Information on EC 5.2.1.8 - Peptidylprolyl isomerase:

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EC NUMBERCOMMENTARY
5.2.1.8-

RECOMMENDED NAMEGeneOntology No.
Peptidylprolyl isomeraseGO:0042027

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
peptidylproline (omega=180) = peptidylproline (omega=0)
show the reaction diagram
----
peptidylproline (omega=180) = peptidylproline (omega=0)
show the reaction diagram
covalent mechanism which involves an approximately tetravalent carbon of the prolyl imidic bond for the transition state of reactionSus scrofa-2512
peptidylproline (omega=180) = peptidylproline (omega=0)
show the reaction diagram
the refolding mechanism is similar in the presence and absence of the enzymeEscherichia coli-2513
peptidylproline (omega=180) = peptidylproline (omega=0)
show the reaction diagram
mechanism that involves distortion of bound substrate with a twisted, 90° , peptidyl-propyl amide bondHomo sapiens-2539

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
cis-trans-isomerizationTrypanosoma cruziB8XP93-714320
cis-trans-isomerizationHomo sapiens, Mus musculus--715609
cis-trans-isomerizationEscherichia coli--715653
rotation--single bond-

PATHWAYKEGG LinkMetaCyc Link
No entries in this field

SYSTEMATIC NAMEIUBMB Comments
Peptidylproline cis-trans-isomeraseThe first type of this enzyme found [1] proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
12 kDa FKBP----
12.6 kDa FKBP----
13 kDa FKBP----
15 kDa FKBP----
19 kDa FK506-binding protein----
22 kDa FK506-binding protein----
25 kDa FKBP----
27 kDa membrane protein----
36 kDa FK506 binding protein----
40 kDa thylakoid lumen PPIase----
40 kDa thylakoid lumen rotamase----
51 kDa FK506-binding protein----
52 kDa FK506 binding protein----
54 kDa progesterone receptor-associated immunophilin----
65 kDa FK506-binding protein----
CeCYP-16Caenorhabditis elegansQ7KFC0-652239
CGI-124----
Chl-Mip----
Cj0596Campylobacter jejuni--702908
CPH----
Cyclophilin----
CyclophilinBacillus subtilis--649837
CyclophilinSaccharomyces cerevisiae--653218
CyclophilinHomo sapiens--653822
CyclophilinHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9-716659
Cyclophilin 18----
cyclophilin 3Caenorhabditis elegans--651964
Cyclophilin 33----
Cyclophilin A----
Cyclophilin ASaccharomyces cerevisiae--650973
Cyclophilin ABos taurus--651755
Cyclophilin AHomo sapiens--653685, 704474, 705430
Cyclophilin B----
Cyclophilin BHomo sapiens--653828, 704474
Cyclophilin C----
Cyclophilin cyp2----
cyclophilin HHomo sapiens--652921
cyclophilin hCyp-18Homo sapiens--651287
Cyclophilin homolog----
cyclophilin JHomo sapiens--660614
Cyclophilin ScCypA----
Cyclophilin ScCypB----
Cyclophilin-10----
Cyclophilin-11----
Cyclophilin-40----
Cyclophilin-60----
cyclophilin-AOryctolagus cuniculus--662319
cyclophilin-DRattus norvegicus--660983
Cyclophilin-like protein Cyp-60----
Cyclophilin-related protein----
Cyclosporin A-binding protein----
CypArabidopsis thalianaP34790, P34791-651848
CYP-3Caenorhabditis elegans--651964
CYP-40----
CYP-5Caenorhabditis elegansP52014-652894
CYP-6Caenorhabditis elegansP52014-652894
cyp-AOryctolagus cuniculus--662319
CYP-S1----
Cyp1Oryza sativaQ40672, Q40673-653484
Cyp18Homo sapiens--653822
Cyp2Oryza sativaQ40672, Q40673-653484
CYP20-2Arabidopsis thalianaQ9SCY2i.e. cyclophilin 20-2706176
CYP20-3Arabidopsis thalianaP34791-678048
CYP20-3Arabidopsis thalianaQ9SCY2i.e. cyclophilin 20-3706176
Cyp3 PPIase----
Cyp40Homo sapiens--652854
CyPA----
CyPAHomo sapiens--704474, 705430
CyPB----
CyPBHomo sapiens--653828, 704474
CyPJHomo sapiens--660614
Estrogen receptor binding cyclophilin----
FF1 antigen----
FKBP----
FKBP-12----
FKBP-12.6----
FKBP-13----
FKBP-15----
FKBP-19----
FKBP-21----
FKBP-22----
FKBP-23----
FKBP-25----
FKBP-36----
FKBP-51----
FKBP-70----
FKBP12Rattus norvegicus, Xenopus laevisO42123-705910
FKBP13Arabidopsis thalianaQ9SCY2i.e. FK506-binding protein 13706176
FKBP1BXenopus laevis--714800
FKBP22----
FKBP35Plasmodium falciparum--662803
FKBP38Homo sapiensQ14318-681919
FKBP51Homo sapiens--652854
FKBP52Homo sapiens--652854
FKBP52Rattus norvegicus, Xenopus laevisO42123-705910
FKBP52 protein----
FKBP54----
FKBP59----
FKBP65----
FKBP65RS----
FKBP77Triticum aestivum--653500
FkpAEscherichia coli--652932, 662045, 715653
FkpASalmonella enterica subsp. enterica serovar Typhimurium--701755
h Par14Homo sapiens--652918
HBI----
HcCYPHaemonchus contortusQ4G338-663015
hCyP33Homo sapiens--660910
Histidine rich protein----
hPar14----
hPar14Homo sapiens--652844
hPin1Homo sapiens--652417
HSP binding immunophilin----
HSP90-binding immunophilin----
Immunophilin FKBP12----
Immunophilin FKBP12.6----
Immunophilin FKBP36----
Immunophilin FKBP65----
Isomerase, peptidylprolyl cis-trans----
L.p.Cyp18Legionella pneumophila--2527
Macrolide binding protein----
Macrophage infectivity potentiator----
mimicypAcanthamoeba polyphaga MimivirusQ5UP71-693639
MtFK----
MtFKMethanothermococcus thermolithotrophicusO52980-2525
MtFKBP17Methanothermococcus thermolithotrophicus--652911
mzFKBP-66Zea mays--653563
Ng-MIPNeisseria gonorrhoeae--662909
Nucleolar proline isomerase----
OvCYP-16Onchocerca volvulusQ8IA80-652239
p17.7----
P31----
P54----
p59 protein----
Par10Escherichia coliP0A9L5-663328
Par14----
Par14Homo sapiens, Mus musculus--705715
Par27Bordetella pertussis--693627, 705408
Par45Trypanosoma cruziB8XP93-714320
Parvulin----
ParvulinEscherichia coli--649847
ParvulinHomo sapiens, Mus musculus--705715
Parvulin 14----
parvulin-like proteinRickettsia prowazekiiQ9ZCX6-661913
parvulin1 4Homo sapiens--652918
pCYP BVicia faba--653459
Peptide bond isomerase----
peptidyl prolyl cis-trans isomeraseCampylobacter jejuni--702908
peptidyl prolyl isomerase-like protein 1Homo sapiensQ9Y3C6-680652
Peptidyl-prolyl cis-trans isomerase----
Peptidyl-prolyl cis-trans isomeraseSus scrofa--653787
Peptidyl-prolyl cis-trans isomeraseHomo sapiens--705715, 716069
Peptidyl-prolyl cis-trans isomeraseMus musculus--705715
Peptidyl-prolyl cis-trans isomeraseXenopus laevis--714800
Peptidyl-prolyl cis-trans isomeraseBacillus subtilis--716254
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens--716069
Peptidyl-prolyl cis-trans isomerase plp----
Peptidyl-prolyl cis-trans isomerase surA----
peptidyl-prolyl cis/trans isomeraseHomo sapiens--704474, 706012
peptidyl-prolyl cis/trans isomeraseArabidopsis thaliana--705728
peptidyl-prolyl cis/trans isomeraseTrypanosoma cruziB8XP93-714320
Peptidyl-prolyl cis/trans isomerase EPVH----
peptidyl-prolyl cis/trans isomerase NIMA-interacting 1Homo sapiens, Mus musculus--715609
peptidyl-prolyl isomeraseSalmonella enterica subsp. enterica serovar Typhimurium--701755
peptidyl-prolyl isomeraseHomo sapiens--703021, 703024, 704154, 705854, 715524, 715712
peptidyl-prolyl isomeraseRattus norvegicus--704154, 705910
peptidyl-prolyl isomeraseMus musculus--704931
peptidyl-prolyl isomeraseBordetella pertussis--705408
peptidyl-prolyl isomeraseXenopus laevisO42123-705910
peptidyl-prolyl isomeraseArabidopsis thalianaQ9SCY2-706176
peptidyl-prolyl isomeraseHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9-716659
peptidyl-prolyl isomeraseEscherichia coli--716907
peptidyl-prolyl isomerase 1Homo sapiens, Rattus norvegicus--705286
peptidylproline cis-trans-isomeraseHomo sapiens--705427
peptidylprolyl cis,trans-isomerasePisum sativum--651842
Peptidylprolyl cis-trans isomerase----
peptidylprolyl isomeraseBombyx moriB2LU30-701596
peptidylprolyl isomeraseHomo sapiens--705066, 715863
PfCyP----
Pin1Homo sapiens--650106, 652866, 703021, 703024, 705066, 705286, 705427, 705854, 706012, 715524, 715609, 715712, 715863, 716069
Pin1Mus musculus--650816, 704931, 715609
Pin1Homo sapiens, Rattus norvegicus-i.e. protein interacting with NIMA704154
Pin1Rattus norvegicus--705286
Pin1Arabidopsis thaliana--705728
PIN1-type parvulin 1Arabidopsis thaliana--705728
PIN1AtArabidopsis thaliana--652891
Planta-induced rust protein 28----
PlpRickettsia prowazekiiQ9ZCX6-661913
PP2A phosphatase activatorOryctolagus cuniculus--662459
PpiAMycobacterium tuberculosisP65762-661643
PpiAHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9peptidyl-prolyl isomerase domain716659
PPIase----
PPIaseMus musculus--650816, 705715
PPIasePisum sativum--651842
PPIaseBombyx moriB2LU30-701596
PPIaseHomo sapiens--704154, 704474, 705066, 705715, 715712, 715863, 716069
PPIaseRattus norvegicus--704154, 705910
PPIaseBordetella pertussis--705408
PPIaseXenopus laevisO42123-705910
PPIaseArabidopsis thalianaQ9SCY2-706176
PPIaseTrypanosoma cruziB8XP93-714320
PPIaseEscherichia coli--715653
PPIaseBacillus subtilis--716254
PPIaseHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9-716659
PPIase Pin1----
PPIase Pin4----
PpiBLegionella pneumophila--690528
PpiBBombyx moriB2LU30-701596
PpiBHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9peptidyl-prolyl isomerase domain716659
PPICHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9peptidyl-prolyl isomerase domain716659
PpiDEscherichia coli--662045
PpiDHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9peptidyl-prolyl isomerase domain716659
PPIEHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9peptidyl-prolyl isomerase domain716659
PPIFHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9peptidyl-prolyl isomerase domain716659
PPIGHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9peptidyl-prolyl isomerase domain716659
PPIHHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9peptidyl-prolyl isomerase domain716659
PPIL1Homo sapiens--679270
PPWD1Homo sapiensQ96BP3-692291
Proline rotamase----
prolyl cis-trans isomeraseEscherichia coli--715653
prolyl-peptidyl isomeraseHomo sapiens--705430
protein phosphatase 2A phosphatase activatorHomo sapiens--662459
Proteins, cyclophilins----
Proteins, specific or class, cyclophilins----
PrsABacillus subtilis--716254
Ptf1/Ess1Saccharomyces cerevisiae--649847
PtpAHomo sapiens, Oryctolagus cuniculus--662459
Rapamycin-binding protein----
Rapamycin-selective 25 kDa immunophilin----
Rotamase----
RotamaseArabidopsis thalianaP34790, P34791-651848
RotamaseZea mays--653563
Rotamase Pin1----
Rotamase Pin4----
Rotamase plp----
S-cyclophilin----
S1205-06----
SCYLP----
SDCCAG-10Homo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9; peptidyl-prolyl isomerase domain716659
sFkpAEscherichia coli--678149
SlrAStreptococcus pneumoniae--662464
SLyDEscherichia coli--716907
SmCYP A----
SmCYP B----
Smp17.7----
SP18----
SurAEscherichia coli--662045
SurASalmonella enterica subsp. enterica serovar Typhimurium--701755
TcFKBP18Thermococcus sp.--649714
TFEscherichia coli--652525
TLP20Spinacia oleraceaP82536-651323
trigger factorBacillus subtilis--649837
trigger factorMycoplasma genitalium--651071, 652779
trigger factorEscherichia coli--652525
WHP----
YpaSaccharomyces cerevisiae--662459
MIPLegionella pneumophila--680130
additional informationBombyx moriB2LU30PPIB contains conserved and unique cyclophilin domain and belongs to cyclophilin superfamily701596
additional informationHomo sapiens, Rattus norvegicus-the enzyme belongs to the parvulin family of PPIases704154
additional informationHomo sapiens-the enzyme belongs to the CyP family of proteins705430
additional informationRattus norvegicus, Xenopus laevisO42123the enzyme is a member of the FKBP family705910

CAS REGISTRY NUMBERCOMMENTARY
95076-93-0-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Acanthamoeba polyphaga Mimivirus-693639Q5UP71UniProtManually annotated by BRENDA team
Arabidopsis thaliana-652891, 679826, 705728--Manually annotated by BRENDA team
Arabidopsis thalianacyclophilin CYP20-3678048P34791SwissProtManually annotated by BRENDA team
Arabidopsis thalianaFKBP13706176Q9SCY2UniProtManually annotated by BRENDA team
Arabidopsis thalianaROC1, cytosolic enzyme; two genes encoding CypP: ROC1 and ROC4651848P34790SwissprotManually annotated by BRENDA team
Arabidopsis thalianaROC4, chloroplastic enzyme; two genes encoding CypP: ROC1 and ROC4651848P34791SwissProtManually annotated by BRENDA team
Bacillus subtilis-649837, 716254--Manually annotated by BRENDA team
Bacillus subtilis IH8478-716254--Manually annotated by BRENDA team
Bombyx morigene PPIB701596B2LU30UniProtManually annotated by BRENDA team
Bordetella pertussis-705408--Manually annotated by BRENDA team
Bordetella pertussisPar27 belongs to parvulin family693627P40415UniProtManually annotated by BRENDA team
Bos taurus-2516, 2520, 2536, 2549, 651755--Manually annotated by BRENDA team
Brassica napus-653605--Manually annotated by BRENDA team
Caenorhabditis elegans-651964--Manually annotated by BRENDA team
Caenorhabditis elegans-652239Q7KFC0SwissProtManually annotated by BRENDA team
Caenorhabditis elegansthe organism expressed 18 cyclophilin isoforms, eight of which are conserved single domain forms, comprising two closely related secreted or type B forms, CYP-5 and CYP-6652894P52014UniprotManually annotated by BRENDA team
Campylobacter jejunistrain 81-176, gene cj0596702908--Manually annotated by BRENDA team
Campylobacter jejuni 81-176strain 81-176, gene cj0596702908--Manually annotated by BRENDA team
Chlamys farrericyclophilin A694097Q6USC1UniProtManually annotated by BRENDA team
Cricetulus griseus-652182--Manually annotated by BRENDA team
Erwinia chrysanthemi-2551--Manually annotated by BRENDA team
Escherichia coli-2533, 2538, 649847, 652525, 652727, 715653, 716907--Manually annotated by BRENDA team
Escherichia coli-652932, 678149P45523UniprotManually annotated by BRENDA team
Escherichia coli2 distinct forms of peptidylprolyl-cis-trans-isomerase are expressed separately in periplasmic and cytoplasmic compartments2554--Manually annotated by BRENDA team
Escherichia coliisoform Par10663328P0A9L5SwissprotManually annotated by BRENDA team
Escherichia coliisoform PpiD692303--Manually annotated by BRENDA team
Escherichia coliisoform SlyD680509--Manually annotated by BRENDA team
Escherichia coliisoforms FkpA, PpiA, PpiD, SurA662045--Manually annotated by BRENDA team
Escherichia colistrain B2513--Manually annotated by BRENDA team
Escherichia coli AB2847-715653--Manually annotated by BRENDA team
Escherichia coli B/E1-716907--Manually annotated by BRENDA team
Gallus gallus-2522--Manually annotated by BRENDA team
Geobacillus stearothermophilus-2550--Manually annotated by BRENDA team
Haemaphysalis longicornisisoform cyclophilin A694932B2ZWT4UniProtManually annotated by BRENDA team
Haemaphysalis longicornisisoform cyclophilin B694932B2ZWT5UniProtManually annotated by BRENDA team
Haemonchus contortus-663015Q4G338SwissprotManually annotated by BRENDA team
Homo sapiens-2516, 2518, 2519, 2523, 2527, 2529, 2530, 2531, 2539, 2540, 2542, 2543, 2545, 2546, 2547, 2548, 649847, 650106, 651287, 652854, 652866, 652918, 652921, 653685, 653822, 653828, 660614, 661761, 662459, 678713, 678717, 681273, 681281, 691625, 694818, 703021, 703024, 704154, 704474, 705066, 705286, 705427, 705430, 705715, 705854, 706012, 715524, 715609, 715712, 715863, 716069--Manually annotated by BRENDA team
Homo sapiens-2541, 716659P62937UniProtManually annotated by BRENDA team
Homo sapiens-652417, 652844, 680060Q13526SwissProtManually annotated by BRENDA team
Homo sapiens-716659O43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9UniProtManually annotated by BRENDA team
Homo sapiens; isoform cyclophilin J660626Q9H2H8SwissprotManually annotated by BRENDA team
Homo sapienscyclophilin A661082P62937UniProtManually annotated by BRENDA team
Homo sapienscyclophilin B, is critical for the efficient replication of the hepatitis C virus genome662835--Manually annotated by BRENDA team
Homo sapiensisoform cyclophilin A691452--Manually annotated by BRENDA team
Homo sapiensisoform cyclophilin B693077--Manually annotated by BRENDA team
Homo sapiensisoform cyclophilin Cyp-18681274--Manually annotated by BRENDA team
Homo sapiensisoform cyclophorin A681275--Manually annotated by BRENDA team
Homo sapiensisoform CypA is necessary for the prolactin-induced activation of Janus-activated kinase 2 and the progression of human breast cancer691626--Manually annotated by BRENDA team
Homo sapiensisoform FKBP678742--Manually annotated by BRENDA team
Homo sapiensisoform FKBP12678627, 678714, 678715, 678716, 680340, 682235--Manually annotated by BRENDA team
Homo sapiensisoform FKBP12678718P62942UniprotManually annotated by BRENDA team
Homo sapiensisoform FKBP12, recombinant protein681701--Manually annotated by BRENDA team
Homo sapiensisoform FKBP38681919Q14318UniprotManually annotated by BRENDA team
Homo sapiensisoform Pin1678442, 680662, 681198, 681404, 693136Q13526SwissProtManually annotated by BRENDA team
Homo sapiensisoform Pin1690722, 690907, 694290--Manually annotated by BRENDA team
Homo sapiensisoform Pin1, recombinant enzyme662861--Manually annotated by BRENDA team
Homo sapiensisoform PPIL1679270--Manually annotated by BRENDA team
Homo sapiensisoform PPIL1680652Q9Y3C6UniprotManually annotated by BRENDA team
Homo sapienspeptidylprolyl isomerase containing WD40 repeat692291Q96BP3UniprotManually annotated by BRENDA team
Homo sapiensrecombinant protein, expressed in Escherichia coli660910--Manually annotated by BRENDA team
Homo sapienswild-type and mutant enzymes W121A, H54Q, R55A, F60A, Q111A, F133A, and H126Q2596--Manually annotated by BRENDA team
Legionella pneumophila-2527, 690528--Manually annotated by BRENDA team
Legionella pneumophilaisoform Mip, FK506-binding protein680130--Manually annotated by BRENDA team
Lupinus luteus-694993O49886UniProtManually annotated by BRENDA team
Methanothermococcus thermolithotrophicus-2525, 652911--Manually annotated by BRENDA team
Methanothermococcus thermolithotrophicusDSM20952525O52980SwissProtManually annotated by BRENDA team
Methanothermococcus thermolithotrophicus DSM2095DSM20952525O52980SwissProtManually annotated by BRENDA team
Mus musculus-2544, 650816, 662319, 705715, 715609--Manually annotated by BRENDA team
Mus musculusimmature female mice, isoform Pin1681633Q9QUR7SwissProtManually annotated by BRENDA team
Mus musculusmale C57BJ/6J mice704931--Manually annotated by BRENDA team
Mus musculuswild type and and isoform Pin1-/- mice679822--Manually annotated by BRENDA team
Mycobacterium tuberculosissoluble expression in Escherichia coli661643P65762SwissprotManually annotated by BRENDA team
Mycoplasma genitalium-651071, 652779--Manually annotated by BRENDA team
Neisseria gonorrhoeae-662909--Manually annotated by BRENDA team
Neurospora crassa-2514--Manually annotated by BRENDA team
Onchocerca volvulus-652239Q8IA80SwissProtManually annotated by BRENDA team
Oryctolagus cuniculus-662319--Manually annotated by BRENDA team
Oryctolagus cuniculusisoform cyclophilin A693250Q9TTC6UniprotManually annotated by BRENDA team
Oryctolagus cuniculusrecombinant wild-type enzyme and a His-tagged version662459--Manually annotated by BRENDA team
Oryza sativa-653484Q40673SwissProtManually annotated by BRENDA team
Oryza sativamRNA653484Q40672SwissProtManually annotated by BRENDA team
Pisum sativum-651842--Manually annotated by BRENDA team
Plasmodium falciparum-2534, 2555, 662803--Manually annotated by BRENDA team
Rattus norvegicus-2520, 2532, 2537, 660983, 693310, 704154--Manually annotated by BRENDA team
Rattus norvegicus-680665B0BNL2SwissProtManually annotated by BRENDA team
Rattus norvegicusFKBP12705910O42123UniProtManually annotated by BRENDA team
Rattus norvegicusSprague-Dawley rats705286--Manually annotated by BRENDA team
Ricinus communisisoform RcCyp1694779Q8VX73UniProtManually annotated by BRENDA team
Rickettsia prowazekiiGenBank661913Q9ZCX6SwissProtManually annotated by BRENDA team
Saccharomyces cerevisiae-2524, 2526, 2528, 649847, 650973, 653218--Manually annotated by BRENDA team
Saccharomyces cerevisiae3 molecular forms: PPI-I, PPI-II, and PPI-III2521--Manually annotated by BRENDA team
Saccharomyces cerevisiaeisoforms Ypa1, Ypa2; isoform Ypa1662459--Manually annotated by BRENDA team
Salmonella enterica subsp. enterica serovar Typhimuriumstrains C5 and SL1344, genes surA and fkpA. SurA can functionally compensate for the absence of FkpA, but when SurA is missing, or especially when both SurA and FkpA are missing, the ability of cells to survive or recover from prolonged periods of C-starvation is significantly impaired701755--Manually annotated by BRENDA team
Schistosoma mansonicyclophilin A680801Q26548SwissProtManually annotated by BRENDA team
Schistosoma mansonienzyme form SmCYP A and SmCYP B. SmCYP B is the major schistosomal enzyme form2552, 2553--Manually annotated by BRENDA team
Solanum lycopersicumcv. VF36653605--Manually annotated by BRENDA team
Sorghum bicolorstudy on enzyme activity in drought tolerant and drought susceptible cultivars. In drought tolerant cultivars, significant water stress increases leaf enzyme activity, whereas in drought-susceptible cultivar enzyme activity decreases in response to drought682273--Manually annotated by BRENDA team
Spinacia oleracea-651323P82536UniprotManually annotated by BRENDA team
Streptococcus pneumoniae-662464--Manually annotated by BRENDA team
Sus scrofa-2507, 2508, 2509, 2510, 2511, 2512, 2515, 2517, 653787--Manually annotated by BRENDA team
Thermococcus sp.KS-1649714--Manually annotated by BRENDA team
Triticum aestivumcv Atir653500--Manually annotated by BRENDA team
Trypanosoma cruzi-714320B8XP93UniProtManually annotated by BRENDA team
Trypanosoma cruziisoform PIN1, parvulin-type, present in both dividing and non-dividing forms681821Q2I5R9SwissProtManually annotated by BRENDA team
Vicia faba-653459--Manually annotated by BRENDA team
Xenopus laevis-714800--Manually annotated by BRENDA team
Xenopus laevisFKBP12705910O42123UniProtManually annotated by BRENDA team
Zea mays-2535, 653563, 653605--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
malfunctionHomo sapiens-Pin1 is deregulated in many tumors703024
malfunctionHomo sapiens, Rattus norvegicus-Pin1 plays a role in neurodegenerative disease such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, overview704154
malfunctionHomo sapiens-Pin1 blockade leads to Bax cleavage, mitochondrial translocation and caspase 9 and 3 activation, irrespective of the presence of cytokines, and Pin1 blockade accelerates eosinophil apoptosis705854
malfunctionXenopus laevis-knockdown of FKBP1B induces eye formation malfunction714800
malfunctionHomo sapiens-Pin1 depletion is linked to a dysfunction of uncoating of human immunodeficiency virus type 1715524
malfunctionMus musculus-Pin1 knock-out mice exhibit impaired insulin signaling with glucose intolerance. Pin1 knock-out mice are resistant to diet-induced obesity715609
malfunctionHomo sapiens-knockdown of Pin1 does not prevent CK2alpha phosphorylation715712
malfunctionHomo sapiens-silencing of Pin1 expression results in decrease of hepatitis C virus replication in both hepatitis C virus replicon cells and cell culture grown hepatitis C virus-infected cells716069
physiological functionBombyx moriB2LU30peptidylprolyl isomerases play essential roles in protein folding and are implicated in immune response and cell cycle control. Bombyx mori PPIases may be involved in anti-Bombyx mori nucleopolyhedrovirus response, mechanism, overview701596
physiological functionSalmonella enterica subsp. enterica serovar Typhimurium-SurA may function to repair, or prevent damage to, the outer membrane upon exposure to PmB and may consequently limit damage to the inner-membrane701755
physiological functionCampylobacter jejuni-Cj0596 plays a role in interaction with host cells. Cj0596 is a periplasmic peptidyl prolyl cis-trans isomerase involved in Campylobacter jejuni motility, invasion, and colonization702908
physiological functionHomo sapiens-Pin1 markedly enhances transformation in primary lymphocytes by the c-Rel protein and by viral Rel/NF-kappaB oncoprotein v-Rel, it enhances the nuclear translocation of the Rel proteins, overview703021
physiological functionHomo sapiens-the Pin1 is located in the midbody ring in HeLa cells and regulates cell cycle progression and cytokinesis through centrosome protein Cep55, which is an essential component of the midbody ring703024
physiological functionHomo sapiens-Pin1 is a peptidyl prolyl cis-trans isomerase that isomerizes phospho-serine/threonine-proline motifs of its target proteins, it functions in concert with proline directed kinases, such as cyclin-dependent protein kinases, extracellular signal-regulated kinases, and c-Jun N-terminal kinase, and with protein phosphatases, such as protein phosphatase 1A and 2B, in a wide range of cellular processes including cell division, DNA damage response, and gene transcription, and in susceptibilty to cancer and neurogenerative diseases, detailed overview. Pin1 modulates excitotoxic and oxidative stress induced by perkaryal phosphorylation of NF-H. Pin1 is involved in regulation of SMRT levels. Pin1 mediates the neural-specific apoptosis machinery. Pin1 plays a post-phosphorylation role in regulating protein function, mechanisms, overview704154
physiological functionRattus norvegicus-Pin1 is a peptidyl prolyl cis-trans isomerase that isomerizes phospho-serine/threonine-proline motifs of its target proteins, it functions in concert with proline directed kinases, such as cyclin-dependent protein kinases, extracellular signal-regulated kinases, and c-Jun N-terminal kinase, and with protein phosphatases, such as protein phosphatase 1A and 2B, in a wide range of cellular processes including cell division, DNA damage response, and gene transcription, and in susceptibility to cancer and neurogenerative diseases, detailed overview. Pin1 modulates excitotoxic and oxidative stress induced by perkaryal phosphorylation of NF-H. Pin1 mediates the neural-specific apoptosis machinery. Pin1 is involved in regulation of SMRT levels. Pin1 plays a post-phosphorylation role in regulating protein function, mechanisms, overview704154
physiological functionMus musculus-peptidyl-prolyl isomerase, Pin1, is a critical regulator of NF-kappaB activation facilitating NF-kappaB binding in hepatocytes and protects against hepatic ischemia/reperfusion injury. Pin1 is required for full production of MIP-2, but not for production of TNFalpha704931
physiological functionHomo sapiens-Pin1 regulates the function and/or stability of phosphoproteins by altering the conformation of specific pSer/pThr-Pro peptide bonds705066
physiological functionHomo sapiens-Pin1 recognizes and induces cis-trans isomerization of pSer/Thr-Pro bonds, conferring phosphorylationdependent conformational changes relevant for protein function. In cortical neurons, Pin1 modulates the topographic phosphorylation of the proline-directed Ser/Thr residues within the tail domain of NF proteins by inhibiting the dephosphorylation by PP2A. Inhibition of Pin1 inhibits okadaic acid-induced aberrant perikaryal phosphorylation of NF, and inhibition of Pin1 inhibits the okadaic acid- or Fos-induced neuronal apoptosis, signaling role of PP2A by Pin1, overview705286
physiological functionRattus norvegicus-Pin1 recognizes and induces cis-trans isomerization of pSer/Thr-Pro bonds, conferring phosphorylation-dependent conformational changes relevant for protein function. In cortical neurons, Pin1 modulates the topographic phosphorylation of the proline-directed Ser/Thr residues within the tail domain of NF proteins by inhibiting the dephosphorylation by PP2A. Inhibition of Pin1 inhibits okadaic acid-induced aberrant perikaryal phosphorylation of NF, and inhibition of Pin1 inhibits the okadaic acid- or Fos-induced neuronal apoptosis, signaling role of PP2A by Pin1, overview705286
physiological functionHomo sapiens-cyclophilin A is an essential cofactor for hepatitis C virus infection and the intracellular target of cyclosporine’s anti-HCV effect, mechanism by which CyPA facilitates HCV replication, overview705430
physiological functionArabidopsis thaliana-Arabidopsis thaliana PIN1-type parvulin 1, Pin1At, controls floral transition by accelerating cis/trans isomerization of the phosphorylated Ser/Thr-Pro motifs in two MADS-domain transcription factors, SOC1 and AGL24. The Ser/Thr-Pro motifs are important for Pin1At function in promoting flowering through AGL24 and SOC1. Phosphorylation-dependent prolyl cis/trans isomerization of key transcription factors is an important flowering regulatory mechanism, overview705728
physiological functionHomo sapiens-Pin1 is a key mediator of pro-survival signaling and a regulator of the pro-apoptotic Bcl-2-associated X protein, Bax, function. Pin1 likely functions as a downstream effector of GM-CSF and IL-5 signaling, and regulates cell death through the intrinsic, mitochondria- and caspase 9-dependent, apoptotic pathway, overview705854
physiological functionRattus norvegicus, Xenopus laevisO42123FKBP52 mediates stimulus-dependent TRPC1 gating through isomerization, which is required for chemotropic turning of neuronal growth cones to netrin-1 and myelin-associated glycoprotein and for netrin-1/DCC-dependent midline axon guidance of commissural interneurons in the developing spinal cord. By contrast, FKBP12 mediates spontaneous opening of TRPC1 through isomerization and is not required for growth cone responses to netrin-1, PPIase-dependent molecular mechanism, overview. PPIase-dependent regulation of netrin-1-induced Ca2+ influx by FKBP52. FKBP52 and its regulation of TRPC1 are essential for commissural axon guidance in vivo. The PPIase activity of FKBP52 is required for MAG-induced, but not for Sema3-induced, growth cone repulsion705910
physiological functionHomo sapiens-Pin1 is critical for the regulation of serine/threonine protein kinase B, PKB/Akt, stability and activation phosphorylation at S473 through the phosphorylated Thr-Pro motifs of Akt. Roles of Akt and Pin1 in oncogenesis, overview706012
physiological functionTrypanosoma cruziB8XP93Par45 is a phosphorylation-independent parvulin required for normal cell proliferation in a unicellular eukaryotic cell714320
physiological functionXenopus laevis-Xenopus peptidyl-prolyl cis-trans isomerase FKBP1B induces ectopic secondary axis and is involved in eye formation during Xenopus embryogenesis714800
physiological functionHomo sapiens-Pin1 prolyl isomerase activity is required for the disassembly of the human immunodeficiency virus type 1 core715524
physiological functionHomo sapiens, Mus musculus-Pin1 plays a critical role in adipose differentiation. Pin1 binds to IRS-1 and thereby markedly enhances insulin action, essential for adipogenesis715609
physiological functionEscherichia coli-colicin M unfolds during transfer across the outer or cytoplasmic membrane and refolds to the active form in the periplasm assisted by prolyl cis-trans isomerase/chaperone FkpA715653
physiological functionHomo sapiens-peptidyl-prolyl isomerase Pin1 is required for CK2alpha mitotic spindle localization. Pin1 protects CK2alpha from dephosphorylation in vivo715712
physiological functionHomo sapiens-Pin1 is a host factor for hepatitis C virus propagation and may contribute to hepatitis C virus-induced liver pathogenesis. Both binding and isomerase activities of Pin1 are essential for hepatitis C virus replication716069
physiological functionBacillus subtilis-PrsA catalyses the post-translocational folding of exported proteins and is essential for normal growth of Bacillus subtilis. PrsA is involved in the biosynthesis of the cylindrical lateral wall. PrsA is required for the folding of penicillin-binding protein 2a716254
physiological functionEscherichia coli-peptidyl-prolyl isomerase SLyD controls the recombinant folding of bacteriophage T4 long tail fiber fragments716907
malfunctionBacillus subtilis-Bacillus subtilis cells depleted of the PrsA protein are able to grow in the presence of a high concentration of magnesium (20 mM). PrsA depletion destabilizes penicillin-binding proteins716254
additional informationSalmonella enterica subsp. enterica serovar Typhimurium-SurA and FkpA are not involved in the starvation-stress response, SSR. Genes surA and fkpA appear to be dispensable for the cross-resistance of carbon-starved cells to oxidative stress701755

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate
LITERATURE/
Substrate
COMMENTARY/
Product
LITERATURE/
Product
Reversibility
r=reversible
ir=irreversible
?=not specified
(trans)-Pro190 of protein phosphatase 2A(cis)-Pro190 of protein phosphatase 2A
show the reaction diagram
Homo sapiens, Saccharomyces cerevisiae--662459--?
4-aminobenzoyl-Cys-Lys-(trans)-Pro-Ala-Cys-(NO2)-Tyr-NH24-aminobenzoyl-Cys-Lys-(cis)-Pro-Ala-Cys-(NO2)-Tyr-NH2
show the reaction diagram
Escherichia coli--715653--?
4-aminobenzoyl-Cys-Lys-(trans)-Pro-Gly-Cys-(NO2)-Tyr-NH24-aminobenzoyl-Cys-Lys-(cis)-Pro-Gly-Cys-(NO2)-Tyr-NH2
show the reaction diagram
Escherichia coli--715653--?
4-aminobenzoyl-Cys-Phe-(trans)-Pro-Val-Cys-(NO2)-Tyr-NH24-aminobenzoyl-Cys-Phe-(cis)-Pro-Val-Cys-(NO2)-Tyr-NH2
show the reaction diagram
Escherichia coli--715653--?
acetyl-Ala-Ala-(cis)-Pro-Ala-Lys-NH2acetyl-Ala-Ala-(trans)-Pro-Ala-Lys-NH2
show the reaction diagram
Homo sapiens--650106-650106?
acetyl-Ala-Ala-Ser(PO3H2)-(cis)-Pro-Arg-NH-4-nitroanilideacetyl-Ala-Ala-Ser(PO3H2)-(trans)-Pro-Arg-NH-4-nitroanilide
show the reaction diagram
Mus musculus--679822--?
acetyl-Ala-Ala-Ser(PO3H2)-(cis)-Pro-Arg-NH-4-nitroanilideacetyl-Ala-Ala-Ser(PO3H2)-(trans)-Pro-Arg-NH-4-nitroanilide
show the reaction diagram
Homo sapiens--650106-650106?
AGL24 protein?
show the reaction diagram
Arabidopsis thaliana-cis/trans conformational change of phosphorylated Ser/Thr-Pro motif. The interaction between Pin1At and AGL24 mediates the AGL24 stability in the nucleus705728--?
Ala-Ala-(cis)-Pro-AlaAla-Ala-(trans)-Pro-Ala
show the reaction diagram
Homo sapiens--650106-650106?
Ala-Ala-(trans)-Pro-PheAla-Ala-(cis)-Pro-Phe
show the reaction diagram
Mycoplasma genitalium--651071-651071r
Ala-Ala-Ala-(trans)-Pro-PheAla-Ala-Ala-(cis)-Pro-Phe
show the reaction diagram
Mycoplasma genitalium--651071-651071r
Ala-Gln-(cis)-Pro-PheAla-Gln-(trans)-Pro-Phe
show the reaction diagram
Onchocerca volvulusQ8IA80-652239-652239?
Ala-Gln-(cis)-Pro-PheAla-Gln-(trans)-Pro-Phe
show the reaction diagram
Caenorhabditis elegansQ7KFC0-652239-652239?
Ala-Glu-(cis)-Pro-PheAla-Glu-(trans)-Pro-Phe
show the reaction diagram
Onchocerca volvulusQ8IA80-652239-652239?
Ala-Glu-(cis)-Pro-PheAla-Glu-(trans)-Pro-Phe
show the reaction diagram
Caenorhabditis elegansQ7KFC0-652239-652239?
Ala-Glu-(cis)-Pro-Phe-4-nitroanilideAla-Glu-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Homo sapiens--690907--?
Ala-Ile-(cis)-Pro-PheAla-Ile-(trans)-Pro-Phe
show the reaction diagram
Onchocerca volvulusQ8IA80-652239-652239?
Ala-Ile-(cis)-Pro-PheAla-Ile-(trans)-Pro-Phe
show the reaction diagram
Caenorhabditis elegansQ7KFC0-652239-652239?
Ala-Leu-(cis)-Pro-PheAla-Leu-(trans)-Pro-Phe
show the reaction diagram
Onchocerca volvulusQ8IA80-652239-652239?
Ala-Leu-(cis)-Pro-PheAla-Leu-(trans)-Pro-Phe
show the reaction diagram
Caenorhabditis elegansQ7KFC0-652239-652239?
Ala-Nle-(cis)-Pro-PheAla-Nle-(trans)-Pro-Phe
show the reaction diagram
Onchocerca volvulusQ8IA80-652239-652239?
Ala-Nle-(cis)-Pro-PheAla-Nle-(trans)-Pro-Phe
show the reaction diagram
Caenorhabditis elegansQ7KFC0-652239-652239?
Ala-Ser(PO3H2)-(cis)-ProAla-Ser(PO3H2)-(trans)-Pro
show the reaction diagram
Homo sapiens--650106-650106?
Ala-Ser(PO3H2)-(cis)-Pro-ArgAla-Ser(PO3H2)-(trans)-Pro-Arg
show the reaction diagram
Homo sapiens--650106-650106?
Ala-Val-(cis)-Pro-PheAla-Val-(trans)-Pro-Phe
show the reaction diagram
Caenorhabditis elegansQ7KFC0-652239-652239?
amyloidbeta precursor protein?
show the reaction diagram
Homo sapiens-interaction with Thr688704154--?
barstar C40A/C82A/P27A?
show the reaction diagram
Homo sapiens-the mutant of barstar lacks complications arising from oxidation of Cys in wild-type or isomerization affecting the peptidyl-Pro27 bond. Refolding is comprised by several kinetically detectable folding phases. The slowest phase in refolding, the trans to cis isomerization of the Tyr47-Pro48 peptide bond being in cis conformation in the native state653822-653822?
cis-succinyl-Ala-Leu-Pro-Phe-p-nitroanilidetrans-succinyl-Ala-Leu-Pro-Phe-p-nitroanilide
show the reaction diagram
Homo sapiensP62942-678718--?
colicin M?
show the reaction diagram
Escherichia coli--715653--?
D-Glyceraldehyde 3-phosphateGlycerone phosphate
show the reaction diagram
Homo sapiens--2596-2596-
GFPRALPAWARPDYNPPLVE?
show the reaction diagram
Homo sapiens-a synthetic peptide, named PepD2, corresponding to residues 304-323 of NS5A704474--?
Glutaryl-Ala-Ala-(cis)-Pro-Phe 4-nitroanilideGlutaryl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Sus scrofa--2511-2511-
Glutaryl-Ala-Ala-(cis)-Pro-Phe 4-nitroanilideGlutaryl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Sus scrofa--2512-2512-
Glutaryl-Ala-Ala-Ala-(cis)-Pro-Phe 4-nitroanilideGlutaryl-Ala-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Sus scrofa--2511-2511-
Glutaryl-Ala-Gly-(cis)-Pro-Phe 4-nitroanilideGlutaryl-Ala-Gly-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Sus scrofa--2512-2512-
Glutaryl-Ala-Pro-(cis)-Phe 4-nitroanilideGlutaryl-Ala-Pro-(trans)-Phe 4-nitroanilide
show the reaction diagram
Sus scrofa--2511-2511-
hepatitis C virus NS5A protein?
show the reaction diagram
Homo sapiens-nonstructural 5A protein, NS5A, from the JFH1 hepatitis C virus strain. Mutations in this domain are linked to cyclosporin A resistance, substrate is the domain 2 of the nonstructural 5A protein, NS5A, from the JFH1 hepatitis C virus strain, recombinantly expressed His-tagged substrate. Determination of direct molecular interaction between NS5A-D2 and both cyclophilins by NMR spectrometry, overview704474--?
N-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Trypanosoma cruziB8XP936.9% activity compared to N-succinyl-Ala-Arg-(cis)-Pro-Phe-4-nitroanilide714320--?
N-succinyl-Ala-Ala-(cis)-Pro-Phe-p-nitroanilideN-succinyl-Ala-Ala-(trans)-Pro-Phe-p-nitroanilide
show the reaction diagram
Mycobacterium tuberculosisP65762-661643--?
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Homo sapiens--691452--?
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Homo sapiensQ96BP3-692291--?
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Spinacia oleraceaP82536-651323-651323?
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Pisum sativum--651842-651842?
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Zea mays--653563-653563?
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Caenorhabditis elegansP52014-652894-652894?
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Caenorhabditis elegans--651964-651964r
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Methanothermococcus thermolithotrophicusO52980-2525-2525r
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Lupinus luteusO49886-694993--?
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Trypanosoma cruziQ2I5R9-681821ratio kcat to Km value is 15400 per M and s-?
N-succinyl-Ala-Arg-(cis)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Arg-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Trypanosoma cruziB8XP93100% activity, Par45 shows a strong preference for a substrate with the basic Arg residue preceding Pro714320--?
N-succinyl-Ala-Glu-(cis)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Trypanosoma cruziB8XP937.6% activity compared to N-succinyl-Ala-Arg-(cis)-Pro-Phe-4-nitroanilide714320--?
N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Glu-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Homo sapiens--681404--?
N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Glu-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Trypanosoma cruziQ2I5R9-681821ratio kcat to Km value is 397000 per M and s-?
N-succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Leu-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Trypanosoma cruziB8XP9326.7% activity compared to N-succinyl-Ala-Arg-(cis)-Pro-Phe-4-nitroanilide714320--?
N-succinyl-Ala-Leu-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Zea mays--653563-653563?
N-succinyl-Ala-Leu-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Methanothermococcus thermolithotrophicusO52980-2525-2525r
N-succinyl-Ala-Phe-(cis)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Phe-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Trypanosoma cruziB8XP934.3% activity compared to N-succinyl-Ala-Arg-(cis)-Pro-Phe-4-nitroanilide714320--?
N-succinyl-Ala-Phe-(trans)-Pro-Phe-4-nitroanilideN-succinyl-Ala-Phe-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Zea mays--653563-653563?
peptidylproline (omega=180)peptidylproline (omega=0)
show the reaction diagram
Homo sapiensP62937computational study on protein dynamics, network of protein vibrations, comparison with structures from different species661082--?
peptidylproline (omega=180)peptidylproline (omega=0)
show the reaction diagram
Homo sapiens-solvent-assisted mechanism, H43 and Q52 are active sites660614--?
phosphorylated pro-apoptotic Bcl-2-associated X protein?
show the reaction diagram
Homo sapiens-Pin1 prevents activation of Bax, prevents Bax cleavage by calpain, and prevents Bax translocation to mitochondria, i.e. Bax705854--?
PP2A phosphatase with cis-P190PP2A phosphatase with trans-P190
show the reaction diagram
Saccharomyces cerevisiae, Oryctolagus cuniculus--662459--?
protein tau?
show the reaction diagram
Homo sapiens-interaction with Thr231 of tau in Alzheimer's disease704154--?
reduced carboxymethylated bovine alpha-lactalbuminreduced carboxymethylated bovine alpha-lactalbumin
show the reaction diagram
Escherichia coli--678149--?
RNA polymerase II?
show the reaction diagram
Homo sapiens, Rattus norvegicus-Pin1 modulates RNA polymerase II CTD domain during transcription cycles by interacting with numerous YSPTSPS heptapeptide repeats in the substrate protein704154--?
RNase A S-proteinRNase A S-protein
show the reaction diagram
Escherichia coli-partially folded678149action of enzyme greatly reduces the population of aggregated oligomeric species-?
RNAse T1?
show the reaction diagram
Bordetella pertussisP40415-693627--?
RNAse T1?
show the reaction diagram
Mycoplasma genitalium-rate-limiting isomerization of -(trans)-Pro to -(cis)-Pro. Disulfide-reduced and S-carboxymethylated form of a variant of Rnase T1 with Ser54Gly and Pro55Asn. The trigger factor accepts only unfolded protein substrates, no action on protein chains that have partially folded already652779-652779?
RNAse T1?
show the reaction diagram
Bacillus subtilis-reduced and carboxymethylated form of the S54G/P55N variant of RNAse T1. In the native state the Rnase T1 contains a single prolyl bond Tyr38-Pro39. Of all reduced and carboxymethylated RNAse T1 molecules, 85% fold in a monophasic and reversible reaction, which is limited in rate by the slow trans to cis isomerization at Pro39649837-649837?
RNAse T1?
show the reaction diagram
Escherichia coli-reduced and carboxymethylated RNAse T1, refolding by trans to cis isomerization of peptidyl-prolyl bonds at Pro39 and Pro55652525-652525?
Ser(PO3H2)-(cis)-Pro-ArgSer(PO3H2)-(trans)-Pro-Arg
show the reaction diagram
Homo sapiens--650106-650106?
Ser(PO3H2)-(cis)-Pro-Arg-NH-4-nitroanilideSer(PO3H2)-(trans)-Pro-Arg-NH-4-nitroanilide
show the reaction diagram
Homo sapiens--650106-650106?
serine/threonine protein kinase B?
show the reaction diagram
Homo sapiens-i.e. Akt, reduced activity with Akt mutants T92A/T450A and T92D/T450D. Akt-Pin1 interaction analysis using HA-tagged Akt and GST-tagged Pin1, overview706012--?
SOC1 protein?
show the reaction diagram
Arabidopsis thaliana-cis/trans conformational change of phosphorylated Ser/Thr-Pro motif705728--?
Suc-Ala-Ala-(trans)-Pro-Lys-p-nitroanilideSuc-Ala-Ala-(cis)-Pro-Lys-p-nitroanilide
show the reaction diagram
Homo sapiens, Saccharomyces cerevisiae--662459--?
Suc-Ala-Ala-(trans)-Pro-Phe-methylcoumarylamideSuc-Ala-Ala-(cis)-Pro-Phe-methylcoumarylamide
show the reaction diagram
Homo sapiens, Saccharomyces cerevisiae--662459--?
Suc-Ala-Ala-(trans)-Pro-Phe-p-nitroanilideSuc-Ala-Ala-(cis)-Pro-Phe-p-nitroanilide
show the reaction diagram
Homo sapiens, Saccharomyces cerevisiae--662459--?
Suc-Ala-Ala-cis-Pro-Phe-4-nitroanilideSuc-Ala-Ala-trans-Pro-Phe-4-nitroanilide
show the reaction diagram
Arabidopsis thalianaQ9SCY2cis/trans-isomerization706176--?
suc-Ala-Glu-(cis)-Pro-Phe-4-nitroanilidesuc-Ala-Glu-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Homo sapiens--694290--?
Suc-Ala-Glu-(trans)-Pro-Phe-p-nitroanilideSuc-Ala-Glu-(cis)-Pro-Phe-p-nitroanilide
show the reaction diagram
Homo sapiens, Saccharomyces cerevisiae--662459--?
Suc-Ala-Glu-Pro-Phe-4-nitroanilide?
show the reaction diagram
Homo sapiens--704154--?
Suc-Ala-Glu-Pro-Phe-7-amido-4-methylcoumarin?
show the reaction diagram
Homo sapiens, Rattus norvegicus--704154--?
Suc-Ala-Leu-cis-Pro-Phe-4-nitroanilideSuc-Ala-Leu-trans-Pro-Phe-4-nitroanilide
show the reaction diagram
Arabidopsis thalianaQ9SCY2cis/trans-isomerization706176--?
succinyl-Ala-(cis)-Pro-Phe-NH-4-nitroanilidesuccinyl-Ala-(trans)-Pro-Phe-NH-4-nitroanilide
show the reaction diagram
Homo sapiens--650106-650106?
succinyl-Ala-Ala-(cis)-Pro-Lys 4-methylcoumarin 7-amidesuccinyl-Ala-Ala-(trans)-Pro-Lys 4-methylcoumarin 7-amide
show the reaction diagram
Saccharomyces cerevisiae, Oryctolagus cuniculus--662459--?
Succinyl-Ala-Ala-(cis)-Pro-Phe 4-methylcoumarin 7-amideSuccinyl-Ala-Ala-(trans)-Pro-Phe 4-methylcoumarin 7-amide
show the reaction diagram
Gallus gallus--2522---
Succinyl-Ala-Ala-(cis)-Pro-Phe 4-methylcoumarin 7-amideSuccinyl-Ala-Ala-(trans)-Pro-Phe 4-methylcoumarin 7-amide
show the reaction diagram
Escherichia coli--2533---
Succinyl-Ala-Ala-(cis)-Pro-Phe 4-methylcoumarin 7-amideSuccinyl-Ala-Ala-(trans)-Pro-Phe 4-methylcoumarin 7-amide
show the reaction diagram
Saccharomyces cerevisiae, Oryctolagus cuniculus--662459--?
Succinyl-Ala-Ala-(cis)-Pro-Phe 4-methylcoumarin 7-amideSuccinyl-Ala-Ala-(trans)-Pro-Phe 4-methylcoumarin 7-amide
show the reaction diagram
Sus scrofa--2508trans2508-
succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Schistosoma mansoniQ26548-680801--?
succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Ricinus communisQ8VX73-694779--?
succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Haemaphysalis longicornisB2ZWT4, B2ZWT5-694932--?
succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Homo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9-716659--?
succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Rickettsia prowazekiiQ9ZCX638% of activity compared to succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide661913--?
succinyl-Ala-Ala-(cis)-Pro-Phe-NH-4-nitroanilidesuccinyl-Ala-Ala-(trans)-Pro-Phe-NH-4-nitroanilide
show the reaction diagram
Homo sapiens--650106-650106?
succinyl-Ala-Ala-(cis)-Pro-Phe-p-nitroanilidesuccinyl-Ala-Ala-(trans)-Pro-Phe-p-nitroanilide
show the reaction diagram
Streptococcus pneumoniae--662464--?
succinyl-Ala-Ala-(cis)-Pro-Phe-p-nitroanilidesuccinyl-Ala-Ala-(trans)-Pro-Phe-p-nitroanilide
show the reaction diagram
Neisseria gonorrhoeae-70fold decrease in activity compared with succinyl-Ala-Phe-(cis)-Pro-Phe-p-nitroanilide662909--?
succinyl-Ala-Ala-(trans)-Pro-Arg-p-nitroanilidesuccinyl-Ala-Ala-(cis)-Pro-Arg-p-nitroanilide
show the reaction diagram
Homo sapiens--651287-651287r
succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Mycoplasma genitalium--651071-651071r
succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Zea mays, Brassica napus, Solanum lycopersicum--653605-653605?
Succinyl-Ala-Ala-Pro-Phe 4-nitroanilideSuccinyl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Gallus gallus--2522-2522-
Succinyl-Ala-Ala-Pro-Phe 4-nitroanilideSuccinyl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Escherichia coli--2533, 2538---
Succinyl-Ala-Ala-Pro-Phe 4-nitroanilideSuccinyl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Homo sapiens--2527, 2531, 2539---
Succinyl-Ala-Ala-Pro-Phe 4-nitroanilideSuccinyl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Saccharomyces cerevisiae--2526---
Succinyl-Ala-Ala-Pro-Phe 4-nitroanilideSuccinyl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Bos taurus--2536---
Succinyl-Ala-Ala-Pro-Phe 4-nitroanilideSuccinyl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Methanothermococcus thermolithotrophicusO52980-2525---
Succinyl-Ala-Ala-Pro-Phe 4-nitroanilideSuccinyl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Legionella pneumophila--2527---
Succinyl-Ala-Ala-Pro-Phe 4-nitroanilideSuccinyl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Plasmodium falciparum--2555---
succinyl-Ala-Arg-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Arg-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Rickettsia prowazekiiQ9ZCX650% of activity compared to succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide661913--?
Succinyl-Ala-Gln-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Gln-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Gallus gallus--2522-2522-
succinyl-Ala-Gln-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Gln-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Rickettsia prowazekiiQ9ZCX665% of activity compared to succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide661913--?
succinyl-Ala-Gln-(cis)-Pro-Phe-p-nitroanilidesuccinyl-Ala-Gln-(trans)-Pro-Phe-p-nitroanilide
show the reaction diagram
Streptococcus pneumoniae-27% of the activity with succinyl-Ala-Ala-(cis)-Pro-Phe-p-nitroanilide662464--?
Succinyl-Ala-Glu-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Glu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Gallus gallus--2522-2522-
Succinyl-Ala-Glu-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Glu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Escherichia coli--2533---
Succinyl-Ala-Glu-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Glu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Homo sapiens--2531---
succinyl-Ala-Glu-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Homo sapiens--715863--?
succinyl-Ala-Glu-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Rickettsia prowazekiiQ9ZCX611% of activity compared to succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide661913--?
succinyl-Ala-Glu-(cis)-Pro-Phe-p-nitroanilidesuccinyl-Ala-Glu-(trans)-Pro-Phe-p-nitroanilide
show the reaction diagram
Streptococcus pneumoniae-13% of the activity with succinyl-Ala-Ala-(cis)-Pro-Phe-p-nitroanilide662464--?
succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Glu-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Homo sapiens, Saccharomyces cerevisiae--649847-649847?
succinyl-Ala-Glu-(trans)-Pro-Phe-7-amido-4-methylcoumarinsuccinyl-Ala-Glu-(cis)-Pro-Phe-7-amido-4-methylcoumarin
show the reaction diagram
Mus musculus--650816-650816r
Succinyl-Ala-Gly-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Gly-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Gallus gallus--2522-2522-
Succinyl-Ala-Gly-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Gly-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Escherichia coli--2533---
Succinyl-Ala-Gly-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Gly-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Homo sapiens--2531---
succinyl-Ala-Gly-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Gly-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Homo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9-716659--?
succinyl-Ala-Gly-(cis)-Pro-Phe-p-nitroanilidesuccinyl-Ala-Gly-(trans)-Pro-Phe-p-nitroanilide
show the reaction diagram
Streptococcus pneumoniae-37% of the activity with succinyl-Ala-Ala-(cis)-Pro-Phe-p-nitroanilide662464--?
Succinyl-Ala-His-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-His-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Gallus gallus--2522-2522-
Succinyl-Ala-His-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-His-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Escherichia coli--2533---
succinyl-Ala-His-(trans)-Pro-Phe-4-nitroanilidesuccinyl-Ala-His-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Mycoplasma genitalium--651071-651071r
Succinyl-Ala-Leu-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Leu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Gallus gallus--2522-2522-
Succinyl-Ala-Leu-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Leu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Escherichia coli--2533---
Succinyl-Ala-Leu-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Leu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Homo sapiens--2531---
Succinyl-Ala-Leu-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Leu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Methanothermococcus thermolithotrophicusO52980-2525---
succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Leu-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Rickettsia prowazekiiQ9ZCX6-661913--?
succinyl-Ala-Leu-(cis)-Pro-Phe-p-nitroanilidesuccinyl-Ala-Leu-(trans)-Pro-Phe-p-nitroanilide
show the reaction diagram
Plasmodium falciparum--662803--?
succinyl-Ala-Leu-(cis)-Pro-Phe-p-nitroanilidesuccinyl-Ala-Leu-(trans)-Pro-Phe-p-nitroanilide
show the reaction diagram
Haemonchus contortusQ4G338-663015--?
succinyl-Ala-Leu-(cis)-Pro-Phe-p-nitroanilidesuccinyl-Ala-Leu-(trans)-Pro-Phe-p-nitroanilide
show the reaction diagram
Streptococcus pneumoniae-67% of the activity with succinyl-Ala-Ala-(cis)-Pro-Phe-p-nitroanilide662464--?
succinyl-Ala-Leu-(trans)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Mycoplasma genitalium--651071-651071r
Succinyl-Ala-Lys-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Lys-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Gallus gallus--2522-2522-
Succinyl-Ala-Lys-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Lys-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Escherichia coli--2533---
Succinyl-Ala-Lys-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Lys-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Homo sapiens--2527, 2531---
Succinyl-Ala-Lys-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Lys-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Legionella pneumophila--2527---
succinyl-Ala-Lys-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Lys-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Rickettsia prowazekiiQ9ZCX683% of activity compared to succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide661913--?
succinyl-Ala-Nle-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Nle-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Rickettsia prowazekiiQ9ZCX6194% of activity compared to succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide661913--?
Succinyl-Ala-Phe-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Phe-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Gallus gallus--2522-2522-
Succinyl-Ala-Phe-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Phe-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Escherichia coli--2533---
Succinyl-Ala-Phe-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Phe-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Homo sapiens--2531---
Succinyl-Ala-Phe-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Phe-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Acanthamoeba polyphaga MimivirusQ5UP71mimicyp lacks peptidyl-prolyl isomerase activity693639--?
succinyl-Ala-Phe-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Phe-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Homo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9-716659--?
succinyl-Ala-Phe-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Phe-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Rickettsia prowazekiiQ9ZCX633% of activity compared to succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide661913--?
succinyl-Ala-Phe-(cis)-Pro-Phe-p-nitroanilidesuccinyl-Ala-Phe-(trans)-Pro-Phe-p-nitroanilide
show the reaction diagram
Neisseria gonorrhoeae--662909--?
succinyl-Ala-Phe-(cis)-Pro-Phe-p-nitroanilidesuccinyl-Ala-Phe-(trans)-Pro-Phe-p-nitroanilide
show the reaction diagram
Streptococcus pneumoniae-35% of the activity with succinyl-Ala-Ala-(cis)-Pro-Phe-p-nitroanilide662464--?
succinyl-Ala-Phe-(trans)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Phe-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Mycoplasma genitalium--651071-651071r
succinyl-Ala-Phe-(trans)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Phe-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Bacillus subtilis--649837-649837?
succinyl-Ala-Phe-(trans)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Phe-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Escherichia coli--649847-649847?
succinyl-Ala-Phe-(trans)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Phe-(cis)-Pro-Phe-4-nitroanilide
show the reaction diagram
Escherichia coli--652525-652525?
succinyl-Ala-Phe-Pro-Phe-4-nitroanilide?
show the reaction diagram
Escherichia coli--680509--?
succinyl-Ala-Ser-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Ser-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Rickettsia prowazekiiQ9ZCX623% of activity compared to succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide661913--?
Succinyl-Ala-Val-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ala-Val-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Homo sapiens--2531-2531-
succinyl-Ala-Val-(cis)-Pro-Phe-4-nitroanilidesuccinyl-Ala-Val-(trans)-Pro-Phe-4-nitroanilide
show the reaction diagram
Rickettsia prowazekiiQ9ZCX618% of activity compared to succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide661913--?
succinyl-Ala-Val-(cis)-Pro-Phe-p-nitroanilidesuccinyl-Ala-Val-(trans)-Pro-Phe-p-nitroanilide
show the reaction diagram
Streptococcus pneumoniae-76% of the activity with succinyl-Ala-Ala-(cis)-Pro-Phe-p-nitroanilide662464--?
Succinyl-Arg-Leu-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Arg-Leu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Homo sapiens--2531-2531-
Succinyl-Leu-Leu-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Leu-Leu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Homo sapiens--2531-2531-
Succinyl-Phe-Leu-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Phe-Leu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Homo sapiens--2531-2531-
Succinyl-Ser-Leu-(cis)-Pro-Phe 4-nitroanilideSuccinyl-Ser-Leu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
Homo sapiens--2531-2531-
Trp-Phe-Tyr-pSer-Pro-Arg-4-nitroanilide?
show the reaction diagram
Homo sapiens--715863--?
Trp-Phe-Tyr-Ser(PO3H2)-(cis)-Pro-Arg-4-nitroanilideTrp-Phe-Tyr-Ser(PO3H2)-(trans)-Pro-Arg-4-nitroanilide
show the reaction diagram
Homo sapiens--690907--?
VYKS-(cis)-PVVSGDTS-(cis)-PRHLVYKS-(trans)-PVVSGDTS-(trans)-PRHL
show the reaction diagram
Bordetella pertussisP40415interconversion occurs at both P5 and P13693627--?
interleukin-2 tyrosine kinase?
show the reaction diagram
Homo sapiens-catalytic activity of interleukin-2 tyrosine kinase is inhibited by peptidylprolyl isomerase activity of cyclophilin A. Proline-dependent conformational switch within the interleukin-2 tyrosine kinase SH2 domain regulates substrate recognition and mediates regulatory interactions with the active site of cyclophilin A653685-653685?
additional information?-Homo sapiens--2527---
additional information?-Sus scrofa-enzyme enhances the refolding of urea-denatured ribonuclease A2507---
additional information?-Sus scrofa-enzyme increases refolding of denatured type III collagen2508---
additional information?-Sus scrofa-catalyzes slow steps in the refolding of a number of proteins. The efficiency of catalysis depends on the accessibility for the isomerase of the particular proline peptide bonds in the refolding protein chain2509---
additional information?-Escherichia coli-increases the refolding of type IV procollagen2513---
additional information?-Gallus gallus-catalyzes the refolding of type III collagen2522---
additional information?-Sus scrofa-increases refolding of cytochrome c and RNAase T12517---
additional information?-Bos taurus-catalyzes refolding of RNAase T12536---
additional information?-Escherichia coli-catalyzes the refolding of thermally denatured type III collagen2533---
additional information?-Homo sapiens-substrate specificity of the 3 isoforms2531---
additional information?-Homo sapiens-cyclophilin B complexed to cyclosporin A inhibits phosphatase activity of recombinant human calcineurin653828-653828?
additional information?-Sus scrofa-isomerase activity of peptidylprolyl isomerase is independent of the chaperone activity. The proper molar ratio is important for the chaperone activity. The cysteine residues of peptidylprolyl isomerase may be a peptide binding site, and may be an essential group for the chaperone function653787-653787?
additional information?-Mycoplasma genitalium-neither the active domain nor the intact protein can catalyze the cis/trans isomerization of the tripeptide Ala-Pro-Phe, less than 5% of the activity with succinyl-Ala-Ala-Pro-Phe-p-nitroanilide is observed with: succinyl-Ala-Gly-Pro-Phe-p-nitroanilide, succinyl-Ala-Lys-Pro-Phe-p-nitroanilide, succinyl-Ala-Glu-Pro-Phe-p-nitroanilide. The organism is devoid of all known peptidyl-prolyl cis/trans isomerases except the trigger factor. The trigger factor shows dual function as chaperone and prolyl isomerase651071-651071?
additional information?-Caenorhabditis elegansQ7KFC0no activity with Ala-Ala-(cis)-Pro-Phe, Ala-Gly-(cis)-Pro-Phe, Ala-Phe-(cis)-Pro-Phe, Ala-Trp-(cis)-Pro-Phe, Ala-His-(cis)-Pro-Phe and Ala-Lys-(cis)-Pro-Phe652239-652239?
additional information?-Onchocerca volvulusQ8IA80no activity with Ala-Ala-(cis)-Pro-Phe, Ala-Gly-(cis)-Pro-Phe, Ala-Val-(cis)-Pro-Phe, Ala-Phe-(cis)-Pro-Phe, Ala-Trp-(cis)-Pro-Phe, Ala-His-(cis)-Pro-Phe and Ala-Lys-(cis)-Pro-Phe652239-652239?
additional information?-Homo sapiens-no catalysis is observed with the substrates Ala-(cis)-Pro, Ala-Ala-(cis)-Pro, Ala-(cis)-Pro-Ala, Ser-(cis)-Pro and Ser(PO3H2)-(cis)-Pro650106-650106?
additional information?-Bacillus subtilis-only two enzymes, the cyclophilin and the trigger factor, contribute to the peptidylprolyl isomerase activity649837-649837?
additional information?-Escherichia coliP45523the enzyme has peptidylprolyl isomerase activity and chaperone activity652932-652932?
additional information?-Thermococcus sp.-the enzyme shows chaperone-like protein refolding activity in addition to peptidylprolyl isomerase649714-649714?
additional information?-Methanothermococcus thermolithotrophicus-the IF domain is a novel-folding motif and exposes a hydrophobic surface, which is considered to play an important role in the chaperone-like activity652911-652911?
additional information?-Homo sapiens-the mechanism determining the substrate specificity seems to be different between hPAR14 and hPin1652844-652844?
additional information?-Homo sapiens-the presence of cyclophilin A in the human immunodeficiency virus type 1, HIV-1, is required for HIV-1 to infect and replicate2523---
additional information?-Sus scrofa-the enzyme is essential for protein folding during protein synthesis and may be involved in events, such as those occuring early in T-cell activation2510---
additional information?-Homo sapiens, Bos taurus-the functional role may involve signal transduction of specific genes essential for T-lymphocyte activation and proliferation2516---
additional information?-Escherichia coli-the folding of some exported proteins may be catalyzed by the periplasmic proline isomerase2554---
additional information?-Legionella pneumophila-the enzyme is not essential for Legionella pneumophila although the Cyp18-negative mutant strain is less infective for Acanthamoeba castellanii2527---
additional information?-Homo sapiensP62937cyclophilin A performs an essential function in HIV-1 replication, possibly helping to disassemble the capsid core upon infection2541---
additional information?-Caenorhabditis elegans-class3 cyclophilins are involved in cellular responses to stress caused by changes in redox environment or by upregulation of cellular activity651964-651964?
additional information?-Thermococcus sp.-cold-shock-inducible peptidyl-prolyl cis-trans isomerase with activities to trap and refold denatured proteins.The enzyme might be important at growth temperatures lower than the optimum in Thermococcus sp. KS-1649714-649714?
additional information?-Saccharomyces cerevisiae-cyclophilin A and Ess1 function in parallel pathways and act on common targets by a mechanism that requires prolyl isomerization. One of these targets is the Sin3-Rdp3 histone deacetylase complex. Cyclophilin A increases and Ess1 decreases disruption of gene silencing by this complex. Ess1 and cyclophilin A modulate the activity of the Sin3-Rdp3 complex, and excess histone deacetylation causes mitotic arrest in ess1 mutants650973-650973?
additional information?-Homo sapiens-enzyme is required for cell cycle progression650106-650106?
additional information?-Vicia faba-expression of the transcript in the leaf tissue is regulated by light and induced by heat shock653459-653459?
additional information?-Homo sapiens-folding helper enzyme that plays a role in cell-cycle and chromatin remodeling652918-652918?
additional information?-Triticum aestivum-heat-stress-induced protein653500-653500?
additional information?-Arabidopsis thalianaP34790, P34791not essential for protein import into chloroplast651848-651848?
additional information?-Bacillus subtilis-only two enzymes, the cyclophilin and the trigger factor, contribute to the peptidylprolyl isomerase activity. The prolyl isomerases become essential for growth under starvation conditions649837-649837?
additional information?-Homo sapiens-peptidylprolyl isomerase Pin1 interacts with Cdk9-phosphorylated hSpt5. Cdk9 dependent phosphorylation of Rpb1 and hSpt5 followed by Pin1 interaction might contribute to the regulation of transcription, pre-mRNA maturation and the dynamics of proteins in interphase and mitosis652866-652866?
additional information?-Homo sapiensQ13526substrates are proteins involved in regulation of cell cycle, transcription, Alzheimer‘s disease, and cancer pathogenesis652417-652417?
additional information?-Mus musculus-the enzyme is involved in cell cycle progression650816-650816?
additional information?-Cricetulus griseus-the kinesin-related protein, KRMP1 is a mitotic target regulated by Pin1 and vice versa652182-652182?
additional information?-Saccharomyces cerevisiae-the peptidylprolyl isomerase activity of cyclophilin A promotes proper subcellular localization of Zpr1p. Zpr1p is an essential zinc-finger-containing protein that translocates to the nucleus in response to groth stimuli653218-653218?
additional information?-Homo sapiens-the peptidylprolyl isomerase Cyp40, FKBP51 and FKBP52 are components of the Hsp90 chaperone complex. The peptidylprolyl isomerase monomers bind to a Hsp90 dimer. The three isomerase differ both in their affinity for Hsp90 and their chaperone activity suggesting that they play distinct roles in the Hsp90 chaperone complex652854-652854?
additional information?-Mycoplasma genitalium-the trigger factor accepts only unfolded protein substrates, no action on protein chains that have partially folded already652779-652779?
additional information?-Escherichia coli-trigger factor's peptidyl-prolyl cis/trans isomerase activity is not essential for the folding of cytosolic proteins652525-652525?
additional information?-Plasmodium falciparum-enzyme inibits the phosphatase activity of calcineurin independently of FK506 binding. Enzyme also inhibits thermal aggregation of two model substrates indicating chaperone proterties662803---
additional information?-Mus musculus, Oryctolagus cuniculus-general function of enzyme in binding of cargo for retrograde movement along microtubules662319---
additional information?-Neisseria gonorrhoeae-protein is not involved in binding to macrophages and does not impair the ability of macrophages to phagocytose the gonococci662909---
additional information?-Homo sapiens-selective for substrate SRC-3, phosphorylated steroid receptor coactivator 3. Enzyme and SRC-3 synergistically activate nuclear-receptor-regulated transcription662861---
additional information?-Homo sapiens-enzyme isoform Pin1 interacts with Bruton tyrosine kinase in a cell-cycle dependent manner, regulating the Bruton tyrosine kinase expression level. Interaction requires a functionally intact tyrosine kinase and occurs via S21 and S115 residues of the kinase680662---
additional information?-Oryctolagus cuniculusQ9TTC6cyclophilin A mediates the polymerization and matrix assembly of hensin, a multifunctional, multi-domain protein implicated in the regulation of epithelial differentiation693250---
additional information?-Bordetella pertussisP40415isoform Par27 displays both prolyl-peptidyl isomerase and chaperone activities in vitro693627---
additional information?-Homo sapiens-isoform Pin1 modulates oxidative stress-induced neurofilament NF-H phosphorylation. In vitro, the addition of Pin1 substantially increases phosphorylation of NF-H KSP repeats by proline-directed kinases, Erk1/2, Cdk5/p35, and JNK3 in a concentration-dependent manner. In vivo, dominant-negative Pin1 and Pin1 small interfering RNA inhibit epidermal growth factor-induced NF-H phosphorylation693136---
additional information?-Escherichia coli-PpiD interacts with misfolded proteins such as scrambled ribonuclease A or with D-somatostatin, with the amino acid sequence AGSKNFFWKTFTSS, and derived model peptides. Substrate specificity of PpiD is less specific than that for isoform SurA. The substrate specificity of PpiD is determined more by the hydrophobicity of residues in the model peptides than the presence of aromatic residues692303---
additional information?-Arabidopsis thaliana-Arabidopsis thaliana PIN1-type parvulin 1, Pin1At, controls floral transition by accelerating cis/trans isomerization of the phosphorylated Ser/Thr-Pro motifs in two MADS-domain transcription factors, SOC1 and AGL24705728---
additional information?-Arabidopsis thalianaQ9SCY2AtFKBP13 and AtCYP20-2 possess peptidyl-prolyl cis/trans isomerase activity and might be involved in protein folding catalysis706176---
additional information?-Xenopus laevis, Rattus norvegicusO42123FKBP12 and FKBP52 catalyze cis/trans isomerization of regions of TRPC1 implicated in controlling channel opening, molecular mechanism of FKBP52 in TRPC1 channel opening, overview705910---
additional information?-Homo sapiens-incorporation of the HCV polymerase into the replication complex depends on its interaction with a cellular chaperone protein, cyclosporine inhibits HCV replication by blocking this critical interaction and the PPIase activity of CyPA, modeling of the pathway, overview. CyPA is associated with CRC-incorporated HCV replicase in a cyclosporine-sensitive manner705430---
additional information?-Mus musculus, Homo sapiens-Par14 behaves as a component of the preribosomal ribonucleoprotein, pre-rRNP, complexes in vivo interacting via its residues 36-41, proteomics analysis of the Par14-associated pre-rRNP complexes, overview705715---
additional information?-Homo sapiens-Pin1 enhances Plk1-mediated phosphorylation of the centrosome protein Cep55, overview703024---
additional information?-Homo sapiens-Pin1 interacts with human T-cell leukemia virus type 1 Tax, phosphorylated at Ser258, and modulates its activation of NF-kappaB. Pin1 contributes to Tax signaling through NF-kappaB, and it cooperates with Tax to enhance cellular proliferation705427---
additional information?-Homo sapiens-Pin1 interacts with NF-kappaB via its WW domain703021---
additional information?-Homo sapiens, Rattus norvegicus-Pin1 is a peptidyl prolyl cis-trans isomerase that isomerizes phospho-serine/threonine-proline motifs of its target proteins from cis to trans, it functions in concert with proline directed kinases, such as cyclin-dependent protein kinases, extracellular signal-regulated kinases, and c-Jun N-terminal kinase, that produce the phosphorylated substrates of the isomerase, and with protein phosphatases, such as protein phosphatase 1A and 2B, in a wide range of cellular processes including cell division, DNA damage response, and gene transcription, and in susceptibilty to cancer and neurogenerative diseases, regulation, overview704154---
additional information?-Rattus norvegicus-prolyl isomerase Pin1 recognizes and induces cis-trans isomerization of pSer/Thr-Pro bonds, conferring phosphorylation-dependent conformational changes relevant for protein function. Pin1 can directly modulate the NF dephosphorylation mediated by PP2A, independent of JNK, extracellular signal-regulated kinase, and Cdk5 pathways705286---
additional information?-Homo sapiens-prolyl isomerase Pin1 recognizes and induces cis-trans isomerization of pSer/Thr-Pro bonds, conferring phosphorylationdependent conformational changes relevant for protein function. Pin1 can directly modulate the NF dephosphorylation mediated by PP2A, independent of JNK, extracellular signal-regulated kinase, and Cdk5 pathways705286---
additional information?-Homo sapiens-promyelocytic leukemia protein, PML, and silencing mediator for retinoic acid and thyroid hormone receptor, SMRT, are Pin1 substrates705066---
additional information?-Campylobacter jejuni-Cj0596 has PPIase activity, cleavage of N-Suc-Ala-Ala-Pro-Phe-4-nitroanilide702908---
additional information?-Bordetella pertussis-Par27 exhibits both chaperone and PPIase activities in vitro. Full-length and isolated PPIase domain show PPIase activity using either reduced carboxymethylated RNAse T1 or a 16-mer peptide as substrates, product analysis by NMR, overview. Functional analysis of enzyme domains and structure modeling, overview705408---
additional information?-Homo sapiens, Rattus norvegicus-Pin1 can stimulate proteins phosphorylation, e.g. of the RNA polymerase II CTD domain, but it can also inhibit protein dephosphorylation, e.g. of NFAT transcription factor or calcineurin. Pin1 interacts with neuronal cytoskeleton proteins such as tau, amyloid-beta protein precursor, alpha-synuclein, and with neurofilaments704154---
additional information?-Homo sapiens, Rattus norvegicus-Pin1 inhibits the dephosphorylation of NF by PP2A in vitro705286---
additional information?-Homo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9cyclophilin activity against short peptides is correlated with an ability to ligate cyclosporin716659---
additional information?-Homo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9cyclophilin activity against short peptides is correlated with an ability to ligate cyclosporine716659---
additional information?-Homo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9cyclophilins catalyze the cis-trans-isomerization of pralines, cyclophilin activity against short peptides is correlated with an ability to ligate cyclosporin716659---
additional information?-Trypanosoma cruziB8XP93Par45 does not accelerate the cis/trans interconversion of acidic substrates containing Glu-Pro bonds714320---
additional information?-Homo sapiens-Pin1 specifically recognizes the phosphorylated serine/threonine residue followed by proline. Pin1 binds preferentially to the phosphorylated Ser16-Pro17 motif of the capsid core of the human immunodeficiency virus type 1715524---

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)
COMMENTARY PRODUCTLITERATURE
(Product)
AGL24 protein?
show the reaction diagram
Arabidopsis thaliana-cis/trans conformational change of phosphorylated Ser/Thr-Pro motif. The interaction between Pin1At and AGL24 mediates the AGL24 stability in the nucleus705728--
amyloidbeta precursor protein?
show the reaction diagram
Homo sapiens-interaction with Thr688704154--
colicin M?
show the reaction diagram
Escherichia coli--715653--
hepatitis C virus NS5A protein?
show the reaction diagram
Homo sapiens-nonstructural 5A protein, NS5A, from the JFH1 hepatitis C virus strain. Mutations in this domain are linked to cyclosporin A resistance704474--
phosphorylated pro-apoptotic Bcl-2-associated X protein?
show the reaction diagram
Homo sapiens-Pin1 prevents activation of Bax, prevents Bax cleavage by calpain, and prevents Bax translocation to mitochondria705854--
PP2A phosphatase with cis-P190PP2A phosphatase with trans-P190
show the reaction diagram
Saccharomyces cerevisiae, Oryctolagus cuniculus--662459--
protein tau?
show the reaction diagram
Homo sapiens-interaction with Thr231 of tau in Alzheimer's disease704154--
RNA polymerase II?
show the reaction diagram
Homo sapiens, Rattus norvegicus-Pin1 modulates RNA polymerase II CTD domain during transcription cycles by interacting with numerous YSPTSPS heptapeptide repeats in the substrate protein704154--
serine/threonine protein kinase B?
show the reaction diagram
Homo sapiens--706012--
SOC1 protein?
show the reaction diagram
Arabidopsis thaliana-cis/trans conformational change of phosphorylated Ser/Thr-Pro motif705728--
interleukin-2 tyrosine kinase?
show the reaction diagram
Homo sapiens-catalytic activity of interleukin-2 tyrosine kinase is inhibited by peptidylprolyl isomerase activity of cyclophilin A. Proline-dependent conformational switch within the interleukin-2 tyrosine kinase SH2 domain regulates substrate recognition and mediates regulatory interactions with the active site of cyclophilin A653685-653685
additional information?-Homo sapiens--2527--
additional information?-Homo sapiens-the presence of cyclophilin A in the human immunodeficiency virus type 1, HIV-1, is required for HIV-1 to infect and replicate2523--
additional information?-Sus scrofa-the enzyme is essential for protein folding during protein synthesis and may be involved in events, such as those occuring early in T-cell activation2510--
additional information?-Homo sapiens, Bos taurus-the functional role may involve signal transduction of specific genes essential for T-lymphocyte activation and proliferation2516--
additional information?-Escherichia coli-the folding of some exported proteins may be catalyzed by the periplasmic proline isomerase2554--
additional information?-Legionella pneumophila-the enzyme is not essential for Legionella pneumophila although the Cyp18-negative mutant strain is less infective for Acanthamoeba castellanii2527--
additional information?-Homo sapiensP62937cyclophilin A performs an essential function in HIV-1 replication, possibly helping to disassemble the capsid core upon infection2541--
additional information?-Caenorhabditis elegans-class3 cyclophilins are involved in cellular responses to stress caused by changes in redox environment or by upregulation of cellular activity651964-651964
additional information?-Thermococcus sp.-cold-shock-inducible peptidyl-prolyl cis-trans isomerase with activities to trap and refold denatured proteins.The enzyme might be important at growth temperatures lower than the optimum in Thermococcus sp. KS-1649714-649714
additional information?-Saccharomyces cerevisiae-cyclophilin A and Ess1 function in parallel pathways and act on common targets by a mechanism that requires prolyl isomerization. One of these targets is the Sin3-Rdp3 histone deacetylase complex. Cyclophilin A increases and Ess1 decreases disruption of gene silencing by this complex. Ess1 and cyclophilin A modulate the activity of the Sin3-Rdp3 complex, and excess histone deacetylation causes mitotic arrest in ess1 mutants650973-650973
additional information?-Homo sapiens-enzyme is required for cell cycle progression650106-650106
additional information?-Vicia faba-expression of the transcript in the leaf tissue is regulated by light and induced by heat shock653459-653459
additional information?-Homo sapiens-folding helper enzyme that plays a role in cell-cycle and chromatin remodeling652918-652918
additional information?-Triticum aestivum-heat-stress-induced protein653500-653500
additional information?-Arabidopsis thalianaP34790, P34791not essential for protein import into chloroplast651848-651848
additional information?-Bacillus subtilis-only two enzymes, the cyclophilin and the trigger factor, contribute to the peptidylprolyl isomerase activity. The prolyl isomerases become essential for growth under starvation conditions649837-649837
additional information?-Homo sapiens-peptidylprolyl isomerase Pin1 interacts with Cdk9-phosphorylated hSpt5. Cdk9 dependent phosphorylation of Rpb1 and hSpt5 followed by Pin1 interaction might contribute to the regulation of transcription, pre-mRNA maturation and the dynamics of proteins in interphase and mitosis652866-652866
additional information?-Homo sapiensQ13526substrates are proteins involved in regulation of cell cycle, transcription, Alzheimer‘s disease, and cancer pathogenesis652417-652417
additional information?-Mus musculus-the enzyme is involved in cell cycle progression650816-650816
additional information?-Cricetulus griseus-the kinesin-related protein, KRMP1 is a mitotic target regulated by Pin1 and vice versa652182-652182
additional information?-Saccharomyces cerevisiae-the peptidylprolyl isomerase activity of cyclophilin A promotes proper subcellular localization of Zpr1p. Zpr1p is an essential zinc-finger-containing protein that translocates to the nucleus in response to groth stimuli653218-653218
additional information?-Homo sapiens-the peptidylprolyl isomerase Cyp40, FKBP51 and FKBP52 are components of the Hsp90 chaperone complex. The peptidylprolyl isomerase monomers bind to a Hsp90 dimer. The three isomerase differ both in their affinity for Hsp90 and their chaperone activity suggesting that they play distinct roles in the Hsp90 chaperone complex652854-652854
additional information?-Mycoplasma genitalium-the trigger factor accepts only unfolded protein substrates, no action on protein chains that have partially folded already652779-652779
additional information?-Escherichia coli-trigger factor's peptidyl-prolyl cis/trans isomerase activity is not essential for the folding of cytosolic proteins652525-652525
additional information?-Plasmodium falciparum-enzyme inibits the phosphatase activity of calcineurin independently of FK506 binding. Enzyme also inhibits thermal aggregation of two model substrates indicating chaperone proterties662803--
additional information?-Mus musculus, Oryctolagus cuniculus-general function of enzyme in binding of cargo for retrograde movement along microtubules662319--
additional information?-Neisseria gonorrhoeae-protein is not involved in binding to macrophages and does not impair the ability of macrophages to phagocytose the gonococci662909--
additional information?-Homo sapiens-selective for substrate SRC-3, phosphorylated steroid receptor coactivator 3. Enzyme and SRC-3 synergistically activate nuclear-receptor-regulated transcription662861--
additional information?-Oryctolagus cuniculusQ9TTC6cyclophilin A mediates the polymerization and matrix assembly of hensin, a multifunctional, multi-domain protein implicated in the regulation of epithelial differentiation693250--
additional information?-Arabidopsis thaliana-Arabidopsis thaliana PIN1-type parvulin 1, Pin1At, controls floral transition by accelerating cis/trans isomerization of the phosphorylated Ser/Thr-Pro motifs in two MADS-domain transcription factors, SOC1 and AGL24705728--
additional information?-Arabidopsis thalianaQ9SCY2AtFKBP13 and AtCYP20-2 possess peptidyl-prolyl cis/trans isomerase activity and might be involved in protein folding catalysis706176--
additional information?-Xenopus laevis, Rattus norvegicusO42123FKBP12 and FKBP52 catalyze cis/trans isomerization of regions of TRPC1 implicated in controlling channel opening, molecular mechanism of FKBP52 in TRPC1 channel opening, overview705910--
additional information?-Homo sapiens-incorporation of the HCV polymerase into the replication complex depends on its interaction with a cellular chaperone protein, cyclosporine inhibits HCV replication by blocking this critical interaction and the PPIase activity of CyPA, modeling of the pathway, overview. CyPA is associated with CRC-incorporated HCV replicase in a cyclosporine-sensitive manner705430--
additional information?-Mus musculus, Homo sapiens-Par14 behaves as a component of the preribosomal ribonucleoprotein, pre-rRNP, complexes in vivo interacting via its residues 36-41, proteomics analysis of the Par14-associated pre-rRNP complexes, overview705715--
additional information?-Homo sapiens-Pin1 enhances Plk1-mediated phosphorylation of the centrosome protein Cep55, overview703024--
additional information?-Homo sapiens-Pin1 interacts with human T-cell leukemia virus type 1 Tax, phosphorylated at Ser258, and modulates its activation of NF-kappaB. Pin1 contributes to Tax signaling through NF-kappaB, and it cooperates with Tax to enhance cellular proliferation705427--
additional information?-Homo sapiens-Pin1 interacts with NF-kappaB via its WW domain703021--
additional information?-Homo sapiens, Rattus norvegicus-Pin1 is a peptidyl prolyl cis-trans isomerase that isomerizes phospho-serine/threonine-proline motifs of its target proteins from cis to trans, it functions in concert with proline directed kinases, such as cyclin-dependent protein kinases, extracellular signal-regulated kinases, and c-Jun N-terminal kinase, that produce the phosphorylated substrates of the isomerase, and with protein phosphatases, such as protein phosphatase 1A and 2B, in a wide range of cellular processes including cell division, DNA damage response, and gene transcription, and in susceptibilty to cancer and neurogenerative diseases, regulation, overview704154--
additional information?-Rattus norvegicus-prolyl isomerase Pin1 recognizes and induces cis-trans isomerization of pSer/Thr-Pro bonds, conferring phosphorylation-dependent conformational changes relevant for protein function. Pin1 can directly modulate the NF dephosphorylation mediated by PP2A, independent of JNK, extracellular signal-regulated kinase, and Cdk5 pathways705286--
additional information?-Homo sapiens-prolyl isomerase Pin1 recognizes and induces cis-trans isomerization of pSer/Thr-Pro bonds, conferring phosphorylationdependent conformational changes relevant for protein function. Pin1 can directly modulate the NF dephosphorylation mediated by PP2A, independent of JNK, extracellular signal-regulated kinase, and Cdk5 pathways705286--
additional information?-Homo sapiens-promyelocytic leukemia protein, PML, and silencing mediator for retinoic acid and thyroid hormone receptor, SMRT, are Pin1 substrates705066--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
No entries in this field

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
Mg2+Homo sapiens-stimulation662459
Mg2+Oryctolagus cuniculus-at least 3fold stimulation662459
Mg2+Saccharomyces cerevisiae-at least 3fold stimulation; stimulation662459

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
(1R)-1,3-diphenyl-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylateHomo sapiens--680340 2D-image
(1R)-1,3-diphenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
(1R)-1-cyclohexyl-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
(1R)-1-naphthalen-2-yl-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
(1R)-1-phenyl-3-(3,4,5-trimethoxyphenyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
(1R)-1-[3-(diethenylcarbamoyl)phenyl]-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens-inhibition of FKBP12 cis-trans peptidylprolyl isomerase activity, but no activity in splenocyte mitogenesis assay for immunosuppression678715 2D-image
(1R)-3-(1,3-benzodioxol-5-yl)-1-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
(1R)-3-(3,4-dimethoxyphenyl)-1-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
(1R)-3-cyclohexyl-1-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
(1R)-3-cyclohexyl-1-phenylpropyl 1-[cyclohexyl(oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678713 2D-image
(1R)-3-phenyl-1-[3-(phenylcarbonyl)phenyl]propyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens-inhibition of FKBP12 cis-trans peptidylprolyl isomerase activity, but no activity in splenocyte mitogenesis assay for immunosuppression678715 2D-image
(1R,5S)-1-(phenylsulfonyl)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678742 2D-image
(1R,5S)-1-(phenylthio)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678742 2D-image
(1S)-1,3-diphenylpropyl 1-(benzylsulfonyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
(1S)-1-cyclohexyl-3-phenylpropyl (2R)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--680340 2D-image
(1S)-1-phenyl-3-(3,4,5-trimethoxyphenyl)propyl 1-(3,3-dimethylbutanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
(24aS)-17,17-dimethylhexadecahydropyrido[2,1-c][1,9,4]dioxazacyclohenicosine-1,14,18,19(3H,21)-tetroneHomo sapiens--680340 2D-image
(3S,26aR)-19,19-dimethyl-3-(2-phenylethyl)-12,13,14,15,18,19,24,25,26,26a-decahydro-3H,10H-4,8-(metheno)pyrido[2,1-c][1,9,17,4]trioxazacyclotricosine-1,16,20,21(11H,23H)-tetroneHomo sapiens--680340 2D-image
(6,8aR)-6-N,N-monophenylimino-8a-carboxyindolizidin-5-one methyl esterEscherichia coli-dissociation constant: above 0.2 mM652727 2D-image
(6R,8a,R)-6-(2-methylnaphthyl)-N-tert-butoxycarbonyl-6-amino-8a-carboxyindolizidin-5-one methyl esterEscherichia coli-dissociation constant: 0.017 mM652727 2D-image
(6R,8aR)-6-(2-methylnaphthyl)-N-acetyl-6-amino-8a-carboxyindolizidin-5-one methyl esterEscherichia coli-dissociation constant: 0.0015 mM652727 2D-image
(6R,8aR)-6-(2-methylnaphthyl)-N-benzyloxycarbonyl-6-amino-8a-carboxyindolizidin-5-one methyl esterEscherichia coli-dissociation constant: 0.047 mM652727 2D-image
(6R,8aR)-6-(2-methylnaphthyl)-N-tert-butoxycarbonyl-6-amino-8a-indolizidine methyl esterEscherichia coli-dissociation constant: 0.077 mM652727 2D-image
(6R,8aR)-6-benzyl-6-N-tert-butoxycarbonylamino-8a-carboxyindolizidin-5-one methyl esterEscherichia coli-dissociation constant: 0.14 mM652727 2D-image
(6R,8aR)-6-benzyl-N-benzyloxycarbonyl-6-amino-8a-carboxyindolizidin-5-one methyl esterEscherichia coli-dissociation constant: 0.124 mM652727 2D-image
(6R,8aR)-6-N-tert-butoxycarbonylamino-8a-carboxyindolizidine methyl esterEscherichia coli-dissociation constant: 0.2 mM652727 2D-image
(6S,8aR)-6-N-tert-butoxycarbonylamino-8a-carboxyindolizidine methyl esterEscherichia coli-dissociation constant: above 0.2 mM652727 2D-image
(E)-2-(2-hydroxy-2-isobutylethy 1idene)-1-meth ylcyclopentane-(L)-tyrosylcarboxamideHomo sapiens--681701 2D-image
1-(1H-imidazol-2-ylthio)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678742 2D-image
1-(2-phenylethyl)-4-pyridin-3-ylbutyl (2R)-1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylateHomo sapiens--682235 2D-image
1-(3-hydroxyphenoxy)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678716 2D-image
1-(phenylthio)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678716 2D-image
1-(pyridin-3-ylthio)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678742 2D-image
1-(pyridin-4-ylthio)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678716 2D-image
1-benzyl-2-pyridin-3-ylethyl 1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]-D-prolinateHomo sapiens--682235 2D-image
1-benzyl-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
1-phenyl-3-pyridin-3-ylpropyl (2R)-1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylateHomo sapiens--682235 2D-image
1-[(1R,10S)-3,8-dioxa-14-azabicyclo[8.3.1]tetradec-14-yl]-3,3-dimethyl-1-oxopentan-2-oneHomo sapiensP62942-678718 2D-image
15,15-dimethyltetradecahydropyrido[2,1-c][1,9,4]dioxazacyclononadecine-1,12,16,17(3H,19H)-tetroneHomo sapiens--678714 2D-image
2,7-dimethylbenzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetroneMus musculus-IC50: 0.002 mM650816 2D-image
2-(4-((2R)-2-[(1R,3R,5R)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl)-2,6-dioxopiperidin-1-yl)acetamideHomo sapiens-competitive inhibition. Evaluation of cytotoxicity against cell lines L-929 fibroblasts and K-562 leukemic cells681273 2D-image
2-oxo-2-[(1R,10S)-5-phenoxy-3,8-dioxa-14-azabicyclo[8.3.1]tetradec-14-yl]-1-(3,4,5-trimethoxyphenyl)ethanoneHomo sapiensP62942-678718 2D-image
2-[(1R,10S)-3,8-dioxa-14-azabicyclo[8.3.1]tetradec-14-yl]-2-oxo-1-(3,4,5-trimethoxyphenyl)ethanoneHomo sapiensP62942-678718 2D-image
3,5-dichloro-N-(3-[(2-naphthylacetyl)amino]phenyl)benzamideHomo sapiens--681275 2D-image
3,5-dichloro-N-[3-([[(2,4-dibromophenyl)amino]carbonyl]amino)phenyl]benzamideHomo sapiens--681275 2D-image
3,5-dichloro-N-[3-([[(3,5-dichlorophenyl)amino]carbonyl]amino)phenyl]benzamideHomo sapiens--681275 2D-image
3,5-dichloro-N-[3-[(3,3-diphenylpropanoyl)amino]phenyl]benzamideHomo sapiens--681275 2D-image
3,5-dichloro-N-[3-[([[4-(trifluoromethyl)phenyl]amino]carbonyl)amino]phenyl]benzamideHomo sapiens--681275 2D-image
3-(3,4,5-trimethoxyphenyl)propyl (2R)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--680340 2D-image
3-(3,4,5-trimethoxyphenyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
3-(3,4,5-trimethoxyphenyl)propyl 1-(benzylsulfonyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
3-phenyl-1-(2-pyridin-3-ylethyl)propyl 1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]-D-prolinateHomo sapiens--682235 2D-image
3-phenylpropyl 1-(2-hydroxy-3,3-dimethylpentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
4-phenyl-1-(2-pyridin-3-ylethyl)butyl (2R)-1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylateHomo sapiens--682235 2D-image
4-phenyl-1-(3-pyridin-3-ylpropyl)butyl (2R)-1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylateHomo sapiens--682235 2D-image
4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperidinedioneHomo sapiens-competitive inhibition. Evaluation of cytotoxicity against cell lines L-929 fibroblasts and K-562 leukemic cells681273 2D-image
4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione-1-(4-ethyl butanoate)Homo sapiens-competitive inhibition. Evaluation of cytotoxicity against cell lines L-929 fibroblasts and K-562 leukemic cells681273 2D-image
4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione-1-(ethyl ethanoate)Homo sapiens-competitive inhibition. Evaluation of cytotoxicity against cell lines L-929 fibroblasts and K-562 leukemic cells. Compound is able to significantly speed nerve regeneration in a rat sciatic nerve neurotomy model681273 2D-image
5-hydroxy-1,4-naphthoquinoneEscherichia coli-i.e. juglone, 0.0057 mM, complete inhibition of wild-type and mutant C69A within 30 min, irreversible inhibition of the parvulin family of peptidyl-prolyl cis/trans isomerases, specific inhibition allows selective inactivation of these enzymes in presence of other peptidylprolyl isomerases, the inactivated parvulin contains two juglone molecules that are covalently bound to the side chains of Cys41 and Cys69, partial unfolding of the active site of the parvulins is thought to be the cause of the deterioration of peptidylprolyl isomerase activity649847 2D-image
5-hydroxy-1,4-naphthoquinoneHomo sapiens, Saccharomyces cerevisiae-i.e. juglone, 0.0057 mM, complete inactivation within 150 min, irreversible inhibition of the parvulin family of peptidyl-prolyl cis/trans isomerases, specific inhibition allows selective inactivation of these enzymes in presence of other peptidylprolyl isomerases, the inactivated parvulin contains two juglone molecules that are covalently bound to the side chains of Cys41 and Cys69, partial unfolding of the active site of the parvulins is thought to be the cause of the deterioration of peptidylprolyl isomerase activity649847 2D-image
5-methoxy-1',3'dihydro-3H-spiro[1-benzofuran-2,2'-indene]-3-oneHomo sapiens--694290 2D-image
5-methoxy-2',3'-dihydro-3H-spiro[1-benzofuran-2,1'-indene]-3-oneHomo sapiens--694290 2D-image
5-methoxy-3H-spiro[1-benzofuran-2,1'-cyclopent[3]en]-3-oneHomo sapiens--694290 2D-image
Ac-Ala-GlyPSI(PO2Et-N)Pro-Phe-4-nitroanilideHomo sapiens-transition-state analogue of peptidylprolyl isomerase activity of cyclophilin Cyp-18, Kd value 0.127 mM681274 2D-image
Ac-beta-(3-benzothienyl)Ala-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens--681281 2D-image
Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-(t-butyl)Phe-Thr(PO3H2)-(methyl)Ala-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens--681281 2D-image
Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-(t-butyl)Phe-Thr(PO3H2)-Yaa-Zaa-Gln-NH2Homo sapiens--681281 2D-image
Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-beta-(2-thienyl)Ala-Thr(PO3H2)-(methyl)Ala-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens--681281 2D-image
Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-beta-(3-benzothienyl)Ala-D-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens--681281 2D-image
Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-beta-(3-benzothienyl)Ala-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens--681281 2D-image
Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-beta-cyclohexylAla-Thr(PO3H2)-(methyl)Ala-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens--681281 2D-image
Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-Phe-D-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens--681281 2D-image
Ac-Phe-D-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens--681281 2D-image
Ac-Phe-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens--681281 2D-image
acetyl-Ala-Ala-D-Ser(PO3H2)-Pro-Leu-NH-4-nitroanilideHomo sapiens-IC50: 0.001 mM650106 2D-image
acetyl-Ala-Ala-D-Ser-Pro-Leu-NH-4-nitroanilideHomo sapiens-IC50: 0.085 mM650106 2D-image
acetyl-Ala-Pro-Phe-4-(trimethylammonium)anilideHomo sapiens-IC50: 7 mM651287 2D-image
acetyl-Ala-Pro-Phe-4-nitroanilideHomo sapiens-IC50: 0.77 mM651287 2D-image
Ala-ProHomo sapiens--650106 2D-image
Ala-ProHomo sapiens-IC50: 30 mM651287 2D-image
alpha-LactalbuminMycoplasma genitalium-unfolded652779-
aryl1-indanyl ketonesHomo sapiens-reversible inhibition of Pin1704154-
ATPOryctolagus cuniculus, Saccharomyces cerevisiae-at least 3fold stimulation, excess of ATP over Mg2+ is inhibitory662459 2D-image
benzyl (2S)-1-[[(1S,2R,5R)-1-hydroxy-5-[(1R)-1-methoxy-3-methylbut-2-en-1-yl]-2-methylcyclohexyl](oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678717 2D-image
benzyl (2S)-1-[[(1S,2R,5R)-1-hydroxy-5-[(1S)-1-methoxy-3-methylbutyl]-2-methylcyclohexyl](oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678717 2D-image
benzyl (2S)-1-[[(1S,2R,5R)-1-hydroxy-5-[(1S)-1-methoxyethyl]-2-methylcyclohexyl](oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678717 2D-image
Cu2+Sus scrofa--2507, 2511 2D-image
cyclic CRYPEVEICHomo sapiens-the cyclic peptide is specific for the active site of the PPIase domain715863-
cyclo(Arg-Arg-Arg-D-pThr-Pip-Nal-Arg-Arg-Gln)Homo sapiens--705066-
cyclo(Arg-Arg-Arg-D-Thr-Pip-Nal-Arg-Arg-Gln)Homo sapiens--705066-
cyclo(D-Ala-Gln-Glu-Mpa-Mal-Ile-Gln)Homo sapiens--705066-
cyclo(D-Ala-Gly-D-pThr-Pip-Nal-Orn-Gln)Homo sapiens--705066-
cyclo(D-Ala-Ile-D-pSer-Pro-Nal-Orn-Gln)Homo sapiens--705066-
cyclo(D-Ala-Sar-D-pThr-Pip-Nal-Tyr-Gln)Homo sapiens--705066-
cyclo(D-Ala-Sar-D-pThr-Pip-Nal-Tyr-Gln)-Lys-SHHomo sapiens--705066-
cyclo(D-Arg-D-Arg-D-pThr-Pip-Nal-Arg-D-Arg-D-Arg-D-Arg-Gln)Homo sapiens--705066-
cyclo(D-Arg-D-Arg-D-pThr-Pip-Nal-Arg-Gln)Homo sapiens--705066-
cyclo(D-Arg-D-Arg-D-Thr-Pip-Nal-Arg-D-Arg-D-Arg-D-Arg-Gln)Homo sapiens--705066-
cyclo(D-Arg-D-Arg-D-Thr-Pip-Nal-Arg-Gln)Homo sapiens--705066-
CycloheximideHomo sapiens--681273 2D-image
cyclolinopeptide ABos taurus-interaction with several synthetic analogues cyclolinopeptide A651755 2D-image
cyclosporin ASus scrofa--2510, 2515, 653787 2D-image
cyclosporin ANeurospora crassa--2514 2D-image
cyclosporin AHomo sapiens--2519, 2527, 2530, 691452 2D-image
cyclosporin ASaccharomyces cerevisiae--2521, 2524 2D-image
cyclosporin AGallus gallus--2522 2D-image
cyclosporin AHomo sapiens-the combination of cyclosporin A or its analogues with other drugs, such as nucleotide analogues, e.g. 3'-azido-3'-deoxy-thymidine, or 2',3'-dideoxycytidine, HIV-1-protease inhibitors, and antibiotics, might provide long-term benefit to HIV-1-infected individuals2523 2D-image
cyclosporin AMethanothermococcus thermolithotrophicusO52980no inhibition by cyclosporins2525 2D-image
cyclosporin ALegionella pneumophila--2527 2D-image
cyclosporin AHomo sapiens-the sequence MeLeu9-trans-MeLeu10-MeVal is responsible for the efficient binding in the active site of cyclophilin. The cis-conformer is inactive as inhibitor2529 2D-image
cyclosporin AHomo sapiens-and analogs2531 2D-image
cyclosporin AEscherichia coli--2533 2D-image
cyclosporin APlasmodium falciparum--2534 2D-image
cyclosporin AZea mays-inhibits cytosolic and microsomal enzyme form2535 2D-image
cyclosporin ARattus norvegicus--2537 2D-image
cyclosporin AEscherichia coli-no inhibition2538, 2554 2D-image
cyclosporin APlasmodium falciparum-and analogs2555 2D-image
cyclosporin ASpinacia oleraceaP82536-651323 2D-image
cyclosporin ABos taurus--651755 2D-image
cyclosporin APisum sativum-inhibits the activity largely localized to the mitochondrial matrix651842 2D-image
cyclosporin ACaenorhabditis elegans-IC50: 16 nM651964 2D-image
cyclosporin ACaenorhabditis elegansP52014IC50: 50 nM652894 2D-image
cyclosporin AVicia faba--653459 2D-image
cyclosporin ABrassica napus, Solanum lycopersicum, Zea mays--653605 2D-image
cyclosporin AHaemonchus contortusQ4G338-663015 2D-image
cyclosporin ASchistosoma mansoniQ26548-680801 2D-image
cyclosporin AOryctolagus cuniculusQ9TTC6and cyclosporin derivative with modifications in the D-Ser side chain. Inhibition leads to failure of polymerization of the extracellular multi-domain protein hensin, plus the loss of the apical cytoskeleton, apical microvilli, and the columnar epithelial shape of clone C cells693250 2D-image
cyclosporin ARicinus communisQ8VX73almost complete inhibition694779 2D-image
cyclosporin AHaemaphysalis longicornisB2ZWT4, B2ZWT5; 694932 2D-image
cyclosporin AHomo sapiens-forms an inhibitory complex with cyclophilin. CyPA is a major intracellular target of cyclosporines705430 2D-image
cyclosporin AArabidopsis thalianaQ9SCY2-706176 2D-image
D-Ser(PO3H2)-ProHomo sapiens-1 mM, 20% inhibition650106 2D-image
diethyl-1,3,6,10-tetrahydro-1,3,6,10-tetraoxoanthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-2,9-diacetateHomo sapiens, Rattus norvegicus--704154-
diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn] phenathroline-2,7-diacetateHomo sapiens, Rattus norvegicus--704154-
diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline 2,7-diacetateMus musculus-IC50: 0.0015 mM, inhibitor with the least non-specific toxicity650816 2D-image
diethyl-1,3,8,10-tetrahydro-1,3,8,10-tetraoxoanthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-2,9-diacetateMus musculus-IC50: 0.0015 mM650816 2D-image
dipenramethylene thiuram monosulfideHomo sapiens, Rattus norvegicus--704154-
ethyl (2S)-1-(4,4-dimethyl-2-oxohexanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
ethyl (2S)-1-[(2-methoxycyclohexyl)(oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678713 2D-image
ethyl (2S)-1-[cyclohexyl(oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678713 2D-image
ethyl 1-(4,4-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
ethyl 1-(4-methyl-2-oxopentanethioyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
ethyl 1-(4-methyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
ethyl 1-(5-ethoxy-4,4-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
ethyl 1-[(1-methoxycyclohexyl)(oxo)acetyl]pyrrolidine-2-carboxylateHomo sapiens--678713 2D-image
ethyl 1-[(3-methoxytetrahydro-2H-pyran-2-yl)(oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678713 2D-image
FK506Gallus gallus-only one of the 4 domains can be inhibited by the immunosuppressive drug2522 2D-image
FK506Methanothermococcus thermolithotrophicusO52980; IC50: 250 nM2525 2D-image
FK506Zea mays-IC50: 110 nM653563 2D-image
FK506Plasmodium falciparum-50% inhibition at 0.00032 mM662803 2D-image
FK506Escherichia coli--715653 2D-image
GPI-1046Rattus norvegicus, Xenopus laevisO42123-705910-
Hg2+Sus scrofa--2511 2D-image
jugloneRattus norvegicusB0BNL2pharmacological inhibitor of isoform Pin1, application of juglone partially prevents dephosphorylation of phosphoptotein Tau at Thr231680665 2D-image
jugloneHomo sapiens-Pin1 inhibition leads to relocalization of endogenous c-Rel to the cytoplasm coincident with lymphoma cell death and/or growth inhibition703021 2D-image
jugloneHomo sapiens, Rattus norvegicus-i.e. 5-hydroxy-1,4-naphthalenedione, from leaves, roots, and bark of plants of family Juglandaceae. The compound causes a partial unfolding of the PPIase active site704154 2D-image
jugloneHomo sapiens-i.e. 5-hydroxy-1,4-naphthoquinone, selective and irreversible inhibition. Juglone reduces PPIase activity but does not alter Pin1 expression705854 2D-image
jugloneHomo sapiens-i.e. 5-hydroxy-1,4-naphthoquinone, natural inhibitor of Pin1716069 2D-image
lactalbuminBacillus subtilis-reduced and carboxymethylated, strong inhibition by the permanently unfolded protein649837-
linear CRYPEVEICHomo sapiens--715863-
N,N''-(4,6-dibromo-1,3-phenylene)bis[3-(4-iodophenyl)urea]Homo sapiens--681275 2D-image
N,N'-1,3-phenylenebis(3,5-dichlorobenzamide)Homo sapiens--681275 2D-image
NEMZea mays-cytosolic enzyme form2535 2D-image
non-folding vartiant of ribonuclease T1Mycoplasma genitalium-that lacks Pro39652779-
PCMBSus scrofa--2511 2D-image
Phe-Ser(PO3H2)-PSI[CS-N]-Pro-Phe-NH-4-nitroanilideHomo sapiens-IC50: 0.004 mM650106 2D-image
Phe-Ser-PSI[CS-N]-Pro-Phe-NH-4-nitroanilideHomo sapiens-IC50: 0.097 mM650106 2D-image
PhenylglyoxalZea mays-cytosolic enzyme form2535 2D-image
QAEGPKHomo sapiensQ96BP3peptide corresponding to peptide QAEGP487KR at the N-terminus of the enzyme's isomerase domain. Peptide binds to the active site, but the enzyme does not catalyze its isomerization692291 2D-image
RapamycinPisum sativum-inhibits the activity associated with the mitochondrial membranes651842 2D-image
RapamycinPlasmodium falciparum-50% inhibition at 0.00048 mM662803 2D-image
RapamycinNeisseria gonorrhoeae-50% inhibition at 5 nM662909 2D-image
RNase T1Bacillus subtilis-reduced and carboxymethylated form of the P39A variant, strong inhibition by the permanently unfolded protein649837-
SDSSus scrofa--2511 2D-image
Ser(PO3H2)-ProHomo sapiens-; IC50: 2.0 mM650106 2D-image
Ser-ProHomo sapiens--650106-
Ser-PSI[CS-N]-ProHomo sapiens--650106 2D-image
Suc-Ala-Ala-Pro-Phe-4-nitroanilideHomo sapiens-transition-state analogue of peptidylprolyl isomerase activity of cyclophilin Cyp-18, Kd value 0.138 mM681274 2D-image
Suc-Ala-GlyPSI(PO2Et-N)Pro-Phe-4-nitroanilideHomo sapiens-transition-state analogue of peptidylprolyl isomerase activity of cyclophilin Cyp-18, Kd value 0.02 mM. Selectively inhibits Cyp-18, but not enzyme isoform FKBP12681274 2D-image
succinyl-Ala-Ala-Pro-NH2Homo sapiens-IC50: 14 mM651287 2D-image
succinyl-Ala-Ala-Pro-Phe-4-carboxymethylanilideHomo sapiens-IC50: 4.4 mM651287 2D-image
succinyl-Ala-Ala-Pro-Phe-4-nitroanilideHomo sapiens-IC50: 0.54 mM651287 2D-image
succinyl-Ala-Pro-Phe-4-aminoanilideHomo sapiens-IC50: 5.8 mM651287 2D-image
succinyl-Ala-Pro-Phe-4-carboxmethylanilideHomo sapiens-IC50: 0.7 mM651287 2D-image
succinyl-Ala-Pro-Phe-4-nitroanilideHomo sapiens-IC50: 0.17 mM651287 2D-image
succinyl-Pro-Phe-4-nitroanilideHomo sapiens-IC50: 1.09 mM651287 2D-image
[(1S,2R,3S,6R,7aR)-2-(benzylcarbamoyl)-6-methoxy-3-naphthalen-2-ylhexahydro-1H-pyrrolizin-1-yl]methyl dihydrogen phosphateHomo sapiens--680060 2D-image
[(1S,2R,3S,6S,7aR)-2-(benzylcarbamoyl)-6-fluoro-3-naphthalen-2-ylhexahydro-1H-pyrrolizin-1-yl]methyl dihydrogen phosphateHomo sapiens--680060 2D-image
[(1S,2R,3S,7aR)-2-(benzylcarbamoyl)-3-(pentafluorophenyl)hexahydro-1H-pyrrolizin-1-yl]methyl dihydrogen phosphateHomo sapiens--680060 2D-image
[(1S,2R,3S,7aR)-2-(benzylcarbamoyl)-3-naphthalen-2-ylhexahydro-1H-pyrrolizin-1-yl]methyl dihydrogen phosphateHomo sapiens--680060 2D-image
[(1S,2R,3S,7aR)-2-(benzylcarbamoyl)-3-phenylhexahydro-1H-pyrrolizin-1-yl]methyl dihydrogen phosphateHomo sapiens--680060 2D-image
[(1S,2R,3S,7aR)-2-[(1,3-benzodioxol-5-ylmethyl)carbamoyl]-3-naphthalen-2-ylhexahydro-1H-pyrrolizin-1-yl]methyl dihydrogen phosphateHomo sapiens--680060 2D-image
methyl N-([(1R,2E)-2-[(2S)-2-hydroxy-4-methylpentylidene]-1-methylcyclopentyl]carbonyl)-L-tyrosinateHomo sapiens--678742 2D-image
additional informationSus scrofa-no inhibition: chlorotosylamidophenylbutane, diisopropylphosphorofluoridate2511-
additional informationMethanothermococcus thermolithotrophicusO52980no inhibition by cyclosporine, even at 0.01 mM2525-
additional informationMus musculus-Pin1 inhibitors may be used as a novel type of anticancer drug that acts by blocking cell cycle progression650816-
additional informationSpinacia oleraceaP82536no inhibition by FK506651323-
additional informationCaenorhabditis elegansQ7KFC0no inhibition by cyclosporin A even at 0.005 mM652239-
additional informationOnchocerca volvulusQ8IA80no inhibition by cyclosporin A even at 0.005 mM652239-
additional informationPlasmodium falciparum-cyclosporin A is not inhibitory up to 0.005 mM662803-
additional informationHaemonchus contortusQ4G338not inhibitory: FK506663015-
additional informationRicinus communisQ8VX73not inhibitory: FK506694779-
additional informationHomo sapiens-the OBOC peptide library screening for and selection of selected inhibitors containing a consensus motif of D-pThr-L-piperidine-2-carboxylic acid-L-2-naphthylalanine using inactive enzyme mutant S16A/Y23A, interaction analysis by Isothermal titration calorimetry, overview. A second generation of cell permeable Pin1 inhibitors, that have have antiproliferative activity against the cancer cells, is designed by replacing the noncritical residues within the cyclic peptide ring with arginine residues. Effects of inhibitor peptides in vivo on cancer cells, e.g. HeLa cells, overview705066-
additional informationHomo sapiens, Rattus norvegicus-inhibition of Pin1 inhibits okadaic acid-induced aberrant perikaryal phosphorylation of NF, and inhibition of Pin1 inhibits the okadaic acid- or Fos-induced neuronal apoptosis705286-

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
ATPHomo sapiens-stimulation662459 2D-image
ATPOryctolagus cuniculus-at least 3fold stimulation, excess of ATP over Mg2+ is inhibitory662459 2D-image
ATPSaccharomyces cerevisiae-at least 3fold stimulation, excess of ATP over Mg2+ is inhibitory; stimulation662459 2D-image
equine chorionic gonadotropinMus musculusQ9QUR7significant increase in expression of isoform Pin1 mRNA, application of human chorionic gonadotropin attenuates this increase. mRNA expression of E2F transcription factor, which controls the expression of Pin1, is decreased in the ovaries after treatment with equine chorionic gonadotropin. Protein level of Pin1 shows the same tendencies as the expression of RNA681633-
additional informationHomo sapiens-GM-CSF-induced activation of Erk1/2, which phosphorylated Thr167 of the pro-apoptotic Bcl-2-associated X protein, Bax, facilitates de novo interaction of Bax with the prolyl isomerase Pin1705854-

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.17-N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilideHomo sapiens-mutant R68A/R69A, 0°C, pH 7.5681404 2D-image
0.31-N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilideHomo sapiens-wild-type, 0°C, pH 7.5681404 2D-image
0.37-N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilideHomo sapiens-mutant C113D, 0°C, pH 7.5681404 2D-image
0.41-N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilideHomo sapiens-mutant C113S, 0°C, pH 7.5681404 2D-image
0.00045-RNase T1Bacillus subtilis-trigger factor649837-
0.451-succinyl-Ala-Ala-Pro-Phe 4-nitroanilideLegionella pneumophila--2527 2D-image
1.247-succinyl-Ala-Ala-Pro-Phe 4-nitroanilideHomo sapiens--2527 2D-image
0.12-succinyl-Ala-Glu-Pro-Phe-7-amido-4-methylcoumarinMus musculus--650816 2D-image
0.585-succinyl-Ala-Lys-Pro-Phe 4-nitroanilideHomo sapiens--2527 2D-image
0.788-succinyl-Ala-Lys-Pro-Phe 4-nitroanilideLegionella pneumophila--2527 2D-image
0.53-Ala-Gly-PSI[CS-N]-Pro-Phe 4-nitroanilideHomo sapiens--2518 2D-image
additional information-additional informationLupinus luteusO49886ratio of kcat/Km is 4600000 per s and M at 15°C, pH 7.8694993-
0.7-N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilideHomo sapiens-mutant K63A, 0°C, pH 7.5681404 2D-image
additional information-RNase T1Bordetella pertussisP40415ratio kcat/Km value of 43 per mM and s, pH 6.6693627-
0.00065-RNase T1Mycoplasma genitalium-disulfide-reduced and S-carboxymethylated form of a variant of Rnase T1 with Ser54Gly and Pro55Asn652779-
additional information-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilideRicinus communisQ8VX73specificity constant kcat/Km for (His)6-RcCYP1 is 9.48 per microM and s694779 2D-image
additional information-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilideHaemaphysalis longicornisB2ZWT4, B2ZWT5kcat/Km ratio is 14.1 per mM and s; kcat/Km ratio is 21 per mM and s694932 2D-image

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
3.7-N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilideHomo sapiens-mutant C113S, 0°C, pH 7.5681404 2D-image
11-N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilideHomo sapiens-mutant K63A, 0°C, pH 7.5681404 2D-image
18-N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilideHomo sapiens-mutant R68A/R69A, 0°C, pH 7.5681404 2D-image
29-N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilideHomo sapiens-mutant C113D, 0°C, pH 7.5681404 2D-image
140-N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilideHomo sapiens-wild-type, 0°C, pH 7.5681404 2D-image
0.45-RNase T1Mycoplasma genitalium-disulfide-reduced and S-carboxymethylated form of a variant of Rnase T1 with Ser54Gly and Pro55Asn652779-
0.006-succinyl-Ala-Ala-(cis)-Pro-Lys 4-methylcoumarin 7-amideOryctolagus cuniculus-20°C, pH 7.4, mutant DELTA208-213662459 2D-image
0.008-succinyl-Ala-Ala-(cis)-Pro-Lys 4-methylcoumarin 7-amideOryctolagus cuniculus-20°C, pH 7.4, mutant DELTA208-213, presence of 1 mM MgATP662459 2D-image
0.011-succinyl-Ala-Ala-(cis)-Pro-Lys 4-methylcoumarin 7-amideSaccharomyces cerevisiae-20°C, pH 7.4, mutant D205G of Ypa1662459 2D-image
0.016-succinyl-Ala-Ala-(cis)-Pro-Lys 4-methylcoumarin 7-amideSaccharomyces cerevisiae-20°C, pH 7.4, mutant D205G of Ypa1, presence of 1 mM MgATP662459 2D-image
0.03-succinyl-Ala-Ala-(cis)-Pro-Lys 4-methylcoumarin 7-amideOryctolagus cuniculus-20°C, pH 7.4, wild-type662459 2D-image
0.03-succinyl-Ala-Ala-(cis)-Pro-Lys 4-methylcoumarin 7-amideSaccharomyces cerevisiae-20°C, pH 7.4, wild-type Ypa2662459 2D-image
0.05-succinyl-Ala-Ala-(cis)-Pro-Lys 4-methylcoumarin 7-amideSaccharomyces cerevisiae-20°C, pH 7.4, wild-type Ypa2, presence of 1 mM MgATP662459 2D-image
0.1-succinyl-Ala-Ala-(cis)-Pro-Lys 4-methylcoumarin 7-amideOryctolagus cuniculus-20°C, pH 7.4, wild-type, presence of 1 mM MgATP662459 2D-image
0.02-Succinyl-Ala-Ala-(cis)-Pro-Phe 4-methylcoumarin 7-amideSaccharomyces cerevisiae-20°C, pH 7.4, wild-type Ypa1662459 2D-image
0.03-Succinyl-Ala-Ala-(cis)-Pro-Phe 4-methylcoumarin 7-amideOryctolagus cuniculus-20°C, pH 7.4, wild-type662459 2D-image
0.07-Succinyl-Ala-Ala-(cis)-Pro-Phe 4-methylcoumarin 7-amideSaccharomyces cerevisiae-20°C, pH 7.4, wild-type Ypa1, presence of 1 mM MgATP662459 2D-image
0.19-Succinyl-Ala-Ala-(cis)-Pro-Phe 4-methylcoumarin 7-amideOryctolagus cuniculus-20°C, pH 7.4, wild-type, presence of 1 mM MgATP662459 2D-image
1480-succinyl-Ala-Ala-Pro-Phe 4-nitroanilideHomo sapiens--2527 2D-image
1820-succinyl-Ala-Ala-Pro-Phe 4-nitroanilideLegionella pneumophila--2527 2D-image
14600-succinyl-Ala-Ala-Pro-Phe 4-nitroanilideHomo sapiens--2527 2D-image
1060-succinyl-Ala-Lys-Pro-Phe 4-nitroanilideLegionella pneumophila--2527 2D-image
additional information-additional informationGallus gallus--2522-
additional information-additional informationMycobacterium tuberculosisP65762ratio of kcat/Km-value is 2,000,000 per M and s661643-
additional information-additional informationNeisseria gonorrhoeae-ratio of kcat/Km-value is 410000 per M and s662909-

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
5.11-4-aminobenzoyl-Cys-Lys-(trans)-Pro-Ala-Cys-(NO2)-Tyr-NH2Escherichia coli-mutant enzyme, with 50 mM dithiothreitol in 35 mM HEPES, pH 7.8, at 10°C7156530
115-4-aminobenzoyl-Cys-Lys-(trans)-Pro-Ala-Cys-(NO2)-Tyr-NH2Escherichia coli-wild type enzyme, with 50 mM dithiothreitol in 35 mM HEPES, pH 7.8, at 10°C7156530
96.9-4-aminobenzoyl-Cys-Lys-(trans)-Pro-Gly-Cys-(NO2)-Tyr-NH2Escherichia coli-wild type enzyme, with 50 mM dithiothreitol in 35 mM HEPES, pH 7.8, at 10°C7156530
3.45-4-aminobenzoyl-Cys-Phe-(trans)-Pro-Val-Cys-(NO2)-Tyr-NH2Escherichia coli-mutant enzyme G148D, with 50 mM dithiothreitol in 35 mM HEPES, pH 7.8, at 10°C7156530
1380-4-aminobenzoyl-Cys-Phe-(trans)-Pro-Val-Cys-(NO2)-Tyr-NH2Escherichia coli-wild type enzyme, with 50 mM dithiothreitol in 35 mM HEPES, pH 7.8, at 10°C7156530
6.7-N-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilideTrypanosoma cruziB8XP93at 10 °C in 35 mM sodium HEPES buffer, pH 7.8714320211029
97.1-N-succinyl-Ala-Arg-(cis)-Pro-Phe-4-nitroanilideTrypanosoma cruziB8XP93at 10 °C in 35 mM sodium HEPES buffer, pH 7.87143200
7.4-N-succinyl-Ala-Glu-(cis)-Pro-Phe-4-nitroanilideTrypanosoma cruziB8XP93at 10 °C in 35 mM sodium HEPES buffer, pH 7.8714320255859
25.9-N-succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilideTrypanosoma cruziB8XP93at 10 °C in 35 mM sodium HEPES buffer, pH 7.8714320211028
4.2-N-succinyl-Ala-Phe-(cis)-Pro-Phe-4-nitroanilideTrypanosoma cruziB8XP93at 10 °C in 35 mM sodium HEPES buffer, pH 7.8714320211030

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
1e-05-(1R)-1,3-diphenyl-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylateHomo sapiens--680340 2D-image
0.01-(1R)-1,3-diphenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.007-(1R)-1-cyclohexyl-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.0040.01(1R)-1-naphthalen-2-yl-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.009-(1R)-1-phenyl-3-(3,4,5-trimethoxyphenyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
5e-06-(1R)-1-[3-(diethenylcarbamoyl)phenyl]-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678715 2D-image
0.009-(1R)-3-(1,3-benzodioxol-5-yl)-1-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.0020.006(1R)-3-(3,4-dimethoxyphenyl)-1-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.01-(1R)-3-cyclohexyl-1-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.02-(1R)-3-cyclohexyl-1-phenylpropyl 1-[cyclohexyl(oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678713 2D-image
5e-06-(1R)-3-phenyl-1-[3-(phenylcarbonyl)phenyl]propyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678715 2D-image
0.00016-(1S)-1,3-diphenylpropyl 1-(benzylsulfonyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
7e-06-(1S)-1-cyclohexyl-3-phenylpropyl (2R)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--680340 2D-image
0.0002-(1S)-1-phenyl-3-(3,4,5-trimethoxyphenyl)propyl 1-(3,3-dimethylbutanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.0001-(24aS)-17,17-dimethylhexadecahydropyrido[2,1-c][1,9,4]dioxazacyclohenicosine-1,14,18,19(3H,21)-tetroneHomo sapiens--680340 2D-image
1e-06-(3S,26aR)-19,19-dimethyl-3-(2-phenylethyl)-12,13,14,15,18,19,24,25,26,26a-decahydro-3H,10H-4,8-(metheno)pyrido[2,1-c][1,9,17,4]trioxazacyclotricosine-1,16,20,21(11H,23H)-tetroneHomo sapiens--680340 2D-image
0.0086-(E)-2-(2-hydroxy-2-isobutylethy 1idene)-1-meth ylcyclopentane-(L)-tyrosylcarboxamideHomo sapiens-0°C, pH 8.0681701 2D-image
5e-05-1-(2-phenylethyl)-4-pyridin-3-ylbutyl (2R)-1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylateHomo sapiens--682235 2D-image
0.0167-1-(3-hydroxyphenoxy)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678716 2D-image
0.0092-1-(phenylthio)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678716 2D-image
0.0079-1-(pyridin-4-ylthio)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678716 2D-image
8.4e-05-1-benzyl-2-pyridin-3-ylethyl 1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]-D-prolinateHomo sapiens--682235 2D-image
0.055-1-benzyl-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
5.9e-05-1-phenyl-3-pyridin-3-ylpropyl (2R)-1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylateHomo sapiens--682235 2D-image
0.0083-1-[(1R,10S)-3,8-dioxa-14-azabicyclo[8.3.1]tetradec-14-yl]-3,3-dimethyl-1-oxopentan-2-oneHomo sapiensP62942pH 8.0678718 2D-image
0.03-15,15-dimethyltetradecahydropyrido[2,1-c][1,9,4]dioxazacyclononadecine-1,12,16,17(3H,19H)-tetroneHomo sapiens--678714 2D-image
0.0012-2-oxo-2-[(1R,10S)-5-phenoxy-3,8-dioxa-14-azabicyclo[8.3.1]tetradec-14-yl]-1-(3,4,5-trimethoxyphenyl)ethanoneHomo sapiensP62942pH 8.0678718 2D-image
0.0081-2-[(1R,10S)-3,8-dioxa-14-azabicyclo[8.3.1]tetradec-14-yl]-2-oxo-1-(3,4,5-trimethoxyphenyl)ethanoneHomo sapiensP62942pH 8.0678718 2D-image
1.2e-05-3-(3,4,5-trimethoxyphenyl)propyl (2R)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--680340 2D-image
0.012-3-(3,4,5-trimethoxyphenyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.00023-3-(3,4,5-trimethoxyphenyl)propyl 1-(benzylsulfonyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
6e-05-3-phenyl-1-(2-pyridin-3-ylethyl)propyl 1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]-D-prolinateHomo sapiens--682235 2D-image
0.0023-3-phenylpropyl 1-(2-hydroxy-3,3-dimethylpentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
9e-05-4-phenyl-1-(2-pyridin-3-ylethyl)butyl (2R)-1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylateHomo sapiens--682235 2D-image
1.9e-05-4-phenyl-1-(3-pyridin-3-ylpropyl)butyl (2R)-1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylateHomo sapiens--682235 2D-image
5.59e-05-5-hydroxy-1,4-naphthoquinoneEscherichia coli-mutant enzyme C69A649847 2D-image
0.258-Ac-beta-(3-benzothienyl)Ala-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens-pH 7.8, 10°C681281 2D-image
0.0012-Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-beta-(3-benzothienyl)Ala-D-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens-pH 7.8, 10°C681281 2D-image
0.183-Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-beta-(3-benzothienyl)Ala-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens-pH 7.8, 10°C681281 2D-image
0.0048-Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-Phe-D-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens-pH 7.8, 10°C681281 2D-image
0.0183-Ac-Phe-D-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens-pH 7.8, 10°C681281 2D-image
0.547-Ac-Phe-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens-pH 7.8, 10°C681281 2D-image
19-Ala-ProHomo sapiens--650106 2D-image
5e-05-alpha-LactalbuminMycoplasma genitalium-unfolded alpha-lactalbumin652779-
6.8e-05-benzyl (2S)-1-[[(1S,2R,5R)-1-hydroxy-5-[(1R)-1-methoxy-3-methylbut-2-en-1-yl]-2-methylcyclohexyl](oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678717 2D-image
2.8e-06-benzyl (2S)-1-[[(1S,2R,5R)-1-hydroxy-5-[(1S)-1-methoxy-3-methylbutyl]-2-methylcyclohexyl](oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678717 2D-image
8.1e-05-benzyl (2S)-1-[[(1S,2R,5R)-1-hydroxy-5-[(1S)-1-methoxyethyl]-2-methylcyclohexyl](oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678717 2D-image
0.0002-cyclic CRYPEVEICHomo sapiens-using Trp-Phe-Tyr-pSer-Pro-Arg-4-nitroanilide as substrate, in 50 mM HEPES, 0.1 M NaCl, 5 mM NaN3, pH 7.4, at 22°C715863-
0.00052-cyclic CRYPEVEICHomo sapiens-using succinyl-Ala-Glu-(cis)-Pro-Phe-4-nitroanilide as substrate, in 50 mM HEPES, 0.1 M NaCl, 5 mM NaN3, pH 7.4, at 22°C715863-
0.0034-CycloheximideHomo sapiens--681273 2D-image
3.9e-06-cyclosporin AVicia faba--653459 2D-image
0.00066-ethyl (2S)-1-(4,4-dimethyl-2-oxohexanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.001-ethyl (2S)-1-[(2-methoxycyclohexyl)(oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.002-ethyl (2S)-1-[cyclohexyl(oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.002-ethyl 1-(4,4-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.0043-ethyl 1-(4-methyl-2-oxopentanethioyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.002-ethyl 1-(4-methyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.001-ethyl 1-(5-ethoxy-4,4-dimethyl-2-oxopentanoyl)piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.008-ethyl 1-[(1-methoxycyclohexyl)(oxo)acetyl]pyrrolidine-2-carboxylateHomo sapiens--678713 2D-image
0.004-ethyl 1-[(3-methoxytetrahydro-2H-pyran-2-yl)(oxo)acetyl]piperidine-2-carboxylateHomo sapiens--678713 2D-image
0.044-linear CRYPEVEICHomo sapiens-using succinyl-Ala-Glu-(cis)-Pro-Phe-4-nitroanilide as substrate, in 50 mM HEPES, 0.1 M NaCl, 5 mM NaN3, pH 7.4, at 22°C715863-
1-Ser(PO3H2)-ProHomo sapiens--650106 2D-image
27-Ser-ProHomo sapiens--650106-
0.009-[(1S,2R,3S,6R,7aR)-2-(benzylcarbamoyl)-6-methoxy-3-naphthalen-2-ylhexahydro-1H-pyrrolizin-1-yl]methyl dihydrogen phosphateHomo sapiens--680060 2D-image
0.026-[(1S,2R,3S,6S,7aR)-2-(benzylcarbamoyl)-6-fluoro-3-naphthalen-2-ylhexahydro-1H-pyrrolizin-1-yl]methyl dihydrogen phosphateHomo sapiens--680060 2D-image
0.016-[(1S,2R,3S,7aR)-2-(benzylcarbamoyl)-3-(pentafluorophenyl)hexahydro-1H-pyrrolizin-1-yl]methyl dihydrogen phosphateHomo sapiens--680060 2D-image
0.015-[(1S,2R,3S,7aR)-2-(benzylcarbamoyl)-3-naphthalen-2-ylhexahydro-1H-pyrrolizin-1-yl]methyl dihydrogen phosphateHomo sapiens--680060 2D-image
0.044-[(1S,2R,3S,7aR)-2-(benzylcarbamoyl)-3-phenylhexahydro-1H-pyrrolizin-1-yl]methyl dihydrogen phosphateHomo sapiens--680060 2D-image
0.032-[(1S,2R,3S,7aR)-2-[(1,3-benzodioxol-5-ylmethyl)carbamoyl]-3-naphthalen-2-ylhexahydro-1H-pyrrolizin-1-yl]methyl dihydrogen phosphateHomo sapiens--680060 2D-image

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.0485-(1R,5S)-1-(phenylsulfonyl)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678742 2D-image
0.0092-(1R,5S)-1-(phenylthio)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678742 2D-image
0.0275-1-(1H-imidazol-2-ylthio)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678742 2D-image
0.0079-1-(pyridin-3-ylthio)bicyclo[3.3.1]nonan-3-oneHomo sapiens--678742 2D-image
0.002-2,7-dimethylbenzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetroneMus musculus-IC50: 0.002 mM650816 2D-image
0.0216-2-(4-((2R)-2-[(1R,3R,5R)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl)-2,6-dioxopiperidin-1-yl)acetamideHomo sapiens--681273 2D-image
0.00088-3,5-dichloro-N-(3-[(2-naphthylacetyl)amino]phenyl)benzamideHomo sapiens--681275 2D-image
0.00062-3,5-dichloro-N-[3-([[(2,4-dibromophenyl)amino]carbonyl]amino)phenyl]benzamideHomo sapiens--681275 2D-image
0.00069-3,5-dichloro-N-[3-([[(3,5-dichlorophenyl)amino]carbonyl]amino)phenyl]benzamideHomo sapiens--681275 2D-image
0.00087-3,5-dichloro-N-[3-[(3,3-diphenylpropanoyl)amino]phenyl]benzamideHomo sapiens--681275 2D-image
0.000943,5-dichloro-N-[3-[([[4-(trifluoromethyl)phenyl]amino]carbonyl)amino]phenyl]benzamideHomo sapiens--681275 2D-image
0.0036-4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperidinedioneHomo sapiens--681273 2D-image
0.0223-4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione-1-(4-ethyl butanoate)Homo sapiens--681273 2D-image
0.0044-4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione-1-(ethyl ethanoate)Homo sapiens--681273 2D-image
0.1-5-methoxy-1',3'dihydro-3H-spiro[1-benzofuran-2,2'-indene]-3-oneHomo sapiens--694290 2D-image
0.077-5-methoxy-2',3'-dihydro-3H-spiro[1-benzofuran-2,1'-indene]-3-oneHomo sapiens--694290 2D-image
0.065-5-methoxy-3H-spiro[1-benzofuran-2,1'-cyclopent[3]en]-3-oneHomo sapiens--694290 2D-image
0.215-Ac-Ala-GlyPSI(PO2Et-N)Pro-Phe-4-nitroanilideHomo sapiens-10°C681274 2D-image
1-Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-(t-butyl)Phe-Thr(PO3H2)-(methyl)Ala-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens-pH 7.8, 10°C681281 2D-image
8-Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-(t-butyl)Phe-Thr(PO3H2)-Yaa-Zaa-Gln-NH2Homo sapiens-pH 7.8, 10°C681281 2D-image
15-Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-beta-(2-thienyl)Ala-Thr(PO3H2)-(methyl)Ala-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens-pH 7.8, 10°C681281 2D-image
15-Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-beta-(3-benzothienyl)Ala-Thr(PO3H2)-piperidine-2-carboxylic acid-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens-pH 7.8, 10°C681281 2D-image
7-Ac-Lys(Nepsilon-biotinoyl)-Ala-Ala-beta-cyclohexylAla-Thr(PO3H2)-(methyl)Ala-beta-(2-naphthyl)Ala-Gln-NH2Homo sapiens-pH 7.8, 10°C681281 2D-image
0.001-acetyl-Ala-Ala-D-Ser(PO3H2)-Pro-Leu-NH-4-nitroanilideHomo sapiens-IC50: 0.001 mM650106 2D-image
0.085-acetyl-Ala-Ala-D-Ser-Pro-Leu-NH-4-nitroanilideHomo sapiens-IC50: 0.085 mM650106 2D-image
7-acetyl-Ala-Pro-Phe-4-(trimethylammonium)anilideHomo sapiens-IC50: 7 mM651287 2D-image
0.77-acetyl-Ala-Pro-Phe-4-nitroanilideHomo sapiens-IC50: 0.77 mM651287 2D-image
30-Ala-ProHomo sapiens-IC50: 30 mM651287 2D-image
0.0011-cyclo(Arg-Arg-Arg-D-pThr-Pip-Nal-Arg-Arg-Gln)Homo sapiens--705066-
0.3-cyclo(Arg-Arg-Arg-D-Thr-Pip-Nal-Arg-Arg-Gln)Homo sapiens-above705066-
0.063-cyclo(D-Ala-Gln-Glu-Mpa-Mal-Ile-Gln)Homo sapiens--705066-
4.3e-05-cyclo(D-Ala-Gly-D-pThr-Pip-Nal-Orn-Gln)Homo sapiens--705066-
0.0011-cyclo(D-Ala-Ile-D-pSer-Pro-Nal-Orn-Gln)Homo sapiens--705066-
0.00031-cyclo(D-Ala-Sar-D-pThr-Pip-Nal-Tyr-Gln)Homo sapiens--705066-
3.2e-05-cyclo(D-Ala-Sar-D-pThr-Pip-Nal-Tyr-Gln)-Lys-SHHomo sapiens--705066-
0.0025-cyclo(D-Arg-D-Arg-D-pThr-Pip-Nal-Arg-D-Arg-D-Arg-D-Arg-Gln)Homo sapiens--705066-
0.00022-cyclo(D-Arg-D-Arg-D-pThr-Pip-Nal-Arg-Gln)Homo sapiens--705066-
0.3-cyclo(D-Arg-D-Arg-D-Thr-Pip-Nal-Arg-D-Arg-D-Arg-D-Arg-Gln), cyclo(D-Arg-D-Arg-D-Thr-Pip-Nal-Arg-Gln)Homo sapiens-above705066-
2.65e-06-cyclosporin AHomo sapiens--691452 2D-image
1.4e-05-cyclosporin ASchistosoma mansoniQ2654810°C, pH 7.9680801 2D-image
1.6e-05-cyclosporin ACaenorhabditis elegans-IC50: 16 nM651964 2D-image
5e-05-cyclosporin ACaenorhabditis elegansP52014IC50: 50 nM652894 2D-image
0.0015-diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline 2,7-diacetateMus musculus-IC50: 0.0015 mM, inhibitor with the least non-specific toxicity650816 2D-image
0.0015-diethyl-1,3,8,10-tetrahydro-1,3,8,10-tetraoxoanthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-2,9-diacetateMus musculus-IC50: 0.0015 mM650816 2D-image
0.00011-FK506Zea mays-IC50: 110 nM653563 2D-image
0.00025-FK506Methanothermococcus thermolithotrophicusO52980IC50: 250 nM2525 2D-image
0.0086-methyl N-([(1R,2E)-2-[(2S)-2-hydroxy-4-methylpentylidene]-1-methylcyclopentyl]carbonyl)-L-tyrosinateHomo sapiens--678742 2D-image
0.00059-N,N''-(4,6-dibromo-1,3-phenylene)bis[3-(4-iodophenyl)urea]Homo sapiens--681275 2D-image
0.00093-N,N'-1,3-phenylenebis(3,5-dichlorobenzamide)Homo sapiens--681275 2D-image
0.004-Phe-Ser(PO3H2)-PSI[CS-N]-Pro-Phe-NH-4-nitroanilideHomo sapiens-IC50: 0.004 mM650106 2D-image
0.097-Phe-Ser-PSI[CS-N]-Pro-Phe-NH-4-nitroanilideHomo sapiens-IC50: 0.097 mM650106 2D-image
2-Ser(PO3H2)-ProHomo sapiens-IC50: 2.0 mM650106 2D-image
0.54-Suc-Ala-Ala-Pro-Phe-4-nitroanilideHomo sapiens-10°C681274 2D-image
0.015-Suc-Ala-GlyPSI(PO2Et-N)Pro-Phe-4-nitroanilideHomo sapiens-10°C681274 2D-image
14-succinyl-Ala-Ala-Pro-NH2Homo sapiens-IC50: 14 mM651287 2D-image
4.4-succinyl-Ala-Ala-Pro-Phe-4-carboxymethylanilideHomo sapiens-IC50: 4.4 mM651287 2D-image
0.54-succinyl-Ala-Ala-Pro-Phe-4-nitroanilideHomo sapiens-IC50: 0.54 mM651287 2D-image
5.8-succinyl-Ala-Pro-Phe-4-aminoanilideHomo sapiens-IC50: 5.8 mM651287 2D-image
0.7-succinyl-Ala-Pro-Phe-4-carboxmethylanilideHomo sapiens-IC50: 0.7 mM651287 2D-image
0.17-succinyl-Ala-Pro-Phe-4-nitroanilideHomo sapiens-IC50: 0.17 mM651287 2D-image
1.09-succinyl-Pro-Phe-4-nitroanilideHomo sapiens-IC50: 1.09 mM651287 2D-image

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
132.9-Schistosoma mansoni--2552
additional information-Sus scrofa--2510, 2511
additional information-Neurospora crassa--2514
additional information-Bos taurus, Homo sapiens--2516
additional information-Methanothermococcus thermolithotrophicusO52980-2525
additional information-Homo sapiens, Legionella pneumophila--2527
additional information-Plasmodium falciparum--2534
additional information-Zea mays--2535
additional information-Bos taurus--2536
additional information-Rattus norvegicus--2537
additional information-Geobacillus stearothermophilus--2550
additional information-Homo sapiens-WW module of enzyme can act as a negative regulator of enzymatic activity when multiple phosphorylation is present in substrates661761
additional information-Arabidopsis thalianaP34791the isomerization and disulfide-reduction activities are two independent functions of the enzyme that both are regulated by the redox state of the active centre. Dithiol-disulfide transitions have a regulatory role in protein function678048
additional information-Schistosoma mansoniQ26548ratio kcat/Km is 11000000 per M and s680801

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
6.6-Bordetella pertussis-assay at705408
78Geobacillus stearothermophilus--2550
7.8-Homo sapiens-assay at705066

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
69Geobacillus stearothermophilus-pH 6.0: about 50% of maximal activity, pH 9.0: about 45% of maximal activity, no activity below pH 5.0 and above pH 9.02550

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
20-Bordetella pertussis-assay at705408
60-Geobacillus stearothermophilus--2550

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
8.05-Bombyx moriB2LU30sequence calculation701596
8.1-Bordetella pertussisP40415calculated693627
8.3-Haemaphysalis longicornisB2ZWT4, B2ZWT5calculated694932
8.7-Chlamys farreriQ6USC1-694097
8.9-Ricinus communisQ8VX73calculated694779
9.1-Haemaphysalis longicornisB2ZWT4, B2ZWT5calculated694932

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
3T3-L1 cellHomo sapiens--715609Manually annotated by BRENDA team
adipocyteHomo sapiens--715609Manually annotated by BRENDA team
amastigoteTrypanosoma cruziB8XP93-714320Manually annotated by BRENDA team
B-50 cellRattus norvegicus-neuronal cell line660983Manually annotated by BRENDA team
B-cell lymphoma cellHomo sapiens--703021Manually annotated by BRENDA team
blood-lymphBombyx moriB2LU30-701596Manually annotated by BRENDA team
brainRattus norvegicus--2532, 704154, 705286, 705910Manually annotated by BRENDA team
brainHomo sapiens-foetal brain660614Manually annotated by BRENDA team
brainMus musculus-comparative analysis of enzyme activities and mRNA level of Pin1 and other prolyl cis/trans isomerases679822Manually annotated by BRENDA team
brainHomo sapiens--704154, 705286Manually annotated by BRENDA team
breast cancer cellHomo sapiens--705066Manually annotated by BRENDA team
BT-474 cellHomo sapiens--705066Manually annotated by BRENDA team
carcinoma cellHomo sapiens--679270Manually annotated by BRENDA team
carcinoma cellHomo sapiens-the enzyme is upregulated in cancer cells703021Manually annotated by BRENDA team
carcinoma cellHomo sapiens-strong correlation between the expression levels of an oncogenic peptidyl-prolyl cis/trans isomerase Pin1 and levels of Akt phosphorylation at S473 and the Thr92-Pro and Thr450-Pro motifs in multiple cancer types, overview706012Manually annotated by BRENDA team
cell cultureHomo sapiens-primary cortical culture693136Manually annotated by BRENDA team
cell cultureSalmonella enterica subsp. enterica serovar Typhimurium-carbon-starved cells701755Manually annotated by BRENDA team
colonHomo sapiens--679270Manually annotated by BRENDA team
COS-7 cellHomo sapiens-overexpression of isoform Pin1 decreases levels of the inhibitor of apoptosis protein Survivin678442Manually annotated by BRENDA team
embryoBombyx moriB2LU30-701596Manually annotated by BRENDA team
embryoRattus norvegicus--705286Manually annotated by BRENDA team
embryoXenopus laevis--705910, 714800Manually annotated by BRENDA team
eosinophilHomo sapiens-primary705854Manually annotated by BRENDA team
epidermisHaemaphysalis longicornisB2ZWT4, B2ZWT5; 694932Manually annotated by BRENDA team
epimastigoteTrypanosoma cruziQ2I5R9neither cell growth kinetics nor cell morphology are affected by the overexpression of Pin1681821Manually annotated by BRENDA team
epimastigoteTrypanosoma cruziB8XP93-714320Manually annotated by BRENDA team
fatMus musculus--715609Manually annotated by BRENDA team
fat bodyBombyx moriB2LU30-701596Manually annotated by BRENDA team
fetusHomo sapiens-foetal brain660614Manually annotated by BRENDA team
fibroblastMus musculus-embryonic fibroblast,comparative analysis of enzyme activities and mRNA level of Pin1 and other prolyl cis/trans isomerases679822Manually annotated by BRENDA team
fibroblastHomo sapiens--703024, 705427Manually annotated by BRENDA team
flowerArabidopsis thalianaP34790, P34791ROC1 and ROC4651848Manually annotated by BRENDA team
flower budBrassica napus--653605Manually annotated by BRENDA team
gonadChlamys farreriQ6USC1highest expression level of mRNA, expression is inducible694097Manually annotated by BRENDA team
H9 cellHomo sapiens--705427Manually annotated by BRENDA team
HEK-293 cellHomo sapiens--693136, 705715Manually annotated by BRENDA team
HEK-293-EBNA cellHomo sapiens--705715Manually annotated by BRENDA team
HEK-293T cellHomo sapiens--680662, 691625, 703024Manually annotated by BRENDA team
HeLa cellHomo sapiens--681281, 681919, 703024, 705066, 705715Manually annotated by BRENDA team
hematopoietic stem cellHomo sapiens--660910Manually annotated by BRENDA team
hemocyteChlamys farreriQ6USC1constitutive expression694097Manually annotated by BRENDA team
hemolymphBombyx moriB2LU30-701596Manually annotated by BRENDA team
hepatocyteMus musculus--704931Manually annotated by BRENDA team
hippocampusRattus norvegicusO42123-705910Manually annotated by BRENDA team
Huh-7.5 cellHomo sapiens--705430Manually annotated by BRENDA team
JURKAT cellHomo sapiens--2539, 705427Manually annotated by BRENDA team
kidneySus scrofa--2507, 2509, 2510, 2515, 2517Manually annotated by BRENDA team
kidneySus scrofa-cortex2508, 2511, 2512Manually annotated by BRENDA team
kidneyRattus norvegicus--2532Manually annotated by BRENDA team
KM-H2 cellHomo sapiens-a Hodkin's lymphoma cell line703021Manually annotated by BRENDA team
Kupffer cellMus musculus--704931Manually annotated by BRENDA team
L-929 cellMus musculus-a fibroblast cell line705715Manually annotated by BRENDA team
leafArabidopsis thalianaP34790, P34791ROC1 and ROC4651848Manually annotated by BRENDA team
leafVicia faba-mRNA level is high,expression of the transcript in the leaf tissue is regulated by light and induced by heat shock653459Manually annotated by BRENDA team
leafOryza sativaQ40672, Q40673expressed as a 1000 nt transcript in leaf and root; the enzyme is expressed as 800 nt and 900 nt transcripts. Whereas the 900 nt transcript is present in both root and leaf mRNA, the 800 nt transcript is only detectable in root mRNA653484Manually annotated by BRENDA team
leafBrassica napus-young653605Manually annotated by BRENDA team
leafSorghum bicolor--682273Manually annotated by BRENDA team
liverRattus norvegicus--2520, 2532, 2537Manually annotated by BRENDA team
liverBos taurus--2520, 2536Manually annotated by BRENDA team
liverHomo sapiens--662835Manually annotated by BRENDA team
liverMus musculus-comparative analysis of enzyme activities and mRNA level of Pin1 and other prolyl cis/trans isomerases679822Manually annotated by BRENDA team
liverMus musculus--704931, 715609Manually annotated by BRENDA team
lungMus musculus-comparative analysis of enzyme activities and mRNA level of Pin1 and other prolyl cis/trans isomerases679822Manually annotated by BRENDA team
lymphocyteHomo sapiens-CD4+ lymphocyte. Enzyme isoform Pin1 is necessary for activation-dependent mRNA stabilization, accumulation, and protein secretion of cytokine GM-CSF. Pin1 mediates the association of the AU-rich element-binding protein, AUF1, with GM-CSF mRNA681198Manually annotated by BRENDA team
lymphocyteHomo sapiens-primary703021Manually annotated by BRENDA team
malpighian tubuleBombyx moriB2LU30-701596Manually annotated by BRENDA team
MCF-7 cellHomo sapiens-breast cancer cell662861Manually annotated by BRENDA team
MCF-7 cellHomo sapiens--691626Manually annotated by BRENDA team
MDA-MB-231 cellHomo sapiens--691626Manually annotated by BRENDA team
muscleMus musculus--715609Manually annotated by BRENDA team
neuroblastoma cellHomo sapiens--678442Manually annotated by BRENDA team
neuronRattus norvegicusB0BNL2primary cortical neuron, enzyme isoform Pin1 partly colocalizes with phosphoprotein Tau,which is involved in Alzheimer’s disease680665Manually annotated by BRENDA team
neuronRattus norvegicus--704154, 705910Manually annotated by BRENDA team
neuronHomo sapiens--704154Manually annotated by BRENDA team
neuronHomo sapiens-cortical705286Manually annotated by BRENDA team
neuronRattus norvegicus-primary cortical, Pin1 is present in both axons and cell bodies705286Manually annotated by BRENDA team
neuronXenopus laevisO42123-705910Manually annotated by BRENDA team
NIH-3T3 cellHomo sapiens--680662Manually annotated by BRENDA team
NIH-3T3-A14 cellHomo sapiens--691625Manually annotated by BRENDA team
ovarySolanum lycopersicum--653605Manually annotated by BRENDA team
ovaryMus musculusQ9QUR7of mice treated with equine or human chorionic gonadotropin, eCG or hCG, resp.681633Manually annotated by BRENDA team
ovaryHaemaphysalis longicornisB2ZWT4, B2ZWT5-694932Manually annotated by BRENDA team
ovaryBombyx moriB2LU30-701596Manually annotated by BRENDA team
P-19 cellHomo sapiens--694818Manually annotated by BRENDA team
PC-12 cellHomo sapiens--694818Manually annotated by BRENDA team
peripheral blood mononuclear cellHomo sapiens-enzyme isoform Pin1 is necessary for activation-dependent mRNA stabilization, accumulation, and protein secretion of cytokine GM-CSF. Pin1 mediates the association of the AU-rich element-binding protein, AUF1, with GM-CSF mRNA681198Manually annotated by BRENDA team
phloemRicinus communisQ8VX73phloem translocation stream694779Manually annotated by BRENDA team
placentaHomo sapiens-co-localization of cyclophilin B and channel protein TRPV6 in the syncytiotropoblast layer, with small amounts of both in microvilli apical membrane693077Manually annotated by BRENDA team
preadipocyteHomo sapiens--715609Manually annotated by BRENDA team
rootArabidopsis thalianaP34790, P34791ROC1, no ROC4 mRNA detected651848Manually annotated by BRENDA team
rootOryza sativaQ40672, Q40673expressed as a 1000 nt transcript in leaf and root; the enzyme is expressed as 800 nt and 900 nt transcripts. Whereas the 900 nt transcript is present in both root and leaf mRNA, the 800 nt transcript is only detectable in root mRNA653484Manually annotated by BRENDA team
rootBrassica napus-from germinated seeds653605Manually annotated by BRENDA team
salivary glandHaemaphysalis longicornisB2ZWT4, B2ZWT5; 694932Manually annotated by BRENDA team
seedlingSolanum lycopersicum--653605Manually annotated by BRENDA team
seedlingRicinus communisQ8VX73-694779Manually annotated by BRENDA team
sepalSolanum lycopersicum--653605Manually annotated by BRENDA team
SH-SY5Y cellHomo sapiens-neuroblastoma cell, overexpression of isoform Pin1 decreases levels of the inhibitor of apoptosis protein, Survivin. Pin1 and Survivin partially co-localize in interphase and mitotic cells and form a complex. Pin1 silencing leads to an increase in Survivin levels678442Manually annotated by BRENDA team
shootZea mays-etiolated2535Manually annotated by BRENDA team
silk glandBombyx moriB2LU30-701596Manually annotated by BRENDA team
spleenHomo sapiens--2516Manually annotated by BRENDA team
spleenRattus norvegicus--2532Manually annotated by BRENDA team
stamenBrassica napus-immature653605Manually annotated by BRENDA team
synganglionHaemaphysalis longicornisB2ZWT4, B2ZWT5; 694932Manually annotated by BRENDA team
T-47D cellHomo sapiens--691626Manually annotated by BRENDA team
T-lymphocyteHomo sapiens--2519, 2531, 2546, 705427Manually annotated by BRENDA team
testisMus musculus-comparative analysis of enzyme activities and mRNA level of Pin1 and other prolyl cis/trans isomerases679822Manually annotated by BRENDA team
testisBombyx moriB2LU30-701596Manually annotated by BRENDA team
thymusBos taurus--2516, 2549Manually annotated by BRENDA team
trypomastigoteTrypanosoma cruziB8XP93-714320Manually annotated by BRENDA team
tuba MalpighiiBombyx moriB2LU30-701596Manually annotated by BRENDA team
midgutBombyx moriB2LU30-701596Manually annotated by BRENDA team
additional informationArabidopsis thalianaP34790, P34791no activity detected in root. ROC4 is expressed only in photosynthetic organs; ROC1 is expressed in all tested plant organs651848Manually annotated by BRENDA team
additional informationVicia faba-mRNA level for pCyP B is not detectable in root653459Manually annotated by BRENDA team
additional informationChlamys farreriQ6USC1mRNA transcripts are detected in all tissues examined694097Manually annotated by BRENDA team
additional informationRicinus communisQ8VX73abundant protein in the companion cell sieve element complex694779Manually annotated by BRENDA team
additional informationHaemaphysalis longicornisB2ZWT4, B2ZWT5mRNA expression level is homogeneous in different tissues; mRNA expression level is homogeneous in different tissues694932Manually annotated by BRENDA team
additional informationBombyx moriB2LU30broad tissue PPIase expression pattern701596Manually annotated by BRENDA team
additional informationCampylobacter jejuni-expression of cj0596 is slightly higher at 37°C than at 42°C702908Manually annotated by BRENDA team

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
cell surfaceLegionella pneumophila--9986680130Manually annotated by BRENDA team
chloroplastPisum sativum-cyclosporin A-sensitive activity in the chloroplast is mostly localized to the thylakoids, activity associated with the chloroplast stroma and the thylakoids is not inhibited by rapamycin9507651842Manually annotated by BRENDA team
chloroplastArabidopsis thalianaP34790, P34791; in stroma of chloroplasts, not in thylakoid membrane and thylakoid lumen the ROC4 protein is imported into chloroplasts where it is processed to the predicted mature size9507651848Manually annotated by BRENDA team
chloroplastVicia faba--9507653459Manually annotated by BRENDA team
chloroplastArabidopsis thaliana-lumen of thylakoid, enzyme isoforms AtCYP20-2 and AtFKBP13. In thiol-reducing conditions, enzyme activity of AtFKBP13 is suppressed severalfold9507679826Manually annotated by BRENDA team
chloroplastArabidopsis thalianaQ9SCY2stroma and lumen9507706176Manually annotated by BRENDA team
chloroplast stromaArabidopsis thalianaQ9SCY2CYP20-39570706176Manually annotated by BRENDA team
cytoplasmEscherichia coli-anionic enzyme form. Antibodies against the periplasmic enzyme form do not recognize the cytoplasmic enzyme, indicating significant differences in epitopes between the two forms57372533Manually annotated by BRENDA team
cytoplasmEscherichia coli--57372554Manually annotated by BRENDA team
cytoplasmCaenorhabditis elegansP52014-5737652894Manually annotated by BRENDA team
cytoplasmHomo sapiens-Pin1 and the inhibitor of apoptosis protein, Survivin partially co-localize in interphase and mitotic cells5737678442Manually annotated by BRENDA team
cytoplasmBombyx moriB2LU30-5737701596Manually annotated by BRENDA team
cytoplasmHomo sapiens, Mus musculus--5737705715Manually annotated by BRENDA team
cytosolNeurospora crassa--58292514Manually annotated by BRENDA team
cytosolHomo sapiens--58292516, 2518, 653822Manually annotated by BRENDA team
cytosolBos taurus--58292516, 2549Manually annotated by BRENDA team
cytosolSaccharomyces cerevisiae--58292526Manually annotated by BRENDA team
cytosolHomo sapiens-isoform CyP158292531Manually annotated by BRENDA team
cytosolRattus norvegicus-2 isoforms58292532Manually annotated by BRENDA team
cytosolZea mays--58292535, 653563Manually annotated by BRENDA team
cytosolPisum sativum--5829651842Manually annotated by BRENDA team
endoplasmic reticulumBos taurus-lumen57832520, 2536Manually annotated by BRENDA team
endoplasmic reticulumRattus norvegicus-lumen57832520Manually annotated by BRENDA team
endoplasmic reticulumGallus gallus-rough57832522Manually annotated by BRENDA team
extracellularLegionella pneumophila-enzyme is present in 17°C supernatants of type II and type IV secretion mutants, although it lacks a signal sequence-690528Manually annotated by BRENDA team
membraneHomo sapiens-and/or organelles, isoforms CyP2 and CyP3160202531Manually annotated by BRENDA team
membraneNeisseria gonorrhoeae-surface-exposed16020662909Manually annotated by BRENDA team
membraneBacillus subtilis--16020716254Manually annotated by BRENDA team
microsomeRattus norvegicus---2520, 2532Manually annotated by BRENDA team
microsomeBos taurus---2520, 2536Manually annotated by BRENDA team
microsomeZea mays---2535Manually annotated by BRENDA team
microtubuleMus musculus--5874662319Manually annotated by BRENDA team
mitochondrionNeurospora crassa--57392514Manually annotated by BRENDA team
mitochondrionSaccharomyces cerevisiae-mitochondrial form not detected57392526Manually annotated by BRENDA team
mitochondrionRattus norvegicus-matrix57392537, 660983Manually annotated by BRENDA team
nucleusHomo sapiens-bound to double-stranded DNA. The subcellular localization is regulated by posttranslational modification of its N-terminal domain5634652918Manually annotated by BRENDA team
nucleusZea mays--5634653563Manually annotated by BRENDA team
nucleusHomo sapiens--5634660910Manually annotated by BRENDA team
nucleusHaemonchus contortusQ4G338mostly5634663015Manually annotated by BRENDA team
nucleusHomo sapiens-Pin1 and the inhibitor of apoptosis protein, Survivin partially co-localize in interphase and mitotic cells5634678442Manually annotated by BRENDA team
nucleusHomo sapiens, Mus musculus-endogenous Par14 is present in nuclear Pre-40 S and Pre-60 S ribosomal fractions5634705715Manually annotated by BRENDA team
nucleusTrypanosoma cruziB8XP93Par45 is mainly concentrated in the nucleus5634714320Manually annotated by BRENDA team
outer membraneRickettsia prowazekiiQ9ZCX6-19867661913Manually annotated by BRENDA team
periplasmEscherichia coli-cationic enzyme form-2533Manually annotated by BRENDA team
periplasmEscherichia coli---2538, 2554, 652932, 662045, 692303, 715653Manually annotated by BRENDA team
periplasmErwinia chrysanthemi---2551Manually annotated by BRENDA team
periplasmBordetella pertussis---693627, 705408Manually annotated by BRENDA team
periplasmSalmonella enterica subsp. enterica serovar Typhimurium---701755Manually annotated by BRENDA team
periplasmCampylobacter jejuni---702908Manually annotated by BRENDA team
plasmodesmaRicinus communisQ8VX73purified recombinant enzyme interacts with plasmodesmata to both induce an increase in size exclusion limit and mediate its own cell-to-cell trafficking9506694779Manually annotated by BRENDA team
solubleMycobacterium tuberculosisP65762--661643Manually annotated by BRENDA team
spindleHomo sapiens--5819715712Manually annotated by BRENDA team
spliceosome complexHomo sapiens-cyclophilin H is a component of the human U4/U5 small nuclear ribonucleoprotein particle, interacting with homologous sequences in the proteins U4/U6-60K and hPr18 during Pre-mRNA splicing-652921Manually annotated by BRENDA team
thylakoidArabidopsis thalianaQ9SCY2lumen, CYP20-2 and FKBP139579706176Manually annotated by BRENDA team
virionAcanthamoeba polyphaga MimivirusQ5UP71surface of the mature virion19012693639Manually annotated by BRENDA team
mitochondrionPisum sativum-cyclosporin A-sensitive activity is largely localized to the mitochondrial matrix. Rapamycin-sensitive activity is associated with the mitochondrial membranes5739651842Manually annotated by BRENDA team
additional informationPisum sativum-presence of distinct classes of peptidyl cis,trans-isomerases in the mitochondria and the chloroplast of plants-651842Manually annotated by BRENDA team
additional informationHomo sapiens-in mitotic cells, Pin1 is located in the midbody ring-703024Manually annotated by BRENDA team
additional informationHomo sapiens, Rattus norvegicus-Pin1 associates with neurofilaments-704154Manually annotated by BRENDA team
additional informationHomo sapiens, Mus musculus-co-localizing with the nucleolar-specific protein B23 in quiescent cells, Par14 localizes to the nucleolus of those cells during interphase, and Par14 co-localized almost completely with B23 in the spindle apparatus during mitosis-705715Manually annotated by BRENDA team

PDBSCOPCATHORGANISM
2ose, downloadSCOP (2ose)CATH (2ose)Acanthamoeba polyphaga mimivirus
3uqi, downloadSCOP (3uqi)CATH (3uqi)Aedes aegypti
1u79, downloadSCOP (1u79)CATH (1u79)Arabidopsis thaliana
1y0o, downloadSCOP (1y0o)CATH (1y0o)Arabidopsis thaliana
3rfy, downloadSCOP (3rfy)CATH (3rfy)Arabidopsis thaliana
3t1u, downloadSCOP (3t1u)CATH (3t1u)Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
1zk6, downloadSCOP (1zk6)CATH (1zk6)Bacillus subtilis (strain 168)
1fkk, downloadSCOP (1fkk)CATH (1fkk)Bos taurus
1fkl, downloadSCOP (1fkl)CATH (1fkl)Bos taurus
1ihg, downloadSCOP (1ihg)CATH (1ihg)Bos taurus
1iip, downloadSCOP (1iip)CATH (1iip)Bos taurus
1a33, downloadSCOP (1a33)CATH (1a33)Brugia malayi
1c5f, downloadSCOP (1c5f)CATH (1c5f)Brugia malayi
2l2s, downloadSCOP (2l2s)CATH (2l2s)Burkholderia pseudomallei (strain 1710b)
3s6m, downloadSCOP (3s6m)CATH (3s6m)Burkholderia pseudomallei (strain 1710b)
4dz2, downloadSCOP (4dz2)CATH (4dz2)Burkholderia pseudomallei (strain 1710b)
4dz3, downloadSCOP (4dz3)CATH (4dz3)Burkholderia pseudomallei (strain 1710b)
2ke0, downloadSCOP (2ke0)CATH (2ke0)Burkholderia pseudomallei (strain K96243)
2ko7, downloadSCOP (2ko7)CATH (2ko7)Burkholderia pseudomallei (strain K96243)
2y78, downloadSCOP (2y78)CATH (2y78)Burkholderia pseudomallei (strain K96243)
1dyw, downloadSCOP (1dyw)CATH (1dyw)Caenorhabditis elegans
1h0p, downloadSCOP (1h0p)CATH (1h0p)Caenorhabditis elegans
2igv, downloadSCOP (2igv)CATH (2igv)Caenorhabditis elegans
2igw, downloadSCOP (2igw)CATH (2igw)Caenorhabditis elegans
1yw5, downloadSCOP (1yw5)CATH (1yw5)Candida albicans (strain SC5314 / ATCC MYA-2876)
2rqs, downloadSCOP (2rqs)CATH (2rqs)Cenarchaeum symbiosum (strain A)
1cwa, downloadSCOP (1cwa)CATH (1cwa)Chlorocebus aethiops
1cwb, downloadSCOP (1cwb)CATH (1cwb)Chlorocebus aethiops
1cwc, downloadSCOP (1cwc)CATH (1cwc)Chlorocebus aethiops
1cwj, downloadSCOP (1cwj)CATH (1cwj)Chlorocebus aethiops
1cwk, downloadSCOP (1cwk)CATH (1cwk)Chlorocebus aethiops
1cwl, downloadSCOP (1cwl)CATH (1cwl)Chlorocebus aethiops
1mik, downloadSCOP (1mik)CATH (1mik)Chlorocebus aethiops
2cyh, downloadSCOP (2cyh)CATH (2cyh)Chlorocebus aethiops
3cyh, downloadSCOP (3cyh)CATH (3cyh)Chlorocebus aethiops
3cys, downloadSCOP (3cys)CATH (3cys)Chlorocebus aethiops
4cyh, downloadSCOP (4cyh)CATH (4cyh)Chlorocebus aethiops
2jv4, downloadSCOP (2jv4)CATH (2jv4)Emericella nidulans
3k2c, downloadSCOP (3k2c)CATH (3k2c)Encephalitozoon cuniculi (strain GB-M1)
4fru, downloadSCOP (4fru)CATH (4fru)Equus caballus
4frv, downloadSCOP (4frv)CATH (4frv)Equus caballus
1j2a, downloadSCOP (1j2a)CATH (1j2a)Escherichia coli (strain K12)
1jns, downloadSCOP (1jns)CATH (1jns)Escherichia coli (strain K12)
1jnt, downloadSCOP (1jnt)CATH (1jnt)Escherichia coli (strain K12)
1l1p, downloadSCOP (1l1p)CATH (1l1p)Escherichia coli (strain K12)
1lop, downloadSCOP (1lop)CATH (1lop)Escherichia coli (strain K12)
1m5y, downloadSCOP (1m5y)CATH (1m5y)Escherichia coli (strain K12)
1oms, downloadSCOP (1oms)CATH (1oms)Escherichia coli (strain K12)
1p9y, downloadSCOP (1p9y)CATH (1p9y)Escherichia coli (strain K12)
1q6h, downloadSCOP (1q6h)CATH (1q6h)Escherichia coli (strain K12)
1q6i, downloadSCOP (1q6i)CATH (1q6i)Escherichia coli (strain K12)
1q6u, downloadSCOP (1q6u)CATH (1q6u)Escherichia coli (strain K12)
1v9t, downloadSCOP (1v9t)CATH (1v9t)Escherichia coli (strain K12)
1vai, downloadSCOP (1vai)CATH (1vai)Escherichia coli (strain K12)
2kfw, downloadSCOP (2kfw)CATH (2kfw)Escherichia coli (strain K12)
2kgj, downloadSCOP (2kgj)CATH (2kgj)Escherichia coli (strain K12)
2nul, downloadSCOP (2nul)CATH (2nul)Escherichia coli (strain K12)
2pv1, downloadSCOP (2pv1)CATH (2pv1)Escherichia coli (strain K12)
2pv2, downloadSCOP (2pv2)CATH (2pv2)Escherichia coli (strain K12)
2pv3, downloadSCOP (2pv3)CATH (2pv3)Escherichia coli (strain K12)
2rs4, downloadSCOP (2rs4)CATH (2rs4)Escherichia coli (strain K12)
4dt4, downloadSCOP (4dt4)CATH (4dt4)Escherichia coli (strain K12)
1j2a, downloadSCOP (1j2a)CATH (1j2a)Escherichia coli O157:H7
1v9t, downloadSCOP (1v9t)CATH (1v9t)Escherichia coli O157:H7
1vai, downloadSCOP (1vai)CATH (1vai)Escherichia coli O157:H7
2k8i, downloadSCOP (2k8i)CATH (2k8i)Escherichia coli O1:K1 / APEC
1j2a, downloadSCOP (1j2a)CATH (1j2a)Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
1v9t, downloadSCOP (1v9t)CATH (1v9t)Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
1vai, downloadSCOP (1vai)CATH (1vai)Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
2kr7, downloadSCOP (2kr7)CATH (2kr7)Helicobacter pylori (strain ATCC 700392 / 26695)
1a7x, downloadSCOP (1a7x)CATH (1a7x)Homo sapiens
1ak4, downloadSCOP (1ak4)CATH (1ak4)Homo sapiens
1awq, downloadSCOP (1awq)CATH (1awq)Homo sapiens
1awr, downloadSCOP (1awr)CATH (1awr)Homo sapiens
1aws, downloadSCOP (1aws)CATH (1aws)Homo sapiens
1awt, downloadSCOP (1awt)CATH (1awt)Homo sapiens
1awu, downloadSCOP (1awu)CATH (1awu)Homo sapiens
1awv, downloadSCOP (1awv)CATH (1awv)Homo sapiens
1b6c, downloadSCOP (1b6c)CATH (1b6c)Homo sapiens
1bck, downloadSCOP (1bck)CATH (1bck)Homo sapiens
1bkf, downloadSCOP (1bkf)CATH (1bkf)Homo sapiens
1bl4, downloadSCOP (1bl4)CATH (1bl4)Homo sapiens
1cwa, downloadSCOP (1cwa)CATH (1cwa)Homo sapiens
1cwb, downloadSCOP (1cwb)CATH (1cwb)Homo sapiens
1cwc, downloadSCOP (1cwc)CATH (1cwc)Homo sapiens
1cwf, downloadSCOP (1cwf)CATH (1cwf)Homo sapiens
1cwh, downloadSCOP (1cwh)CATH (1cwh)Homo sapiens
1cwi, downloadSCOP (1cwi)CATH (1cwi)Homo sapiens
1cwj, downloadSCOP (1cwj)CATH (1cwj)Homo sapiens
1cwk, downloadSCOP (1cwk)CATH (1cwk)Homo sapiens
1cwl, downloadSCOP (1cwl)CATH (1cwl)Homo sapiens
1cwm, downloadSCOP (1cwm)CATH (1cwm)Homo sapiens
1cwo, downloadSCOP (1cwo)CATH (1cwo)Homo sapiens
1cyn, downloadSCOP (1cyn)CATH (1cyn)Homo sapiens
1d6o, downloadSCOP (1d6o)CATH (1d6o)Homo sapiens
1d7h, downloadSCOP (1d7h)CATH (1d7h)Homo sapiens
1d7i, downloadSCOP (1d7i)CATH (1d7i)Homo sapiens
1d7j, downloadSCOP (1d7j)CATH (1d7j)Homo sapiens
1eym, downloadSCOP (1eym)CATH (1eym)Homo sapiens
1f8a, downloadSCOP (1f8a)CATH (1f8a)Homo sapiens
1fap, downloadSCOP (1fap)CATH (1fap)Homo sapiens
1fkj, downloadSCOP (1fkj)CATH (1fkj)Homo sapiens
1i6c, downloadSCOP (1i6c)CATH (1i6c)Homo sapiens
1i8g, downloadSCOP (1i8g)CATH (1i8g)Homo sapiens
1i8h, downloadSCOP (1i8h)CATH (1i8h)Homo sapiens
1j4h, downloadSCOP (1j4h)CATH (1j4h)Homo sapiens
1j4i, downloadSCOP (1j4i)CATH (1j4i)Homo sapiens
1j4r, downloadSCOP (1j4r)CATH (1j4r)Homo sapiens
1kt0, downloadSCOP (1kt0)CATH (1kt0)Homo sapiens
1m63, downloadSCOP (1m63)CATH (1m63)Homo sapiens
1m9c, downloadSCOP (1m9c)CATH (1m9c)Homo sapiens
1m9d, downloadSCOP (1m9d)CATH (1m9d)Homo sapiens
1m9e, downloadSCOP (1m9e)CATH (1m9e)Homo sapiens
1m9f, downloadSCOP (1m9f)CATH (1m9f)Homo sapiens
1m9x, downloadSCOP (1m9x)CATH (1m9x)Homo sapiens
1m9y, downloadSCOP (1m9y)CATH (1m9y)Homo sapiens
1mf8, downloadSCOP (1mf8)CATH (1mf8)Homo sapiens
1mik, downloadSCOP (1mik)CATH (1mik)Homo sapiens
1n1a, downloadSCOP (1n1a)CATH (1n1a)Homo sapiens
1nmk, downloadSCOP (1nmk)CATH (1nmk)Homo sapiens
1nmv, downloadSCOP (1nmv)CATH (1nmv)Homo sapiens
1nmw, downloadSCOP (1nmw)CATH (1nmw)Homo sapiens
1nsg, downloadSCOP (1nsg)CATH (1nsg)Homo sapiens
1oca, downloadSCOP (1oca)CATH (1oca)Homo sapiens
1p5q, downloadSCOP (1p5q)CATH (1p5q)Homo sapiens
1pin, downloadSCOP (1pin)CATH (1pin)Homo sapiens
1q1c, downloadSCOP (1q1c)CATH (1q1c)Homo sapiens
1qz2, downloadSCOP (1qz2)CATH (1qz2)Homo sapiens
1tco, downloadSCOP (1tco)CATH (1tco)Homo sapiens
1w8l, downloadSCOP (1w8l)CATH (1w8l)Homo sapiens
1w8m, downloadSCOP (1w8m)CATH (1w8m)Homo sapiens
1w8v, downloadSCOP (1w8v)CATH (1w8v)Homo sapiens
1xwn, downloadSCOP (1xwn)CATH (1xwn)Homo sapiens
1xyh, downloadSCOP (1xyh)CATH (1xyh)Homo sapiens
1ynd, downloadSCOP (1ynd)CATH (1ynd)Homo sapiens
1zcn, downloadSCOP (1zcn)CATH (1zcn)Homo sapiens
1zkc, downloadSCOP (1zkc)CATH (1zkc)Homo sapiens
1zkf, downloadSCOP (1zkf)CATH (1zkf)Homo sapiens
1zmf, downloadSCOP (1zmf)CATH (1zmf)Homo sapiens
2a2n, downloadSCOP (2a2n)CATH (2a2n)Homo sapiens
2alf, downloadSCOP (2alf)CATH (2alf)Homo sapiens
2bit, downloadSCOP (2bit)CATH (2bit)Homo sapiens
2biu, downloadSCOP (2biu)CATH (2biu)Homo sapiens
2cqb, downloadSCOP (2cqb)CATH (2cqb)Homo sapiens
2cyh, downloadSCOP (2cyh)CATH (2cyh)Homo sapiens
2dg3, downloadSCOP (2dg3)CATH (2dg3)Homo sapiens
2dg4, downloadSCOP (2dg4)CATH (2dg4)Homo sapiens
2dg9, downloadSCOP (2dg9)CATH (2dg9)Homo sapiens
2esl, downloadSCOP (2esl)CATH (2esl)Homo sapiens
2f21, downloadSCOP (2f21)CATH (2f21)Homo sapiens
2fap, downloadSCOP (2fap)CATH (2fap)Homo sapiens
2gw2, downloadSCOP (2gw2)CATH (2gw2)Homo sapiens
2he9, downloadSCOP (2he9)CATH (2he9)Homo sapiens
2itk, downloadSCOP (2itk)CATH (2itk)Homo sapiens
2k7n, downloadSCOP (2k7n)CATH (2k7n)Homo sapiens
2kbu, downloadSCOP (2kbu)CATH (2kbu)Homo sapiens
2kcf, downloadSCOP (2kcf)CATH (2kcf)Homo sapiens
2kfv, downloadSCOP (2kfv)CATH (2kfv)Homo sapiens
2kyx, downloadSCOP (2kyx)CATH (2kyx)Homo sapiens
2lb3, downloadSCOP (2lb3)CATH (2lb3)Homo sapiens
2oju, downloadSCOP (2oju)CATH (2oju)Homo sapiens
2ok3, downloadSCOP (2ok3)CATH (2ok3)Homo sapiens
2pbc, downloadSCOP (2pbc)CATH (2pbc)Homo sapiens
2ppn, downloadSCOP (2ppn)CATH (2ppn)Homo sapiens
2ppo, downloadSCOP (2ppo)CATH (2ppo)Homo sapiens
2ppp, downloadSCOP (2ppp)CATH (2ppp)Homo sapiens
2q5a, downloadSCOP (2q5a)CATH (2q5a)Homo sapiens
2r99, downloadSCOP (2r99)CATH (2r99)Homo sapiens
2rma, downloadSCOP (2rma)CATH (2rma)Homo sapiens
2rmb, downloadSCOP (2rmb)CATH (2rmb)Homo sapiens
2rse, downloadSCOP (2rse)CATH (2rse)Homo sapiens
2wfi, downloadSCOP (2wfi)CATH (2wfi)Homo sapiens
2wfj, downloadSCOP (2wfj)CATH (2wfj)Homo sapiens
2x25, downloadSCOP (2x25)CATH (2x25)Homo sapiens
2x2a, downloadSCOP (2x2a)CATH (2x2a)Homo sapiens
2x2c, downloadSCOP (2x2c)CATH (2x2c)Homo sapiens
2x2d, downloadSCOP (2x2d)CATH (2x2d)Homo sapiens
2x7k, downloadSCOP (2x7k)CATH (2x7k)Homo sapiens
2xgy, downloadSCOP (2xgy)CATH (2xgy)Homo sapiens
2xp3, downloadSCOP (2xp3)CATH (2xp3)Homo sapiens
2xp4, downloadSCOP (2xp4)CATH (2xp4)Homo sapiens
2xp5, downloadSCOP (2xp5)CATH (2xp5)Homo sapiens
2xp6, downloadSCOP (2xp6)CATH (2xp6)Homo sapiens
2xp7, downloadSCOP (2xp7)CATH (2xp7)Homo sapiens
2xp8, downloadSCOP (2xp8)CATH (2xp8)Homo sapiens
2xp9, downloadSCOP (2xp9)CATH (2xp9)Homo sapiens
2xpa, downloadSCOP (2xpa)CATH (2xpa)Homo sapiens
2xpb, downloadSCOP (2xpb)CATH (2xpb)Homo sapiens
2z6w, downloadSCOP (2z6w)CATH (2z6w)Homo sapiens
2zqs, downloadSCOP (2zqs)CATH (2zqs)Homo sapiens
2zqt, downloadSCOP (2zqt)CATH (2zqt)Homo sapiens
2zqu, downloadSCOP (2zqu)CATH (2zqu)Homo sapiens
2zqv, downloadSCOP (2zqv)CATH (2zqv)Homo sapiens
2zr4, downloadSCOP (2zr4)CATH (2zr4)Homo sapiens
2zr5, downloadSCOP (2zr5)CATH (2zr5)Homo sapiens
2zr6, downloadSCOP (2zr6)CATH (2zr6)Homo sapiens
3b7x, downloadSCOP (3b7x)CATH (3b7x)Homo sapiens
3cyh, downloadSCOP (3cyh)CATH (3cyh)Homo sapiens
3cys, downloadSCOP (3cys)CATH (3cys)Homo sapiens
3ey6, downloadSCOP (3ey6)CATH (3ey6)Homo sapiens
3fap, downloadSCOP (3fap)CATH (3fap)Homo sapiens
3h9r, downloadSCOP (3h9r)CATH (3h9r)Homo sapiens
3i6c, downloadSCOP (3i6c)CATH (3i6c)Homo sapiens
3ich, downloadSCOP (3ich)CATH (3ich)Homo sapiens
3ici, downloadSCOP (3ici)CATH (3ici)Homo sapiens
3ik8, downloadSCOP (3ik8)CATH (3ik8)Homo sapiens
3ikd, downloadSCOP (3ikd)CATH (3ikd)Homo sapiens
3ikg, downloadSCOP (3ikg)CATH (3ikg)Homo sapiens
3jyj, downloadSCOP (3jyj)CATH (3jyj)Homo sapiens
3k0m, downloadSCOP (3k0m)CATH (3k0m)Homo sapiens
3k0n, downloadSCOP (3k0n)CATH (3k0n)Homo sapiens
3k0o, downloadSCOP (3k0o)CATH (3k0o)Homo sapiens
3k0p, downloadSCOP (3k0p)CATH (3k0p)Homo sapiens
3k0q, downloadSCOP (3k0q)CATH (3k0q)Homo sapiens
3k0r, downloadSCOP (3k0r)CATH (3k0r)Homo sapiens
3kab, downloadSCOP (3kab)CATH (3kab)Homo sapiens
3kac, downloadSCOP (3kac)CATH (3kac)Homo sapiens
3kad, downloadSCOP (3kad)CATH (3kad)Homo sapiens
3kaf, downloadSCOP (3kaf)CATH (3kaf)Homo sapiens
3kag, downloadSCOP (3kag)CATH (3kag)Homo sapiens
3kah, downloadSCOP (3kah)CATH (3kah)Homo sapiens
3kai, downloadSCOP (3kai)CATH (3kai)Homo sapiens
3kce, downloadSCOP (3kce)CATH (3kce)Homo sapiens
3lpy, downloadSCOP (3lpy)CATH (3lpy)Homo sapiens
3mdf, downloadSCOP (3mdf)CATH (3mdf)Homo sapiens
3mdy, downloadSCOP (3mdy)CATH (3mdy)Homo sapiens
3ntp, downloadSCOP (3ntp)CATH (3ntp)Homo sapiens
3o5d, downloadSCOP (3o5d)CATH (3o5d)Homo sapiens
3o5e, downloadSCOP (3o5e)CATH (3o5e)Homo sapiens
3o5f, downloadSCOP (3o5f)CATH (3o5f)Homo sapiens
3o5g, downloadSCOP (3o5g)CATH (3o5g)Homo sapiens
3o5i, downloadSCOP (3o5i)CATH (3o5i)Homo sapiens
3o5j, downloadSCOP (3o5j)CATH (3o5j)Homo sapiens
3o5k, downloadSCOP (3o5k)CATH (3o5k)Homo sapiens
3o5l, downloadSCOP (3o5l)CATH (3o5l)Homo sapiens
3o5m, downloadSCOP (3o5m)CATH (3o5m)Homo sapiens
3o5o, downloadSCOP (3o5o)CATH (3o5o)Homo sapiens
3o5p, downloadSCOP (3o5p)CATH (3o5p)Homo sapiens
3o5q, downloadSCOP (3o5q)CATH (3o5q)Homo sapiens
3o5r, downloadSCOP (3o5r)CATH (3o5r)Homo sapiens
3odi, downloadSCOP (3odi)CATH (3odi)Homo sapiens
3odk, downloadSCOP (3odk)CATH (3odk)Homo sapiens
3odl, downloadSCOP (3odl)CATH (3odl)Homo sapiens
3oob, downloadSCOP (3oob)CATH (3oob)Homo sapiens
3qyu, downloadSCOP (3qyu)CATH (3qyu)Homo sapiens
3r49, downloadSCOP (3r49)CATH (3r49)Homo sapiens
3r4g, downloadSCOP (3r4g)CATH (3r4g)Homo sapiens
3r54, downloadSCOP (3r54)CATH (3r54)Homo sapiens
3r56, downloadSCOP (3r56)CATH (3r56)Homo sapiens
3r57, downloadSCOP (3r57)CATH (3r57)Homo sapiens
3r59, downloadSCOP (3r59)CATH (3r59)Homo sapiens
3rcf, downloadSCOP (3rcf)CATH (3rcf)Homo sapiens
3rcg, downloadSCOP (3rcg)CATH (3rcg)Homo sapiens
3rci, downloadSCOP (3rci)CATH (3rci)Homo sapiens
3rck, downloadSCOP (3rck)CATH (3rck)Homo sapiens
3rcl, downloadSCOP (3rcl)CATH (3rcl)Homo sapiens
3rd9, downloadSCOP (3rd9)CATH (3rd9)Homo sapiens
3rda, downloadSCOP (3rda)CATH (3rda)Homo sapiens
3rdb, downloadSCOP (3rdb)CATH (3rdb)Homo sapiens
3rdc, downloadSCOP (3rdc)CATH (3rdc)Homo sapiens
3rdd, downloadSCOP (3rdd)CATH (3rdd)Homo sapiens
3tc5, downloadSCOP (3tc5)CATH (3tc5)Homo sapiens
3tcz, downloadSCOP (3tcz)CATH (3tcz)Homo sapiens
3tdb, downloadSCOP (3tdb)CATH (3tdb)Homo sapiens
3uch, downloadSCOP (3uch)CATH (3uch)Homo sapiens
3ui4, downloadSCOP (3ui4)CATH (3ui4)Homo sapiens
3ui5, downloadSCOP (3ui5)CATH (3ui5)Homo sapiens
3ui6, downloadSCOP (3ui6)CATH (3ui6)Homo sapiens
4cyh, downloadSCOP (4cyh)CATH (4cyh)Homo sapiens
4dh0, downloadSCOP (4dh0)CATH (4dh0)Homo sapiens
4dip, downloadSCOP (4dip)CATH (4dip)Homo sapiens
4drk, downloadSCOP (4drk)CATH (4drk)Homo sapiens
4drm, downloadSCOP (4drm)CATH (4drm)Homo sapiens
4drn, downloadSCOP (4drn)CATH (4drn)Homo sapiens
4dro, downloadSCOP (4dro)CATH (4dro)Homo sapiens
4drp, downloadSCOP (4drp)CATH (4drp)Homo sapiens
4drq, downloadSCOP (4drq)CATH (4drq)Homo sapiens
4fap, downloadSCOP (4fap)CATH (4fap)Homo sapiens
1fgl, downloadSCOP (1fgl)CATH (1fgl)Human immunodeficiency virus type 1 group M subtype B (isolate WMJ22)
1fd9, downloadSCOP (1fd9)CATH (1fd9)Legionella pneumophila
2uz5, downloadSCOP (2uz5)CATH (2uz5)Legionella pneumophila
1fd9, downloadSCOP (1fd9)CATH (1fd9)Legionella pneumophila (strain Corby)
2vcd, downloadSCOP (2vcd)CATH (2vcd)Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
2haq, downloadSCOP (2haq)CATH (2haq)Leishmania donovani
3bt8, downloadSCOP (3bt8)CATH (3bt8)Leishmania donovani
3eov, downloadSCOP (3eov)CATH (3eov)Leishmania donovani
2hqj, downloadSCOP (2hqj)CATH (2hqj)Leishmania major
1md5, downloadSCOP (1md5)CATH (1md5)Lupinus luteus
1cwa, downloadSCOP (1cwa)CATH (1cwa)Macaca mulatta
1cwb, downloadSCOP (1cwb)CATH (1cwb)Macaca mulatta
1cwc, downloadSCOP (1cwc)CATH (1cwc)Macaca mulatta
1cwj, downloadSCOP (1cwj)CATH (1cwj)Macaca mulatta
1cwk, downloadSCOP (1cwk)CATH (1cwk)Macaca mulatta
1cwl, downloadSCOP (1cwl)CATH (1cwl)Macaca mulatta
1mik, downloadSCOP (1mik)CATH (1mik)Macaca mulatta
2cyh, downloadSCOP (2cyh)CATH (2cyh)Macaca mulatta
2wlw, downloadSCOP (2wlw)CATH (2wlw)Macaca mulatta
3cyh, downloadSCOP (3cyh)CATH (3cyh)Macaca mulatta
3cys, downloadSCOP (3cys)CATH (3cys)Macaca mulatta
4cyh, downloadSCOP (4cyh)CATH (4cyh)Macaca mulatta
4dga, downloadSCOP (4dga)CATH (4dga)Macaca mulatta
4dgb, downloadSCOP (4dgb)CATH (4dgb)Macaca mulatta
4dgc, downloadSCOP (4dgc)CATH (4dgc)Macaca mulatta
4dgd, downloadSCOP (4dgd)CATH (4dgd)Macaca mulatta
4dge, downloadSCOP (4dge)CATH (4dge)Macaca mulatta
3pr9, downloadSCOP (3pr9)CATH (3pr9)Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
3pra, downloadSCOP (3pra)CATH (3pra)Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
3prb, downloadSCOP (3prb)CATH (3prb)Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
3prd, downloadSCOP (3prd)CATH (3prd)Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
1ix5, downloadSCOP (1ix5)CATH (1ix5)Methanococcus thermolithotrophicus
2rmc, downloadSCOP (2rmc)CATH (2rmc)Mus musculus
3kz7, downloadSCOP (3kz7)CATH (3kz7)Mus musculus
1w74, downloadSCOP (1w74)CATH (1w74)Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97), Mycobacterium tuberculosis
3gpk, downloadSCOP (3gpk)CATH (3gpk)Novosphingobium aromaticivorans (strain DSM 12444)
1bl4, downloadSCOP (1bl4)CATH (1bl4)Oryctolagus cuniculus
1cwa, downloadSCOP (1cwa)CATH (1cwa)Papio anubis
1cwb, downloadSCOP (1cwb)CATH (1cwb)Papio anubis
1cwc, downloadSCOP (1cwc)CATH (1cwc)Papio anubis
1cwj, downloadSCOP (1cwj)CATH (1cwj)Papio anubis
1cwk, downloadSCOP (1cwk)CATH (1cwk)Papio anubis
1cwl, downloadSCOP (1cwl)CATH (1cwl)Papio anubis
1mik, downloadSCOP (1mik)CATH (1mik)Papio anubis
2cyh, downloadSCOP (2cyh)CATH (2cyh)Papio anubis
3cyh, downloadSCOP (3cyh)CATH (3cyh)Papio anubis
3cys, downloadSCOP (3cys)CATH (3cys)Papio anubis
4cyh, downloadSCOP (4cyh)CATH (4cyh)Papio anubis
1qng, downloadSCOP (1qng)CATH (1qng)Plasmodium falciparum
1qnh, downloadSCOP (1qnh)CATH (1qnh)Plasmodium falciparum
2ofn, downloadSCOP (2ofn)CATH (2ofn)Plasmodium falciparum (isolate 3D7)
2vn1, downloadSCOP (2vn1)CATH (2vn1)Plasmodium falciparum (isolate 3D7)
3pa7, downloadSCOP (3pa7)CATH (3pa7)Plasmodium vivax (strain Salvador I)
1z81, downloadSCOP (1z81)CATH (1z81)Plasmodium yoelii yoelii
3oe2, downloadSCOP (3oe2)CATH (3oe2)Pseudomonas syringae pv. tomato (strain DC3000)
1ist, downloadSCOP (1ist)CATH (1ist)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
1vdn, downloadSCOP (1vdn)CATH (1vdn)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
3uf8, downloadSCOP (3uf8)CATH (3uf8)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
3uqa, downloadSCOP (3uqa)CATH (3uqa)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
3uqb, downloadSCOP (3uqb)CATH (3uqb)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
3vaw, downloadSCOP (3vaw)CATH (3vaw)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
4fn2, downloadSCOP (4fn2)CATH (4fn2)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
4g50, downloadSCOP (4g50)CATH (4g50)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
4ggq, downloadSCOP (4ggq)CATH (4ggq)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
4giv, downloadSCOP (4giv)CATH (4giv)Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
1kt1, downloadSCOP (1kt1)CATH (1kt1)Saimiri boliviensis boliviensis
2ck1, downloadSCOP (2ck1)CATH (2ck1)Schistosoma mansoni
2cmt, downloadSCOP (2cmt)CATH (2cmt)Schistosoma mansoni
1wvs, downloadSCOP (1wvs)CATH (1wvs)Schizosaccharomyces pombe (strain 972 / ATCC 24843)
3b09, downloadSCOP (3b09)CATH (3b09)Shewanella sp. SIB1
2jzv, downloadSCOP (2jzv)CATH (2jzv)Staphylococcus aureus (strain Mu50 / ATCC 700699)
3cgm, downloadSCOP (3cgm)CATH (3cgm)Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
3cgn, downloadSCOP (3cgn)CATH (3cgn)Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
3luo, downloadSCOP (3luo)CATH (3luo)Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
3jxv, downloadSCOP (3jxv)CATH (3jxv)Triticum aestivum
2lj4, downloadSCOP (2lj4)CATH (2lj4)Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
1jvw, downloadSCOP (1jvw)CATH (1jvw)Trypanosoma cruzi
1xq7, downloadSCOP (1xq7)CATH (1xq7)Trypanosoma cruzi (strain CL Brener)

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
9000-Legionella pneumophila-gel filtration2527
1100016000Zea mays-cytosolic enzyme form, gel filtration on various matrices2535
12440-Mycoplasma genitalium-peptidylprolyl isomerase domain, N-terminal sequence analysis651071
17600-Bacillus subtilis-cyclophilin649837
20000-Spinacia oleraceaP82536-651323
42000-Methanothermococcus thermolithotrophicusO52980gel filtration2525
47300-Bacillus subtilis-trigger factor649837
52330-Mycoplasma genitalium-trigger factor, N-terminal sequence analysis651071
65000-Bacillus subtilis-the cross-linking of cells expressing either wild-type PrsA or PrsA-Myc revealed, in addition to the 33 kDa PrsA or PrsA-Myc monomers, two other PrsA-containing bands of higher molecular weights, one migrating (in SDS-PAGE) at approximately 65 kDa and the other one slightly above it (about 68 kDa)716254
68000-Bacillus subtilis-the cross-linking of cells expressing either wild-type PrsA or PrsA-Myc revealed, in addition to the 33 kDa PrsA or PrsA-Myc monomers, two other PrsA-containing bands of higher molecular weights, one migrating (in SDS-PAGE) at approximately 65 kDa and the other one slightly above it (about 68 kDa)716254

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
?Neurospora crassa-x * 20000, mitochondrial form, SDS-PAGE2514
?Bos taurus--2516
?Homo sapiens-x * 17000, SDS-PAGE; x * 17737, calculation from amino acid sequence2516
?Saccharomyces cerevisiae-x * 16500, enzyme form PPI-II, SDS-PAGE; x * 17200, enzyme form PPI-III, SDS-PAGE2521
?Methanothermococcus thermolithotrophicusO52980x * 16000, SDS-PAGE2525
?Homo sapiens--2527
?Legionella pneumophila-x * 17968, calculation from nucleotide sequence2527
?Rattus norvegicus-x * 18000, cytosolic isoforms, SDS-PAGE; x * 22000, microsomal isoform2532
?Escherichia coli-x * 18137, cationic enzyme form, calculation from amino acid sequence; x * 18181, calculation from amino acid sequence2533
?Bos taurus-x * 20600, SDS-PAGE2536
?Rattus norvegicus-x * 17000, cytosolic enzyme form, SDS-PAGE; x * 18600, major mitochondrial enzyme form, SDS-PAGE2537
?Geobacillus stearothermophilus-x * 18000, SDS-PAGE2550
?Plasmodium falciparum-x * 19000, SDS-PAGE2555
?Triticum aestivum-x * 77000, SDS-PAGE653500
?Solanum lycopersicum-x * 18000, SDS-PAGE653605
?Mycobacterium tuberculosisP65762x * 19200, calculated661643
?Rickettsia prowazekiiQ9ZCX6x * 29500, SDS-PAGE, enzyme heated in sample buffer to 100°C migrates electrophoretically slower than untreated enzyme, x * 30819, electrospray mass spectrometry661913
?Plasmodium falciparum-x * 34800, calculated662803
?Neisseria gonorrhoeae-x * 28908, calculated662909
?Haemonchus contortusQ4G338x * 32500, SDS-PAGE and predicted663015
?Trypanosoma cruziQ2I5R9x * 13000, SDS-PAGE681821
?Chlamys farreriQ6USC1x * 17700, calculated694097
?Ricinus communisQ8VX73x * 18154, calculated, x * 22000, SDS-PAGE694779
?Haemaphysalis longicornisB2ZWT4, B2ZWT5x * 20100, calculated, x * 24000, SDS-PAGE; x * 23500, calculated for mature protein, x * 23500, SDS-PAGE694932
?Lupinus luteusO49886x * 18000, SDS-PAGE of recombinant enzyme694993
?Bombyx moriB2LU30x * 21474, sequence calculation701596
?Homo sapiens, Rattus norvegicus-x * 18000, about704154
?Homo sapiens, Mus musculus-x * 14000, about, SDS-PAGE705715
?Trypanosoma cruziB8XP93x * 45400, calculated from amino acid sequence714320
dimerEscherichia coli-245-residue subunit is divided into two domains, the overall form of the dimer is V-shaped, and the two C-terminal domains are located at the extremities of the V652932
dimerBordetella pertussisP404152 * 27000, SDS-PAGE, 2 * 27034, calculated693627
dimerBordetella pertussis-Par27 is the first identified parvulin protein that forms dimers in solution. Par27 is a tripartite protein with a central PPIase domain surrounded by N- and C-terminal sub-domains, NTD and CTD. Par27 structure analysis by X-ray crystallography, small-angle X-ray scattering and template-based modeling, rigid-body modeling, overview705408
monomerGallus gallus-x * 68000, SDS-PAGE under reducing conditions and under nonreducing conditions2522
oligomerBacillus subtilis-x * 33000, SDS-PAGE716254
trimerEscherichia coli-gel filtration and analytical ultracentrifugation716907
monomerZea mays-1 * 17500, cytosolic enzyme form, SDS-PAGE; 1 * 17700, microsomal enzyme form, SDS-PAGE2535
additional informationHomo sapiens-PPIase domain and WW domain show weak interaction at their interface in solution, The flexible linker, connecting both domains, potomes binding652417
additional informationHomo sapiens-tertiary structure of hPAR14 is determined by nuclear magnetic resonance spectroscopy652844
additional informationHomo sapiens-the peptidylprolyl isomerase Cyp40, FKBP51 and FKBP52 are components of the Hsp90 chaperone complex. The peptidylprolyl isomerase monomers bind to a Hsp90 dimer. The three isomerase differ both in their affinity for Hsp90 and their chaperone activity suggesting that they play distinct roles in the Hsp90 chaperone complex652854
additional informationArabidopsis thaliana-solution structure determined by three-dimensional nuclear magnetic resonance spectroscopy652891
additional informationMethanothermococcus thermolithotrophicus-three-dimensional solution structure. The IF domain is a novel-folding motif and exposes a hydrophobic surface, which is considered to play an important role in the chaperone-like activity652911
additional informationHomo sapiens-consists of two RNA binding domains at the N-terminus and a peptidylprolyl isomerase domain at the C-terminus660910
additional informationRickettsia prowazekiiQ9ZCX6N-terminal sequence661913
additional informationOryctolagus cuniculus-isoform Cyp-A exists in native heterocomplexes containing cytoplasmic dynein. Enzyme activity is not required for formation of dynein complexes. Binding to dynamitin is dependent on peptidylprolyl isomerase domain. Heterocomplexes containing tubulin and dynein can be formed in cytosol under microtubule-stabilizing conditions662319
additional informationHaemonchus contortusQ4G338protein consists of a N-terminal RNA recognition motif and a C-terminal cyclophilin domain663015
additional informationEscherichia coliP0A9L5structure analysis by multidimensional solution-state NMR spectroscopy, model of substrate binding pocket, comparison with human and plant proteins663328
additional informationHomo sapiens-isoform Pin1 forms a complex with inhibitor of apoptosis protein, Survivin678442
additional informationHomo sapiens-enzyme interacts with SNW1/SKI-binding protein and with stathmin679270
additional informationHomo sapiensQ9Y3C6isoform PPIL1 stably associates with SKIP, an essential component of 45S activated spliceosome. Dissociation constant is 1.25e -7 M for the N-terminal peptide of SKIP with PPIL1680652
additional informationHomo sapiensQ14318isoform FKBP38 interacts with prolyl-4-hydroxylase domain-containing enzyme PHD2 by association of their N-terminal regions. FKBP38 does not interact with PHD1 or PHD3. Depletion of FKBP38 by RNAi results in increased PHD2 hydroxylation activity and decreased protein levels of PHD2 substrate HIF. downregulation of FKBP38 does not affect PHD2 mRNA levels, but prolongs PHD2 protein stability681919
additional informationHomo sapiens-isoform Pin1 is a critical regulator of p27kip1 through inhibition of Forkhead box O, FOXO4. Oxidative stress induces binding of Pin1 to FOXO4 thereby attenuating its monoubiquitination. Pin1 prevents nuclear FOXO4 accumulation and acts on FOXO through stimulation of the activity of the deubiquitinating enzyme HAUSP/USP7691625
additional informationEscherichia coli-PpiD interacts with misfolded proteins such as scrambled ribonuclease A or with D-somatostatin, with the amino acid sequence AGSKNFFWKTFTSS and derived model peptides692303
additional informationRattus norvegicus-CypB interacts with the endoplasmic reticulum stress-related chaperones, Bip and Grp94693310
additional informationBordetella pertussisP40415isoform Par27 binds to an unfolded filamentous hemagglutinin fragment693627
additional informationHomo sapiens-isoform Pin1 interacts with brain-specifc protein BNIP-H after nerve growth factor stimulation. Both proteins co-localize in the neurites and cytosol of differentiating pheochromocytoma PC12 cells and the embryonic carcinoma P19 cells. Expression of Pin1 disrupts the BNIP-H/glutaminase complex formation in PC-12 cells under nerve growth factor-stimulation694818
additional informationLupinus luteusO49886recombinant enzyme is able to interact with nucleic acids, both single and double stranded DNA fragments as well as RNA694993
additional informationBombyx moriB2LU30peptide mass fingerprinting and mass spectrometric analysis, homology-modeling701596
additional informationHomo sapiens, Rattus norvegicus-the N-terminal WW domain is connected by a linker to the C-terminal catalytic isomerase domain, structure modeling, overview704154
additional informationBordetella pertussis-the variability in the orientation of the PPIase domains relative to the NTD/CTD core platform, inter-domain flexibility can be important for the biological activity of this protein. Small angle X-ray and neutron scattering, molecular dynamics simulation, and homology modeling, overview705408

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
proteolytic modificationHaemaphysalis longicornisB2ZWT4, B2ZWT5sequence contains a putative signal peptide cleavage site between residues S19 and A20694932
phosphoproteinHomo sapiens-phosphorylated at Ser19 in vivo and in vitro. In human HeLa cells the protein is most likely modified by casein kinase 2652918
lipoproteinNeisseria gonorrhoeae--662909
glycoproteinPlasmodium falciparum-N-glycosylated, probably at two sites in vitro2534
proteolytic modificationBordetella pertussisP40415sequence contains a N-terminal signal peptide, with a putative cleavage site between residues A19 and Q20693627
additional informationBrassica napus-gene encodes mature protein lacking transit peptide653605
glycoproteinRattus norvegicus-microsomal isoform2532
additional informationSchistosoma mansoniQ26548mechanism for regulation of isoform cyclosporin A activity via oxidation of its thiol groups at C122 and C126, oxidized enzyme is inactive, whereas the reduced enzyme is an efficient isomerase680801
additional informationSolanum lycopersicum, Zea mays-gene encodes mature protein lacking transit peptide653605

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
2.0 A resolution. Computational model and comparison with human enzymeAcanthamoeba polyphaga MimivirusQ5UP71693639
purified recombinant His-tagged and SeMet-labeled enzyme, X-ray diffraction structure determination and analysis at 2.2-2.3 A resolution, homology modelingBordetella pertussis-705408
hanging-drop vapour-diffusion method, CYP-5, X-ray structure solved to a resolution of 1.75 ACaenorhabditis elegansP52014652894
two crystal forms are grown, hanging-drop vapour-diffusion method, solved to a resolution of 1.8 ACaenorhabditis elegans-651964
NMR-study of enzyme and its complexes with substrates RNase A and reduced carboxymethylated bovine alpha-lactalbumin in solution. Molecular model of chaperone activity of enzymeEscherichia coli-678149
three different forms: 1. crystals of the full length native molecule are obtained by sitting drop vapour diffusion method, 2. crystals of the truncated form lacking the last 21 residues are obtained by hanging drop vapour diffusion method 3. crystals of the truncated form lacking the last 21 residues in complex with the immunosuppressant ligand, FK506, are obtained by hanging drop vapour diffusion methodEscherichia coli-652932
-Homo sapiens-2546
1.65 A resolution. The N-terminus of one isomerase domain is bound in the active site of a neighbouring isomerase molecule in a manner analogous to the substrate. This sequence binds to the active site of the enzyme, but cannot be turned overHomo sapiensQ96BP3692291
2.0 A resolution, space group P3121; recombinant enzymeHomo sapiensQ9H2H8660626
crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide, hanging drop vapour diffusion methodHomo sapiens-652921
crystal structure of cyclophilin A bound to the amino-terminal domain of HIV-1 capsidHomo sapiens-2541
crystal structure of cyclophilin A complexed with a binding site peptide from HIV-1 capsid proteinHomo sapiens-2540
crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]4,4-dimethylthreonine cyclosporin AHomo sapiens-2542
crystallization of cyclophilin-tetrapeptide and cyclophilin-cyclosporin complexesHomo sapiens-2548
hanging drop vapor diffusion method, using 25% (w/v) PEG MME 550, 0.1 M zinc acetate, 0.1 M MES at pH 6.5; mutant K125A/E126A is crystallized by the hanging drop vapor diffusion method, using 2 M NH4SO4, 0.2 M NaCl, 0.1 M HEPES, pH 7.5; sitting drop vapor diffusion method, using 20% (w/v) PEG 3350 and 0.2 M NaI; sitting drop vapor diffusion method, using 34% (w/v) PEG 8K, 0.2 M NH4SO4, and 0.1 M bis-Tris, pH 6.0Homo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9716659
in complex with inhibitor 1-[(1R,10S)-3,8-dioxa-14-azabicyclo[8.3.1]tetradec-14-yl]-3,3-dimethyl-1-oxopentan-2-oneHomo sapiensP62942678718
in complex with inhibitor 4-phenyl-1-(3-pyridin-3-ylpropyl)butyl (2R)-1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate. Fluorine atoms of inhibitor participate in discrete interactions with the Phe36 phenyl ring and the Tyr26 hydroxyl group of enzyme, with the latter resembling a moderate-to-weak hydrogen bondHomo sapiens-682235
in complex with inhibitors (1R)-1,3-diphenyl-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylate, (1S)-1-cyclohexyl-3-phenylpropyl (2R)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate, (24aS)-17,17-dimethylhexadecahydropyrido[2,1-c][1,9,4]dioxazacyclohenicosine-1,14,18,19(3H,21H)-tetroneHomo sapiens-680340
mutant P9Q/R13F/K17V/R18F in complex with 1-(pyridin-4-ylthio)bicyclo[3.3.1]nonan-3-oneHomo sapiens-678716
recombinant enzyme expressed in Escherichia coliHomo sapiens-660614
recombinant protein, overall structure and analysis of cyclosporin A binding siteHomo sapiens-660910
solution structure of protein determined by NMR spectroscopyHomo sapiensQ9Y3C6680652
structure of human cyclophilin and its binding site for cyclophilin A determined by X-ray crystallography and NMR spectroscopyHomo sapiens-2547
X-ray structure of a decameric cyclophilin-cyclosporin crystal complexHomo sapiens-2545
X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1 A resolutionHomo sapiens-2543
crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin AMus musculus-2544
recombinant enzymeMycobacterium tuberculosisP65762661643
enzyme in reduced and oxidized state at 1.5 and 1.8 A resolution. Oxidized enzyme contains a disulfide bridge between C-terminal cysteines C122 and C126Schistosoma mansoniQ26548680801

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
6-Geobacillus stearothermophilus-60°C, 30 min, 50% loss of activity2550
78Geobacillus stearothermophilus-60°C, 30 min, stable2550
9-Geobacillus stearothermophilus-60°C, 30 min, about 60% loss of activity2550

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
50-Sus scrofa-unstable at2511
56-Escherichia coli-30 min, cationic enzyme form, no loss of activity2533
62-Geobacillus stearothermophilus-30 min, stable2550
65-Geobacillus stearothermophilus-30 min, 50% loss of activity2550
70-Geobacillus stearothermophilus-30 min, complete loss of activity2550
90-Methanothermococcus thermolithotrophicusO52980half-life: 90 min2525
100-Methanothermococcus thermolithotrophicusO52980half-life: 30 min2525

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
activity is abolished by incubation with trypsinSus scrofa-2511
about 80% of activity is lost on freezing the purified microsomal enzyme in liquid N2 and thawingZea mays-2535

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
native enzyme partially by chlorplast thylakoid preparationArabidopsis thalianaQ9SCY2706176
recombinant C-terminally His-tagged Par27 by nickel affinty chromatography and gel filtration to homogeneityBordetella pertussis-705408
-Bos taurus-2536
-Caenorhabditis elegans-651964, 652239
CYP-5Caenorhabditis elegansP52014652894
-Escherichia coli-2538
HighTrap Ni-chelating column chromatographyEscherichia coli-716907
Ni-NTA-agarose column chromatography and Superdex 75 gel filtrationEscherichia coli-715653
partialEscherichia coli-2513
-Geobacillus stearothermophilus-2550
-Homo sapiens-2516, 2519, 716069
3 isoforms: CyP1, CyP2, CyP3Homo sapiens-2531
glutathione-Sepharose 4B column chromatographyHomo sapiens-715609
glutathione-Sepharose column chromatography and S-Sepharose column chromatographyHomo sapiens-715863
Ni-NTA resin column chromatography and Superdex 200 gel filtration; Ni-NTA resin column chromatography and Superdex 200 gel filtration; Ni-NTA resin column chromatography and Superdex 200 gel filtration; Ni-NTA resin column chromatography and Superdex 200 gel filtration; Ni-NTA resin column chromatography and Superdex 200 gel filtration; Ni-NTA resin column chromatography and Superdex 200 gel filtration; Ni-NTA resin column chromatography and Superdex 200 gel filtration; Ni-NTA resin column chromatography and Superdex 200 gel filtration; Ni-NTA resin column chromatography and Superdex 200 gel filtrationHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9716659
recombinant enzyme and mutant P16SHomo sapiens-691452
recombinant GST-tagged enzyme from Escherichia coliHomo sapiens-705715
recombinant MBP-Pin1 fusion protein from Escherichia coli strain BL21(DE3) by amylose affinity chromatographyHomo sapiens-705066
-Legionella pneumophila-2527
recombinant enzymeLupinus luteusO49886694993
-Methanothermococcus thermolithotrophicusO529802525
-Mycoplasma genitalium-651071
-Neurospora crassa-2514
-Onchocerca volvulusQ8IA80652239
-Plasmodium falciparum-2534, 2555
-Rattus norvegicus-2532, 2537
-Saccharomyces cerevisiae-2524, 2526
3 molecular forms: PPI-I, PPI-II, and PPI-IIISaccharomyces cerevisiae-2521
isoform CYP3Saccharomyces cerevisiae-2528
-Schistosoma mansoni-2552, 2553
-Sus scrofa-2510, 2511, 2517
partialSus scrofa-2508
Ni-NTA agarose column chromatography and Superdex 75 gel filtrationTrypanosoma cruziB8XP93714320
-Vicia faba-653459

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-Bacillus subtilis-716254
gene PPIB, DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21 (DE3)Bombyx moriB2LU30701596
expression of the C-terminally His-tagged Par27Bordetella pertussis-705408
-Caenorhabditis elegans-651964, 652239
gene cj0596, expression of His-tagged Cj0596 protein in Escherichia coli strain BL21(DE3). Quantitative real-time reverse transcription PCR expression analysis of wild-type enzyme and revertant mutant, overviewCampylobacter jejuni-702908
-Escherichia coli-2538
mutant enzyme C69AEscherichia coli-649847
the N-terminal domain of peptidyl-prolyl isomerase SlyD (residues 1-165) is expressed in Escherichia coli BL21(DE3) cellsEscherichia coli-716907
expression in Escherichia coli, His-tag; expression in Escherichia coli, His-tagHaemaphysalis longicornisB2ZWT4, B2ZWT5694932
-Haemonchus contortusQ4G338663015
-Homo sapiens-716069
3 isoforms expressed in Escherichia coliHomo sapiens-2531
co-expression with TRPV6 channel protein in Xenopus laevis oocytesHomo sapiens-693077
expressed in Escherichia coli BL21 cellsHomo sapiens-715863
expressed in Escherichia coli BL21 Gold DE3 cells; expressed in Escherichia coli BL21 Gold DE3 cells; expressed in Escherichia coli BL21 Gold DE3 cells; expressed in Escherichia coli BL21 Gold DE3 cells; expressed in Escherichia coli BL21 Gold DE3 cells; expressed in Escherichia coli BL21 Gold DE3 cells; expressed in Escherichia coli BL21 Gold DE3 cells; expressed in Escherichia coli BL21 Gold DE3 cells; expressed in Escherichia coli BL21 Gold DE3 cellsHomo sapiensO43447, P23284, P30405, P45877, Q08752, Q13427, Q6UX04, Q9UNP9716659
expressed in Escherichia coli JM105 cellsHomo sapiens-715609
expression in 293-T cellsHomo sapiens-694818
expression in Escherichia coliHomo sapiens-2519, 2539, 652417, 660626, 691452
expression in T47D cell, MCF-7 cell, MDA-231 cellHomo sapiens-691626
expression of GST-tagged Pin1Homo sapiens-705286
expression of MBP-Pin1 fusion protein in Escherichia coli strain BL21(DE3)Homo sapiens-705066
neutral isoelectric formHomo sapiens-2530
Par14, sequence comparisons, expression of GST-tagged enzyme in Escherichia coliHomo sapiens-705715
wild-type and mutant enzymes W121A, H54Q, R55A, F60A, Q111A, F133A, and H126Q, expressed in Escherichia coliHomo sapiens-2596
-Legionella pneumophila-2527
expression in Escherichia coliLupinus luteusO49886694993
-Methanothermococcus thermolithotrophicusO529802525
expression in Escherichia coliMycoplasma genitalium-651071
-Neurospora crassa-2514
-Onchocerca volvulusQ8IA80652239
isolation of cDNAOryza sativaQ40672, Q40673653484
-Plasmodium falciparum-662803
expression in Escherichia coliPlasmodium falciparum-2534, 2555
expression in H9C2 cellRattus norvegicus-693310
expression in Escherichia coli, His-tagRicinus communisQ8VX73694779
-Saccharomyces cerevisiae-2526
cyclophilin A and B, expression in Escherichia coliSaccharomyces cerevisiae-2524
isoform CYP3Saccharomyces cerevisiae-2528
enzyme form SmCYP A ans SmCYP B expressed in bacterial cells as histidine-binding fusion proteins and as maltose-binding fusion proteins and also as nonfused proteins. Expression in Sf9 insect cells in their natural formsSchistosoma mansoni-2552
overexpression as a fusion protein with Schistosoma japonicum EC 2.5.1.18 in Escherichia coliSchistosoma mansoni-2553
expression in Escherichia coliSolanum lycopersicum-653605
-Trypanosoma cruziQ2I5R9681821
expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cellsTrypanosoma cruziB8XP93714320
expression in Escherichia coliVicia faba-653459
expression in Escherichia coliZea mays-653563

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
the enzyme is upregulated in cancer cellsHomo sapiens-703021
Pin1 expression is enhanced in transformed T-cell lines C8166-45, MT4, and JPX9 expressing oncoprotein Tax from human T-cell leukemia virus type 1Homo sapiens-705427
the overexpression of Pin1 in Hep-G2 cells markedly enhances insulin-induced IRS-1 phosphorylation and its downstream events: phosphatidylinositol 3-kinase binding with IRS-1andAkt phosphorylationHomo sapiens-715609
Pin1 expression is increased by NS5B proteinHomo sapiens-716069
the overexpression of Pin1 in Hep-G2 cells markedly enhances insulin-induced IRS-1 phosphorylation and its downstream events: phosphatidylinositol 3-kinase binding with IRS-1andAkt phosphorylation. Pin1 expression is up-regulated in accordance with nutrient conditions such as food intake or a high-fat dietMus musculus-715609
genes surA and fkpA are not carbon energy source-starvation inducible, and their expression during C-starvation does not appear to be sigmaE-dependent, overviewSalmonella enterica subsp. enterica serovar Typhimurium-701755

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
C129SArabidopsis thalianaP34791presence of dithiothreitol, 49% of wild-type activity, presence of H2O2, 84% of wild-type activity678048
C171SArabidopsis thalianaP34791presence of dithiothreitol, 25% of wild-type activity, presence of H2O2, 87% of wild-type activity678048
C176SArabidopsis thalianaP34791presence of dithiothreitol, 94% of wild-type activity, presence of H2O2, 231% of wild-type activity678048
C69AEscherichia coli-about one equivalent of 5-hydroxy-1,4-naphthoquinone results in complete inactivation of the mutant enzyme compared to two equivalent for the wild-type enzyme649847
E178VEscherichia coli-slightly more active than wild-type enzyme with succinyl-Ala-Phe-Pro-Phe-4-nitroanilide, as active as wild-type enzyme in refolding of reduced and carboxymethylated RNAse T1, chaperone activity comparable with wild-type, not impaired in association with nascent proteins652525
F198AEscherichia coli-inactive with succinyl-Ala-Phe-Pro-Phe-4-nitroanilide, inactive in refolding of reduced and carboxymethylated RNAse T1, chaperone activity comparable with wild-type, not impaired in association with nascent proteins652525
F233LEscherichia coli-inactive with succinyl-Ala-Phe-Pro-Phe-4-nitroanilide, less active than wild-type enzyme in refolding of reduced and carboxymethylated RNAse T1, chaperone activity comparable with wild-type, not impaired in association with nascent proteins652525
G148DEscherichia coli-the FkpA313 mutant protein, which contains a G148D replacement in the PPIase domain, shows only a very low in vitro PPIase activity with both peptides (the activity amounts to 0.4 and 0.2% that of wild type enzyme)715653
I42SEscherichia coli-about 50% of wild-type peptidylprolyl isomerase activity, cells show moderate deficiency in nickel uptake under anaerobic conditions680509
A16SHomo sapiens-site-directed mutagenesis, dominant-negative Pin1 point mutation705286
C113AHomo sapiens-mutation in isomerase domain, catalytically inert. Mutation diminishes binding to brain-specifc protein BNIP-H694818
C113AHomo sapiens-isomerase-inactive716069
C113DHomo sapiens-mutation does not compromise isoform Pin1 function in vivo nor does it abolish catalytic activity. C113 may not be the catalytic nucleophile681404
C113SHomo sapiens-decrease in kcat, small in Km value. C113 may not be the catalytic nucleophile681404
C113SHomo sapiens-catalytically inactive715712
C115AHomo sapiens-Cys at position 52, 62, 115, and 161 are mutated individually to Ala and the purified mutant proteins to retain full affinity for cyclosporin A and equivalent catalytic efficiency as a rotamase2539
C161AHomo sapiens-Cys at position 52, 62, 115, and 161 are mutated individually to Ala and the purified mutant proteins to retain full affinity for cyclosporin A and equivalent catalytic efficiency as a rotamase2539
C52AHomo sapiens-Cys at position 52, 62, 115, and 161 are mutated individually to Ala and the purified mutant proteins to retain full affinity for cyclosporin A and equivalent catalytic efficiency as a rotamase2539
C62AHomo sapiens-Cys at position 52, 62, 115, and 161 are mutated individually to Ala and the purified mutant proteins to retain full affinity for cyclosporin A and equivalent catalytic efficiency as a rotamase2539
D155RHomo sapiens-mutant enzyme has intact isomerase activity and cyclosporin A-binding activity. When complexed to cyclosporin A, the mutant enzyme displays only reduced affinity for calcineurin and much decreased inhibition of calcineurin phosphatase activity653828
D158RHomo sapiens-mutant enzyme has intact isomerase activity and cyclosporin A-binding activity. When complexed to cyclosporin A, the mutant enzyme displays only reduced affinity for calcineurin and much decreased inhibition of calcineurin phosphatase activity653828
DELTA208-213Homo sapiens-dramatic reduction of peptidylprolyl isomerase activity and 400fold reduction of protein phosphatase 2A activation662459
F133AHomo sapiens-mutant enzymes W121A, H54Q, R55A, F60A, Q111A, F133A, and H126Q. Mutants enzymes H54Q, Q111A, F113A, and W121A retain 3-15% of the catalytic efficiency of the wild-type recombinant enzyme. The mutants R55A, F60A and H126Q, each retain less than 1% of the wild-type recombinant catalytic efficiency. The wild-type enzyme and the mutants R55A, F60A, F113A, and H126Q inhibit calcineurin in the presence of cyclosporin A, whereas W121A does not2596
F60AHomo sapiens-mutant enzymes W121A, H54Q, R55A, F60A, Q111A, F133A, and H126Q. Mutants enzymes H54Q, Q111A, F113A, and W121A retain 3-15% of the catalytic efficiency of the wild-type recombinant enzyme. The mutants R55A, F60A and H126Q, each retain less than 1% of the wild-type recombinant catalytic efficiency. The wild-type enzyme and the mutants R55A, F60A, F113A, and H126Q inhibit calcineurin in the presence of cyclosporin A, whereas W121A does not2596
G77HHomo sapiens-mutant enzyme has intact isomerase activity and cyclosporin A-binding activity. When complexed to cyclosporin A, the mutant enzyme displays only reduced affinity for calcineurin and much decreased inhibition of calcineurin phosphatase activity653828
H126QHomo sapiens-mutant enzymes W121A, H54Q, R55A, F60A, Q111A, F133A, and H126Q. Mutants enzymes H54Q, Q111A, F113A, and W121A retain 3-15% of the catalytic efficiency of the wild-type recombinant enzyme. The mutants R55A, F60A and H126Q, each retain less than 1% of the wild-type recombinant catalytic efficiency. The wild-type enzyme and the mutants R55A, F60A, F113A, and H126Q inhibit calcineurin in the presence of cyclosporin A, whereas W121A does not2596
H157AHomo sapiens-mutant supports viability in yeast complementation assay690907
H157FHomo sapiens-mutant supports viability in yeast complementation assay690907
H157LHomo sapiens-mutant supports viability in yeast complementation assay690907
H157NHomo sapiens-mutant supports viability in yeast complementation assay690907
H157SHomo sapiens-mutant supports viability in yeast complementation assay690907
H47QHomo sapiens-mutant enzymes W121A, H54Q, R55A, F60A, Q111A, F133A, and H126Q. Mutants enzymes H54Q, Q111A, F113A, and W121A retain 3-15% of the catalytic efficiency of the wild-type recombinant enzyme. The mutants R55A, F60A and H126Q, each retain less than 1% of the wild-type recombinant catalytic efficiency. The wild-type enzyme and the mutants R55A, F60A, F113A, and H126Q inhibit calcineurin in the presence of cyclosporin A, whereas W121A does not2596
H59AHomo sapiens-mutant supports viability in yeast complementation assay690907
H59FHomo sapiens-mutant supports viability in yeast complementation assay but displays significantly reduced growth in yeast compared to wild-type Pin1690907
H59LHomo sapiens-mutant is not viable690907
H59L/H157AHomo sapiens-about 50% of wild-type activity with substrate Trp-Phe-Tyr-Ser(PO3H2)-(cis)-Pro-Arg-4-nitroanilide, no activity with substrate Ala-Glu-(cis)-Pro-Phe-4-nitroanilide690907
H59L/H157FHomo sapiens-about 5% of wild-type activity with substrate Trp-Phe-Tyr-Ser(PO3H2)-(cis)-Pro-Arg-4-nitroanilide, 3% activity with substrate Ala-Glu-(cis)-Pro-Phe-4-nitroanilide690907
H59L/H157LHomo sapiens-mutant supports viability in yeast complementation assay, mutation H157L rescues mutant H59L690907
H59L/H157SHomo sapiens-about 5% of wild-type activity with substrate Trp-Phe-Tyr-Ser(PO3H2)-(cis)-Pro-Arg-4-nitroanilide, no activity with substrate Ala-Glu-(cis)-Pro-Phe-4-nitroanilide690907
H59NHomo sapiens-mutant supports viability in yeast complementation assay690907
H59SHomo sapiens-mutant supports viability in yeast complementation assay690907
K63AHomo sapiens-decrease in kcat, increase in Km value681404
P16SHomo sapiens-10fold decrease in ratio kcat/Km at 10°C. Mutant is extremely sensitive to guanidinium-HCl and shows increased susceptibility to urea. Folding time of the mutant is extended691452
P9Q/R13F/K17V/R18FHomo sapiens-mutant designed for crytallizability, crystal structure in complex with 1-(pyridin-4-ylthio)bicyclo[3.3.1]nonan-3-one678716
Q111AHomo sapiens-mutant enzymes W121A, H54Q, R55A, F60A, Q111A, F133A, and H126Q. Mutants enzymes H54Q, Q111A, F113A, and W121A retain 3-15% of the catalytic efficiency of the wild-type recombinant enzyme. The mutants R55A, F60A and H126Q, each retain less than 1% of the wild-type recombinant catalytic efficiency. The wild-type enzyme and the mutants R55A, F60A, F113A, and H126Q inhibit calcineurin in the presence of cyclosporin A, whereas W121A does not2596
R55AHomo sapiens-mutant enzymes W121A, H54Q, R55A, F60A, Q111A, F133A, and H126Q. Mutants enzymes H54Q, Q111A, F113A, and W121A retain 3-15% of the catalytic efficiency of the wild-type recombinant enzyme. The mutants R55A, F60A and H126Q, each retain less than 1% of the wild-type recombinant catalytic efficiency. The wild-type enzyme and the mutants R55A, F60A, F113A, and H126Q inhibit calcineurin in the presence of cyclosporin A, whereas W121A does not2596
R68/69AHomo sapiens-catalytically inactive715712
R68A/R69AHomo sapiens-decrease in both kcat and Km value681404
S16AHomo sapiens-mutation in WW domain. Mutation diminishes binding to brain-specifc protein BNIP-H694818
S16AHomo sapiens-a dominant negative mutant704154
S16AHomo sapiens-isomerase-inactive716069
S16A/Y23AHomo sapiens-the mutations of Pin1 protein do not affect the structure of Pin1 but abolishes the ability of the WW domain to bind pSer/pThr-Pro ligands705066
S16EHomo sapiens-mutation in WW domain. Mutation diminishes binding to brain-specifc protein BNIP-H694818
S19AHomo sapiens-mutation abolishes phosphorylation and alters the subcellular localization from predominantly nuclear to significantly cytoplasmic652918
S19EHomo sapiens-mutant enzyme is localized around the nuclear envelope, but does not penetrate into the nucleoplasm, in vitro DNA-binding affinity is strongly reduced652918
W121AHomo sapiens-mutant enzymes W121A, H54Q, R55A, F60A, Q111A, F133A, and H126Q. Mutants enzymes H54Q, Q111A, F113A, and W121A retain 3-15% of the catalytic efficiency of the wild-type recombinant enzyme. The mutants R55A, F60A and H126Q, each retain less than 1% of the wild-type recombinant catalytic efficiency. The wild-type enzyme and the mutants R55A, F60A, F113A, and H126Q inhibit calcineurin in the presence of cyclosporin A, whereas W121A does not2596
W34AHomo sapiens-cells expressing Pin1 mutant W34A do not inhibit FOXO4 relocalization to the nucleus upon stimulation with hydrogen peroxide691625
W34AHomo sapiens-mutation in WW domain. Mutation diminishes binding to brain-specifc protein BNIP-H694818
R62ARattus norvegicus-overexpression of wild-type isoform CypB attenuates endoplasmic reticulum stress-induced cell death, whereas overexpression of isomerase activity-defective mutant R62A increases Ca2+ leakage from the endoplasmic reticulum and generation of reactive oxygen species and decreases mitochondrial membrane potential resulting in cell death693310
S16ARattus norvegicus-a dominant negative mutant704154
C54SArabidopsis thalianaP34791presence of dithiothreitol, 40% of wild-type activity, presence of H2O2, 123% of wild-type activity678048
additional informationArabidopsis thalianaQ9SCY2construction of DNA T-insertion mutants. PPIase activity in the thylakoid lumen of the mutants lacking either AtFKBP13 or both AtFKBP13 and AtCYP20-2 is 10% and 2%, respectively, of wild-type activity. Residual PPIase activity detected in the double mutant originates from AtCYP20-3. None of the mutants differs from the wild-type plants when grown under normal, cold stress or high light conditions706176
additional informationCampylobacter jejuni-construction of a cj0596 deletion mutant derivative of strain 81-176, isolation of a revertant of this mutant by restoring the gene to its original chromosomal location using streptomycin counterselection. The cj0596 mutant strain demonstrates a slightly decreased growth rate and lower final growth yield, yet it is more motile and more invasive of human intestinal epithelial cells than wild-type, phenotype, overview702908
I42S/F132YEscherichia coli-almost complete loss of peptidylprolyl isomerase activity, retains most of hydrogenase activity and cells show moderate deficiency in nickel uptake under anaerobic conditions680509
additional informationEscherichia coli-the deletion mutant comprising the N-terminal domain only, exists in solution as a mixture of monomeric and dimeric species, and exhibits chaperone activity. The deletion mutant comprising the C-terminal domain only is monomeric, and although it shows peptidylprolyl isomerase activity, it is devoid of chaperone function652932
additional informationEscherichia coli-genetic inactivation of isoforms FkpA, PpiA, PpiD, SurA results in a viable strain with decreased growth rate and increased susceptibility to certain antibodies. Expression of P and type 1 pili is severely diminished in the quadruple mutant as well as in absence of SurA alone662045
additional informationEscherichia coli-the temperature-sensitive mutant FkpA43 confers 10% activity to colicin M at 30°C and no activity at 42°C, displays a 2fold lower PPIase activity than wild type FkpA for Phe-Pro-176-Val and a 5fold lower activity for Leu-Pro-260-Gly than for Phe-Pro-176-Val (measured at 10°C)715653
Y221FEscherichia coli-mutant enzyme shows 15% of the activity of the wild-type enzyme with succinyl-Ala-Phe-Pro-Phe-4-nitroanilide as substrate, less active than wild-type enzyme in refolding of reduced and carboxymethylated RNAse T1, chaperone activity comparable with wild-type, not impaired in association with nascent proteins652525
additional informationHaemaphysalis longicornisB2ZWT4, B2ZWT5silencing of isoform cyclophilin A by RNAi leads to a significant reduction in the body weight of engorged ticks and their failure to lay eggs; silencing of isoform cyclophilin B by RNAi does not lead to detectable phenotypic changes694932
K63AHomo sapiens-mutant lacking isomerase activity. Wild-type inhibits FOXO4-induced expression of p27kip1, while mutant K63A does not691625
additional informationHomo sapiens-depletion of enzyme by siRNA reduces hormone-dependent transcription from both transfected reporters and an endogenous steroid receptor target gene. Depletion of enzyme in MCF-7 cells reduces the endogenous estrogen-dependent recruitment of p300 to the promoters of estrogen receptor-dependent genes. Enzyme overexpression enhances SRC-3 cellular turnover662861
additional informationHomo sapiens-analysis of residues conserved in natural Pin1 sequences and during unigenic evolution and screen for completely conserved residues in functional Pin1 mutants by complementation of Ess1 mutant in Saccharomyces cerevisiae681404
additional informationHomo sapiens-Pin1 overexpression increases the reporter activities in cells transfected with reporters containing the vascular endothelial growth factor VEGF gene promoter or with minimal reporters of activator protein-1 and hypoxia response element. VEGF reporter gene activity is significantly inhibited by either hypoxia-inducible factor-alpha siRNA or AP-1 decoy ODN. Pin1 stimulates VEGF expression by activating HIF-1alpha and AP-1, and is a potential therapeutic target of angiogenesis during cancer development690722
additional informationHomo sapiens-co-expression of cyclophilin B with TRPV6 channel protein in Xenopus laevis oocytes results in significant increase in TRPV6-mediated calcium uptake. Effect is reversed by addition of cyclosporin A693077
additional informationHomo sapiens-both hydrogen peroxide and heat stresses induce phosphorylation of neurofilament protein NF-H in transfected HEK-293 cells and primary cortical cultures. Knockdown of Pin1 by transfected Pin1 short interference RNA and dominant negative-Pin1 rescues the effect of stress-induced NF-H phosphorylation693136
additional informationHomo sapiens-a WW domain mutant of Pin1 can no longer interact with NF-kappaB703021
additional informationHomo sapiens-depletion of Pin1 from HeLa cells causes a cytokinesis defect, overview703024
additional informationHomo sapiens-overexpression of Pin1 reduces wild-type tau stability but increases P301L mutant tau stability704154
additional informationHomo sapiens-introduction of point mutations in the prolyl-peptidyl isomerase motif of CyPA. Downregulation of host CyPA by RNA interference, and mutations in viral NS5B, that confers cyclosporine-resistant binding to CyPA, contribute to the cyclosporine resistance of the replicons harboring these mutations705430
additional informationHomo sapiens-Par14 knockout leads to suppression of cell growth, phenotype, overview705715
additional informationHomo sapiens-repression of Pin1 expression through either homologue Pin1 knockout or small interfering RNA-mediated knockdown compromises its ability to protect Akt from degradation706012
W34A/K63AHomo sapiens-catalytically inactive715524
additional informationLegionella pneumophila-enzyme defective mutant lacks 40-70% of secreted p-nitrophenol phosphorylcholine hydrolase activity. C-terminus of Mip is required for activation/secretion of p-nitrophenol phosphorylcholine hydrolase680130
additional informationLegionella pneumophila-mutants lacking PpiB activity exhibit reduced growth at 17°C690528
additional informationMus musculus-Pin1 knockout mice show reduced neutrophile accumulation in the liver, reduced NF-kappaB activation, and increased nuclear p65 protein expression compared to wild-type mice, phenotypes, overview704931
additional informationNeisseria gonorrhoeae-enzyme deletion mutant, enzyme is not required in log phase of growth. Mutation does not affect the binding of strain to macrophages but decreases intracellular survival in macrophages662909
DELTA208-213Oryctolagus cuniculus-almost no enzymic activity, 400fold less activity in the activation reaction of PP2A phosphatase662459
additional informationRattus norvegicus-enzyme overexpression renders isolated mitochondria far more susceptible to the permeability transition induced by Ca2+ and oxidative stress. Overexpressing cells maintain a lower inner-membrane potential of mitochondria than those of normal cells. Effects are abolished by cyclosporin A. Cyclosporin-D overexpression promotes NO-induced necrosis and inhibits staurosporine-induced apoptosis660983
additional informationRattus norvegicusB0BNL2in isoform Pin1-deficient neuronal cell cultures, H2O2 stress-induced phosphoprotein Tau dephosphorylation at Thr231 is significantly lower than in wild-type neurons680665
additional informationRattus norvegicus-overexpression of wild-type isoform CypB attenuates endoplasmic reticulum stress-induced cell death, whereas overexpression of isomerase activity-defective mutant R62A increases Ca2+ leakage from the endoplasmic reticulum and generation of reactive oxygen species and decreases mitochondrial membrane potential resulting in cell death. siRNA-mediated inhibition of CypB expression renders cells more vulnerable to endoplasmic reticulum stress. CypB interacts with the endoplasmic reticulum stress-related chaperones, Bip and Grp94693310
additional informationRattus norvegicus-overexpression of Pin1 reduces wild-type tau stability but increases P301L mutant tau stability704154
additional informationRattus norvegicus-silencing of Pin1 by siRNA, Pin1 siRNA-transfected neurons show the reduction in perikaryal phosphorylation of NF, siRNA inhibits okadaic acid-induced perikaryal phosphorylation of NF-M/H, immunohistochemic analysis, overview705286
additional informationRattus norvegicusO42123overexpression of mutant FKBP52-FD67DV, but not of wild-type FKBP52, leads to similar midline targeting errors and premature fasciculation705910
D205GSaccharomyces cerevisiae-D205 is required for both peptidylprolyl isomerase activity and protein phosphatase 2A activation; essential for petidyl-prolyl cis/trans isomerase activity and activation of PP2A phosphatase662459
additional informationSalmonella enterica subsp. enterica serovar Typhimurium-disruption of the fkpA gene results in a 47.9fold and 32.1fold decrease in thermotolerance in 5-h and 24-h CS cells, respectively, compared to the parental strain701755
additional informationStreptococcus pneumoniae-enzyme knockout mutant, in mouse pneumonia model no significant difference to wild-type. Deficiency in enzyme does not reduce binding activity of strain to host target proteins but results in enhanced uptake by professional phagocytes662464
additional informationTrypanosoma cruziQ2I5R9enzyme is able to replace the essential homolog Ess1 in Saccharomyces cerevisiae681821
additional informationXenopus laevisO42123overexpression of mutant FKBP52-FD67DV, but not of wild-type FKBP52, leads to similar midline targeting errors and premature fasciculation705910

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
analysisHomo sapiens-high-throughput screening method for isoform FKBP12 binding based on the decrease of a fluorescence signal generated by a small molecule fluorescent FKBP12 ligand bound to the protein and measured in the presence of inhibitor678627
medicineHomo sapiens-cyclophilin B is critical for the efficient replication of the hepatitis C virus genome. enzyme interacts with the viral RNA polymerase NS5B to directly stimulate its RNA binding activity662835
medicineHomo sapiens-enzyme isoform PPIL1 is frequently overexpressed in colon cancer cells. Wild-type PPIL1 shows a growth-promoting effect on NIH-3T3 and HEK-293 cells. Consistently, transfection with its siRNA reduces gene expression and retards growth of colon cancer cells. Enzyme interacts with SNW1/SKI-binding protein and with stathmin679270
medicineHomo sapiens-Pin1 overexpression increases the reporter activities in cells transfected with reporters containing the vascular endothelial growth factor VEGF gene promoter or with minimal reporters of activator protein-1 and hypoxia response element. VEGF reporter gene activity is significantly inhibited by either hypoxia-inducible factor-alpha siRNA or AP-1 decoy ODN. Pin1 stimulates VEGF expression by activating HIF-1alpha and AP-1, and is a potential therapeutic target of angiogenesis during cancer development690722
medicineHomo sapiens-isoform Pin1 is a critical regulator of p27kip1 through inhibition of Forkhead box O, FOXO4. Oxidative stress induces binding of Pin1 to FOXO4 thereby attenuating its monoubiquitination. Pin1 prevents nuclear FOXO4 accumulation and acts on FOXO through stimulation of the activity of the deubiquitinating enzyme HAUSP/USP7691625
medicineHomo sapiens-isoform CypA is necessary for the prolactin-induced activation of Janus-activated kinase 2 and the progression of human breast cancer. Direct correlation between the levels of activity of CypA and the extent of prolactin-induced signaling and gene expression. A CypA-mediated conformational change withi the prolactin r/Janus-activated kinase 2 complex is required for prolactin-induced transduction and function691626
medicineHomo sapiens-Pin1 is a target molecule for treating diabetes mellitus715609
pharmacologyHomo sapiens-Pin1 is a potential therapeutic target in Rel/NF-kappaB-dependent leukemia/lymphomas703021
pharmacologyHomo sapiens-Pin1 is a therapeutic target for reducing aberrant phosphorylation of NF proteins in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis705286
medicineMus musculus-Pin1 inhibitors can be used as a novel type of anticancer drug that acts by blocking cell cycle progression650816
medicineMus musculus-Pin1 is a target molecule for treating diabetes mellitus715609
agricultureSorghum bicolor-use of leaf enzyme activity as a marker for water stress tolerance in sorghum682273
analysisSus scrofa-the enzyme weakly catalyzes some protein processes which are rate-limited by proline isomerization, but probably exhibits no measurable catalysis towards others. This somewhat limits the usefulness of the enzyme as a diagnostic reagent for proline isomeri2517

DISEASETITLE OF PUBLICATIONLINK TO PUBMED
AcidosisCyclosporin A produces distal renal tubular acidosis by blocking peptidyl prolyl cis-trans isomerase activity of cyclophilin. PubMed
Acidosis, Renal TubularCyclosporin A produces distal renal tubular acidosis by blocking peptidyl prolyl cis-trans isomerase activity of cyclophilin. PubMed
Acquired Immunodeficiency SyndromeContribution of Cyclophilin A to determination of simian immunodeficiency virus tropism: a progress update. PubMed
Acquired Immunodeficiency SyndromeExpression of human placental alkaline phosphatase in Escherichia coli. PubMed
Acquired Immunodeficiency SyndromeRegulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. PubMed
Acquired Immunodeficiency SyndromeSynthesis and evaluation of Glypsi(PO(2)R-N)Pro-containing pseudopeptides as novel inhibitors of the human cyclophilin hCyp-18. PubMed
Acquired Immunodeficiency Syndrome[Experimental research of targeting hTERT gene inhibited in hepatocellular carcinoma therapy by RNA interference] PubMed
Acute Coronary SyndromeBromocriptine-induced coronary spasm caused acute coronary syndrome, which triggered its own clinical twin - takotsubo syndrome. PubMed
Acute Coronary SyndromeThe clinical implications of increased cyclophilin A levels in patients with acute coronary syndromes. PubMed
Acute Kidney InjuryLiver proteomics for therapeutic drug discovery: inhibition of the cyclophilin receptor CD147 attenuates sepsis-induced acute renal failure. PubMed
Acute Kidney InjuryREGULATION OF THE MITOCHONDRIAL PERMEABILITY TRANSITION IN KIDNEY PROXIMAL TUBULES AND ITS ALTERATION DURING HYPOXIA/REOXYGENATION. PubMed
AdenocarcinomaA cyclophilin B gene encodes antigenic epitopes recognized by HLA-A24-restricted and tumor-specific CTLs. PubMed
AdenocarcinomaFKBP51 expressed by both normal epithelial cells and adenocarcinoma of colon suppresses proliferation of colorectal adenocarcinoma. PubMed
AdenomaApoptosis, mitosis and cyclophilin-40 expression in regressing peroxisome proliferator-induced adenomas. PubMed
Adenomatous Polyposis ColiActivation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction. PubMed
Alkalosis[Nature of metabolic alkalosis in the postoperative period in patients with pulmonary tuberculosis] PubMed
Alzheimer DiseaseA peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles. PubMed
Alzheimer DiseaseAmyloid-? as a Modulator of Synaptic Plasticity. PubMed
Alzheimer DiseaseCyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. PubMed
Alzheimer DiseaseCyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model. PubMed
Alzheimer DiseaseDecrease of the Immunophilin FKBP52 Accumulation in Human Brains of Alzheimer's Disease and FTDP-17. PubMed
Alzheimer DiseaseFKBP51 and FKBP52 in signaling and disease. PubMed
Alzheimer DiseaseGranular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer's disease pathology and is independent of tau, A? and TDP-43 pathology. PubMed
Alzheimer DiseaseMitochondrial modulation of store-operated Ca(2+) entry in model cells of Alzheimer's disease. PubMed
Alzheimer DiseaseMitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta. PubMed
Alzheimer DiseasePeptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease. PubMed
Alzheimer DiseasePin1 allows for differential Tau dephosphorylation in neuronal cells. PubMed
Alzheimer DiseasePIN1 gene variants in Alzheimer's disease. PubMed
Alzheimer DiseasePossible role of amyloid-beta, adenine nucleotide translocase and cyclophilin-D interaction in mitochondrial dysfunction of Alzheimer's disease. PubMed
Alzheimer DiseaseQuantifying mRNA in postmortem human brain: influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variance. PubMed
Alzheimer DiseaseStructural analysis of the mitotic regulator hPin1 in solution: insights into domain architecture and substrate binding. PubMed
Alzheimer DiseaseThe Caenorhabditis elegans parvulin gene subfamily and their expression under cold or heat stress along with the fkb subfamily. PubMed
Alzheimer DiseaseThe Dynamics of CD147 in Alzheimer's Disease Development and Pathology. PubMed
Alzheimer DiseaseThe role of Cyclophilin D in learning and memory. PubMed
Amyotrophic Lateral SclerosisApoptosis-Inducing Factor and Cyclophilin A Cotranslocate to the Motor Neuronal Nuclei in Amyotrophic Lateral Sclerosis Model Mice. PubMed
Amyotrophic Lateral SclerosisImmunophilins in nervous system degeneration and regeneration. PubMed
Amyotrophic Lateral SclerosisLife span extension and reduced neuronal death after weekly intraventricular cyclosporin injections in the G93A transgenic mouse model of amyotrophic lateral sclerosis. PubMed
Amyotrophic Lateral SclerosisThe mitochondrial calcium regulator cyclophilin D is an essential component of oestrogen-mediated neuroprotection in amyotrophic lateral sclerosis. PubMed
AnaphylaxisAnaphylaxis, killer allergy: Long-term management in the community. PubMed
Anemia[The activities of the renin-angiotensin-aldosterone and sympathetic-adrenal systems during hemodialysis] PubMed
Anemia[Thrombotic thrombocytopenic purpura: report of seven cases] PubMed
Anemia, Sickle CellSalmonella Bacteremia in Kenyan Children. PubMed
Antiphospholipid SyndromeAntiphospholipid syndrome during pegylated interferon alpha-2a therapy for chronic hepatitis C. PubMed
Aortic AneurysmCyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. PubMed
Arrhythmias, Cardiac[From provocation tests to clinical practice: invasive and non-invasive electrophysiology] PubMed
ArthritisChlamydial infection in a family. PubMed
ArthritisHigh binding capacity of cyclophilin B to chondrocyte heparan sulfate proteoglycans and its release from the cell surface by matrix metalloproteinases: possible role as a proinflammatory mediator in arthritis. PubMed
Arthritis, RheumatoidContribution of Cyclophilin A to the Regulation of Inflammatory Processes in Rheumatoid Arthritis. PubMed
Arthritis, RheumatoidCyclophilin A may contribute to the inflammatory processes in rheumatoid arthritis through induction of matrix degrading enzymes and inflammatory cytokines from macrophages. PubMed
Arthritis, RheumatoidCyclophilin A up-regulates MMP-9 expression and adhesion of monocytes/macrophages via CD147 signalling pathway in rheumatoid arthritis. PubMed
Arthritis, RheumatoidCyclophilin A: promising new target in cardiovascular therapy. PubMed
Arthritis, RheumatoidDealing with the family: CD147 interactions with cyclophilins. PubMed
Arthritis, RheumatoidPossible involvement of peptidylprolyl isomerase Pin1 in rheumatoid arthritis. PubMed
Arthritis, RheumatoidPresence of cyclophilin A in synovial fluids of patients with rheumatoid arthritis. PubMed
Arthritis, RheumatoidVascular-derived reactive oxygen species for homeostasis and diseases. PubMed
AsthmaBetelnut chewing causes bronchoconstriction in some asthma patients. PubMed
AsthmaBlocking Cyclophilins in Chronic Phase of Asthma Reduces Leukocyte Persistence and Disease Reactivation. PubMed
AsthmaEffects of allergen and trigger factor avoidance advice in primary care on asthma control: a randomized-controlled trial. PubMed
AsthmaExercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers. PubMed
AsthmaExtracellular cyclophilin levels associate with parameters of asthma in phenotypic clusters. PubMed
AsthmaGastro-oesophageal reflux and nocturnal asthma. PubMed
AsthmaGastro-oesophageal reflux and triggering of bronchial asthma: a negative report. PubMed
AsthmaPatients' perceptions of food-induced asthma. PubMed
AsthmaPostcoital asthma and rhinitis. PubMed
AsthmaPrevalence of bronchial asthma in patients with endoscopically-documented esophagitis. PubMed
AsthmaThe effect of passive smoking on respiratory health in children and adults. PubMed
Asthma[Analysis of IgE reactivities of purified allergens from Candida albicans and Malassezia furfur among patients with atopic dermatitis] PubMed
Asthma[Environmental control for allergic diseases--avoiding and killing effect on housedust-mite by eastern red cedar] PubMed
Asthma[Rhinitis, asthma and sports] PubMed
Asthma[The epidemiology of asthma in Lorraine. A method of Study (author's transl)] PubMed
AtaxiaNerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons. PubMed
Ataxia TelangiectasiaRAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. PubMed
AtherosclerosisA fibre cocktail of fenugreek, guar gum and wheat bran reduces oxidative modification of LDL induced by an atherogenic diet in rats. PubMed
AtherosclerosisA search for cyclophilin-A gene (PPIA) variation and its contribution to the risk of atherosclerosis and myocardial infarction. PubMed
AtherosclerosisCyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice. PubMed
AtherosclerosisCyclophilin-A: a potential screening marker for vascular disease in type-2 diabetes. PubMed
AtherosclerosisProteomic profiling of high glucose primed monocytes identifies cyclophilin A as a potential secretory marker of inflammation in type 2 diabetes. PubMed
Atherosclerosis[Effect of cyclophilin A on monocyte-derived foam cells]. PubMed
Atrial Fibrillation[Clinical characteristics of patients diagnosed of chronic heart failure attended in Primary Care. The CARDIOPRES study] PubMed
Atrial Fibrillation[Conn's syndrome and severe arrhythmias] PubMed
Autoimmune DiseasesAutoantibodies to FK506 binding protein 12 (FKBP12) in autoimmune diseases. PubMed
Autoimmune DiseasesCyclophilin A: promising new target in cardiovascular therapy. PubMed
Autoimmune DiseasesVascular-derived reactive oxygen species for homeostasis and diseases. PubMed
Autoimmune DiseasesX-ray structure of a decameric cyclophilin-cyclosporin crystal complex. PubMed
Autoimmune Diseases[Role of mycoplasma pneumoniae infection in aetiopathogenesis of juvenile idiopatic arthritis] PubMed
AzoospermiaAlterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study. PubMed
BacteriuriaTranscriptional profiles in urine during acute rejection, bacteriuria, CMV infection and stable graft function after renal transplantation. PubMed
Bone DiseasesEndoplasmic reticulum stress or mutation of an EF-hand Ca(2+)-binding domain directs the FKBP65 rotamase to an ERAD-based proteolysis. PubMed
Brain DiseasesHyperactivity of the hypothalamus-pituitary-adrenal axis in lipopolysaccharide-induced neurodevelopmental model of schizophrenia in rats: Effects of antipsychotic drugs. PubMed
Brain InjuriesAcutely increased cyclophilin a expression after brain injury: a role in blood-brain barrier function and tissue preservation. PubMed
Brain InjuriesCyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria. PubMed
Brain InjuriesDevelopmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury. PubMed
Brain InjuriesNeuroprotective effect of Bax-inhibiting peptide on neonatal brain injury. PubMed
Brain InjuriesSearch for novel gene markers of traumatic brain injury by time differential microarray analysis. PubMed
Brain IschemiaComplex contribution of cyclophilin D to Ca2+-induced permeability transition in brain mitochondria, with relation to the bioenergetic state. PubMed
Brain IschemiaCyclophilin C-associated protein and cyclophilin C mRNA are upregulated in penumbral neurons and microglia after focal cerebral ischemia. PubMed
Brain IschemiaCyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. PubMed
Brain IschemiaEvidence that intracellular cyclophilin A and cyclophilin A/CD147 receptor-mediated ERK1/2 signalling can protect neurons against in vitro oxidative and ischemic injury. PubMed
Brain IschemiaPostischemic changes in the immunophilin FKBP12 in the rat brain. PubMed
Brain IschemiaProtection against ischemic brain damage in rats by immunophilin ligand GPI-1046. PubMed
Brain IschemiaThe quantification of ADAMTS expression in an animal model of cerebral ischemia using real-time PCR. PubMed
Brain IschemiaThe specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia. PubMed
Breast NeoplasmsAccumulation of cyclophilin A isoforms in conditioned medium of irradiated breast cancer cells. PubMed
Breast NeoplasmsAllelic loss of cyclophilin 40, an estrogen receptor-associated immunophilin, in breast carcinomas. PubMed
Breast NeoplasmsCyclophilin B as a co-regulator of prolactin-induced gene expression and function in breast cancer cells. PubMed
Breast NeoplasmsDetection of autoantibodies against cyclophilin A and triosephosphate isomerase in sera from breast cancer patients by proteomic analysis. PubMed
Breast NeoplasmsEstradiol-regulated expression of the immunophilins cyclophilin 40 and FKBP52 in MCF-7 breast cancer cells. PubMed
Breast NeoplasmsExpression of cyclophilin B is associated with malignant progression and regulation of genes implicated in the pathogenesis of breast cancer. PubMed
Breast NeoplasmsExpression of the estrogen receptor-associated immunophilins, cyclophilin 40 and FKBP52, in breast cancer. PubMed
Breast NeoplasmsHuman cyclophilin 40 is a heat shock protein that exhibits altered intracellular localization following heat shock. PubMed
Breast NeoplasmsIdentification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women. PubMed
Breast NeoplasmsImmunosuppressant inhibition of P-glycoprotein function is independent of drug-induced suppression of peptide-prolyl isomerase and calcineurin activity. PubMed
Breast NeoplasmsInduction of vascular endothelial growth factor by peptidyl-prolyl isomerase Pin1 in breast cancer cells. PubMed
Breast NeoplasmsModulation of cyclophilin gene expression by N-4-(hydroxyphenyl)retinamide: association with reactive oxygen species generation and apoptosis. PubMed
Breast NeoplasmsMultiparametric duplex real-time nucleic acid sequence-based amplification assay for mRNA profiling. PubMed
Breast NeoplasmsProlyl isomerase cyclophilin a regulation of Janus-activated kinase 2 and the progression of human breast cancer. PubMed
Breast NeoplasmsProteomic analysis of infiltrating ductal carcinoma tissues by coupled 2-D DIGE/MS/MS analysis. PubMed
Breast NeoplasmsThe role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus. PubMed
Breast NeoplasmsThrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells. PubMed
Breast Neoplasms, MaleDetection of protein alterations in male breast cancer using two dimensional gel electrophoresis and mass spectrometry: the involvement of several pathways in tumorigenesis. PubMed
CarcinomaAllelic loss of cyclophilin 40, an estrogen receptor-associated immunophilin, in breast carcinomas. PubMed
CarcinomaAssociation of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma. PubMed
CarcinomaAutoantibodies to tailor-made panels of tumor-associated antigens in breast carcinoma. PubMed
CarcinomaComparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma. PubMed
CarcinomaCyclophilin A-EMMPRIN interaction induces invasion of head and neck squamous cell carcinoma. PubMed
CarcinomaEffects of altered expression and localization of cyclophilin A on differentiation of p19 embryonic carcinoma cells. PubMed
CarcinomaEstradiol-regulated expression of the immunophilins cyclophilin 40 and FKBP52 in MCF-7 breast cancer cells. PubMed
CarcinomaExpression of the estrogen receptor-associated immunophilins, cyclophilin 40 and FKBP52, in breast cancer. PubMed
CarcinomaFKBP-12 exhibits an inhibitory activity on calcium oxalate crystal growth in vitro. PubMed
CarcinomaIdentification of cyclophilin A as a potential prognostic factor for clear-cell renal cell carcinoma by comparative proteomic analysis. PubMed
CarcinomaIncreased expression of peroxiredoxin 6 and cyclophilin A in squamous cell carcinoma of the tongue. PubMed
CarcinomaNovel combinational treatment of cisplatin with cyclophilin A inhibitors in human heptocellular carcinomas. PubMed
CarcinomaNovel progesterone target genes identified by an improved differential display technique suggest that progestin-induced growth inhibition of breast cancer cells coincides with enhancement of differentiation. PubMed
CarcinomaOxidative stress in HPV-driven viral carcinogenesis: redox proteomics analysis of HPV-16 dysplastic and neoplastic tissues. PubMed
CarcinomaRapamycin induces Smad activity in prostate cancer cell lines. PubMed
CarcinomaSignificant correlation of peptidyl-prolyl isomerase overexpression in merkel cell carcinoma with overall survival of patients. PubMed,  PubMed
CarcinomaThe role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus. PubMed
CarcinomaThe rotamase Pin1 is up-regulated, hypophosphorylated and required for cell cycle progression in head and neck squamous cell carcinomas. PubMed
CarcinomaUp-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells. PubMed
Carcinoma, HepatocellularCyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9. PubMed
Carcinoma, HepatocellularEssential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PubMed
Carcinoma, HepatocellularFK506 binding proteins as targets in anticancer therapy. PubMed
Carcinoma, HepatocellularHCV NS5A activates the mammalian target of rapamycin (mTOR) pathway contributing to cell survival via disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR. PubMed
Carcinoma, HepatocellularHepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells. PubMed
Carcinoma, HepatocellularRole of cyclophilin B in tumorigenesis and cisplatin resistance in hepatocellular carcinoma. PubMed
Carcinoma, HepatocellularSubcellular distribution of inorganic pyrophosphatase activity in various normal and neoplastic cell types. PubMed
Carcinoma, HepatocellularUp-regulation of beta-actin, cyclophilin and GAPDH in N1S1 rat hepatoma. PubMed
Carcinoma, Merkel CellSignificant correlation of peptidyl-prolyl isomerase overexpression in merkel cell carcinoma with overall survival of patients. PubMed,  PubMed
Carcinoma, Non-Small-Cell LungProtein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer. PubMed
Carcinoma, Non-Small-Cell LungTranslating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer. PubMed
Carcinoma, Renal CellIdentification of cyclophilin A as a potential prognostic factor for clear-cell renal cell carcinoma by comparative proteomic analysis. PubMed
Carcinoma, Squamous CellAssociation of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma. PubMed
Carcinoma, Squamous CellComparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma. PubMed
Carcinoma, Squamous CellCyclophilin A-EMMPRIN interaction induces invasion of head and neck squamous cell carcinoma. PubMed
Carcinoma, Squamous CellIncreased expression of peroxiredoxin 6 and cyclophilin A in squamous cell carcinoma of the tongue. PubMed
Carcinoma, Squamous CellThe rotamase Pin1 is up-regulated, hypophosphorylated and required for cell cycle progression in head and neck squamous cell carcinomas. PubMed
Cardiac Complexes, Premature[Mechanism of spontaneous occurrence of tachycardia] PubMed
CardiomegalyCyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E-Deficient Mice. PubMed
CardiomyopathiesEMMPRIN and its ligand Cyclophilin A as novel diagnostic markers in inflammatory cardiomyopathy. PubMed
Cardiomyopathies[Clinical characteristics of patients diagnosed of chronic heart failure attended in Primary Care. The CARDIOPRES study] PubMed
Cardiomyopathy, DilatedAbsence of viral nucleic acids in early and late dilated cardiomyopathy. PubMed
Cardiovascular DiseasesThe clinical implications of increased cyclophilin A levels in patients with acute coronary syndromes. PubMed
Cardiovascular Diseases[Lipid peroxidation and the antioxidant system in subjects exposed to the influence of extreme factors] PubMed
Cell Transformation, NeoplasticCyclophilin C-associated protein (CyCAP) knock-out mice spontaneously develop colonic mucosal hyperplasia and exaggerated tumorigenesis after treatment with carcinogen azoxymethane1. PubMed
Cell Transformation, NeoplasticCyclophilin D, a component of the permeability transition-pore, is an apoptosis repressor. PubMed
Cell Transformation, NeoplasticEffects of cyclophilin A on cell proliferation and gene expressions in human vascular smooth muscle cells and endothelial cells. PubMed
Cell Transformation, NeoplasticFKBP38-Bcl-2 interaction: a novel link to chemoresistance. PubMed
Cell Transformation, NeoplasticFKBP51 regulation of AKT/protein kinase B phosphorylation. PubMed
Cell Transformation, NeoplasticInduction of vascular endothelial growth factor by peptidyl-prolyl isomerase Pin1 in breast cancer cells. PubMed
Cell Transformation, NeoplasticRole of cyclophilin a during oncogenesis. PubMed
Cell Transformation, NeoplasticRole of cyclophilin B in tumorigenesis and cisplatin resistance in hepatocellular carcinoma. PubMed
Cell Transformation, NeoplasticThe essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability. PubMed
Cell Transformation, NeoplasticUp-regulation of beta-actin, cyclophilin and GAPDH in N1S1 rat hepatoma. PubMed
Chagas DiseaseTrypanosoma cruzi macrophage infectivity potentiator has a rotamase core and a highly exposed alpha-helix. PubMed
CholangiocarcinomaCyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma. PubMed
CholeraFKBP12 mRNA expression is upregulated by intrinsic CNS neurons regenerating axons into peripheral nerve grafts in the brain. PubMed
CholeraNasal immunization with recombinant Brucella melitensis bp26 and trigger factor with cholera toxin reduces B. melitensis colonization. PubMed
Cluster HeadacheCluster Headache is Associated With the Alcohol Dehydrogenase 4 (ADH4) Gene. PubMed
CoinfectionIdentification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria. PubMed
CoinfectionSingle-polarity recombinant adeno-associated virus 2 vector-mediated transgene expression in vitro and in vivo: mechanism of transduction. PubMed
Colitis, UlcerativeUlcerative colitis precipitated by a verocytotoxin-producing Escherichia coli infection. PubMed
Colonic NeoplasmsFKBP51 expressed by both normal epithelial cells and adenocarcinoma of colon suppresses proliferation of colorectal adenocarcinoma. PubMed
Colonic NeoplasmsHsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus. PubMed
Colonic NeoplasmsOverexpression of peptidyl-prolyl isomerase-like 1 is associated with the growth of colon cancer cells. PubMed
Colonic NeoplasmsThe mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction. PubMed
Colorectal NeoplasmsExpression of FK506 binding protein 65 (FKBP65) is decreased in epithelial ovarian cancer cells compared to benign tumor cells and to ovarian epithelium. PubMed
Colorectal NeoplasmsExtent of over-expression of hepatocyte growth factor receptor in colorectal tumours is dependent on the choice of normaliser. PubMed
Colorectal NeoplasmsModulated T-complex protein 1 ? and peptidyl-prolyl cis-trans isomerase B are two novel indicators for evaluating lymph node metastasis in colorectal cancer: Evidence from proteomics and bioinformatics. PubMed
Common Variable ImmunodeficiencyAdvances in basic and clinical immunology. PubMed
Common Variable ImmunodeficiencyAge-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency. PubMed
Common Variable ImmunodeficiencyDeficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival. PubMed
Common Variable ImmunodeficiencyFunctional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable immunodeficiency. PubMed
Common Variable ImmunodeficiencyRare mutations in TNFRSF13B increase the risk of asthma symptoms in Swedish children. PubMed
Common Variable ImmunodeficiencySelective IgA deficiency. PubMed
Common Variable ImmunodeficiencyTACI mutation with invasive polyclonal CD8+ T-cell lymphoproliferation in a patient with common variable immunodeficiency. PubMed
Common Variable ImmunodeficiencyThe C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency. PubMed
Common Variable ImmunodeficiencyThe C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice. PubMed
Common Variable ImmunodeficiencyTransmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation. PubMed
Common Variable ImmunodeficiencyTransmembrane activator and calcium-modulating cyclophilin ligand interactor mutations in common variable immunodeficiency: clinical and immunologic outcomes in heterozygotes. PubMed
Common Variable ImmunodeficiencyTransmembrane activator and calcium-modulator and cyclophilin ligand interactor mutations in common variable immunodeficiency. PubMed
Coronary Artery Disease[Sudden death and chronic cardiac insufficiency] PubMed
Coronary DiseaseHelicobacter pylori active infection in patients with acute coronary heart disease. PubMed
Cystic FibrosisFK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability. PubMed
Cystic FibrosisFKBP38 peptidylprolyl isomerase promotes the folding of cystic fibrosis transmembrane conductance regulator in the endoplasmic reticulum. PubMed
DeafnessConditional deletion of calcium-modulating cyclophilin ligand causes deafness in mice. PubMed
Dental CariesTrigger factor in Streptococcus mutans is involved in stress tolerance, competence development, and biofilm formation. PubMed
DermatitisLack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis. PubMed
Dermatitis, AtopicAlpha-toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatitis. PubMed
Dermatitis, AtopicCell-penetrating peptides as antifungals towards Malassezia sympodialis. PubMed
Dermatitis, AtopicDysregulation of CD36 upon TLR-2 stimulation in monocytes from patients with atopic dermatitis and the TLR2 R753Q polymorphism. PubMed
Dermatitis, AtopicEffect of staphylococcal enterotoxin B on specific antibody production in children with atopic dermatitis. PubMed
Dermatitis, AtopicFood hypersensitivity and atopic dermatitis. PubMed
Dermatitis, AtopicHigher pH level, corresponding to that on the skin of patients with atopic eczema, stimulates the release of Malassezia sympodialis allergens. PubMed
Dermatitis, AtopicIgE antibodies to Malassezia furfur, M. sympodialis and Pityrosporum orbiculare in patients with atopic dermatitis, seborrheic eczema or pityriasis versicolor, and identification of respective allergens. PubMed
Dermatitis, AtopicIL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema. PubMed
Dermatitis, AtopicIsolation of alpha-toxin-producing Staphylococcus aureus from the skin of highly sensitized adult patients with severe atopic dermatitis. PubMed
Dermatitis, AtopicPositive atopy patch test reactions to Pityrosporum orbiculare in atopic dermatitis patients. PubMed
Dermatitis, AtopicSevere atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB). PubMed
Dermatitis, AtopicStaphylococcal exotoxins exert proinflammatory effects through inhibition of eosinophil apoptosis, increased surface antigen expression (CD11b, CD45, CD54, and CD69), and enhanced cytokine-activated oxidative burst, thereby triggering allergic inflammatory reactions. PubMed
Dermatitis, Atopic[Analysis of IgE reactivities of purified allergens from Candida albicans and Malassezia furfur among patients with atopic dermatitis] PubMed
Dermatitis, Atopic[Malassezia yeasts and their signifcance in dermatology.] PubMed
Diabetes MellitusIncreased frequency of HCV but not HBV infection in type 2 diabetic patients in Turkey. PubMed
Diabetes Mellitus, Type 2Increased frequency of HCV but not HBV infection in type 2 diabetic patients in Turkey. PubMed
EchinococcosisImmunological characterization of Echinococcus granulosus cyclophilin, an allergen reactive with IgE and IgG4 from patients with cystic echinococcosis. PubMed
EclampsiaInfection as a possible trigger factor in the genesis of eclampsia. PubMed
EczemaCell-penetrating peptides as antifungals towards Malassezia sympodialis. PubMed
EczemaEczematous reactions to food in atopic eczema: position paper of the EAACI and GA2LEN. PubMed
Eczema[Environmental control for allergic diseases--avoiding and killing effect on housedust-mite by eastern red cedar] PubMed
EncephalitisImmunophilin expression in the HIV-infected brain. PubMed
Encephalitis, JapaneseInvolvement of cyclophilin B in the replication of Japanese encephalitis virus. PubMed
EncephalomyelitisCyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. PubMed
Encephalomyelitis, Autoimmune, ExperimentalCyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. PubMed
Endometrial NeoplasmsProteomics identification of cyclophilin a as a potential prognostic factor and therapeutic target in endometrial carcinoma. PubMed
Endometrial NeoplasmsProteomics-based approach identified differentially expressed proteins with potential roles in endometrial carcinoma. PubMed
EndometriosisDeficiency of immunophilin FKBP52 promotes endometriosis. PubMed
EndometriosisFKBP52 is regulated by HOXA10 during decidualizaton and in endometriosis. PubMed
EndometriosisThe altered distribution of the steroid hormone receptors and the chaperone immunophilin FKBP52 in a baboon model of endometriosis is associated with progesterone resistance during the window of uterine receptivity. PubMed
Eosinophilia[Churg-Strauss vasculitis and idiopathic hypereosinophyl syndrome: role of molecular biology in the differential diagnosis of hypereosinophyl syndrome] PubMed
Eosinophilic EsophagitisGlucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. PubMed
EpilepsyReversible cerebral vasoconstriction phenomena following indomethacin administration. PubMed
EpilepsyUncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysis. PubMed
Esophageal and Gastric VaricesPortal vein thrombosis after variceal endoscopic sclerotherapy in cirrhotic patients: role of genetic thrombophilia. PubMed
EsophagitisPrevalence of bronchial asthma in patients with endoscopically-documented esophagitis. PubMed
Food HypersensitivityFood hypersensitivity and atopic dermatitis. PubMed
Frontotemporal DementiaShortfalls in the peptidyl-prolyl cis-trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias. PubMed
Gastroenteritis[The development of irritable bowel syndrome after Shigella infection: 3 year follow-up study] PubMed
Gastroesophageal RefluxPrevalence of bronchial asthma in patients with endoscopically-documented esophagitis. PubMed
GlaucomaFK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness. PubMed
Glaucoma, Open-AngleMitochondrial defects and dysfunction in calcium regulation in glaucomatous trabecular meshwork cells. PubMed
GlioblastomaKnockdown of CypA inhibits interleukin-8 (IL-8) and IL-8-mediated proliferation and tumor growth of glioblastoma cells through down-regulated NF-kappaB. PubMed
GliomaA suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx. PubMed
GliomaCyclosporin A and sanglifehrin A enhance chemotherapeutic effect of cisplatin in C6 glioma cells. PubMed
GliomaFK506 binding proteins as targets in anticancer therapy. PubMed
GliomaSuppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells. PubMed
GranulomaIsolation and characterization of granuloma initiation factor. PubMed
GranulomaPulmonary granulomas caused experimentally in mice by a recombinant trigger-factor protein of Propionibacterium acnes. PubMed
Head and Neck NeoplasmsThe rotamase Pin1 is up-regulated, hypophosphorylated and required for cell cycle progression in head and neck squamous cell carcinomas. PubMed
HeadacheAlcohol and migraine: trigger factor, consumption, mechanisms. A review. PubMed
HeadacheChinook winds and migraine headache. PubMed
HeadacheHow do trigger factors acquire the capacity to precipitate headaches? PubMed
HeadacheSymptomatic cluster-like headache triggered by forehead lipoma: a case report and review of the literature. PubMed
HeadacheTriggers of migraine and tension-type headache. PubMed
Headache[Hemicrania: primary headache] PubMed
Headache Disorders[Prophylactic treatment of headache] PubMed
Heart ArrestSelection of reference genes for quantitative real-time PCR in a rat asphyxial cardiac arrest model. PubMed
Heart FailureCa2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. PubMed
Heart FailureCyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. PubMed
Heart FailureFKBP12 activates the cardiac ryanodine receptor ca-release channel and is antagonised by FKBP12.6. PubMed
Heart FailureMitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure. PubMed
Heart FailurePKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure. PubMed
Heart FailureRyanodine receptors, FKBP12, and heart failure. PubMed
HemangiosarcomaExpression of FKBP12 in benign and malignant vascular endothelium: an immunohistochemical study on conventional sections and tissue microarrays. PubMed
Hematologic NeoplasmsThe microtubule-targeting agents, PBOX-6 [pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and paclitaxel, induce nucleocytoplasmic redistribution of the peptidyl-prolyl isomerases, cyclophilin A and pin1, in malignant hematopoietic cells. PubMed
HematuriaChlamydial infection in a family. PubMed
Hepatitis[Experimental research of targeting hTERT gene inhibited in hepatocellular carcinoma therapy by RNA interference] PubMed
Hepatitis ASuppression of Viral RNA Binding and the Assembly of Infectious Hepatitis C Virus Particles in vitro by Cyclophilin Inhibitors. PubMed
Hepatitis AThe effect of ursodeoxycholic acid in children with prolonged hepatitis A virus infection that may be a trigger factor for autoimmune hepatitis. PubMed
Hepatitis BCharacterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization. PubMed
Hepatitis BHepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion: possible link to pathogenesis of HBV infection. PubMed
Hepatitis BProteomic analysis of hepatitis B surface antigen positive transgenic mouse liver and decrease of cyclophilin A. PubMed
Hepatitis B, ChronicHepatitis B-assocciated adult-onset Still's disease presenting with neutrophilic urticaria. PubMed
Hepatitis CA Conserved Tandem Cyclophilin-Binding Site in Hepatitis C Virus Nonstructural Protein 5A Regulates Alisporivir Susceptibility. PubMed
Hepatitis CA major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach. PubMed
Hepatitis CCellular Growth Kinetics Distinguish a Cyclophilin Inhibitor from an HSP90 Inhibitor as a Selective Inhibitor of Hepatitis C Virus. PubMed
Hepatitis CChemical genetics approach to hepatitis C virus replication: cyclophilin as a target for anti-hepatitis C virus strategy. PubMed
Hepatitis CCombinations of cyclophilin inhibitor NIM811 with hepatitis C Virus NS3-4A Protease or NS5B polymerase inhibitors enhance antiviral activity and suppress the emergence of resistance. PubMed
Hepatitis CComparative Study of the Genetic Barriers and Pathways towards Resistance of Selective Inhibitors of Hepatitis C Virus Replication. PubMed
Hepatitis CCorrection: essential role of cyclophilin a for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PubMed
Hepatitis CCyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner. PubMed
Hepatitis CCyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro. PubMed
Hepatitis CCyclophilin A-independent recruitment of NS5A and NS5B into hepatitis C virus replication complexes. PubMed
Hepatitis CCyclophilin B escorts the hepatitis C virus RNA polymerase: a viral achilles heel? PubMed
Hepatitis CCyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. PubMed
Hepatitis CCyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase. PubMed
Hepatitis CCyclophilin inhibitors in hepatitis C viral infection. PubMed
Hepatitis CCyclophilin involvement in the replication of hepatitis C virus and other viruses. PubMed
Hepatitis CCyclophillin A (CyPA) is required for efficient HCMV DNA replication and reactivation. PubMed
Hepatitis CCyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B. PubMed
Hepatitis CCyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A. PubMed
Hepatitis CDEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PubMed
Hepatitis CDebio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. PubMed
Hepatitis CDifferent mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro. PubMed
Hepatitis CDomain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A. PubMed
Hepatitis CEssential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PubMed
Hepatitis CEvaluation of a cyclophilin inhibitor in hepatitis C virus-infected chimeric mice in vivo. PubMed
Hepatitis CHepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells. PubMed
Hepatitis CHepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B. PubMed
Hepatitis CIdentification of cellular and viral factors related to anti-hepatitis C virus activity of cyclophilin inhibitor. PubMed
Hepatitis CIncreased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders. PubMed
Hepatitis CInhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion. PubMed
Hepatitis CMechanism of resistance of hepatitis C virus replicons to structurally distinct cyclophilin inhibitors. PubMed
Hepatitis CMultiple cyclophilins involved in different cellular pathways mediate HCV replication. PubMed
Hepatitis CMultiple Mutations in Hepatitis C Virus NS5A Domain II Are Required To Confer a Significant Level of Resistance to Alisporivir. PubMed
Hepatitis CNIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha interferon. PubMed
Hepatitis CPeptidyl-prolyl isomerase pin1 is a cellular factor required for hepatitis C virus propagation. PubMed
Hepatitis CSuppression of Viral RNA Binding and the Assembly of Infectious Hepatitis C Virus Particles in vitro by Cyclophilin Inhibitors. PubMed
Hepatitis CThe cyclophilin inhibitor alisporivir prevents hepatitis C virus- mediated mitochondrial dysfunction. PubMed
Hepatitis CThe cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naĂ¯ve hepatitis C patients. PubMed
Hepatitis CThe cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus. PubMed
Hepatitis CThe cyclophilin inhibitor SCY-635 disrupts hepatitis C virus NS5A-cyclophilin A complexes. PubMed
Hepatitis CThe isomerase active site of cyclophilin a is critical for HCV replication. PubMed
Hepatitis CThe use of AlphaLISA technology to detect interaction between hepatitis C virus-encoded NS5A and cyclophilin A. PubMed
Hepatitis CTreating hepatitis C: can you teach old dogs new tricks? PubMed
Hepatitis CTreatment of chronic hepatitis C. PubMed
Hepatitis C, ChronicAn evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C. PubMed
Hepatitis C, ChronicHepatitis C therapy: other players in the game. PubMed
Hepatitis C, ChronicThe cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naĂ¯ve hepatitis C patients. PubMed
Hepatitis, AutoimmuneThe effect of ursodeoxycholic acid in children with prolonged hepatitis A virus infection that may be a trigger factor for autoimmune hepatitis. PubMed
HIV InfectionsBasigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. PubMed
HIV InfectionsImmunophilin expression in the HIV-infected brain. PubMed
HIV InfectionsIncreased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders. PubMed
Hodgkin DiseaseTargeting B-lymphocyte stimulator/B-cell activating factor and a proliferation-inducing ligand in hematologic malignancies. PubMed
HyperinsulinismThe housekeeping genes GAPDH and cyclophilin are regulated by metabolic state in the liver of dairy cows. PubMed
Hyperparathyroidism, SecondaryPin1 regulates parathyroid hormone mRNA stability. PubMed
Hyperparathyroidism, SecondaryThe peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism. PubMed
HypersensitivityActivation of Ca2+ signaling in neutrophils by the mast cell-released immunophilin FKBP12. PubMed
HypersensitivityAllergy to pumpkin with cyclophilin as the relevant allergen. PubMed
HypersensitivityCalcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae. PubMed
HypersensitivityCloning and expression of the cyclophilin Bet v 7, and analysis of immunological cross-reactivity among the cyclophilin A family. PubMed
HypersensitivityPulmonary granulomas caused experimentally in mice by a recombinant trigger-factor protein of Propionibacterium acnes. PubMed
HypersensitivitySoluble CD14: role in atopic disease and recurrent infections, including otitis media. PubMed
Hypersensitivity, ImmediateActivation of Ca2+ signaling in neutrophils by the mast cell-released immunophilin FKBP12. PubMed
HypertensionAssociation of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. PubMed
HypertensionCyclosporin A inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolae. PubMed
HypertensionInfluence of pressure overload and ACE inhibitor therapy on constitutive protein mRNA expression in the spontaneously hypertensive rat. PubMed
HypertensionMolecular cloning of a complementary DNA to rat cyclophilin-like protein mRNA. PubMed
HypertensionRemoval of FKBP12/12.6 from endothelial ryanodine receptors leads to an intracellular calcium leak and endothelial dysfunction. PubMed
HypertensionTacrolimus-induced hypertension: what's endothelial and hematopoietic FKBP12 got to do with it? PubMed
Hypertension, PulmonaryDetection of Chlamydia pneumoniae in unexplained pulmonary hypertension. PubMed
HyperventilationChanges in visual-evoked potential habituation induced by hyperventilation in migraine. PubMed
HypoglycemiaHypoglycemia as a trigger for the syndrome of acute bilateral basal ganglia lesions in uremia. PubMed
HypospadiasEssential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. PubMed
HypospadiasFkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis. PubMed
HypospadiasStudies of a co-chaperone of the androgen receptor, FKBP52, as candidate for hypospadias. PubMed
Hypoxia-Ischemia, BrainCyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia. PubMed
IgA DeficiencySelective IgA deficiency. PubMed
Immune System Diseases1-(2,6-Dibenzyloxybenzoyl)-3-(9H-fluoren-9-yl)-urea: A novel cyclophilin A allosteric activator. PubMed
Immunologic Deficiency SyndromesTransmembrane activator and calcium-modulator and cyclophilin ligand interactor mutations in common variable immunodeficiency. PubMed
Infarction, Middle Cerebral ArteryChanges in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain. PubMed
Infection1-(2,6-Dibenzyloxybenzoyl)-3-(9H-fluoren-9-yl)-urea: A novel cyclophilin A allosteric activator. PubMed
InfectionA Critical Role of Cyclophilin A and its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the HCV Replication Complex. PubMed
InfectionA Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection. PubMed
InfectionA Magnaporthe grisea cyclophilin acts as a virulence determinant during plant infection. PubMed
InfectionA novel FK-506 binding like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei. PubMed
InfectionAbsence of viral nucleic acids in early and late dilated cardiomyopathy. PubMed
InfectionAcetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. PubMed
InfectionAlisporivir, a cyclosporin derivative that selectively inhibits cyclophilin, for the treatment of HCV infection. PubMed
InfectionAnalysis of human cell heterokaryons demonstrates that target cell restriction of cyclosporine-resistant human immunodeficiency virus type 1 mutants is genetically dominant. PubMed
InfectionAntibodies are generated during infection to Coxiella burnetii macrophage infectivity potentiator protein (Cb-Mip). PubMed
InfectionBiochemical and functional analyses of the Mip protein: influence of the N-terminal half and of peptidylprolyl isomerase activity on the virulence of Legionella pneumophila. PubMed
InfectionBone marrow suppression and severe anaemia associated with persistent Plasmodium falciparum infection in African children with microscopically undetectable parasitaemia. PubMed
InfectionCD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A. PubMed
InfectionCD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells. PubMed
InfectionCellular restriction targeting viral capsids perturbs human immunodeficiency virus type 1 infection of nondividing cells. PubMed
InfectionChannel catfish, Ictalurus punctatus, cyclophilin A and B cDNA characterization and expression analysis. PubMed
InfectionCharacterization of the behavior of functional viral genomes during the early steps of human immunodeficiency virus type 1 infection. PubMed
InfectionChicken cyclophilin A is an inhibitory factor to influenza virus replication. PubMed
InfectionChlamydia trachomatis Mip-like protein has peptidyl-prolyl cis/trans isomerase activity that is inhibited by FK506 and rapamycin and is implicated in initiation of chlamydial infection. PubMed
InfectionChlamydial serology: comparative diagnostic value of immunoblotting, microimmunofluorescence test, and immunoassays using different recombinant proteins as antigens. PubMed
InfectionChronic infections and autoimmunity. PubMed
InfectionCommon infections and the risk of stroke. PubMed
InfectionCrystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid. PubMed
InfectionCrystal structure of Mip, a prolylisomerase from Legionella pneumophila. PubMed
InfectionCyclophilin A and viral infections. PubMed
InfectionCyclophilin A inhibits rotavirus replication by facilitating host IFN-I production. PubMed
InfectionCyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro. PubMed
InfectionCyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D. PubMed
InfectionCyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection. PubMed
InfectionCyclophilin A-dependent restriction of human immunodeficiency virus type 1 capsid mutants for infection of nondividing cells. PubMed
InfectionCyclophilin and viruses: cyclophilin as a cofactor for viral infection and possible anti-viral target. PubMed
InfectionCyclophilin inhibitors for the treatment of HCV infection. PubMed
InfectionCyclophilin inhibitors in hepatitis C viral infection. PubMed
InfectionCyclophilins Facilitate Dissociation of the Human Papillomavirus Type 16 Capsid Protein L1 from the L2/DNA Complex following Virus Entry. PubMed
InfectionCyclosporin A inhibits the replication of diverse coronaviruses. PubMed
InfectionCyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A. PubMed
InfectionCYP1, a hypovirus-regulated cyclophilin, is required for virulence in the chestnut blight fungus. PubMed
InfectionEffects of gag mutations on human immunodeficiency virus type 1 particle assembly, processing, and cyclophilin A incorporation. PubMed
InfectionEscape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication. PubMed
InfectionEstablishment of a registry and incidence of IDDM in Avellaneda, Argentina. PubMed
InfectionEukaryotic cyclophilin as a molecular switch for effector activation. PubMed
InfectionEvaluation of a rapid test for histidine rich protein 2 for diagnosis of Plasmodium falciparum infection in Cameroonian children. PubMed
InfectionFunctional analysis of Leishmania major cyclophilin. PubMed
InfectionFunctional analysis of the Listeria monocytogenes secretion chaperone PrsA2 and its multiple contributions to bacterial virulence. PubMed
InfectionG2 cell cycle arrest and cyclophilin a in lentiviral gene transfer. PubMed
InfectionGuillain-BarrĂ© syndrome after varicella-zoster infection. Report of two cases. PubMed
InfectionHCV and diabetes mellitus: evidence for a negative association. PubMed
InfectionHelicobacter pylori active infection in patients with acute coronary heart disease. PubMed
InfectionHelicobacter pylori infection in anterior uveitis. PubMed
InfectionHenoch-Schönlein purpura: recurrence and chronicity. PubMed
InfectionHepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion: possible link to pathogenesis of HBV infection. PubMed
InfectionHepatitis B-assocciated adult-onset Still's disease presenting with neutrophilic urticaria. PubMed
InfectionHepatocytes that express variants of cyclophilin a are resistant to HCV infection and replication. PubMed
InfectionHome exposure to Arabian incense (bakhour) and asthma symptoms in children: a community survey in two regions in Oman. PubMed
InfectionHuman Immunodeficiency Virus Type 1 (HIV-1) Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection. PubMed
InfectionIdentification of Legionella spp. by 19 European reference laboratories: results of the European Working Group for Legionella Infections External Quality Assessment Scheme using DNA sequencing of the macrophage infectivity potentiator gene and dedicated online tools. PubMed
InfectionImmunization of female BALB/c mice with Neospora cyclophilin and/or NcSRS2 elicits specific antibody response and prevents against challenge infection by Neospora caninum. PubMed
InfectionImplication of TRIM alpha and TRIMCyp in interferon-induced anti-retroviral restriction activities. PubMed
InfectionIncidence, risk factors, and outcome of herpes zoster in systemic lupus erythematosus. PubMed
InfectionIncreased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders. PubMed
InfectionIncreased frequency of HCV but not HBV infection in type 2 diabetic patients in Turkey. PubMed
InfectionIndependent genesis of chimeric TRIM5-cyclophilin proteins in two primate species. PubMed
InfectionInfection as a possible trigger factor in the genesis of eclampsia. PubMed
InfectionInfection-associated cervical artery dissection. Three cases. PubMed
InfectionInflammation and infections as risk factors for ischemic stroke. PubMed
InfectionInhibition of cyclophilin function in HIV-I infection by cyclosporin A. PubMed
InfectionInhibition of HIV-1 infection by a CCR5-binding cyclophilin from Toxoplasma gondii. PubMed
InfectionInterstitial lung fibrosis and rheumatic disorders in patients with hepatitis C virus infection. PubMed
InfectionLegionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages. PubMed
InfectionLegionella pneumophila Mip, a surface-exposed peptidylproline cis-trans-isomerase, promotes the presence of phospholipase C-like activity in culture supernatants. PubMed
InfectionLentiviral vector gene transfer is limited by the proteasome at postentry steps in various types of stem cells. PubMed
InfectionMalaria diagnosis: false negative parasight-F tests in falciparum malaria patients in Nigeria. PubMed
InfectionMechanism of resistance of hepatitis C virus replicons to structurally distinct cyclophilin inhibitors. PubMed
InfectionMetal-dependent nucleotide binding to the Escherichia coli rotamase SlyD. PubMed
InfectionMicroscopic polyangiitis following recurrent Staphylococcus aureus bacteremia and infectious endocarditis. PubMed
InfectionMolecular analysis of two novel Neisseria gonorrhoeae virulent components: the macrophage infectivity potentiator and the outer membrane protein A. PubMed
InfectionMortality among children in rural areas of the People's Democratic Republic of Yemen. PubMed
InfectionMurine cytomegalovirus inhibits interferon gamma-induced antigen presentation to CD4 T cells by macrophages via regulation of expression of major histocompatibility complex class II-associated genes. PubMed
InfectionNasal immunization with recombinant Brucella melitensis bp26 and trigger factor with cholera toxin reduces B. melitensis colonization. PubMed
InfectionNef enhances HIV-1 infectivity via association with the virus assembly complex. PubMed
InfectionNg-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages. PubMed
InfectionNovel activities of cyclophilin A and cyclosporin A during HIV-1 infection of primary lymphocytes and macrophages. PubMed
InfectionNovel antigens of Helicobacter pylori correspond to ulcer-related antibody pattern of sera from infected patients. PubMed
InfectionOligopeptide cyclophilin inhibitors: a reassessment. PubMed
InfectionOverexpression of a cotton cyclophilin gene (GhCyp1) in transgenic tobacco plants confers dual tolerance to salt stress and Pseudomonas syringae pv. tabaci infection. PubMed
InfectionParasitic infection and autoimmunity. PubMed
InfectionPeptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. PubMed
InfectionPolymorphisms in the regulatory region of the Cyclophilin A gene influence the susceptibility for HIV-1 infection. PubMed
InfectionPotent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components. PubMed
InfectionProteomic comparison of Mycobacterium avium subspecies paratuberculosis grown in vitro and isolated from clinical cases of ovine paratuberculosis. PubMed
InfectionRapid-onset asthma attack: a prospective cohort study about characteristics and response to emergency department treatment. PubMed
InfectionRedistribution of cyclophilin A to viral factories during vaccinia virus infection and its incorporation into mature particles. PubMed
InfectionReliability of rapid diagnostic tests in diagnosing pregnancy-associated malaria in north-eastern Tanzania. PubMed
InfectionRequirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1. PubMed
InfectionSalmonella Bacteremia in Kenyan Children. PubMed
InfectionSecretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection. PubMed
InfectionSelection for loss of Ref1 activity in human cells releases human immunodeficiency virus type 1 from cyclophilin A dependence during infection. PubMed
InfectionSerum and mucosal cytokine profiles in patients with active Helicobacter pylori and ischemic heart disease: is there a relationship? PubMed
InfectionShigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. PubMed
InfectionSoluble CD14: role in atopic disease and recurrent infections, including otitis media. PubMed
InfectionStructure-based identification of small molecule compounds targeting cell cyclophilin A with anti-HIV-1 activity. PubMed
InfectionSuppression of Viral RNA Binding and the Assembly of Infectious Hepatitis C Virus Particles in vitro by Cyclophilin Inhibitors. PubMed
InfectionSynthesis and evaluation of Glypsi(PO(2)R-N)Pro-containing pseudopeptides as novel inhibitors of the human cyclophilin hCyp-18. PubMed
InfectionThe ability of multimerized cyclophilin A to restrict retrovirus infection. PubMed
InfectionThe control of viral infection by tripartite motif proteins and cyclophilin A. PubMed
InfectionThe cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection. PubMed
InfectionThe effect of ursodeoxycholic acid in children with prolonged hepatitis A virus infection that may be a trigger factor for autoimmune hepatitis. PubMed
InfectionThe PPIase active site of Legionella pneumophila Mip protein is involved in the infection of eukaryotic host cells. PubMed
InfectionThe requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid. PubMed
InfectionThe Rift Valley Fever virus protein NSm and putative cellular protein interactions. PubMed
InfectionThe role of viruses in the pathogenesis of hypersensitivity pneumonitis. PubMed
InfectionThe streptococcal lipoprotein rotamase A (SlrA) is a functional peptidyl-prolyl isomerase involved in pneumococcal colonization. PubMed
InfectionToxoplasma gondii cyclophilin 18 regulates the proliferation and migration of murine macrophages and spleen cells. PubMed
InfectionTranscription and Expression of Plasmodium falciparum Histidine-Rich Proteins in Different Stages and Strains: Implications for Rapid Diagnostic Tests. PubMed
InfectionTranscriptional profiles in urine during acute rejection, bacteriuria, CMV infection and stable graft function after renal transplantation. PubMed
InfectionTranscriptome analysis of the entomopathogenic fungus Beauveria bassiana grown on cuticular extracts of the coffee berry borer (Hypothenemus hampei). PubMed
InfectionTrigger factor of Streptococcus suis is involved in stress tolerance and virulence. PubMed
InfectionUlcerative colitis precipitated by a verocytotoxin-producing Escherichia coli infection. PubMed
Infection[Cloning and expressing of cyclophilin B gene from Schistosoma japonnicum and the analysis of immunoprotective effect] PubMed
Infection[Diagnosis and importance of the opportunistic herpes-virus infection in etiology and pathogenesis of different eye diseases] PubMed
Infection[Guillain-BarrĂ© syndrome as a rare cause of acute respiratory insufficiency] PubMed
Infection[Host genetic factors associated with susceptibility to HIV infection and progression of infection] PubMed
Infection[Macrophage activation syndrome in children with rheumatic disorders: a retrospective study on 6 patients] PubMed
Infection[Myasthenia gravis: diagnosis and treatment] PubMed
Infection[ParaSight F in the diagnosis of Plasmodium falciparum malaria] PubMed
Infection[Prolongation of rejection of porcine skin using iodine tincture] PubMed
Infection[Treatment of childhood asthma] PubMed
InfertilityClomiphene citrate as a possible cause of a psychotic reaction during infertility treatment. PubMed
InfertilityDeficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity. PubMed
InfertilityFKBP52 is regulated by HOXA10 during decidualizaton and in endometriosis. PubMed
Infertility, FemaleProteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus. PubMed
Infertility, MaleAlterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study. PubMed
Influenza, HumanChicken cyclophilin A is an inhibitory factor to influenza virus replication. PubMed
Influenza, HumanCyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication. PubMed
Influenza, HumanCyclophilin A Restricts Influenza A Virus Replication through Degradation of the M1 Protein. PubMed
Influenza, HumanCyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the viral ribonucleoprotein complex. PubMed
Influenza, HumanCyclophillin A (CyPA) is required for efficient HCMV DNA replication and reactivation. PubMed
Influenza, HumanCyclosporin A inhibits the influenza virus replication through cyclophilin A-dependent and -independent pathways. PubMed
Intestinal VolvulusA divergent multi-domain cyclophilin is highly conserved between parasitic and free-living nematode species and is important in larval muscle development. PubMed
Intestinal VolvulusA novel cyclophilin from parasitic and free-living nematodes with a unique substrate- and drug-binding domain. PubMed
LegionellosisDetection of legionellae in hospital water samples by quantitative real-time LightCycler PCR. PubMed
Legionnaires' DiseasePipecolic Acid Derivatives As Small-Molecule Inhibitors of the Legionella MIP Protein. PubMed
Legionnaires' DiseaseSolution structure of the Legionella pneumophila Mip-rapamycin complex. PubMed
Leprosy, LepromatousAutoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease. PubMed
LeukemiaA cyclophilin B gene encodes antigenic epitopes recognized by HLA-A24-restricted and tumor-specific CTLs. PubMed
LeukemiaHigh frequency of alternative splicing of human genes participating in the HIV-1 life cycle: a model using TSG101, betaTrCP, PPIA, INI1, NAF1, and PML. PubMed
LeukemiaIdentification of several cyclosporine binding proteins in lymphoid and non-lymphoid cells in vivo. PubMed
LeukemiaImmediate early gene X-1 interacts with proteins that modulate apoptosis. PubMed
LeukemiaLocal effects of mifepristone on the nonhuman primate endometrium. PubMed
LeukemiaRapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells. PubMed
Leukemia, Lymphocytic, Chronic, B-CellFK506 binding proteins as targets in anticancer therapy. PubMed
Leukemia, Lymphocytic, Chronic, B-CellTargeting B-lymphocyte stimulator/B-cell activating factor and a proliferation-inducing ligand in hematologic malignancies. PubMed
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveThe microtubule-targeting agents, PBOX-6 [pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and paclitaxel, induce nucleocytoplasmic redistribution of the peptidyl-prolyl isomerases, cyclophilin A and pin1, in malignant hematopoietic cells. PubMed
Leukemia, T-CellIdentification of several cyclosporine binding proteins in lymphoid and non-lymphoid cells in vivo. PubMed
Leukemia, T-CellPeptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaB. PubMed
Liver AbscessDifferential gene expression in Entamoeba histolytica isolated from amoebic liver abscess. PubMed
Liver AbscessInhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506. PubMed
Liver Abscess, AmebicCloning and characterization of Entamoeba histolytica antigens recognized by human secretory IgA antibodies. PubMed
Liver CirrhosisN-methyl-4-isoleucine cyclosporine attenuates CCl? -induced liver fibrosis in rats by interacting with cyclophilin B and D. PubMed
Liver DiseasesPathogenesis and pathology of liver disease associated with alpha 1-antitrypsin deficiency. PubMed
Liver NeoplasmsAndrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore. PubMed
Lung DiseasesDealing with the family: CD147 interactions with cyclophilins. PubMed
Lung InjuryDevelopmental regulation and coordinate reexpression of FKBP65 with extracellular matrix proteins after lung injury suggest a specialized function for this endoplasmic reticulum immunophilin. PubMed
Lung InjuryEpithelial Cell Death is an Important Contributor to Oxidant-Mediated Acute Lung Injury. PubMed
Lung NeoplasmsA complex pattern of translational initiation and phosphorylation in L-myc proteins. PubMed
Lung NeoplasmsCyclophilin A is upregulated in small cell lung cancer and activates ERK1/2 signal. PubMed
Lung NeoplasmsDiscovery of novel cyclophilin a ligands using an h/d exchange- and mass spectrometry-based strategy. PubMed
Lung NeoplasmsGlucocorticoid receptor activates poised FKBP51 locus through long-distance interactions. PubMed
Lung NeoplasmsInhibition of Plk1 and Pin1 by 5'-nitro-indirubinoxime suppresses human lung cancer cells. PubMed
Lung NeoplasmsPhase 1 clinical study of cyclophilin B peptide vaccine for patients with lung cancer. PubMed
Lung NeoplasmsProtein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer. PubMed
Lung NeoplasmsStable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo. PubMed
Lung NeoplasmsThroughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection. PubMed
Lung NeoplasmsTranslating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer. PubMed
Lung Neoplasms[Clinical significance of oncogene product expression in human lung cancer] PubMed
Lupus Erythematosus, CutaneousClinical and laboratory characteristics of Finnish lupus erythematosus patients with cutaneous manifestations. PubMed
Lupus Erythematosus, DiscoidClinical and laboratory characteristics of Finnish lupus erythematosus patients with cutaneous manifestations. PubMed
Lupus Erythematosus, SystemicAutoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease. PubMed
Lupus Erythematosus, SystemicIncreased BCMA expression in lupus marks activated B cells, and BCMA receptor engagement enhances the response to TLR9 stimulation. PubMed
Lupus Erythematosus, SystemicPresence of anti-FKBP12 autoantibodies in patients with liver allografts: its association with allograft rejection. PubMed
Lupus Erythematosus, SystemicPresence of autoantibodies to peptidyl-prolyl cis-trans isomerase (cyclosporin A-binding protein) in systemic lupus erythematosus. PubMed
Lyme DiseaseAutoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease. PubMed
LymphomaThe heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein. PubMed
Lymphoma, Large-Cell, AnaplasticThe heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein. PubMed
Lymphoma, Non-HodgkinTargeting B-lymphocyte stimulator/B-cell activating factor and a proliferation-inducing ligand in hematologic malignancies. PubMed
Lymphoma, T-CellCloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis. PubMed
MalariaA comparison of thick smears, QBC malaria, PCR and PATH falciparum malaria test trip in Plasmodium falciparum diagnosis. PubMed
MalariaBone marrow suppression and severe anaemia associated with persistent Plasmodium falciparum infection in African children with microscopically undetectable parasitaemia. PubMed
MalariaComparison of a rapid field immunochromatographic test to expert microscopy for the detection of Plasmodium falciparum asexual parasitemia in Thailand. PubMed
MalariaDetailed characterization of a cyclophilin from the human malaria parasite Plasmodium falciparum. PubMed
MalariaDetection of histidine rich protein 2 and panmalarial ICT Malaria Pf/Pv test antigens after chloroquine treatment of uncomplicated falciparum malaria does not reliably predict treatment outcome in eastern Indonesia. PubMed
MalariaEvaluation of a rapid antigen capture assay for the diagnosis of falciparum malaria. PubMed
MalariaEvaluation of different methods for diagnosis of P. falciparum malaria. PubMed
MalariaEvaluation of two tests based on the detection of histidine rich protein 2 for the diagnosis of imported Plasmodium falciparum malaria. PubMed
MalariaMalaria diagnosis: false negative parasight-F tests in falciparum malaria patients in Nigeria. PubMed
MalariaMolecular and biochemical characterization of a Plasmodium falciparum cyclophilin containing a cleavable signal sequence. PubMed
MalariaParacheck-Pf accuracy and recently treated Plasmodium falciparum infections: is there a risk of over-diagnosis? PubMed
MalariaSalmonella Bacteremia in Kenyan Children. PubMed
MalariaTargeting the hemozoin synthesis pathway for new antimalarial drug discovery: technologies for in vitro beta-hematin formation assay. PubMed
MalariaTrial of the ParaSight-F test for malaria diagnosis in the primary health care system, Zimbabwe. PubMed
Malaria, CerebralVariations in the C-terminal repeats of the knob-associated histidine-rich protein of Plasmodium falciparum. PubMed
Malaria, FalciparumEvaluation of two tests based on the detection of histidine rich protein 2 for the diagnosis of imported Plasmodium falciparum malaria. PubMed
Malaria, VivaxIdentification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria. PubMed
MalnutritionEczematous reactions to food in atopic eczema: position paper of the EAACI and GA2LEN. PubMed
MalnutritionSalmonella Bacteremia in Kenyan Children. PubMed
MalnutritionThe housekeeping genes GAPDH and cyclophilin are regulated by metabolic state in the liver of dairy cows. PubMed
MelanomaCharacterization of human melanoma cell lines and melanocytes by proteome analysis. PubMed
MelanomaComparative proteomic analysis of matched primary and metastatic melanoma cell lines. PubMed
MelanomaFK506 binding proteins as targets in anticancer therapy. PubMed
MelanomaRapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells. PubMed
MelanomaRole of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells. PubMed
MelanomaThe emerging role of large immunophilin FK506 binding protein 51 in cancer. PubMed
Memory DisordersNovel effects on memory observed following unilateral intracranial administration of okadaic acid, cyclosporin A, FK506 and [MeVal4]CyA. PubMed
MetrorrhagiaQuantitative analysis of NIM811, a cyclophilin inhibitor, in human dried blood spots using liquid chromatography-tandem mass spectrometry. PubMed
Migraine DisordersAlcohol and migraine: trigger factor, consumption, mechanisms. A review. PubMed
Migraine DisordersAlcohol Dehydrogenase 2 Genotype and Risk for Migraine. PubMed
Migraine DisordersChanges in visual-evoked potential habituation induced by hyperventilation in migraine. PubMed
Migraine DisordersChildhood and adolescent migraine: A neuropsychiatric disorder? PubMed
Migraine DisordersGeomagnetic activity, humidity, temperature and headache: is there any correlation? PubMed
Migraine DisordersIs stress a trigger factor for migraine? PubMed
Migraine DisordersMigraine and weather: A prospective diary-based analysis. PubMed
Migraine DisordersReversible cerebral vasoconstriction phenomena following indomethacin administration. PubMed
Migraine DisordersTrigger factors in migraine patients. PubMed
Migraine DisordersWeather sensitivity in migraineurs. PubMed
Migraine Disorders[Primary cephaleas. A revision of its diagnosis and therapeutic approach] PubMed
Migraine with AuraReversible cerebral vasoconstriction phenomena following indomethacin administration. PubMed
Motor Neuron DiseaseExpression of FKBP12 and ryanodine receptors (RyRs) in the spinal cord of MND patients. PubMed
Motor Neuron DiseaseFKBP12 immunoreactivity in the human spinal cord of motor neuron disease patients. PubMed
Mouth NeoplasmsDifferential gene expression in neoplastic and human papillomavirus-immortalized oral keratinocytes. PubMed
Multiple MyelomaTargeting B-lymphocyte stimulator/B-cell activating factor and a proliferation-inducing ligand in hematologic malignancies. PubMed
Multiple SclerosisCyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. PubMed
Multiple SclerosisThe role of Cyclophilin D in learning and memory. PubMed
Muscular DystrophiesDebio-025 is more effective than prednisone in reducing muscular pathology in mdx mice. PubMed
Muscular DystrophiesGenetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice. PubMed
Muscular DystrophiesGenetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. PubMed
Muscular DystrophiesGenetic heterogeneity of left-ventricular noncompaction cardiomyopathy. PubMed
Muscular DystrophiesMitochondria in muscle cell death. PubMed
Muscular DystrophiesThe cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1(-/-) myopathic mice. PubMed
Muscular Dystrophy, DuchenneGenetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. PubMed
Muscular Dystrophy, DuchenneInvestigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy. PubMed
Muscular Dystrophy, Emery-DreifussGenetic heterogeneity of left-ventricular noncompaction cardiomyopathy. PubMed
Myocardial InfarctionA search for cyclophilin-A gene (PPIA) variation and its contribution to the risk of atherosclerosis and myocardial infarction. PubMed
Myocardial InfarctionCyclophilin D: knocking on death's door. PubMed
Myocardial IschemiaThe cardioprotective effect of necrostatin requires the cyclophilin-D component of the mitochondrial permeability transition pore. PubMed
Myocardial Ischemia[Clinical characteristics of patients diagnosed of chronic heart failure attended in Primary Care. The CARDIOPRES study] PubMed
Myocardial Reperfusion InjuryExtracellular cyclophilin A may be a potential target to protect against myocardial reperfusion injury. PubMed
MyocarditisCyclophilin A affects inflammation, virus elimination and myocardial fibrosis in coxsackievirus B3-induced myocarditis. PubMed
Neoplasm MetastasisAssociation of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma. PubMed
Neoplasm MetastasisCyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9. PubMed
Neoplasm MetastasisFKBP38-Bcl-2 interaction: a novel link to chemoresistance. PubMed
Neoplasm MetastasisLocalization of sporadic neuroendocrine tumors by gene expression analysis of their metastases. PubMed
Neoplasm MetastasisModulated T-complex protein 1 ? and peptidyl-prolyl cis-trans isomerase B are two novel indicators for evaluating lymph node metastasis in colorectal cancer: Evidence from proteomics and bioinformatics. PubMed
Neoplasms1-(2,6-Dibenzyloxybenzoyl)-3-(9H-fluoren-9-yl)-urea: A novel cyclophilin A allosteric activator. PubMed
NeoplasmsA cyclophilin B gene encodes antigenic epitopes recognized by HLA-A24-restricted and tumor-specific CTLs. PubMed
NeoplasmsA molecular link between AKT regulation and chemotherapeutic response. PubMed
NeoplasmsA molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography. PubMed
NeoplasmsActivation and accumulation of B cells in TACI-deficient mice. PubMed
NeoplasmsActivation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition. PubMed
NeoplasmsAdipokine gene transcription level in adipose tissue of runt piglets. PubMed
NeoplasmsAge-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody defic