Information on EC 3.4.23.3 -

Information on EC 3.4.23.3 - gastricsin:

Please wait a moment until all data are loaded. This message will disappear when all data are loaded.

EC NUMBER	COMMENTARY
3.4.23.3	-

RECOMMENDED NAME	GeneOntology No.
gastricsin	-

REACTION	REACTION DIAGRAM	COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
more restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin		-	-	-	-
more restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin		acid endopeptidase	Homo sapiens, Sus scrofa	-	668809

REACTION TYPE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
hydrolysis of peptide bond	-	-	endopeptidase	-

PATHWAY	KEGG Link	MetaCyc Link
No entries in this field

SYSTEMATIC NAME	IUBMB Comments
No entries in this field

SYNONYMS	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
parapepsin II	Sus scrofa	-	-	668809
pepsin C	-	-	-	-
pepsin C	Homo sapiens	-	-	667343, 668809, 709708
pepsin C	Macaca fuscata, Sus scrofa, Xenopus laevis	-	-	668809
pepsin C	Rattus norvegicus	-	-	709708
pepsin II	Homo sapiens	-	-	668809
pepsinogen C	Homo sapiens	P20142	-	718005
PGC	Homo sapiens	P20142	-	718005
pig parapepsin II	-	-	-	-
progastricsin	Homo sapiens	P20142	-	718005
seminal pepsin	Homo sapiens	-	-	668809
EC 3.4.4.22	-	-	formerly	-
additional information	Homo sapiens, Macaca fuscata, Sus scrofa, Xenopus laevis	-	the enzyme belongs to the A1 peptidase family	668809

CAS REGISTRY NUMBER	COMMENTARY
9012-71-9	-

ORGANISM	COMMENTARY	LITERATURE	SEQUENCE CODE	SEQUENCE DB	SOURCE
Bos taurus	-	36853	-	-
Capra hircus	-	36860	-	-
Dicentrarchus labrax	-	684879	-	-
Epinephelus coioides	-	686228	-	-
Homo sapiens	-	35006, 35012, 36845, 36847, 36848, 36849, 36851, 36856, 36858, 36861, 36862, 36864, 36865, 36868, 652641, 667343, 668809, 709708	-	-
Homo sapiens	-	718005	P20142	UniProt
Macaca fuscata	fuscata	36866	-	-
Macaca fuscata	japanese macaque	668809	-	-
Rattus norvegicus	-	36850, 36855, 36867, 709708	-	-
Suncus murinus	pepsin C-1 and C-2	36846	-	-
Sus scrofa	-	36852, 36854, 36856, 36857, 36859, 36863, 668809	-	-
Xenopus laevis	-	668809	-	-

GENERAL INFORMATION	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
physiological function	Homo sapiens	P20142	the major useful function of progastricsin (PGC) includes production of pro-antimicrobial substance in seminal plasma. The action of PGC in the stomach is to degrade dietary proteins. However, in seminal fluid, it activates defensins for local antimicrobial defense. On the other hand, intracellular proprotein activation by PGC in acidic organelle, such as in proSP-B proteolysis, is important on the processing in the secretory pathway of alveolar type-2 cells	718005

SUBSTRATE	PRODUCT	REACTION DIAGRAM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY/ Substrate	LITERATURE/ Substrate	COMMENTARY/ Product	LITERATURE/ Product	Reversibility r=reversible ir=irreversible ?=not specified
acetyl-Ala-Leu-Val-His-NH2 + H2O	?		Sus scrofa	-	very low activity	36857	-	-	?
acetyl-Ala-Leu-Val-His-OH + H2O	?		Sus scrofa	-	very low activity	36857	-	-	?
acetyl-Ala-Phe-Leu-Val-His-NH2 + H2O	?		Homo sapiens, Sus scrofa	-	-	36856	-	-	?
acetyl-Ala-Phe-Leu-Val-His-NH2 + H2O	?		Sus scrofa	-	-	36857	-	-	?
acetyl-Phe-Leu-Val-His methyl ester + H2O	?		Sus scrofa	-	-	36857	-	-	?
acetyl-Phe-Leu-Val-His-NH2 + H2O	?		Homo sapiens, Sus scrofa	-	-	36856	-	-	?
acetyl-Phe-Leu-Val-His-NH2 + H2O	?		Sus scrofa	-	-	36857	-	-	?
acetyl-Tyr-Leu-Val-His methyl ester + H2O	?		Homo sapiens, Sus scrofa	-	-	36856	-	-	?
acetyl-Tyr-Leu-Val-His methyl ester + H2O	?		Sus scrofa	-	-	36857	-	-	?
acetyl-Tyr-Leu-Val-His-NH2 + H2O	?		Homo sapiens, Sus scrofa	-	-	36856	-	-	?
acetyl-Tyr-Leu-Val-His-NH2 + H2O	?		Sus scrofa	-	-	36857	-	-	?
acetyl-Tyr-Leu-Val-His-OH + H2O	?		Sus scrofa	-	-	36857	-	-	?
Albumin + H2O	?		Homo sapiens	-	-	36861	-	-	?
Hemoglobin + H2O	?		Homo sapiens	-	-	36858	-	-	?
Hemoglobin + H2O	?		Sus scrofa	-	-	36859	-	-	?
Hemoglobin + H2O	?		Xenopus laevis	-	-	668809	-	-	?
Hemoglobin + H2O	?		Capra hircus	-	-	36860	-	-	?
Hemoglobin + H2O	?		Macaca fuscata	-	-	36866	-	-	?
Hemoglobin + H2O	?		Homo sapiens	-	acid denatured hemoglobin	36848	-	-	?
Hemoglobin + H2O	?		Suncus murinus	-	pepsin C1 and C2	36846	-	-	?
insulin B chain + H2O	?		Macaca fuscata	-	cleavage of sites Leu15-Tyr16 and Tyr16-Leu17	668809	-	-	?
N-acetyl-L-phenylalanyl-L-diiodotyrosine + H2O	?		Bos taurus	-	-	36853	-	-	?
N-acetyl-L-phenylalanyl-L-diiodotyrosine + H2O	?		Sus scrofa	-	weak activity	36859	-	-	?
N-acetyl-L-phenylalanyl-L-diiodotyrosine + H2O	?		Macaca fuscata	-	scarcely hydrolyzed	36866	-	-	?
oxidized insulin B chain + H2O	?		Sus scrofa	-	major site of attack are the bonds Tyr16-Leu17, 86%, Phe24-Phe25, 82%, His10-Leu11, 46%, Ala14-Leu15, 44%, Gly13-Ala14, 34%	36859	-	-	?
oxidized insulin B chain + H2O	?		Suncus murinus	-	pepsin C-1	36846	-	-	?
Oxidized insulin B-chain + H2O	?		Homo sapiens	-	-	652641	-	652641	?
Pro-Thr-Glu-Phe-(NO2)Phe-Arg-Leu + H2O	?		Homo sapiens	-	-	36847	-	-	?
Pro-Thr-Glu-Phe-(NO2)Phe-Arg-Leu + H2O	?		Sus scrofa	-	-	36852	-	-	?
reduced and carboxymethylated ribonuclease A + H2O	?		Homo sapiens	-	-	652641	-	652641	?
Leu-Ser-(4-nitro)Phe-norleucine-Ala-Leu methyl ester + H2O	?		Bos taurus	-	-	36853	-	-	?
additional information	?	-	Bos taurus	-	clotting activity with kappa-casein is only half of that of chymosin and pepsin A	36853	-	-	-
additional information	?	-	Homo sapiens	-	progastricsin is responsible for the autoproteolysis of seminal fluid proteins under acidic conditions. This suggests that the function of the enzyme is to degrade seminal fluid proteins deposited in the vagina, this in turn may decrease the antigenic load in the vagina and prevent immuno-infertility	36864	-	-	-
additional information	?	-	Rattus norvegicus	-	transcriptional regulation of the pepsinogen C gene, presence of a DNA-binding protein that specifically binds to the promoter region of the rat pepsinogen C gene	36850	-	-	-
additional information	?	-	Homo sapiens	-	pepsinogen C expression by human mammary epithelium may be involved in the development of breast diseases	36861	-	-	-
additional information	?	-	Homo sapiens	-	the enzyme shows very high gastric antibacterial efficiency against Helicobacter pylori at pH 2.0	667343	-	-	-
additional information	?	-	Dicentrarchus labrax	-	role of this gastric digestive enzyme in the regulation of food intake	684879	-	-	-

NATURAL SUBSTRATES	NATURAL PRODUCTS	REACTION DIAGRAM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY SUBSTRATE	LITERATURE (Substrate)	COMMENTARY PRODUCT	LITERATURE (Product)
additional information	?	-	Homo sapiens	-	progastricsin is responsible for the autoproteolysis of seminal fluid proteins under acidic conditions. This suggests that the function of the enzyme is to degrade seminal fluid proteins deposited in the vagina, this in turn may decrease the antigenic load in the vagina and prevent immuno-infertility	36864	-	-
additional information	?	-	Rattus norvegicus	-	transcriptional regulation of the pepsinogen C gene, presence of a DNA-binding protein that specifically binds to the promoter region of the rat pepsinogen C gene	36850	-	-
additional information	?	-	Homo sapiens	-	pepsinogen C expression by human mammary epithelium may be involved in the development of breast diseases	36861	-	-
additional information	?	-	Homo sapiens	-	the enzyme shows very high gastric antibacterial efficiency against Helicobacter pylori at pH 2.0	667343	-	-
additional information	?	-	Dicentrarchus labrax	-	role of this gastric digestive enzyme in the regulation of food intake	684879	-	-

COFACTOR	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
No entries in this field

METALS and IONS	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

INHIBITORS	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
1,2-epoxy-(p-nitrophenoxy)propane	Bos taurus	-	-	36853	2D-image
1,2-Epoxy-3-(p-nitrophenoxy)propane	Macaca fuscata	-	-	36866	2D-image
Acetyl-Phe	Sus scrofa	-	hydrolysis of acetyl-Phe-Leu-Val-His-amide	36857	2D-image
alpha2-Macroglobulin	Homo sapiens	-	activity with reduced and carboxymethylated ribonuclease A is significantly inhibited, activity with oxidized insulin B-chain is scarcely inhibited	652641	-
Diazoacetyl-DL-norleucine methyl ester	Bos taurus	-	-	36853	2D-image
Diazoacetyl-DL-norleucine methyl ester	Macaca fuscata	-	-	36866	2D-image
isovaleryl pepstatin	Homo sapiens	-	-	36847	-
L-363,564	Homo sapiens	-	a statyl peptide based on renin substrate angiotensinogen	36849	2D-image
L-364099	Homo sapiens	-	-	36849	-
p-Bromophenylacyl bromide	Macaca fuscata	-	-	36866	2D-image
Pepstatin	Suncus murinus	-	100 molar excess amount is needed for the complete inhibition of activity of pepsin C-1 and C-2	36846	2D-image
Pepstatin	Homo sapiens	-	-	36848	2D-image
Pepstatin	Capra hircus	-	needs about 100fold molar excess for complete inhibition	36860	2D-image
Pepstatin	Xenopus laevis	-	-	668809	2D-image
pepstatin A	Homo sapiens	-	-	36861	2D-image
[1S-(1R,2R,3S*)]-[N-(4-morpholinylsulfonyl)-L-phenylalanyl]-N-[1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-4,5-didehydro-L-norvalinamide	Homo sapiens	-	-	36865	-
[1S-(1R,2R,4S*)]-[N-(4-morpholinylsulfonyl)-L-phenylalanyl]-N-[1-(cyclohexylmethyl)-2,4-dihydroxy-5-methylhexyl]-4,5-didehydro-L-norvalinamide	Homo sapiens	-	-	36865	-
[1S-[1R[R(R)],2R,4S*]]-[N-(4-morpholinylsulfonyl)-L-phenylalanyl]-N-[1-(cyclohexylmethyl)-2,4-dihydroxyhexyl]-N6-[(methylamino)thioxomethyl]-L-lysinamide	Homo sapiens	-	-	36865	-
Lactoyl-pepstatin	Homo sapiens	-	very weakly	36847	-
additional information	Homo sapiens	-	the pepsin C activity decreases due to its autocatalytical activity	667343	-

ACTIVATING COMPOUND	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
No entries in this field

KM VALUE [mM]	KM VALUE [mM] Maximum	SUBSTRATE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
0.51	-	acetyl-Ala-Phe-Leu-Val-His-NH2	Homo sapiens	-	-	36856	2D-image
0.7	-	acetyl-Ala-Phe-Leu-Val-His-NH2	Sus scrofa	-	-	36856, 36857	2D-image
1.84	-	acetyl-Phe-Leu-Val-His methyl ester	Sus scrofa	-	-	36857	2D-image
1.84	-	acetyl-Phe-Leu-Val-His-NH2	Sus scrofa	-	-	36856, 36857	2D-image
2.76	-	acetyl-Phe-Leu-Val-His-NH2	Homo sapiens	-	-	36856	2D-image
0.28	-	acetyl-Tyr-Leu-Val-His methyl ester	Sus scrofa	-	-	36856	2D-image
0.28	-	acetyl-Tyr-Leu-Val-His methyl ester	Sus scrofa	-	Km-value for the range 0.025-0.15 mM	36857	2D-image
1.71	-	acetyl-Tyr-Leu-Val-His methyl ester	Sus scrofa	-	Km-value for the range 0.025-1.0 mM	36857	2D-image
0.82	-	acetyl-Tyr-Leu-Val-His-NH2	Sus scrofa	-	-	36856	2D-image
0.82	-	acetyl-Tyr-Leu-Val-His-NH2	Sus scrofa	-	Km-value for the range 0.1-0.5 mM	36857	2D-image
4.31	-	acetyl-Tyr-Leu-Val-His-NH2	Sus scrofa	-	Km-value for the range 0.1-2.0 mM	36857	2D-image
0.82	-	acetyl-Tyr-Leu-Val-His-OH	Sus scrofa	-	-	36857	2D-image
0.098	-	Pro-Thr-Glu-Phe-(NO2)Phe-Arg-Leu	Sus scrofa	-	-	36852	2D-image
0.42	-	Pro-Thr-Glu-Phe-(NO2)Phe-Arg-Leu	Homo sapiens	-	-	36847	2D-image

TURNOVER NUMBER [1/s]	TURNOVER NUMBER MAXIMUM[1/s]	SUBSTRATE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
0.3	-	acetyl-Ala-Phe-Leu-Val-His-NH2	Homo sapiens	-	-	36856	2D-image
7.01	-	acetyl-Ala-Phe-Leu-Val-His-NH2	Sus scrofa	-	-	36856, 36857	2D-image
5.13	-	acetyl-Phe-Leu-Val-His methyl ester	Sus scrofa	-	-	36857	2D-image
0.6	-	acetyl-Phe-Leu-Val-His-NH2	Homo sapiens	-	-	36856	2D-image
6.12	-	acetyl-Phe-Leu-Val-His-NH2	Sus scrofa	-	-	36856, 36857	2D-image
1.06	-	acetyl-Tyr-Leu-Val-His methyl ester	Sus scrofa	-	-	36856	2D-image
1.06	-	acetyl-Tyr-Leu-Val-His methyl ester	Sus scrofa	-	Km-value for the range 0.025-0.15 mM	36857	2D-image
5.76	-	acetyl-Tyr-Leu-Val-His methyl ester	Sus scrofa	-	Km-value for the range 0.025-1.0 mM	36857	2D-image
1.07	-	acetyl-Tyr-Leu-Val-His-NH2	Sus scrofa	-	-	36856	2D-image
1.07	-	acetyl-Tyr-Leu-Val-His-NH2	Sus scrofa	-	Km-value for the range 0.1-0.5 mM	36857	2D-image
1.08	-	acetyl-Tyr-Leu-Val-His-NH2	Sus scrofa	-	-	36857	2D-image
4.45	-	acetyl-Tyr-Leu-Val-His-NH2	Sus scrofa	-	Km-value for the range 0.1-2.0 mM	36857	2D-image
55	-	Pro-Thr-Glu-Phe-(NO2)Phe-Arg-Leu	Sus scrofa	-	-	36852	2D-image

kcat/KM VALUE [1/mMs^-1]	kcat/KM VALUE [1/mMs^-1] Maximum	SUBSTRATE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
No entries in this field

Ki VALUE [mM]	Ki VALUE [mM] Maximum	INHIBITOR	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
No entries in this field

IC50 VALUE [mM]	IC50 VALUE [mM] Maximum	INHIBITOR	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg]	SPECIFIC ACTIVITY MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
additional information	-	Suncus murinus	-	-	36846

pH OPTIMUM	pH MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
2	3	Capra hircus	-	hemoglobin	36860
3	-	Suncus murinus	-	-	36846
3	-	Homo sapiens	-	-	36848
3	-	Macaca fuscata	-	hemoglobin	36866
3.2	-	Homo sapiens	-	-	36858
5	-	Homo sapiens	-	assay at	667343
additional information	-	Sus scrofa	-	-	36857

pH RANGE	pH RANGE MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
1.1	4	Homo sapiens	-	pH 1.1: about 60% of maximal activity, pH 4.0: about 35% of maximal activity	36858
1.2	3.5	Macaca fuscata	-	pH 1.2: about 75% of maximal activity, pH 3.5: about 55% of maximal activity	36866
1.3	4.5	Suncus murinus	-	pH 1.3: about 75% of maximal activity, pH 4.5: about 35% of maximal activity, pepsin C-2	36846
1.4	4.5	Suncus murinus	-	pH 1.4: about 90% of maximal activity, pH 4.5: about 40% of maximal activity, pepsin C-1	36846

TEMPERATURE OPTIMUM	TEMPERATURE OPTIMUM MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

TEMPERATURE RANGE	TEMPERATURE MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

pI VALUE	pI VALUE MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
4.4	-	Epinephelus coioides	-	calculated from sequence	686228

SOURCE TISSUE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	SOURCE
breast	Homo sapiens	-	the enzyme is produced by mammary carcinomas and cysts, but not by the normal resting mammary gland	36861
breast cancer cell	Homo sapiens	-	-	668809
breast cyst	Homo sapiens	-	-	668809
esophagus	Epinephelus coioides	-	pepsinogen C transcript is first detected at 41 days post hatching and continuously expressed through to adult fish	686228
gastric juice	Homo sapiens	-	-	36851, 36858, 668809
gastric juice	Sus scrofa	-	-	668809
gastric mucosa	Homo sapiens	-	-	35012, 36851, 36868, 718005
gastric mucosa	Suncus murinus	-	-	36846
gastric mucosa	Rattus norvegicus	-	-	36855, 36867
gastric mucosa	Macaca fuscata	-	-	36866
gastric tract	Homo sapiens	-	-	667343
gastric tract	Sus scrofa	-	-	668809
gastroduodenal mucosa	Homo sapiens	P20142	-	718005
gastrointestinal tract	Homo sapiens, Macaca fuscata, Xenopus laevis	-	-	668809
gill	Epinephelus coioides	-	pepsinogen C transcript is first detected at 41 days post hatching and continuously expressed through to adult fish	686228
ovary	Epinephelus coioides	-	pepsinogen C transcript is first detected at 41 days post hatching and continuously expressed through to adult fish	686228
ovary	Homo sapiens	P20142	-	718005
pancreas	Homo sapiens	P20142	-	718005
prostate gland	Homo sapiens	-	-	36848, 668809, 718005
pyloric cecum	Epinephelus coioides	-	pepsinogen C transcript is first detected at 41 days post hatching and continuously expressed through to adult fish	686228
semen	Homo sapiens	-	-	36847, 36864
seminal fluid	Homo sapiens	P20142	-	718005
seminal plasma	Homo sapiens	-	-	668809, 718005
seminal vesicle	Homo sapiens	-	synthesis	668809
seminal vesicle	Homo sapiens	P20142	-	718005
serum	Homo sapiens	-	-	668809
stomach	Sus scrofa	-	-	36859, 668809
stomach	Homo sapiens	-	-	667343, 668809, 718005
stomach	Dicentrarchus labrax	-	progastricsin mRNA copy number is downregulated under conditions of negative energy balance, such as starvation, and upregulated during positive energy balance, such as refeeding. Role of the enzyme in the regulation of food intake	684879
stomach	Epinephelus coioides	-	primarily distributed in. Pepsinogen C transcript is first detected at 41 days post hatching and continuously expressed through to adult fish	686228
vaginal fluid	Homo sapiens	-	-	668809
intestine	Epinephelus coioides	-	pepsinogen C transcript is first detected at 41 days post hatching and continuously expressed through to adult fish	686228
additional information	Homo sapiens	-	no expression in healthy breast tissue, reabsorption of zymogen from serum into kidney	668809

LOCALIZATION	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	GeneOntology No.	LITERATURE	SOURCE
extracellular	Homo sapiens	-	in gastric juice, vaginal fluid, serum, and seminal plasma, no secretion in urine	-	668809
extracellular	Macaca fuscata, Sus scrofa, Xenopus laevis	-	in gastric juice	-	668809

PDB	SCOP	CATH	ORGANISM
1avf, download	SCOP (1avf)	CATH (1avf)	Homo sapiens
1htr, download	SCOP (1htr)	CATH (1htr)	Homo sapiens

MOLECULAR WEIGHT	MOLECULAR WEIGHT MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
27000	-	Macaca fuscata	-	the MW of pepsinogen C is 35000 Da, gel filtration	36866
32800	-	Bos taurus	-	gel filtration	36853
35460	-	Homo sapiens	-	calculation from nucleotide sequence; electrospray mass spectrometry	35006
41400	-	Sus scrofa	-	calculation from amino acid composition	36854
additional information	-	Homo sapiens	-	amino acid sequence, 24 residues, near the amino terminus	36845
additional information	-	Suncus murinus	-	pepsinogen C-1, 39000 Da, SDS-PAGE; pepsinogen C-2, 41000 Da, SDS-PAGE	36846

SUBUNITS	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
?	Capra hircus	-	x * 39000, pepsinogen C-1 and pepsinogen C-2, SDS-PAGE	36860
?	Rattus norvegicus	-	x * 41206, calculation from nucleotide sequence	36867
?	Homo sapiens	P20142	x * 40000, calculated from amino acid sequence	718005
additional information	Homo sapiens	-	secondary and tertiary structure determination	668809
additional information	Macaca fuscata	-	structure determination	668809

POSTTRANSLATIONAL MODIFICATION	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
proteolytic modification	Capra hircus	-	pepsinogen C-1 and C-2	36860
proteolytic modification	Homo sapiens	-	zymogen: progastricsin	35006
proteolytic modification	Homo sapiens	-	progastricsin, MW 34000 Da is converted by acid activation to gastricsin, 31000 Da; zymogen: progastricsin	36847
proteolytic modification	Homo sapiens	-	-	36848
proteolytic modification	Homo sapiens	-	zymogen: pepsinogen C	36861
proteolytic modification	Homo sapiens	-	the pepsin C activity decreases due to its autocatalytical activity	667343
proteolytic modification	Homo sapiens	-	the zymogen pepsinogen C is activated after secretion	668809
no modification	Macaca fuscata	-	contains no carbohydrate	36866
proteolytic modification	Macaca fuscata	-	zymogen: pepsinogen C	36866
proteolytic modification	Macaca fuscata	-	the zymogen pepsinogen C is activated after secretion	668809
proteolytic modification	Rattus norvegicus	-	zymogen: pepsinogen C	36855
proteolytic modification	Suncus murinus	-	pepsinogen C-1 and C-2, each pepsinogen is converted to pepsin through an intermediate form under acidic conditions	36846
side-chain modification	Suncus murinus	-	pepsinogen C-2 contains an Asn-linked carbohydrate chain of about 2000 Da	36846
proteolytic modification	Sus scrofa	-	zymogen: pepsinogen C	36854
proteolytic modification	Sus scrofa	-	zymogen: progastricsin	36863
proteolytic modification	Sus scrofa, Xenopus laevis	-	the zymogen pepsinogen C is activated after secretion	668809

Crystallization/COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
crystal structure determination	Homo sapiens	-	668809
molecular structure and comparison with that of porcine pepsinogen	Homo sapiens	-	35012

pH STABILITY	pH STABILITY MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

TEMPERATURE STABILITY	TEMPERATURE STABILITY MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

GENERAL STABILITY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
the pepsin C activity decreases due to its autocatalytical activity	Homo sapiens	-	667343

ORGANIC SOLVENT	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

OXIDATION STABILITY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
No entries in this field

STORAGE STABILITY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
No entries in this field

Purification/COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
-	Bos taurus	-	36853
pepsinogen C1- and C-2	Capra hircus	-	36860
-	Homo sapiens	-	36848
native zymogen from stomach, prostate, breast cysts fluid, and seminal plasma, native mature enzyme from gastric fluid by anion exchange chromatography	Homo sapiens	-	668809
rapid single-step separation of pepsin from gastricsin from crude human gastric juice and prepurified gastric mucosa extract	Homo sapiens	-	36851
native zymogen	Macaca fuscata	-	668809
pepsinogen C-1 and C-2	Suncus murinus	-	36846
-	Sus scrofa	-	36854
native enzyme from stomach	Sus scrofa	-	668809
native zymogen	Xenopus laevis	-	668809

Cloned/COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
-	Dicentrarchus labrax	-	684879
-	Epinephelus coioides	-	686228
-	Homo sapiens	-	36862, 36868
location on chromosome 6	Homo sapiens	-	668809
-	Rattus norvegicus	-	36867
DNA sequence determination	Xenopus laevis	-	668809

EXPRESSION	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
the decrease of progastricsin expression indicates dedifferentiation or malignancy of cancer cells	Homo sapiens	P20142	718005
progasticsin gene expression is up-regulated following gastrin, secretin, and forskolin stimulation of adenylate cyclase activity	Homo sapiens	P20142	718005

ENGINEERING	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

Renatured/COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
No entries in this field

APPLICATION	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
medicine	Homo sapiens	-	potential interest as a biochemical marker of the hormonal imbalance underlying these pathologies	36861
medicine	Homo sapiens	P20142	the tissue expression of progatricsin represents a powerful tool for the diagnosis of prostate cancer. The enzyme is also a biomarker for gastric carcinoma and plays a direct role in the development of breast tumor progression	718005

DISEASE	TITLE OF PUBLICATION	LINK TO PUBMED
Acquired Immunodeficiency Syndrome	Serum pepsinogen and gastrin levels in HIV-positive patients: relationship with CD4+ cell count and Helicobacter pylori infection.	PubMed
Adenocarcinoma	Identification of primary tumour site by immunolocalization of progastricsin in metastatic adenocarcinoma.	PubMed
Adenocarcinoma	The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.	PubMed
Anemia, Pernicious	Pepsinogens A and C: purification from human gastric mucosa and determination in serum by optimized radioimmunoassays.	PubMed
Aspermia	The concentration of pepsinogen C in human semen and the physiological activation of zymogen in the vagina.	PubMed
Barrett Esophagus	Gastric proteases in Barrett's esophagus.	PubMed
Barrett Esophagus	Pepsinogen C: a possible biological marker of epithelial differentiation in Barrett's esophagus.	PubMed
Breast Cyst	Immunofluorometric assay of pepsinogen C and preliminary clinical applications.	PubMed
Breast Cyst	Quantification of pepsinogen C and prostaglandin D synthase in breast cyst fluid and their potential utility for cyst type classification.	PubMed
Breast Diseases	Expression of pepsinogen C in gynecomastias and male breast carcinomas.	PubMed
Breast Diseases	Immunofluorometric assay of pepsinogen C and preliminary clinical applications.	PubMed
Breast Diseases	Isolation and characterization of a pepsin C zymogen produced by human breast tissues.	PubMed
Breast Neoplasms	Clinical significance of pepsinogen C tumor expression in patients with stage D2 prostate carcinoma.	PubMed
Breast Neoplasms	Expression and clinical significance of pepsinogen C in epithelial ovarian carcinomas.	PubMed
Breast Neoplasms	Expression and clinical significance of pepsinogen C in resectable pancreatic cancer.	PubMed
Breast Neoplasms	Expression of pepsinogen C in human breast tumours and correlation with clinicopathologic parameters.	PubMed
Breast Neoplasms	Hormonal regulation of the human pepsinogen C gene in breast cancer cells. Identification of a cis-acting element mediating its induction by androgens, glucocorticoids, and progesterone.	PubMed
Breast Neoplasms	Immunoenzymatically determined pepsinogen C concentration in breast tumor cytosols: an independent favorable prognostic factor in node-positive patients.	PubMed
Breast Neoplasms	Immunofluorometric assay of pepsinogen C and preliminary clinical applications.	PubMed
Breast Neoplasms	Immunohistochemical study of pepsinogen C expression in cutaneous malignant melanoma: association with clinicopathological parameters.	PubMed
Breast Neoplasms	Overall survival in women with breast cancer: the influence of pepsinogen C gene polymorphism.	PubMed
Breast Neoplasms	Pepsinogen C is a new prognostic marker in primary breast cancer.	PubMed
Breast Neoplasms, Male	Expression of pepsinogen C in gynecomastias and male breast carcinomas.	PubMed
Carcinoma	Clinical significance of pepsinogen C tumor expression in patients with stage D2 prostate carcinoma.	PubMed
Carcinoma	Expression and clinical significance of pepsinogen C in epithelial ovarian carcinomas.	PubMed
Carcinoma	Expression and clinical significance of pepsinogen C in resectable pancreatic cancer.	PubMed
Carcinoma	Expression and prognostic significance of pepsinogen C in gastric carcinoma.	PubMed
Carcinoma	Expression of pepsinogen C in gynecomastias and male breast carcinomas.	PubMed
Carcinoma	Expression of pepsinogen C in human breast tumours and correlation with clinicopathologic parameters.	PubMed
Carcinoma	Expression of two androgen-induced proteins (pepsinogen C and apolipoprotein d) in epithelial skin cancers of the eyelids.	PubMed
Carcinoma	Immunofluorometric assay of pepsinogen C and preliminary clinical applications.	PubMed
Carcinoma	Immunolocalisation of aspartic proteinases in the developing human stomach.	PubMed
Carcinoma	Pepsinogen C expression in tumors of extragastric origin.	PubMed
Carcinoma	Pepsinogen C is a new prognostic marker in primary breast cancer.	PubMed
Carcinoma	[An immunohistochemical study of pepsinogen type C in the gastric mucosa and in stomach cancer]	PubMed
Carcinoma	[Immunohistologic detection of pepsin and gastricsin in carcinoma of the stomach]	PubMed
Carcinoma, Ductal	Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast.	PubMed
Carcinoma, Ductal	Expression of pepsinogen C in gynecomastias and male breast carcinomas.	PubMed
Carcinoma, Intraductal, Noninfiltrating	Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast.	PubMed
Carcinoma, Squamous Cell	Expression of two androgen-induced proteins (pepsinogen C and apolipoprotein d) in epithelial skin cancers of the eyelids.	PubMed
Cysts	Quantification of pepsinogen C and prostaglandin D synthase in breast cyst fluid and their potential utility for cyst type classification.	PubMed
Duodenal Ulcer	Different effects of H. pylori water extracts on cytokines, pepsinogen C and gastrin mucosal release in patients with or without duodenal ulcer.	PubMed
Duodenal Ulcer	Effect of intermittent administration of omeprazole on serum pepsinogens in duodenal ulcer patients and healthy volunteers.	PubMed
Duodenal Ulcer	Genetic heterogeneity of combined gastric and duodenal ulcers detected by pepsinogen C gene polymorphism.	PubMed
Duodenal Ulcer	Seroepidemiology of gastritis in Japanese and Dutch male employees with and without ulcer disease.	PubMed
Endocrine System Diseases	[Clinico-morphologic criteria for prognosis of stomach cancer]	PubMed
Gastritis	Clinical implications of serum pepsinogen and progastricsin in man.	PubMed
Gastritis	Cure of Helicobacter pylori infection in the elderly: effects of eradication on gastritis and serological markers.	PubMed
Gastritis	Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.	PubMed
Gastritis	Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.	PubMed
Gastritis	Seroepidemiology of gastritis in Japanese and Dutch male employees with and without ulcer disease.	PubMed
Gastritis	Seroepidemiology of gastritis in Japanese and Dutch working populations: evidence for the development of atrophic gastritis that is not related to Helicobacter pylori.	PubMed
Gastritis	Serological parameters in assessment of degree of gastritis in healthy volunteers.	PubMed
Gastritis, Atrophic	Free and protein-bound cobalamin absorption in healthy middle-aged and older subjects.	PubMed
Gastritis, Atrophic	Helicobacter pylori, pepsinogens and gastrin: relationship with age and development of atrophic gastritis.	PubMed
Gastritis, Atrophic	Serum anti-Helicobacter pylori IgG antibodies and pepsinogens A and C as serological markers of chronic atrophic gastritis.	PubMed
Gastritis, Atrophic	The effect of Helicobacter pylori eradication therapy on dyspepsia symptoms in industrial workers in Japan.	PubMed
Gastritis, Atrophic	The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.	PubMed
Gynecomastia	Expression of pepsinogen C in gynecomastias and male breast carcinomas.	PubMed
Infection	Association between genetic polymorphism of the pepsinogen C gene and gastric body ulcer: the genetic predisposition is not associated with Helicobacter pylori infection.	PubMed
Infection	Clinical implications of serum pepsinogen and progastricsin in man.	PubMed
Infection	Cure of Helicobacter pylori infection in the elderly: effects of eradication on gastritis and serological markers.	PubMed
Infection	Dynamic expression of pepsinogen C in gastric cancer, precancerous lesions and Helicobacter pylori associated gastric diseases.	PubMed
Infection	Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.	PubMed
Infection	Helicobacter pylori serology in patients with chronic gastritis.	PubMed
Infection	Helicobacter pylori, pepsinogens and gastrin: relationship with age and development of atrophic gastritis.	PubMed
Infection	Serum pepsinogen and gastrin levels in HIV-positive patients: relationship with CD4+ cell count and Helicobacter pylori infection.	PubMed
Infection	[Interaction between an insertion/deletion polymorphism in pepsinogen C and Helicobacter pylori infection in the development of gastric cancer]	PubMed
Infertility, Male	The concentration of pepsinogen C in human semen and the physiological activation of zymogen in the vagina.	PubMed
Melanoma	Expression and clinical significance of pepsinogen C in uveal melanomas.	PubMed
Melanoma	Immunohistochemical study of pepsinogen C expression in cutaneous malignant melanoma: association with clinicopathological parameters.	PubMed
Melanoma	Pepsinogen C expression in tumors of extragastric origin.	PubMed
Neoplasm Metastasis	Identification of primary tumour site by immunolocalization of progastricsin in metastatic adenocarcinoma.	PubMed
Neoplasm Metastasis	[Immunohistologic detection of pepsin and gastricsin in carcinoma of the stomach]	PubMed
Neoplasms	Characterization of pepsinogen C as a potential biomarker for gastric cancer using a histo-proteomic approach.	PubMed
Neoplasms	Clinical implications of serum pepsinogen and progastricsin in man.	PubMed
Neoplasms	Clinical significance of pepsinogen C tumor expression in patients with stage D2 prostate carcinoma.	PubMed
Neoplasms	Expression and clinical significance of pepsinogen C in uveal melanomas.	PubMed
Neoplasms	Expression and prognostic significance of pepsinogen C in gastric carcinoma.	PubMed
Neoplasms	Expression of pepsinogen C in gynecomastias and male breast carcinomas.	PubMed
Neoplasms	Expression of pepsinogen C in human breast tumours and correlation with clinicopathologic parameters.	PubMed
Neoplasms	Identification of primary tumour site by immunolocalization of progastricsin in metastatic adenocarcinoma.	PubMed
Neoplasms	Pepsinogen A/pepsinogen C or pepsinogen A multiplied by gastrin in the diagnosis of gastric cancer?	PubMed
Neoplasms	Pepsinogen C expression in tumors of extragastric origin.	PubMed
Neoplasms	Pepsinogen C is a new prognostic marker in primary breast cancer.	PubMed
Neoplasms	Seroepidemiology of gastritis in Japanese and Dutch working populations: evidence for the development of atrophic gastritis that is not related to Helicobacter pylori.	PubMed
Neoplasms	The role of prostate specific membrane antigen and pepsinogen C tissue expression as an adjunctive method to prostate cancer diagnosis.	PubMed
Neoplasms	[Clinico-morphologic criteria for prognosis of stomach cancer]	PubMed
Neoplasms	[Immunohistologic detection of pepsin and gastricsin in carcinoma of the stomach]	PubMed
Neoplasms	[Immunomorphologic study of pepsinogens in stomach cancer]	PubMed
Nevus, Pigmented	Immunohistochemical study of pepsinogen C expression in cutaneous malignant melanoma: association with clinicopathological parameters.	PubMed
Pancreatic Neoplasms	Expression and clinical significance of pepsinogen C in resectable pancreatic cancer.	PubMed
Peptic Ulcer	Association between genetic polymorphism of the pepsinogen C gene and gastric body ulcer: the genetic predisposition is not associated with Helicobacter pylori infection.	PubMed
Peptic Ulcer	Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.	PubMed
Peptic Ulcer	Prospective study of the effect of gastrectomy with and without bile reflux on serum pepsinogens.	PubMed
Peptic Ulcer	[Pepsin and gastricsin secretion in the course of digestion in peptic ulcer and in health]	PubMed
Precancerous Conditions	Impact of pepsinogen C polymorphism on individual susceptibility to gastric cancer and its precancerous conditions in a Northeast Chinese population.	PubMed
Prostatic Hyperplasia	The role of prostate specific membrane antigen and pepsinogen C tissue expression as an adjunctive method to prostate cancer diagnosis.	PubMed
Prostatic Neoplasms	Clinical significance of pepsinogen C tumor expression in patients with stage D2 prostate carcinoma.	PubMed
Prostatic Neoplasms	Immunofluorometric assay of pepsinogen C and preliminary clinical applications.	PubMed
Prostatic Neoplasms	The role of prostate specific membrane antigen and pepsinogen C tissue expression as an adjunctive method to prostate cancer diagnosis.	PubMed
Renal Insufficiency, Chronic	Renal handling of pepsinogens A and C in man.	PubMed
Starvation	Regulation of progastricsin mRNA levels in sea bass (Dicentrarchus labrax) in response to fluctuations in food availability.	PubMed
Stomach Diseases	Clinical implications of serum pepsinogen and progastricsin in man.	PubMed
Stomach Diseases	Dynamic expression of pepsinogen C in gastric cancer, precancerous lesions and Helicobacter pylori associated gastric diseases.	PubMed
Stomach Neoplasms	Association between pepsinogen C gene polymorphism and genetic predisposition to gastric cancer.	PubMed
Stomach Neoplasms	Characterization of pepsinogen C as a potential biomarker for gastric cancer using a histo-proteomic approach.	PubMed
Stomach Neoplasms	Clinical implications of serum pepsinogen and progastricsin in man.	PubMed
Stomach Neoplasms	Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.	PubMed
Stomach Neoplasms	Dynamic expression of pepsinogen C in gastric cancer, precancerous lesions and Helicobacter pylori associated gastric diseases.	PubMed
Stomach Neoplasms	Expression and prognostic significance of pepsinogen C in gastric carcinoma.	PubMed
Stomach Neoplasms	Gastric cancer in a Caucasian population: role of pepsinogen C genetic variants.	PubMed
Stomach Neoplasms	Impact of pepsinogen C polymorphism on individual susceptibility to gastric cancer and its precancerous conditions in a Northeast Chinese population.	PubMed
Stomach Neoplasms	Pepsinogen A/pepsinogen C or pepsinogen A multiplied by gastrin in the diagnosis of gastric cancer?	PubMed
Stomach Neoplasms	RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.	PubMed
Stomach Neoplasms	[Correlation between an insertion-deletion polymorphism in the pepsinogen C gene and gastric cancer as well as its precursors]	PubMed
Stomach Neoplasms	[Expression of pepsinogen C in gastric cancer and its precursor]	PubMed
Stomach Neoplasms	[Interaction between an insertion/deletion polymorphism in pepsinogen C and Helicobacter pylori infection in the development of gastric cancer]	PubMed
Stomach Ulcer	Genetic heterogeneity of combined gastric and duodenal ulcers detected by pepsinogen C gene polymorphism.	PubMed
Stomach Ulcer	Pepsinogen C gene polymorphisms associated with gastric body ulcer.	PubMed
Stomach Ulcer	The expression of pepsinogen c mRNA in normal gastroduodenal mucosa and the gastric ulcer margin of the rat.	PubMed

REF.	AUTHORS	TITLE	JOURNAL	VOL.	PAGES	YEAR	ORGANISM	LINK TO PUBMED	SOURCE
35006	Jones, A.T.; Green, B.N.; Wood, S.P.; Roberts, N.B.	The amino terminal sequences of acid proteases-human pepsin and gastricsin and the protease of Rhizopus chinensis	Aspartic Proteinases: Structure, Function, Biology and Biomedical Implications (Takahashi, K., ed.), Plenum Press, New York		83-89	1995	Homo sapiens	PubMed
35012	James, M.; Moore, S.; Sielecki, A.; Chernaia, M.; Tarasova, N.	Pepsinogens and pepsins from house musk shrew, Suncus murinus: purification, characterization, determination of the amino-acid sequences of the activation segments, and analysis of proteolytic specificities	Aspartic Proteinases: Structure, Function, Biology and Biomedical Implications (Takahashi, K., ed.), Plenum Press, New York		11-18	1995	Homo sapiens	PubMed
36845	Sepulveda, P.; Jackson, K.W.; Tang, J.	Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate	Biochem. Biophys. Res. Commun.	63	1106-1112	1975	Homo sapiens	PubMed
36846	Narita, Y.; Oda, S.; Moriyama, A.; Takenaka, O.; Kageyama, T.	Human prostatic gastric sinogen: the precursor of seminal fluid acid proteinase	J. Biochem.	121	1010-1017	1997	Suncus murinus	PubMed
36847	Reid, W.A.; Vongsorasak, L.; Svasti, J.; Valler, M.J.; Kay, J.	X-ray studies of aspartic proteinase-statine inhibitor complexes	Cell Tissue Res.	236	597-600	1984	Homo sapiens	PubMed
36848	Chiang, L.; Contreras, L.; Chiang, J.; Ward, P.H.	Primary structure and transcriptional regulation of rat pepsinogen C gene	Arch. Biochem. Biophys.	210	14-20	1981	Homo sapiens	PubMed
36849	Cooper, J.B.; Foundling, S.I.; Blundell, T.L.; Boger, J.; Jupp, R.A.; Kay, J.	Separation of human pepsin and gastricsin by affinity chromatography with an immobilized synthetic inhibitor	Biochemistry	28	8596-8603	1989	Homo sapiens	PubMed
36850	Ishihara, T.; Ichihara, Y.; Hayano, T.; Katsura, I.; Sogawa, K.; Fujii-Kuriyama, Y.; Takahashi, K.	Design, synthesis and analysis of new synthetic substrates for the aspartic proteinases	J. Biol. Chem.	264	10193-10199	1989	Rattus norvegicus	PubMed
36851	Kucerova, Z.; Pohl, J.; Korbova, L.	Purification and characterization of bovine gastricsin	J. Chromatogr.	376	409-412	1986	Homo sapiens	PubMed
36852	Dunn, B.M.; Kay, J.	Pepsinogen C and pepsin C. Further purification and amino acid composition	Biochem. Soc. Trans.	13	1041-1043	1985	Sus scrofa	PubMed
36853	Martin, P.; Trieu-Cuot, P.; Collin, J.C.; Ribadeau Dumas, B.	Biochemical and immunological characterizations of rat pepsinogens and pepsins	Eur. J. Biochem.	122	31-39	1982	Bos taurus	PubMed
36854	Ryle, A.P.; Hamilton, M.P.	Pepsinogen C and pepsin C. Further purification and amino acid composition	Biochem. J.	101	176-183	1966	Sus scrofa	PubMed
36855	Muto, N.; Murayama, K.; Akahane, K.; Tani, S.	Biochemical and immunological characterizations of rat pepsinogens and pepsins	J. Biochem.	87	717-723	1980	Rattus norvegicus	PubMed
36856	Ryle, A.P.; Auffret, C.A.	The specificity of some pig and human pepsins towards synthetic peptide substrates	Biochem. J.	179	247-249	1979	Homo sapiens, Sus scrofa	PubMed
36857	Auffret, C.A.; Ryle, A.P.	The catalytic activity of pig pepsin C towards small synthetic substrates	Biochem. J.	179	239-246	1979	Sus scrofa	PubMed
36858	Richmond, V.; Tang, J.; Wolf, S.; Trucco, R.E.; Caputto, R.	Purification and characterization of goat pepsinogens and pepsins	Biochim. Biophys. Acta	29	453-454	1958	Homo sapiens	-
36859	Ryle, A.P.; Leclerc, J.; Falla, F.	Isolation and characterization of a pepsin C zymogen produced by human breast tissues	Biochem. J.	110	4	1968	Sus scrofa	-
36860	Suzuki, M.; Narita, Y.; Oda, S.; Moriyama, A.; Takenaka, O.; Kageyama, T.	Primary structure of human pepsinogen C gene [published erratum appears in J Biol Chem 1988 Oct 5;263(28):14592	Comp. Biochem. Physiol. B	122	453-460	1999	Capra hircus	PubMed
36861	Sanchez, L.M.; Freije, J.P.; Merino, A.M.; Vizoso, F.; Foltmann, B.; Lopez-Otin, C.	Separation of porcine pepsinogen A and progastricsin. Sequencing of the first 73 amino acid residues in progastricsin	J. Biol. Chem.	267	24725-24731	1992	Homo sapiens	PubMed
36862	Hayano, T.; Sogawa, K.; Ichihara, Y.; Fujii-Kuriyama, Y.; Takahashi, K.	Gastricsin-mediated proteolytic degradation of human seminal fluid proteins at pH levels found in the human vagina	J. Biol. Chem.	263	1382-1385	1988	Homo sapiens	PubMed
36863	Foltmann, B.; Drohse, H.B.; Nielsen, P.K.; James, M.N.G.	Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1 -P2 variation	Biochim. Biophys. Acta	1121	75-82	1992	Sus scrofa	PubMed
36864	Szecsi, P.B.; Lilja, H.	Pepsinogen C and pepsin C from gastric mucosa of Japanese monkey. Purification and characterization	J. Androl.	14	351-358	1993	Homo sapiens	PubMed
36865	Rao, C.M.; Scarborough, P.E.; Kay, J.; Batley, B.; Rapundalo, S.; Klutchko, S.; Taylor, M.D.; Lunney, E.A.; Humblet, C.C.; Dunn, B.M.	Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation	J. Med. Chem.	36	2614-2620	1993	Homo sapiens	PubMed
36866	Kageyama, T.; Takahashi, K.	Pepsinogen C and pepsin C from gastric mucosa of Japanese monkey. Purification and characterization	J. Biochem.	80	983-992	1976	Macaca fuscata	PubMed
36867	Ichihara, Y.; Sogawa, K.; Morohashi, K.; Fujii-Kuriyama, Y.; Takahashi, K.	Nucleotide sequence of a nearly full-length cDNA coding for pepsinogen of rat gastric mucosa	Eur. J. Biochem.	161	7-12	1986	Rattus norvegicus	PubMed
36868	Taggart, R.T.; Cass, L.G.; Mohandas, P.; Derby, P.J.; Barr, P.J.; Pals, G.; Bell, G.	Human pepsinogen C (progastricsin). Isolation of cDNA clones, localization to chromosome 6, and sequence homology with pepsinogen A	J. Biol. Chem.	264	375-379	1989	Homo sapiens	PubMed
652641	Athauda, S.B.; Nishigai, M.; Arakawa, H.; Ikai, A.; Ukai, M.; Takahashi, K.	Inhibition of human pepsin and gastricsin by alpha2-macroglobulin	J. Enzyme Inhib. Med. Chem.	18	219-224	2003	Homo sapiens	PubMed
667343	Schreiber, S.; Buecker, R.; Groll, C.; Azevedo-Vethacke, M.; Scheid, P.; Gatermann, S.; Josenhans, C.; Suerbaum, S.	Gastric antibacterial efficiency is different for pepsin A and C	Arch. Microbiol.	184	335-340	2006	Homo sapiens	PubMed
668809	Tang, J.	Gastricsin	Handbook of Proteolytic Enzymes (Barrett, J.; Rawlings, N.D.; Woessner, J.F., eds.)	1	38-43	2004	Homo sapiens, Macaca fuscata, Sus scrofa, Xenopus laevis	-
684879	Terova, G.; Rimoldi, S.; Larghi, S.; Bernardini, G.; Gornati, R.; Saroglia, M.	Regulation of progastricsin mRNA levels in sea bass (Dicentrarchus labrax) in response to fluctuations in food availability	Biochem. Biophys. Res. Commun.	363	591-596	2007	Dicentrarchus labrax	PubMed
686228	Feng, S.; Li, W.; Lin, H.	Characterization and expression of the pepsinogen C gene and determination of pepsin-like enzyme activity from orange-spotted grouper (Epinephelus coioides)	Comp. Biochem. Physiol. B Biochem. Mol. Biol.	149	275-284	2008	Epinephelus coioides	PubMed
709708	Filuszova, M.; Kucerova, Z.; Ticha, M.	Peptide inhibitor modified magnetic particles for pepsin separation	J. Sep. Sci.	32	2017-2021	2009	Homo sapiens, Rattus norvegicus	PubMed
718005	Hassan, M.; Toor, A.; Ahmad, F.	Progastriscin: Structure, function, and its role in tumor progression	J. Mol. Cell Biol.	2	118-127	2010	Homo sapiens	PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 3.4.23.3)

NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM

IUBMB Enzyme Nomenclature

PROSITE Database of protein families and domains

SYSTERS

Protein Mutant Database

InterPro (database of protein families, domains and functional sites)

Mark a special word or phrase in this record:
Select one or more organisms in this record: