Information on EC 3.5.3.12 - agmatine deiminase:
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The expected taxonomic range for this enzyme is: Bacteria

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EC NUMBERCOMMENTARY
3.5.3.12-

RECOMMENDED NAMEGeneOntology No.
agmatine deiminaseGO:0047632

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
agmatine + H2O = N-carbamoylputrescine + NH3
show the reaction diagram		----
agmatine + H2O = N-carbamoylputrescine + NH3
show the reaction diagram		the plant enzyme also catalyzes the reactions of EC 2.1.3.3, ornithine carbamoyltransferase, EC 2.1.3.6, putrescine carbamoyltransferase, and EC 2.7.2.2, carbamate kinase, thus functioning as a putrescine synthase, converting agmatine and ornithine into putrescine and citrulline, respectively, Cys180 and Cys366 are involved in catalysis but are not essential, residues are located in the substrate binding pocketArabidopsis thalianaQ8GWW7655571
agmatine + H2O = N-carbamoylputrescine + NH3
show the reaction diagram		the enzyme does not show activity of EC 2.1.3.3, ornithine carbamoyltransferase, EC 2.1.3.6, putrescine carbamoyltransferase, and EC 2.7.2.2, carbamate kinase, while putrescine synthase is a multifunctional enzyme, overviewCucumis sativus-657259
agmatine + H2O = N-carbamoylputrescine + NH3
show the reaction diagram		like other GME hydrolases the enzyme possesses a high pKa active site Cys, suggesting that the enzyme employs a reverse protonation mechanismHelicobacter pylori, Porphyromonas gingivalis, Streptococcus mutans, Streptococcus mutans 6715, Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans E49, Streptococcus mutans HS6, Streptococcus mutans JC2, Streptococcus mutans K1-R, Streptococcus mutans OMZ 176-718884

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
amidine hydrolysis----
C-N bond cleavageArabidopsis thalianaQ8GWW7-655571
C-N bond cleavageCucumis sativus--657259
hydrolysisStreptococcus mutans 6715, Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans E49, Streptococcus mutans HS6, Streptococcus mutans, Streptococcus mutans JC2, Streptococcus mutans K1-R, Streptococcus mutans OMZ 176-involved in agmatine deiminase system695768
hydrolysis of C-N bond of an amidino groupArabidopsis thalianaQ8GWW7-655571
hydrolysis of C-N bond of an amidino groupCucumis sativus--657259

PATHWAYKEGG LinkMetaCyc Link
Arginine and proline metabolism00330 -
arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway)-ARGDEG-III-PWY
Metabolic pathways01100 -
putrescine biosynthesis II-PWY-43

SYSTEMATIC NAMEIUBMB Comments
agmatine iminohydrolaseThe plant enzyme also catalyses the reactions of EC 2.1.3.3 (ornithine carbamoyltransferase), EC 2.1.3.6 (putrescine carbamoyltransferase) and EC 2.7.2.2 (carbamate kinase), thus functioning as a putrescine synthase, converting agmatine and ornithine into putrescine and citrulline, respectively.

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
AgDHelicobacter pyloriQ9ZN18-711375
AgDIEnterococcus faecalis SD10Q837U5-674316
AgDIBacillus cereus--719620
AgDIEnterococcus faecalis--674316, 719620
AgDILactobacillus hilgardii, Lactobacillus sakei, Lactobacillus sakei 23K, Lactobacillus sakei NRIC 1071T, Pseudomonas aeruginosa--719620
agmatine amidinohydrolase----
agmatine amidinohydrolaseCucumis sativus--657259
agmatine deiminaseArabidopsis thalianaQ8GWW7-655571
agmatine deiminaseCucumis sativus--657259
agmatine deiminaseSelenomonas ruminantiumQ5KR05-685687
agmatine deiminaseStreptococcus criceti, Streptococcus criceti AHT, Streptococcus criceti HS-1, Streptococcus downei, Streptococcus downei 33748--700535
agmatine deiminaseStreptococcus mutans--695768, 700535
agmatine deiminaseStreptococcus oralis, Streptococcus oralis SK10, Streptococcus ratti, Streptococcus ratti ATCC19645, Streptococcus ratti FA-1, Streptococcus salivarius, Streptococcus salivarius HHT, Streptococcus salivarius M36, Streptococcus salivarius PG-202, Streptococcus sanguinis, Streptococcus sanguinis 903, Streptococcus sanguinis DSM20066, Streptococcus sanguinis SK4, Streptococcus sanguinis SK49, Streptococcus sobrinus, Streptococcus sobrinus UAB66--700535
agmatine deiminaseBacillus cereus, Enterococcus faecalis, Lactobacillus hilgardii, Lactobacillus hilgardii 464, Lactobacillus hilgardii CETC4786T, Lactobacillus hilgardii ISE 5211, Lactobacillus hilgardii Microenos HP, Lactobacillus hilgardii X1B, Lactobacillus hilgardii XB--692430, 719620
agmatine deiminaseLactobacillus sakei, Lactobacillus sakei 23K, Lactobacillus sakei NRIC 1071T--719620
agmatine deiminasePseudomonas aeruginosa--692430, 719620
agmatine deiminaseHpAgDHelicobacter pylori--718884
agmatine deiminasesPorphyromonas gingivalis, Streptococcus mutans--718884
agmatine iminohydrolasePseudomonas aeruginosa--669081
agu2APseudomonas aeruginosa PA14Q02J61, Q02J64; 713057
AguAPseudomonas aeruginosa--653166
AguASelenomonas ruminantiumQ5KR05-685687
AguABacillus cereus, Enterococcus faecalis, Lactobacillus hilgardii, Lactobacillus sakei 23K, Lactobacillus sakei, Lactobacillus sakei NRIC 1071T, Pseudomonas aeruginosa-gene name719620
aguA proteinPseudomonas aeruginosa--669081
aguA2Lactobacillus hilgardii-gene name719620
PgAgDPorphyromonas gingivalis--718884
putrescine synthaseCucumis sativus--209403
putrescine synthaseLathyrus sativus, Lathyrus sativus P-24--209399, 209403
SmAgDStreptococcus mutans--718884
AIHArabidopsis thalianaQ8GWW7-655571
additional informationArabidopsis thalianaQ8GWW7enzyme belongs to the family of C-N-hydrolases655571

CAS REGISTRY NUMBERCOMMENTARY
37289-17-1-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Arabidopsis thalianagene At5g08170655571Q8GWW7GenBankManually annotated by BRENDA team
Arabidopsis thalianagene T22D6669081Q8GWW7GenBankManually annotated by BRENDA team
Arachis hypogaea-209398, 209402--Manually annotated by BRENDA team
Arachis hypogaeagroundnut, L. cv Punjab-1209397--Manually annotated by BRENDA team
Avena sativaoat, L. var. Black Supreme209396--Manually annotated by BRENDA team
Bacillus cereus-719620--Manually annotated by BRENDA team
Bacillus cereusstrain CECT 148692430--Manually annotated by BRENDA team
Bacillus cereus CECT 148strain CECT 148692430--Manually annotated by BRENDA team
Bacteria-712057--Manually annotated by BRENDA team
Brassica oleraceabrussels sprouts, var. gemmifera Zenker; cabbage, L. var. capitata L.209396--Manually annotated by BRENDA team
Campylobacter jejunigene Cj0949c669081Q0P9V0SwissProtManually annotated by BRENDA team
Caulobacter vibrioidesgene CC0211669081Q9ABL6SwissProtManually annotated by BRENDA team
Chlorella virusPBCV-1, gene A638R669081Q89413SwissProtManually annotated by BRENDA team
Cucumis sativuscucumber209403--Manually annotated by BRENDA team
Cucumis sativuscv. Tokiwajibae657259--Manually annotated by BRENDA team
Deinococcus radioduransgene DR2359669081--Manually annotated by BRENDA team
Enterococcus faecalis-719620--Manually annotated by BRENDA team
Enterococcus faecalisATCC 11700209400--Manually annotated by BRENDA team
Enterococcus faecalisstrain ATCC11700692430--Manually annotated by BRENDA team
Enterococcus faecalisstrain SD10674316Q837U5SwissProtManually annotated by BRENDA team
Enterococcus faecalis ATCC 11700-719620--Manually annotated by BRENDA team
Enterococcus faecalis ATCC11700strain ATCC11700692430--Manually annotated by BRENDA team
Enterococcus faecalis SD10strain SD10674316Q837U5SwissProtManually annotated by BRENDA team
Escherichia coli-209397--Manually annotated by BRENDA team
Evernia prunastriphycobiont/mycobiont, enzyme localized in the mycobiont, growing on Quercus pyrenaica209401--Manually annotated by BRENDA team
Glycine max-209401, 209404--Manually annotated by BRENDA team
Glycine maxsoybean, L.209395--Manually annotated by BRENDA team
Helianthus annuus-209397, 209398, 209402--Manually annotated by BRENDA team
Helianthus annuussunflower, L. var. Sutton's giant yellow209396--Manually annotated by BRENDA team
Helicobacter pylori-711375Q9ZN18UniProtManually annotated by BRENDA team
Helicobacter pylori-718884--Manually annotated by BRENDA team
Helicobacter pylorigene HP0049669081--Manually annotated by BRENDA team
Hordeum vulgare-209401, 209402--Manually annotated by BRENDA team
Hordeum vulgarebarley, L. var. zephyr209396--Manually annotated by BRENDA team
Lactobacillus hilgardii-719620--Manually annotated by BRENDA team
Lactobacillus hilgardiistrain X1B692430--Manually annotated by BRENDA team
Lactobacillus hilgardiistrain XB687349--Manually annotated by BRENDA team
Lactobacillus hilgardii X1B-719620--Manually annotated by BRENDA team
Lactobacillus hilgardii X1Bstrain X1B692430--Manually annotated by BRENDA team
Lactobacillus hilgardii XBstrain XB687349--Manually annotated by BRENDA team
Lactobacillus sakeiLactobacillus sakei 23K is unable to produce putrescine since no putrescine carbamoyltransferase can be amplified719620--Manually annotated by BRENDA team
Lactococcus lactisgene YrfC669081Q9CEY6SwissProtManually annotated by BRENDA team
Lathyrus sativus-209399, 209401, 209403--Manually annotated by BRENDA team
Nicotiana tabacum-209402--Manually annotated by BRENDA team
no activity in Malus sylvestrisapple, Mill. var. Lord lambourne209396--Manually annotated by BRENDA team
no activity in Pisum sativumpea, L. var. Meteor209396--Manually annotated by BRENDA team
no activity in Secale cerealerye, L.209396--Manually annotated by BRENDA team
no activity in Streptococcus gordonii-700535--Manually annotated by BRENDA team
no activity in Streptococcus sanguinisgenospecies 1700535--Manually annotated by BRENDA team
no activity in Triticum aestivumwheat, var. Atle209396--Manually annotated by BRENDA team
Oryza sativa-209404--Manually annotated by BRENDA team
Oryza sativarice209402--Manually annotated by BRENDA team
Porphyromonas gingivalis-718884--Manually annotated by BRENDA team
Pseudomonas aeruginosaPAO1719620--Manually annotated by BRENDA team
Pseudomonas aeruginosastrain PAO1653166, 669081, 692430--Manually annotated by BRENDA team
Pseudomonas aeruginosastrain PAO1, CECT 4122692430Q9I6J9UniProtManually annotated by BRENDA team
Pseudomonas aeruginosa PA14isoform agu2A713057Q02J61UniProtManually annotated by BRENDA team
Pseudomonas aeruginosa PA14isoform agu2A'713057Q02J64UniProtManually annotated by BRENDA team
Rhodococcus sp.C-x209405--Manually annotated by BRENDA team
Rhodococcus sp. C-xC-x209405--Manually annotated by BRENDA team
Selenomonas ruminantium-685687Q5KR05UniProtManually annotated by BRENDA team
Soja hispida-209401--Manually annotated by BRENDA team
Streptococcus cricetistrain AHT700535--Manually annotated by BRENDA team
Streptococcus criceti AHTstrain AHT700535--Manually annotated by BRENDA team
Streptococcus downeistrain 33748700535--Manually annotated by BRENDA team
Streptococcus downei 33748strain 33748700535--Manually annotated by BRENDA team
Streptococcus mutans-712291, 718884--Manually annotated by BRENDA team
Streptococcus mutansstrain UA159669131--Manually annotated by BRENDA team
Streptococcus mutansstrain UA159 and strain GS-5700535--Manually annotated by BRENDA team
Streptococcus mutansstrain UA159, strain WTZ as construt of lacZ695768--Manually annotated by BRENDA team
Streptococcus oralis-700535--Manually annotated by BRENDA team
Streptococcus rattistrain FA-1 and strain BHT700535--Manually annotated by BRENDA team
Streptococcus salivarius-700535--Manually annotated by BRENDA team
Streptococcus sanguinisgenospecies 2700535--Manually annotated by BRENDA team
Streptococcus sobrinusstrain 6715700535--Manually annotated by BRENDA team
Streptomyces coelicolorgene SCC2.08669081O86509SwissProtManually annotated by BRENDA team
Xylella fastidiosagene XF2442669081Q9PAQ3SwissProtManually annotated by BRENDA team
Zea mays-209396, 209397, 209401, 209402, 209404, 670510--Manually annotated by BRENDA team
Zea mayscorn, L. variety Hy2x07209395--Manually annotated by BRENDA team
Zea maysL. cv Goldencross Bantam T51209398--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
physiological functionPseudomonas aeruginosa PA14Q02J61, Q02J64deletion of the agmatine operon agu2ABCA' reduces biofilm production of strain PA14 following addition of exogenous agmatine; deletion of the agmatine operon agu2ABCA', specifically its secreted product Agu2A', reduces biofilm production of strain PA14 following addition of exogenous agmatine713057

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
Ac-SGRGK + H2O? + NH3
show the reaction diagram		Helicobacter pyloriQ9ZN18-711375--?
agmatine + ADP + phosphateATP + putrescine + NH3 + CO2
show the reaction diagram		Cucumis sativus--209403-209403?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Escherichia coli--209397--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Hordeum vulgare--209396, 209401, 209402--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Zea mays--209395, 209396, 209397, 209398, 209401, 209402, 209404, 670510--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Nicotiana tabacum--209402--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Glycine max--209395-209395?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Glycine max--209401, 209404--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Avena sativa--209396--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Lathyrus sativus--209399, 209401, 209403--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Arachis hypogaea--209397, 209398, 209402--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Enterococcus faecalis--209400--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Helicobacter pylori--718884--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Cucumis sativus--209403, 657259--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Rhodococcus sp.--209405--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Brassica oleracea, Helianthus annuus--209396--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Helianthus annuus--209397, 209398, 209402--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Oryza sativa--209402, 209404--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Soja hispida, Evernia prunastri--209401--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Porphyromonas gingivalis, Streptococcus mutans--718884--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Lactobacillus hilgardii--687349--ir
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Pseudomonas aeruginosaQ9I6J9-692430--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Pseudomonas aeruginosa PA14Q02J61, Q02J64-713057--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Helicobacter pyloriQ9ZN18-711375major products. Ammonia and N-carbamoylputrescine are produced in approximately equimolar amounts-?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Arabidopsis thalianaQ8GWW7highly specific for655571--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Lathyrus sativus-multifunctional enzyme, acts also as putrescine transcarbamylase, putrescine synthase, ornithine transcarbamylase and carbamate kinase209399, 209403--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Cucumis sativus-multifunctional enzyme, acts also as putrescine transcarbamylase, putrescine synthase, ornithine transcarbamylase and carbamate kinase209403--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Rhodococcus sp.-multifunctional enzyme, acts also as putrescine transcarbamylase, putrescine synthase, ornithine transcarbamylase and carbamate kinase209405--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Streptococcus mutans-agmatine deiminase system (AgDS)669131--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Pseudomonas aeruginosa-aguBA operon induced by a promoter in the aguR-aguB intergenic region669081--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Pseudomonas aeruginosa-sole substrate for AguA653166--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Enterococcus faecalisQ837U5highly specific for agmatine674316--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Pseudomonas aeruginosaQ9I6J9Pseudomonas aeruginosa is an organism with high putrescine production activity compared to other microorganisms, overview692430--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Streptococcus mutans-assay at pH 5.5 or pH 7.0695768--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Lactobacillus hilgardii ISE 5211, Lactobacillus hilgardii Microenos HP--687349--ir
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Enterococcus faecalis SD10Q837U5highly specific for agmatine674316--?
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Lactobacillus hilgardii X1B, Lactobacillus hilgardii CETC4786T, Lactobacillus hilgardii XB, Lactobacillus hilgardii 464--687349--ir
agmatine + H2ONH3 + N-carbamoylputrescine
show the reaction diagram		Streptococcus sanguinis, Streptococcus ratti, Streptococcus mutans, Streptococcus salivarius, Streptococcus oralis, Streptococcus sobrinus, Streptococcus criceti, Streptococcus downei-assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid700535--?
agmatine + H2ONH3 + N-carbamoylputrescine
show the reaction diagram		Pseudomonas aeruginosaQ9I6J9assay at pH 6.5, 28°C, 8 h692430--ir
agmatine + H2ONH3 + N-carbamoylputrescine
show the reaction diagram		Enterococcus faecalis, Bacillus cereus, Lactobacillus hilgardii-assay at pH 6.5, 28°C, 8 h692430--ir
agmatine + H2ONH3 + N-carbamoylputrescine
show the reaction diagram		Streptococcus ratti ATCC19645-assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid700535--?
agmatine + H2ONH3 + N-carbamoylputrescine
show the reaction diagram		Lactobacillus hilgardii ISE 5211-assay at pH 6.5, 28°C, 8 h692430--ir
agmatine + H2ONH3 + N-carbamoylputrescine
show the reaction diagram		Streptococcus criceti AHT-assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid700535--?
agmatine + H2ONH3 + N-carbamoylputrescine
show the reaction diagram		Lactobacillus hilgardii Microenos HP-assay at pH 6.5, 28°C, 8 h692430--ir
agmatine + H2ONH3 + N-carbamoylputrescine
show the reaction diagram		Streptococcus criceti HS-1, Streptococcus downei 33748, Streptococcus ratti FA-1-assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid700535--?
agmatine + H2ONH3 + N-carbamoylputrescine
show the reaction diagram		Lactobacillus hilgardii X1B, Lactobacillus hilgardii CETC4786T, Lactobacillus hilgardii XB, Lactobacillus hilgardii 464-assay at pH 6.5, 28°C, 8 h692430--ir
agmatine + H2Oputrescine + ?
show the reaction diagram		Selenomonas ruminantiumQ5KR0525 mM, assay at pH 6.5, 10 min, 40°C685687--?
agmatine + ornithine + H2O + phosphateputrescine + citrulline + NH3 + phosphate
show the reaction diagram		Lathyrus sativus--209399-209399?
agmatine + ornithine + H2O + phosphateputrescine + citrulline + NH3 + phosphate
show the reaction diagram		Lathyrus sativus, Cucumis sativus--209403-209403?
carbamoyl phosphate + ADP + H2OATP + CO2 + NH3
show the reaction diagram		Lathyrus sativus--209399-209399r
carbamoyl phosphate + ornithinecitrulline + phosphate
show the reaction diagram		Lathyrus sativus--209399-209399r
guanidine + H2O? + NH3
show the reaction diagram		Helicobacter pyloriQ9ZN18-711375--?
N-alpha-benzoyl-L-arginine amide + H2O? + NH3
show the reaction diagram		Helicobacter pyloriQ9ZN18-711375--?
N-alpha-benzoyl-L-arginine ethyl ester + H2O? + NH3
show the reaction diagram		Helicobacter pyloriQ9ZN18-711375--?
N-alpha-benzoyl-L-arginine methyl ester + H2O? + NH3
show the reaction diagram		Helicobacter pyloriQ9ZN18-711375--?
N-carbamoylputrescine + phosphateputrescine + carbamoyl phosphate
show the reaction diagram		Lathyrus sativus--209399-209399r
streptomycin + H2O? + NH3
show the reaction diagram		Helicobacter pyloriQ9ZN18-711375--?
L-arginine + H2O? + NH3
show the reaction diagram		Helicobacter pyloriQ9ZN18-711375--?
additional information?-Zea mays, Glycine max-arginine, creatine and citrulline are no substrates209404---
additional information?-Arabidopsis thalianaQ8GWW7substrate specificity, no activity with guanidinoacetic acid, beta-guanidinopropionic acid, gamma-guanidinobutyric acid, L-arginine, L-citrulline, L-glutamine, L-ornithine, N-carbamoyl-beta-alanine, N-carbamoyl-D,L-aspartic acid, putrescine, spermidine, allylcyanide, beta-cyano-L-alanine, indole-3-acetonitrile, 3-phenylpropionitrile655571---
additional information?-Pseudomonas aeruginosa-no activity with arginine, creatine, creatinine, guanidinoacetate, 3-guanidinopropionate and 4-guanidinobutytrate as substrates653166---
additional information?-Enterococcus faecalis, Enterococcus faecalis SD10Q837U5does not use L-arginine, L-argininamide, or arcaine (1,4-diguanidinobutane) as substrates674316---

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Escherichia coli--209397--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Hordeum vulgare--209396, 209401, 209402--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Zea mays--209395, 209396, 209397, 209398, 209401, 209402, 209404--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Nicotiana tabacum--209402--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Glycine max--209395-209395
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Glycine max--209401, 209404--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Avena sativa--209396--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Lathyrus sativus--209399, 209401, 209403--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Arachis hypogaea--209397, 209398, 209402--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Enterococcus faecalis--209400--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Cucumis sativus--209403--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Rhodococcus sp.--209405--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Brassica oleracea, Helianthus annuus--209396--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Helianthus annuus--209397, 209398, 209402--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Oryza sativa--209402, 209404--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Soja hispida, Evernia prunastri--209401--
agmatine + H2ON-carbamoylputrescine + NH3
show the reaction diagram		Pseudomonas aeruginosaQ9I6J9Pseudomonas aeruginosa is an organism with high putrescine production activity compared to other microorganisms, overview692430--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
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METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
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INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
2-chloroacetamidineHelicobacter pylori, Porphyromonas gingivalis, Streptococcus mutans--718884 2D-image
8-AzaguanineEvernia prunastri--209401 2D-image
agmatineEvernia prunastri-above 8 mM slight substrate inhibition209401 2D-image
agmatineStreptococcus mutans-AgDS-deficient strain is unable to grow in the presence of 20 mM agmatine, suggesting that AgDS converts a growth-inhibitory substance into products that can enhance acid tolerance669131 2D-image
Al3+Selenomonas ruminantiumQ5KR051 mM685687 2D-image
arcaineCucumis sativus-agmatine analogue, strong competitive inhibition657259 2D-image
arcaineZea mays-competitive inhibitor670510 2D-image
arcaineEnterococcus faecalis, Enterococcus faecalis SD10Q837U5competitive inhibitor674316 2D-image
arginineBacillus cereus-highest inhibitory effect with 10 g/l arginine, up to 80% less putrescine production692430 2D-image
arginineEnterococcus faecalis-highest inhibitory effect with 10 g/l arginine, up to 83% less putrescine production692430 2D-image
arginineLactobacillus hilgardii-highest inhibitory effect with 10 g/l arginine, up to 75% less putrescine production692430 2D-image
argininePseudomonas aeruginosaQ9I6J9highest inhibitory effect with 10 g/l arginine, up to 68% less putrescine production692430 2D-image
Ba2+Oryza sativa--209402 2D-image
Ca2+Oryza sativa--209402 2D-image
Ca2+Zea mays--209398, 209402 2D-image
cadaverineArachis hypogaea-competitive inhibition209397 2D-image
cadaverineArachis hypogaea--209398, 209402 2D-image
carbohydrateStreptococcus mutans--700535-
cationic mercuryPseudomonas aeruginosa-enzyme 90% inhibited at 0.1 mM653166 2D-image
Co2+Zea mays-1 mM 55% inhibition209398 2D-image
Co2+Glycine max, Zea mays--209404 2D-image
Co2+Selenomonas ruminantiumQ5KR051 mM685687 2D-image
Co2+Helicobacter pyloriQ9ZN18-711375 2D-image
Cu2+Arachis hypogaea--209397, 209398 2D-image
Cu2+Zea mays-1 mM 100% inhibition209398 2D-image
Cu2+Glycine max--209404 2D-image
Cu2+Zea mays--209397, 209404 2D-image
Cu2+Selenomonas ruminantiumQ5KR051 mM685687 2D-image
CycloheximideEvernia prunastri--209401 2D-image
Fe2+Zea mays--209398 2D-image
Fe2+Selenomonas ruminantiumQ5KR051 mM685687 2D-image
Fe3+Arachis hypogaea--209397 2D-image
Fe3+Selenomonas ruminantiumQ5KR051 mM685687 2D-image
fructoseBacillus cereus-at concentration of 0.1 g/l about 18% less putrescine production, at concentration of 1 g/l about 60% less putrescine production692430 2D-image
fructoseEnterococcus faecalis-at concentration of 0.1 g/l about 5% less putrescine production, at concentration of 1 g/l about 30% less putrescine production692430 2D-image
fructoseLactobacillus hilgardii-at concentration of 0.1 g/l about 5% less putrescine production, at concentration of 1 g/l about 75% less putrescine production692430 2D-image
fructosePseudomonas aeruginosaQ9I6J9at concentration of 0.1 g/l about 60% less putrescine production, at concentration of 1 g/l 70% less putrescine production692430 2D-image
glucoseBacillus cereus-at concentration of 0.1 g/l about 22% less putrescine production, at concentration of 1 g/l about 70% less putrescine production692430 2D-image
glucoseEnterococcus faecalis-at concentration of 0.1 g/l about 8% less putrescine production, at concentration of 1 g/l about 70% less putrescine production692430 2D-image
glucoseLactobacillus hilgardii-at concentration of 0.1 g/l about 16% less putrescine production, at concentration of 1 g/l about 73% less putrescine production692430 2D-image
glucosePseudomonas aeruginosaQ9I6J9at concentration of 0.1 g/l about 10% less putrescine production, at concentration of 1 g/l 19% less putrescine production692430 2D-image
Hg2+Arachis hypogaea--209397 2D-image
Hg2+Selenomonas ruminantiumQ5KR05strong inhibitor685687 2D-image
iodoacetamideGlycine max, Zea mays--209404 2D-image
iodoacetamideArabidopsis thalianaQ8GWW7about 70% inhibition at 2 mM, wild-type enzyme655571 2D-image
iodoacetamideSelenomonas ruminantiumQ5KR05strong inhibitor685687 2D-image
iodoacetamideHelicobacter pylori, Porphyromonas gingivalis, Streptococcus mutans--718884 2D-image
iodoacetoamidePseudomonas aeruginosa-enzyme 95% inhibited at 0.1 mM653166 2D-image
L-arginineEvernia prunastri-high concentration209401 2D-image
Mg2+Oryza sativa--209402 2D-image
Mg2+Zea mays--209398, 209402 2D-image
Mn2+Oryza sativa--209402 2D-image
N,N'-diguanidinobutaneZea mays-arcain, potential analogue of agmatine, 1 mM 50% inhibition209396 2D-image
N,N'-diguanidinobutaneZea mays--209398 2D-image
N-(4-aminobutyl)-2-chloro-ethanimidamideHelicobacter pyloriQ9ZN18i.e. ABCA , haloacetamidine-containing agmatine analogue711375-
N-(4-aminobutyl)-2-chloroethanimidamideHelicobacter pylori, Porphyromonas gingivalis, Streptococcus mutans--718884-
N-(4-aminobutyl)-2-fluoro-ethanimidamideHelicobacter pyloriQ9ZN18i.e. ABFA, haloacetamidine-containing agmatine analogue711375-
N-(4-aminobutyl)-2-fluoroethanimidamideHelicobacter pylori, Porphyromonas gingivalis, Streptococcus mutans-inactivation proceeds via a multistep mechanism that requires general acid catalysis718884-
N-ethylmaleimideGlycine max, Zea mays--209404 2D-image
NaCNZea mays--209396 2D-image
NEMArabidopsis thalianaQ8GWW71 mM655571 2D-image
Ni2+Zea mays--209398 2D-image
Ni2+Selenomonas ruminantiumQ5KR051 mM685687 2D-image
Ni2+Helicobacter pyloriQ9ZN18-711375 2D-image
p-chloromercuribenzoateArachis hypogaea--209397, 209398 2D-image
p-chloromercuribenzoateGlycine max--209404 2D-image
p-chloromercuribenzoateZea mays--209396, 209397, 209398, 209404 2D-image
p-chloromercuribenzoatePseudomonas aeruginosa-enzyme 12% inhibited at 0.1 mM653166 2D-image
putrescineArachis hypogaea--209397, 209398, 209402 2D-image
SemicarbazideEvernia prunastri--209401 2D-image
SemicarbazideZea mays--209396, 209401 2D-image
spermidineArachis hypogaea-competitive inhibition209397 2D-image
spermidineArachis hypogaea--209398, 209402 2D-image
spermidineOryza sativa--209402, 209404 2D-image
spermidineBacillus cereus-at concentration of 0.1 g/l about 10% less putrescine production, at concentration of 1 g/l about 20% less putrescine production692430 2D-image
spermidineEnterococcus faecalis-at concentration of 0.1 g/l about 18% less putrescine production, at concentration of 1 g/l about 25% less putrescine production692430 2D-image
spermidineLactobacillus hilgardii-at concentration of 0.1 g/l about 5% less putrescine production, at concentration of 1 g/l about 23% less putrescine production692430 2D-image
spermineArachis hypogaea-10 mM, 50% inhibition209397 2D-image
spermineArachis hypogaea--209398, 209402 2D-image
spermineOryza sativa--209402, 209404 2D-image
spermineBacillus cereus-at concentration of 0.1 g/l about 10% less putrescine production, at concentration of 1 g/l about 20% less putrescine production692430 2D-image
spermineEnterococcus faecalis-at concentration of 0.1 g/l about 5% less putrescine production, at concentration of 1 g/l about 25% less putrescine production692430 2D-image
spermineLactobacillus hilgardii-at concentration of 0.1 g/l about 20% less putrescine production, at concentration of 1 g/l about 25% less putrescine production692430 2D-image
succinateLactobacillus hilgardii-at concentration of 0.1 g/l and 1 g/l only about 2% less putrescine production692430 2D-image
tryptamineArachis hypogaea-2.5 mM, 50% inhibition209397 2D-image
tryptamineArachis hypogaea--209398, 209402 2D-image
tyramineLactobacillus hilgardii-at concentration of 0.1 g/l about 2% less putrescine production692430 2D-image
Zn2+Arachis hypogaea--209397, 209398 2D-image
Zn2+Zea mays-1 mM 85% inhibition209398 2D-image
Zn2+Glycine max--209404 2D-image
Zn2+Zea mays--209397, 209404 2D-image
Zn2+Selenomonas ruminantiumQ5KR051 mM685687 2D-image
Zn2+Helicobacter pyloriQ9ZN18-711375 2D-image

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
agmatineStreptococcus criceti, Streptococcus criceti AHT, Streptococcus criceti HS-1, Streptococcus downei, Streptococcus downei 33748, Streptococcus mutans, Streptococcus mutans 6715, Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans E49, Streptococcus mutans HS6, Streptococcus mutans JC2, Streptococcus mutans K1-R, Streptococcus mutans OMZ 176, Streptococcus ratti, Streptococcus ratti ATCC19645, Streptococcus ratti FA-1, Streptococcus sobrinus, Streptococcus sobrinus UAB66--700535 2D-image
histamineLactobacillus hilgardii-at concentration of 0.1 g/l about 2% more putrescine production, at concentration of 1 g/l about 5% more putrescine production692430 2D-image
histaminePseudomonas aeruginosaQ9I6J9at concentration of 0.1 g/l and 1.0 g/l about 10% more putrescine production692430 2D-image
spermidinePseudomonas aeruginosaQ9I6J9at concentration of 0.1 g/l about 10% more putrescine production, at concentration of 1 g/l 32% more putrescine production692430 2D-image
sperminePseudomonas aeruginosaQ9I6J9at concentration of 0.1 g/l about 2% more putrescine production, at concentration of 1 g/l 23% more putrescine production692430 2D-image
succinateBacillus cereus-at concentration of 1 g/l about 5% more putrescine production692430 2D-image
succinatePseudomonas aeruginosaQ9I6J9at concentration of 0.1 g/l about 15% more putrescine production, at concentration of 1 g/l about 35% more putrescine production692430 2D-image
tartaric acidLactobacillus hilgardii-shows a stimulatory effect on activity687349 2D-image
tyramineLactobacillus hilgardii-at concentration of 1 g/l about 2% more putrescine production692430 2D-image
tyraminePseudomonas aeruginosaQ9I6J9at concentration of 0.1 g/l about 15% more putrescine production, at concentration of 1 g/l 20% more putrescine production692430 2D-image
UreaEvernia prunastri--209401 2D-image
L-lactic acidLactobacillus hilgardii-shows a stimulatory effect on activity687349 2D-image
additional informationLactobacillus hilgardii, Lactobacillus hilgardii 464, Lactobacillus hilgardii CETC4786T, Lactobacillus hilgardii ISE 5211, Lactobacillus hilgardii Microenos HP, Lactobacillus hilgardii X1B, Lactobacillus hilgardii XB-ornithine, D-lactic acid, citric acid, L-malic acid, and DL-malic acid do not modify activity687349-
additional informationPseudomonas aeruginosaQ9I6J9diverse polyamines and sugars increased putrescine production, e.g. succinic acid increases putrescine production, but does not alter agmatine deimination, overview692430-
additional informationStreptococcus mutans, Streptococcus mutans 6715, Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans E49, Streptococcus mutans HS6, Streptococcus mutans JC2, Streptococcus mutans K1-R, Streptococcus mutans OMZ 176-2fold higher expression of aguB in presence of 10 mM agmatine, 2fold higher activity at pH 5.5695768-

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.012-agmatineZea mays--670510 2D-image
0.016-agmatineCucumis sativus-pH 7.0, 30°C657259 2D-image
0.033-agmatineHelicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C711375 2D-image
0.17-agmatineHelicobacter pyloriQ9ZN18mutant D198A, pH 8.0, 37°C711375 2D-image
0.19-agmatineZea mays--209398, 209404 2D-image
0.6-agmatinePseudomonas aeruginosa--653166 2D-image
0.76-agmatineArachis hypogaea--209397, 209398 2D-image
0.8-agmatineEvernia prunastri--209401 2D-image
2.5-agmatineGlycine max--209404 2D-image
6.67-agmatineSelenomonas ruminantiumQ5KR05-685687 2D-image
15-agmatineOryza sativa--209402, 209404 2D-image

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.0047-agmatineHelicobacter pyloriQ9ZN18mutant D198A, pH 8.0, 37°C711375 2D-image
0.082-agmatineHelicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C711375 2D-image
8-agmatinePseudomonas aeruginosa--653166 2D-image

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.0000038-Ac-SGRGKHelicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C7113750
0.0000235-Ac-SGRGKHelicobacter pyloriQ9ZN18mutant D198A, pH 8.0, 37°C7113750
0.0283-agmatineHelicobacter pyloriQ9ZN18mutant D198A, pH 8.0, 37°C7113756544
0.136-agmatinePseudomonas aeruginosa PA14Q02J61, Q02J64pH 9.0, 25°C7130576544
2.45-agmatineHelicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C7113756544
2.624-agmatinePseudomonas aeruginosa PA14Q02J61, Q02J64pH 9.0, 37°C7130576544
0.0000678-guanidineHelicobacter pyloriQ9ZN18mutant D198A, pH 8.0, 37°C71137511192
0.0000812-guanidineHelicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C71137511192
0.000017-L-arginineHelicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C71137512093
0.000149-L-arginineHelicobacter pyloriQ9ZN18mutant D198A, pH 8.0, 37°C71137512093
0.000072-N-alpha-benzoyl-L-arginine amideHelicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C7113750
0.0001285-N-alpha-benzoyl-L-arginine amideHelicobacter pyloriQ9ZN18mutant D198A, pH 8.0, 37°C7113750
0.0000847-N-alpha-benzoyl-L-arginine ethyl esterHelicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C71137522200
0.0001383-N-alpha-benzoyl-L-arginine ethyl esterHelicobacter pyloriQ9ZN18mutant D198A, pH 8.0, 37°C71137522200
0.0001038-N-alpha-benzoyl-L-arginine methyl esterHelicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C71137522202
0.0002183-N-alpha-benzoyl-L-arginine methyl esterHelicobacter pyloriQ9ZN18mutant D198A, pH 8.0, 37°C71137522202
0.000033-streptomycinHelicobacter pyloriQ9ZN18mutant D198A, pH 8.0, 37°C71137516731
0.0000377-streptomycinHelicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C71137516731

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.0033-arcaineZea mays--670510 2D-image
0.0071-arcaineCucumis sativus-pH 7.0, 30°C657259 2D-image
0.028-arcaineEnterococcus faecalis, Enterococcus faecalis SD10Q837U5at 37°C674316 2D-image
10-spermineArachis hypogaea--209397 2D-image
2.5-tryptamineArachis hypogaea--209397 2D-image

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.013-Co2+Helicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C711375 2D-image
0.00087-N-(4-aminobutyl)-2-chloro-ethanimidamideHelicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C711375-
0.00026-N-(4-aminobutyl)-2-chloroethanimidamideStreptococcus mutans, Streptococcus mutans 6715, Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans E49, Streptococcus mutans HS6, Streptococcus mutans JC2, Streptococcus mutans K1-R, Streptococcus mutans OMZ 176-pH 8.0, 37°C718884-
0.00087-N-(4-aminobutyl)-2-chloroethanimidamideHelicobacter pylori-pH 8.0, 37°C718884-
0.015-N-(4-aminobutyl)-2-chloroethanimidamidePorphyromonas gingivalis-pH 8.0, 37°C718884-
0.0068-N-(4-aminobutyl)-2-fluoro-ethanimidamideHelicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C711375-
0.00027-N-(4-aminobutyl)-2-fluoroethanimidamideStreptococcus mutans, Streptococcus mutans 6715, Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans E49, Streptococcus mutans HS6, Streptococcus mutans JC2, Streptococcus mutans K1-R, Streptococcus mutans OMZ 176-pH 8.0, 37°C718884-
0.0068-N-(4-aminobutyl)-2-fluoroethanimidamideHelicobacter pylori-pH 8.0, 37°C718884-
0.091-N-(4-aminobutyl)-2-fluoroethanimidamidePorphyromonas gingivalis-pH 8.0, 37°C718884-
0.1-Ni2+Helicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C711375 2D-image
0.03-Zn2+Helicobacter pyloriQ9ZN18wild-type, pH 8.0, 37°C711375 2D-image

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
0.0002-Streptococcus ratti-strain FA-1, 25 mM glucose, without agmatine700535
0.004-Streptococcus ratti-strain FA-1, 25 mM galactose, without agmatine700535
0.006-Streptococcus downei, Streptococcus downei 33748-25 mM glucose + 10 mM agmatine700535
0.0097-Streptococcus sobrinus-25 mM sorbitol + 10 mM agmatine700535
0.01-Zea mays-crude extract of enzyme670510
0.01055-Pseudomonas aeruginosa PA14Q02J61, Q02J64pH 9.0, 25°C713057
0.0109-Streptococcus criceti, Streptococcus criceti AHT, Streptococcus criceti HS-1-25 mM sorbitol + 10 mM agmatine700535
0.015-Zea mays-enzyme activity of shoots grown for 7 days at 25°C in the dark and light respectively670510
0.015-Pseudomonas aeruginosa PA14Q02J61, Q02J64pH 9.0, 37°C713057
0.016-Streptococcus sobrinus-25 mM glucose + 10 mM agmatine700535
0.02-Streptococcus ratti-strain FA-1, 250 mM glucose, without agmatine700535
0.03-Streptococcus ratti-strain FA-1, 250 mM glucose + 10 mM agmatine700535
0.032-Streptococcus ratti-strain FA-1, 25 mM glucose + 10 mM agmatine700535
0.034-Streptococcus ratti ATCC19645, Streptococcus ratti FA-1, Streptococcus ratti-strain FA-1, 25 mM galactose + 10 mM agmatine700535
0.04-Streptococcus ratti ATCC19645, Streptococcus ratti FA-1, Streptococcus ratti-strain FA-1, 250 mM galactose, without agmatine700535
0.052-Streptococcus ratti-strain BHT, 25 mM glucose + 10 mM agmatine700535
0.058-Streptococcus mutans-strain UA159, 25 mM glucose + 10 mM agmatine700535
0.058-Streptococcus ratti ATCC19645, Streptococcus ratti FA-1, Streptococcus ratti-strain FA-1, 250 mM galactose + 10 mM agmatine700535
0.078-Streptococcus mutans-strain GS-5, 25 mM galactose + 10 mM agmatine700535
0.102-Streptococcus ratti-strain FA-1, 25 mM glucose + 10 mM agmatine700535
0.135-Arachis hypogaea--209397
0.17-Streptococcus mutans 6715, Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans E49, Streptococcus mutans HS6, Streptococcus mutans JC2, Streptococcus mutans K1-R, Streptococcus mutans OMZ 176, Streptococcus mutans-strain UA159, 25 mM sorbitol + 10 mM agmatine700535
0.4762-Streptococcus mutans-strain UA159, 25 mM galactose + 10 mM agmatine700535
1.1-Lathyrus sativus, Lathyrus sativus P-24--209399
2.64-Cucumis sativus--209403
5.9-Enterococcus faecalis-cells in stationary phase of growth209400
14.5-Cucumis sativus-purified enzyme657259
16.7-Enterococcus faecalis--209400
26.4-Arabidopsis thalianaQ8GWW7purified recombinant wild-type enzyme655571
32.2-Zea mays-purified enzyme670510
47.31-Oryza sativa--209402
172.2-Glycine max--209404
205.5-Evernia prunastri--209401
876.3-Zea mays--209398
additional information-Pseudomonas aeruginosaQ9I6J9-692430

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
4.5-Lactobacillus hilgardii--687349
5.58.5Arachis hypogaea--209397
5.5-Streptococcus mutans-2fold higher actitity compared with enzyme activity at pH 7.0695768
6-Oryza sativa--209402, 209404
6-Streptococcus criceti, Streptococcus downei, Streptococcus mutans, Streptococcus oralis, Streptococcus ratti, Streptococcus salivarius, Streptococcus sobrinus-assay at700535
6.57.5Zea mays--209396, 209397
6.5-Zea mays--209398
6.5-Glycine max, Zea mays--209404
6.5-Zea mays--670510
6.5-Selenomonas ruminantiumQ5KR05assay at685687
6.5-Bacillus cereus, Enterococcus faecalis, Lactobacillus hilgardii-assay at692430
6.5-Pseudomonas aeruginosaQ9I6J9assay at; in vivo assay at692430
6.5-Bacillus cereus, Enterococcus faecalis, Lactobacillus hilgardii, Lactobacillus sakei, Pseudomonas aeruginosa-assay at719620
7-Arabidopsis thalianaQ8GWW7-655571
7-Cucumis sativus--657259
7.5-Glycine max--209395
7.5-Lathyrus sativus-putrescine transcarbamylase and carbamate kinase function209399
8-Lathyrus sativus-ornithine transcarbamylase function209399
8-Pseudomonas aeruginosa-in Tris-HCl buffer653166
8-Helicobacter pylori, Porphyromonas gingivalis, Streptococcus mutans-assay at718884
8.8-Lathyrus sativus-agmatine iminohydrolase function209399
additional information-Streptococcus sanguinis-assay at pH 6.0, 30 min, reaction stopped by 10% trichloroacetic acid700535

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
4.510.5Zea mays--209396
57Streptococcus mutans-AgD induction clearly enhanced at low pH values, aguA ca. 3.7fold higher in cells grown at pH 5 than that grown at pH 7, stress response pathway of this organism669131
59Glycine max--209395
67Zea mays-activity rapidly declining below pH 6.0 and declining less rapidly above pH 7.0209398
6-Zea mays-purified enzyme shows 85% of maximum activity670510
6.58Cucumis sativus-89% of maximal activity at pH 6.5, 91% of maximal activity at pH 8.0657259
8-Zea mays-purified enzyme shows 85% of maximum activity670510

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
28-Oryza sativa--209402, 209404
28-Bacillus cereus, Enterococcus faecalis, Lactobacillus hilgardii 464, Lactobacillus hilgardii, Lactobacillus hilgardii CETC4786T, Lactobacillus hilgardii ISE 5211, Lactobacillus hilgardii Microenos HP, Lactobacillus hilgardii X1B, Lactobacillus hilgardii XB-assay at692430
28-Pseudomonas aeruginosaQ9I6J9assay at; in vivo assay at692430
28-Bacillus cereus, Enterococcus faecalis, Lactobacillus hilgardii 464, Lactobacillus hilgardii, Lactobacillus hilgardii CETC4786T, Lactobacillus hilgardii ISE 5211, Lactobacillus hilgardii Microenos HP, Lactobacillus hilgardii X1B, Lactobacillus hilgardii XB, Lactobacillus sakei 23K, Lactobacillus sakei, Lactobacillus sakei NRIC 1071T, Pseudomonas aeruginosa-assay at719620
30-Cucumis sativus-assay at657259
3540Arabidopsis thalianaQ8GWW7-655571
37-Lactobacillus hilgardii, Lactobacillus hilgardii 464, Lactobacillus hilgardii CETC4786T, Lactobacillus hilgardii ISE 5211, Lactobacillus hilgardii Microenos HP, Lactobacillus hilgardii X1B, Lactobacillus hilgardii XB--687349
37-Helicobacter pylori, Porphyromonas gingivalis, Streptococcus mutans 6715, Streptococcus mutans AHT, Streptococcus mutans, Streptococcus mutans BHT, Streptococcus mutans E49, Streptococcus mutans HS6, Streptococcus mutans JC2, Streptococcus mutans K1-R, Streptococcus mutans OMZ 176-assay at718884
40-Selenomonas ruminantiumQ5KR05assay at685687
45-Pseudomonas aeruginosa--653166
50-Glycine max--209404
60-Zea mays--209398, 209404

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
3740Streptococcus mutans 6715, Streptococcus mutans, Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans E49, Streptococcus mutans HS6, Streptococcus mutans JC2, Streptococcus mutans K1-R, Streptococcus mutans OMZ 176-AgD activity 4fold higher in Streptococcus mutans grown at 42°C than at 37°C, stress response pathway of this organism669131

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
axisGlycine max--209404Manually annotated by BRENDA team
cotyledonArachis hypogaea--209397, 209398, 209402Manually annotated by BRENDA team
cotyledonCucumis sativus--209403Manually annotated by BRENDA team
embryoOryza sativa--209402Manually annotated by BRENDA team
leafBrassica oleracea--209396Manually annotated by BRENDA team
leafArachis hypogaea--209397, 209402Manually annotated by BRENDA team
leafZea mays--209396, 209397, 209402Manually annotated by BRENDA team
seedZea mays--209397Manually annotated by BRENDA team
seedlingAvena sativa--209396Manually annotated by BRENDA team
seedlingLathyrus sativus P-24--209399Manually annotated by BRENDA team
seedlingHelianthus annuus--209396, 209397, 209398, 209402Manually annotated by BRENDA team
seedlingLathyrus sativus--209399, 209403Manually annotated by BRENDA team
seedlingGlycine max--209404Manually annotated by BRENDA team
seedlingOryza sativa--209402, 209404Manually annotated by BRENDA team
seedlingZea mays--209396, 209397, 209398, 209402, 209404Manually annotated by BRENDA team
seedlingCucumis sativus--209403, 657259Manually annotated by BRENDA team
shootZea mays--209398, 670510Manually annotated by BRENDA team
thallusEvernia prunastri--209401Manually annotated by BRENDA team

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
cytosolGlycine max--5829209404Manually annotated by BRENDA team
cytosolZea mays--5829209398, 209404Manually annotated by BRENDA team
periplasmPseudomonas aeruginosa PA14Q02J61, Q02J64isoform Agu2A' contains a twin-arginine translocation signal at its N-terminus and is secreted to the periplasm-713057Manually annotated by BRENDA team

PDBSCOPCATHORGANISM
1vkp, downloadSCOP (1vkp)CATH (1vkp)Arabidopsis thaliana
2q3u, downloadSCOP (2q3u)CATH (2q3u)Arabidopsis thaliana
3h7c, downloadSCOP (3h7c)CATH (3h7c)Arabidopsis thaliana
3h7k, downloadSCOP (3h7k)CATH (3h7k)Arabidopsis thaliana
2jer, downloadSCOP (2jer)CATH (2jer)Enterococcus faecalis (strain ATCC 700802 / V583)
2ewo, downloadSCOP (2ewo)CATH (2ewo)Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
41190-Pseudomonas aeruginosa-calculated from sequence data669081
45000-Selenomonas ruminantiumQ5KR05gel filtration; SDS-PAGE685687
46000-Enterococcus faecalis SD10Q837U5SDS-PAGE674316
46000-Enterococcus faecalisQ837U5SDS-PAGE674316
55000-Lathyrus sativus, Lathyrus sativus P-24-gel filtration, PAGE209399
56000-Lathyrus sativus, Lathyrus sativus P-24-gel filtration, Sephadex G-200209399
67000-Cucumis sativus-gel filtration657259
70000-Glycine max-gel filtration209404
75000-Zea mays-gel filtration670510
81000-Arabidopsis thalianaQ8GWW7recombinant His-tagged wild-type enzyme, gel filtration655571
82000-Enterococcus faecalis-gel filtration209400
85000-Zea mays-gel filtration209398
85000-Zea mays--209404
85000-Pseudomonas aeruginosa-cross linkage653166
89000-Pseudomonas aeruginosa-gel filtration653166
150000-Cucumis sativus-gel filtration209403
183000-Oryza sativa-gel filtration209402
183000-Oryza sativa--209404

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
?Pseudomonas aeruginosa PA14Q02J61, Q02J64x * 39900, calculated for mature protein713057
dimerZea mays-2 * 43000, SDS-PAGE209398
dimerOryza sativa-2 * 95000, SDS-PAGE209402
dimerOryza sativa--209404
dimerZea mays--209402, 209404
dimerArabidopsis thalianaQ8GWW72 * 43000, recombinant His-tagged wild-type enzyme, SDS-PAGE655571
heterodimerZea mays-1 * 43500 + 1 * 44000, SDS-PAGE670510
homodimerPseudomonas aeruginosa-2 * 43000, SDS-PAGE653166
monomerLathyrus sativus, Lathyrus sativus P-24-1 * 55000, single polypeptide chain, SDS-PAGE209399
monomerGlycine max-1 * 70000, SDS-PAGE209404
oligomerCucumis sativus-1 * 66000 + 1 * 48000 + 1 * 44000 + 1 * 15000, SDS-PAGE209403
tetramerEnterococcus faecalis SD10Q837U5X-ray crystallography and gel filtration674316
tetramerEnterococcus faecalisQ837U5X-ray crystallography and gel filtration674316
monomerSelenomonas ruminantiumQ5KR05-685687
additional informationCucumis sativus-x * 36000, deglycosylated enzyme, SDS-PAGE, x * 47000, glycosylated enzyme, SDS-PAGE, monomer or dimer657259

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
glycoproteinCucumis sativus-N-glycosylation657259
proteolytic modificationPseudomonas aeruginosa PA14Q02J61, Q02J64cleavage of translocation signal713057

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
hanging drop vapour diffusion method with in 50 mM Tris-HCl, pH 7.45, 1 mM dithiothreitol and 20 mM NaClEnterococcus faecalis, Enterococcus faecalis SD10Q837U5674316
to 2.1 A resolution. Residue D198 is the key residue for agmatine recognitionHelicobacter pyloriQ9ZN18711375

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
2.56Lactobacillus hilgardii-agmatine is degraded in a very limited extent when the pH values are close to 2.5, a diminution of activity is observed at pH values above 6.0, at pH values from 3.2 to 3.8, the amount of putrescine formed is 53% and 75% respectively of the maximum amount formed at pH 4.5687349
69Selenomonas ruminantiumQ5KR0530 min, temperature below 40°C685687

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
4-Zea mays-purified enzyme stable for two months670510
33-Brassica oleracea-50% loss of activity after heating for 15 min209396
40-Selenomonas ruminantiumQ5KR05below 40°C stable for 30 min, pH 6.0-9.0685687
40-Lactobacillus hilgardii 464, Lactobacillus hilgardii, Lactobacillus hilgardii CETC4786T, Lactobacillus hilgardii ISE 5211, Lactobacillus hilgardii Microenos HP, Lactobacillus hilgardii X1B, Lactobacillus hilgardii XB-above 40°C a noticeable diminution of activity is observed687349
43-Zea mays-activity reduced by 50% on heating for 15 min209396
50-Zea mays-exposure for 10 min, decrease of 50% in the activity209398
55-Arachis hypogaea-retains 44% activity when exposed for 10 min, completely inactivated at 60°C under the same conditions209397

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
highly unstableCucumis sativus-209403
highly unstable even in presence of glycerol, dithiothreitol and Mg2+, freeze-thawing and dialysis lead to considerable loss of activityLathyrus sativus, Lathyrus sativus P-24-209399

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
4°C, purified enzyme, 2 months, stableCucumis sativus-657259
4°C, purified enzyme lost 30% of the activity in 3 daysGlycine max-209404
4°C purified enzyme lost all component activities within 48 hLathyrus sativus, Lathyrus sativus P-24-209399
-20°C purified enzyme lost 40% activity within 15 daysOryza sativa, Oryza sativa IAC 165, Oryza sativa Japonica, Oryza sativa L. Hitomebore, Oryza sativa M-101, Oryza sativa Nipponbare, Oryza sativa njavara-209402
4°C, purified enzyme lost 30% of the activity in 3 daysZea mays-209398, 209404

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
recombinant His-tagged wild-type and mutant enzymes from Escherichia coli by Ni2+-chelate affinity chromatographyArabidopsis thalianaQ8GWW7655571
-Arachis hypogaea-209397, 209398
-Cucumis sativus-209403
2470foldCucumis sativus-657259
HisTrap Ni-affinity column chromatography and Superdex 200 HR gel filtrationEnterococcus faecalis, Enterococcus faecalis SD10Q837U5674316
-Evernia prunastri-209401
-Glycine max-209404
the protein is recombinantly expressed, lysed by sonication, and then purified by a combination of anion exchange, heparin affinity, and gel filtrationHelicobacter pylori-718884
-Lathyrus sativus, Lathyrus sativus P-24-209399, 209403
-Oryza sativa-209402, 209404
the protein is recombinantly expressed, lysed by sonication, and then purified by a combination of anion exchange, heparin affinity, and gel filtrationPorphyromonas gingivalis-718884
strain PAO4495, 21fold purified to near homogeneity, gel filtrationPseudomonas aeruginosa-653166
-Selenomonas ruminantiumQ5KR05685687
the protein is recombinantly expressed, lysed by sonication, and then purified by a combination of anion exchange, heparin affinity, and gel filtrationStreptococcus mutans-718884
-Zea mays-209398, 209402, 209404
enzyme purified from shoots grown in the dark by DE52 column chromatography, Sephadex G-100 column chromatography and agmatine-epoxy-Sepharose 6B column chromatographyZea mays-670510

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
DNA and amino acid sequence determination and analysis, expression as C-terminally His-tagged wild-type and mutant enzymes in Escherichia coliArabidopsis thalianaQ8GWW7655571
expressed in Escherichia coli BL21 (DE3) cellsEnterococcus faecalis, Enterococcus faecalis SD10Q837U5674316
expression in Escherichia coliHelicobacter pyloriQ9ZN18711375
-Pseudomonas aeruginosa-653166
expression of wild type PAO1 in Escherichia coli XL1-BluePseudomonas aeruginosa-669081
expression in Escherichia coliPseudomonas aeruginosa PA14Q02J61, Q02J64713057
expression in Escherichia coli strain DE3Selenomonas ruminantiumQ5KR05685687
expression in Escherichia coli DH10BStreptococcus mutans-669131

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
presence of an alternate agmatine operon in the Pseudomonas aeruginosa strain PA14 named agu2ABCA' that contains two genes for agmatine deiminases, agu2A and agu2A'. This operon is present in 25% of clinical Pseudomonas aeruginosa isolates. Agmatine induces expression of the operon during the stationary phase of growth and during biofilm growth and agu2ABCA' provides only weak complementation of aguBA, which is induced during log phasePseudomonas aeruginosa PA14Q02J61, Q02J64713057
presence of an alternate agmatine operon in the Pseudomonas aeruginosa strain PA14 named agu2ABCA that contains two genes for agmatine deiminases, agu2A and agu2A'. This operon is present in 25% of clinical Pseudomonas aeruginosa isolates. Agmatine induces expression of the operon during the stationary phase of growth and during biofilm growth and agu2ABCA' provides only weak complementation of aguBA, which is induced during log phasePseudomonas aeruginosa PA14Q02J61, Q02J64713057
induction of the agmatine deiminase system requires agmatine and is optimal at low pH. The VicRK, ComDE, and CiaRH two-component systems influence agmatine deiminase system gene expression in response to acidic and thermal stressesStreptococcus mutans, Streptococcus mutans 6715, Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans E49, Streptococcus mutans HS6, Streptococcus mutans JC2, Streptococcus mutans K1-R, Streptococcus mutans OMZ 176-712291

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
C180AArabidopsis thalianaQ8GWW7site-directed mutagenesis, conserved catalytically relevant Cys, 35% of wild-type activity, inhibition with iodoacetamide is easier abolished by substrate agmatine655571
C364GPseudomonas aeruginosa PA14Q02J61, Q02J64complete loss of activity713057
R3G/R4SPseudomonas aeruginosa PA14Q02J61, Q02J64mutation of the twin-arginine translocation tat-sequence at the N-terminus. Mutant is hardly secreted to periplasm713057
C361ASelenomonas ruminantiumQ5KR0520% enzyme activity of wild-type enzyme685687
C366AArabidopsis thalianaQ8GWW7site-directed mutagenesis, conserved catalytically relevant Cys, 15% of wild-type activity, inhibition with iodoacetamide is easier abolished by substrate agmatine655571
additional informationPseudomonas aeruginosa-mutant strain PAO4541653166
additional informationPseudomonas aeruginosa-strain PAO5001, a knockout mutation of Gene PAO0292669081

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
analysisBacteria-development of a multiplex PCR method for the simultaneous detection of four genes involved in the production of histamine, i.e. histidine decarboxylase hdc, tyramine, i.e.tyrosine decarboxylase tyrdc, and putrescine, via either ornithine decarboxylase odc, or agmatine deiminase agdi. A collection of 810 lactic acid bacteria strains isolated from wine and cider was screened. The most frequent gene corresponds to the agdi gene detected in 112 strains, 14% of all lactic acid bacteria strains, of 10 different lactic acid bacteria species712057
food industryBacteria-development of a multiplex PCR method for the simultaneous detection of four genes involved in the production of histamine, i.e. histidine decarboxylase hdc, tyramine, i.e.tyrosine decarboxylase tyrdc, and putrescine, via either ornithine decarboxylase odc, or agmatine deiminase agdi. A collection of 810 lactic acid bacteria strains isolated from wine and cider was screened. The most frequent gene corresponds to the agdi gene detected in 112 strains, 14% of all lactic acid bacteria strains, of 10 different lactic acid bacteria species712057
medicineRhodococcus sp.-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp.-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. 19070-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. 19070-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. 400-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. 400-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. 7-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. 7-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. A81-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. A81-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. AA21-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. AA21-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. AIU Z-35-1-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. AIU Z-35-1-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. AJ270-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. AJ270-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. AK32-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. AK32-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. AN-22-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. AN-22-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. ATCC39484-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. ATCC39484-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. B1-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. B1-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. C-x-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. C-x-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. C1-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. C1-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. C9-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. C9-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. DK17-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. DK17-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. DX-35-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. DX-35-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. ECU0066-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. ECU0066-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. F2-7-3-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. F2-7-3-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. Fp2-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. Fp2-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. G-74-2-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. G-74-2-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. GK1-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. GK1-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. H1-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. H1-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. HR199-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. HR199-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. IGT8-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. IGT8-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. IGTS8-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. IGTS8-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. IOC-77-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. IOC-77-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. J1-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. J1-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. M-750-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. M-750-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. M-777-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. M-777-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. M4-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. M4-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. N-774-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. N-774-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. N186/21-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. N186/21-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. N595-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. N595-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. N771-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. N771-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. NCIMB 11215-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. NCIMB 11215-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. NCIMB 11216-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. NCIMB 11216-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. NCIMB 12038-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. NCIMB 12038-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. NCIMB 9784-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. NCIMB 9784-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. NCIMB12038-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. NCIMB12038-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. NDB 1165-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. NDB 1165-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. Novo SP361-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. Novo SP361-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. P1-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. P1-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. R04-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. R04-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. R312-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. R312-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. RHA1-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. RHA1-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. S13-4-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. S13-4-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. SHZ-1-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. SHZ-1-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineRhodococcus sp. TK6-developing of an analytic method for agmatine, being an important reagent for medical research209405
nutritionRhodococcus sp. TK6-developing of an analytic method for agmatine, being an important reagent for food research209405
medicineStreptococcus criceti, Streptococcus criceti AHT, Streptococcus criceti HS-1, Streptococcus downei, Streptococcus downei 33748, Streptococcus mutans, Streptococcus ratti, Streptococcus ratti ATCC19645, Streptococcus ratti FA-1, Streptococcus sobrinus, Streptococcus sobrinus UAB66-remove of dental plaque biofilms700535

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISM (UNIPROT ACCESSION NO.)LINK TO PUBMEDSOURCE
209395Le Rudulier, D.; Goas, G.Biogenese de la N-carbamylputrescine et de la putrescine dans les plantules de Glycine max (L.) MerrPhysiol. Veg.18609-6161980Glycine max, Zea mays-
209396Smith, T.A.Agmatine iminohydrolase in maizePhytochemistry82111-21171969Avena sativa, Brassica oleracea, Helianthus annuus, Hordeum vulgare, no activity in Malus sylvestris, no activity in Pisum sativum, no activity in Secale cereale, no activity in Triticum aestivum, Zea mays-
209397Sindhu, R.K.; Desai, H.V.Purification and properties of agmatine iminohydrolase from groundnut cotyledonsPhytochemistry181937-19381979Arachis hypogaea, Escherichia coli, Helianthus annuus, Zea mays-
209398Yanagisawa, H.; Suzuki, Y.Corn agmatine iminohydrolase. Purification and propertiesPlant Physiol.67697-7001981Arachis hypogaea, Helianthus annuus, Zea mays PubMed
209399Srivenugopal, K.S.; Adiga, P.R.Enzymic conversion of agmatine to putrescine in Lathyrus sativus seedlings. Purification and properties of a multifunctional enzyme (putrescine synthase)J. Biol. Chem.2569532-95411981Lathyrus sativus PubMed
209400Simon, J.P.; Stalon, V.Enzymes of agmatine degradation and the control of their synthesis in Streptococcus faecalisJ. Bacteriol.11676-6811982Enterococcus faecalis-
209401Legaz, M.E.; Iglesias, A.; Vicente, C.Regulation of agmatine iminohydrolase of Evernia prunastri by L-arginine metabolitesZ. Pflanzenphysiol.11053-591983Evernia prunastri, Glycine max, Hordeum vulgare, Lathyrus sativus, Soja hispida, Zea mays-
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LINKS TO OTHER DATABASES (specific for EC-Number 3.5.3.12)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)