Information on EC 4.3.1.3 - histidine ammonia-lyase:

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, unidentified
The following organisms could not be found in the NCBI Taxonomy. Hence, they are not considered for the taxonomic range: toad

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EC NUMBERCOMMENTARY
4.3.1.3-

RECOMMENDED NAMEGeneOntology No.
histidine ammonia-lyaseGO:0004397

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
L-histidine = urocanate + NH3
show the reaction diagram
----
L-histidine = urocanate + NH3
show the reaction diagram
mechanismPseudomonas putida-34307, 34310
L-histidine = urocanate + NH3
show the reaction diagram
mechanismBacillus subtilis, Comamonas testosteroni, Enterobacter aerogenes, Homo sapiens, Pseudomonas aeruginosa-5997
L-histidine = urocanate + NH3
show the reaction diagram
mechanismPseudomonas fluorescens-34288, 5997
L-histidine = urocanate + NH3
show the reaction diagram
mechanismPseudomonas sp.-34286, 5997
L-histidine = urocanate + NH3
show the reaction diagram
mechanismRattus norvegicus-34282, 34288, 5997
L-histidine = urocanate + NH3
show the reaction diagram
mechanismSalmonella enterica subsp. enterica serovar Typhimurium, toad-5997
L-histidine = urocanate + NH3
show the reaction diagram
mechanismPseudomonas fluorescens A.3.12--

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
DeaminationHomo sapiens--691650, 693378
eliminationPseudomonas putida--679156
elimination--of NH3, C-N bond cleavage-
elimination of NH3Homo sapiens--651573
elimination of NH3Rattus norvegicus--653093
elimination of NH3Pseudomonas putida--651111, 651437, 651565, 653903

PATHWAYKEGG LinkMetaCyc Link
histidine degradation I-HISDEG-PWY
histidine degradation II-PWY-5028
histidine degradation III-PWY-5030
histidine degradation VI-HISHP-PWY
Histidine metabolism00340 -
Metabolic pathways01100 -

SYSTEMATIC NAMEIUBMB Comments
L-histidine ammonia-lyase (urocanate-forming)This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.23 (tyrosine ammonia-lyase), EC 4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase). The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [4]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [5]. This enzyme catalyses the first step in the degradation of histidine and the product, urocanic acid, is further metabolized to glutamate [2,3].

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
ammonia-lyase, histidine----
HAL----
HALRattus norvegicus--653093
HALPseudomonas putida--651111, 651437, 651565, 653903, 679156
HALHomo sapiens--651573, 691650
histidase----
histidaseHomo sapiens--665126, 691650, 693378
histidase, Hut----
histidinase----
histidine alpha-deaminase----
histidine ammonia lyaseHomo sapiens--693378
histidine ammonia-lyasePseudomonas putida--679156
histidine ammonia-lyaseHomo sapiens--691650
histidine deaminase----
L-HAL----
L-histidase----
L-histidine NH3-lyase----

CAS REGISTRY NUMBERCOMMENTARY
9013-75-6-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Achromobacter liquidum-34287--Manually annotated by BRENDA team
Achromobacter liquidum IAM 1667-34287--Manually annotated by BRENDA team
Bacillus cereus-34287--Manually annotated by BRENDA team
Bacillus subtilis-34279, 34287, 34304, 5997, 34297--Manually annotated by BRENDA team
Bacillus subtilis Marburg 168-34297--Manually annotated by BRENDA team
Bacillus subtilis W23G-34279--Manually annotated by BRENDA team
Cavia porcellus-34274, 34284, 34294--Manually annotated by BRENDA team
Chlamydomonas reinhardtii-666649--Manually annotated by BRENDA team
Chlamydomonas reinhardtii CCAP 11/32A-666649--Manually annotated by BRENDA team
Comamonas testosteroni-34287, 5997--Manually annotated by BRENDA team
Emericella nidulans-34292--Manually annotated by BRENDA team
Enterobacter aerogenes-34279, 5997--Manually annotated by BRENDA team
Helianthus sp.-34287--Manually annotated by BRENDA team
Homo sapiens-34280, 34281, 5997, 651573, 691650, 693378, 665126--Manually annotated by BRENDA team
Klebsiella pneumoniae subsp. pneumoniae-34296, 34304--Manually annotated by BRENDA team
Lysinibacillus sphaericus-34304--Manually annotated by BRENDA team
Lysinibacillus sphaericus 2362-34304--Manually annotated by BRENDA team
Mus musculus-34308--Manually annotated by BRENDA team
Mycobacterium avium-34287--Manually annotated by BRENDA team
Oncorhynchus mykiss-34293--Manually annotated by BRENDA team
Pseudomonas aeruginosa-34278, 34287, 5997--Manually annotated by BRENDA team
Pseudomonas fluorescens-34274, 34287, 34288, 34299, 5997--Manually annotated by BRENDA team
Pseudomonas fluorescens A.3.12-5997--Manually annotated by BRENDA team
Pseudomonas putida-34278, 34280, 34287, 34305, 34306, 34307, 34309, 651437, 651565, 663816, 679156, 715968, 716438, 34283, 34302, 34302, 5766--Manually annotated by BRENDA team
Pseudomonas putida-34310, 651111, 653903P21310UniprotManually annotated by BRENDA team
Pseudomonas putida A.3.12-34283--Manually annotated by BRENDA team
Pseudomonas putida PRS1-34302--Manually annotated by BRENDA team
Pseudomonas sp.-34276, 34278, 34285, 34286, 34287, 34291, 34302, 5997, 34277, 34280, 5997--Manually annotated by BRENDA team
Rattus norvegicus-34282, 34288, 34289, 34283, 34287, 5997, 666902, 34284, 34308, 653093--Manually annotated by BRENDA team
Salmonella enterica subsp. enterica serovar Typhimurium-34279, 34287, 5997--Manually annotated by BRENDA team
Scombridae-34293--Manually annotated by BRENDA team
Spinacia oleracea-34287--Manually annotated by BRENDA team
Streptomyces griseus-34298, 34301, 34303--Manually annotated by BRENDA team
Streptomyces griseus NRRL B-2682-34301--Manually annotated by BRENDA team
toad-5997--Manually annotated by BRENDA team
unidentified-34300--Manually annotated by BRENDA team
Vibrio cholerae-34287--Manually annotated by BRENDA team
Vicia faba-34290--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-fluorohistidine2-fluorourocanate + NH3
show the reaction diagram
Pseudomonas sp.--34286-34286?
4-fluoro-DL-histidine4-fluorourocanate + NH3
show the reaction diagram
Pseudomonas sp.-very poor substrate34286-34286r
4-fluorohistidine4-fluorourocanate + NH3
show the reaction diagram
Pseudomonas fluorescens--34288--?
4-nitro-L-histidine4-nitrourocanate + NH3
show the reaction diagram
Pseudomonas fluorescens--34288--?
DL-histidineurocanate + NH3
show the reaction diagram
Pseudomonas sp.--34286-34286?
L-aspartatefumarate + NH3
show the reaction diagram
Pseudomonas putida--716438--?
L-histidineurocanate + NH3
show the reaction diagram
Homo sapiens--651573-651573r
L-histidineurocanate + NH3
show the reaction diagram
Rattus norvegicus--653093-653093r
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida--679156--?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida--651111-651111r
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida--651437-651437r
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida--651565-651565r
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida--653903-653903r
L-histidineurocanate + NH3
show the reaction diagram
Salmonella enterica subsp. enterica serovar Typhimurium-natural substrate5997-5997?
L-histidineurocanate + NH3
show the reaction diagram
Salmonella enterica subsp. enterica serovar Typhimurium-natural substrate34279-34279?
L-histidineurocanate + NH3
show the reaction diagram
Salmonella enterica subsp. enterica serovar Typhimurium-natural substrate34287-34287?
L-histidineurocanate + NH3
show the reaction diagram
Vicia faba-natural substrate34290-34290?
L-histidineurocanate + NH3
show the reaction diagram
Cavia porcellus-natural substrate34274-34274?
L-histidineurocanate + NH3
show the reaction diagram
Cavia porcellus-natural substrate34284-34284?
L-histidineurocanate + NH3
show the reaction diagram
Cavia porcellus-natural substrate34294-34294?
L-histidineurocanate + NH3
show the reaction diagram
Bacillus subtilis-natural substrate5997-5997?
L-histidineurocanate + NH3
show the reaction diagram
Bacillus subtilis-natural substrate34279-34279?
L-histidineurocanate + NH3
show the reaction diagram
Bacillus subtilis-natural substrate34287-34287?
L-histidineurocanate + NH3
show the reaction diagram
Bacillus subtilis-natural substrate34297-34297?
L-histidineurocanate + NH3
show the reaction diagram
Bacillus subtilis-natural substrate34304-34304?
L-histidineurocanate + NH3
show the reaction diagram
Mus musculus-natural substrate34308-34308?
L-histidineurocanate + NH3
show the reaction diagram
Homo sapiens-natural substrate5997-5997?
L-histidineurocanate + NH3
show the reaction diagram
Homo sapiens-natural substrate34280-34280?
L-histidineurocanate + NH3
show the reaction diagram
Homo sapiens-natural substrate34281-34281?
L-histidineurocanate + NH3
show the reaction diagram
Rattus norvegicus-natural substrate5997-5997?
L-histidineurocanate + NH3
show the reaction diagram
Rattus norvegicus-natural substrate34282-34282?
L-histidineurocanate + NH3
show the reaction diagram
Rattus norvegicus-natural substrate34283-34283?
L-histidineurocanate + NH3
show the reaction diagram
Rattus norvegicus-natural substrate34284-34284?
L-histidineurocanate + NH3
show the reaction diagram
Rattus norvegicus-natural substrate34287-34287?
L-histidineurocanate + NH3
show the reaction diagram
Rattus norvegicus-natural substrate34288-34288?
L-histidineurocanate + NH3
show the reaction diagram
Rattus norvegicus-natural substrate34289-34289?
L-histidineurocanate + NH3
show the reaction diagram
Rattus norvegicus-natural substrate34308-34308?
L-histidineurocanate + NH3
show the reaction diagram
Emericella nidulans-natural substrate34292-34292?
L-histidineurocanate + NH3
show the reaction diagram
Spinacia oleracea-natural substrate34287-34287?
L-histidineurocanate + NH3
show the reaction diagram
Lysinibacillus sphaericus-natural substrate34304-34304?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas fluorescens-natural substrate5997-5997?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas fluorescens-natural substrate34274-34274?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas fluorescens-natural substrate34287-34287?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas fluorescens-natural substrate34288-34288?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas fluorescens-natural substrate34299-34299?
L-histidineurocanate + NH3
show the reaction diagram
Enterobacter aerogenes-natural substrate5997-5997?
L-histidineurocanate + NH3
show the reaction diagram
Enterobacter aerogenes-natural substrate34279-34279?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas aeruginosa-natural substrate5997-5997?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas aeruginosa-natural substrate34278-34278?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas aeruginosa-natural substrate34287-34287?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas sp.-natural substrate5997-5997?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas sp.-natural substrate34276-34276?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas sp.-natural substrate34277-34277?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas sp.-natural substrate34278-34278?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas sp.-natural substrate34280-34280?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas sp.-natural substrate34285-34285?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas sp.-natural substrate34287-34287?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas sp.-natural substrate34291-34291?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas sp.-natural substrate34302-34302?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas sp.-natural substrate34286-34286r
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida-natural substrate5766-5766-
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida-natural substrate34278-34278-
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida-natural substrate34280-34280-
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida-natural substrate34283-34283-
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida-natural substrate34287-34287-
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida-natural substrate34302-34302-
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida-natural substrate34306-34306-
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida-natural substrate34307-34307r
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida-natural substrate34309-34309r
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putidaP21310natural substrate34310-34310r
L-histidineurocanate + NH3
show the reaction diagram
Mycobacterium avium, Bacillus cereus-natural substrate34287-34287?
L-histidineurocanate + NH3
show the reaction diagram
Streptomyces griseus-natural substrate34298-34298?
L-histidineurocanate + NH3
show the reaction diagram
Streptomyces griseus-natural substrate34301-34301?
L-histidineurocanate + NH3
show the reaction diagram
Streptomyces griseus-natural substrate34303-34303?
L-histidineurocanate + NH3
show the reaction diagram
Comamonas testosteroni-natural substrate5997-5997?
L-histidineurocanate + NH3
show the reaction diagram
Comamonas testosteroni-natural substrate34287-34287?
L-histidineurocanate + NH3
show the reaction diagram
Oncorhynchus mykiss-natural substrate34293-34293?
L-histidineurocanate + NH3
show the reaction diagram
Vibrio cholerae-natural substrate34287-34287?
L-histidineurocanate + NH3
show the reaction diagram
toad-natural substrate5997-5997?
L-histidineurocanate + NH3
show the reaction diagram
Achromobacter liquidum, Helianthus sp.-natural substrate34287-34287?
L-histidineurocanate + NH3
show the reaction diagram
Scombridae-natural substrate34293-34293?
L-histidineurocanate + NH3
show the reaction diagram
Klebsiella pneumoniae subsp. pneumoniae-natural substrate34304-34304-
L-histidineurocanate + NH3
show the reaction diagram
unidentified-natural substrate34300-34300?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida-natural substrate34305trans-urocanate34305-
L-histidineurocanate + NH3
show the reaction diagram
Klebsiella pneumoniae subsp. pneumoniae-natural substrate34296enzyme catalyzes amination under extreme condition, 4 M NH4OH, pH 1034296r
L-histidineurocanate + NH3
show the reaction diagram
Rattus norvegicus-non-oxidative deamination34308-34308?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida-non-oxidative deamination34302-34302-
L-histidineurocanate + NH3
show the reaction diagram
Streptomyces griseus-non-oxidative deamination34301-34301?
L-histidineurocanate + NH3
show the reaction diagram
Streptomyces griseus-non-oxidative deamination34303-34303?
L-histidineurocanate + NH3
show the reaction diagram
Oncorhynchus mykiss-non-oxidative deamination34293-34293?
L-histidineurocanate + NH3
show the reaction diagram
Achromobacter liquidum IAM 1667-natural substrate34287-34287?
L-histidineurocanate + NH3
show the reaction diagram
Bacillus subtilis Marburg 168-natural substrate34297-34297?
L-histidineurocanate + NH3
show the reaction diagram
Lysinibacillus sphaericus 2362-natural substrate34304-34304?
L-histidineurocanate + NH3
show the reaction diagram
Streptomyces griseus NRRL B-2682-natural substrate, non-oxidative deamination34301-34301?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas fluorescens A.3.12-natural substrate5997-5997?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida A.3.12-natural substrate34283-34283-
L-histidineurocanate + NH3
show the reaction diagram
Bacillus subtilis W23G-natural substrate34279-34279?
L-histidineurocanate + NH3
show the reaction diagram
Pseudomonas putida PRS1-natural substrate, non-oxidative deamination34302-34302-
L-histidinetrans-urocanic acid + NH3
show the reaction diagram
Homo sapiens--693378main ultraviolet light absorption factor of the stratum corneum, component of the natural moisturizing factor (mixture of low-molecular weight, watersoluble substances that maintain the proper hydration of the stratum corneum), trans-urocanic acid is implicated in photoaging of human skin-?
L-histidinetrans-urocanic acid + NH3
show the reaction diagram
Homo sapiens-enzyme catalyzes the formation of urocanic acid in the skin, modifies risk of basal cell carcinoma and squamous cell carcinoma691650urocanic acid is a UV radiation-absorbing molecule in the stratum corneum-?
L-histidine methyl esterurocanate methyl ester
show the reaction diagram
Pseudomonas putida, Pseudomonas putida PRS1-cloned enzyme34302cloned enzyme34302?
additional information?-Rattus norvegicus--5997, 34308---
additional information?-Pseudomonas fluorescens--5997---
additional information?-Pseudomonas putida--34309---
additional information?-Pseudomonas putida--34283--?
additional information?-Lysinibacillus sphaericus-catabolite repression of enzyme biosynthesis by acetate34304---
additional information?-Mus musculus-deficiency of enzyme results in histidinemia34308---
additional information?-Homo sapiens-deficiency of enzyme results in histidinemia5997, 34281---
additional information?-Pseudomonas putida-Ser-143 is an essential active site residue in the enzyme34306---
additional information?-Streptomyces griseus-histidine utilization is controlled posttranslationally by an activation cascade that involves at least two regulatory proteins34298---
additional information?-unidentified-inductive and repressive effects of carbon and nitrogen on enzyme activity in a black chernozemic soil34300---
additional information?-Cavia porcellus, Pseudomonas fluorescens-pathway of histidine metabolism, enzymatical synthesis of urocanic acid34274---
additional information?-Rattus norvegicus-pathway of histidine catabolism34282---
additional information?-Emericella nidulans-use of histidine as a nitrogen source is regulated by nitrogen metabolite repression control of histidase synthesis34292---
additional information?-Lysinibacillus sphaericus 2362-catabolite repression of enzyme biosynthesis by acetate34304---
additional information?-Pseudomonas fluorescens A.3.12--5997---
additional information?-Pseudomonas putida A.3.12--34283--?

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
No entries in this field

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
AMPVicia faba-0.016 mM, maximal activity34290 2D-image
vitamin B12Vicia faba-0.0033 mM, maximal activity34290 2D-image

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
Ca2+Rattus norvegicus-activates at a concentration of 0.1 mM34284
Cd2+Pseudomonas sp.-stimulates oxidized and reduced enzyme34276
Cd2+Rattus norvegicus-activates at a concentration of 0.1 mM34284
Cd2+Pseudomonas sp.--34291
Fe2+Pseudomonas sp.-required for optimal activity34276
Mg2+Rattus norvegicus-activates at a concentration of 0.1 mM34284
Mg2+Pseudomonas putida--34302
Mn2+Pseudomonas sp.-stimulates oxidized and reduced enzyme34276
Mn2+Pseudomonas sp.-enhances activity34278
Mn2+Rattus norvegicus-activates at a concentration of 0.1 mM34284
Mn2+Vicia faba-required34290
Mn2+Pseudomonas sp.--34291
Ni2+Rattus norvegicus-activates at a concentration of 0.1 mM34284
Ni2+Pseudomonas putida--34302
Zn2+Pseudomonas sp.-required for optimal activity34276
Zn2+Rattus norvegicus-activates at a concentration of 0.1 mM34284
Zn2+Cavia porcellus--34284, 34294
Zn2+Pseudomonas putida, Pseudomonas sp.--34302
Mn2+Chlamydomonas reinhardtii-0.1 mM, activation to 124.5% of control666649
additional informationPseudomonas sp.--34276

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
(2E)-3-(1-benzofuran-2-yl)prop-2-enoic acidPseudomonas putida--679156 2D-image
(2E)-3-(1-benzofuran-3-yl)prop-2-enoic acidPseudomonas putida--679156 2D-image
(2E)-3-(1-benzothiophen-2-yl)prop-2-enoic acidPseudomonas putida--679156 2D-image
(2E)-3-(1-benzothiophen-3-yl)prop-2-enoic acidPseudomonas putida--679156 2D-image
(2E)-3-(1-methyl-1H-indol-3-yl)prop-2-enoic acidPseudomonas putida--679156 2D-image
(2E)-3-(1H-indol-3-yl)prop-2-enoic acidPseudomonas putida--679156 2D-image
(2E)-3-(3-methylfuran-2-yl)prop-2-enoic acidPseudomonas putida--679156 2D-image
(2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acidPseudomonas putida--679156 2D-image
(2E)-3-furan-2-ylprop-2-enoic acidPseudomonas putida--679156 2D-image
(2E)-3-thiophen-2-ylprop-2-enoic acidPseudomonas putida--679156 2D-image
1,2,4-triazole-DL-alanineAchromobacter liquidum-competitive34287 2D-image
1-amino-2-imidazol-4'-ylethylphosphonic acidPseudomonas putida-reversible, competitive, 1 mM: complete inhibition34305 2D-image
1-MethyltryptophanPseudomonas putida--679156 2D-image
2,3 butanedioneStreptomyces griseus--34303 2D-image
2-mercaptoethanolRattus norvegicus-inhibition at concentrations above 10 mM, reversed by addition of metal ion34284 2D-image
2-methyl-DL-histidineAchromobacter liquidum-competitive34287 2D-image
2-thiazolyl-DL-alanineAchromobacter liquidum-competitive34287 2D-image
3-(1-benzofuran-2-yl)alaninePseudomonas putida--679156 2D-image
3-(1-benzofuran-3-yl)alaninePseudomonas putida--679156 2D-image
3-(1-benzothiophen-2-yl)alaninePseudomonas putida--679156 2D-image
3-(1-benzothiophen-3-yl)alaninePseudomonas putida--679156 2D-image
3-(3-methylthiophen-2-yl)alaninePseudomonas putida--679156 2D-image
3-furan-2-ylalaninePseudomonas putida--679156 2D-image
3-methyl-L-histidineAchromobacter liquidum-competitive34287 2D-image
3-thiophen-2-ylalaninePseudomonas putida--679156 2D-image
5,5'-dithiobis(2-nitrobenzoic acid)Pseudomonas sp.-protection of reduced enzyme by Cd2+ against inactivation34276 2D-image
5,5'-dithiobis(2-nitrobenzoic acid)Cavia porcellus--34294 2D-image
8-methoxypsoralenPseudomonas putida-noncompetitive. Irradiation of 8-methoxypsoralen with broadband UVA and broadband UVA/UVB results in uncompetitive inhibition due to psoralen-oxidized photoproducts716438 2D-image
all-trans retinoic acidHomo sapiens-1 microM suppresses histidase expression almost completely, levels of histidase mRNA expression in the presence of all-trans retinoic acid are significantly lower on day 2 of post-confluence and at all later time points during keratinocyte differentiation693378 2D-image
alpha-methyl-DL-histidineAchromobacter liquidum-competitive34287 2D-image
Ba2+Achromobacter liquidum-1 mM34287 2D-image
beta-imidazole lactic acidAchromobacter liquidum-competitive34287 2D-image
biguanidePseudomonas sp.--34278 2D-image
bisulfitePseudomonas sp.-sodiumbisulfite34278 2D-image
bisulfitePseudomonas putida-10 mM, 95% loss of activity after 90 min, 0.1 mM 1-amino-2-imidazol-4'-ylethylphosphoric acid protects34305 2D-image
bisulfitePseudomonas putida--34278, 34306 2D-image
CN-Cavia porcellus-0.01 M, 40% inhibition34274 2D-image
CN-Streptomyces griseus-KCN34301 2D-image
CN-Pseudomonas putida, Pseudomonas sp.-KCN34278, 34302 2D-image
CN-Pseudomonas putida--34305 2D-image
CN-Pseudomonas putida-irreversible34306 2D-image
Co3+Chlamydomonas reinhardtii-0.1 mM, 95% inhibition666649 2D-image
Cu2+Chlamydomonas reinhardtii-0.1 mM, 70% inhibition666649 2D-image
cyanideChlamydomonas reinhardtii-50 mM histidinol phosphate, 5 mM L-histidine and 5 mM Mn2+ protects666649 2D-image
D-alpha-hydrazinohistidineOncorhynchus mykiss-competitive34293 2D-image
D-alpha-hydrazinoimidazolylpropionic acidRattus norvegicus-strong34288 2D-image
D-alpha-hydrazinoimidazolylpropionic acidRattus norvegicus-inactivates in vivo34289 2D-image
D-CysteinePseudomonas sp.-in the presence of Cd2+34285 2D-image
D-histidinePseudomonas fluorescens, Rattus norvegicus-competitive34288 2D-image
D-histidineOncorhynchus mykiss-competitive34293 2D-image
D-histidineStreptomyces griseus-competitive34301 2D-image
D-histidinePseudomonas putida-cloned enzyme, reversible competitive34302 2D-image
dithiothreitolCavia porcellus, Rattus norvegicus--34284 2D-image
dithiothreitolCavia porcellus-20 mM, liver and epidermal enzyme, restored by addition with Zn2+34294 2D-image
DL-alpha-hydrazinoimidazolylpropionic acidRattus norvegicus-70% irreversible inactivation in vivo34289 2D-image
DL-pyrazolyl-3-alanineRattus norvegicus-5.0 mM34288 2D-image
EDTACavia porcellus-0.001 mM: 50% inhibition, 0.01 mM, complete inhibition34274 2D-image
EDTAPseudomonas sp.-potent inhibitor of the reduced enzyme; reduced enzyme34276 2D-image
EDTACavia porcellus, Rattus norvegicus--34284 2D-image
EDTAPseudomonas putida--34278, 34287 2D-image
EDTAPseudomonas sp., Rattus norvegicus-reversed by addition of divalent cations34287 2D-image
EDTACavia porcellus-0.04 mM, liver and epidermal enzyme, restored by incubation with Zn2+34294 2D-image
EDTAPseudomonas putida-0.005 mM, 75% decrease of activity34302 2D-image
EDTAPseudomonas sp.--34278, 34302 2D-image
Fe2+Chlamydomonas reinhardtii-0.1 mM, 60% inhibition666649 2D-image
Fe3+Achromobacter liquidum-1 mM34287 2D-image
Fe3+Chlamydomonas reinhardtii-0.1 mM, 60% inhibition666649 2D-image
formyl-L-histidineAchromobacter liquidum-competitive34287 2D-image
glycineCavia porcellus-0.02 M glycine buffer, 40% inhibition. Inhibition can be overcome by addition of cations, including Mn2+, Ca2+, and Mg2+34274 2D-image
glycineRattus norvegicus--34288 2D-image
H2O2Achromobacter liquidum--34287 2D-image
histidinol phosphateStreptomyces griseus-competitive34301, 34303 2D-image
hydroxylaminePseudomonas sp.--34278 2D-image
hydroxymethylimidazoleAchromobacter liquidum-competitive34287-
imidazol-3-ylpyruvateOncorhynchus mykiss-uncompetitive34293-
imidazoleAchromobacter liquidum-noncompetitive34287 2D-image
interleukin-1alphaHomo sapiens-treatment of IL-1a reduces histidase expression, the suppressive effect can be reverted by concomitant treatment with interleukin-1alpha receptor antagonist693378-
L-1-methylhistidineRattus norvegicus-5.0 mM34288 2D-image
L-alanineRattus norvegicus-5.0 mM34288 2D-image
L-alpha-hydrazinoimidazolylpropionic acidRattus norvegicus-competitive34289-
L-cysteinPseudomonas putida-50 mM, complete inaction at basic pH in the presence of O2 is due to a covalent modification of the enzyme651565 2D-image
L-cysteinPseudomonas putida-10 mM, complete inactivation at pH higher than 10 in the presence of O2653903 2D-image
L-cysteinePseudomonas sp.-competitive in the presence of EDTA; in the presence of Cd2+; irreversible in the presence of O234285 2D-image
L-cysteineAchromobacter liquidum--34287 2D-image
L-cysteinePseudomonas putida--34278, 34287 2D-image
L-cysteinePseudomonas putida-competitive, cloned enzyme34302 2D-image
L-cysteinePseudomonas sp.--34278, 34287, 34302 2D-image
L-cysteinePseudomonas putida-irreversible34306 2D-image
L-cysteinePseudomonas putida-irreversible in the presence of O234307 2D-image
L-cysteinePseudomonas putida-10 mM, irreversible inactivation651111 2D-image
L-cysteinePseudomonas putida-10 mM, complete inactivation after 3 h under aerobic conditions651437 2D-image
L-histidine hydrazideAchromobacter liquidum-noncompetitive34287 2D-image
L-histidine hydroxamateAchromobacter liquidum, Rattus norvegicus-competitive34287 2D-image
L-histidine hydroxamateRattus norvegicus-competitive; strong34288 2D-image
L-histidine hydroxamateOncorhynchus mykiss-competitive34293 2D-image
L-histidinemethyl esterAchromobacter liquidum, Rattus norvegicus--34287 2D-image
L-histidinemethyl esterRattus norvegicus-5.0 mM34288 2D-image
L-HistidinolAchromobacter liquidum-competitive34287 2D-image
L-HistidinolRattus norvegicus-competitive34287, 34288 2D-image
L-homocysteinePseudomonas sp.-irreversible in the presence of O2 and high pH34285 2D-image
L-N-gamma-methylhistidinePseudomonas sp.-weak competitive34286 2D-image
L-tyrosinePseudomonas sp.-heat-purified enzyme, at low concentrations, pH 7-834278 2D-image
N-acetyl-L-histidineRattus norvegicus-5.0 mM34288 2D-image
N-ethylmaleimideStreptomyces griseus-1 mM, partial34303 2D-image
NaBH4Achromobacter liquidum--34287 2D-image
NaBH4Pseudomonas sp.--34277, 34278, 34287 2D-image
NaBH4Rattus norvegicus--34284, 34287 2D-image
NitromethaneRattus norvegicus--34284 2D-image
NitromethaneRattus norvegicus-inactivates enzyme in vivo34289 2D-image
norhistidinePseudomonas putida--679156-
O2Pseudomonas putida-irreversible34307 2D-image
p-fluoro-L-histidinePseudomonas sp.-competitive34286-
p-fluoro-L-histidinePseudomonas fluorescens-competitive34288-
p-hydroxyphenylpyruvatePseudomonas sp.-heat-purified enzyme, at low concentrations, pH 7-834278 2D-image
p-mercuribenzoatePseudomonas sp.-inhibits mercaptoethanol-activated enzyme34278 2D-image
p-mercuribenzoateRattus norvegicus-0.01 mM, complete inhibition, partially reversed by addition of histidine34284 2D-image
p-nitro-L-histidinePseudomonas fluorescens-competitive34288-
Pb2+Achromobacter liquidum-1 mM34287 2D-image
PhenylglyoxalStreptomyces griseus-protection by histidinol phosphate34303 2D-image
phenylhydrazinePseudomonas sp.--34278 2D-image
Sodium diphosphatePseudomonas sp.--34278 2D-image
TGF-alphaHomo sapiens-most pronounced effect, leads to almost complete suppression of histidase expression693378-
TNF-alphaHomo sapiens-suppresses the expression of histidase693378-
tryptophanPseudomonas putida--679156 2D-image
UrocanatePseudomonas aeruginosa--34278 2D-image
UrocanatePseudomonas sp.-heat-purified enzyme, at low concentrations, pH 7-834278 2D-image
UrocanateEmericella nidulans--34292 2D-image
MethylglyoxalStreptomyces griseus--34303 2D-image
additional informationPseudomonas sp.--34276, 34285-
additional informationRattus norvegicus--34284, 34288, 34289-

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
2-mercaptoethanolPseudomonas sp.-activates34278 2D-image
2-mercaptoethanolRattus norvegicus-activates at concentrations up to 10 mM34284 2D-image
dithiothreitolPseudomonas sp.-activates34278 2D-image
EstrogenHomo sapiens-transcriptional activator of histidase expression691650 2D-image
glucocorticoidHomo sapiens-transcriptional activator of histidase expression691650-
GSHPseudomonas sp.-activates34278 2D-image
GSHCavia porcellus--34284 2D-image
GSHRattus norvegicus-activates34284 2D-image
Sulfhydryl compoundsPseudomonas sp.-activates34277 2D-image
Sulfhydryl compoundsVicia faba-activates34290 2D-image
GSHCavia porcellus-increases at concentrations below 5 mM, pH 7.434294 2D-image
additional informationHomo sapiens-detection of increased trans-urocanic acid levels in the epidermis of patients with psoriasis and in UV-treated epidermis indicates that epidermal histidase may be subject to regulation by endogenous and exogenous factors; expression of histidase strongly increases at the mRNA and protein levels during differentiation of primary keratinocytes in vitro; treatment of keratinocytes with UVA and UVB does not significantly change the expression level of histidase693378-

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
20-2-fluorohistidinePseudomonas sp.--34286 2D-image
1.25-4-fluoro-DL-histidinePseudomonas sp.-in the presence of 0.1 mM CdCl234286 2D-image
6.4-4-fluoro-DL-histidinePseudomonas sp.-in the presence of 1 mM EDTA34286 2D-image
5-4-fluorourocanatePseudomonas sp.--34286 2D-image
2.7-DL-histidinePseudomonas sp.-in the presence of 0.1 mM CdCl234286 2D-image
10-DL-histidinePseudomonas sp.-in the presence of 1 mM EDTA34286 2D-image
0.2-L-histidineOncorhynchus mykiss-pH 9, kidney enzyme34293 2D-image
0.36-L-histidineCavia porcellus-pH 9.2 and pH 7.0, epidermal enzyme34294 2D-image
0.45-L-histidineRattus norvegicus-pH 9.034288 2D-image
0.55-L-histidineCavia porcellus-pH 9.2, liver enzyme34294 2D-image
0.6-L-histidineStreptomyces griseus--34301 2D-image
0.88-L-histidineStreptomyces griseus--34303 2D-image
1-L-histidineCavia porcellus-pH 7.0, liver enzyme34294 2D-image
1.2-L-histidineRattus norvegicus--34284 2D-image
1.6-L-histidinePseudomonas putida-pH 734305 2D-image
2.1-L-histidineRattus norvegicus-pH 7.234288 2D-image
3.6-L-histidineAchromobacter liquidum--34287 2D-image
3.8-L-histidinePseudomonas sp.-25C34278 2D-image
3.9-L-histidinePseudomonas putida-25C, pH 9.3651111 2D-image
5.1-L-histidinePseudomonas putida-pH 934305 2D-image
5.3-L-histidinePseudomonas putida-native enzyme, pH 9.034302 2D-image
5.8-L-histidinePseudomonas putida-cloned enzyme, pH 9.034302 2D-image
6-L-histidinePseudomonas sp.-oxidized enzyme, in the absence of added metal34276 2D-image
6.3-L-histidinePseudomonas sp.-reduced enzyme in the presence of 0.01 M EDTA34276 2D-image
6.7-L-histidineBacillus subtilis--34279 2D-image
8500-NH3Klebsiella pneumoniae subsp. pneumoniae-pH 1034296 2D-image
3-UrocanatePseudomonas sp.--34286 2D-image
100-UrocanateKlebsiella pneumoniae subsp. pneumoniae-pH 1034296 2D-image
20-L-histidinePseudomonas fluorescens-enzyme in solution or microencapsulated34299 2D-image
additional information-additional informationPseudomonas sp.--34276-
additional information-additional informationPseudomonas putida, Rattus norvegicus--34283-
additional information-additional informationPseudomonas sp.--34286-
additional information-additional informationPseudomonas fluorescens, Rattus norvegicus--34288-
additional information-additional informationOncorhynchus mykiss--34293-
additional information-additional informationPseudomonas putida--34305-
additional information-additional informationPseudomonas fluorescens, Pseudomonas sp., Rattus norvegicus--5997-
additional information-additional informationChlamydomonas reinhardtii-the enzyme does not exhibit classical Michaelis-Menten kinetics666649-

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
86-L-histidinePseudomonas putida-25C, pH 9.3651111 2D-image
255-L-histidinePseudomonas putida--34302 2D-image

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.056-(2E)-3-(1-benzofuran-2-yl)prop-2-enoic acidPseudomonas putida-competitive inhibition679156 2D-image
0.023-(2E)-3-(1-benzofuran-3-yl)prop-2-enoic acidPseudomonas putida-competitive inhibition679156 2D-image
0.039-(2E)-3-(1-benzothiophen-2-yl)prop-2-enoic acidPseudomonas putida-competitive inhibition679156 2D-image
0.053-(2E)-3-(1-benzothiophen-3-yl)prop-2-enoic acidPseudomonas putida-competitive inhibition679156 2D-image
0.026-(2E)-3-(1-methyl-1H-indol-3-yl)prop-2-enoic acidPseudomonas putida-competitive inhibition679156 2D-image
0.015-(2E)-3-(1H-indol-3-yl)prop-2-enoic acidPseudomonas putida-competitive inhibition679156 2D-image
0.018-(2E)-3-(3-methylfuran-2-yl)prop-2-enoic acidPseudomonas putida-competitive inhibition679156 2D-image
0.04-(2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acidPseudomonas putida-competitive inhibition679156 2D-image
0.033-(2E)-3-furan-2-ylprop-2-enoic acidPseudomonas putida-competitive inhibition679156 2D-image
0.041-(2E)-3-thiophen-2-ylprop-2-enoic acidPseudomonas putida-competitive inhibition679156 2D-image
0.031-1-MethyltryptophanPseudomonas putida-mixed inhibition679156 2D-image
0.025-3-(1-benzofuran-2-yl)alaninePseudomonas putida-competitive inhibition679156 2D-image
0.067-3-(1-benzofuran-3-yl)alaninePseudomonas putida-competitive inhibition679156 2D-image
0.083-3-(1-benzothiophen-2-yl)alaninePseudomonas putida-competitive inhibition679156 2D-image
0.082-3-(1-benzothiophen-3-yl)alaninePseudomonas putida-competitive inhibition679156 2D-image
0.098-3-(3-methylthiophen-2-yl)alaninePseudomonas putida-competitive inhibition679156 2D-image
0.139-3-furan-2-ylalaninePseudomonas putida-competitive inhibition679156 2D-image
0.101-3-thiophen-2-ylalaninePseudomonas putida-competitive inhibition679156 2D-image
0.001-EDTACavia porcellus--34274 2D-image
1.72-norhistidinePseudomonas putida-mixed inhibition679156-
0.05-tryptophanPseudomonas putida-mixed inhibition679156 2D-image

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
0.3427-Rattus norvegicus-native enzyme666902
1.2-Pseudomonas sp.-0.1 mM Ca2+, oxidized enzyme34276
2.3-Pseudomonas sp.-0.1 mM Mn2+, oxidized enzyme34276
2.8-Pseudomonas sp.-0.1 mM Fe2+, oxidized enzyme34276
3.2-Pseudomonas sp.--34291
3.4-Rattus norvegicus-37C, pH 9.0, 3.3 mM L-histidine5997
4.3-Pseudomonas sp.-0.1 mM Zn2+, oxidized enzyme34276
6.2-Pseudomonas sp.-0.1 mM Ca2+, reduced enzyme34276
6.8-Rattus norvegicus--34284
7-Pseudomonas sp.-0.1 mM Fe2+ or 0.1 mM Zn2+, reduced enzyme34276
9.1-Pseudomonas sp.-0.1 mM Mn2+, reduced enzyme34276
9.94-Rattus norvegicus--34288
20.7-Streptomyces griseus--34303
63-Achromobacter liquidum--34287
70.4-Pseudomonas putida-cloned enzyme34302
additional information-Cavia porcellus, Pseudomonas fluorescens--34274
additional information-Pseudomonas sp.--34276, 34277
additional information-Pseudomonas putida, Pseudomonas sp.--34278
additional information-Bacillus subtilis--34279
additional information-Rattus norvegicus--34282
additional information-Pseudomonas putida, Rattus norvegicus--34283
additional information-Cavia porcellus, Rattus norvegicus--34284
additional information-Pseudomonas sp.--34285, 34286
additional information-Rattus norvegicus--34289
additional information-Vicia faba--34290
additional information-Klebsiella pneumoniae subsp. pneumoniae--34296
additional information-Streptomyces griseus--34298
additional information-Pseudomonas fluorescens--34299
additional information-Pseudomonas putida, Pseudomonas sp.--34302
additional information-Bacillus subtilis, Klebsiella pneumoniae subsp. pneumoniae, Lysinibacillus sphaericus--34304
additional information-Pseudomonas putida--34307, 34309, 5766
additional information-Bacillus subtilis, Pseudomonas fluorescens, Pseudomonas sp., Rattus norvegicus--5997

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
7.48.2Chlamydomonas reinhardtii--666649
8.2-Achromobacter liquidum--34287
8.59.1Bacillus subtilis-maximal activity between34279
8.5-Rattus norvegicus--34288
8.89Rattus norvegicus--34284, 34287
9-Pseudomonas sp.--34278, 34287
9.2-Oncorhynchus mykiss--34293
9.3-Pseudomonas putida-activity assay679156
additional information-Homo sapiens-the activity optimum of histidase near pH 7 suggests that histidase is active predominantly in the lower, less acidic portion of the stratum corneum693378

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
6.510Rattus norvegicus-inactive below pH 6.5, 75% of maximal activity at pH 10.034288
710Rattus norvegicus-pH 7.0: 10% of maximal activity, pH 10: about 50% of maximal activity34284
7.29.4Achromobacter liquidum-half-maximal activity at pH 7.2 and at pH 9.434287
8.19.9Pseudomonas sp.-50% of maximal activity at pH 8.1 and pH 9.934278
additional information-Pseudomonas sp.--34285, 34286, 34291
additional information-Oncorhynchus mykiss--34293

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
2035Pseudomonas putida-maximal activity between34283
25-Chlamydomonas reinhardtii--666649
25-Pseudomonas putida-activity assay679156
50-Achromobacter liquidum--34287
6065Rattus norvegicus-maximal activity between34283

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
-1060Pseudomonas putida--10C: pH 9.2, assay mixture containing 21% dimethylsulfoxide remains liquid, activity is 5,8% of the activity at 30C, 60C: 20% of maximal activity34283
additional information-Pseudomonas putida, Rattus norvegicus--34283

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
adrenal cortexRattus norvegicus--34308Manually annotated by BRENDA team
ependymal epitheliumRattus norvegicus-brain34308Manually annotated by BRENDA team
epidermisHomo sapiens--34281Manually annotated by BRENDA team
epidermisRattus norvegicus-stratum corneum, skin34289Manually annotated by BRENDA team
epidermisCavia porcellus-isoenzyme; stratum corneum; stratum granulosum34294Manually annotated by BRENDA team
epidermisRattus norvegicus-stratum granulosum34308Manually annotated by BRENDA team
epidermisHomo sapiens-high expression level693378Manually annotated by BRENDA team
ganglionRattus norvegicus-i.e. Auerbach's plexus; intramuscular plexus34308Manually annotated by BRENDA team
hepatocyteRattus norvegicus-adjacent to portal triads34308Manually annotated by BRENDA team
keratinocyteHomo sapiens-epidermal693378Manually annotated by BRENDA team
kidneyOncorhynchus mykiss--34293Manually annotated by BRENDA team
kidneyRattus norvegicus--34308Manually annotated by BRENDA team
liverCavia porcellus--34274, 34284Manually annotated by BRENDA team
liverOncorhynchus mykiss, Scombridae--34293Manually annotated by BRENDA team
liverCavia porcellus-isoenzyme34294Manually annotated by BRENDA team
liverHomo sapiens, toad--5997Manually annotated by BRENDA team
liverRattus norvegicus--34282, 34284, 34288, 34289, 34308, 5997, 653093, 666902Manually annotated by BRENDA team
liverHomo sapiens-high expression level693378Manually annotated by BRENDA team
mucous glandRattus norvegicus-stomach34308Manually annotated by BRENDA team
muscleRattus norvegicus--34282Manually annotated by BRENDA team
muscleScombridae--34293Manually annotated by BRENDA team
plasmaHomo sapiens--34280Manually annotated by BRENDA team
plasmaRattus norvegicus--34282Manually annotated by BRENDA team
seedlingVicia faba--34290Manually annotated by BRENDA team
urineHomo sapiens--34280Manually annotated by BRENDA team
urineRattus norvegicus--34282Manually annotated by BRENDA team
lymphocyteHomo sapiens--691650Manually annotated by BRENDA team
additional informationChlamydomonas reinhardtii-grown axenically at 18C under continous illumination. Cells grown on ammonium as the sole nitrogen source contain no histidase activity, cells grown on histidine, on histidine and glycine, or on histidine and aspartate contain histidase and exhibited similar histidase activities. When the cells are grown on histidine and ammonium, or on histidine and succinate, or on histidine and glutamate, the production of histidase is slightly delayed and reaches a lower level than when cells were grown on histidine as the sole source of nitrogen. No histidase activity was detected when C. reinhardtii was grown in the presence of acetate666649Manually annotated by BRENDA team
additional informationChlamydomonas reinhardtii CCAP 11/32A-grown axenically at 18C under continous illumination. Cells grown on ammonium as the sole nitrogen source contain no histidase activity, cells grown on histidine, on histidine and glycine, or on histidine and aspartate contain histidase and exhibited similar histidase activities. When the cells are grown on histidine and ammonium, or on histidine and succinate, or on histidine and glutamate, the production of histidase is slightly delayed and reaches a lower level than when cells were grown on histidine as the sole source of nitrogen. No histidase activity was detected when C. reinhardtii was grown in the presence of acetate-Manually annotated by BRENDA team

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
cytosolRattus norvegicus--582934308Manually annotated by BRENDA team

PDBSCOPCATHORGANISM
2nyn, downloadSCOP (2nyn)CATH (2nyn)Anabaena variabilis (strain ATCC 29413 / PCC 7937)
3czo, downloadSCOP (3czo)CATH (3czo)Anabaena variabilis (strain ATCC 29413 / PCC 7937)
1b8f, downloadSCOP (1b8f)CATH (1b8f)Pseudomonas putida
1eb4, downloadSCOP (1eb4)CATH (1eb4)Pseudomonas putida
1gk2, downloadSCOP (1gk2)CATH (1gk2)Pseudomonas putida
1gk3, downloadSCOP (1gk3)CATH (1gk3)Pseudomonas putida
1gkj, downloadSCOP (1gkj)CATH (1gkj)Pseudomonas putida
1gkm, downloadSCOP (1gkm)CATH (1gkm)Pseudomonas putida
3kdy, downloadSCOP (3kdy)CATH (3kdy)Streptomyces globisporus
3kdz, downloadSCOP (3kdz)CATH (3kdz)Streptomyces globisporus

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
152400-Chlamydomonas reinhardtii-gel filtration666649
189000-Pseudomonas fluorescens-sucrose density gradient centrifugation5997
190000-Rattus norvegicus-sedimentation equilibrium34284
200000-Achromobacter liquidum-gel filtration34287
200000-Comamonas testosteroni--34287
200000-Comamonas testosteroni-sedimentation equilibrium5997
203000-Rattus norvegicus-disc gel electrophoresis34288
204000-toad-sucrose density gradient centrifugation5997
210000-Pseudomonas aeruginosa--34278
210000-Pseudomonas sp.-sedimentation equilibrium34278
210000-Pseudomonas aeruginosa-sucrose density gradient centrifugation5997
210000-Pseudomonas sp.--5997
218000-Pseudomonas fluorescens-sucrose density gradient centrifugation5997
220000-Bacillus subtilis-sucrose density gradient centrifugation34279
220000-Cavia porcellus-gel-permeation chromatography, liver and epidermis enzyme34294
220000-Pseudomonas putida-gel filtration34302
220000-Bacillus subtilis-sucrose density gradient centrifugation5997
226000-Rattus norvegicus-sucrose density gradient centrifugation5997
243000-Homo sapiens-sucrose density gradient centrifugation5997
additional information-Rattus norvegicus--34308

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
?Rattus norvegicus-x * 71800, SDS-PAGE666902
tetramerPseudomonas sp.-4 * 55000, SDS-PAGE34277
tetramerBacillus subtilis-4 * 55675, calculation from sequence of amino acid34297
tetramerStreptomyces griseus-4 * 53000, calculation from sequence of amino acid; 4 * 55000, denaturing PAGE34301
tetramerPseudomonas putida-4 * 53700, calculation from sequence of amino acid34302
tetramerPseudomonas putida-4 * 53559, calculation from sequence of amino acid34309
tetramerPseudomonas putida-homotetramer with D2-symmetry, model building34310
tetramerBacillus subtilis--5997
tetramerComamonas testosteroni-4 * 54000, sedimentation in the presence of 6 M guanidine hypochloride and mercaptoethanol5997
tetramerPseudomonas sp.--34302, 5997
tetramerPseudomonas putida--663816
tetramerChlamydomonas reinhardtii-4 * 38100, SDS-PAGE666649
tetramerBacillus subtilis Marburg 168-4 * 55675, calculation from sequence of amino acid-
tetramerChlamydomonas reinhardtii CCAP 11/32A-4 * 38100, SDS-PAGE-
tetramerPseudomonas putida PRS1-4 * 53700, calculation from sequence of amino acid-
tetramerStreptomyces griseus NRRL B-2682-4 * 53000, calculation from sequence of amino acid; 4 * 55000, denaturing PAGE-

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
additional informationHomo sapiens-autocatalytic intrachain posttranslational cyclization651573
additional informationPseudomonas putida-the peptide at the active center of the enzyme is considered to be posttranslationally dehydrated to form an electrophilic 4-methylidene-imidazole-one group663816

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-Achromobacter liquidum-34287
construction of enzyme structure with a closed active site by modifying the HAL structure including the L-cysteine inhibitor by replacement of the 39-80 loop containing the catalytically essential Tyr53, in every subunit of the homotetrameric enzyme. The most plausible reaction pathway involves the N-3,5-dihydro-5-methylidene-4H-imidazol-4-one intermediate structure in which the L-histidine substrate is covalently bound to the N-3,5-dihydro-5-methylidene-4H-imidazol-4-one prosthetic group of the apoenzyme via the amino group. Zn-complex formation plays a role in the reactivity and substrate specificityPseudomonas putida-715968
crystal structure of C273A/D145A, C273A/F329A and C273A/F329G double mutants at 2.25 A, 2.0 A and 1.9 A resolution, respectively; crystal structure of native histidase inactivated with L-cystein at 1.0 A and Y280F mutant histidase at 1.7 APseudomonas putida-653903
structure solved to 1.8 A resolutionPseudomonas putida-663816
wild-type and mutantPseudomonas putida-34309

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
75-Achromobacter liquidum-15 min, stable for 30 min, without loss of activity34287
80-Bacillus subtilis-15 min, no loss of activity34279

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
rapid decrease of activity in presence of mercaptoethanol or cysteine, 56% of initial activity after 1 d, 20% of initial activity after 2 d. In presence of DTT, the enzyme remains stable for several daysChlamydomonas reinhardtii-666649

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
in the absence of L-cysteine enzyme is completely stable in an atmosphere of N2 and O2Pseudomonas sp.-34285
inactivation of the enzyme by L-cysteine requires presence of O2Pseudomonas sp.-34285

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
5C, crystalline enzyme in 3.5 M ammonium sulfate, stable for 1 yearAchromobacter liquidum-34287
37C, enzyme in solution: 50% loss of activity after 9.5 days, microencapsulated enzyme: 50% loss of activity after 15 daysPseudomonas fluorescens-34299
4C, enzyme in solution: 27% loss of activity after 21 days, and 60% loss of activity after 77 days, microencapsulated enzyme: 5% loss of activity after 21 days, and less than 50% loss of activity after 77 daysPseudomonas fluorescens-34299
-10C, 50% loss of activity after 4 monthsPseudomonas sp.-34291
-20C, 0.05 M potassium phosphate buffer, pH 7.0, no significant loss of activity for 2 yearsPseudomonas sp.-34287
0-4C, in a tube containing a few drops of chloroformPseudomonas sp.-34277
2C, 0.1 M potassium phosphate, pH 7.2, 0.1 mM MnCl2 saturated with chloroform, stable for 9 months without loss of activityPseudomonas sp.-34278
0C, 24 h, pH 3.0 or pH 12.0, complete loss of activityRattus norvegicus-34284
0C, 24 h, pH 7.0-10.0, enzyme retains full activityRattus norvegicus-34284
0C, complete loss of activity within 1 weekRattus norvegicus-34284

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-Achromobacter liquidum-34287
-Chlamydomonas reinhardtii-666649
-Oncorhynchus mykiss-34293
-Pseudomonas putida-679156
recombinant histidasePseudomonas putida-651111, 651437, 651565, 653903
-Pseudomonas sp.-34277, 34278, 34291
-Rattus norvegicus-34284, 34288
native and recombinant enzymeRattus norvegicus-666902
partialRattus norvegicus-34289
-Streptomyces griseus-34303

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-Bacillus subtilis-34297
expression in Escherichia coliPseudomonas putida-34302, 5766, 651111, 651437, 651565, 653903, 716438
into the pT7-7 vector for expression in Escherichia coli BL21DE3 cellsPseudomonas putida-679156
expression in Escherichia coliRattus norvegicus-34308
expression in Escherichia coli as a His-tagged fusion proteinRattus norvegicus-666902

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
A142DPseudomonas putida-3.4% of wild-type activity653903
A142GPseudomonas putida-93% of wild-type activity653903
C273APseudomonas putida-20% of wild-type kcat651111
C273A/D145APseudomonas putida-no activity, crystal structure653903
C273A/E414APseudomonas putida-no activity651111
C273A/E414QPseudomonas putida-0.06% of wild-type kcat651111
C273A/F329APseudomonas putida-0.2% of wild-type kcat651111
C273A/F329APseudomonas putida-0.04% of wild-type activity, crystal structure653903
C273A/F329GPseudomonas putida-no activity, crystal structure653903
C273A/H83LPseudomonas putida-no activity651111
C273A/N195APseudomonas putida-0.02% of wild-type kcat651111
C273A/Q277APseudomonas putida-0.2% of wild-type kcat651111
C273A/R283IPseudomonas putida-0.9% of wild-type kcat651111
C273A/R283KPseudomonas putida-0.01% of wild-type kcat651111
C273A/Y280FPseudomonas putida-0.4% of wild-type kcat651111
C273A/Y53FPseudomonas putida-no activity651111
Cys273APseudomonas putida-mutant yields rectangular crystals34309
Cys273APseudomonas putida--34310
D145APseudomonas putida-no activity653903
F329APseudomonas putida-0.04% of wild-type activity653903
F329GPseudomonas putida-no activity653903
G141APseudomonas putida-1.1% of wild-type activity653903
G144APseudomonas putida-37% of wild-type activity653903
Y280FPseudomonas putida-0.9% of wild-type activity653903

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
crystalline enzyme is prepared with 24% recovery of activityAchromobacter liquidum-34287

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
synthesisPseudomonas fluorescens-enzyme can be successfully microcapsulated within cellulose nitrate artificial cells34299
analysisPseudomonas sp.-a potentiometric sensor is made by immobilizing histidine ammonia-lyase on an ammonia gas-sensing electrode34291

DISEASETITLE OF PUBLICATIONLINK TO PUBMED
AcidosisAdverse effects of halothane in a canine model of acute right ventricular hypertension. PubMed
AcidosisChanges of protein synthesis in liver tissue following ligation of hepatic artery or portal vein in rats. PubMed
AcidosisHalothane diminishes changes in cardiac fiber action potential duration induced by hypocarbia and hypercarbia. PubMed
AdenocarcinomaHepatic artery occlusion and energy charge in rat liver tumour. PubMed
AdenocarcinomaInfluence of hepatic artery occlusion and desferrioxamine on liver-tumour growth. PubMed
AdenomaEarly detection of premalignant conditions in the colon by fluorescence endoscopy using local sensitization with hexaminolevulinate. PubMed
AdenomaHexaminolevulinate-induced fluorescence colonoscopy versus white light endoscopy for diagnosis of neoplastic lesions in the colon. PubMed
AIDS-Related ComplexHuman immunodeficiency virus-related lymphomas: a possible association between tumor proliferation, lack of ploidy anomalies, and immune deficiency. PubMed
AlkalosisHalothane diminishes changes in cardiac fiber action potential duration induced by hypocarbia and hypercarbia. PubMed
Alzheimer DiseaseSimultaneous determination of harmine, harmaline and their metabolites harmol and harmalol in beagle dog plasma by UPLC-ESI-MS/MS and its application to a pharmacokinetic study. PubMed
AneurysmHepatic artery ligation. PubMed
Atrioventricular BlockConscious state comparisons of the effects of the inhalation anesthetics and diltiazem, nifedipine, or verapamil on specialized atrioventricular conduction times in spontaneously beating dog hearts. PubMed
Barrett EsophagusClinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus. PubMed
Bone Diseases, MetabolicThe bone mineral status of patients with Marfan syndrome. PubMed
Carcinogenesis[The alteration of histidase catalytic activity and the expression of the enzyme protein in rat primary hepatomas] PubMed
CarcinomaA role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions. PubMed
CarcinomaCase report: hand-assisted laparoscopic radical heminephrectomy for renal-cell carcinoma in a horseshoe kidney. PubMed
CarcinomaComparison of aminolevulinic acid and hexylester aminolevulinate induced protoporphyrin IX distribution in human bladder cancer. PubMed
CarcinomaConfocal Laser Endomicroscopy of Bladder Tumors Associated With Photodynamic Diagnosis: An Ex Vivo Pilot Study. PubMed
CarcinomaDecrease of epidermal histidase activity by tumor-promoting phorbol esters. PubMed
CarcinomaEarly detection of premalignant conditions in the colon by fluorescence endoscopy using local sensitization with hexaminolevulinate. PubMed
CarcinomaFlexible cystoscopy assisted by hexaminolevulinate induced fluorescence: a new approach for bladder cancer detection and surveillance? PubMed
CarcinomaPhotodynamic diagnosis of ovarian cancer using hexaminolaevulinate: a preclinical study. PubMed
Carcinoma[Pathohistological evaluation of hepatic artery ligation (HAL) or transcatheter arterial embolization (TAE) on primary carcinoma of the liver] PubMed
Carcinoma in SituFlexible cystoscopy assisted by hexaminolevulinate induced fluorescence: a new approach for bladder cancer detection and surveillance? PubMed
Carcinoma, Basal CellA role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions. PubMed
Carcinoma, HepatocellularA lipotrope-dependent increase of histidase and urocanase in the livers of choline-deficient rats and in the Reuber H-35 transplanted hepatoma. PubMed
Carcinoma, HepatocellularEffect of Zajdela ascites hepatoma on the activity and synthesis of liver histidase of tumor-bearing rats. PubMed
Carcinoma, HepatocellularInfluence of hepatic artery occlusion and desferrioxamine on liver-tumour growth. PubMed
Carcinoma, Hepatocellular[The alteration of histidase catalytic activity and the expression of the enzyme protein in rat primary hepatomas] PubMed
Carcinoma, Squamous CellA role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions. PubMed
Carcinoma, Squamous CellDecrease of epidermal histidase activity by tumor-promoting phorbol esters. PubMed
Carcinoma, Transitional CellComparison of aminolevulinic acid and hexylester aminolevulinate induced protoporphyrin IX distribution in human bladder cancer. PubMed
CardiomyopathiesThe effects of isoflurane and halothane on left ventricular afterload in dogs with dilated cardiomyopathy. PubMed
Catalepsy8-OH-DPAT, a 5-HT1A agonist and ritanserin, a 5-HT2A/C antagonist, reverse haloperidol-induced catalepsy in rats independently of striatal dopamine release. PubMed
CatalepsyB vitamins attenuate haloperidol-induced orofacial dyskinesia in rats: possible involvement of antioxidant mechanisms. PubMed
CatalepsyCatalepsy induced by striatal acetylcholinesterase inhibition with fasciculin in rats. PubMed
CatalepsyCombined treatment of ascorbic acid or alpha-tocopherol with dopamine receptor antagonist or nitric oxide synthase inhibitor potentiates cataleptic effect in mice. PubMed
CatalepsyComparison of chronic intermittent haloperidol and raclopride effects on striatal dopamine release and synaptic ultrastructure in rats. PubMed
CatalepsyEffect of haloperidol on cyclic AMP and inositol trisphosphate in rat striatum in vivo. PubMed
CatalepsyEvidence for genetically mediated dysfunction of the central dopaminergic system in the stargazer rat. PubMed
CatalepsyGlucocorticoids attenuate haloperidol-induced catalepsy through adrenal catecholamines. PubMed
CatalepsyParticipation of prostaglandins in the action of kinins on the central dopaminergic system in the rat. I. The action of kinins on the central dopaminergic system after pretreatment with indomethacin. PubMed
CatalepsyPotentiation of haloperidol-induced catalepsy by beta-adrenoceptor antagonists in mice. PubMed
CatalepsySerotonergic involvement in haloperidol-induced catalepsy. PubMed
CatalepsySerotonergic modulation of extrapyramidal motor disorders in mice and rats: Role of striatal 5-HT(3) and 5-HT(6) receptors. PubMed
CatalepsyTolerance to catalepsy following chronic haloperidol is not associated with changes in GABA release in the globus pallidus. PubMed
CholestasisAdministration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated rats. PubMed
Cholestasis[The antioxidant action of dalargin on the liver in experimental acute cholestasis] PubMed
Colorectal NeoplasmsHand-assisted laparoscopy leads to efficient colorectal cancer surgery. PubMed
Coronary StenosisIsoflurane causes more severe regional myocardial dysfunction than halothane in dogs with a critical coronary artery stenosis. PubMed
DehydrationAutocatalytic peptide cyclization during chain folding of histidine ammonia-lyase. PubMed
DeliriumAripiprazole and haloperidol in the treatment of delirium. PubMed
DementiaEffects of smoking and cytochrome P450 2D6*10 allele on the plasma haloperidol concentration/dose ratio. PubMed
Dermatitis, PhototoxicInduction of Apoptosis by Hexaminolevulinate-Mediated Photodynamic Therapy in Human Colon Carcinoma Cell Line 320DM. PubMed
Diabetes Mellitus, Experimental[Histidase and urokinase activity in the blood and liver of the rat in alloxan diabetes and the effect of insulin on their activities] PubMed
Dyskinesia, Drug-InducedDeep brain stimulation of the subthalamic or entopeduncular nucleus attenuates vacuous chewing movements in a rodent model of tardive dyskinesia. PubMed
DyskinesiasAssessment of striatal extracellular dopamine and dopamine metabolites by microdialysis in haloperidol-treated rats exhibiting oral dyskinesia. PubMed
DyskinesiasCarbamazepine reduces dopamine-mediated behavior in chronic neuroleptic-treated and untreated rats: implications for treatment of tardive dyskinesia and hyperdopaminergic states. PubMed
DyskinesiasSCH 23390: D-1 modulation of oral dyskinesias induced in snakes by Xenopus skin mucus. PubMed
Erysipelas[Mechanism of diagnostic significance of histidase release into the blood in lymphedema] PubMed
Heart FailureComparison of cardiac effects of enflurane, isoflurane, and halothane in the dog heart-lung preparation. PubMed
HemiplegiaDevelopment of single leg version of HAL for hemiplegia. PubMed
HemiplegiaVoluntary motion support control of Robot Suit HAL triggered by bioelectrical signal for hemiplegia. PubMed
Hemophilia ADevelopment and preliminary testing of a Paediatric Version of the Haemophilia Activities List (pedhal). PubMed
Hemophilia AThe impairment in daily life of obese haemophiliacs. PubMed
HemorrhoidsA novel therapy for internal hemorrhoids: ligation of the hemorrhoidal artery with a newly devised instrument (Moricorn) in conjunction with a Doppler flowmeter. PubMed
HemorrhoidsDoppler-guided hemorrhoidal artery ligation (DG-HAL): a safe treatment of II-III degree hemorrhoids for all patients. Could it be potentially also good prophylaxis? PubMed
HemorrhoidsDoppler-guided hemorrhoidal artery ligation. PubMed
HepatitisHistidase and urocanase activities of liver and plasma. Correlations between tissue enzyme levels and plasmatic increases during human and mouse viral hepatitis. PubMed
Hepatitis[Diagnostic importance of determination of histidase activity in blood serum of children with viral hepatitis] PubMed
Hepatitis[Effect of carnosine and 4-methyluracil on the development of experimental hepatitis in rats] PubMed
Hepatitis ADETECTION OF HISTIDASE AND UROCANASE IN BLOOD OF PATIENTS WITH INFECTIOUS HEPATITIS. PubMed
Hepatitis A[DETECTION OF HISTIDASE AND UROCANINASE IN THE BLOOD OF PATIENTS WITH INFECTIOUS HEPATITIS.] PubMed
HepatoblastomaRegulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells. PubMed
histidine ammonia-lyase deficiencyA liver urocanase deficiency. PubMed
histidine ammonia-lyase deficiencyHistidase and histidinemia. Clinical and molecular considerations. PubMed
HIV InfectionsHuman immunodeficiency virus-related lymphomas: a possible association between tumor proliferation, lack of ploidy anomalies, and immune deficiency. PubMed
Hypercholesterolemia[Prevalence of hyperalphalipoproteinemia in the general population] PubMed
HyperemiaAdverse effects of halothane in a canine model of acute right ventricular hypertension. PubMed
HypokinesiaSerotonergic modulation of extrapyramidal motor disorders in mice and rats: Role of striatal 5-HT(3) and 5-HT(6) receptors. PubMed
HypotensionCardiorespiratory and minimum alveolar concentration sparing effects of a continuous intravenous infusion of dexmedetomidine in halothane or isoflurane-anaesthetized rats. PubMed
HypotensionIsoflurane causes more severe regional myocardial dysfunction than halothane in dogs with a critical coronary artery stenosis. PubMed
InfectionHow NHS trusts are tackling healthcare-associated infections. PubMed
InfectionPhotodynamic therapy of cervical intraepithelial neoplasia with hexaminolevulinate. PubMed
Insulin ResistanceEffects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy. PubMed
KetosisUse of parenteral medium-chain triglyceride emulsion for maintaining seizure control in a 5-year-old girl with intractable diarrhea. PubMed
Kidney Failure, ChronicCase report: bilateral hand-assisted laparoscopic nephrectomy in a patient with polycystic horseshoe kidney. PubMed
Language DisordersDisturbances in histidine metabolism in children with speech abnormalities. PubMed
LegionellosisClinical features and predictors of mortality in admitted patients with community- and hospital-acquired legionellosis: a Danish historical cohort study. PubMed
LeukemiaReduced Tumor Lysis Syndrome with Low Dose Chemotherapy for Hyperleukocytic Acute Leukemia prior to Induction Therapy. PubMed
Leukemia[Analysis of bone marrow and peripheral blood cytologic features in hyperleukocytic acute leukemia]. PubMed
Leukemia[Bi-phenotypic leukemia and hybrid leukemia] PubMed
Leukemia[Biological characteristics of hyperleukocytic acute leukemia] PubMed
Leukemia[Some difficult problems in the classification of acute leukemia] PubMed
Leukemia[The expression of CD19 in 210 cases of childhood acute leukemia and its significance] PubMed
Leukemia, Biphenotypic, Acute[The expression of CD19 in 210 cases of childhood acute leukemia and its significance] PubMed
Leukemia-Lymphoma, Adult T-CellDetection of human T-lymphotropic virus type-I DNA and mRNA in the lymph nodes; using polymerase chain reaction in situ hybridization (PCR/ISH) and reverse transcription (RT-PCR/ISH). PubMed
Liver DiseasesPhysical activity and functional abilities in adult males with haemophilia: a cross-sectional survey from a single US haemophilia treatment centre. PubMed
Liver NeoplasmsExperimental studies on the treatment of nonresectable liver cancer. PubMed
Liver NeoplasmsSuperselective intra-arterial chemotherapy with mitomycin C in liver and gallbladder cancer. PubMed
LordosisCa2+/calmodulin system: participation in the progesterone-induced facilitation of lordosis behavior in the ovariectomized estrogen-primed rat. PubMed
Lymphedema[Mechanism of diagnostic significance of histidase release into the blood in lymphedema] PubMed
MalariaPharmacokinetics of halofantrine and n-desbutylhalofantrine in patients with falciparum malaria following a multiple dose regimen of halofantrine. PubMed
MalnutritionHepatic histidase gene expression responds to protein rehabilitation in undernourished growing rats. PubMed
MalnutritionHistidine metabolism in experimental protein malnutrition in rats. PubMed
Marfan SyndromeThe bone mineral status of patients with Marfan syndrome. PubMed
Movement DisordersChronic haloperidol effects on oral movements and radial-arm maze performance in rats. PubMed
Movement DisordersCoenzyme Q10 does not prevent oral dyskinesias induced by long-term haloperidol treatment of rats. PubMed
Movement DisordersDeep brain stimulation of the subthalamic or entopeduncular nucleus attenuates vacuous chewing movements in a rodent model of tardive dyskinesia. PubMed
Movement DisordersEarly gene mapping after deep brain stimulation in a rat model of tardive dyskinesia: Comparison with transient local inactivation. PubMed
Movement DisordersInvolvement of CYP3A4 and CYP2D6 in the metabolism of haloperidol. PubMed
Neck PainComparison of neuromuscular injuries to the surgeon during hand-assisted and standard laparoscopic urologic surgery. PubMed
Neoplasm MetastasisInfluence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: Relevance of epithelial-mesenchymal transition. PubMed
Neoplasm MetastasisThe effect of vasopressin and hepatic artery ligation on the blood supply to normal and metastatic liver tissue. PubMed
Neoplasm Metastasis[Two cases of multiple liver metastases from colorectal cancer which responded well to hepatic arterial infusion (HAI) using 5-fluorouracil and l-leucovorin] PubMed
NeoplasmsA phase III, multicenter comparison of hexaminolevulinate fluorescence cystoscopy and white light cystoscopy for the detection of superficial papillary lesions in patients with bladder cancer. PubMed
NeoplasmsA prospective randomised trial of Hexylaminolevulinate (HEXVIX ) photodynamic assisted transurethral resection (TURBT) plus single shot intravesical MitomycinC versus conventional white-light TURBT plus MitomycinC in newly presenting non-muscle invasive bladder cancer (NMIBC). PubMed
NeoplasmsAnalysis of differential PDT effect in rat bladder tumor models according to concentrations of intravesical hexyl-aminolevulinate. PubMed
NeoplasmsCounteraction of underfeeding-induced inhibition of mammary tumor growth in rats by prolactin and estrogen administration. PubMed
NeoplasmsDecrease of epidermal histidase activity by tumor-promoting phorbol esters. PubMed
NeoplasmsDepth Profile of Protoporphyrin IX Fluorescence in an Amelanotic Mouse Melanoma Model. PubMed
NeoplasmsEffect of hepatic artery ligation on the incorporation of 3H-orotic acid into an adenocarcinoma transplanted to rat liver. PubMed
NeoplasmsEffect on liver tumor growth in rats of allopurinol and 5-fluorouracil in combination with hepatic artery ligation. PubMed
NeoplasmsENZYMES OF HISTIDINE METABOLISM IN NORMAL AND TUMOR TISSUES; HISTIDASE AND UROCANASE ACTIVITY. PubMed
NeoplasmsExperimental liver cancer: improved response after hepatic artery ligation and infusion of tumor necrosis factor-alpha and interferon-gamma. PubMed
NeoplasmsExperimental studies on the treatment of nonresectable liver cancer. PubMed
NeoplasmsFlexible cystoscopy assisted by hexaminolevulinate induced fluorescence: a new approach for bladder cancer detection and surveillance? PubMed
NeoplasmsFluorescence-guided transurethral resection of bladder cancer using hexaminolevulinate: analysis of health economic impact in Sweden. PubMed
NeoplasmsFluorescence-guided transurethral resection of bladder tumours reduces bladder tumour recurrence due to less residual tumour tissue in T??a/T1 patients: a randomized two-centre study. PubMed
NeoplasmsHand-assisted laparoscopic colorectal surgery (HALS) at a community hospital: a prospective analysis of 104 consecutive cases. PubMed
NeoplasmsHand-assisted laparoscopic nephrectomy for inflammatory renal conditions. PubMed
NeoplasmsHand-assisted laparoscopic nephrectomy for stage T1 and large stage T2 renal tumors. PubMed
NeoplasmsHand-assisted laparoscopy for large renal specimens: a multi-institutional study. PubMed
NeoplasmsHepatic artery ligation combined with radiotherapy for treatment of nonresectable primary liver carcinoma. PubMed
NeoplasmsHepatic artery ligation. PubMed
NeoplasmsHepatic artery occlusion and energy charge in rat liver tumour. PubMed
NeoplasmsHepatic artery occlusion for liver cancer. PubMed
NeoplasmsHepatic vascular occlusion combined with adriamycin given by the hepatic artery in rats with adenocarcinoma in the liver. PubMed
NeoplasmsHexaminolevulinate-induced fluorescence colonoscopy versus white light endoscopy for diagnosis of neoplastic lesions in the colon. PubMed
NeoplasmsHexyl aminolevulinate fluorescence cystoscopy: new diagnostic tool for photodiagnosis of superficial bladder cancer--a multicenter study. PubMed
NeoplasmsHigh doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis. PubMed
NeoplasmsHormone dependence of mammary tumors induced in rats by intraperitoneal NMU injection. PubMed
NeoplasmsImmunotherapy in liver tumors: III. A new experimental model of metastatic liver tumors from colorectal carcinoma for cytokine therapy. PubMed
NeoplasmsImproved detection and treatment of bladder cancer using hexaminolevulinate imaging: a prospective, phase III multicenter study. PubMed
NeoplasmsInfluence of hepatic arterial blockage on blood perfusion and VEGF, MMP-1 expression of implanted liver cancer in rats. PubMed
NeoplasmsInfluence of hepatic artery occlusion and desferrioxamine on liver-tumour growth. PubMed
NeoplasmsInfluence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: Relevance of epithelial-mesenchymal transition. PubMed
NeoplasmsOctreotide augments the effects of hepatic arterial occlusion in treating a rat liver tumor model. PubMed
NeoplasmsRearterialization of liver tumors after various dearterialization procedures. PubMed
NeoplasmsRegional management of liver metastases. II. PubMed
NeoplasmsRelationship of hormones to inhibition of mammary tumor development by underfeeding during the "critical period" after carcinogen administration. PubMed
NeoplasmsSpecies-dependent induction of peroxisome proliferation by haloxyfop, an aryloxyphenoxy herbicide. PubMed
NeoplasmsThe effect of histidine ammonia-lyase on some murine tumours. PubMed
NeoplasmsThe effect of total body microwave hyperthermia and hepatic artery ligation on liver tumors--an experimental study in rats. PubMed
NeoplasmsThe effect on extrahepatic cancer of hepatic artery ligation: an experimental study in rats with liver tumors. PubMed
NeoplasmsThe influence of hepatic artery ligation and of vasopressin on liver tumour blood flow in rats. PubMed
NeoplasmsTransient increased expression of VEGF and MMP-1 in a rat liver tumor model after hepatic arterial occlusion. PubMed
NeoplasmsTreatment changes and long-term recurrence rates after hexaminolevulinate (HAL) fluorescence cystoscopy: does it really make a difference in patients with non-muscle-invasive bladder cancer (NMIBC)? PubMed
NeoplasmsUnderfeeding-induced suppression of mammary tumors: counteraction by estrogen and haloperidol. PubMed
Neoplasms[Enzymes in benign and malignant tumors of the liver; arginase and histidase.] PubMed
Neoplasms[Multimodality treatment and two-stage resection for unresectable hepatocellular carcinoma--experimental and clinical studies] PubMed
Neoplasms[Pathohistological evaluation of hepatic artery ligation (HAL) or transcatheter arterial embolization (TAE) on primary carcinoma of the liver] PubMed
Neoplasms[Reversal effect of haloperidol on doxorubicin resistance and chloride channel inhibition in erythroleukemic cell K562/Dox] PubMed
Neoplasms[Treatment of irresectable hepatocellular carcinoma with repeated transient dearterialization] PubMed
NephrosisHepatic histidase and muscle branched chain aminotransferase gene expression in experimental nephrosis. PubMed
Nephrotic SyndromeHepatic histidase and muscle branched chain aminotransferase gene expression in experimental nephrosis. PubMed
OsteoporosisHip axis length as an independent risk factor for hip fracture independently of femural bone mineral density in Caucasian elderly Brazilian women. PubMed
Ovarian NeoplasmsPhotodynamic diagnosis of ovarian cancer using hexaminolaevulinate: a preclinical study. PubMed
PainA novel therapy for internal hemorrhoids: ligation of the hemorrhoidal artery with a newly devised instrument (Moricorn) in conjunction with a Doppler flowmeter. PubMed
PainA randomized clinical trial of living donor nephrectomy: a plea for a differentiated appraisal of mini-open muscle splitting incision and hand-assisted laparoscopic donor nephrectomy. PubMed
PainComparison of neuromuscular injuries to the surgeon during hand-assisted and standard laparoscopic urologic surgery. PubMed
PainEuropean evaluation of a new hyaluronic acid filler incorporating lidocaine. PubMed
PainHaloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia. PubMed
PainMonosialoganglioside cotreatment prevents haloperidol treatment-associated loss of cholinergic enzymes in rat brain. PubMed
PainPrevention of haloperidol-induced alterations in brain acetylcholinesterase activity by vitamins B co-administration in a rodent model of tardive dyskinesia. PubMed
Pancreatitis[Changes in the activity of organ-specific liver enzyme histidase in experimental acute pancreatitis] PubMed
Pancreatitis[Experimental study of the hepatoprotective effect of transcranial transcutaneous electrostimulation and the synthetic analog of leu-enkephalin dalargin] PubMed
Parkinsonian DisordersOlanzapine versus placebo and haloperidol: acute phase results of the North American double-blind olanzapine trial. PubMed
Polycystic Kidney, Autosomal DominantA novel approach to bilateral hand-assisted laparoscopic nephrectomy for autosomal dominant polycystic kidney disease. PubMed
Polycystic Kidney, Autosomal DominantCase report: bilateral hand-assisted laparoscopic nephrectomy in a patient with polycystic horseshoe kidney. PubMed
Postpartum HemorrhageHypogastric artery ligation for severe hemorrhage in obstetric patients. PubMed
Precursor Cell Lymphoblastic Leukemia-Lymphoma[Bi-phenotypic leukemia and hybrid leukemia] PubMed
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma[Analysis of immunophenotypes of acute lymphoblastic leukemia by three color flow cytometry.] PubMed
Psoriasis[Psoriatic rheumatism] PubMed
Psychomotor AgitationOlanzapine versus placebo and haloperidol: acute phase results of the North American double-blind olanzapine trial. PubMed
Respiratory InsufficiencyComparison of clinical signs and hemodynamic variables used to monitor rabbits during halothane- and isoflurane-induced anesthesia. PubMed
Rheumatic Diseases[Psoriatic rheumatism] PubMed
SarcomaThe histopathologic and molecular basis for the diagnosis of histiocytic sarcoma and histiocyte-associated lymphoma of mice. PubMed
SeizuresEffects of diazepam or haloperidol on convulsion and behavioral responses induced by bilateral electrical stimulation in the medial prefrontal cortex. PubMed
Skin NeoplasmsPhotodynamic therapy with topical methyl- and hexylaminolevulinate for prophylaxis and treatment of UV-induced SCC in hairless mice. PubMed
StarvationHepatic artery occlusion and energy charge in rat liver tumour. PubMed
StarvationIn vivo regulation of histidine ammonia-lyase activity from Streptomyces griseus. PubMed
StarvationRegulation of histidase synthesis in intergeneric hybrids of enteric bacteria. PubMed
StrokeCardiopulmonary function during 7 h of constant-dose halothane and methoxyflurane. PubMed
StrokeIsoflurane causes more severe regional myocardial dysfunction than halothane in dogs with a critical coronary artery stenosis. PubMed
StrokePilot study of locomotion improvement using hybrid assistive limb in chronic stroke patients. PubMed
StrokeProtective effects of halothane but not isoflurane against global ischaemic injury in the isolated working rat heart. PubMed
Stroke[Blood serum enzymatic spectrum in vascular diseases of the brain] PubMed
TachycardiaMivazerol prevents the tachycardia caused by emergence from halothane anesthesia partly through activation of spinal alpha 2-adrenoceptors. PubMed
TachycardiaThe association between intravenous haloperidol and prolonged QT interval. PubMed
TachypneaInfluence of dopamine and norepinephrine on the central ventilatory response to hypoxia in conscious cats. PubMed
Urinary Bladder Neoplasms5-Aminolevulinic acid derivatives in photomedicine: Characteristics, application and perspectives. PubMed
Urinary Bladder NeoplasmsA phase III, multicenter comparison of hexaminolevulinate fluorescence cystoscopy and white light cystoscopy for the detection of superficial papillary lesions in patients with bladder cancer. PubMed
Urinary Bladder NeoplasmsA prospective randomised trial of Hexylaminolevulinate (HEXVIX ) photodynamic assisted transurethral resection (TURBT) plus single shot intravesical MitomycinC versus conventional white-light TURBT plus MitomycinC in newly presenting non-muscle invasive bladder cancer (NMIBC). PubMed
Urinary Bladder NeoplasmsAnalysis of differential PDT effect in rat bladder tumor models according to concentrations of intravesical hexyl-aminolevulinate. PubMed
Urinary Bladder NeoplasmsComparison of aminolevulinic acid and hexylester aminolevulinate induced protoporphyrin IX distribution in human bladder cancer. PubMed
Urinary Bladder NeoplasmsFlexible cystoscopy assisted by hexaminolevulinate induced fluorescence: a new approach for bladder cancer detection and surveillance? PubMed
Urinary Bladder NeoplasmsFluorescence-guided transurethral resection of bladder cancer using hexaminolevulinate: analysis of health economic impact in Sweden. PubMed
Urinary Bladder NeoplasmsFluorescence-guided transurethral resection of bladder tumours reduces bladder tumour recurrence due to less residual tumour tissue in T??a/T1 patients: a randomized two-centre study. PubMed
Urinary Bladder NeoplasmsHexyl aminolevulinate fluorescence cystoscopy in bladder cancer. PubMed
Urinary Bladder NeoplasmsHexyl aminolevulinate fluorescence cystoscopy: new diagnostic tool for photodiagnosis of superficial bladder cancer--a multicenter study. PubMed
Urinary Bladder NeoplasmsImproved detection and treatment of bladder cancer using hexaminolevulinate imaging: a prospective, phase III multicenter study. PubMed
Urinary Bladder Neoplasms[Initial experience in the diagnosis and treatment of superficial bladder tumors with Hexvix] PubMed
urocanate hydratase deficiencyA liver urocanase deficiency. PubMed
Warm IschemiaDonor nephrectomy: A comparison of techniques and results of open, hand assisted and full laparoscopic nephrectomy. PubMed
Warm IschemiaLaparoscopic versus open live donor nephrectomy: outcomes analysis of 266 consecutive patients. PubMed
Whooping CoughMivazerol prevents the tachycardia caused by emergence from halothane anesthesia partly through activation of spinal alpha 2-adrenoceptors. PubMed
Wound InfectionLaparoscopic-assisted pancreatic necrosectomy: A new surgical option for treatment of severe necrotizing pancreatitis. PubMed

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISM (UNIPROT ACCESSION NO.)LINK TO PUBMEDSOURCE
5766Consevage, M.W.; Porter, R.D.; Phillips, A.T.Cloning and expression in Escherichia coli of histidine utilization genes from Pseudomonas putidaJ. Bacteriol.162138-1461985Pseudomonas putida PubMed
5997Hanson, K.R.; Havir, E.A.The enzymic elimination of ammoniaThe Enzymes, 3rd Ed. (Boyer, P.D., ed.)775-1661972Bacillus subtilis, Comamonas testosteroni, Enterobacter aerogenes, Homo sapiens, Homo sapiens (P09601), Homo sapiens (O60656), Homo sapiens (P16662), Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas fluorescens A.3.12, Pseudomonas sp., Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium, toad-
34274Mehler, A.H.; Tabor, H.Deamination of histidine to form urocanic acid in liverJ. Biol. Chem.201775-7841953Cavia porcellus, Pseudomonas fluorescens PubMed
34276Klee, C.B.Metal activation of histidine ammonia-lyase. Metal ion-sulfhydryl group relationshipJ. Biol. Chem.2471398-14061972Pseudomonas sp. PubMed
34277Klee, C.B.Histidine ammonia-lyase (Pseudomonas)Methods Enzymol.17B69-731971Pseudomonas sp.-
34278Rechler, M.M.; Tabor, H.Histidine ammonia-lyase (Pseudomonas)Methods Enzymol.17B63-691971Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas sp.-
34279Magasanik, B.; Kaminskas, E.; Kimhi, Y.Histidase (histidine ammonia-lyase) (Bacillus subtilis)Methods Enzymol.17B47-501971Bacillus subtilis, Bacillus subtilis W23G, Enterobacter aerogenes, Salmonella enterica subsp. enterica serovar Typhimurium-
34280Hassall, H.Use of L-histidine ammonia-lyase for the determination of L-histidineMethods Enzymol.17B895-8971971Homo sapiens, Pseudomonas putida, Pseudomonas sp.-
34281La Du, B.N.L-Histidine ammonia-lyase (human stratum corneum)Methods Enzymol.17B891-8941971Homo sapiens, Homo sapiens (O00115)-
34282Morris, M.L.; Lee, S.C.; Harper, A.E.Influence of differential induction of histidine catabolic enzymes on histidine degradation in vivoJ. Biol. Chem.2475793-58041972Rattus norvegicus PubMed
34283Hug, D.H.; Hunter, J.K.Effect of temperature on histidine ammonia-lyase from a psychrophile, Pseudomonas putidaJ. Bacteriol.11992-971974Pseudomonas putida, Pseudomonas putida A.3.12, Rattus norvegicus PubMed
34284Okamura, H.; Nishida, T.; Nakagawa, H.L-histidine ammonia-lyase in rat liver. I. Purification and general characteristicsJ. Biochem.75139-1521974Cavia porcellus, Rattus norvegicus PubMed
34285Klee, C.B.Stereospecific irreversible inhibition of histidine ammonia-lyase by L-cysteineBiochemistry134501-45071974Pseudomonas sp. PubMed
34286Klee, C.B.; Kirk, K.L.; Cohen, L.A.; McPhie, P.Histidine ammonia-lyase. The use of 4-fluorohistidine in identification of the rate-determining stepJ. Biol. Chem.2505033-50401975Pseudomonas sp. PubMed
34287Shibatani, T.; Kakimoto, T.; Chibata, I.Crystalline L-histidine ammonia-lyase of Achromobacter liquidum. Crystallization and enzymic propertiesEur. J. Biochem.55263-2691975Achromobacter liquidum, Achromobacter liquidum IAM 1667, Bacillus cereus, Bacillus subtilis, Comamonas testosteroni, Helianthus sp., Mycobacterium avium, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas sp., Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium, Spinacia oleracea, Vibrio cholerae PubMed
34288Brand, L.M.; Harper, A.E.Histidine ammonia-lyase from rat liver. Purification, properties, and inhibition by substrate analoguesBiochemistry151814-18211976Pseudomonas fluorescens, Rattus norvegicus PubMed
34289Brand L.M.; Harper, A.E.DL-alpha-Hydrazinoimidazolylpropionic acid: an irreversible inhibitor of hepatic histidine ammonia-lyase in vivoArch. Biochem. Biophys.177123-1321976Rattus norvegicus PubMed
34290Kamel, M.Y.; Maksoud, S.A.Co-factor requirements and factors affecting L-histidine ammonia-lyase activity in Vicia fabaZ. Pflanzenphysiol.88255-2621978Vicia faba-
34291Walters, R.R.; Johnson, P.A.; Buck, R.P.Histidine ammonia-lyase enzyme electrode for determination of L-histidineAnal. Chem.521684-16901980Pseudomonas sp.-
34292Polkinghorne, M.A.; Hynes, M.J.L-Histidine utilization in Aspergillus nidulansJ. Bacteriol.149931-9401982Emericella nidulans PubMed
34293Allen, R.L.; Clark, N.J.; Phipps, D.A.Histidine ammonia-lyase from kidney of rainbow trout (Salmo gairdnerii Richardson)Biochem. Soc. Trans.113501983Oncorhynchus mykiss, Scombridae-
34294Allen, R.L.; Hopewell, R.; Prottey, C.Histidine ammonia-lyase in guinea-pig liver and epidermisBiochem. Soc. Trans.11349-3501983Cavia porcellus-
34296Fuchs, R.L.; Kane, J.F.In vivo synthesis of histidine by a cloned histidine ammonia-lyase in Escherichia coliJ. Bacteriol.16298-1011985Klebsiella pneumoniae subsp. pneumoniae PubMed
34297Oda, M.; Sugishita, A.; Furukawa, K.Cloning and nucleotide sequences of histidase and regulatory genes in the Bacillus subtilis hut operon and positive regulation of the operonJ. Bacteriol.1703199-32051988Bacillus subtilis, Bacillus subtilis Marburg 168 PubMed
34298Kroening, T.A.; Kendrick, K.E.Cascading regulation of histidase activity in Streptomyces griseusJ. Bacteriol.1711100-11051989Streptomyces griseus PubMed
34299Khanna, R.; Chang, T.M.S.Characterization of L-histidine ammonia-lyase immobilized by microencapsulation in artificial cells: preparation, kinetics, stability, and in vitro depletion of histidineInt. J. Artif. Organs13189-1951990Pseudomonas fluorescens PubMed
34300Burton, D.L.; McGill, W.B.Inductive and repressive effects of carbon and nitrogen on L-histidine ammonia-lyase activity in a black chernozemic soilSoil Biol. Biochem.23939-9461991unidentified-
34301Wu, P.C.; Kroening, T.A.; White, P.J.; Kendrick, K.E.Histidine ammonia-lyase from Streptomyces griseusGene11519-251992Streptomyces griseus, Streptomyces griseus NRRL B-2682 PubMed
34302Hernandez, D.; Phillips, A.T.Purification and Characterization of Pseudomonas putida histidine ammonia-lyase expressed in Escherichia coliProtein Expression Purif.4473-4781993Pseudomonas putida, Pseudomonas putida PRS1, Pseudomonas sp. PubMed
34303White, P.J.; Kendrick, K.E.Inactivation of histidine ammonia-lyase from Streptomyces griseus by dicarbonyl reagentsBiochim. Biophys. Acta1163273-2791993Streptomyces griseus PubMed
34304Ahmed, H.K.; Mitchell, W.J.; Priest, F.G.Catabolite repression of histidase biosynthesis in Bacillus sphaericus by acetateFEMS Microbiol. Lett.10671-751993Bacillus subtilis, Klebsiella pneumoniae subsp. pneumoniae, Lysinibacillus sphaericus, Lysinibacillus sphaericus 2362-
34305Hernandez, D.; Phillips, A.T.; Zon, J.1-amino-2-imidazol-4 -ylethylphosphonic acid is a potent reversible inhibitor of Pseudomonas putida histidine ammonia-lyaseBiochem. Mol. Biol. Int.32189-1941994Pseudomonas putida PubMed
34306Hernandez, D.; Phillips, A.T.Ser-143 is an essential active site residue in histidine ammonia-lyase of Pseudomonas putidaBiochem. Biophys. Res. Commun.2011433-14381994Pseudomonas putida PubMed
34307Weber, K.; Retey, J.On the nature of the irreversible inhibition of histidine ammonia lyase by cysteine and dioxygenBioorg. Med. Chem.41001-10061996Pseudomonas putida PubMed
34308Sano, H.; Tada, T.; Moriyama, A.; Ogawa, H.; Asai, K.; Kawai, Y.; Hodgson, M.E.; Kato, T.; Wada, Y.; Suchi, M.Isolation of a rat histidase cDNA sequence and expression in Escherichia coli--evidence of extrahepatic/epidermal distributionEur. J. Biochem.250212-2211997Mus musculus, Rattus norvegicus PubMed
34309Schwede, T.F.; Baedeker, M.; Langer, M.; Retey, J.; Schulz, G.E.Homogenization and crystallization of histidine ammonia-lyase by exchange of a surface cysteine residueProtein Eng.12151-1531999Pseudomonas putida PubMed
34310Schwede, T.F.; Retey, J.; Schulz, G.E.Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophileBiochemistry385355-53611999Pseudomonas putida, Pseudomonas putida (P21310) PubMed
651111Rother, D.; Poppe, L.; Viergutz, S.; Langer, B.; Retey, J.Characterization of the active site of histidine ammonia-lyase from Pseudomonas putidaEur. J. Biochem.2686011-60192001Pseudomonas putida (P21310), Pseudomonas putida PubMed
651437Merkel, D.; Retey, J.Further insight into the mechanism of the irreversible inhibition of histidine ammonia-lyase by L-cysteine and dioxygenHelv. Chim. Acta831151-11602000Pseudomonas putida-
651565Galpin, J.D.; Ellis, B.E.; Tanner, M.E.The Inactivation of Histidine Ammonia-Lyase by L-Cysteine and Oxygen: Modification of the Electrophilic CenterJ. Am. Chem. Soc.12110840-108411999Pseudomonas putida-
651573Donnelly, M.; Fedeles, F.; Wirstam, M.; Siegbahn, P.E.; Zimmer, M.Computational analysis of the autocatalytic posttranslational cyclization observed in histidine ammonia-lyase. A comparison with green fluorescent proteinJ. Am. Chem. Soc.1234679-46862001Homo sapiens PubMed
653093Ascencio, C.; Tovar, A.R.; Medina-Campos, O.N.; Pedraza-Chaverri, J.; Torres, N.Hepatic histidase and muscle branched chain aminotransferase gene expression in experimental nephrosisLife Sci.672775-27842000Rattus norvegicus PubMed
653903Baedeker, M.; Schulz, G.E.Autocatalytic peptide cyclization during chain folding of histidine ammonia-lyaseStructure1061-672002Pseudomonas putida (P21310) PubMed
663816Asano, Y.; Kato, Y.; Levy, C.; Baker, P.; Rice, D.Structure and Function of Amino Acid Ammonia-lyasesBiocatal. Biotransform.22131-1382004Pseudomonas putida-
665126Kawai, Y.; Moriyama, A.; Asai, K.; Coleman-Campbell, C.M.; Sumi, S.; Morishita, H.; Suchi, M.Molecular characterization of histidinemia: identification of four missense mutations in the histidase geneHum. Genet.116340-3462005Homo sapiens PubMed
666649Hellio, C.; Veron, B.; Le Gal, Y.Amino acid utilization by Chlamydomonas reinhardtii: Specific study of histidinePlant Physiol. Biochem.42257-2642004Chlamydomonas reinhardtii, Chlamydomonas reinhardtii CCAP 11/32A PubMed
666902Ortiz, V.; Torres, N.; Tovar, A.R.Production of recombinant rat hepatic histidaseRev. Invest. Clin.5643-502004Rattus norvegicus-
679156Katona, A.; Tosa, M.I.; Paizs, C.; Retey, J.Inhibition of histidine ammonia lyase by heteroaryl-alanines and acrylatesChem. Biodivers.3502-5082006Pseudomonas putida PubMed
691650Welsh, M.M.; Karagas, M.R.; Applebaum, K.M.; Spencer, S.K.; Perry, A.E.; Nelson, H.H.A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactionsCarcinogenesis291950-19542008Homo sapiens PubMed
693378Eckhart, L.; Schmidt, M.; Mildner, M.; Mlitz, V.; Abtin, A.; Ballaun, C.; Fischer, H.; Mrass, P.; Tschachler, E.Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acidJ. Dermatol. Sci.50209-2152008Homo sapiens PubMed
715968Seff, A.L.; Pilbak, S.; Silaghi-Dumitrescu, I.; Poppe, L.Computational investigation of the histidine ammonia-lyase reaction: a modified loop conformation and the role of the zinc(II) ionJ. Mol. Model.171551-15632011Pseudomonas putida PubMed
716438Reilly, J.T.; Troester, K.A.; Tyner, T.T.; Vitale, D.A.; Risher, T.R.Inhibition of histidine ammonia lyase by 8-methoxypsoralen and psoralen-oxidized photoproductsPhotochem. Photobiol.861272-12772010Pseudomonas putida PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 4.3.1.3)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)