens-required for activity, 2fold higher activity at 0.4 mM than with 0.5 mM Mn2+650753
Co2+Sulfolobus solfataricusQ980A0divalent cation required for activity, 3times higher activity than with Mn2+651716
Co2+Leishmania mexicana-two Co2+ are coordinated within the active site705169
CoCl2Leishmania mexicanaQ86N96inhibition by EDTA is reversible by incubation with CoCl2, but not MnCl2, FeSO4, CuSo4, NiCl2, ZnCl2661634
Mg2+Methanocaldococcus jannaschii, Pyrococcus furiosus-10 mM, slight activation651372
Mg2+Archaeoglobus fulgidus-Mn2+ and Mg2+ are required for thermal stability679715
Mn2+Bacillus megaterium-activation, best achieved in buffer of tetramethylenediamine tetraacetate or trimethylenediamine tetraacetate3224
Mn2+Bacillus subtilis, Clostridium perfringens, Planococcus citreus, Sporosarcina ureae, Staphylococcus saprophyticus-required for activity650753
Mn2+Geobacillus stearothermophilus-absolutely required for activity, maximal activation at 1 mM650970
Mn2+Sulfolobus solfataricusQ980A0divalent cation required for activity651716
Mn2+Geobacillus stearothermophilus-required for activity653052
Mn2+Bacillus megaterium-specific activator, none of the metal ions tested reaches more than 4% of the activity of EDTA-treated enzyme reactivated with Mn2+. Activation by Mn2+ is strongly pH-dependent within the physiological range677798
Mn2+Archaeoglobus fulgidus-in presence of 5 mM Mg2+, 2-3fold stimulation by 0.05 mM Mn2+. Mn2+ and Mg2+ are required for thermal stability679715
additional informationNicotiana tabacum, Ricinus communis-no metal ion requirement3228
additional informationRicinus communis-no requirement for divalent metal ions3243
additional informationMicrococcus luteus, Streptomyces coelicolor-no metal ions required for activity650753
additional informationBacillus megaterium-Cd2+, Zn2+, Fe2+, Ni2+, Cu2+, Mg2+, Ca2+, Sr2+, or Ba2+ give no more than 4% of the activity of EDTA-treated enzyme reactivated with Mn2+677798

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
1,10-phenanthrolineTriticum aestivum--3244 2D-image
1-benzyl 4-[(3R,4R,6R)-6-[1-(hex-5-ynoyloxy)-1-methylethyl]-1-oxaspiro[2.5]oct-4-yl] (2R)-2-(2,3-dihydro-1H-indol-3-ylmethyl)butanedioateHomo sapiens-i.e. MJE3, spiroepoxide with anti-proliferative effects in human breast cancer cells. MJE3 covalently inactiviates enzyme at K100681851 2D-image
2,3-ButanedioneOryctolagus cuniculus, Saccharomyces cerevisiae--3240 2D-image
2,3-ButanedioneBacillus subtilis--3250 2D-image
8-hydroxyquinoline 5-sulfonic acidTriticum aestivum--3238, 3244 2D-image
8-hydroxyquinoline 5-sulfonic acidEmericella nidulans--3238 2D-image
8-hydroxyquinoline 5-sulfonic acidBacillus subtilis--3239 2D-image
8-hydroxyquinoline 5-sulfonic acidCyberlindnera jadinii, Enterobacter aerogenes, Escherichia coli, Oryctolagus cuniculus, Saccharomyces cerevisiae, Schizosaccharomyces pombe-not inhibitory3239 2D-image
8-hydroxyquinoline 5-sulfonic acidSolanum tuberosum, Vigna radiata--3239 2D-image
benzene hexacarboxylateSaccharomyces cerevisiae, Schizosaccharomyces pombe--652799 2D-image
benzene-1,2,3-tricarboxylateSaccharomyces cerevisiae, Schizosaccharomyces pombe--652799 2D-image
benzene-1,2,4,5-tetracarboxylateSaccharomyces cerevisiae, Schizosaccharomyces pombe--652799 2D-image
benzene-1,2,4-tricarboxylateSaccharomyces cerevisiae, Schizosaccharomyces pombe--652799 2D-image
benzene-1,3,5-tricarboxylateSaccharomyces cerevisiae, Schizosaccharomyces pombe--652799 2D-image
Cd2+Bacillus subtilis--3250 2D-image
Cu2+Bacillus subtilis--3250 2D-image
diethyl dicarbonateLeishmania mexicanaQ86N96irreversible inhibition, saturating concentrations of substrate protect661634 2D-image
DiethyldicarbonateSchizosaccharomyces pombe--3219 2D-image
DiethyldicarbonateOryctolagus cuniculus, Saccharomyces cerevisiae--3240 2D-image
EDTATriticum aestivum--3238, 3244 2D-image
EDTAEmericella nidulans--3238 2D-image
EDTABacillus subtilis--3239, 3249, 3250 2D-image
EDTABacillus megaterium--3239, 3249 2D-image
EDTACyberlindnera jadinii, Enterobacter aerogenes, Escherichia coli, Oryctolagus cuniculus, Saccharomyces cerevisiae, Schizosaccharomyces pombe-not inhibitory3239 2D-image
EDTASolanum tuberosum, Vigna radiata--3239 2D-image
EDTAMethanocaldococcus jannaschii, Pyrococcus furiosus-2 mM, 20% inhibition651372 2D-image
EDTALeishmania mexicanaQ86N961 mM, 10% residual activty at pH 8.0, reversible by incubation with CoCl2, but not MnCl2, FeSO4, CuSo4, NiCl2, ZnCl2661634 2D-image
EDTABacillus megaterium-complete inactivation, reactivation by Mn2+677798 2D-image
EGTATriticum aestivum--3244 2D-image
Hg2+Bacillus subtilis--3250 2D-image
Inositol hexakisphosphateSaccharomyces cerevisiae, Schizosaccharomyces pombe--652799 2D-image
iodoacetateBacillus megaterium--3249 2D-image
N-BromoacetylethanolamineOryctolagus cuniculus--3256 2D-image
N-ethylmaleimideBacillus megaterium--3249 2D-image
Ni2+Bacillus subtilis--3250 2D-image
p-mercuribenzoateTriticum aestivum--3244 2D-image
Pb2+Bacillus subtilis--3250 2D-image
phosphateLeishmania mexicanaQ86N96100 mM, 70% residual activity661634 2D-image
Sodium metavanadateStreptomyces coelicolor--3229 2D-image
Sodium metavanadateZea mays-not inhibitory3234 2D-image
Sodium metavanadateStreptomyces coelicolor-0.01 mM and 0.1 mM, 50% and 90% inhibition of phosphoglycerate mutase activity, respectively650753 2D-image
tetrathionateSus scrofa-inactivation of MM-type isozyme, 50% of MB-type, BB-type not affected3248 2D-image
TrinitrobenzenesulfonateHomo sapiens--3251 2D-image
TrinitrobenzenesulfonateSaccharomyces cerevisiae--3257 2D-image
vanadateThermoplasma acidophilumQ9HL27up to 0.1 mM, 90% maximal inhibition. Inhibition may be partially reversed by EDTA679715 2D-image
Zn2+Bacillus subtilis--3250 2D-image
Zn2+Methanocaldococcus jannaschii-10 mM, 81% inhibition651372 2D-image
Zn2+Pyrococcus furiosus-10 mM, 85% inhibition651372 2D-image
metavanadateLactococcus lactis subsp. lactis-less than 5% residual activity at 10 mM after 10 min incubation715964-
additional informationSaccharomyces cerevisiae-not Mg2+3215-
additional informationTriticum aestivum--3215-
additional informationZea mays-not tetrathionate3234-
additional informationBacillus subtilis--3239-
additional informationCyberlindnera jadinii, Enterobacter aerogenes, Escherichia coli, Oryctolagus cuniculus, Saccharomyces cerevisiae, Schizosaccharomyces pombe-not EDTA3239-
additional informationRicinus communis-no influence on activity: fructose 6-phosphate, fructose 1,6-bisphosphate, glucose 6-phosphate, citric acid, malate, glyoxylate, phosphoenolpyruvate, pyruvate, phosphoglycolate, glyceric acid, alpha-glycerophosphate, iodoacetamide, Gly, Ser, diphosphate, 2,3-diglycerophosphate3243-
additional informationBacillus subtilis-no influence on activity: DL-sulfolactate, L-sulfolactate, dihydroxyacetone phosphate, DL-glycerate, DL-alpha-glycerophosphate, 3-hydroxypropionate, L-lactate, 3-mercaptopropionate, 2-mercaptopropionate, phosphoenolpyruvate, O-phosphoserine, DL-o-phosphothreonine, propionate, Li+, Ca2+, Co2+, Mg2+, Fe3+, Cr3+3250-
additional informationLeishmania mexicanaQ86N96not inhibitory: vanadate, cloride, sulfate661634-
additional informationBrugia malayiQ4VWF8not inhibitory: vanadate662259-
additional informationCaenorhabditis elegansG5EFZ1not inhibitory: vanadate662259-

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
2,3-bisphosphoglycerateSaccharomyces cerevisiae--3216, 649101, 649656, 652790, 652799 2D-image
2,3-bisphosphoglycerateSchizosaccharomyces pombe--651088, 652799 2D-image
2,3-bisphosphoglycerateEscherichia coli--652877 2D-image
2,3-bisphosphoglycerateArchaeoglobus fulgidus-strictly required, Km value 0.017 mM679715 2D-image
2,3-bisphosphoglycerateThermoplasma acidophilumQ9HL27strictly required, Km value 0.017 mM679715 2D-image
2,3-diphosphoglycerateHomo sapiens--3213, 3217 2D-image
2,3-diphosphoglycerateOryctolagus cuniculus, Saccharomyces cerevisiae--3213, 3239, 3240 2D-image
2,3-diphosphoglycerateTriticum aestivum-plant enzyme does not require a cofactor3213 2D-image
2,3-diphosphoglycerateSchizosaccharomyces pombe--3219, 3221, 3239 2D-image
2,3-diphosphoglycerateLilium longiflorum-no cofactor3222 2D-image
2,3-diphosphoglycerateZea mays-no cofactor3226 2D-image
2,3-diphosphoglycerateStreptomyces coelicolor--3229 2D-image
2,3-diphosphoglycerateSaccharomyces cerevisiae-Km: 0.0081, wild-type enzyme, Km: 0.087, H181A-mutant3230 2D-image
2,3-diphosphoglycerateSaccharomyces cerevisiae-Km: 0.005, wild-type enzyme, Km: 0.003, mutant K246G, Km: 0.048, mutant S11G3231 2D-image
2,3-diphosphoglycerateNeurospora crassa-no cofactor3237 2D-image
2,3-diphosphoglycerateEscherichia coli--3239, 3260 2D-image
2,3-diphosphoglycerateZymomonas mobilis--3241 2D-image
2,3-diphosphoglycerateBacillus subtilis-no cofactor3249, 3250 2D-image
2,3-diphosphoglycerateBacillus megaterium-no cofactor3249 2D-image
2,3-diphosphoglycerateTriticum aestivum-no cofactor3252, 3259 2D-image
2,3-diphosphoglycerateHyphomicrobium sp.-Km: 0.008 mM3253 2D-image
2,3-diphosphoglyceratePseudomonas sp.-Km: 0.01 mM3253 2D-image
2,3-diphosphoglycerateHomo sapiens-Km: 0.082 mM3254 2D-image
2,3-diphosphoglycerateOryza sativa-no cofactor3259 2D-image
2-phosphoglycollateSaccharomyces cerevisiae-18-20fold activation of phosphatase activity649656 2D-image
2-phosphoglycollateSchizosaccharomyces pombe-2.3fold activation of phosphatase activity649656 2D-image
2-phosphoglycollateSchizosaccharomyces pombe-slight activation of phosphatase activity651088 2D-image
2-phosphohydroxypyruvateSaccharomyces cerevisiae-30fold activation of phosphatase activity649656 2D-image
Co2+Mus musculusQ9DBJ1phosphoglycerate mutase is upregulated in the cobalt-treated mouse cerebrum690732 2D-image
additional informationRicinus communis-no influence on activity: fructose 6-phosphate, fructose 1,6-bisphosphate, glucose 6-phosphate, citric acid, malate, glyoxylate, phosphoenolpyruvate, pyruvate, phosphoglycolate, glyceric acid, alpha-glycerophosphate, iodoacetamide, Gly, Ser, diphosphate, 2,3-diglycerophosphate3243-
additional informationBacillus subtilis-no influence on activity: DL-sulfolactate, L-sulfolactate, dihydroxyacetone phosphate, DL-glycerate, DL-alpha-glycerophosphate, 3-hydroxypropionate, L-lactate, 3-mercaptopropionate, 2-mercaptopropionate, phosphoenolpyruvate, O-phosphoserine, DL-o-phosphothreonine, propionate3250-
additional informationMus musculusQ9DBJ1phosphoglycerate mutase activity increases by peony root extract administration690732-

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.066-2-phospho-D-glycerateEntamoeba histolytica-pH 7.0, 37°C661689 2D-image
0.106-2-phospho-D-glycerateEntamoeba histolytica-pH 6.0, 37°C661689 2D-image
0.11-2-phospho-D-glycerateLeishmania mexicanaQ86N96pH 7.6, 25°C661634 2D-image
0.16-2-phospho-D-glycerateTrypanosoma bruceiQ9NG18-651058 2D-image
0.2-2-phospho-D-glycerateArchaeoglobus fulgidus-pH 7.0, 50°C679715 2D-image
1.1-2-phospho-D-glycerateThermoplasma acidophilumQ9HL27pH 7.0, 50°C679715 2D-image
0.041-2-phosphoglycerateSaccharomyces cerevisiae-wild-type enzyme3231 2D-image
0.06-2-phosphoglycerateSaccharomyces cerevisiae-mutant K246G3231 2D-image
0.06-2-phosphoglycerateRicinus communis-2-phosphoglycerate, cytosolic enzyme3243 2D-image
0.067-2-phosphoglycerateSaccharomyces cerevisiae-mutant S11G3231 2D-image
0.112-2-phosphoglycerateRicinus communis-plastidic enzyme3243 2D-image
0.369-2-phosphoglycerateZea mays--3234 2D-image
0.37-2-phosphoglyceratePseudomonas sp.--3253 2D-image
0.69-2-phosphoglycerateHyphomicrobium sp.--3253 2D-image
1.47-2-phosphoglycerateBacillus subtilis--3250 2D-image
4.4-2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(1-benzyl-2-oxo-2-thiazol-2-yl-ethyl)-acetamideGeobacillus stearothermophilus-pH 7.4, 1 mM Mn2+653052 2D-image
0.15-3-phospho-D-glycerateTrypanosoma bruceiQ9NG18-651058 2D-image
0.22-3-phospho-D-glycerateSaccharomyces cerevisiae-phosphatase activity649656 2D-image
0.27-3-phospho-D-glycerateLeishmania mexicanaQ86N96pH 7.6, 25°C661634 2D-image
0.4-3-phospho-D-glycerateSaccharomyces cerevisiae-L245G mutant649656 2D-image
0.4-3-phospho-D-glycerateHomo sapiens-pH 7.4, 30°C661261 2D-image
0.43-3-phospho-D-glycerateSaccharomyces cerevisiae-A60S mutant652790 2D-image
0.47-3-phospho-D-glycerateSaccharomyces cerevisiae-mutase activity649656 2D-image
0.47-3-phospho-D-glycerateSaccharomyces cerevisiae--652790 2D-image
0.49-3-phospho-D-glyceratePyrococcus furiosus-50°C, pH 8.0651372 2D-image
0.5-3-phospho-D-glycerateEntamoeba histolytica-pH 7.0, 37°C661689 2D-image
0.55-3-phospho-D-glycerateWolbachia sp.F4ZE02in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C716984 2D-image
0.58-3-phospho-D-glycerateDirofilaria immitisF4ZE01in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C716984 2D-image
0.63-3-phospho-D-glycerateSaccharomyces cerevisiae-L246G mutant649656 2D-image
0.71-3-phospho-D-glycerateSaccharomyces cerevisiae-S11A mutant652790 2D-image
0.83-3-phospho-D-glycerateEntamoeba histolytica-pH 6.0, 37°C661689 2D-image
1.03-3-phospho-D-glycerateLactococcus lactis subsp. lactis-in triethanol-HCl buffer (125 mM, pH 7.2, 5 mM MgCl2, 10 mM KCl), 0.1 mM 2,3-bisphosphoglyceric acid, temperature not specified in the publication715964 2D-image
1.1-3-phospho-D-glycerateSaccharomyces cerevisiae-E86Q mutant652790 2D-image
1.43-3-phospho-D-glycerateSaccharomyces cerevisiae-L245G/L246G double mutant649656 2D-image
3.3-3-phospho-D-glycerateArchaeoglobus fulgidus-pH 7.0, 50°C679715 2D-image
3.3-3-phospho-D-glycerateThermoplasma acidophilumQ9HL27pH 7.0, 50°C679715 2D-image
3.6-3-phospho-D-glycerateBacillus subtilis-25°C, pH 6.0650753 2D-image
4.2-3-phospho-D-glycerateClostridium perfringens-25°C, pH 7.0650753 2D-image
4.4-3-phospho-D-glycerateBacillus subtilis-25°C, pH 7.0650753 2D-image
4.9-3-phospho-D-glycerateBacillus subtilis, Clostridium perfringens-25°C, pH 8.0650753 2D-image
5.2-3-phospho-D-glycerateClostridium perfringens-25°C, pH 6.0650753 2D-image
0.026-3-phosphoglycerateSaccharomyces cerevisiae-H181A mutant3230 2D-image
0.1-3-phosphoglycerateSus scrofa-MB-type and BB-type isozymes3248 2D-image
0.2-3-phosphoglycerateSus scrofa-MM-type isozyme3248 2D-image
0.22-3-phosphoglycerateHomo sapiens--3251 2D-image
0.324-3-phosphoglycerateZea mays--3234 2D-image
0.33-3-phosphoglycerateRicinus communis-cytosolic enzyme3243 2D-image
0.33-3-phosphoglycerateMethanocaldococcus jannaschii-50°C, pH 8.0651372 2D-image
0.43-3-phosphoglycerateRicinus communis-plastidic enzyme3243 2D-image
0.56-3-phosphoglycerateSaccharomyces cerevisiae--652799 2D-image
0.58-3-phosphoglycerateSchizosaccharomyces pombe-mutase activity649656 2D-image
0.58-3-phosphoglycerateSchizosaccharomyces pombe--651088, 652799 2D-image
0.65-3-phosphoglycerateSaccharomyces cerevisiae-wild-type enzyme3231 2D-image
0.67-3-phosphoglycerateSaccharomyces cerevisiae-mutant S11G3231 2D-image
0.68-3-phosphoglycerateSaccharomyces cerevisiae-mutant K246G3231 2D-image
0.74-3-phosphoglycerateSaccharomyces cerevisiae-wild-type enzyme3230 2D-image
1.1-3-phosphoglycerateZymomonas mobilis--3241 2D-image
1.1-3-phosphoglycerateBacillus subtilis--3250 2D-image
1.25-3-phosphoglycerateSchizosaccharomyces pombe-E93D mutant651088 2D-image
1.3-3-phosphoglycerateStreptomyces coelicolor--3229 2D-image
1.54-3-phosphoglycerateSchizosaccharomyces pombe-R14Q mutant651088 2D-image
2.64-3-phosphoglycerateSchizosaccharomyces pombe-R120Q mutant651088 2D-image
3.4-3-phosphoglyceratePseudomonas sp.--3253 2D-image
4.9-3-phosphoglycerateSchizosaccharomyces pombe-R121Q mutant651088 2D-image
5.26-3-phosphoglycerateSchizosaccharomyces pombe-R120Q/R121Q double mutant651088 2D-image
6-3-phosphoglycerateHyphomicrobium sp.--3253 2D-image
7.46-3-phosphoglycerateSchizosaccharomyces pombe-R94Q mutant651088 2D-image
additional information-additional informationBacillus megaterium--3249-
additional information-additional informationOryza sativa, Triticum aestivum--3259-

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
6.4-2-phospho-D-glycerateEntamoeba histolytica-pH 6.0, 37°C661689 2D-image
14-2-phospho-D-glycerateEntamoeba histolytica-pH 7.0, 37°C661689 2D-image
199-2-phospho-D-glycerateLeishmania mexicanaQ86N96pH 7.6, 25°C661634 2D-image
0.0009-3-phospho-D-glycerateSaccharomyces cerevisiae-phosphatase activity649656 2D-image
0.02-3-phospho-D-glycerateSchizosaccharomyces pombe-phosphatase activity649656 2D-image
4.7-3-phospho-D-glycerateSaccharomyces cerevisiae-E86Q mutant652790 2D-image
20-3-phospho-D-glycerateSaccharomyces cerevisiae-S11A mutant652790 2D-image
45-3-phospho-D-glycerateEntamoeba histolytica-pH 7.0, 37°C661689 2D-image
57-3-phospho-D-glycerateEntamoeba histolytica-pH 6.0, 37°C661689 2D-image
82-3-phospho-D-glycerateSchizosaccharomyces pombe-mutase activity649656 2D-image
82-3-phospho-D-glycerateSchizosaccharomyces pombe--652799 2D-image
102-3-phospho-D-glycerateWolbachia sp.F4ZE02in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C716984 2D-image
132-3-phospho-D-glycerateDirofilaria immitisF4ZE01in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C716984 2D-image
370-3-phospho-D-glycerateSaccharomyces cerevisiae-A60S mutant652790 2D-image
434-3-phospho-D-glycerateLeishmania mexicanaQ86N96pH 7.6, 25°C661634 2D-image
530-3-phospho-D-glycerateSaccharomyces cerevisiae-mutase activity649656 2D-image
530-3-phospho-D-glycerateSaccharomyces cerevisiae--652790 2D-image
3200-3-phospho-D-glycerateLactococcus lactis subsp. lactis-in triethanol-HCl buffer (125 mM, pH 7.2, 5 mM MgCl2, 10 mM KCl), 0.1 mM 2,3-bisphosphoglyceric acid, temperature not specified in the publication715964 2D-image
0.078-3-phosphoglycerateSaccharomyces cerevisiae-mutant H181A3230 2D-image
2.1-3-phosphoglycerateSaccharomyces cerevisiae-mutant S11G3231 2D-image
324-3-phosphoglycerateSaccharomyces cerevisiae-mutant K246G3231 2D-image
384-3-phosphoglycerateSaccharomyces cerevisiae-wild-type enzyme3231 2D-image
490-3-phosphoglycerateSaccharomyces cerevisiae-wild-type enzyme3230 2D-image
530-3-phosphoglycerateSaccharomyces cerevisiae--652799 2D-image
additional information-additional informationOryza sativa, Triticum aestivum--3259-

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
186-3-phospho-D-glycerateWolbachia sp.F4ZE02in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C7169844061
228-3-phospho-D-glycerateDirofilaria immitisF4ZE01in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C7169844061

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.006-benzene hexacarboxylateSaccharomyces cerevisiae--652799 2D-image
0.022-benzene hexacarboxylateSchizosaccharomyces pombe--652799 2D-image
0.023-benzene-1,2,3-tricarboxylateSaccharomyces cerevisiae--652799 2D-image
0.067-benzene-1,2,3-tricarboxylateSchizosaccharomyces pombe--652799 2D-image
0.013-benzene-1,2,4,5-tetracarboxylateSaccharomyces cerevisiae--652799 2D-image
0.055-benzene-1,2,4,5-tetracarboxylateSchizosaccharomyces pombe--652799 2D-image
0.021-benzene-1,2,4-tricarboxylateSaccharomyces cerevisiae--652799 2D-image
0.062-benzene-1,2,4-tricarboxylateSchizosaccharomyces pombe--652799 2D-image
0.024-benzene-1,3,5-tricarboxylateSaccharomyces cerevisiae--652799 2D-image
0.053-benzene-1,3,5-tricarboxylateSchizosaccharomyces pombe--652799 2D-image
0.004-Inositol hexakisphosphateSaccharomyces cerevisiae--652799 2D-image
0.035-Inositol hexakisphosphateSchizosaccharomyces pombe--652799 2D-image

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
0.003-Sporosarcina ureae--650753
0.014-Bacillus subtilis--650753
0.1-Staphylococcus saprophyticus--650753
0.24-Clostridium perfringens--650753
0.49-Micrococcus luteus--650753
0.5-Homo sapiens-glioblastoma3217
0.56-Homo sapiens-anaplastic astrocytoma3217
0.67-Homo sapiens-meningioma3217
0.7-Homo sapiens-astrocytoma3217
0.93-Streptomyces coelicolor--650753
1-Planococcus citreus--650753
1.5-Homo sapiens-brain, normal tissue3217
3.22-Hyphomicrobium sp.--3253
3.3-Archaeoglobus fulgidus-pH 7.0, 50°C679715
12-Thermoplasma acidophilumQ9HL27pH 7.0, 50°C679715
20.03-Pseudomonas sp.--3253
37-Bacillus anthracisQ81X7723°C678734
40-Caenorhabditis elegansG5EFZ1pH 7.0, 30°C, formation of 2-phospho-D-glycerate662259
71-Wolbachia sp.F4ZE02in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C716984
72-Caenorhabditis elegansG5EFZ1pH 7.0, 30°C, formation of 3-phospho-D-glycerate662259
83.8-Ricinus communis-plastidic enzyme3243
93-Brugia malayiQ4VWF8pH 7.0, 30°C, formation of 2-phospho-D-glycerate662259
100.4-Trypanosoma bruceiQ9NG18-651058
124-Escherichia coli--3260
202.5-Zea mays--3234
210-Schizosaccharomyces pombe-chromosomal enzyme3221
210-Sus scrofa--3246
218-Schizosaccharomyces pombe-recombinant enzyme3221
225-Dirofilaria immitisF4ZE01in 30 mM Tris-HCl, 5 mM MgSO4, 20 mM KCl, pH 7.5, at 30°C716984
256-Brugia malayiQ4VWF8pH 7.0, 30°C, formation of 3-phospho-D-glycerate662259
419-Leishmania mexicanaQ86N96formation of 2-phospho-D-glycerate, pH 7.6, 25°C661634
440-Oryctolagus cuniculus--3242
500-Geobacillus stearothermophilus-selenomethionyl-phosphoglycerate mutase653052
515-Homo sapiens--3254
621-Bacillus subtilis--3250
622.5-Ricinus communis-cytosolic enzyme3243
1027-Triticum aestivum--3259
1200-Ricinus communis--3228
1280-Saccharomyces cerevisiae--3257
1500-Geobacillus stearothermophilus-methionyl-phosphoglycerate mutase653052
2000-Zymomonas mobilis--3241
2880-Streptomyces coelicolor--3229
additional information-Saccharomyces cerevisiae, Triticum aestivum--3215
additional information-Homo sapiens--3218
additional information-Triticum aestivum--3244
additional information-Homo sapiens--3245
additional information-Gallus gallus, Saccharomyces cerevisiae, Sus scrofa--3258

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
5.86.2Entamoeba histolytica-formation of 2-phospho-D-glycerate661689
5.9-Saccharomyces cerevisiae--3215
6.8-Homo sapiens--3254
77.6Pseudomonas sp.--3253
7-Ricinus communis-cytosolic enzyme, substrate 3-phosphoglycerate or 2-phosphoglycerate3243
7-Sus scrofa--3248
7-Entamoeba histolytica-formation of 3-phospho-D-glycerate661689
7.1-Archaeoglobus fulgidus--679715
7.3-Ricinus communis-plastidic enzyme, substrate 2-phosphoglycerate3243
7.3-Hyphomicrobium sp.--3253
7.57.8Bacillus subtilis--3250
7.58.2Leishmania mexicanaQ86N96for both directions of reaction661634
7.5-Ricinus communis-plastidic enzyme, substrate 3-phoshoglycerate3243
7.78.3Bacillus megaterium--3249
7.8-Zea mays--3234
8-Bacillus subtilis, Clostridium perfringens, Micrococcus luteus, Planococcus citreus, Sporosarcina ureae, Staphylococcus saprophyticus, Streptomyces coelicolor--650753
8-Geobacillus stearothermophilus--650970
8-Methanocaldococcus jannaschii, Pyrococcus furiosus--651372
8-Geobacillus stearothermophilus-280fold and 25fold increase in activity if pH is raised from 6.0 to 8.0 in the presence of 0.004 mM Mn2+ and 1 mM Mn2+, respectively653052
9-Saccharomyces cerevisiae--3215

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
68Sus scrofa-less than 50% of maximal activity above and below3248
68Bacillus subtilis-24% and 36% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively650753
68Clostridium perfringens-7.3% and 39% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively, inhibition at low pH is reversed by elevating the pH650753
68Micrococcus luteus-little change in activity between pH 6.0 and pH 8.0650753
68Planococcus citreus-1.7% and 19% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively650753
68Sporosarcina ureae-1% and 18% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively650753
68Staphylococcus saprophyticus-3.1% and 21% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively650753
68Streptomyces coelicolor-little change in activity between pH 6.0 and pH 8.0650753
68Geobacillus stearothermophilus-2% and 22% of maximal activity at pH 6.0 and pH 7.0, respectively, at 1 mM Mn2+650970
68.1Bacillus subtilis--3250
68.7Zea mays-less than 50% of maximal activity above and below3234
6-Archaeoglobus fulgidus-about 40% of maximal activity679715
6.88.8Leishmania mexicanaQ86N96more than 75% of maximum activity within this range, formation of 2-phospho-D-glycerate661634
7.7-Archaeoglobus fulgidus-about 70% of maximal activity679715

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
5.26-Leishmania mexicanaQ86N96calculated661634
5.5-Trypanosoma bruceiQ9NG18predicted from amino acid sequence651058
6-Geobacillus stearothermophilus-isoelectric focusing653052
6.3-Dirofilaria immitisF4ZE01calculated from amino acid sequence716984
6.5-Rattus norvegicus-isoelectric focusing694050
6.6-Mus musculusQ9DBJ1isoelectric focusing690732
6.7-Homo sapiens-calculated from amino acid sequence705672
7.4-Wolbachia sp.F4ZE02calculated from amino acid sequence716984

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
antherLilium longiflorum--3222Manually annotated by BRENDA team
brainHomo sapiens-distribution in normal brain, astrocytomas, anaplastic astrocytomas, glioblastomas, meningiomas, no difference in subunit-type in normal and tumor brain cells; regional distribution3217Manually annotated by BRENDA team
brainHomo sapiens-in tumor cells the amount of EC 5.4.2.1 is decreased compared to normal cells3218Manually annotated by BRENDA team
brainHomo sapiens, Oryctolagus cuniculus, Rattus norvegicus-distribution of BB-type MB-type and MM-type iszozymes3220Manually annotated by BRENDA team
brainBos taurus--3235Manually annotated by BRENDA team
brainRattus norvegicus--3236, 705270Manually annotated by BRENDA team
brainHomo sapiens--3261Manually annotated by BRENDA team
cardiac muscleSus scrofaB5KJG2, B5KJG3; 693442Manually annotated by BRENDA team
cerebrumMus musculusQ9DBJ1-690732Manually annotated by BRENDA team
colonHomo sapiens-adenocarcinoma, in tumor cells EC 5.4.2.1 is found in increased amounts compared to normal cells, in contrast to this a decrease occurs in brain tumor cells3218Manually annotated by BRENDA team
colonHomo sapiens, Oryctolagus cuniculus, Rattus norvegicus-enzyme present in small amounts, distribution of BB-type MB-type and MM-type iszozymes3220Manually annotated by BRENDA team
endotheliumRattus norvegicus-capillary and artery endothelia of the brain, liver and kidney694050Manually annotated by BRENDA team
erythroblastOryctolagus cuniculus-increase in enzyme activity and mRNA level after application of triiodothyronine or induction of hypoxia by 90% nitrogen/10% oxygen. Propylthiouracil produces decrease in enzyme activity661851Manually annotated by BRENDA team
erythrocyteHomo sapiens, Oryctolagus cuniculus, Rattus norvegicus-enzyme present in small amounts, distribution of BB-type MB-type and MM-type iszozymes3220Manually annotated by BRENDA team
erythrocyteHomo sapiens--3245, 3251, 3254, 3255Manually annotated by BRENDA team
erythrocyteHomo sapiens-hemoglobin-free hemolysate661261Manually annotated by BRENDA team
germTriticum aestivum--3244, 3252, 3259Manually annotated by BRENDA team
germOryza sativa--3259Manually annotated by BRENDA team
heartRattus norvegicus-in early fetal life PGAM-BB is the only isozyme present in all tissues, in myogenesis these phenotypes undergo transition to MM-type via an MB-hybrid, all isozymes are present in mature heart tissue, enzyme activity increases with administration of 3,3'-triiodo-D-thyronine to the animal3227Manually annotated by BRENDA team
heartSus scrofa--3248Manually annotated by BRENDA team
heartMus musculus--703862Manually annotated by BRENDA team
Hep-G2 cellHomo sapiens--705672Manually annotated by BRENDA team
hepatocellular carcinoma cellHomo sapiens--705672Manually annotated by BRENDA team
kidneyHomo sapiens, Oryctolagus cuniculus, Rattus norvegicus-distribution of BB-type MB-type and MM-type iszozymes3220Manually annotated by BRENDA team
kidneySus scrofa--3258Manually annotated by BRENDA team
kidneySus scrofaB5KJG2, B5KJG3low level of transcripts is detected in kidney; low level of transcripts is detected in kidney693442Manually annotated by BRENDA team
leafLilium longiflorum--3222Manually annotated by BRENDA team
leafNicotiana tabacum--3228Manually annotated by BRENDA team
liverHomo sapiens-adenocarcinoma3218Manually annotated by BRENDA team
liverHomo sapiens, Oryctolagus cuniculus, Rattus norvegicus-distribution of BB-type MB-type and MM-type iszozymes3220Manually annotated by BRENDA team
liverSus scrofa--3246Manually annotated by BRENDA team
liverHomo sapiens--705672Manually annotated by BRENDA team
lungHomo sapiens-adenocarcinoma, squamous cell carcinoma, carcinoid, in tumor cells EC 5.4.2.1 is found in increased amounts compared to normal cells, in contrast to this a decrease occurs in brain tumor cells3218Manually annotated by BRENDA team
muscleHomo sapiens, Oryctolagus cuniculus, Rattus norvegicus-distribution of BB-type MB-type and MM-type isozymes3220Manually annotated by BRENDA team
muscleRattus norvegicus-in early fetal life PGAM-BB is the only isozyme present in all tissues, in myogenesis these phenotypes undergo transition to MM-type via a MB-hybrid, only MM-type isozyme is present in mature muscle tissue, enzyme activity increases with administration of 3,3'-triiodo-D-thyronine to the animals3227Manually annotated by BRENDA team
muscleRattus norvegicus--3232, 3236Manually annotated by BRENDA team
muscleHomo sapiens--3233, 3262Manually annotated by BRENDA team
muscleOryctolagus cuniculus--3240, 3242, 3247, 3256Manually annotated by BRENDA team
muscleSus scrofa--3246, 3258Manually annotated by BRENDA team
muscleGallus gallus--3258Manually annotated by BRENDA team
reticulocyteOryctolagus cuniculus-increase in enzyme activity and mRNA level after application of triiodothyronine or induction of hypoxia by 90% nitrogen/10% oxygen. Propylthiouracil produces decrease in enzyme activity661851Manually annotated by BRENDA team
rootLilium longiflorum--3222Manually annotated by BRENDA team
seedZea mays--3223, 3226, 3234Manually annotated by BRENDA team
seedPrunus dulcis--3223Manually annotated by BRENDA team
seedRicinus communis--3228, 3243Manually annotated by BRENDA team
serumHomo sapiens-the serum of healthy persons contains BB-type isozyme, whereas in patients with Duchenne muscular dystrophy it contains MM-type isozyme3233Manually annotated by BRENDA team
skeletal muscleSus scrofaB5KJG2, B5KJG3Pgam2 is expressed at a high level in skeletal muscle during all the development stages; Pgam2 is expressed at a high level in skeletal muscle during all the development stages693442Manually annotated by BRENDA team
skeletal muscleOryctolagus cuniculus, Rattus norvegicus-in mammalian skeletal muscles, PGM is organized in a regular, striated fashion within the sarcomere. In the absence of the enzyme effectors, PGM localizes mainly at the M-line, but under conditions typical for contracting muscle, the enzyme accumulates within the I-band of the sarcomere703707Manually annotated by BRENDA team
skeletal muscleMus musculus--703862Manually annotated by BRENDA team
small intestineHomo sapiens, Oryctolagus cuniculus, Rattus norvegicus-enzyme present in small amounts, distribution of BB-type MB-type and MM-type iszozymes3220Manually annotated by BRENDA team
styleLilium longiflorum--3222Manually annotated by BRENDA team
lungHomo sapiens, Oryctolagus cuniculus, Rattus norvegicus-enzyme present in small amounts, distribution of BB-type MB-type and MM-type iszozymes3220Manually annotated by BRENDA team
additional informationRattus norvegicus-in early fetal life PGAM-BB is the only isozyme present in all tissues, in myogenesis these phenotypes undergo transition to MM-type via a MB-hybrid3227Manually annotated by BRENDA team

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
cytoplasmRattus norvegicus--57373232Manually annotated by BRENDA team
cytoplasmSus scrofaB5KJG2, B5KJG3; 5737693442Manually annotated by BRENDA team
cytosolRicinus communis--58293228, 3243Manually annotated by BRENDA team
nucleusRattus norvegicus--56343232Manually annotated by BRENDA team
nucleusSus scrofaB5KJG2, B5KJG3; 5634693442Manually annotated by BRENDA team
particle-boundLilium longiflorum---3222Manually annotated by BRENDA team
plastidLilium longiflorum--95363222Manually annotated by BRENDA team
plastidRicinus communis--95363228, 3243Manually annotated by BRENDA team
solubleLilium longiflorum---3222Manually annotated by BRENDA team
solubleStreptomyces coelicolor---3229Manually annotated by BRENDA team
cytosolLeishmania mexicanaQ86N96-5829661634Manually annotated by BRENDA team
additional informationRattus norvegicus-not in mitochondria, lysosomes, or other cytoplasmic organelles-3232Manually annotated by BRENDA team

PDBSCOPCATHORGANISM
2ify, downloadSCOP (2ify)CATH (2ify)Bacillus anthracis
4emb, downloadSCOP (4emb)CATH (4emb)Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
3ezn, downloadSCOP (3ezn)CATH (3ezn)Burkholderia pseudomallei (strain 1710b)
3fdz, downloadSCOP (3fdz)CATH (3fdz)Burkholderia pseudomallei (strain 1710b)
3lnt, downloadSCOP (3lnt)CATH (3lnt)Burkholderia pseudomallei (strain 1710b)
3gp3, downloadSCOP (3gp3)CATH (3gp3)Burkholderia pseudomallei (strain K96243)
3gp5, downloadSCOP (3gp5)CATH (3gp5)Burkholderia pseudomallei (strain K96243)
3gw8, downloadSCOP (3gw8)CATH (3gw8)Burkholderia pseudomallei (strain K96243)
1e58, downloadSCOP (1e58)CATH (1e58)Escherichia coli (strain K12)
1e59, downloadSCOP (1e59)CATH (1e59)Escherichia coli (strain K12), Escherichia coli O157:H7, Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
1ejj, downloadSCOP (1ejj)CATH (1ejj)Geobacillus stearothermophilus
1eqj, downloadSCOP (1eqj)CATH (1eqj)Geobacillus stearothermophilus
1o98, downloadSCOP (1o98)CATH (1o98)Geobacillus stearothermophilus
1o99, downloadSCOP (1o99)CATH (1o99)Geobacillus stearothermophilus
1lno, downloadSCOP (1lno)CATH (1lno)Helicobacter pylori (strain ATCC 700392 / 26695)
1ljd, downloadSCOP (1ljd)CATH (1ljd)Homo sapiens
1yfk, downloadSCOP (1yfk)CATH (1yfk)Homo sapiens
1yjx, downloadSCOP (1yjx)CATH (1yjx)Homo sapiens
2f90, downloadSCOP (2f90)CATH (2f90)Homo sapiens
2h4x, downloadSCOP (2h4x)CATH (2h4x)Homo sapiens
2h4z, downloadSCOP (2h4z)CATH (2h4z)Homo sapiens
2h52, downloadSCOP (2h52)CATH (2h52)Homo sapiens
2hhj, downloadSCOP (2hhj)CATH (2hhj)Homo sapiens
3nfy, downloadSCOP (3nfy)CATH (3nfy)Homo sapiens
3igy, downloadSCOP (3igy)CATH (3igy)Leishmania mexicana
3igz, downloadSCOP (3igz)CATH (3igz)Leishmania mexicana
4eo9, downloadSCOP (4eo9)CATH (4eo9)Mycobacterium leprae (strain Br4923)
1rii, downloadSCOP (1rii)CATH (1rii)Mycobacterium tuberculosis
2a6p, downloadSCOP (2a6p)CATH (2a6p)Mycobacterium tuberculosis
3eoz, downloadSCOP (3eoz)CATH (3eoz)Plasmodium falciparum (isolate 3D7)
3kkk, downloadSCOP (3kkk)CATH (3kkk)Plasmodium falciparum (isolate 3D7)
2zkt, downloadSCOP (2zkt)CATH (2zkt)Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
1bq3, downloadSCOP (1bq3)CATH (1bq3)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
1bq4, downloadSCOP (1bq4)CATH (1bq4)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
1qhf, downloadSCOP (1qhf)CATH (1qhf)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
4pgm, downloadSCOP (4pgm)CATH (4pgm)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
5pgm, downloadSCOP (5pgm)CATH (5pgm)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
1fzt, downloadSCOP (1fzt)CATH (1fzt)Schizosaccharomyces pombe (strain 972 / ATCC 24843)
1e59, downloadSCOP (1e59)CATH (1e59)Shigella flexneri
3idd, downloadSCOP (3idd)CATH (3idd)Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
3kd8, downloadSCOP (3kd8)CATH (3kd8)Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
1v37, downloadSCOP (1v37)CATH (1v37)Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
1v7q, downloadSCOP (1v7q)CATH (1v7q)Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
2p9f, downloadSCOP (2p9f)CATH (2p9f)Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
3nvl, downloadSCOP (3nvl)CATH (3nvl)Trypanosoma brucei brucei (strain 927/4 GUTat10.1)

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
28680-Sus scrofaB5KJG2, B5KJG3calculated from amino acid sequence; calculated from amino acid sequence693442
28900-Homo sapiens-calculated from amino acid sequence705672
28940-Mus musculusQ9DBJ1deduced from amino acid sequence690732
29000-Rattus norvegicus-SDS-PAGE694050
30500-Mus musculusQ9DBJ1gel filtration690732
46000-Archaeoglobus fulgidus-gel filtration679715
46000-Thermoplasma acidophilumQ9HL27gel filtration679715
46700-Mycobacterium tuberculosis-dynamic light scattering660633
5000060000Neurospora crassa-gel filtration, SDS-PAGE3237
52000-Zymomonas mobilis-gel filtration3241
54000-Triticum aestivum-sedimentation equilibrium centrifugation3252
56000-Homo sapiens-gel filtration3254, 3255
56000-Wolbachia sp.Q5GSN3deduced from sequence of cDNA694538
56300-Escherichia coli-sedimentation equilibrium centrifugtion3260
57000-Sus scrofa-gel filtration3248
58000-Triticum aestivum-gel filtration3252
60000-Rattus norvegicus-MM-type isozyme in nucleus and cytoplasm, gel filtration3232
60000-Emericella nidulans-gel filtration, SDS-PAGE3238
61000-Bacillus megaterium-gel filtration, SDS-PAGE3249
63500-Ricinus communis-plastidic enzyme, gel filtration3243
64000-Zea mays-gel filtration, SDS-PAGE3234
64500-Ricinus communis-cytosolic enzyme, gel filtration3243
100000-Wolbachia sp.Q5GSN3around 100000 Da, SDS-PAGE, enzyme fused with N-terminal maltose binding protein694538
102000-Lactococcus lactis subsp. lactis-gel filtration715964
120000-Streptomyces coelicolor-gel filtration3229
183500-Pyrococcus furiosus-gel filtration651372
190600-Methanocaldococcus jannaschii-gel filtration651372

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
?Sulfolobus solfataricusQ980A0x * 45179, deduced from nucleotide sequence; x * 46000, SDS-PAGE651716
?Geobacillus stearothermophilus-x * 60000, SDS-PAGE653052
?Leishmania mexicanaQ86N96x * 60724, calculated, x * 60000, recombinant protein with His-tag, SDS-PAGE661634
?Brugia malayiQ4VWF8x * 60000, SDS-PAGE662259
?Caenorhabditis elegansG5EFZ1x * 60000, SDS-PAGE662259
?Dirofilaria immitisF4ZE01x * 57000, calculated from amino acid sequence716984
?Wolbachia sp.F4ZE02x * 56000, calculated from amino acid sequence716984
dimerRattus norvegicus-2 * 29000, SDS-PAGE, immunologically the MM-type and BB-type subunits show cross-reactivity as shown by ELISA and immunological neutralization, evidence for common antigenic determinants3236
dimerOryctolagus cuniculus--3240
dimerZymomonas mobilis-2 * 26000, SDS-PAGE3241
dimerSus scrofa-2 * 29000, SDS-PAGE3248
dimerHomo sapiens-2 * 28000-28600, SDS-PAGE3254, 3255
dimerEscherichia coli-crystal structure652877
dimerMycobacterium tuberculosis-2 * 21948, calculated660633
dimerPyrococcus horikoshii-dynamic light scattering and crystallization data677357
dimerThermoplasma acidophilumQ9HL272 * 23800, calculated, 2 * 24000, SDS-PAGE679715
homotetramerLactococcus lactis subsp. lactis-2 * 26000, calculated from amino acid sequence715964
monomerZea mays-1 * 64000, SDS-PAGE3234
monomerNeurospora crassa-1 * 50000-60000, SDS-PAGE3237
monomerEmericella nidulans-1 * 60000, SDS-PAGE3238
monomerNeurospora crassa--3238
monomerBacillus megaterium-1 * 61000, SDS-PAGE3249
monomerTrypanosoma bruceiQ9NG181 * 60557, deduced from nucleotide sequence651058
monomerSchizosaccharomyces pombeP366231 * 23700652846
tetramerSaccharomyces cerevisiae-crystal structure; identical subunits of 4 * 246 amino acids3216
tetramerSchizosaccharomyces pombe-4 * 23678, chromosomal enzyme, 4 * 23669, mutants H196Q and H151Q, 4 * 23668, mutant H163Q, mass spectrometry3221
tetramerStreptomyces coelicolor-4 * 28000, SDS-PAGE3229
tetramerSaccharomyces cerevisiae, Schizosaccharomyces pombe-4 * 27000, SDS-PAGE649656
tetramerMethanocaldococcus jannaschii-4 * 45200, deduced from nucleotide sequence651372
tetramerPyrococcus furiosus-4 * 45300, deduced from nucleotide sequence651372
monomerArchaeoglobus fulgidus-1 * 44100, calculated, 1 * 48000, SDS-PAGE of His-tagged protein679715
additional informationHomo sapiens-heterodimer structure of phosphoglycerate mutase/bisphosphoglycerate mutase crystallization data660903
additional informationSaccharomyces cerevisiae-molecular dynamics simulation reveals that the enzyme interacts with its C-terminal domain with enolase, suggesting a direct transfer mechanism of substrate680944

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
phosphoproteinSulfolobus solfataricusQ980A0autophosphorylation at Ser59651716

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
protein is composed of two structural and functiional domains, the phosphatase and the transferase. Comparison with the structurally similar domains of in Bacillus stearothermophilusBacillus anthracisQ81X77678734
crystals of phosphohistidine activated dPGM are grown from hanging drops from a protein solution containing 15 mg/ml dPGM in 20 mM Tris-HCl, pH 8.0, with 100 mM NaCl and a reservoir comprising 100 mM Tris-HCl, pH 8.75, 200 mM Li2SO4 and 20% polyethylene glycol 4000, crystals diffrakt to 1.25 A resolutionEscherichia coli-652877
crystals of iPGM complexed with 3-phosphoglycerate and Mn2+ at 1.9 A resolutionGeobacillus stearothermophilus-650970
crystals of wild-type and S62A mutant at 1.4 A resolutionGeobacillus stearothermophilus-652915
methionyl and selenomethionyl phosphoglycerate mutase, vapor drop hanging diffusion, mixing equal volumes of protein solution, i.e. 50 mg/ml protein in 150 mM 3-phosphoglycerate, pH 7.4 and reservoir solution containing 2 M ammonium sulfate, 25 mM zinc acetate, 20 mM cesium chloride, 15 mM 2-mercaptoethanol, 3% polyethylene glycol 200 and 50 mM Tris-HCl, pH 7.4, crystals diffract to 2.5 A resolutionGeobacillus stearothermophilus-653052
in complex with citrate, heterodimer structure of phosphoglycerate mutase/bisphosphoglycerate mutaseHomo sapiens-660903
modeling study of enzyme in complex with inhibitor 1-benzyl 4-[(3R,4R,6R)-6-[1-(hex-5-ynoyloxy)-1-methylethyl]-1-oxaspiro[2.5]oct-4-yl] (2R)-2-(2,3-dihydro-1H-indol-3-ylmethyl)butanedioateHomo sapiens-681851
crystals of iPGAM complexed with 3-phosphoglycerate and Co2+, hanging-drop vapor diffusion, crystallization drops contain equal volumes of reservoir and enzyme solution, 5 mg/ml iPGAM, 1.5 mM 3-phosphoglycerate, 50 mM NaCl, 0.01 mM CoCl2 in 20 mM TEA buffer, pH 7.4, crystals diffract to 1.9 ALeishmania mexicana-649202
iPGAM crystallized with 3-phosphoglycerate or 2-phosphoglycerate at high and low cobalt concentrations (4 mM and 0.01 mM), hanging drop vapor diffusion method, using 0.08 M ammonium acetate, 0.04 M trisodium citrate dihydrate pH 6.0, and 24% (w/v) PEG 4000Leishmania mexicana-705169
C-terminal phosphoglycerate mutase domain of mouse Sts-1, crystallization in space group C2 with two different crystal forms. Data of native and selenomethionine proteinMus musculus-677393
both native and selenomethionine-labelled proteinMycobacterium tuberculosis-660633
recombinant protein with His6-tagMycobacterium tuberculosis-660610
space group R32, resolution of 2.2 APyrococcus horikoshii-677357
crystal structure at 2.12 a resolutionSaccharomyces cerevisiae-652790
crystal structure; sitting drop method, equal volumes of protein solution at a concentration of 10 mg/ml and well solution are mixed, well solution contains 60 mM Tris-HCl, pH 8.65, 120 mM lithium sulfate and 22-24% polyethylene glycol 4000, protein solution contains 1 mM inositol hexakisphosphate, crystals diffract to 2.3 A resolutionSaccharomyces cerevisiae-3216
crystallization of PGAM complexed with inositol hexakisphosphate and benzene hexacarboxylate, crystal structures at 2.5-2.8 A resolutionSaccharomyces cerevisiae-652799
hanging drop, 10 mg/ml ScPGM, 55% ammonium sulfate in 10 mM imidazole buffer, pH 6.8, 1 mM 3-phosphoglycerate, crystals of ScPGM complexed with 3-phosphoglycerate diffract to 1.7 ASaccharomyces cerevisiae-649101
-Triticum aestivum-3252

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
59.5Triticum aestivum--3259
5.5-Ricinus communis-8 h, 4°C, complete inactivation3243
610Triticum aestivum--3252
6.8-Ricinus communis-rapid inactivation3243
11-Ricinus communis-24 h, 4°C, 15% loss of activity3243

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
30-Hyphomicrobium sp.--3253
30-Pseudomonas sp.-30 min, 38% loss of activity in absence of cofactor3253
45-Homo sapiens-wild-type, 1 h, 10% loss of activity, mutant M230I, 20 min, 50% loss of activity, 1 h, 90% loss of activity. In presence of 2,3-bisphosphoglycerate, both forms remain stable661261
50-Ricinus communis-plastidic enzyme: 50 min, 50% loss of activity, cytosolic enzyme: 125 min, 50% loss of activity, no protection by 2-phosphoglycerate, 3-phosphoglycerate, 2,3-bisphosphoglycerate, phosphate3243
5560Gallus gallus, Oryctolagus cuniculus, Saccharomyces cerevisiae, Sus scrofa-neutral pH, presence of ammonium sulfate or 2,3-diphosphoglycerate, stable for several min3214
60-Ricinus communis-plastidic enzyme: 8 min, 50% loss of activity, cytosolic enzyme: 25 min, 50% loss of activity, no protection by 2-phosphoglycerate, 3-phosphoglycerate, 2,3-bisphosphoglycerate, phosphate3243
60-Sus scrofa-MM-type isozyme very stable, BB-type and MB-type are inactivated rapidly, 2,3-diphosphoglycerate protects3248
60-Hyphomicrobium sp.-30 min, 17% loss of activity in presence of cofactor3253
60-Pseudomonas sp.-30 min, 13% loss of activity in presence of cofactor3253
60-Archaeoglobus fulgidus-120 min, no loss of activity679715
70-Archaeoglobus fulgidus-half-life 150 min in presence of Mn2+ and Mg2+. Half-life 30 min in the absence of Mn2+ and Mg2+679715
85-Archaeoglobus fulgidus-half-life 15 min in presence of Mn2+ and Mg2+679715
additional information-Gallus gallus, Saccharomyces cerevisiae, Sus scrofa-ammonium sulfate or 2,3-diphosphoglycerate stabilizes against elevated temperatures3258

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
rapid decrease in activity when no stabilizer is added. In presence of NaCl, CoCl2, and imidazole, stable for 1 month at 4°CLeishmania mexicanaQ86N96661634
PMSF increases the stability during purification procedureNeurospora crassa-3237
unstable to 8 M ureaOryctolagus cuniculus-3214
loss of 45% of mutase activity after treatment with thermolysinSaccharomyces cerevisiae-649656
unstable to 8 M ureaSaccharomyces cerevisiae-3214
little effect of the protease thermolysin on enzyme activitySchizosaccharomyces pombe-652799
relatively resistant to short periods of treatment with thermolysin, both mutase and phosphatase activity decline at the same rate, approx. 40% loss of activity after 120 min treatment with thermolysinSchizosaccharomyces pombe-649656

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-20°C, 10 mM Tris-HCl buffer, pH 8.0Emericella nidulans-3238
-20°C, 50% v/v glycerol, less than 50% loss of activity in 2 monthsEntamoeba histolytica-661689
4°C, saturated ammonium sulfate, pH 7.0, at least 1 month stableHomo sapiens-3254
-20°C, 10 mM sodium phosphate buffer, pH 7.0, 5 mM MgCl2, 2 mM 2-mercaptoethanol, 13% loss of activity in 1 weekHyphomicrobium sp.-3253
-20°C, 10 mM sodium phosphate buffer, pH 7.0, 5 mM MgCl2, 2 mM 2-mercaptoethanol, 10% loss of activity in 1 weekPseudomonas sp.-3253
-20°C, potassium phosphate buffer, pH 7.2, 20-25% glycerol, 1 month, no loss of activityRicinus communis-3243
-20°CSaccharomyces cerevisiae, Triticum aestivum-3215
0-4°C, ammonium sulfate suspension, pH 7.2Triticum aestivum-3252
-20°C, 6 months, 10% loss of activityZea mays-3234

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
recombinant proteinBacillus anthracisQ81X77678734
-Bacillus megaterium-3249
partialy purifiedBacillus subtilis, Clostridium perfringens-650753
HiTrap nickel chelating column chromatography and HiTrap Q column chromatographyDirofilaria immitisF4ZE01716984
-Emericella nidulans-3238
-Escherichia coli-3260
recombinant dPGMEscherichia coli-652877
-Gallus gallus-3258
recombinant iPGMGeobacillus stearothermophilus-650970
recombinant phosphoglycerate mutaseGeobacillus stearothermophilus-652915, 653052
-Homo sapiens-3245
additional activity: 2,3-diphosphoglycerate phosphataseHomo sapiens-3254
erythrocytes, enzyme has activities of bisphosphoglyceromutase and bisphosphoglycerate phosphataseHomo sapiens-3251
-Hyphomicrobium sp.-3253
metal affinity Talon column chromatographyLeishmania mexicana-705169
recombinant iPGAMLeishmania mexicana-649202
recombinant iPGMMethanocaldococcus jannaschii-651372
partialy purifiedMicrococcus luteus-650753
recombinant protein with His6-tagMycobacterium tuberculosis-660610
-Neurospora crassa-3237
-Oryctolagus cuniculus-3247
MM-type isozyme of muscleOryctolagus cuniculus-3242
-Oryza sativa-3259
partialy purifiedPlanococcus citreus-650753
-Pseudomonas sp.-3253
recombinant iPGMPyrococcus furiosus-651372
recombinant protein expressed in Escherichia coliPyrococcus horikoshii-677357
MM-type isozyme and M-subunit from skeletal muscle, BB-type isozyme and B-subunit from brainRattus norvegicus-3236
-Ricinus communis-3228, 3243
-Saccharomyces cerevisiae-3216, 3230, 3258, 652799
additional activities: bisphosphoglyceromutase, 2,3-diphosphoglycerophosphataseSaccharomyces cerevisiae-3257
ammonium sulfate, CM cellulose, Superose 12Saccharomyces cerevisiae-649101
recpmbinant PGAMSaccharomyces cerevisiae-649656
-Schizosaccharomyces pombe-652799, 652846
recombinant PGAMSchizosaccharomyces pombe-649656
partialy purifiedSporosarcina ureae, Staphylococcus saprophyticus-650753
-Streptomyces coelicolor-3229
partialy purifiedStreptomyces coelicolor-650753
partially purifiedSulfolobus solfataricusQ980A0651716
-Sus scrofa-3246, 3258
MM-type, BB-type, MB-type isozymes, these enzymes also show glycerate 2,3-diphosphate synthase and glycerate 2,3-diphosphate phosphatase activitySus scrofa-3248
-Triticum aestivum-3244, 3252, 3259
recombinant iPGAMTrypanosoma bruceiQ9NG18651058
amylose column chromatographyWolbachia sp.Q5GSN3694538
HiTrap nickel chelating column chromatography and HiTrap Q column chromatographyWolbachia sp.F4ZE02716984
-Zea mays-3234
-Zymomonas mobilis-3241

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
expression in Escherichia coli with His-tagArchaeoglobus fulgidus-679715
expression in Escherichia coliBacillus anthracisQ81X77678734
expression in Escherichia coli with His6-tagBrugia malayiQ4VWF8662259
expression in Escherichia coli with His6-tagCaenorhabditis elegansG5EFZ1662259
expressed in Escherichia coli C2566/T7 cellsDirofilaria immitisF4ZE01716984
-Entamoeba histolytica-661689
-Escherichia coli-652877
expression in Escherichia coliGeobacillus stearothermophilus-650970, 652915
expression of native and selenomethionyl phosphoglycerate mutase in Escherichia coliGeobacillus stearothermophilus-653052
isozyme PGAM-BHomo sapiens-3261
isozyme PGAM-MHomo sapiens-3262
expression in Escherichia coliLeishmania mexicana-649202
expression in Escherichia coli with C-terminal His-tagLeishmania mexicanaQ86N96661634
His-tagged enzyme is expressed in Escherichia coli BL21 cellsLeishmania mexicana-705169
expression in Escherichia coliMethanocaldococcus jannaschii-651372
C-terminal phosphoglycerate mutase domain of mouse Sts-1, Sts-1PGM, comprised of residues 369-640 and an N-terminal His-tagMus musculus-677393
expression in Escherichia coli with His6-tagMycobacterium tuberculosis-660610
expression in Escherichia coli wtih N-terminal His6-tagMycobacterium tuberculosis-660633
-Pseudomonas syringae-3225
expression in Escherichia coliPyrococcus furiosus-651372
expression in Escherichia coliPyrococcus horikoshii-677357
-Ricinus communis-3228
-Saccharomyces cerevisiae-3230
expression in Saccharomyces cerevisiaeSaccharomyces cerevisiae-649656
overexpression in Saccharomyces cerevisaeSaccharomyces cerevisiae-652790
-Schizosaccharomyces pombe-649656
expressed in Saccharomyces cerevisiaeSchizosaccharomyces pombe-3221
expression in Saccharomyces cerevisiaeSchizosaccharomyces pombe-651088, 652846
-Streptomyces coelicolor-3229
expressed in PK-15 cells; expressed in PK-15 cellsSus scrofaB5KJG2, B5KJG3693442
expression in Escherichia coliThermoplasma acidophilumQ9HL27679715
expression in Escherichia coliTrypanosoma bruceiQ9NG18651058
expressed in Escherichia coli (inactive unsoluble protein) and Kluyveromyces lactis (active enzyme)Wolbachia sp.Q5GSN3694538
expressed in Escherichia coli C2566/T7 cellsWolbachia sp.F4ZE02716984
-Zea mays-3226

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
phosphoglycerate mutase 1 is markedly upregulated in hepatocellular carcinomaHomo sapiens-705672

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
D12NGeobacillus stearothermophilus-no activity650970
H123NGeobacillus stearothermophilus-3% of wild-type activity650970
H125NGeobacillus stearothermophilus-67% of wild-type activity650970
H128NGeobacillus stearothermophilus-20% of wild-type activity650970
H407NGeobacillus stearothermophilus-no activity650970
H42NGeobacillus stearothermophilus-91% of wild-type activity650970
H42N/H128NGeobacillus stearothermophilus-8% of wild-type activity650970
H445NGeobacillus stearothermophilus-18% of wild-type activity650970
H462NGeobacillus stearothermophilus-0.3% of wild-type activity650970
H66NGeobacillus stearothermophilus-2% of wild-type activity650970
R261LGeobacillus stearothermophilus-no activity650970
S62AGeobacillus stearothermophilus-no activity650970
S62AGeobacillus stearothermophilus-no phosphoglycerate mutase activity652915
K100AHomo sapiens-no covalent modification by inhibitor 1-benzyl 4-[(3R,4R,6R)-6-[1-(hex-5-ynoyloxy)-1-methylethyl]-1-oxaspiro[2.5]oct-4-yl] (2R)-2-(2,3-dihydro-1H-indol-3-ylmethyl)butanedioate681851
M230IHomo sapiens-mutation identified in a patient with hereditary sperocytosis and 50% deficiency of enzyme activity in red blood cells. Enzyme shows abnormal behaviour on ion-exchange chromatography and is more thermo-labile than wild-type661261
M230IHomo sapiens-mutation identified in a patient with non-spherocytic anemia. 50% reduction of enzyme activity, with normal levels of enzyme protein. Mutation results in decrease of glycolytic metabolites, with the exception of hexose phosphates. In contrast, lactate levels are increased661847
A60SSaccharomyces cerevisiae-69% of wild-type activity652790
E86QSaccharomyces cerevisiae-1% of wild-type activity652790
H181ASaccharomyces cerevisiae-His181 is substituted by Ala in site-directed mutagenesis. The resulting enzyme has a reduced activity and still requires 2,3-diphosphoglycerate. His181 seems to be important for cofactor-binding3230
K246GSaccharomyces cerevisiae-mutant enzymes in which Ser11 is replaced by Gly, i.e. S11G and Lys246 by Gly, i.e. K246G do not have significantly altered kinetic values3231
L245GSaccharomyces cerevisiae-39% of wild-type mutase activity, 111% of wild-type phosphatase activity649656
L245G/L246GSaccharomyces cerevisiae-105% of wild-type mutase activity, 111% of wild-type phosphatase activity649656
L246GSaccharomyces cerevisiae-98% of wild-type mutase activity, 122% of wild-type phosphatase activity649656
S11ASaccharomyces cerevisiae-4% of wild-type activity652790
S11GSaccharomyces cerevisiae-mutant enzymes in which Ser11 is replaced by Gly, i.e. S11G and Lys246 by Gly, i.e. K246G do not have significantly altered kinetic values3231
E93DSchizosaccharomyces pombe-less than 1% of wild-type activity651088
E93DSchizosaccharomyces pombeP366233D structure in solution obtained with NMR652846
R120QSchizosaccharomyces pombe-59% of wild-type activity651088
R120Q/R121QSchizosaccharomyces pombe-62% of wild-type activity651088
R121QSchizosaccharomyces pombe-12% of wild-type activity651088
R14QSchizosaccharomyces pombe-less than 1% of wild-type activity651088
R94QSchizosaccharomyces pombe-1% of wild-type activity651088
S62ASchizosaccharomyces pombe-loss of activity during purification651088
additional informationCaenorhabditis elegansG5EFZ1reduction of enzyme activity by RNA interference leads to embroynic lethality, larval lethylity, and abnormal body morphology662259
H23AThermoplasma acidophilumQ9HL27no enzymic activity. Like wild-type, mutant forms a dimer679715
additional informationTrypanosoma brucei-down-regulation of enzyme steady state levels by RNAi correlates with a marked reduction of enzyme activity. Enzyme is required for cell growth in procyclic Trypanosoma brucei682237

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
reactivation of EDTA-treated enzyme by Mn2+. Several activation-deactivation cycles can be elicitedBacillus megaterium-677798
metal ions do not reactivate the enzyme after denaturation with guanidine-HClEmericella nidulans-3238
inactivation by EDTA is reversible by incubation with CoCl2, but not MnCl2, FeSO4, CuSo4,NiCl2, ZnCl2Leishmania mexicanaQ86N96661634
metal ions do not reactivate the enzyme after denaturation with guanidine-HClNeurospora crassa-3238
renatured after denaturation with guanidine-HClOryctolagus cuniculus, Saccharomyces cerevisiae-3240
inhibition of enzyme by vanadate may be partially reversed by EDTAThermoplasma acidophilumQ9HL27679715
metal ions do not reactivate the enzyme after denaturation with guanidine-HClTriticum aestivum-3238

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
medicineHomo sapiens-analysis of enzyme mutations found in some patients660903
medicineHomo sapiens-mutation M230I is identified in a patient with hereditary sperocytosis and 50% deficiency of enzyme activity in red blood cells. Enzyme shows abnormal behaviour on ion-exchange chromatography and is more thermo-labile than wild-type661261
medicineHomo sapiens-mutation M230I identified in a patient with non-spherocytic anemia. Enzyme activity is reduced by 50%, with normal levels of enzyme protein. Mutation results in decrease of glycolytic metabolites, with the exception of hexose phosphates. In contrast, lactate levels are increased661847
medicineHomo sapiens-PGAM1 plays an important role in hepatocarcinogenesis, is a potential diagnostic biomarker as well as an attractive therapeutic target for hepatocellular carcinoma705672
medicineOryctolagus cuniculus-both in erythroblasts and reticulocytes, increase in enzyme activity and mRNA level after application of triiodothyronine or induction of hypoxia by 90% nitrogen/10% oxygen. Propylthiouracil produces a decrease in enzyme activity661851
medicineRattus norvegicus-PGAM1 may have a pathological role of vascular invasion into cancerous tissue694050
medicineRattus norvegicus-the anti-PGAM1 antibody is a marker of autoimmune hepatitis and a nonspecific marker of central nervous system autoimmune diseases705270
medicineWolbachia sp.Q5GSN3drug target for novel anti-filarial therapies that selectively target the Wolbachia endosymbiont of Brugia malayi694538

DISEASETITLE OF PUBLICATIONLINK TO PUBMED
Abruptio PlacentaeThe association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies. PubMed
AdenocarcinomaPhosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and enolase activity and isoenzymes in lung, colon and liver carcinomas. PubMed
AnemiaPhosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies. PubMed
Anemia[Chronic oral toxicity study of proglumetacin maleate in beagle dogs] PubMed
Angina PectorisPhosphoglucomutase activity as a novel biomarker in patients with acute myocardial infarction. PubMed
Arthritis[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (2). Analgesic and antipyretic effects] PubMed
Arthritis, Experimental[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (1). Anti-inflammatory effects] PubMed
AstrocytomaPhosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and creatine kinase activity and isoenzymes in human brain tumours. PubMed
AtherosclerosisProteomic characterization of rat liver exposed to 2,3,7,8-tetrachlorobenzo-p-dioxin. PubMed
Brain NeoplasmsPhosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and creatine kinase activity and isoenzymes in human brain tumours. PubMed
Breast Neoplasms[Echogenic phospholipids-based gas-filled microbubbles as delivery system of antisense oligodeoxynucleotides] PubMed
Carcinoid TumorPhosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and enolase activity and isoenzymes in lung, colon and liver carcinomas. PubMed
CarcinomaAntitumor and antimetastatic activity of the immunoadjuvant peptidoglycan monomer PGM in mice bearing MCa mammary carcinoma. PubMed
CarcinomaEffects of dimethyltriazenes combined with surgery and non-specific immunotherapy in mice bearing Lewis lung carcinoma lines. PubMed
CarcinomaEffects of L-(adamant-2-yl)glycyl-L-alanyl-d-isoglutamine on the antitumor action of cyclophosphamide, 5-fu, Cisplatin and dacarbazine on advanced carcinomas of the mouse. PubMed
CarcinomaEffects of postsurgical immunotherapy with PGM in mice bearing Lewis lung carcinoma treated with p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt. PubMed
CarcinomaPhosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and enolase activity and isoenzymes in lung, colon and liver carcinomas. PubMed
CarcinomaPhosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase, creatine kinase and enolase activity and isoenzymes in breast carcinoma. PubMed
Carcinoma, HepatocellularQuantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. PubMed
Carcinoma, Lewis LungEffects of dimethyltriazenes combined with surgery and non-specific immunotherapy in mice bearing Lewis lung carcinoma lines. PubMed
Carcinoma, Lewis LungEffects of L-(adamant-2-yl)glycyl-L-alanyl-d-isoglutamine on the antitumor action of cyclophosphamide, 5-fu, Cisplatin and dacarbazine on advanced carcinomas of the mouse. PubMed
Carcinoma, Lewis LungEffects of postsurgical immunotherapy with PGM in mice bearing Lewis lung carcinoma treated with p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt. PubMed
Carcinoma, Squamous CellPhosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and enolase activity and isoenzymes in lung, colon and liver carcinomas. PubMed
Central Nervous System DiseasesHigh prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases. PubMed
Chronic Pain[Neurophysiological mechanisms of pain perception] PubMed
Communicable DiseasesInfectious disease 1947-1987. A PGM retrospective. PubMed
CoughInfluence of simulated mucus on cough sounds in cats. PubMed
CystsPrenatal pseudocysts of the germinal matrix in preterm infants. PubMed
Dementia[Indicators of early Alzheimer dementia in family practice. Development and validation of the Observation List of Early Symptoms of Dementia (OLD)] PubMed
Dermatitis, AtopicGenetic investigations in atopic dermatitis. PubMed
Diabetic NeuropathiesPartial deficiency of phosphoglycerate mutase with diabetic polyneuropathy: the first Japanese patient. PubMed
Fetal DeathPrepartum changes of plasma concentrations of prostaglandin F and 13,14-dihydro-15-ketoprostaglandin metabolites in pregnant animals exposed to Sarcocystis cruzi or Campylobacter fetus. PubMed
fructose-bisphosphatase deficiencyEffect of phosphoglycerate mutase and fructose 1,6-bisphosphatase deficiency on symbiotic Burkholderia phymatum. PubMed
fructose-bisphosphate aldolase deficiencyTarui disease and distal glycogenoses: clinical and genetic update. PubMed
Gallstones[A study on the mechanism of the choleretic effect of proglumide] PubMed
Gallstones[The effect of proglumide on gallstone formation in guinea pigs] PubMed
GlioblastomaPhosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and creatine kinase activity and isoenzymes in human brain tumours. PubMed
Glioma[Proteomic analysis of rat astrocytes and C6 glioma cells] PubMed
glucose-6-phosphate dehydrogenase deficiencyRed cell phosphoglucomutase (PGM)-deficiency: hereditary defect of the PGM1-locus. PubMed
Glucosephosphate Dehydrogenase DeficiencyRed cell phosphoglucomutase (PGM)-deficiency: hereditary defect of the PGM1-locus. PubMed
Glycogen Storage DiseaseCARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells. PubMed
Glycogen Storage DiseaseClinical application of massively parallel sequencing in the molecular diagnosis of glycogen storage diseases of genetically heterogeneous origin. PubMed
Glycogen Storage DiseaseMetabolic myopathies. PubMed,  PubMed
Glycogen Storage DiseaseMuscle phosphoglycerate mutase deficiency revisited. PubMed
Glycogen Storage DiseaseTarui disease and distal glycogenoses: clinical and genetic update. PubMed
Glycogen Storage Disease Type VA nonischemic forearm exercise test for McArdle disease. PubMed
HemochromatosisHereditary hemochromatosis restores the virulence of plague vaccine strains. PubMed
Hepatitis[Phosphoglyceromutase activity of the blood in human viral hepatitis.] PubMed
Hepatitis, AutoimmuneSerum proteomic-based analysis for the identification of a potential serological marker for autoimmune hepatitis. PubMed
HypersensitivityAllergy and immunology 1947-1987. A PGM retrospective. PubMed
HyperthyroidismProteomic characterization of rat liver exposed to 2,3,7,8-tetrachlorobenzo-p-dioxin. PubMed
InfectionAbsence of inflammation and pneumonia during infection with non-pigmented Yersinia pestis reveals new role for the pgm locus in pathogenesis. PubMed
InfectionComparative proteome analysis of splenic lymphocytes in senescence-accelerated mice. PubMed
InfectionCurrent progress in proteomic study of hepatitis C virus-related human hepatocellular carcinoma. PubMed
InfectionHybrids between Schistosoma haematobium and S. mattheei and their identification by isoelectric focusing of enzymes. PubMed
InfectionPrepartum changes of plasma concentrations of prostaglandin F and 13,14-dihydro-15-ketoprostaglandin metabolites in pregnant animals exposed to Sarcocystis cruzi or Campylobacter fetus. PubMed
InfectionThe enzyme phosphoglucomutase (Pgm) is required by Salmonella enterica serovar Typhimurium for O-antigen production, resistance to antimicrobial peptides and in vivo fitness. PubMed
Insulin ResistancePartial deficiency of phosphoglycerate mutase with diabetic polyneuropathy: the first Japanese patient. PubMed
l-lactate dehydrogenase deficiencyMyopathies due to enzyme deficiencies. PubMed
l-lactate dehydrogenase deficiencyPhosphoglycerate kinase deficiency: another cause of recurrent myoglobinuria. PubMed
Leishmaniasis, VisceralA preliminary isoenzyme study on five species of phlebotomine sandflies in China. PubMed
Leishmaniasis, VisceralLeishmaniasis in Brazil. XXII: Characterization of Leishmania from man, dogs and the sandfly Lutzomyia longipalpis (Lutz & Neiva, 1912) isolated during an outbreak of visceral leishmaniasis in Santarém, Pará State. PubMed
Leishmaniasis, VisceralLeishmaniasis in Brazil: XVIII. Further evidence incriminating the fox Cerdocyon thous (L) as a reservoir of Amazonian visceral leishmaniasis. PubMed
Leishmaniasis, Visceral[The identification of Leishmania isolates obtained from patients and dogs with visceral leishmaniasis in the Turkmen SSR] PubMed
LeukemiaRegulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase. PubMed
Liver NeoplasmsQuantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. PubMed
Lung NeoplasmsLarge meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene. PubMed
MelanomaImmunotherapy of B-16 melanoma with peptidoglycan monomer. PubMed
MeningiomaPhosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and creatine kinase activity and isoenzymes in human brain tumours. PubMed
Menkes Kinky Hair SyndromeA phosphoglycerate mutase brain isoform (PGAM 1) pseudogene is localized within the human Menkes disease gene (ATP7 A). PubMed
Mitochondrial MyopathiesMetabolic myopathies. PubMed
Multiple SclerosisHigh prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases. PubMed
Muscle CrampExercise-induced cramp, myoglobinuria, and tubular aggregates in phosphoglycerate mutase deficiency. PubMed
Muscle CrampMolecular basis of muscle phosphoglycerate mutase (PGAM-M) deficiency in the Italian kindred. PubMed
Muscle CrampMuscle phosphoglycerate mutase deficiency with tubular aggregates: effect of dantrolene. PubMed
Muscle CrampMuscle phosphoglycerate mutase deficiency: a study of a family with metabolic myopathy. PubMed
Muscle CrampPartial deficiency of phosphoglycerate mutase with diabetic polyneuropathy: the first Japanese patient. PubMed
Muscular DiseasesDecreased oxidative phosphorylation and PGAM deficiency in horses suffering from atypical myopathy associated with acquired MADD. PubMed
Muscular DiseasesEffect of fuels on exercise capacity in muscle phosphoglycerate mutase deficiency. PubMed
Muscular DiseasesGenomic analysis of five chromosome 7p deletion patients with Greig cephalopolysyndactyly syndrome (GCPS). PubMed
Muscular DiseasesHuman muscle phosphoglycerate mutase deficiency: newly discovered metabolic myopathy. PubMed
Muscular DiseasesIsozyme patterns and protein profiles in neuromuscular disorders. PubMed
Muscular DiseasesManifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific phosphoglycerate mutase (PGAM-M) gene. PubMed
Muscular DiseasesMolecular genetic studies in muscle phosphoglycerate mutase (PGAM-M) deficiency. PubMed
Muscular DiseasesMuscle phosphoglycerate mutase deficiency: a study of a family with metabolic myopathy. PubMed
Muscular DiseasesPhysiologic assessment of phosphoglycerate mutase deficiency: incremental exercise test. PubMed
Muscular DiseasesUnusual presentation of phosphoglycerate mutase deficiency due to two different mutations in PGAM-M gene. PubMed
Muscular DystrophiesPlasma phosphoglycerate mutase as a marker of muscular dystrophy. PubMed
Muscular Dystrophy, DuchennePlasma phosphoglycerate mutase as a marker of muscular dystrophy. PubMed
Myocardial InfarctionActivity of phosphoglycerate mutase and its isoenzymes in serum after acute myocardial infarction. PubMed
Myocardial InfarctionInactivation of phosphoglycerate mutase and creatine kinase isoenzymes in human serum. PubMed
Myocardial InfarctionPhosphoglucomutase activity as a novel biomarker in patients with acute myocardial infarction. PubMed
Myocardial IschemiaPhosphoglucomutase activity as a novel biomarker in patients with acute myocardial infarction. PubMed
MyoglobinuriaExercise-induced cramp, myoglobinuria, and tubular aggregates in phosphoglycerate mutase deficiency. PubMed
MyoglobinuriaMetabolic causes of myoglobinuria. PubMed
MyoglobinuriaMetabolic myopathies. PubMed
MyoglobinuriaMolecular basis of muscle phosphoglycerate mutase (PGAM-M) deficiency in the Italian kindred. PubMed
MyoglobinuriaMuscle phosphoglycerate mutase (PGAM) deficiency: a second case. PubMed
MyoglobinuriaMuscle phosphoglycerate mutase deficiency: a study of a family with metabolic myopathy. PubMed
MyoglobinuriaPhosphoglycerate kinase deficiency: another cause of recurrent myoglobinuria. PubMed
MyoglobinuriaPhysiologic assessment of phosphoglycerate mutase deficiency: incremental exercise test. PubMed
MyoglobinuriaUnusual presentation of phosphoglycerate mutase deficiency due to two different mutations in PGAM-M gene. PubMed
Myoglobinuria[Myoglobinuria due to enzyme abnormalities in glycolytic pathway--especially lactate dehydrogenase M subunit deficiency] PubMed
Neoplasm MetastasisEffects of L-(adamant-2-yl)glycyl-L-alanyl-d-isoglutamine on the antitumor action of cyclophosphamide, 5-fu, Cisplatin and dacarbazine on advanced carcinomas of the mouse. PubMed
Neoplasm MetastasisImmunotherapy of B-16 melanoma with peptidoglycan monomer. PubMed
NeoplasmsAntitumor and antimetastatic activity of the immunoadjuvant peptidoglycan monomer PGM in mice bearing MCa mammary carcinoma. PubMed
NeoplasmsAssociation of C-terminal region of phosphoglycerate mutase with glycolytic complex regulates energy production in cancer cells. PubMed
NeoplasmsEffects of dimethyltriazenes combined with surgery and non-specific immunotherapy in mice bearing Lewis lung carcinoma lines. PubMed
NeoplasmsEffects of L-(adamant-2-yl)glycyl-L-alanyl-d-isoglutamine on the antitumor action of cyclophosphamide, 5-fu, Cisplatin and dacarbazine on advanced carcinomas of the mouse. PubMed
NeoplasmsEffects of postsurgical immunotherapy with PGM in mice bearing Lewis lung carcinoma treated with p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt. PubMed
NeoplasmsEvidence for an alternative glycolytic pathway in rapidly proliferating cells. PubMed
NeoplasmsG-6-PD and PGM phenotypes of 16 continuous human tumor cell lines. Evidence against cross-contamination and contamination by HeLa cells. PubMed
NeoplasmsImmunohistochemical expression of chromogranins A and B, prohormone convertases 2 and 3, and amidating enzyme in carcinoid tumors and pancreatic endocrine tumors. PubMed
NeoplasmsImmunohistochemical localization of Phosphoglycerate mutase in capillary endothelium of the brain and periphery. PubMed
NeoplasmsImmunotherapy of B-16 melanoma with peptidoglycan monomer. PubMed
NeoplasmsOff-target effects related to the phosphorothioate modification of nucleic acids. PubMed
NeoplasmsPhosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and enolase activity and isoenzymes in lung, colon and liver carcinomas. PubMed
NeoplasmsPhosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase, creatine kinase and enolase activity and isoenzymes in breast carcinoma. PubMed
NeoplasmsPhosphoglycerate mutase-derived polypeptide inhibits glycolytic flux and induces cell growth arrest in tumor cell lines. PubMed
NeoplasmsProtection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization. PubMed
NeoplasmsProteomic analysis of secreted proteins of non-small cell lung cancer. PubMed
NeoplasmsTarget discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. PubMed
NeoplasmsTwo roles for Ia in antigen-specific T lymphocyte activation. PubMed
Otitis Media with EffusionRole of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear. PubMed
Ovarian Hyperstimulation SyndromeFactor V Leiden and prothrombin gene G20210A mutation and in vitro fertilization: prospective cohort study. PubMed
PainMuscle phosphoglycerate mutase deficiency: a study of a family with metabolic myopathy. PubMed
PainParalysis of innervated cultured human muscle fibers affects enzymes differentially. PubMed
Pain[Neurophysiological mechanisms of pain perception] PubMed
Pain[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (2). Analgesic and antipyretic effects] PubMed
ParalysisParalysis of innervated cultured human muscle fibers affects enzymes differentially. PubMed
phosphoglycerate kinase deficiencyPhosphoglycerate kinase deficiency: another cause of recurrent myoglobinuria. PubMed
phosphoglycerate mutase deficiencyA nonischemic forearm exercise test for McArdle disease. PubMed
phosphoglycerate mutase deficiencyDecreased oxidative phosphorylation and PGAM deficiency in horses suffering from atypical myopathy associated with acquired MADD. PubMed
phosphoglycerate mutase deficiencyEffect of fuels on exercise capacity in muscle phosphoglycerate mutase deficiency. PubMed
phosphoglycerate mutase deficiencyEffect of phosphoglycerate mutase deficiency on heterotrophic and autotrophic carbon metabolism of Alcaligenes eutrophus. PubMed
phosphoglycerate mutase deficiencyExercise-induced cramp, myoglobinuria, and tubular aggregates in phosphoglycerate mutase deficiency. PubMed
phosphoglycerate mutase deficiencyGlycolytic defects in muscle: aspects of collaboration between basic science and clinical medicine. PubMed
phosphoglycerate mutase deficiencyHuman muscle phosphoglycerate mutase deficiency: newly discovered metabolic myopathy. PubMed
phosphoglycerate mutase deficiencyInfantile muscle glycogen storage disease: phosphoglucomutase deficiency with decreased muscle and serum carnitine levels. PubMed
phosphoglycerate mutase deficiencyManifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific phosphoglycerate mutase (PGAM-M) gene. PubMed
phosphoglycerate mutase deficiencyMetabolic causes of myoglobinuria. PubMed
phosphoglycerate mutase deficiencyMolecular genetic studies in muscle phosphoglycerate mutase (PGAM-M) deficiency. PubMed
phosphoglycerate mutase deficiencyMuscle phosphoglycerate mutase (PGAM) deficiency in the first Caucasian patient: biochemistry, muscle culture and 31P-MR spectroscopy. PubMed
phosphoglycerate mutase deficiencyMuscle phosphoglycerate mutase (PGAM) deficiency: a second case. PubMed
phosphoglycerate mutase deficiencyMuscle phosphoglycerate mutase deficiency revisited. PubMed
phosphoglycerate mutase deficiencyMuscle phosphoglycerate mutase deficiency with tubular aggregates: effect of dantrolene. PubMed
phosphoglycerate mutase deficiencyMuscle phosphoglycerate mutase deficiency. PubMed
phosphoglycerate mutase deficiencyMuscle phosphoglycerate mutase deficiency: a study of a family with metabolic myopathy. PubMed
phosphoglycerate mutase deficiencyPartial deficiency of phosphoglycerate mutase with diabetic polyneuropathy: the first Japanese patient. PubMed
phosphoglycerate mutase deficiencyPhosphoglycerate mutase deficiency: case report of a manifesting heterozygote with a novel E154K mutation and very late onset. PubMed
phosphoglycerate mutase deficiencyPhosphorus magnetic resonance spectroscopy of partially blocked muscle glycolysis. An in vivo study of phosphoglycerate mutase deficiency. PubMed
phosphoglycerate mutase deficiencyPhysiologic assessment of phosphoglycerate mutase deficiency: incremental exercise test. PubMed
phosphoglycerate mutase deficiencyProgress and problems in muscle glycogenoses. PubMed
phosphoglycerate mutase deficiencyRed cell phosphoglucomutase (PGM)-deficiency: hereditary defect of the PGM1-locus. PubMed
phosphoglycerate mutase deficiencyUnusual presentation of phosphoglycerate mutase deficiency due to two different mutations in PGAM-M gene. PubMed
phosphoglycerate mutase deficiency[A case of adult onset phosphoglucomutase deficiency] PubMed
phosphoglycerate mutase deficiency[Muscle phosphoglycerate mutase deficiency] PubMed
phosphoglycerate mutase deficiency[Phosphoglycerate mutase deficiency] PubMed
phosphorylase deficiencyMetabolic causes of myoglobinuria. PubMed
phosphorylase kinase deficiencyMetabolic causes of myoglobinuria. PubMed
PlagueAbsence of inflammation and pneumonia during infection with non-pigmented Yersinia pestis reveals new role for the pgm locus in pathogenesis. PubMed
PlagueGenetic variations in the pgm locus among natural isolates of Yersinia pestis. PubMed
PlagueHereditary hemochromatosis restores the virulence of plague vaccine strains. PubMed
PlagueSeptic shock and nonpulmonary organ dysfunction in pneumonic plague: The role of Yersinia pestis pCD1- vs. pgm- virulence factors. PubMed
PlagueThe yersiniabactin transport system is critical for the pathogenesis of bubonic and pneumonic plague. PubMed
PlagueYersinia pestis YbtU and YbtT are involved in synthesis of the siderophore yersiniabactin but have different effects on regulation. PubMed
PlagueYersiniabactin production requires the thioesterase domain of HMWP2 and YbtD, a putative phosphopantetheinylate transferase. PubMed
Pleurisy[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (1). Anti-inflammatory effects] PubMed
PneumoniaAbsence of inflammation and pneumonia during infection with non-pigmented Yersinia pestis reveals new role for the pgm locus in pathogenesis. PubMed
PneumoniaSeptic shock and nonpulmonary organ dysfunction in pneumonic plague: The role of Yersinia pestis pCD1- vs. pgm- virulence factors. PubMed
PolyneuropathiesPartial deficiency of phosphoglycerate mutase with diabetic polyneuropathy: the first Japanese patient. PubMed
Pre-EclampsiaDifferential proteomic analysis of highly purified placental cytotrophoblasts in preeclampsia demonstrates a state of increased oxidative stress and reduced cytotrophoblast antioxidant defense. PubMed
Pre-EclampsiaThe association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies. PubMed
Pregnancy ComplicationsThe association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies. PubMed
Prostatic NeoplasmsResveratrol-induced cell growth inhibition and apoptosis is associated with modulation of phosphoglycerate mutase B in human prostate cancer cells: two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry evaluation. PubMed
QuadriplegiaAssociations between inherited thrombophilias, gestational age, and cerebral palsy. PubMed
SarcomaSheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH). PubMed
Sarcoma, AvianPhosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. PubMed
SeizuresPeony root extract upregulates transthyretin and phosphoglycerate mutase in mouse cobalt focus seizure. PubMed
SepsisSeptic shock and nonpulmonary organ dysfunction in pneumonic plague: The role of Yersinia pestis pCD1- vs. pgm- virulence factors. PubMed
Sexually Transmitted DiseasesPopulation genetics of Neisseria gonorrhoeae in a high-prevalence community using a hypervariable outer membrane porB and 13 slowly evolving housekeeping genes. PubMed
Spherocytosis, HereditaryCharacterization of the first described mutation of human red blood cell phosphoglycerate mutase. PubMed
StrokeA new stroke marker as detected by serum phosphoglycerate mutase B-type isozyme. PubMed
Suppuration[The role of the genotype in the development of suppurative inflammatory complications in trauma to the facial bones] PubMed
SyphilisTreponema pallidum 3-phosphoglycerate mutase is a heat-labile enzyme that may limit the maximum growth temperature for the spirochete. PubMed
ThrombosisFactor V Leiden and prothrombin gene G20210A mutation and in vitro fertilization: prospective cohort study. PubMed
ThrombosisPhosphoglucomutase activity as a novel biomarker in patients with acute myocardial infarction. PubMed
TuberculosisCloning, expression, purification and preliminary crystallographic data for Rv3214 (EntD), a predicted cofactor-dependent phosphoglycerate mutase from Mycobacterium tuberculosis. PubMed
TuberculosisMycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis. PubMed
TuberculosisStructural and functional analysis of Rv3214 from Mycobacterium tuberculosis, a protein with conflicting functional annotations, leads to its characterization as a phosphatase. PubMed
TuberculosisThe 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase. PubMed
Tuberculosis[A genotypic study of children ill with tuberculosis and of healthy BCG-revaccinated ones of Tuvinian nationality] PubMed
udp-galactopyranose mutase deficiencyPhosphorus magnetic resonance spectroscopy of partially blocked muscle glycolysis. An in vivo study of phosphoglycerate mutase deficiency. PubMed

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISMLINK TO PUBMEDSOURCE
3213Rose, Z.B.The enzymology of 2,3-bisphosphoglycerateAdv. Enzymol. Relat. Areas Mol. Biol.51211-2531980Gallus gallus, Homo sapiens, Oryctolagus cuniculus, Saccharomyces cerevisiae, Sus scrofa, Triticum aestivum PubMed
3214Ray, W.J.; Peck, E.J.PhosphomutasesThe Enzymes, 3rd Ed. (Boyer, P.D., ed.)6407-4771972Gallus gallus, Oryctolagus cuniculus, Saccharomyces cerevisiae, Sus scrofa, Triticum aestivum-
3215Grisolia, S.Phosphoglyceric acid mutasesMethods Enzymol.5236-2421962Saccharomyces cerevisiae, Triticum aestivum-
3216Rigden, D.J.; Alexeev, D.; Phillips, S.E.; Fothergill-Gilmore, L.A.The 2.3 A X-ray crystal structure of S. cerevisiae phosphoglycerate mutaseJ. Mol. Biol.276449-4591998Saccharomyces cerevisiae PubMed
3217Durany, N.; Joseph, J.; Cruz-Sanchez, F.F.; Carreras, J.Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and creatine kinase activity and isoenzymes in human brain tumorsBr. J. Cancer761139-11491997Homo sapiens PubMed
3218Durany, N.; Joseph, J.; Campo, E.; Molina, R.; Carreras, J.Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and enolase activity and isoenzymes in lung, colon and liver carcinomasBr. J. Cancer75969-9771997Homo sapiens PubMed
3219Price, R.M.; Nairn, J.; Price, N.C.; Fothergill-Gilmore, L.A.The reaction of phosphoglycerate mutase from Schizosaccharomyces pombe with diethylpyrocarbonateBiochem. Soc. Trans.24324S1996Schizosaccharomyces pombe PubMed
3220Durany, N.; Carreras, J.Distribution of phosphoglycerate mutase isozymes in rat, rabbit and human tissuesComp. Biochem. Physiol. B114217-2231996Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus PubMed
3221Nairn, J.; Price, N.C.; Kelly, S.M.; Rigden, D.; Fothergill-Gilmore, L.A.; Krell, T.Phosphoglycerate mutase from Schizosaccharomyces pombe: development of an expression system and characterisation of three histidine mutants of the enzymeBiochim. Biophys. Acta129669-751996Schizosaccharomyces pombe PubMed
3222Wang, J.L.; Walling, L.L.; Jauh, G.Y.; Gu, Y.Q.; Lord, E.M.Lily cofactor-independent phosphoglycerate mutase: purification, partial sequencing and immunolocalizationPlanta200343-3521996Lilium longiflorum PubMed
3223Grana, X.; Perez de la Ossa, P.; Broceno, C.; Stoecker, M.; Garriga, J.; Puigdomenech, P.; Climent, F.2,3-Bisphosphoglycerate-independent phosphoglycerate mutase is conserved among different phylogenic kingdomsComp. Biochem. Physiol. B112287-2931995Homo sapiens, More, Prunus dulcis, Zea mays PubMed
3224Kuhn, N.J.; Setlow, B.; Setlow, P.; Cammack, R.; Williams, R.Cooperative Manganese (II) activation of 3-phosphoglycerate mutase of Bacillus megaterium: a biological pH-sensing mechanism in bacterial spore formation and germinationArch. Biochem. Biophys.32035-421995Bacillus megaterium PubMed
3225Morris, V.L.; Jackson, D.P.; Grattan, M.; Ainsworth, T.; Cuppels, D.A.Isolation and sequence analysis of the Pseudomonas syringae pv. tomato gene encoding a 2,3-diphosphoglycerate-independent phosphoglyceromutaseJ. Bacteriol.1771727-17331995Pseudomonas syringae PubMed
3226Perez de la Ossa, P.; Grana, X.; Ruiz-Lozano, P.; Climent, F.Isolation and characterization of cofactor-independent phosphoglycerate mutase gene from maizeBiochem. Biophys. Res. Commun.2031204-12091994Zea mays PubMed
3227Esteller, M.; Urena, J.; Carreras, J.; Martelly, I.; Climent, F.Thyroid hormone stimulates phosphoglycerate activity and isozyme transition in rat muscle tissuesLife Sci.54533-5381994Rattus norvegicus PubMed
3228Huang, Y.; Blakeley, S.D.; McAleese, S.M.; Fothergill-Gilmore, L.A.; Dennis, D.T.Higher-plant cofactor-independent phosphoglyceromutase: purification, molecular characterization and expressionPlant Mol. Biol.231039-10531993Nicotiana tabacum, Ricinus communis PubMed
3229White, P.J.; Nairn, J.; Price, N.C.; Nimmo, H.G.; Coggins, J.R.; Hunter, I.S.Phosphoglycerate mutase from Streptomyces coelicolor A3(2): purification and characterization of the enzyme and cloning and sequence analysis of the geneJ. Bacteriol.174434-4401992Streptomyces coelicolor PubMed
3230White, M.F.; Fothergill-Gilmore, L.A.Development of a mutagenesis, expression and purification system for yeast phosphoglycerate mutaseEur. J. Biochem.207709-7141992Saccharomyces cerevisiae PubMed
3231White, M.; Fothergill-Gilmore L.A.Mutase versus synthase: the phosphoglycerate mutase family studied by protein engineeringBiochem. Soc. Trans.182571990Saccharomyces cerevisiae PubMed
3232Urena, J.M.; Egea, G.; Grana, X.; Castella, J.; Marsal, J.; Carreras, J.; Climent, F.Location of phosphoglycerate mutase in rat skeletal muscle. An immunological and biochemical studyEur. J. Cell Biol.51151-1561990Rattus norvegicus PubMed
3233Edwards, R.J.; Carter, N.D.; Jeffery, S.; Yates, S.Purification of human muscle phosphoglycerate mutase by fast protein liquid chromatography based on hydrophobic interactionsJ. Chromatogr.490424-4311989Homo sapiens PubMed
3234Grana, X.; Urena, J.; Ludevid, D.; Carreras, J.; Climent, F.Purification, characterization and immunological properties of 2,3-bisphosphoglycerate-independent phosphoglycerate mutase from maize (Zea mays) seedsEur. J. Biochem.186149-1531989Zea mays PubMed
3235Batke, J.; Nazaryan, K.B.; Karapetian, N.H.Complex of brain D-phosphoglycerate mutase and gamma enolase and its reactivation by D-glycerate 2,3-bisphosphateArch. Biochem. Biophys.264510-5181988Bos taurus PubMed
3236Castella, J.; Urena, J.; Ludevid, D.; Carreras, J.; Climent, F.Immunological properties of rat phosphoglycerate mutase isozymesBiochim. Biophys. Acta95697-1021988Rattus norvegicus PubMed
3237McAleese, S.M.; Dunbar, B.; Kay, I.; Fothergill-Gilmore, L.A.Cofactor-independent monophosphoglycerate mutaseBiochem. Soc. Trans.16558-5591988Neurospora crassa-
3238Johnson, C.M.; Price, N.C.Do metal ions promote the re-activation of the 2,3-bisphosphoglycerate-independent phosphoglycerate mutases?Biochem. J.252111-1171988Emericella nidulans, Neurospora crassa, Triticum aestivum PubMed
3239Johnson, C.M.; Gore, M.J.; Price, N.C.Co-factor-independent phosphoglycerate mutasesBiochem. Soc. Trans.158781987Bacillus megaterium, Bacillus subtilis, Cyberlindnera jadinii, Enterobacter aerogenes, Escherichia coli, Oryctolagus cuniculus, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Solanum tuberosum, Vigna radiata-
3240Johnson, C.M.; Price, N.C.How similar are the phosphoglycerate mutases from yeast and rabbit muscle?Biochem. Soc. Trans.15247-2481987Oryctolagus cuniculus, Saccharomyces cerevisiae-
3241Pawluk, A.; Scopes, R.K.; Griffiths-Smith, K.Isolation and properties of the glycolytic enzymes from Zymomonas mobilis. The five enzymes from glyceraldehyde-3-phosphate dehydrogenase through to pyruvate kinaseBiochem. J.238275-2811986Zymomonas mobilis PubMed
3242Prehu, C.; Prehu, M.O.; Kechemir, D.; Rosa, R.Purification of the M-type phosphoglyceromutase from rabbit muscleJ. Chromatogr.360203-2101986Oryctolagus cuniculus PubMed
3243Botha, F.C.; Dennis, D.T.Isozymes of phosphoglyceromutase from the developing endosperm of Ricinus communis: isolation and kinetic propertiesArch. Biochem. Biophys.24596-1031986Ricinus communis PubMed
3244Smith, G.C.; Hass, L.F.Wheat germ phosphoglycerate mutase: purification, polymorphism, and inhibitionBiochem. Biophys. Res. Commun.131743-7491985Triticum aestivum PubMed
3245Rosa, R.; Calvin, M.C.; Prehu, M.O.; Arous, N.Purification of human erythrocyte phosphoglyceromutaseJ. Chromatogr.285203-2091984Homo sapiens PubMed
3246Kulbe, K.D.; Foellmer, H.; Fuchs, J.Simultaneous purification of glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and phosphoglycerate mutase from pig liver and muscleMethods Enzymol.90498-5111982Sus scrofa PubMed
3247Scopes, R.K.; Stoter, A.Purification of all glycolytic enzymes from one muscle extractMethods Enzymol.90479-4901982Oryctolagus cuniculus PubMed
3248Bartrons, R.; Carreras, J.Purification and characterization of phosphoglycerate mutase isozymes from pig heartBiochim. Biophys. Acta708167-1771982Sus scrofa PubMed
3249Singh, R.P.; Setlow, P.Purification and properties of phosphoglycerate phosphomutase from spores and cells of Bacillus megateriumJ. Bacteriol.1371024-10271979Bacillus megaterium, Bacillus subtilis PubMed
3250Watabe, K.; Freese, E.Purification and properties of the manganese-dependent phosphoglycerate mutase of Bacillus subtilisJ. Bacteriol.137773-7781979Bacillus subtilis PubMed
3251Ikura, K.; Narita, H.; Sasaki, R.; Chiba, H.Immunochemical and enzymatic properties of bisphosphoglyceromutase/phosphatase and phosphoglyceromutase from human erythrocytesEur. J. Biochem.8923-311978Homo sapiens PubMed
3252Gatehouse, J.A.; Knowles, J.R.Phosphoglycerate mutase from wheat germ. Studies with isotopically labeled 3-phospho-D-glycerates showing that the catalyzed reaction is intramolecularBiochemistry163045-30521977Triticum aestivum PubMed
3253Hill, B.; Attwood, M.M.Purification and characterization of phosphoglycerate mutase from methanol-grown Hyphomicrobium X and Pseudomonas AM1J. Gen. Microbiol.96185-1931976Hyphomicrobium sp., Pseudomonas sp. PubMed
3254Sheibley, R.H.; Hass, L.F.Isolation and partial characterization of monophosphoglycerate mutase from human erythrocytesJ. Biol. Chem.2516699-67041976Homo sapiens PubMed
3255Hass, L.F.; Sheibley, R.H.; Kappel, W.K.; Miller, K.B.A comparison of some of the physical and chemical properties of the phosphoglycerate mutases from human erythrocytesBiochem. Biophys. Res. Commun.72976-9831976Homo sapiens PubMed
3256Hartman, F.C.; Norton, I.L.Detection of an essential sulfhydryl group in phosphoglycerate mutase with an affinity-labeling reagentJ. Biol. Chem.2514565-45691976Oryctolagus cuniculus PubMed
3257Sasaki, R.; Utsumi, S.; Sugimoto, E.; Chiba, H.Subunit structure and multifunctional properties of yeast phosphoglyceromutaseEur. J. Biochem.66523-5331976Saccharomyces cerevisiae PubMed
3258Grisolia, S.; Carreras, J.Phosphoglycerate mutase from yeast, chicken breast muscle, and kidney (2,3-PGA-dependent)Methods Enzymol.42435-4501975Gallus gallus, Saccharomyces cerevisiae, Sus scrofa PubMed
3259Grisolia, S.; Carreras, J.Phosphoglycerate mutase from wheat germ (2,3-PGA-independent)Methods Enzymol.42429-4351975Oryza sativa, Triticum aestivum-
3260D'Alessio, G.; Josse, J.Phosphoglycerate kinase, phosphoglyceromutase from Escherichia coliMethods Enzymol.42139-1441975Escherichia coli PubMed
3261Sakoda, S.; Shanske, D.; DiMauro, S.; Schon, E.A.Isolation of a cDNA encoding the B isozyme of human phosphoglycerate mutase (PGAM) and characterization of the PGAM gene familyJ. Biol. Chem.26316899-169051988Homo sapiens PubMed
3262Shanske, S.; Sakoda, S.; Hermodson, M.A.; DiMauro, S.; Schon, E.A.Isolation of cDNA encoding the muscle-specific subunit of human phosphoglycerate mutaseJ. Biol. Chem.26214612-146171987Homo sapiens PubMed
649101Crowhurst, G.S.; Dalby, A.R.; Isupov, M.N.; Campbell, J.W.; Littlechild, J.A.Structure of a phosphoglycerate mutase:3-phosphoglyceric acid complex at 1.7 AActa Crystallogr. Sect. D551822-18261999Saccharomyces cerevisiae PubMed
649202Poonperm, B.; Guerra, D.G.; McNae, I.W.; Fothergill-Gilmore, L.A.; Walkinshaw, M.D.Expression, purification, crystallization and preliminary crystallographic analysis of Leishmania mexicana phosphoglycerate mutaseActa Crystallogr. Sect. D591313-13162003Leishmania mexicana PubMed
649656Walter, R.A.; Nairn, J.; Duncan, D.; Price, N.C.; Kelly, S.M.; Rigden, D.J.; Fothergill-Gilmore, L.A.The role of the C-terminal region in phosphoglycerate mutaseBiochem. J.33789-951999Saccharomyces cerevisiae, Schizosaccharomyces pombe-
650753Chander, M.; Setlow, B.; Setlow, P.The enzymatic activity of phosphoglycerate mutase from gram-positive endospore-forming bacteria requires Mn2+ and is pH sensitiveCan. J. Microbiol.44759-7671998Bacillus subtilis, Clostridium perfringens, Micrococcus luteus, Planococcus citreus, Sporosarcina ureae, Staphylococcus saprophyticus, Streptomyces coelicolor PubMed
650970Jedrzejas, M.J.; Chander, M.; Setlow, P.; Krishnasamy, G.Structure and mechanism of action of a novel phosphoglycerate mutase from Bacillus stearothermophilusEMBO J.191419-14312000Geobacillus stearothermophilus PubMed
651058Chevalier, N.; Rigden, D.J.; Van Roy, J.; Opperdoes, F.R.; Michels, P.A.Trypanosoma brucei contains a 2,3-bisphosphoglycerate independent phosphoglycerate mutaseEur. J. Biochem.2671464-14722000Trypanosoma brucei PubMed
651088Nairn, J.; Duncan, D.; Price, N.E.; Kelly, S.M.; Fothergill-Gilmore, L.A.; Uhrinova, S.; Barlow, P.N.; Rigden, D.J.; Price, N.C.Characterization of active-site mutants of Schizosaccharomyces pombe phosphoglycerate mutase. Elucidation of the roles of amino acids involved in substrate binding and catalysisEur. J. Biochem.2677065-70742000Schizosaccharomyces pombe PubMed
651372van der Oost, J.; Huynen, M.A.; Verhees, C.H.Molecular characterization of phosphoglycerate mutase in archaeaFEMS Microbiol. Lett.212111-1202002Methanocaldococcus jannaschii, Pyrococcus furiosus PubMed
651716Potters, M.B.; Solow, B.T.; Bischoff, K.M.; Graham, D.E.; Lower, B.H.; Helm, R.; Kennelly, P.J.Phosphoprotein with phosphoglycerate mutase activity from the archaeon Sulfolobus solfataricusJ. Bacteriol.1852112-21212003Sulfolobus solfataricus PubMed
652790Rigden, D.J.; Walter, R.A.; Phillips, S.E.; Fothergill-Gilmore, L.A.Sulphate ions observed in the 2.12 A structure of a new crystal form of S. cerevisiae phosphoglycerate mutase provide insights into understanding the catalytic mechanismJ. Mol. Biol.2861507-15171999Saccharomyces cerevisiae PubMed
652799Rigden, D.J.; Walter, R.A.; Phillips, S.E.; Fothergill-Gilmore, L.A.Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysisJ. Mol. Biol.289691-6991999Saccharomyces cerevisiae, Schizosaccharomyces pombe PubMed
652846Uhrinova, S.; Uhrin, D.; Nairn, J.; Price, N.C.; Fothergill-Gilmore, L.A.; Barlow, P.N.Solution structure and dynamics of an open beta-sheet, glycolytic enzyme, monomeric 23.7 kDa phosphoglycerate mutase from Schizosaccharomyces pombeJ. Mol. Biol.306275-2902001Schizosaccharomyces pombe PubMed
652877Bond, C.S.; White, M.F.; Hunter, W.N.Mechanistic implications for Escherichia coli cofactor-dependent phosphoglycerate mutase based on the high-resolution crystal structure of a vanadate complexJ. Mol. Biol.3161071-10812002Escherichia coli PubMed
652915Rigden, D.J.; Lamani, E.; Mello, L.V.; Littlejohn, J.E.; Jedrzejas, M.J.Insights into the catalytic mechanism of cofactor-independent phosphoglycerate mutase from X-ray crystallography, simulated dynamics and molecular modelingJ. Mol. Biol.328909-9202003Geobacillus stearothermophilus PubMed
653052Chander, M.; Setlow, P.; Lamani, E.; Jedrzejas, M.J.Structural studies on a 2,3-diphosphoglycerate independent phosphoglycerate mutase from Bacillus stearothermophilusJ. Struct. Biol.126156-1651999Geobacillus stearothermophilus PubMed
660610Muller, P.; Sawaya, M.R.; Pashkov, I.; Chan, S.; Nguyen, C.; Wu, Y.; Perry, L.J.; Eisenberg, D.The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutaseActa Crystallogr. Sect. D61309-3152005Mycobacterium tuberculosis PubMed
660633Watkins, H.A.; Yu, M.; Baker, E.N.Cloning, expression, purification and preliminary crystallographic data for Rv3214 (EntD), a predicted cofactor-dependent phosphoglycerate mutase from Mycobacterium tuberculosisActa Crystallogr. Sect. FF61753-7552005Mycobacterium tuberculosis PubMed
660903Wang, Y.; Wei, Z.; Liu, L.; Cheng, Z.; Lin, Y.; Ji, F.; Gong, W.Crystal structure of human B-type phosphoglycerate mutase bound with citrateBiochem. Biophys. Res. Commun.3311207-12152005Homo sapiens PubMed
661261de Atauri, P.; Repiso, A.; Oliva, B.; Vives-Corrons, J.L.; Climent, F.; Carreras, J.Characterization of the first described mutation of human red blood cell phosphoglycerate mutaseBiochim. Biophys. Acta1740403-4102005Homo sapiens PubMed
661634Guerra, D.G.; Vertommen, D.; Fothergill-Gilmore, L.A.; Opperdoes, F.R.; Michels, P.A.Characterization of the cofactor-independent phosphoglycerate mutase from Leishmania mexicana mexicana. Histidines that coordinate the two metal ions in the active site show different susceptibilities to irreversible chemical modificationEur. J. Biochem.2711798-18102004Leishmania mexicana PubMed
661689Saavedra, E.; Encalada, R.; Pineda, E.; Jasso-Chavez, R.; Moreno-Sanchez, R.Glycolysis in Entamoeba histolytica. Biochemical characterization of recombinant glycolytic enzymes and flux control analysisFEBS J.2721767-17832005Entamoeba histolytica PubMed
661847Repiso, A.; Ramirez Bajo, M.J.; Corrons, J.L.; Carreras, J.; Climent, F.Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studiesHaematologica90257-2592005Homo sapiens PubMed
661851Gonzalez-Cinca, N.; Perez de la Ossa, P.; Carreras, J.; Climent, F.Effects of thyroid hormone and hypoxia on 2,3-bisphosphoglycerate, bisphosphoglycerate synthase and phosphoglycerate mutase in rabbit erythroblasts and reticulocytes in vivoHorm. Res.62191-1962004Oryctolagus cuniculus PubMed
662259Zhang, Y.; Foster, J.M.; Kumar, S.; Fougere, M.; Carlow, C.K.Cofactor-independent phosphoglycerate mutase has an essential role in Caenorhabditis elegans and is conserved in parasitic nematodesJ. Biol. Chem.27937185-371902004Brugia malayi, Caenorhabditis elegans PubMed
677357Lokanath, N.K.; Kunishima, N.Purification, crystallization and preliminary X-ray crystallographic analysis of the archaeal phosphoglycerate mutase PH0037 from Pyrococcus horikoshii OT3Acta Crystallogr. Sect. F62788-7902006Pyrococcus horikoshii PubMed
677393Kleinman, H.; Ford, B.; Keller, J.; Carpino, N.; Nassar, N.Crystallization and initial crystal characterization of the C-terminal phosphoglycerate mutase homology domain of Sts-1Acta Crystallogr. Sect. FF62218-2202006Mus musculus PubMed
677798Kuhn, N.J.; Setlow, B.; Setlow, P.Manganese(II) activation of 3-phosphoglycerate mutase of Bacillus megaterium: pH-sensitive interconversion of active and inactive formsArch. Biochem. Biophys.306342-3491993Bacillus megaterium PubMed
678734Nukui, M.; Mello, L.V.; Littlejohn, J.E.; Setlow, B.; Setlow, P.; Kim, K.; Leighton, T.; Jedrzejas, M.J.Structure and molecular mechanism of Bacillus anthracis cofactor-independent phosphoglycerate mutase: a crucial enzyme for spores and growing cells of Bacillus speciesBiophys. J.92977-9882007Bacillus anthracis PubMed
679715Johnsen, U.; Schoenheit, P.Characterization of cofactor-dependent and cofactor-independent phosphoglycerate mutases from ArchaeaExtremophiles11647-6572007Archaeoglobus fulgidus, Thermoplasma acidophilum PubMed
680944Hakobyan, D.; Nazaryan, K.Investigation of interaction between enolase and phosphoglycerate mutase using molecular dynamics simulationJ. Biomol. Struct. Dyn.23625-6332006Saccharomyces cerevisiae PubMed
681851Evans, M.J.; Morris, G.M.; Wu, J.; Olson, A.J.; Sorensen, E.J.; Cravatt, B.F.Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxidesMol. Biosyst.3495-5062007Homo sapiens PubMed
682237Djikeng, A.; Raverdy, S.; Foster, J.; Bartholomeu, D.; Zhang, Y.; El-Sayed, N.M.; Carlow, C.Cofactor-independent phosphoglycerate mutase is an essential gene in procyclic form Trypanosoma bruceiParasitol. Res.100887-8922007Trypanosoma brucei PubMed
690732Kajiwara, K.; Sunaga, K.; Tsuda, T.; Sugaya, A.; Sugaya, E.; Kimura, M.Peony root extract upregulates transthyretin and phosphoglycerate mutase in mouse cobalt focus seizureBiochem. Biophys. Res. Commun.371375-3792008Mus musculus PubMed
692403Saavedra, E.; Ramos-Casillas, L.E.; Marin-Hernandez, A.; Moreno-Sanchez, R.; Guerra-Sanchez, G.Glycolysis in Ustilago maydisFEMS Yeast Res.81313-13232008Ustilago maydis PubMed
693442Qiu, H.; Zhao, S.; Xu, X.; Yerle, M.; Liu, B.Assignment and expression patterns of porcine muscle-specific isoform of phosphoglycerate mutase geneJ. Genet. Genomics35257-2602008Sus scrofa PubMed
694050Jacobowitz, D.M.; Jozwik, C.; Fukuda, T.; Pollard, H.B.Immunohistochemical localization of phosphoglycerate mutase in capillary endothelium of the brain and peripheryMicrovasc. Res.7689-932008Rattus norvegicus PubMed
694538Foster, J.M.; Raverdy, S.; Ganatra, M.B.; Colussi, P.A.; Taron, C.H.; Carlow, C.K.The Wolbachia endosymbiont of Brugia malayi has an active phosphoglycerate mutase: a candidate target for anti-filarial therapiesParasitol. Res.1041047-10522009Wolbachia sp. PubMed
703707Kowalski, W.; Gizak, A.; Rakus, D.Phosphoglycerate mutase in mammalian striated muscles: subcellular localization and binding partnersFEBS Lett.5831841-18452009Oryctolagus cuniculus, Rattus norvegicus PubMed
703862iao, Y.; Jin, X.; Yan, J.; Jiao, F.; Li, X.; Roe, B.A.; Jarrett, H.W.; Gu, W.An insertion of intracisternal A-particle retrotransposon in a novel member of the phosphoglycerate mutase family in the lew allele of mutant miceGenes Genet. Syst.84327-3342009Mus musculus PubMed
705169Nowicki, M.W.; Kuaprasert, B.; McNae, I.W.; Morgan, H.P.; Harding, M.M.; Michels, P.A.; Fothergill-Gilmore, L.A.; Walkinshaw, M.D.Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclassJ. Mol. Biol.394535-5432009Leishmania mexicana PubMed
705270Kimura, A.; Sakurai, T.; Koumura, A.; Yamada, M.; Hayashi, Y.; Tanaka, Y.; Hozumi, I.; Tanaka, R.; Takemura, M.; Seishima, M.; Inuzuka, T.High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseasesJ. Neuroimmunol.219105-1082010Rattus norvegicus PubMed
705672Ren, F.; Wu, H.; Lei, Y.; Zhang, H.; Liu, R.; Zhao, Y.; Chen, X.; Zeng, D.; Tong, A.; Chen, L.; Wei, Y.; Huang, C.Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinomaMol. Cancer9812010Homo sapiens PubMed
706661Hakobyan, D.; Nazaryan, K.Molecular dynamics study of interaction and substrate channeling between neuron-specific enolase and B-type phosphoglycerate mutaseProteins781691-17042010Homo sapiens PubMed
715964Solem, C.; Petranovic, D.; Koebmann, B.; Mijakovic, I.; Jensen, P.R.Phosphoglycerate mutase is a highly efficient enzyme without flux control in Lactococcus lactisJ. Mol. Microbiol. Biotechnol.18174-1802010Lactococcus lactis subsp. lactis PubMed
716984Li, Z.; Galvin, B.D.; Raverdy, S.; Carlow, C.K.Identification and characterization of the cofactor-independent phosphoglycerate mutases of Dirofilaria immitis and its Wolbachia endosymbiontVet. Parasitol.176350-3562011Dirofilaria immitis, Wolbachia sp. PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 5.4.2.1)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)