Information on EC 5.2.1.12 - zeta-carotene isomerase:
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The lowest common taxonomy group for this enzyme is: Magnoliophyta

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EC NUMBERCOMMENTARY
5.2.1.12-

RECOMMENDED NAMEGeneOntology No.
zeta-carotene isomeraseGO:0090471

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene
show the reaction diagram		----
9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene
show the reaction diagram		-Arabidopsis thaliana-713315
9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene
show the reaction diagram		-Zea maysB4FHU1713315

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

PATHWAYKEGG LinkMetaCyc Link
trans-lycopene biosynthesis II (plants)-PWY-6475

SYSTEMATIC NAMEIUBMB Comments
9,15,9'-tricis-zeta-carotene cis-trans-isomeraseInvolved in carotenoid biosynthesis.

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
15-cis-zeta-carotene isomeraseArabidopsis thaliana--713315
15-cis-zeta-carotene isomeraseZea maysB4FHU1-713315
At1g10830Arabidopsis thaliana-gene name713315
Z-ISOZea mays--713306, 713315
Z-ISOArabidopsis thaliana--713315

CAS REGISTRY NUMBERCOMMENTARY
No entries in this field

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Arabidopsis thaliana-713315--Manually annotated by BRENDA team
Zea mays-713306--Manually annotated by BRENDA team
Zea mays-713315B4FHU1UniprotManually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
malfunctionZea mays-in absence of light, the 9,15,9'-tri-cis-zeta-carotene isomer accumulates in etiolated leaves and roots of maize plants carrying the recessive y9 allele in comparison to normal carotenoid composition in light-exposed y9 leaves713306
physiological functionArabidopsis thaliana-involved in carotenoid biosynthesis713315
physiological functionZea maysB4FHU1involved in carotenoid biosynthesis713315

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
9,15,9'-tricis-zeta-carotene9,9'-dicis-zeta-carotene
show the reaction diagram		Zea mays--713306--?
9,15,9'-tricis-zeta-carotene9,9'-dicis-zeta-carotene
show the reaction diagram		Zea maysB4FHU1-713315--?
9,15,9'-tricis-zeta-carotene9,9'-dicis-zeta-carotene
show the reaction diagram		Arabidopsis thaliana--713315--?
9,15,9'-tricis-zeta-carotene9,9'-dicis-zeta-carotene
show the reaction diagram		Zea maysB4FHU1involved in carotenoid biosynthesis713315--?
9,15,9'-tricis-zeta-carotene9,9'-dicis-zeta-carotene
show the reaction diagram		Arabidopsis thaliana-involved in carotenoid biosynthesis713315--?

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
9,15,9'-tricis-zeta-carotene9,9'-dicis-zeta-carotene
show the reaction diagram		Zea mays--713306--
9,15,9'-tricis-zeta-carotene9,9'-dicis-zeta-carotene
show the reaction diagram		Zea maysB4FHU1involved in carotenoid biosynthesis713315--
9,15,9'-tricis-zeta-carotene9,9'-dicis-zeta-carotene
show the reaction diagram		Arabidopsis thaliana-involved in carotenoid biosynthesis713315--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
No entries in this field

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
No entries in this field

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
No entries in this field

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
leafArabidopsis thaliana--713315Manually annotated by BRENDA team
leafZea maysB4FHU1-713315Manually annotated by BRENDA team

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
No entries in this field

PDBSCOPCATHORGANISM
No entries in this field

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
No entries in this field

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
expression in Escherichia coliArabidopsis thaliana-713315
expression in Escherichia coliZea maysB4FHU1713315

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISMLINK TO PUBMEDSOURCE
713306Li, F.; Murillo, C.; Wurtzel, E.T.Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerizationPlant Physiol.1441181-11892007Zea mays PubMed
713315Chen, Y.; Li, F.; Wurtzel, E.T.Isolation and characterization of the Z-ISO gene encoding a missing component of carotenoid biosynthesis in plantsPlant Physiol.15366-792010Arabidopsis thaliana, Zea mays PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 5.2.1.12)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)