Information on EC 3.6.3.24 - nickel-transporting ATPase:
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The lowest common taxonomy group for this enzyme is: Bacteria

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EC NUMBERCOMMENTARY
3.6.3.24-

RECOMMENDED NAMEGeneOntology No.
nickel-transporting ATPaseGO:0015413

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
ATP + H2O + Ni2+/out = ADP + phosphate + Ni2+/in
show the reaction diagram		----

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
hydrolysis of phosphoric ester----
transmembrane transport----

PATHWAYKEGG LinkMetaCyc Link
No entries in this field

SYSTEMATIC NAMEIUBMB Comments
ATP phosphohydrolase (nickel-importing)ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports Ni2+.

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

CAS REGISTRY NUMBERCOMMENTARY
9000-83-3-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Helicobacter pylori-210290--Manually annotated by BRENDA team
Thermoanaerobacter kivuiATCC 33488210289--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O + Ni2+/outADP + phosphate + Ni2+/in
show the reaction diagram		Helicobacter pylori--210290--?
ATP + H2O + Ni2+/outADP + phosphate + Ni2+/in
show the reaction diagram		Thermoanaerobacter kivui--210289-210289?
ATP + H2O + Ni2+/outADP + phosphate + Ni2+/in
show the reaction diagram		Thermoanaerobacter kivui-the capacity for Ni2+ transport is greatest with cells harvested from the mid-exponential to late-exponential phases of growth210289--?

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
ATP + H2O + Ni2+/outADP + phosphate + Ni2+/in
show the reaction diagram		Thermoanaerobacter kivui-the capacity for Ni2+ transport is greatest with cells harvested from the mid-exponential to late-exponential phases of growth210289--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
No entries in this field

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
No entries in this field

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
Mg2+Thermoanaerobacter kivui--210289 2D-image

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
D-glucoseThermoanaerobacter kivui-stimulates210289 2D-image
H2Thermoanaerobacter kivui-stimulates210289 2D-image

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.0023-Ni2+Thermoanaerobacter kivui--210289 2D-image

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
6.5-Thermoanaerobacter kivui-at 55°C210289

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
4075Thermoanaerobacter kivui-40°C: activity at 40°C is 40% of the activity at 75°C210289

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
No entries in this field

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
No entries in this field

PDBSCOPCATHORGANISM
1zlq, downloadSCOP (1zlq)CATH (1zlq)Escherichia coli (strain K12)
2noo, downloadSCOP (2noo)CATH (2noo)Escherichia coli (strain K12)
3mvw, downloadSCOP (3mvw)CATH (3mvw)Escherichia coli (strain K12)
3mvx, downloadSCOP (3mvx)CATH (3mvx)Escherichia coli (strain K12)
3mvy, downloadSCOP (3mvy)CATH (3mvy)Escherichia coli (strain K12)
3mvz, downloadSCOP (3mvz)CATH (3mvz)Escherichia coli (strain K12)
3mw0, downloadSCOP (3mw0)CATH (3mw0)Escherichia coli (strain K12)
3mz9, downloadSCOP (3mz9)CATH (3mz9)Escherichia coli (strain K12)
3mzb, downloadSCOP (3mzb)CATH (3mzb)Escherichia coli (strain K12)

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
No entries in this field

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISMLINK TO PUBMEDSOURCE
210289Yang, H.; Daniel, S.L.; Hsu, T.; Drake, H.L.Nickel transport by the thermophilic acetogen Acetogenium kivuiAppl. Environ. Microbiol.551078-10811989Thermoanaerobacter kivui PubMed
210290Hendricks, J.K.; Mobley, H.L.T.Helicobacter pylori ABC transporter: effect of allelic exchange mutagenesis on urease activityJ. Bacteriol.1795892-59021997Helicobacter pylori PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 3.6.3.24)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)