Information on EC 3.4.23.16 - HIV-1 retropepsin:
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EC NUMBERCOMMENTARY
3.4.23.16-

RECOMMENDED NAMEGeneOntology No.
HIV-1 retropepsin-

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro
show the reaction diagram		----
specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro
show the reaction diagram		the kinetic mechanism of HIV-1 protease is random, in which products bind to form both binary and ternary enzyme-product complexes, depending on the substrate usedHuman immunodeficiency virus 1-648124
specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro
show the reaction diagram		proteolysis mechanism whereby only one active site Asp is initially protonated. The steps of this mechanism are: asymmetric binding of the substrate, hydration of the peptidic carbonyl by an active site water, proton translocation between the active site Asp residue simultaneously with carbonyl hydrationHuman immunodeficiency virus 1-648146
specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro
show the reaction diagram		flap closing and conformational change mechanism induced by substrate binding in HIV-1 aspartic protease, flap conformations in the active site during the catalytic cycle, molecular dynamic simulations, overviewHuman immunodeficiency virus 1-664137
specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro
show the reaction diagram		the active site structure and conformational flexibilityHuman immunodeficiency virus 1-666873

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
hydrolysis of peptide bond----

PATHWAYKEGG LinkMetaCyc Link
No entries in this field

SYSTEMATIC NAMEIUBMB Comments
No entries in this field

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
CRF01_AE proteaseHuman immunodeficiency virus 1Q90VT5-699902
Gag protease----
HIV aspartyl protease----
HIV PRHuman immunodeficiency virus 1--717302
HIV-1 aspartyl proteaseHuman immunodeficiency virus 1--717185
HIV-1 PRHuman immunodeficiency virus 1--664013, 666078, 681698, 717185, 717709, 717998, 718075, 718373
HIV-1 protease----
HIV-1 proteaseHuman immunodeficiency virus 1--662382, 664013, 664137, 664299, 664605, 664895, 665976, 665991, 666016, 666063, 666078, 666106, 666190, 666873, 666884, 678249, 678341, 678731, 680381, 680778, 680900, 681109, 682522, 707173, 707179, 707180, 707378, 707444, 707528, 707682, 707692, 707721, 707740, 708083, 708383, 708386, 708410, 708877, 709258, 709332, 709443, 709467, 709481, 709579, 709580, 709582, 709592, 709660, 709749, 710216, 710346, 710383, 710390, 710423, 717096, 717302, 717327, 717348, 717709, 717971, 717975, 717976, 717998, 718075, 718370, 718373, 718440
HIV-1 proteaseHuman immunodeficiency virus 1-pentamutated protease: subtype B PMPR, K55C, D25N707512
HIV-1 proteinase----
HIV-1 proteinaseHuman immunodeficiency virus 1--665102, 694787
HIV-1PRHuman immunodeficiency virus 1--707512
HIVPRHuman immunodeficiency virus 1--678341
human immunodeficiency virus 1 retropepsinHuman immunodeficiency virus 1--665102
human immunodeficiency virus type 1 protease----
PRHuman immunodeficiency virus 1--664137, 664895
PR1Human immunodeficiency virus 1Q7SSE3-718370
retropepsin----
retroproteinase----
human immunodeficiency virus type I proteaseHuman immunodeficiency virus 1--709258, 709332
additional informationHuman immunodeficiency virus 1-the enzyme belongs to the peptidase family A2665102

CAS REGISTRY NUMBERCOMMENTARY
144114-21-6-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Human immunodeficiency virus 1-647817, 648166, 648174, 648175, 648176, 717971P03369SwissProtManually annotated by BRENDA team
Human immunodeficiency virus 1-648121, 648122, 648123, 648124, 648125, 648126, 648127, 648128, 648129, 648130, 648131, 648132, 648133, 648134, 648135, 648136, 648137, 648138, 648139, 648140, 648141, 648142, 648144, 648145, 648146, 648147, 648148, 648149, 648150, 648151, 648152, 648153, 648154, 648155, 648156, 648157, 648158, 648159, 648161, 648162, 648163, 648167, 648168, 648169, 648170, 648171, 648172, 648173, 678249, 678341, 678346, 678616, 678626, 678731, 680351, 680381, 680778, 680900, 681109, 681326, 681460, 682227, 682522, 682765, 682770, 682973, 693905, 694787, 695291, 695631, 696116, 697298, 697300, 698516, 699145, 699197, 699546, 699555, 699572, 699630, 699907, 701086, 701133, 701392, 707173, 707179, 707180, 707378, 707444, 707512, 707528, 707682, 707692, 707721, 707740, 708083, 708383, 708386, 708410, 708877, 709258, 709332, 709443, 709467, 709481, 709579, 709580, 709582, 709592, 709660, 709749, 710216, 710346, 710383, 710390, 710423, 717096, 717185, 717302, 717327, 717348, 717709, 717975, 717976, 717998, 718075, 718440--Manually annotated by BRENDA team
Human immunodeficiency virus 1-648164, 681698, 718373P03367UniProtManually annotated by BRENDA team
Human immunodeficiency virus 1-648165P04585UniprotManually annotated by BRENDA team
Human immunodeficiency virus 1-718370Q7SSE3UniProtManually annotated by BRENDA team
Human immunodeficiency virus 1Gag polyprotein699902Q90VT5SwissProtManually annotated by BRENDA team
Human immunodeficiency virus 1i.e. HIV-1662382, 664013, 664137, 664299, 664605, 664895, 665102, 665976, 665991, 666016, 666063, 666078, 666106, 666873, 666884--Manually annotated by BRENDA team
Human immunodeficiency virus 1i.e. HIV-1666190P04587UniprotManually annotated by BRENDA team
Human immunodeficiency virus 1South African subtype C699896--Manually annotated by BRENDA team
Human immunodeficiency virus 1strain HXB2, produced in Escherichia coli648143--Manually annotated by BRENDA team
Human immunodeficiency virus 1subtype G698514--Manually annotated by BRENDA team
Human immunodeficiency virus 1subtypes B and F1698234--Manually annotated by BRENDA team
Human immunodeficiency virus 1the enzyme is chemically synthesized648120--Manually annotated by BRENDA team
Human immunodeficiency virus 1 IIIb-717327--Manually annotated by BRENDA team
Human Immunodeficiency Virus HXB2strain HXB2, produced in Escherichia coli648143--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
malfunctionHuman immunodeficiency virus 1-inactivation of HIV-1 protease significantly increases the protease-specific humoral immune responses in mice718440
physiological functionHuman immunodeficiency virus 1-the enzyme is required for virus replication717185

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
2-aminobenzoyl-TI-Nle-Phe(NO2)-ER + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648156--?
2-aminobenzoyl-TI-Nle-Phe(NO2)-QR + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648156--?
2-aminobenzoyl-TI-Nle-Phe(NO2)-QR-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1-the enzyme reacts with the substrate to give an initial enzyme-substrate complex that isomerizes to a kinetically competent intermediate EX648151--?
4-(4-(dimethylamino)phenylazo)benzoyl-SQNYPIVQ-5-((2-aminoethyl)amino)naphthalene-1-sulfonic acid + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648150--?
Abz-Ala-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--699555--?
Abz-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--699555--?
Abz-KARV-Nle-Phe(NO2)-EA-Nle-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648150--?
Abz-Lys-Ala-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--699555--?
Abz-Thr-Ile-Nle-(p-nitro)Phe-Gln-Arg-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--699546, 699555--?
Abz-Thr-Ile-Nle-4-nitro-Phe-Gln-Arg-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1-the fluorogenic peptide substrate664605--?
Abz-Thr-Ile-Nle-Phe(NO2)-Gln-Arg + H2O?
show the reaction diagram		Human immunodeficiency virus 1--709467--?
Abz-TI-Nle-Phe(NO2)-QR-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648152--?
Ac-ARALAE-NH2 + H2OAc-ARAL + AE-NH2
show the reaction diagram		Human immunodeficiency virus 1--648122-648122?
Ac-ATIMMQR-NH2 + H2OAc-ATIM + MQR-NH2
show the reaction diagram		Human immunodeficiency virus 1--648122-648122?
Ac-HGWILAEHGD-NH2 + H2OAc-HGWIL + AEHGD-NH2
show the reaction diagram		Human immunodeficiency virus 1--648124-648124?
Ac-KASQ(p-nitrophenylalanine)PPV-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648122--?
Ac-RASQNYPVV-NH2 + H2OAc-RASQNY + PVV-NH2
show the reaction diagram		Human immunodeficiency virus 1--648124-648124?
Ac-RKILFLDG-NH2 + H2OAc-RKIL + FLDG-NH2
show the reaction diagram		Human immunodeficiency virus 1--648124-648124?
Ac-SQNYFLDG-NH2 + H2OAc-SQNY + FLDG-NH2
show the reaction diagram		Human immunodeficiency virus 1--648124-648124?
Ac-SQNYPIV-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648140--?
Ac-SQNYPVV-NH2 + H2OAc-SQNY + PVV-NH2
show the reaction diagram		Human immunodeficiency virus 1--648124-648124?
Ac-SQNYPVVR + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648126--?
Ac-SQSYPVV-NH2 + H2OAc-SQSY + PVV-NH2
show the reaction diagram		Human immunodeficiency virus 1--648124-648124?
Ac-TIMMQR-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648120--?
Ac-VSQNYPIV-NH2 + H2OAc-VSQNY + PIV-NH2
show the reaction diagram		Human immunodeficiency virus 1--648122-648122?
Ac-YRARVFFVRAAK-biotin + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648122--?
AETFYVDG + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648127--?
AETFYVDGAA + H2OAETF + YVDGAA
show the reaction diagram		Human immunodeficiency virus 1P03367-648164---
AETFYVDGAA + H2OAETF + YVDGAA
show the reaction diagram		Human immunodeficiency virus 1--682522--?
aminobenzoyl-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--707444--?
Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln Lys-(DABCYL)-Arg + H2O?
show the reaction diagram		Human immunodeficiency virus 1--717971--?
Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-Arg + H2O?
show the reaction diagram		Human immunodeficiency virus 1--707682, 707721--?
Arg-Glu-[5-[(2'-aminoethyl)-amino]naphthalenesulfonyl]-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-[4-[[4'-(dimethylamino)phenyl]azo]-benzoyl]-Arg + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648159--?
Arg-Pro-Gly-Asn-Phe-Leu-Gln-Ser-Arg-Pro + H2O?
show the reaction diagram		Human immunodeficiency virus 1Q90VT5decameric p1-p6 peptide699902--?
ARVLAEAM + H2OARVL + AEAM
show the reaction diagram		Human immunodeficiency virus 1--648127-648127?
ARVLAEAM + H2OARVL + AEAM
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
ATHDVY-Phe(NO2)-VRKA + H2OATHDVY + Phe(NO2)-VRKA
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
ATHNVY-Phe(NO2)-VRKA + H2OATHNVY + Phe(NO2)-VRKA
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
ATHQVY-Phe(NO2)-VRKA + H2OATHQVY + Phe(NO2)-VRKA
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
ATHRVY-Phe(NO2)-VRKA + H2OATHRVY + Phe(NO2)-VRKA
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
ATHVVY-Phe(NO2)-VRKA + H2OATHVVY + Phe(NO2)-VRKA
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
ATHYVY-Phe(NO2)-VRKA + H2OATHYVY + Phe(NO2)-VRKA
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
ATIMMQRG + H2OATIM + MQRG
show the reaction diagram		Human immunodeficiency virus 1--648127-648127?
B-chain of oxidized insulin + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648130--?
beta-secretase + H2Otruncated beta-secretase protein + peptide E25-F39
show the reaction diagram		Human immunodeficiency virus 1-expression of beta-secretase in mammalian host cells leads to full-length pro-form and the processed enzyme missing the first 24 amino acids and beginning with residue E25. Protease treatment of the mixture results in complete cleavage of the F39-V40 bond701086--?
beta-secretase precursor protein + H2Otruncated beta-secretase protein + peptide T1-F39
show the reaction diagram		Human immunodeficiency virus 1-expression of beta-secretase in mammalian host cells leads to full-length pro-form and the processed enzyme missing the first 24 amino acids and beginning with residue E25. Protease treatment of the mixture results in complete cleavage of the F39-V40 bond701086--?
capsid-p2 protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--717998--?
CTLNFPISP + H2OCTLNF + PISP
show the reaction diagram		Human immunodeficiency virus 1P03367-648164--?
DABCYL-(gamma-Abu)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS + H2O?
show the reaction diagram		Human immunodeficiency virus 1--709481--?
DTV(I)33EEMS + H2ODTV(I)33 + EEMS
show the reaction diagram		Human immunodeficiency virus 1--648136-648136?
DTV(L)33EEMS + H2ODTV(L)33 + EEMS
show the reaction diagram		Human immunodeficiency virus 1--648136-648136?
DTV(V)33EEMS + H2ODTV(V)33 + EEMS
show the reaction diagram		Human immunodeficiency virus 1--648136-648136?
DTV(V)33EKMS + H2ODTV(V)33 + EKMS
show the reaction diagram		Human immunodeficiency virus 1--648136-648136?
GAETFYVDGAA + H2OGAETF + YVDGAA
show the reaction diagram		Human immunodeficiency virus 1--648142-648142?
Gag polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--666063, 717302, 717998, 718075, 718373--?
Gag polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1Q7SSE3-718370--?
Gag polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-substrate sites, overview666884--?
Gag polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-CA/p2 cleavage site is KARVL*AEAMS666063--?
Gag precursor protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-five different cleavage sites, the p2-NC-site is the first, the CA/p2 the last one in sequential processing of the precursor664895--?
Gag protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-proteolytic cleavage in the host cell cytoplasm, site-specific proteolytic cleavage of the protein precursor662382--?
Gag-Pol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--666063, 717185, 717302, 717709, 717998, 718075, 718373--?
Gag-Pol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1Q7SSE3-718370--?
Gag-Pol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-proteolytic cleavage in the host cell cytoplasm662382--?
Gag-Pol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-NC/p1 cleavage site is ERQAN*FLGKI666063--?
Gag-Pol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-site-specific proteolytic cleavage of the protein precursor662382--?
GagPol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--664137--?
H-Lys-Ala-Arg-Val-Tyr-Phe(4-NO2)-Glu-Ala-Nle-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--678616--?
His-Lys-Ala-Arg-Val-Leu-(p-nitro)-Phe-Glu-Ala-Nle-Ser-amide + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648134--?
His-Lys-Ala-Arg-Val-Leu-(p-NO2-Phe)-Glu-Ala-Nle-Ser-NH2 + H2OHis-Lys-Ala-Arg-Val-Leu + (p-NO2-Phe)-Glu-Ala-Nle-Ser-NH2
show the reaction diagram		Human immunodeficiency virus 1--709592--?
His-Lys-Ala-Arg-Val-Leu-(pNO2-Phe)-Glu-Ala-Ile-Ser-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--707180--?
His-Lys-Ala-Arg-Val-Leu-(pNO2-Phe)-Glu-Ala-Nle-Ser-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--678626--?
HIV-1 Gag-Pol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-site-specific proteolytic cleavage, protein precursors and peptides derived thereof665102--?
HIV-2 Gag-Pol poylprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-site-specific proteolytic cleavage, protein precursors and peptides derived thereof665102--?
HKARVLAEAMS + H2OHKARVL + AEAMS
show the reaction diagram		Human immunodeficiency virus 1--648142-648142?
IPFAAAQQRK + H2OIPFAA + AQQRK
show the reaction diagram		Human immunodeficiency virus 1Q7SSE3the protein contains a HIV-2 cleavage site718370--?
IRKILFLDG + H2OIRKIL + FLDG
show the reaction diagram		Human immunodeficiency virus 1P03367-648164--?
KAQNYPIA-Nle + H2OKAQNY + PIA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KAQNYPIV-Nle + H2OKAQNY + PIV-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARA-Nle-Phe(NO2)-EA-Nle + H2OKARA-Nle + Phe(NO2)-EA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARI-Nle-Phe(NO2)-EA-Nle + H2OKARI-Nle + Phe(NO2)-EA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARL-Nle-Phe(NO2)-EA-Nle + H2OKARL-Nle + Phe(NO2)-EA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARLMAEALK + H2OKARLM + AEALK
show the reaction diagram		Human immunodeficiency virus 1Q7SSE3the protein contains a HIV-2 cleavage site718370--?
KARN-Nle-Phe(NO2)-EA-Nle + H2OKARN-Nle + Phe(NO2)-EA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARNYPA-Nle + H2OKARNY + PA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARNYPE-Nle + H2OKARNY + PE-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARNYPI-Nle + H2OKARNY + PI-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARNYPN-Nle + H2OKARNY + PN-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARNYPQ-Nle + H2OKARNY + PQ-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARNYPV-Nle + H2OKARNY + PV-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARV-Nle-Phe(NO2)-AA-Nle + H2OKARV-Nle + Phe(NO2)-AA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARV-Nle-Phe(NO2)-EA-Nle + H2OKARV-Nle + Phe(NO2)-EA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648153---
KARV-Nle-Phe(NO2)-EA-Nle + H2OKARV-Nle + Phe(NO2)-EA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARV-Nle-Phe(NO2)-EA-Nle-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648141, 648153, 648159--?
KARV-Nle-Phe(NO2)-EA-Nle-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1P03367-648164--?
KARV-Nle-Phe(NO2)-EA-Nle-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1P04585-648165--?
KARV-Nle-Phe(NO2)-EA-Nle-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648169--?
KARV-Nle-Phe(NO2)-IA-Nle + H2OKARV-Nle + Phe(NO2)-IA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARV-Nle-Phe(NO2)-NA-Nle + H2OKARV-Nle + Phe(NO2)-NA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARV-Nle-Phe(NO2)-QA-Nle + H2OKARV-Nle + Phe(NO2)-QA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARV-Nle-Phe(NO2)-TA-Nle + H2OKARV-Nle + Phe(NO2)-TA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARV-Nle-Phe(NO2)-VA-Nle + H2OKARV-Nle + Phe(NO2)-VA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARVL-Phe(NO2)-EAM + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648142--?
KARVLAEAMS + H2OKARVL + AEAMS
show the reaction diagram		Human immunodeficiency virus 1--648153-648153?
KARVLAEAMS + H2OKARVL + AEAMS
show the reaction diagram		Human immunodeficiency virus 1P03367-648164--?
KARVLAEAMS + H2OKARVL + AEAMS
show the reaction diagram		Human immunodeficiency virus 1--648166--?
KARVMPhe(NO2)-EA-Nle + H2OKARVM + Phe(NO2)-EA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KARVYPhe(NO2)-EA-Nle + H2OKARVY + Phe(NO2)-EA-Nle
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
KGRPGNFLQSRP + H2OKGRPGNF + LQSRP
show the reaction diagram		Human immunodeficiency virus 1--648148-648148?
KLRPGNFLQSRP + H2OKLRPGNF + LQSRP
show the reaction diagram		Human immunodeficiency virus 1--648148---
KLRPGNFLQSRP + H2OKLRPGNF + LQSRP
show the reaction diagram		Human immunodeficiency virus 1--648142-648142?
Lys-Ala-Arg-Val-Leu-4-nitro-Phe-Glu-Ala-Nle-Gly + H2OLys-Ala-Arg-Val-Leu + 4-nitro-Phe-Glu-Ala-Nle-Gly
show the reaction diagram		Human immunodeficiency virus 1-i.e. substrate L6525, the peptide substrate contains the CA-p2 cleavage site664895--?
Lys-Ala-Arg-Val-Leu-4-nitro-Phe-Glu-Ala-Nle-Gly + H2OLys-Ala-Arg-Val-Leu + 4-nitro-Phe-Glu-Ala-Nle-Gly
show the reaction diagram		Human immunodeficiency virus 1-the peptide substrate mimicks the CA-p2 cleavage site664013--?
Lys-Ala-Arg-Val-Leu-Ala-Glu-Ala-Met + H2O?
show the reaction diagram		Human immunodeficiency virus 1-in the protease-substrate complex the highest fluctuations correspond to the 17- and 39-turns and the substrate motion is anticorrelated with the 39-turn. The active site residues and the flap tips move in phase with the peptide678731--?
Lys-Ala-Arg-Val-Leu-Phe(NO2)-Glu-Ala-Met + H2O?
show the reaction diagram		Human immunodeficiency virus 1--718075--?
Lys-Ala-Arg-Val-Nle-(4-nitrophenylalanine)-Glu-Ala-Nle-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--680778, 718373--?
Lys-Ala-Arg-Val-Nle-(p-nitro-Phe)-Glu-Ala-Nle-amide + H2O?
show the reaction diagram		Human immunodeficiency virus 1--710216--?
Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amide + H2OLys-Ala-Arg-Val-Nle + 4-nitro-Phe-Glu-Ala-Nle-amide
show the reaction diagram		Human immunodeficiency virus 1-the peptide substrate mimicks the CA-p2 cleavage site666016--?
Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amide + H2OLys-Ala-Arg-Val-Nle + 4-nitro-Phe-Glu-Ala-Nle-amide
show the reaction diagram		Human immunodeficiency virus 1-the peptide substrate mimicks the HIV-1 CA/p2 cleavage site666063--?
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly + H2OLys-Ala-Arg-Val-Nle + Phe(4-NO2)-Glu-Ala-Nle-Gly
show the reaction diagram		Human immunodeficiency virus 1--678346--?
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2 + H2OLys-Ala-Arg-Val-Nle + Phe(4-NO2)-Glu-Ala-Nle-NH2
show the reaction diagram		Human immunodeficiency virus 1--681460--?
Lys-Ala-Arg-Val-Tyr-p-nitro-Phe-Glu-Ala-Ile-NH2 + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648131--?
matrix-capsid protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--717998--?
N-dansyl-SQNYPIV + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648122--?
nucleocapsid protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-characterization of human immunodeficiency virus type 1 containing mutations in the nucleocapsid protein at a putative HIV-1 protease cleavage site682973--?
nucleocapsid-p1 protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--717998--?
p1-p6 protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--717998--?
p2-nucleocapsid protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--717998--?
PAFVLAEAMR + H2OPAFVL + AEAMR
show the reaction diagram		Human immunodeficiency virus 1--648138-648138?
PARVLAEAMR + H2OPARVL + AEAMR
show the reaction diagram		Human immunodeficiency virus 1--648138-648138?
PARVLFEAMR + H2OPARVL + FEAMR
show the reaction diagram		Human immunodeficiency virus 1--648138-648138?
PARVLIEAMR + H2OPARVL + IEAMR
show the reaction diagram		Human immunodeficiency virus 1--648138-648138?
PARVLLEAMR + H2OPARVL + LEAMR
show the reaction diagram		Human immunodeficiency virus 1--648138-648138?
PARVLMEAMR + H2OPARVL + MEAMR
show the reaction diagram		Human immunodeficiency virus 1--648138-648138?
PARVLVEAMR + H2OPARVL + VEAMR
show the reaction diagram		Human immunodeficiency virus 1--648138-648138?
PFAVSLAMTMRR + H2OPFAVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PGAVSLAMTMRR + H2OPGAVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PGNFLESR + H2OPGNF + LESR
show the reaction diagram		Human immunodeficiency virus 1--648127-648127?
PHAVSLAMTMRR + H2OPHAVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PLAVSLAMTMRR + H2OPLAVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PNAVSLAMTMRR + H2OPNAVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
Pol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-substrate sites, overview666884--?
Poly(A)-binding protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--710383--?
PPAGSLAMTMRR + H2OPPAGS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAHSLAMTMRR + H2OPPAHS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPALSLAMTMRR + H2OPPALS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPASSLAMTMRR + H2OPPASS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVALAMTMRR + H2OPPAVA + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVELAMTMRR + H2OPPAVE + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVGLAMTMRR + H2OPPAVG + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVHLAMTMRR + H2OPPAVH + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVLLAMTMRR + H2OPPAVL + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVRLAMTMRR + H2OPPAVR + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSEAMTMRR + H2OPPAVS + EAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSFAMTMRR + H2OPPAVS + FAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSGAMTMRR + H2OPPAVS + GAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSLALTMRR + H2OPPAVS + LALTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSLAMTMRR + H2OPPAVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSLAMTMRR + H2OPPAVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648138--?
PPAVSLANTMRR + H2OPPAVS + LANTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSLAYTMRR + H2OPPAVS + LAYTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSLGMTMRR + H2OPPAVS + LGMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSLHMTMRR + H2OPPAVS + LHMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSLLMTMRR + H2OPPAVS + LLMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSLSMTMRR + H2OPPAVS + LSMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSQAMTMRR + H2OPPAVS + QAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVSRAMTMRR + H2OPPAVS + RAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAVWLAMTMRR + H2OPPAVW + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPAWSLAMTMRR + H2OPPAWS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPDVSLAMTMRR + H2OPPDVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPFVSLAMTMRR + H2OPPFVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPGVSLAMTMRR + H2OPPGVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPHVSLAMTMRR + H2OPPHVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPNVSLAMTMRR + H2OPPNVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPPVSLAMTMRR + H2OPPPVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PPRVSLAMTMRR + H2OPPRVS + LAMTMRR
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
PQITLLLLLKWKRP + H2OPQITLLLLL + WKRP
show the reaction diagram		Human immunodeficiency virus 1--648136-648136?
PQITLLLLLWQRP + H2OPQITLLLLL + WQRP
show the reaction diagram		Human immunodeficiency virus 1--648136-648136?
reverse transcriptase-RNaseH protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--717998--?
REYDQI(I)63IEVS + H2OREYDQI(I)63 + IEVS
show the reaction diagram		Human immunodeficiency virus 1--648136-648136?
REYDQI(L)63IEVS + H2OREYDQI(L)63 + IEVS
show the reaction diagram		Human immunodeficiency virus 1--648136-648136?
REYDQI(L)63IKVS + H2OREYDQI(L)63 + IKVS
show the reaction diagram		Human immunodeficiency virus 1--648136-648136?
RKILFLDG + H2ORKIL + FLDG
show the reaction diagram		Human immunodeficiency virus 1--648127-648127?
RNaseH-integrase protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--717998--?
RQGTVSFNFPQITL + H2ORQGTVSFNF + PQITL
show the reaction diagram		Human immunodeficiency virus 1--648142-648142?
RQGTVSFNFPQITL + H2ORQGTVSFNF + PQITL
show the reaction diagram		Human immunodeficiency virus 1--648148, 648171--?
SANYPIV + H2OSANY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SCNYPIV + H2OSCNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SDNYPIV + H2OSDNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SENYPIV + H2OSENY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SFNFPQIT + H2OSFNF + PQIT
show the reaction diagram		Human immunodeficiency virus 1--648127-648127?
SFNYPIV + H2OSFNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SGNYPIV + H2OSGNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SHNYPIV + H2OSHNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SINYPIV + H2OSINY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SKNYPIV + H2OSKNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SLNYPIV + H2OSLNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SMNYPIV + H2OSMNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SNNYPIV + H2OSNNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQAYPIV + H2OSQAY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQCYPIV + H2OSQCY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQDYPIV + H2OSQDY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQEYPIV + H2OSQEY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNFPIV + H2OSQNF + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNLPIV + H2OSQNL + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNMPIV + H2OSQNM + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNWPIV + H2OSQNW + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNYAIV + H2OSQNY + AIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNYFIV + H2OSQNY + FIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNYIIV + H2OSQNY + IIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNYLIV + H2OSQNY + LIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNYMIV + H2OSQNY + MIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNYPAV + H2OSQNY + PAV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNYPIV + H2OSQNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNYPIV + H2OSQNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648163--?
SQNYPIVQ + H2OSQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648127-648127?
SQNYPLV + H2OSQNY + PLV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNYVIV + H2OSQNY + VIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNYWIV + H2OSQNY + WIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQNYYIV + H2OSQNY + YIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SQVYPIV + H2OSQVY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SRNYPIV + H2OSRNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SSNYPIV + H2OSSNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
STNYPIV + H2OSTNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SWNYPIV + H2OSWNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
SYNYPIV + H2OSYNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
TATIMMQRGN + H2OTATIM + MQRGN
show the reaction diagram		Human immunodeficiency virus 1--648142-648142?
TATIMMQRGN + H2OTATIM + MQRGN
show the reaction diagram		Human immunodeficiency virus 1--648171--?
TFQA(p-nitrophenylalanine)PLREA + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648122--?
TLNFPISP + H2OTLNF + PISP
show the reaction diagram		Human immunodeficiency virus 1--648127-648127?
TLNFPISPKK + H2OTLNF + PISPKK
show the reaction diagram		Human immunodeficiency virus 1--648153--?
translation initiation factor eIF4GI + H2O?
show the reaction diagram		Human immunodeficiency virus 1--710383--?
Val-Ser-Gln-Ala-Tyr-Pro-Ile-Val-Gln + H2OVal-Ser-Gln-Ala-Tyr + Pro-Ile-Val-Gln
show the reaction diagram		Human immunodeficiency virus 1P04587-666190--?
Val-Ser-Gln-Asn-(2-naphthylalanine)-Pro-Ile-Val + H2O?
show the reaction diagram		Human immunodeficiency virus 1--717976--?
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln + H2OVal-Ser-Gln-Asn-Tyr + Pro-Ile-Val-Gln
show the reaction diagram		Human immunodeficiency virus 1P04587-666190--?
Val-Ser-Gln-Cys-Tyr-Pro-Ile-Val-Gln + H2OVal-Ser-Gln-Cys-Tyr + Pro-Ile-Val-Gln
show the reaction diagram		Human immunodeficiency virus 1P04587-666190--?
Val-Ser-Gln-Gly-Tyr-Pro-Ile-Val-Gln + H2OVal-Ser-Gln-Gly-Tyr + Pro-Ile-Val-Gln
show the reaction diagram		Human immunodeficiency virus 1P04587-666190--?
Val-Ser-Gln-Ile-Tyr-Pro-Ile-Val-Gln + H2OVal-Ser-Gln-Ile-Tyr + Pro-Ile-Val-Gln
show the reaction diagram		Human immunodeficiency virus 1P04587-666190--?
Val-Ser-Gln-Leu-Tyr-Pro-Ile-Val-Gln + H2OVal-Ser-Gln-Leu-Tyr + Pro-Ile-Val-Gln
show the reaction diagram		Human immunodeficiency virus 1P04587-666190--?
Val-Ser-Gln-Phe-Tyr-Pro-Ile-Val-Gln + H2OVal-Ser-Gln-Phe-Tyr + Pro-Ile-Val-Gln
show the reaction diagram		Human immunodeficiency virus 1P04587-666190--?
Val-Ser-Gln-Thr-Tyr-Pro-Ile-Val-Gln + H2OVal-Ser-Gln-Thr-Tyr + Pro-Ile-Val-Gln
show the reaction diagram		Human immunodeficiency virus 1P04587-666190--?
Val-Ser-Gln-Val-Tyr-Pro-Ile-Val-Gln + H2OVal-Ser-Gln-Val-Tyr + Pro-Ile-Val-Gln
show the reaction diagram		Human immunodeficiency virus 1P04587-666190--?
VAQNYPIVQ + H2OVAQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VDQNYPIVQ + H2OVDQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VFQNYPIVQ + H2OVFQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VGQNYPIVQ + H2OVGQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VIQNYPIVQ + H2OVIQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VKQNYPIVQ + H2OVKQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VLQNYPIVQ + H2OVLQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VLQNYPIVQ + H2OVLQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1Q7SSE3the protein contains a HIV-1 cleavage site718370--?
VMQNYPIVQ + H2OVMQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VNQNYPIVQ + H2OVNQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VPQNYPIVQ + H2OVPQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VRQNYPIVQ + H2OVRQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VSFNFPQITKK + H2OVSFNF + PQITKK
show the reaction diagram		Human immunodeficiency virus 1--648153-648153?
VSFNFPQITL + H2OVSFNF + PQITL
show the reaction diagram		Human immunodeficiency virus 1P03367-648164-648164?
VSQLYPIVQ + H2OVSQLY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1Q7SSE3the protein contains a HIV-1 cleavage site718370--?
VSQNYPIDQ + H2OVSQNY + PIDQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VSQNYPIV + H2OVSQNY + PIV
show the reaction diagram		Human immunodeficiency virus 1--648136-648136?
VSQNYPIVQ + H2OVSQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VSQNYPIVQ + H2OVSQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648142--?
VSQNYPIVQ + H2OVSQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648148-648148?
VSQVYPIVQ + H2OVSQVY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1Q7SSE3the protein contains a HIV-1 cleavage site718370--?
VTQNYPIVQ + H2OVTQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VVQNYPIVQ + H2OVVQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1--648137-648137?
VVQNYPIVQ + H2OVVQNY + PIVQ
show the reaction diagram		Human immunodeficiency virus 1Q7SSE3the protein contains a HIV-1 cleavage site718370--?
YVSQNFPIVQNR + H2OYVSQNF + PIVQNR
show the reaction diagram		Human immunodeficiency virus 1-synthetic peptide substrate based on the Ma/Ca cleavage site of HIV-1 Gag665102--?
eIF4GI + H2O?
show the reaction diagram		Human immunodeficiency virus 1-perhaps cleavage of eIF4G is an event that contributes to a more efficient translation of the genomic HIV-1 mRNA, proteolysis of eIF4GI inhibits protein synthesis directed by capped mRNAs but allows internal ribosome entry site-driven translation, purified enzyme cleaves at positions 678-679, 681-682 and 1086-1087, separating the three domains of the initiation factor648170--?
elF4GI + H2Oadditional information-Human immunodeficiency virus 1-purified enzyme cleaves at positions 678-679, 681-682 and 1086-1087, separating the three domains of the initiation factor648170--?
Moloney murine sarcoma virus-derived gag protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--648130--?
additional information?-Human immunodeficiency virus 1-insertion of human immunodeficiency virus type 1 protease substrate sequences into the permissive sites converts thymidylate synthase to an HIV-1 protease substrate648161---
additional information?-Human immunodeficiency virus 1-replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease648168---
additional information?-Human immunodeficiency virus 1-autocatalytic maturation, two temporally regulated N-terminal cleavages, first at the native TFP/p6pol followed by cleavage at the p6pol/PR, are crucial for protease maturation and enzymatic activity648159---
additional information?-Human immunodeficiency virus 1-the enzyme exhibits autoprocessing648134---
additional information?-Human immunodeficiency virus 1-artificial neural network method for predicting HIV protease cleavage sites in protein648155---
additional information?-Human immunodeficiency virus 1-sequences surrounding HIV-1 protease cleavage sites in several viral and nonviral protein substrates. No amino acid is required at any of the eight positions of the substrate. The highest preference is seen for glutamate at P2' followed by Phe at P1648127---
additional information?-Human immunodeficiency virus 1-the cleavage site involves a Phe or Tyr as the N-terminal P1 side and a Pro as the C-terminal P1' side of the scissile bond648128---
additional information?-Human immunodeficiency virus 1-the minimum length of effective HIV-1 protease substrate is seven amino acid residues648121---
additional information?-Human immunodeficiency virus 1-autoprocessing of the mature protease from the precursor can either occur in two steps at pH values of 4 to 6 or in a single step above pH 6648169---
additional information?-Human immunodeficiency virus 1-the enzyme plays an essential role in the late-stage maturation step of the virus replication cycle. HIV-1 proteinase autocatalyzes its own cleavage from the Pr165 polyprotein precursor and then cleaves both polyproteins at other specific sites to produce mature proteins648132---
additional information?-Human immunodeficiency virus 1-regulation of the protease in the viral life cycle: transframe region flanking the N-terminus of the protease may function as a negative regulator for protein folding and dimerization. The low dimer stability of the protease precursor relative to that of the mature enzyme is an ideal way of preventing the emergence of enzymatic functions until assembly of the viral particle is complete648169---
additional information?-Human immunodeficiency virus 1-the enzyme is responsible for the processing of gag and gag-pol polyprotein precursors to produce structural proteins and enzymes for the mature virus648147---
additional information?-Human immunodeficiency virus 1-the enzyme facilitates viral maturation by cleaving ten asymmetric and nonhomologous sequences in the Gag and Pol polyproteins648157---
additional information?-Human immunodeficiency virus 1-the enzyme is essential for the replication of the virus648134---
additional information?-Human immunodeficiency virus 1-the enzyme is involved in regulation of the incorporation of reverse transcriptase in the viral early assembly complex comprising reverse transcriptase, genomic RNA, Gag, Gag-Pol, tRNALys, and lysyl tRNA synthetase, HIV-1 protease activity is negatively regulated by the lysyl tRNA synthetase662382---
additional information?-Human immunodeficiency virus 1P04587amino acid preferences for the critical P2' substrate binding subsite in type 1 cleavage sites, molecular modeling and phylogenetic comparison, overview666190---
additional information?-Human immunodeficiency virus 1-molecular basis for substrate recognition and drug resistance664895---
additional information?-Human immunodeficiency virus 1-substrate and cleavage site sequence specificity, overview, drug resistance occasionally confers a change in substrate specificity, prediction of substrate specificity by three-dimensional structure analysis, detailed overview666884---
additional information?-Human immunodeficiency virus 1-substrate specificity and kinetics of wild-type and mutant enzymes, overview666063---
additional information?-Human immunodeficiency virus 1-comparison of protease specificities for P1, P3, P4 cleaving positions of proteases of HIV-1, HIV-2, equine infectious anemia virus, avian myeloblastosis virus, Mason-Pfizer monkey virus, mouse mammary tumor virus, Moloney murine leukemia virus, human T-lymphotropic virus type 1, bovine leukemia virus, walleye dermal sarcoma virus, and human foamy virus. The retroviral proteases have similar preferences for Phe and Tyr for the P1 position in this sequence context. The sizes of the P3 and P4 residues appear to be a major contributor for specificity693905---
additional information?-Human immunodeficiency virus 1-Arg-Val-Leu-Ala-Glu-Ala-Met mimics the real substrate707528---

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
eIF4GI + H2O?
show the reaction diagram		Human immunodeficiency virus 1-perhaps cleavage of eIF4G is an event that contributes to a more efficient translation of the genomic HIV-1 mRNA, proteolysis of eIF4GI inhibits protein synthesis directed by capped mRNAs but allows internal ribosome entry site-driven translation, purified enzyme cleaves at positions 678-679, 681-682 and 1086-1087, separating the three domains of the initiation factor648170--
Gag polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--666063, 717302, 717998, 718075, 718373--
Gag polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1Q7SSE3-718370--
Gag polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-substrate sites, overview666884--
Gag protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-proteolytic cleavage in the host cell cytoplasm662382--
Gag-Pol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--666063, 717185, 717302, 717709, 717998, 718075, 718373--
Gag-Pol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1Q7SSE3-718370--
Gag-Pol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-proteolytic cleavage in the host cell cytoplasm662382--
nucleocapsid protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--682973--
Pol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1-substrate sites, overview666884--
Poly(A)-binding protein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--710383--
translation initiation factor eIF4GI + H2O?
show the reaction diagram		Human immunodeficiency virus 1--710383--
GagPol polyprotein + H2O?
show the reaction diagram		Human immunodeficiency virus 1--664137--
additional information?-Human immunodeficiency virus 1-the enzyme plays an essential role in the late-stage maturation step of the virus replication cycle. HIV-1 proteinase autocatalyzes its own cleavage from the Pr165 polyprotein precursor and then cleaves both polyproteins at other specific sites to produce mature proteins648132--
additional information?-Human immunodeficiency virus 1-regulation of the protease in the viral life cycle: transframe region flanking the N-terminus of the protease may function as a negative regulator for protein folding and dimerization. The low dimer stability of the protease precursor relative to that of the mature enzyme is an ideal way of preventing the emergence of enzymatic functions until assembly of the viral particle is complete648169--
additional information?-Human immunodeficiency virus 1-the enzyme is responsible for the processing of gag and gag-pol polyprotein precursors to produce structural proteins and enzymes for the mature virus648147--
additional information?-Human immunodeficiency virus 1-the enzyme facilitates viral maturation by cleaving ten asymmetric and nonhomologous sequences in the Gag and Pol polyproteins648157--
additional information?-Human immunodeficiency virus 1-the enzyme is essential for the replication of the virus648134--
additional information?-Human immunodeficiency virus 1-the enzyme is involved in regulation of the incorporation of reverse transcriptase in the viral early assembly complex comprising reverse transcriptase, genomic RNA, Gag, Gag-Pol, tRNALys, and lysyl tRNA synthetase, HIV-1 protease activity is negatively regulated by the lysyl tRNA synthetase662382--
additional information?-Human immunodeficiency virus 1-Arg-Val-Leu-Ala-Glu-Ala-Met mimics the real substrate707528--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
No entries in this field

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
Na+Human immunodeficiency virus 1-role of Na+ ions in stabilizing the active site666873
NaClHuman immunodeficiency virus 1-the protease works more efficiently at high salt concentrations, 2 M NaCl, than at lower salt concentrations648137
Ca2+Human immunodeficiency virus 1-dependent on717185
additional informationHuman immunodeficiency virus 1-the activity of the enzyme is dependent on the ionic strength of the reaction mixture, rather than on the binding of a specific ion to an enzymatic site648124

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
((S)-1-(N'-(3',5'-difluoro-biphenyl-4-ylmethyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxyindan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1--709481-
((S)-1-(N'-(4'-acetylamino-biphenyl-4-ylmethyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethylpropyl)-carbamic acid methyl esterHuman immunodeficiency virus 1--709481-
((S)-1-(N'-(4-benzo[1,3]dioxol-5-yl-benzyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxyindan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1--709481-
((S)-1-(N'-benzyl-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1--709481-
((S)-1-(N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-phenethyl-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1--709481-
((S)-1-(N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-[4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1--709481-
((S)-1-(N'-[4-(3,5-dimethyl-isoxazol-4-yl)-benzyl]-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethylpropyl)-carbamic acid methyl esterHuman immunodeficiency virus 1--709481-
((S)-1-[N'-(4-bromo-benzyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1--709481-
((S)-1-[N'-biphenyl-4-ylmethyl-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1--709481-
((S)-1-[N'-[(S)-3-Hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1--709481-
((S)-1-[N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-(4-pyridin-3-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1--709481-
((S)-1-[N'-[(S)-3-Hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-(4-pyridin-4-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1--709481-
(1-Benzyl-3-benzylcarbamoyl-3,3-difluoro-2-oxo-propyl)-carbamic acid benzyl esterHuman immunodeficiency virus 1--648128 2D-image
(1S)-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-1-(1-[(2S)-1-[(2-ammonioethyl)amino]-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl)-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethanamiHuman immunodeficiency virus 1--707682-
(1S)-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethanaminiumHuman immunodeficiency virus 1--707682-
(1S)-2-methyl-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-2-methyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]propan-1-amineHuman immunodeficiency virus 1--707682-
(1S)-2-methyl-1-[1-[(1S)-2-methyl-1-[1-[(1S)-1-[1-[(1S)-2-methyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]propan-1-amineHuman immunodeficiency virus 1--707682-
(1S)-2-methyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]propan-1-aminiumHuman immunodeficiency virus 1--707682-
(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethanaminiumHuman immunodeficiency virus 1--707682-
(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethanamineHuman immunodeficiency virus 1--707682-
(2E)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]propyl]-4,4,4-trifluoro-3-methylbut-2-enamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
(2E)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]propyl]-4-oxopent-2-enamideHuman immunodeficiency virus 1--680381 2D-image
(2E)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(5-methylisoxazol-4-yl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-4,4,4-trifluoro-3-methylbut-2-enamideHuman immunodeficiency virus 1--680381 2D-image
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamideHuman immunodeficiency virus 1--681109 2D-image
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R,5S)-2-hydroxy-5-methylcyclopentyl]amino]-5-oxopentyl]-N-tert-butyl-4-(3-pyridin-3-ylpropanoyl)piperazine-2-carboxamideHuman immunodeficiency virus 1--681109 2D-image
(2S)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1--680381 2D-image
(2S)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1--680381 2D-image
(2S)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1--680381 2D-image
(2S)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1--680381 2D-image
(2S)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]-2,3-dimethylbutanamideHuman immunodeficiency virus 1--680381 2D-image
(2S)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
(2S)-N-[(1S,2R,3S,4S)-1-benzyl-2,3-dihydroxy-4-[[(2S)-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanoyl]amino]-5-phenylpentyl]-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamideHuman immunodeficiency virus 1--681109 2D-image
(2S)-N-[(1S,2S,4S)-1-benzyl-2-hydroxy-4-[[(2S)-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanoyl]amino]-5-phenylpentyl]-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamideHuman immunodeficiency virus 1--681109 2D-image
(2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1--709749-
(2S)-N-[(4S,7S,10S,11R,12R,13S)-10-benzyl-11,12-dihydroxy-4-(naphthalen-1-ylmethyl)-2,2-dioxido-5,8-dioxo-14-phenyl-7-(propan-2-yl)-2l6-thia-3,6,9-triazatetradecan-13-yl]-3-methyl-2-[[(2S)-2-[(methylsulfonyl)amino]-3-(naphthalen-1-yl)propanoyl]amino]butanHuman immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2R,3R)-2,3-dihydroxybutane-1,4-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-1,6-bis(1,3-benzodioxol-5-yl)-3,4-dihydroxyhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-1,6-bis(2,4-dimethoxyphenyl)-3,4-dihydroxyhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-bis(4-hydroxyphenyl)hexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-2-hydroxy-3-phenylpropanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(4-methoxybenzyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3,3-dimethylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]pentanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(pyridin-4-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[3-(tert-butylsulfonyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[(naphthalen-1-yloxy)acetyl]amino]butanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[3-(pyridin-4-ylsulfonyl)propanoyl]amino]butanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide)Human immunodeficiency virus 1--681109, 708383 2D-image
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis[2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-(1H-imidazol-4-yl)propanamide]Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(2S,3S,4S,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide)Human immunodeficiency virus 1--681109 2D-image
(2S,2'S)-N,N'-[(3S,4R,5R,6S)-4,5-dihydroxy-1,8-di(pyridin-4-yl)octane-3,6-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(3S,4R,5R,6S)-4,5-dihydroxy-1,8-diphenyloctane-3,6-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N,N'-[(6S,7R,8R,9S)-7,8-dihydroxytetradecane-6,9-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
(2S,2'S)-N1,N1'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]butanediamide)Human immunodeficiency virus 1--708383-
(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-dicyclohexylhexane-3,4-diolHuman immunodeficiency virus 1-compound has an improved response to V82A mutant enzyme681326 2D-image
(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-diphenylhexane-3,4-diolHuman immunodeficiency virus 1--681326 2D-image
(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-6-cyclohexyl-1-phenylhexane-3,4-diolHuman immunodeficiency virus 1-compound has an improved response to V82A mutant enzyme681326 2D-image
(2S,4S)-2-[(1R)-2-(benzylamino)-2-oxo-1-[(phenylacetyl)amino]ethyl]-N-[(1S)-1-hydroxy-2-phenylethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--681109 2D-image
(2S,4S)-N-[(1R,2R)-4-[(1H-benzimidazol-2-ylmethyl)amino]-1-benzyl-2-hydroxy-4-oxobutyl]-2-[(1R)-1-(benzylcarbamoyl)-3-oxo-4-phenylbutyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--681109 2D-image
(2Z)-4,4,4-trifluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-3-methylbut-2-enamideHuman immunodeficiency virus 1--709749-
(3aR,4R,7aS)-hexahydro-2H-furo[2,3-b]pyran-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamateHuman immunodeficiency virus 1--717975-
(3aR,4S,7aR)-octahydro-1H-inden-4-yl-(2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1--717975-
(3aR,4S,7aR)-octahydrobenzofuran-4-yl (2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1--717975-
(3aR,5r,6aS)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
(3aS,4S,7aR)-hexahydro-2H-furo[2,3-b]pyran-4-yl (2S,3R)-3-hydroxy-4-(4-(hydroxymethyl)-N-isobutylphenylsulfonamido)-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1--717975-
(3aS,4S,7aR)-hexahydro-2H-furo[2,3-b]pyran-4-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1--717975-
(3aS,4S,7aR)-hexahydro-2H-furo[2,3-b]pyran-4-yl-(2S,3R)-4-(N-isobutyl-4-methoxyphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1--717975-
(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((R)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl-(2S,3R)-4-(4-amino-N-(((R)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl-(2S,3R)-4-(4-amino-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
(3aS,5R,7aR)-hexahydro-2H-furo[2,3-b]pyran-5-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamateHuman immunodeficiency virus 1--717975-
(3R)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]-3-hydroxypentanamideHuman immunodeficiency virus 1--680381 2D-image
(3R)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]-3-hydroxypentanamideHuman immunodeficiency virus 1--680381 2D-image
(3R)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]-3-hydroxypentanamideHuman immunodeficiency virus 1--680381 2D-image
(3R)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(5-methylisoxazol-4-yl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-3-methylpent-4-enamideHuman immunodeficiency virus 1--680381 2D-image
(3R)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]-3-hydroxypentanamideHuman immunodeficiency virus 1--680381 2D-image
(3R)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]-3-hydroxypentanamideHuman immunodeficiency virus 1--680381 2D-image
(3R)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]-3-hydroxypentanamideHuman immunodeficiency virus 1--680381 2D-image
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-(13-methoxy-1,1-dioxido-3,4,5,6,7,8,9,10-octahydro-2H-11,1,2-benzoxathiazacyclotridecin-2-yl)-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1-GRL-246707173-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-[(2-methylpropyl)([1-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-6-yl]sulfonyl)amino]-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707179-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-[(7Z)-12-methoxy-1,1-dioxido-4,5,6,9-tetrahydro-10,1,2-benzoxathiazacyclododecin-2(3H)-yl]-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1-GRL-396707173-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-[(7Z)-13-methoxy-1,1-dioxido-3,4,5,6,9,10-hexahydro-2H-11,1,2-benzoxathiazacyclotridecin-2-yl]-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1-GRL-216, blocks dimerization707173-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-[(7Z)-14-methoxy-1,1-dioxido-4,5,6,9,10,11-hexahydro-12,1,2-benzoxathiazacyclotetradecin-2(3H)-yl]-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1-GRL-286, blocks dimerization707173-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--709443-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3S)-3-hydroxy-4-[(4R)-4-[[4-(hydroxymethyl)-2-methylbenzyl]carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3S)-4-[(4R)-4-[(4-amino-2-methylbenzyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(2S,3R)-4-(4-amino-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((R)-2-oxooxazolidin-4-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((R)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2ylcarbamateHuman immunodeficiency virus 1--709443-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-2-oxooxazolidin-4-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-4-(4-amino-N-(((R)-2-oxooxazolidin-4-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-4-(4-amino-N-(((R)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-4-(4-amino-N-(((S)-2-oxooxazolidin-4-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
(3R,4aR,8aR)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-(phenylsulfanyl)butyl]decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--681109 2D-image
(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-(2-phenylethyl)-4-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--697298 2D-image
(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-isobutyl-3-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--697298 2D-image
(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-isobutyl-4-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--697298 2D-image
(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-propyl-4-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--697298 2D-image
(3R,4S,5S,6S)-2,7-dibenzyl-3,6-bis(phenoxymethyl)-1,2,7-thiadiazepane-4,5-diol 1,1-dioxideHuman immunodeficiency virus 1--681109 2D-image
(3R,6S,9S,10R,11R,12S,15S,18R)-3,9,12,18-tetrabenzyl-10,11-dihydroxy-4,7,14,17-tetraoxo-6,15-di(propan-2-yl)-5,8,13,16-tetraazaicosane-1,20-dioic acidHuman immunodeficiency virus 1--708383-
(3S)-tetrahydrofuran-3-yl [(2S,3R)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
(3S)-tetrahydrofuran-3-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
(3S,4aS,8aS)-2-((2R,3S)-4-(benzo[b]thiophen-2-yl)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)butyl)-N-tert-butyldecahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--709467-
(3S,4aS,8aS)-N-tert-butyl-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-3-(4-phenylthiophen-2-yl)propyl)decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--709467-
(3S,4aS,8aS)-N-tert-butyl-2-((2R,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(4-phenylthiophen-2-yl)butyl)decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--709467-
(3S,4aS,8aS)-N-tert-butyl-2-((2R,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(thiophen-2-yl)butyl)decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--709467-
(3S,4aS,8aS)-N-tert-butyl-2-((2R,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(thiophen-2-yl)proyl)decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--709467-
(3S,4S)-3-((benzyl[(2-bromo-4,5-dimethoxyphenyl)carbonyl]amino)methyl)-4-(([2-(2,4-dichlorophenyl)ethyl](4-phenylbutanoyl)amino)methyl)pyrrolidiniumHuman immunodeficiency virus 1-IC50 is 0.0198 mM, binding structure analysis, modelling664605 2D-image
(3S,4S)-3-((benzyl[(2-bromo-4,5-dimethoxyphenyl)carbonyl]amino)methyl)-4-(([2-(2,4-dichlorophenyl)ethyl][3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]amino)methyl)pyrrolidiniumHuman immunodeficiency virus 1-IC50 is 0.0221 mM, binding structure analysis, modelling664605 2D-image
(4-[4-hydroxy-2-oxo-3-[(2-phenylethyl)sulfanyl]-2H-pyran-6-yl]phenoxy)acetic acidHuman immunodeficiency virus 1--708083-
(4R)-3-[(2S,3S)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--681109 2D-image
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-L-prolinamideHuman immunodeficiency virus 1--717348-
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(2,5-dimethoxyphenyl)-L-prolinamideHuman immunodeficiency virus 1--717348-
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(2-methoxyphenyl)-L-prolinamideHuman immunodeficiency virus 1--717348-
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(3,4,5-trimethoxyphenyl)-L-prolinamideHuman immunodeficiency virus 1--717348-
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(3-methoxyphenyl)-L-prolinamideHuman immunodeficiency virus 1--717348-
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(4-methoxyphenyl)-L-prolinamideHuman immunodeficiency virus 1--717348-
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(4-methylphenyl)-L-prolinamideHuman immunodeficiency virus 1--717348-
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-phenyl-L-prolinamideHuman immunodeficiency virus 1--717348-
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-tert-butyl-L-prolinamideHuman immunodeficiency virus 1--717348-
(4R)-N-tert-butyl-3-[(2S,3S)-3-([(2,6-dimethylphenoxy)acetyl]amino)-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--681109 2D-image
(4R,5S,6S,7S)-1,3-dibenzyl-5,6-dihydroxy-4,7-bis(phenoxymethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--681109 2D-image
(4S,4aR,7aS)-octahydrocyclopenta[b]pyran-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamateHuman immunodeficiency virus 1--717975-
(4S,4aS,7aR)-hexahydro-2H-furo[3,4-b]pyran-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamateHuman immunodeficiency virus 1--717975-
(5R)-1,3-dioxepan-5-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
(5R)-4-hydroxy-5-(hydroxymethyl)-3-(13-methyltetradecanoyl)furan-2(5H)-oneHuman immunodeficiency virus 1--709660-
(5R)-4-hydroxy-5-(hydroxymethyl)-3-(14-methylhexadecanoyl)furan-2(5H)-oneHuman immunodeficiency virus 1--709660-
(5R)-4-hydroxy-5-(hydroxymethyl)-3-pentadecanoylfuran-2(5H)-oneHuman immunodeficiency virus 1--709660-
(5R)-4-hydroxy-5-(hydroxymethyl)-3-tetradecanoylfuran-2(5H)-oneHuman immunodeficiency virus 1--709660-
(5S)-3-(2,4-difluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-(2,4-difluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-(3,4-difluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--709749-
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--709749-
(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-(3-aminophenyl)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)-(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-2-oxooxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-(3-aminophenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-(3-aminophenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-(3-fluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--709749-
(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-(4-fluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-(4-fluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-[3-(acetylamino)phenyl]-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)-propyl]-2-oxooxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-[3-(acetylamino)phenyl]-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-3-[3-(acetylamino)phenyl]-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1lambda6,2-benzothiazepin-2-yl]-2-hydroxypropyl]-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717976-
(5S)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)-amino]-2-hydroxy-1-((phenylmethyl)propyl)aminocarbonyl]-2-oxo-((3-oxazolidinyl)phenyl)carbamic acid methyl esterHuman immunodeficiency virus 1--717971-
(5S)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)-amino]-2-hydroxy-1-(phenylmethyl)propyl]-3-(3-nitrophenyl)-2-oxooxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--709749-
(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-3-(2-hydroxyphenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-3-(3-nitrophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-3-[3-(methylsulfonyl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--709749-
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2,4-difluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2-hydroxyphenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(3-nitrophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(4-fluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-[3-(methylsulfonyl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2,4-difluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(3,4-difluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(3-fluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(4-fluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-[3-(methylsulfonyl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2,4-difluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2-hydroxyphenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(4-fluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1--717971-
(5S,8S,11S,12R,13R,14S,17S)-11,14-dibenzyl-17-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-8-(2-carboxyethyl)-12,13-dihydroxy-2,2-dimethyl-5-(naphthalen-1-ylmethyl)-6,9,16-trioxo-3l6-thia-7,10,15-triazaicosan-20-oic acid 3,3-dioHuman immunodeficiency virus 1--708383-
(6R)-4-hydroxy-3-[[5-methyl-2-(propan-2-yl)phenyl]sulfanyl]-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
(6S)-4-hydroxy-3-[[5-methyl-2-(propan-2-yl)phenyl]sulfanyl]-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
(hydroxyethyl)amide isostereHuman immunodeficiency virus 1--665102-
(R)-1-benzyl-3-(1-benzyl-2-oxo-ethyl)-1-piperidin-1-yl-ureaHuman immunodeficiency virus 1--707721-
(R)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(3,4-methylenedioxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
(R)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(3-methoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
(R)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(4-ethoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
(R)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(4-methoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
(R)-N-(2-methylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(3,4-methylenedioxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
(R)-N-(2-methylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(3-methoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
(R)-N-(2-methylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(4-ethoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
(R)-N-(2-methylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(4-methoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
(R)-N1-((1R,2R)-3-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2-(1H)-yl)-2-hydroxy-1-(4-phenylthiophen-2-yl)propyl)-2-(quinoline-2-carboxamido)succinamideHuman immunodeficiency virus 1--709467-
(R)-N1-((2S,3R)-1-(benzo[b]thiophen-2-yl)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxybutan-2-yl)-2-(quinoline-2-carboxamido)succinamideHuman immunodeficiency virus 1--709467-
(R)-N1-((2S,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-2-hydroxy-1-(thiophen-2-yl)propyl)-2-(quinoline-2-carboxamido)succinamideHuman immunodeficiency virus 1--709467-
(R)-N1-((2S,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(4-phenylthiophen-2-yl)butan-2-yl)-2-(quinoline-2-carboxamido)succinamideHuman immunodeficiency virus 1--709467-
(R)-N1-((2S,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(thiophen-2-yl)butan-2-yl)-2-(quinoline-2-carboxamido)succinamideHuman immunodeficiency virus 1--709467-
(S)-1-benzyl-3-(1-benzyl-2-oxo-ethyl)-1-piperidin-1-yl-ureaHuman immunodeficiency virus 1--707721-
(S)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(3-methoxyphenyl)-butanoyl]-3,3-dimethylpyrrolidine-2-carboxamideHuman immunodeficiency virus 1--678616 2D-image
(S)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(4-ethoxyphenyl)-butanoyl]-3,3-dimethylpyrrolidine-2-carboxamideHuman immunodeficiency virus 1--678616 2D-image
(S)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(4-methoxyphenyl)-butanoyl]-3,3-dimethylpyrrolidine-2-carboxamideHuman immunodeficiency virus 1--678616 2D-image
(S,2S,2'S,3R,3'R)-N,N'-((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)bis(2-((S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanamido)-3-hydroxybutanamide)Human immunodeficiency virus 1--708383-
(S,2S,2'S,3R,3'R)-N,N'-((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)bis(2-((S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanamido)-3-methylpentanamide)Human immunodeficiency virus 1--708383-
(S,S)-1-[1-benzyl-3-(1-benzyl-2-oxo-ethyl)-ureido]-pyrrolidine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1--707721-
(S,S,S,S)-1-[1-benzyl-3-(1-benzyl-2-oxo-ethyl)-ureido]-pyrrolidine-2-carboxylic acid [1-(1-tert-butylcarbamoyl-2-methyl-propylcarbamoyl)-2-methyl-butyl]-amideHuman immunodeficiency virus 1--707721-
1,3,4,7-tetrabenzyl-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
1-(4-Chloro-phenyl)-propane-1,2-dione 1-oximeHuman immunodeficiency virus 1-slightly inhibitory648140 2D-image
1-(benzyl[[(2S)-1-oxo-3-phenylpropan-2-yl]carbamoyl]amino)-L-prolyl-N-tert-butyl-L-valinamideHuman immunodeficiency virus 1--707721-
1-Chloro-3-(4-chloro-phenyl)-propan-2-oneHuman immunodeficiency virus 1-slightly inhibitory648140 2D-image
1-[(1S)-2-methyl-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-2-methyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-4-(2-phenylethyl)-1H-1,2,3-triazolHuman immunodeficiency virus 1--707682-
1-[(3R)-3-benzyl-3-([N-[(benzyloxy)carbonyl]-L-valyl]amino)-4-oxobutyl]-L-prolyl-N-tert-butyl-L-valinamideHuman immunodeficiency virus 1--707721-
1-[(3R)-3-benzyl-3-([N-[(benzyloxy)carbonyl]-L-valyl]amino)-4-oxobutyl]-N-tert-butyl-L-prolinamideHuman immunodeficiency virus 1--707721-
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-(4-oxo-4H-chromene-2-carbonyl)-piperazine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 0.13 nM648128 2D-image
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-(naphthalen-2-yloxy)-pyrrolidine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 18 nM648128 2D-image
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-(quinoline-8-sulfonyl)-piperazine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 0.03 nM648128 2D-image
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-pyridin-3-ylmethyl-piperazine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 0.41 nM648128 2D-image
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 38 nM648128 2D-image
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperidine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 80 nM648128 2D-image
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-pyrrolidine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 350 nM648128 2D-image
2'-([4-[3-(4-bromophenyl)propanoyl]phenyl]acetyl)biphenyl-2-carboxylic acidHuman immunodeficiency virus 1--708083-
2,3,4,5,5-pentahydroxy-N-[(2S,5S,8S,9R,10R,11S,14S,17S)-8,11,17-tribenzyl-9,10,20,21,22,23,23-heptahydroxy-3,6,13,16,19-pentaoxo-1-phenyl-5,14-di(propan-2-yl)-4,7,12,15,18-pentaazatricosan-2-yl]pentanamideHuman immunodeficiency virus 1--708383-
2,5-bis[[(2S)-2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-2-cyclohexylacetyl]amino]-1,2,5,6-tetradeoxy-1,6-diphenyl-L-iditolHuman immunodeficiency virus 1--708383-
2,5-bis[[(2S)-2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-2-cyclopentylacetyl]amino]-1,2,5,6-tetradeoxy-1,6-diphenyl-L-iditolHuman immunodeficiency virus 1--708383-
2,6-dimethylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetylHuman immunodeficiency virus 1-IC50: 25 nM648152 2D-image
2,6-dimethylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-2,6-dimethylphenoxyacetylHuman immunodeficiency virus 1-IC50: 28 nM648152 2D-image
2-(2,5-dichlorobenzoyl)-4,5-dihydroxybenzoic acidHuman immunodeficiency virus 1--708083-
2-(2-{5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-2,6-diphenyl-hexanoylamino}-3-methyl-butyrylamino)-3-methyl-butyric acid methyl esterHuman immunodeficiency virus 1--648125 2D-image
2-(2-{5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-2-methyl-6-phenyl-hexanoylamino}-3-methyl-butyrylamino)-3-methyl-butyric acid methyl esterHuman immunodeficiency virus 1--648125 2D-image
2-(2-{5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-6-phenyl-2-propyl-hexanoylamino}-3-methyl-butyrylamino)-3-methyl-butyric acid methyl esterHuman immunodeficiency virus 1--648125 2D-image
2-(2-{5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-6-phenyl-hexanoylamino}-3-methyl-butyrylamino)-3-methyl-butyric acid methyl esterHuman immunodeficiency virus 1--648125 2D-image
2-(3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl 5-cyclohexylpentanoateHuman immunodeficiency virus 1--708083-
2-(4-chlorophenyl)-7-hydroxyquinoline-4-carboxylic acidHuman immunodeficiency virus 1--708083-
2-hydroxy-6-pentadecylbenzoic acidHuman immunodeficiency virus 1-isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba694787 2D-image
2-hydroxy-6-[(8Z)-pentadec-8-en-1-yl]benzoic acidHuman immunodeficiency virus 1-isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba694787 2D-image
2-hydroxyphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-2-hydroxyphenoxyacetylHuman immunodeficiency virus 1-IC50: 0.009 mM648152 2D-image
2-hydroxyphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-2-hydroxyphenoxyacetylHuman immunodeficiency virus 1-IC50: 0.007 mM648152 2D-image
2-O-acetyldryopteric acid AHuman immunodeficiency virus 1-inhibitor isolated from Dryopteris crassirhizoma697300 2D-image
2-O-acetyldryopteric acid BHuman immunodeficiency virus 1-inhibitor isolated from Dryopteris crassirhizoma697300 2D-image
2-[(10Z)-heptadec-10-en-1-yl]-6-hydroxybenzoic acidHuman immunodeficiency virus 1-isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba694787 2D-image
3,3,3-Tribromo-1-(2-methoxy-phenyl)-propane-1,2-dione 1-oximeHuman immunodeficiency virus 1-highly inhibitory648140 2D-image
3,3-Dibromo-1-phenyl-propane-1,2-dione 1-oximeHuman immunodeficiency virus 1-highly inhibitory648140 2D-image
3,4-dihydroxy-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]benzamideHuman immunodeficiency virus 1--709749-
3-(2,5-diethoxyphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-most potent inhibitor718075-
3-(2,5-diethoxyphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1--718075-
3-(2,5-diethoxyphenylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1--718075-
3-(2,5-dimethylphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1--718075-
3-(2,5-dimethylphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1--718075-
3-(2,5-dimethylphenylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1--718075-
3-(2-chlorophenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1--718075-
3-(2-chlorophenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1--718075-
3-(2-chlorophenylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1--718075-
3-(2-ethylphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1--718075-
3-(2-ethylphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1--718075-
3-(2-ethylphenylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1--718075-
3-(4,8-dimethyl-3,7-nonadienyl)-(5R)-(2,5-dihydroxyphenyl)-2(5H)-furanoneHuman immunodeficiency virus 1-ganomycin I709592-
3-(benzylsulfanyl)-4-hydroxy-6,6-diphenyl-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3-(benzylsulfanyl)-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3-(benzylsulfanyl)-4-hydroxy-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3-(benzylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1--718075-
3-(benzylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1--718075-
3-(benzylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1--718075-
3-(o-tolylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1--718075-
3-(o-tolylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1--718075-
3-(o-tolylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1--718075-
3-benzyl-4-hydroxy-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
3-Chloro-1-(4-chloro-phenyl)-propane-1,2-dione 1-oximeHuman immunodeficiency virus 1-highly inhibitory648140 2D-image
3-fluoro-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]-2-methylbenzamideHuman immunodeficiency virus 1--709749-
3-pentadecylphenolHuman immunodeficiency virus 1-isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba694787 2D-image
3-tert-Butylcarbamoyl-4-[2-hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-1-carboxylic acid benzyl esterHuman immunodeficiency virus 1-0.35-0.37 nM648128 2D-image
3-tridecylphenolHuman immunodeficiency virus 1-isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba694787 2D-image
3-[(10Z)-heptadec-10-en-1-yl]phenolHuman immunodeficiency virus 1-isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba694787 2D-image
3-[(2-tert-butyl-5-methylphenyl)sulfanyl]-4-hydroxy-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3-[(2-tert-butylphenyl)sulfanyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3-[(2-tert-butylphenyl)sulfanyl]-4-hydroxy-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3-[(8Z)-pentadec-8-en-1-yl]phenolHuman immunodeficiency virus 1-isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba694787 2D-image
3-[(benzylsulfanyl)(phenyl)methyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3-[1-(benzylsulfanyl)-2-cyclopropylethyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3-[1-(benzylsulfanyl)-3-methylbutyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3-[1-(cyclohexylsulfanyl)-2-cyclopropylethyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3-[1-(cyclopentylsulfanyl)-2-cyclopropylethyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3-[1-(cyclopentylsulfanyl)-3-methylbutyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3-[cyclopentyl(cyclopentylsulfanyl)methyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4,4'-[(3S,4S)-pyrrolidine-3,4-diylbis(benzylsulfamoyl)]dibenzamideHuman immunodeficiency virus 1--699555 2D-image
4,4'-[(3S,4S)-pyrrolidine-3,4-diylbis[[4-(trifluoromethyl)benzyl]sulfamoyl]]dibenzamideHuman immunodeficiency virus 1--699555 2D-image
4,7-dibenzyl-1,3-bis(2-chlorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(2-ethoxyethyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(2-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(3,3-dimethylbutyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(3-bromobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(3-chlorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(3-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(4-bromobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(4-chlorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(4-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(cyclobutylmethyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(cyclohexylmethyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(cyclopentylmethyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis(cyclopropylmethyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-bis[2-(ethenyloxy)ethyl]-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-dibutyl-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-diethyl-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-diheptyl-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1,3-dihexyl-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-1-decyl-5,6-dihydroxy-3-nonyl-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methoxybenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methoxyethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methylprop-2-en-1-yl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methylpropyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-hydroxybenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-iodobenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methoxybenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbut-2-en-1-yl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbutyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-nitrobenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-hydroxybenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-methoxybenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-methylbenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-methylpentyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(5-methylhexyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(naphthalen-1-ylmethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(naphthalen-2-ylmethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(pyridin-2-ylmethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(pyridin-3-ylmethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(pyridin-4-ylmethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[2-(2-methoxyethoxy)ethyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[2-(morpholin-4-yl)ethyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[3-(hydroxymethyl)benzyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[3-(trifluoromethyl)benzyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(hydroxymethyl)benzyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1-DMP323; enantiomer of DMP323709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(trifluoromethyl)benzyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-di(prop-2-en-1-yl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-di(prop-2-yn-1-yl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-dimethyl-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-dipentyl-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dibenzyl-5,6-dihydroxy-1,3-dipropyl-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4,7-dihydroxy-3-[4-(2-methoxyphenyl)butyl]-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
4-acetylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-4-acetylphenoxyacetylHuman immunodeficiency virus 1-IC50: 0.023 mM648152 2D-image
4-acetylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-4-acetylphenoxyacetylHuman immunodeficiency virus 1-IC50: 0.019 mM648152 2D-image
4-Benzyl-1-[2-hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 2.0 mM648128 2D-image
4-formylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-4-acetylphenoxyacetylHuman immunodeficiency virus 1-IC50: 0.08 mM648152 2D-image
4-formylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-4-acetylphenoxyacetylHuman immunodeficiency virus 1-IC50: 0.068 mM648152 2D-image
4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-3-(3-phenoxypropyl)-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-3-(4-phenylbutyl)-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-3-[(2-methylphenyl)sulfanyl]-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-3-[(2-methylphenyl)sulfanyl]-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-3-[3-(phenylsulfanyl)propyl]-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-3-[3-methyl-1-(phenylsulfanyl)butyl]-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-3-[4-(2-methoxyphenyl)butyl]-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-6-(3-methylbutyl)-6-phenyl-3-[(2-phenylethyl)sulfanyl]-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-6-(3-methylphenyl)-3-[[2-(propan-2-yl)phenyl]sulfanyl]-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-6-(4-hydroxyphenyl)-3-[(2-phenylethyl)sulfanyl]-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-6-pentyl-6-phenyl-3-[(2-phenylethyl)sulfanyl]-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-6-phenyl-3-(phenylsulfanyl)-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-6-phenyl-3-[(2-phenylethyl)sulfanyl]-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-6-phenyl-3-[(2-phenylethyl)sulfanyl]-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-6-phenyl-3-[(2-phenylethyl)sulfanyl]-6-propyl-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-6-phenyl-3-[phenyl(phenylsulfanyl)methyl]-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-6-phenyl-3-[[2-(propan-2-yl)phenyl]sulfanyl]-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-6-phenyl-6-(2-phenylethyl)-3-(phenylsulfanyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-6-phenyl-6-(2-phenylethyl)-3-[[2-(propan-2-yl)phenyl]sulfanyl]-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
4-hydroxy-7,8-dimethyl-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
4-oxo-4H-chromene-2-carboxylic acid (1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amideHuman immunodeficiency virus 1-IC50: 0.1 nM648128 2D-image
4-[[(6-[[(4-aminothiophen-2-yl)carbonyl]amino]-1,3-benzoxazol-2-yl)carbonyl]amino]thiophene-2-carboxylic acidHuman immunodeficiency virus 1-non-competitive707444-
5,5'-dithiobis(2-nitrobenzoic acid)Human immunodeficiency virus 1-enzyme activity is lost when a mixed disulfide is formed between 5,5'-dithiobis(2-nitrobenzoic acid) and Cys95, the same mixed disulfide at Cys67 reduces activity by 50%. Normal activity can be restored when the enzyme is treated with dithiothreitol648143 2D-image
5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenyl-3-(phenylthio)pyran-2-oneHuman immunodeficiency virus 1--718075-
5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenyl-3-(phenylthio)pyran-2-oneHuman immunodeficiency virus 1--718075-
5,6-dihydro-4-hydroxy-6-phenyl-3-(phenylthio)-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1--718075-
5-(3-chlorobenzyl)-1,2-dihydro-3H-pyrazol-3-oneHuman immunodeficiency virus 1--708083-
5-tridecylbenzene-1,3-diolHuman immunodeficiency virus 1-isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba694787 2D-image
5-[(8Z)-pentadec-8-en-1-yl]benzene-1,3-diolHuman immunodeficiency virus 1-isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba694787 2D-image
5-[4-hydroxy-6-oxo-2-phenyl-5-[(2-phenylethyl)sulfanyl]-3,6-dihydro-2H-pyran-2-yl]pentanoic acidHuman immunodeficiency virus 1--708083-
A-790742Human immunodeficiency virus 1-50% effective concentration ranges from 2 to 7 nM against wild-type HIV-1. The activity is lowered by approximately 7fold in the presence of 50% human serum. A-790742 maintains potent antiviral activity against lopinavir-resistant variants generated in vitro as well as against a panel of molecular clones containing proteases derived from HIV-1 patient isolates with multiple protease mutations. HIV-1 pNL4-3 clones with a single V82L or I84V mutation are phenotypically resistant to A-790742 and ritonavir695631 2D-image
A74704Human immunodeficiency virus 1--648125 2D-image
A79285Human immunodeficiency virus 1-a pseudo-C2 symmetric inhibitor, which contains a central difluoroketone motif648146 2D-image
Ac-His-Gly-Trp-Ile-PSI[N-CH(CH2(CH3)2)-CH(OH)-CH2-CH2-C(O)]-Glu-His-Gly-Asp-NH2Human immunodeficiency virus 1--648125 2D-image
Ac-HMSFNLHuman immunodeficiency virus 1-IC50: 0.19 mM648129 2D-image
Ac-HMTLNFHuman immunodeficiency virus 1--648129 2D-image
Ac-HTLNFHuman immunodeficiency virus 1--648129 2D-image
Ac-IGLTLNFHuman immunodeficiency virus 1--648129 2D-image
Ac-LTLNFHuman immunodeficiency virus 1--648129 2D-image
Ac-QIGMTLNFHuman immunodeficiency virus 1-IC50: 0.44 mM648129 2D-image
Ac-RASQNYHuman immunodeficiency virus 1-product inhibition with Ac-SQNYPVV as substrate648124 2D-image
Ac-RKILHuman immunodeficiency virus 1-product inhibition with Ac-RKILFLDG-NH2 as substrate648124 2D-image
Ac-SQNYHuman immunodeficiency virus 1-product inhibition with Ac-RASQNYPVV or Ac-SQNYFLDG-NH2 as substrate648124 2D-image
Ac-TI-Nle-(CH2-NH)-Nle-QR-amideHuman immunodeficiency virus 1--648132 2D-image
Ac-TLNFHuman immunodeficiency virus 1-IC50: 1.5 mM648129 2D-image
Ac-TLNF-NH2Human immunodeficiency virus 1-IC50 is above 2 mM648129 2D-image
Ac-TVSFNFHuman immunodeficiency virus 1-IC50: 0.08 mM648129 2D-image
Ace-T-I-Nle-r-Nle-Q-RHuman immunodeficiency virus 1-substrate analogue, competitive inhibition of the HIV-1 protease, mimicks the p2-NC cleavage site664895 2D-image
Ace-T-I-Nle-r-Nle-Q-RHuman immunodeficiency virus 1-substrate analogue peptide inhibitor666063 2D-image
acetyl pepstatinHuman immunodeficiency virus 1-0.1 mg/ml, 98.5% inhibition678626 2D-image
acetyl pepstatinHuman immunodeficiency virus 1-study on impact of active site region aspartyl residues 25 and 29 on the binding by differential scanning calorimetry. Binding is most sensitive to mutantion D25N, with DeltaTm ratio for mutant/wild-type of 16.3. Binding is nearly abolished by the mutation D29N701133 2D-image
acetyl-pepstatinHuman immunodeficiency virus 1--665102, 694787, 697300, 707180 2D-image
AG1776Human immunodeficiency virus 1--664013 2D-image
allyl N-[(1R,2S)-1-benzyl-2-hydroxy-3-[(4S)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1lambda6,2-benzothiazepin-2-yl]propyl]carbamateHuman immunodeficiency virus 1--717976-
alpha2-MacroglobulinHuman immunodeficiency virus 1-activity with Moloney murrine sarcoma virus-derived gag protein is inhibited at pH 5.5-7.4, activity with B chain of oxidized insulin is scarcely inhibited648130-
amprenavirHuman immunodeficiency virus 1--664605, 665976, 666106, 678346, 678616, 680381, 707512, 709580, 709749, 710390, 717975 2D-image
amprenavirHuman immunodeficiency virus 1-study on impact of active site region aspartyl residues 25 and 29 on the binding by differential scanning calorimetry. Binding is most sensitive to mutantion D25N, with DeltaTm ratio for mutant/wild-type of 35.8701133 2D-image
amprenavirHuman immunodeficiency virus 1Q7SSE3less effective on HIV-2 protease than on HIV-1 protease718370 2D-image
Arg-ArgHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Arg-Arg-LeuHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Arg-Arg-PheHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Arg-GluHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Arg-Glu-AspHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Arg-Glu-LeuHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Arg-Leu-Ala-PheHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Arg-Leu-Asn-PheHuman immunodeficiency virus 1-IC50: 0.87 mM648129 2D-image
Asp-AspHuman immunodeficiency virus 1--648141 2D-image
Asp-Asp-LeuHuman immunodeficiency virus 1--648141 2D-image
Asp-Asp-PheHuman immunodeficiency virus 1--648141 2D-image
Asp-Glu-LeuHuman immunodeficiency virus 1--648141 2D-image
Asp-Leu-Ala-PheHuman immunodeficiency virus 1--648141 2D-image
atazanavirHuman immunodeficiency virus 1--665976, 678346, 678616, 680381, 707512, 708410, 709481, 709749, 710390, 717096, 717975 2D-image
atazanavirHuman immunodeficiency virus 1-study on impact of active site region aspartyl residues 25 and 29 on the binding by differential scanning calorimetry701133 2D-image
atazanavirHuman immunodeficiency virus 1-study on the use of suboptimal concentrations of inhibitors atazanavir and lopinavir. Even with high levels of inhibition of viral infectivity, IC90, most of the Gag and Gag-Pol polyproteins are processed, although slight but significant increases in processing intermediates of Gag Are detected. Drug treatments cause a significant increase in the proportion of viruses displaying either immature or aberrant mature morphologies. The aberrant mature particles are characterized by an electron-dense region at the viral periphery and an electron-lucent core structure in the viral center. Drug treatments cause only a slight decrease in overall thermodynamic stability of the viral RNA dimer701392 2D-image
ATBIHuman immunodeficiency virus 1-aspartic protease inhibitor: Ala-Gly-Lys-Lys-Asp-Asp-Asp-Asp-Pro-Pro-Glu, from Bacillus sp.710216-
BEA369Human immunodeficiency virus 1-molecular dynamics simulation study on the role of protonation in the protease complex with inhibitor BEA369. Protonation of aspartic acids Asp25/Asp25' has a strong influence on the dynamics behavior of the complex, the binding free energy of BEA369, and inhibitor-residue interactions. Relative binding free energies show that protonation of Asp25 results in the strongest binding of BEA369 to HIV-1 protease. Inhibitor-residue interactions indicate that protonation of Asp25 has the most favorable effect on binding of BEA369. Protonation of Asp25 strongly influences the water-mediated link of a conserved water molecule, Wat301699630 2D-image
benzyl [(5S,8S,9R,10R,11S,14S)-8,11-dibenzyl-9,10-dihydroxy-15-methyl-3,6,13-trioxo-1-phenyl-5-(propan-2-yl)-2-oxa-4,7,12-triazahexadecan-14-yl]carbamateHuman immunodeficiency virus 1--708383-
bis-[(L-valine-N-methylamide)-2-phenyl-3-yl-propionamide] sulfideHuman immunodeficiency virus 1--707740-
bis-[(L-valine-N-methylamide)-2-phenyl-3-yl-propionamide] sulfoxideHuman immunodeficiency virus 1--707740-
bis-[(L-valine-N-methylamide)-2-phenyl-3-yl-propionamide] sulfoximineHuman immunodeficiency virus 1--707740-
bis-[[N-(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-2S-phenyl-3-yl-propionamide] sulfoximineHuman immunodeficiency virus 1--707740-
bis-[[N-(2R)-phenylglycinol]-2-phenyl-3-yl-propionamide] sulfideHuman immunodeficiency virus 1--707740-
bis-[[N-(2R)-phenylglycinol]-2-phenyl-3-yl-propionamide] sulfoxideHuman immunodeficiency virus 1--707740-
bis-[[N-(2R)-phenylglycinol]-2-phenyl-3-yl-propionamide]sulfoximineHuman immunodeficiency virus 1--707740-
bis-[[N-(2S)-phenylglycinol]-2-phenyl-3-yl-propionamide] sulfideHuman immunodeficiency virus 1--707740-
bis-[[N-(2S)-phenylglycinol]-2-phenyl-3-yl-propionamide] sulfoxideHuman immunodeficiency virus 1--707740-
bis-[[N-(2S)-phenylglycinol]-2-phenyl-3-yl-propionamide] sulfoximineHuman immunodeficiency virus 1--707740-
compound JHuman immunodeficiency virus 1--678616 2D-image
darunavirHuman immunodeficiency virus 1--680381, 680900, 699546, 707512, 709443, 709481, 709749, 710390, 717096, 717348, 717971, 717975, 717976, 718370, 718373 2D-image
darunavirHuman immunodeficiency virus 1-mutations in the gag region NC-p1/TFP-p6/p6pol may influence the selection of darunavir resistance mutations. The I437T/V gag mutation that confers resistance to protease inhibitors reduces the selection of such mutations. Virus with L76V in protease or I437T/V in gag may be already resistant to darunavir698516 2D-image
darunavirHuman immunodeficiency virus 1-study on impact of active site region aspartyl residues 25 and 29 on the binding by differential scanning calorimetry701133 2D-image
darunavirHuman immunodeficiency virus 1-TMC-114709582 2D-image
DMP128Human immunodeficiency virus 1--709258-
DMP323Human immunodeficiency virus 1--648133, 648164, 709258, 718373 2D-image
dryopteric acid AHuman immunodeficiency virus 1-inhibitor isolated from Dryopteris crassirhizoma697300 2D-image
dryopteric acid BHuman immunodeficiency virus 1-inhibitor isolated from Dryopteris crassirhizoma697300 2D-image
E-R-Q-A-N-r-F-L-G-K-IHuman immunodeficiency virus 1-substrate analogue, competitive inhibition of the HIV-1 protease, mimicks the NC/p1 cleavage site664895 2D-image
ethyl N-[(1R,2S)-1-benzyl-2-hydroxy-3-[(4S)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1lambda6,2-benzothiazepin-2-yl]propyl]carbamateHuman immunodeficiency virus 1--717976-
FLREDLAFHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
fosamprenavirHuman immunodeficiency virus 1--717096-
fullerene C60Human immunodeficiency virus 1-„Bucky Ball'648133 2D-image
GADIFYLDGAHuman immunodeficiency virus 1--682770 2D-image
GAEVFYVDGAHuman immunodeficiency virus 1--682770 2D-image
ganomycin BHuman immunodeficiency virus 1-competitive inhibition709592 2D-image
GAQTFYVDGAHuman immunodeficiency virus 1--682770 2D-image
GEDLAFHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Glu-Arg-LeuHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Glu-Arg-Leu-AlaHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Glu-Arg-PheHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Glu-Asn-LeuHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Glu-Asp-LeuHuman immunodeficiency virus 1--648141 2D-image
Glu-Asp-Leu-AlaHuman immunodeficiency virus 1--648141 2D-image
Glu-Asp-PheHuman immunodeficiency virus 1--648141 2D-image
Glu-Glu-LeuHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
Glu-Lys-PheHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141 2D-image
GRL-06579AHuman immunodeficiency virus 1--709443 2D-image
GRL-98065Human immunodeficiency virus 1-I50V, V82A and I84V mutant proteins show high levels of resistence708386-
IGRNLLTQIGCTLNFHuman immunodeficiency virus 1-IC50: 0.41 mM648129 2D-image
indinavirHuman immunodeficiency virus 1-IC50: 1.3 nM648152 2D-image
indinavirHuman immunodeficiency virus 1--664013, 665976, 666063, 666106, 680381, 681460, 699896, 707512, 707528, 709258, 709332, 709481, 709749, 710390, 717096, 717975, 718075 2D-image
indinavirHuman immunodeficiency virus 1-drug used in AIDS therapy, mechanism of drug resistance, overview666078 2D-image
indinavirHuman immunodeficiency virus 1-structural analyses of the subtype C protease bound to nelfinavir and indinavir showed that these inhibitors form similar interactions with the residues in the active site of subtype B and C proteases678346 2D-image
indinavirHuman immunodeficiency virus 1-study on impact of active site region aspartyl residues 25 and 29 on the binding by differential scanning calorimetry701133 2D-image
indinavirHuman immunodeficiency virus 1-98.8% inhibition at 10 nM717348 2D-image
JG-365Human immunodeficiency virus 1--708877 2D-image
JG365Human immunodeficiency virus 1--648125 2D-image
JG365Human immunodeficiency virus 1-9 nM648128 2D-image
KNI-272Human immunodeficiency virus 1--664299, 708877 2D-image
KNI-272Human immunodeficiency virus 1-transition-state analog710423 2D-image
KNI-279Human immunodeficiency virus 1--664299 2D-image
KNI-727Human immunodeficiency virus 1-potent, small, water-soluble dipeptide-type HIV-1 protease inhibitor664299 2D-image
KVS-1Human immunodeficiency virus 1--708877-
Kyn-(D-alpha-(2-thienyl)glycine)-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetylHuman immunodeficiency virus 1-IC50: 3 nM648152 2D-image
Kyn-Thr-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetylHuman immunodeficiency virus 1-IC50: 4 nM648152 2D-image
Kyn-Val-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetylHuman immunodeficiency virus 1-IC50: 3 nM648152 2D-image
Kyn-Val-Phe-PSI(S,R,S)[OH]-Phe-Val-KynHuman immunodeficiency virus 1-IC50: 4 nM648152 2D-image
Kyn-Val-Phe-PSI(S,S,S)[OH]-Phe-2,6-dimethylphenoxyacetylHuman immunodeficiency virus 1-IC50: 3 nM648152 2D-image
L-700,417Human immunodeficiency virus 1-IC50: 0.67 mM648125 2D-image
L-704,486Human immunodeficiency virus 1-IC50: 7.8 nM648128 2D-image
Leu-Leu-Glu-Tyr-Val-Met-OHHuman immunodeficiency virus 1-0.1 mg/ml, 47.2% inhibition678626 2D-image
Leu-Leu-Glu-Tyr-Val-Phe-OHHuman immunodeficiency virus 1-0.1 mg/ml, 52.3% inhibition678626 2D-image
Leu-Leu-Glu-Tyr-Val-Trp-OHHuman immunodeficiency virus 1-0.1 mg/ml, 64.9% inhibition678626 2D-image
Leu-Leu-Glu-Tyr-Val-Tyr-OHHuman immunodeficiency virus 1-0.1 mg/ml, 58.6% inhibition678626 2D-image
lopinavirHuman immunodeficiency virus 1--665976, 666106, 678346, 678616, 680381, 681460, 707512, 709481, 709749, 710390, 717096, 717971, 717975 2D-image
lopinavirHuman immunodeficiency virus 1-computer simulation of comlex with HIV-1 protease699197 2D-image
lopinavirHuman immunodeficiency virus 1-study on impact of active site region aspartyl residues 25 and 29 on the binding by differential scanning calorimetry701133 2D-image
lopinavirHuman immunodeficiency virus 1-study on the use of suboptimal concentrations of inhibitors atazanavir and lopinavir. Even with high levels of inhibition of viral infectivity, IC90, most of the Gag and Gag-Pol polyproteins are processed, although slight but significant increases in processing intermediates of Gag Are detected. Drug treatments cause a significant increase in the proportion of viruses displaying either immature or aberrant mature morphologies. The aberrant mature particles are characterized by an electron-dense region at the viral periphery and an electron-lucent core structure in the viral center. Drug treatments cause only a slight decrease in overall thermodynamic stability of the viral RNA dimer701392 2D-image
LTLNFHuman immunodeficiency virus 1--648129 2D-image
lysyl-tRNA synthetaseHuman immunodeficiency virus 1--662382-
manassantin AHuman immunodeficiency virus 1--707180-
methyl (7S,10R,16S)-10-benzyl-13-(4-bromobenzyl)-10-hydroxy-7-isopropyl-17,17-dimethyl-6,9,15-trioxo-2-oxa-5,8,13,14-tetraazaoctadecan-16-ylcarbamateHuman immunodeficiency virus 1--709481-
methyl (7S,10S,16S)-10-benzyl-13-(4-bromobenzyl)-10-hydroxy-7-isopropyl-17,17-dimethyl-6,9,15-trioxo-2-oxa-5,8,13,14-tetraazaoctadecan-16-ylcarbamateHuman immunodeficiency virus 1--709481-
methyl (S)-1-(2-((R)-3-benzyl-3-hydroxy-4-((S)-3-methyl-1-(methylamino)-1-oxobutan-2-ylamino)-4-oxobutyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1--709481-
methyl (S)-1-(2-((R)-3-benzyl-4-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-hydroxy-4-oxobutyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1--709481-
methyl (S)-1-(2-((S)-3-benzyl-3-hydroxy-4-((S)-3-methyl-1-(methylamino)-1-oxobutan-2-ylamino)-4-oxobutyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1--709481-
methyl (S)-1-(2-((S)-3-benzyl-4-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-hydroxy-4-oxobutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1--709481-
methyl (S)-1-(2-((S)-3-benzyl-4-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-hydroxy-4-oxobutyl)-2-(4-(pyridin-3-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1--709481-
methyl (S)-1-(2-((S)-3-benzyl-4-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-hydroxy-4-oxobutyl)-2-(4-(pyridin-4-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1--709481-
methyl (S)-1-(2-((S)-3-benzyl-4-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-hydroxy-4-oxobutyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1--709481-
methyl 4-[([6-[([4-[(tert-butoxycarbonyl)amino]thiophen-2-yl]carbonyl)amino]-1,3-benzoxazol-2-yl]carbonyl)amino]thiophene-2-carboxylateHuman immunodeficiency virus 1-; non-competitive707444-
methyl [(2S)-1-[2-[(2S)-2-benzyl-2-hydroxy-3-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-3-oxopropyl]-2-[4-(pyridin-3-yl)benzyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamateHuman immunodeficiency virus 1--709481-
methyl [(2S)-1-[2-[(4R)-4-benzyl-4-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-2-[4-(pyridin-4-yl)benzyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamateHuman immunodeficiency virus 1--709481-
methyl [3-[(5S)-5-([(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]carbamateHuman immunodeficiency virus 1--717971-
morpholine-4-carboxylic acid (1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amideHuman immunodeficiency virus 1-IC50: 2.4 nM648128 2D-image
MTLNFHuman immunodeficiency virus 1--648129 2D-image
MTV-101Human immunodeficiency virus 1--708877-
MVT-101Human immunodeficiency virus 1--648120, 648125 2D-image
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(4-amino-N-benzylbenzenesulfonamide)Human immunodeficiency virus 1--699555 2D-image
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(4-iodobenzyl)benzenesulfonamide]Human immunodeficiency virus 1--699555 2D-image
N-(1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-isonicotinamideHuman immunodeficiency virus 1-IC50: 1.3 nM648128 2D-image
N-(1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-nicotinamideHuman immunodeficiency virus 1-IC50: 0.8 nM648128 2D-image
N-methyl bis-[N-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[(1S,2R)-1,2]-oxazol-3-yl) 2R-benzyl-3-yl propianamide] sulfoximineHuman immunodeficiency virus 1--707740-
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]propyl]-2-thiophen-3-ylacetamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]propyl]pyridazine-4-carboxamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-2,4,5-trifluoro-3-hydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-2-methylbenzamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-3,4,5-trihydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-3,4-dihydroxybenzamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-3-fluoro-2-methylbenzamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]-3-hydroxybenzamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]-4-oxohexanamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]cyclopropane-1,1-dicarboxamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]-3-hydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]-4-oxohexanamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]cyclopropane-1,1-dicarboxamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]-3-hydroxybenzamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]-4-oxohexanamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]cyclopropane-1,1-dicarboxamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-1-benzyl-3-[(butylsulfonyl)(3-chlorobenzyl)amino]-2-hydroxypropyl]-2,3-dichlorobenzamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-1-benzyl-3-[(butylsulfonyl)(3-chlorobenzyl)amino]-2-hydroxypropyl]-2-bromo-3-methylbenzamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]-3-hydroxybenzamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]-4-oxohexanamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]cyclopropane-1,1-dicarboxamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]-3-hydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]-4-oxohexanamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]cyclopropane-1,1-dicarboxamideHuman immunodeficiency virus 1--680381 2D-image
N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]-3-hydroxybenzamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]-4-oxohexanamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]cyclopropane-1,1-dicarboxamideHuman immunodeficiency virus 1--680381 2D-image
N-[(2R,6S)-6-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-7-hydroxyheptan-2-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1--717327-
N-[(2S)-2-[(N-acetylthreonylisoleucyl)amino]hexyl]norleucyl-N-(3-carbamimidamido-1-carbamoylpropyl)-6-oxolysinamideHuman immunodeficiency virus 1-i.e. RPB, nonhydrolyzable substrate analogue. Study on impact of active site region aspartyl residues 25 and 29 on the binding by differential scanning calorimetry. Binding is nearly abolished by the mutation D29N, but hyrdly affected by mutation D25N701133 2D-image
N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-phenylbutan-2-yl]-4-oxohexanamideHuman immunodeficiency virus 1--709749-
N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamideHuman immunodeficiency virus 1--709749-
N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamideHuman immunodeficiency virus 1--709749-
N-[(2S,3R)-4-[(cyclopropylmethyl)(furan-2-ylsulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamideHuman immunodeficiency virus 1--709749-
N-[(2S,3R)-4-[(cyclopropylmethyl)[(3-methoxyphenyl)sulfonyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamideHuman immunodeficiency virus 1--709749-
N-[(2S,6S)-6-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-7-hydroxyheptan-2-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1--717327-
N-[(3S,7S)-7-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-1,8-dihydroxyoctan-3-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1--717327-
N-[(3S,7S)-7-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-8-hydroxy-2-methyloctan-3-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1--717327-
N-[(3S,7S)-7-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-8-hydroxyoctan-3-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1--717327-
N-[(4S,8S)-8-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-9-hydroxynonan-4-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1--717327-
N-[(5S)-5-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-6-hydroxyhexyl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1--717327-
N-[(5S)-5-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-6-hydroxyhexyl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1--717327-
N1-[1-Benzyl-3-(2-tert-butylcarbamoyl-pyrrolidin-1-yl)-2-methoxy-3-oxo-propyl]-2-[2-(naphthalen-1-yloxy)-acetylamino]-succinamideHuman immunodeficiency virus 1--648128 2D-image
N2-acetyl-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]propyl]-L-alaninamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
N2-acetyl-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]-L-valinamideHuman immunodeficiency virus 1--680381 2D-image
N2-acetyl-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]-L-valinamideHuman immunodeficiency virus 1--680381 2D-image
N2-acetyl-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]-L-valinamideHuman immunodeficiency virus 1--680381 2D-image
N2-acetyl-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]-L-valinamideHuman immunodeficiency virus 1--680381 2D-image
N2-acetyl-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]-L-valinamideHuman immunodeficiency virus 1-broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants680381 2D-image
N2-acetyl-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]-L-valinamideHuman immunodeficiency virus 1--680381 2D-image
N2-acetyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-L-alaninamideHuman immunodeficiency virus 1--709749-
N2-acetyl-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-L-valinamideHuman immunodeficiency virus 1--709749-
N2-[(2S)-2-[(3R)-5-[(1S)-1-(L-alanylamino)ethyl]-3-benzyl-2,3,6,7-tetrahydro-1H-azepin-1-yl]propanoyl]-N-[(1S,2S,4R)-1-benzyl-2-hydroxy-4-[5-(2-methylpropanoyl)-1H-imidazol-2-yl]-5-phenylpentyl]-L-valinamideHuman immunodeficiency virus 1--681109 2D-image
N2-[(2S,4S,5S)-5-(acetylamino)-6-cyclohexyl-4-hydroxy-2-(1-methylethyl)hexanoyl]-L-glutaminyl-L-argininamideHuman immunodeficiency virus 1--681109 2D-image
nelfinavirHuman immunodeficiency virus 1-IC50: 1.9 nM648152 2D-image
nelfinavirHuman immunodeficiency virus 1--664013, 665976, 678616, 680381, 699896, 707378, 707512, 707528, 708410, 709258, 709467, 709749, 710346, 710390, 717096 2D-image
nelfinavirHuman immunodeficiency virus 1-structural analyses of the subtype C protease bound to nelfinavir and indinavir showed that these inhibitors form similar interactions with the residues in the active site of subtype B and C proteases678346 2D-image
nelfinavirHuman immunodeficiency virus 1-in the HIV-1 protease sequence of viral variants resistant to the inhibitor nelfinavir, the mutations D30N and L90M appear frequently681460 2D-image
nelfinavirHuman immunodeficiency virus 1-computer simulation of comlex with HIV-1 protease699197 2D-image
nelfinavirHuman immunodeficiency virus 1-study on impact of active site region aspartyl residues 25 and 29 on the binding by differential scanning calorimetry701133 2D-image
P27 peptideHuman immunodeficiency virus 1-i.e. PQITLRKKRRQRRRPPQVSFNFCTLNF. Incubation of mutant L10I/K45R/I54V/L63P/A71V/V82T/L90M/I93L with peptide leads to dose- and time-dependent formation of protease monomers, while incubation with a active-site inhibitor does not change the elution profile of the protease. The monomeric protease induced by P27 has fluorescent characteristics consistent with unfolded protein696116-
PepstatinHuman immunodeficiency virus 1--707721 2D-image
pepstatin AHuman immunodeficiency virus 1--648140, 665102, 709592 2D-image
Phe-Asp-Asp-PheHuman immunodeficiency virus 1-with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate648141-
Phe-Leu-Asp-GlyHuman immunodeficiency virus 1-product inhibition with Ac-RKILFLDG-NH2 as substrate648124-
Phe-Leu-Asp-Gly-NH2Human immunodeficiency virus 1-product inhibition with Ac-SQNYFLDG-NH2 as substrate648124 2D-image
phenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-phenoxyacetylHuman immunodeficiency virus 1-IC50: 0.017 mM648152-
phenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-phenoxyacetylHuman immunodeficiency virus 1-IC50: 0.005 mM648152-
phenyl N-[(1R,2S)-1-benzyl-2-hydroxy-3-[(4S)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1lambda6,2-benzothiazepin-2-yl]propyl]carbamateHuman immunodeficiency virus 1--717976-
pyridin-3-ylmethyl [(5S,8S,9R,10R,11S,14S)-8,11-dibenzyl-9,10-dihydroxy-15-methyl-3,6,13-trioxo-5-(propan-2-yl)-1-(pyridin-3-yl)-2-oxa-4,7,12-triazahexadecan-14-yl]carbamateHuman immunodeficiency virus 1--708383-
pyridine-2-carboxylic acid (1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amideHuman immunodeficiency virus 1-IC50: 4.6 nM648128 2D-image
pyrrolidinemehylene diamine derivativesHuman immunodeficiency virus 1-binding mode of pyrrolidine-based aspartyl protease inhibitors: design, synthesis and crystal structure in complex with HIV protease, overview664605-
QF34Human immunodeficiency virus 1--709258-
R-P-G-N-F-r-L-Q-S-R-PHuman immunodeficiency virus 1-substrate analogue, competitive inhibition of the HIV-1 protease, mimicks the pI-p6 cleavage site664895 2D-image
R-V-L-r-F-E-A-NleHuman immunodeficiency virus 1-substrate analogue, competitive inhibition of the HIV-1 protease, mimicks the CA/p2 cleavage site664895 2D-image
R-V-L-r-F-E-A-NleHuman immunodeficiency virus 1-substrate analogue peptide inhibitor666063 2D-image
rac-(3S,4S)-N-benzyl-2-(2,6-dimethyl-phenoxy)-N-4-[[(isobutyl-(toluene-4-sulfonyl)-amino)-methyl]-pyrrolidin-3-ylmethyl]-acetamideHuman immunodeficiency virus 1-IC50 is 0.0121 mM, binding structure analysis, modelling664605 2D-image
rac-(3S,4S)-N-[4-([4-amino-benzenesulfonyl-isobutyl-amino]-methyl)-pyrrolidin-3-ylmethyl]-N-benzyl-2-(2,6-dimethyl-phenoxy)-acetamideHuman immunodeficiency virus 1-IC50 is 0.0033 mM, binding structure analysis, modelling664605 2D-image
rac-(3S,4S)-N-[4-([benzenesulfonyl-isobutyl-amino]-methyl)-pyrrolidin-3-ylmethyl]-N-benzyl-2-(2,6-dimethyl-phenoxy)-acetamideHuman immunodeficiency virus 1-IC50 is 0.0022 mM, binding structure analysis, modelling664605 2D-image
renin inhibitorsHuman immunodeficiency virus 1--648132-
ritonavirHuman immunodeficiency virus 1-IC50: 3 nM648152 2D-image
ritonavirHuman immunodeficiency virus 1--664013, 665976, 666106, 678346, 678616, 680381, 681460, 699896, 707512, 709332, 709481, 709580, 709749, 710390, 717975 2D-image
ritonavirHuman immunodeficiency virus 1-HIV-1 pNL4-3 clones with a single V82L or I84V mutation are phenotypically resistant to A-790742 and ritonavir695631 2D-image
ritonavirHuman immunodeficiency virus 1-study on impact of active site region aspartyl residues 25 and 29 on the binding by differential scanning calorimetry701133 2D-image
ritronavirHuman immunodeficiency virus 1--707528-
RTLNLGLHuman immunodeficiency virus 1-IC50 is above 0.8 mM648129 2D-image
saquinavirHuman immunodeficiency virus 1--648142, 648162, 665976, 678346, 678616, 680381, 681460, 699546, 699896, 707512, 708410, 709258, 709332, 709467, 709481, 709749, 710390, 717096, 717975, 718370 2D-image
saquinavirHuman immunodeficiency virus 1-study on impact of active site region aspartyl residues 25 and 29 on the binding by differential scanning calorimetry701133 2D-image
saururin BHuman immunodeficiency virus 1--707180-
SB203386Human immunodeficiency virus 1--648139 2D-image
SB204,144Human immunodeficiency virus 1--648125 2D-image
schisanlactone AHuman immunodeficiency virus 1-dimerization inhibitor709592-
Ser-Leu-Asn-PheHuman immunodeficiency virus 1-IC50: 0.47 mM648129 2D-image
SFNLHuman immunodeficiency virus 1-IC50: 0.28 mM648129 2D-image
SFNLEHuman immunodeficiency virus 1-IC50: 0.31 mM648129 2D-image
SKF 107457Human immunodeficiency virus 1--648125 2D-image
SKF 108361Human immunodeficiency virus 1--648125 2D-image
t-butyl 3-isopropyl-3-(2S,3S)-2-hydroxy-3-(-quinaldoyl-L-asparaginyl)amino-4-phenylbutylcarbazateHuman immunodeficiency virus 1-i.e. DG-35-VIII, inhibits processing of the Pr55gag and Pr160gag-pol precursor proteins648149 2D-image
tert-butoxycarbonyl-Phe-psi[CH2CH2NH]-Phe-Glu-Phe-NH2Human immunodeficiency virus 1-i.e. tert-butoxycarbonyl-Phe-psi[CH2CH2NH]-Phe-Glu-Phe-NH2, an ethyleneamine inhibitor, interactions with the enzyme, overview665991 2D-image
tert-butoxycarbonyl-Phe-psi[S-CH(OH)CH2NH]-Phe-Gln-Phe-NH2Human immunodeficiency virus 1-i.e. tert-butoxycarbonyl-Phe-psi[S-CH(OH)CH2NH]-Phe-Gln-Phe-NH2, a pseudotetrapeptide inhibitor with an acyclic S-hydroxyethylamine isostere, interactions with the enzyme and binding structure, overview665991 2D-image
tert-butoxycarbonyl-Phe-psi[S-CH(OH)CH2NH]-Phe-Glu-Phe-NH2Human immunodeficiency virus 1-i.e. tert-butoxycarbonyl-Phe-psi[S-CH(OH)CH2NH]-Phe-Glu-Phe-NH2, a pseudotetrapeptide inhibitor with an acyclic S-hydroxyethylamine isostere, interactions with the enzyme and binding structure, overview665991 2D-image
tert-butoxycarbonyl-Phe-psi[S-CH(OH)CH2]-Phe-Gln-Phe-NH2Human immunodeficiency virus 1-i.e. tert-butoxycarbonyl-Phe-psi[S-CH(OH)CH2]-Phe-Gln-Phe-NH2, a hydroxyethylene inhibitor, interactions with the enzyme, overview665991 2D-image
tert-butyl N-[(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1lambda6,2-benzothiazepin-2-yl]-2-hydroxypropyl]carbamateHuman immunodeficiency virus 1--717976-
tert-butyl N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(4S)-4-methyl-1,1-dioxo-7-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-1lambda6,-2-benzothiazepin-2-yl]propyl]carbamateHuman immunodeficiency virus 1--717976-
tert-butyl N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(4S)-4-methyl-1,1-dioxo-8-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-1lambda6,-2-benzothiazepin-2-yl]propyl]carbamateHuman immunodeficiency virus 1--717976-
tert-butyl N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(4S)-7-methoxy-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1lambda6,2-benzothiazepin-2-yl]propyl]carbamateHuman immunodeficiency virus 1--717976-
Thr-Leu-Asn-LeuHuman immunodeficiency virus 1-IC50: 0.38 mM648129 2D-image
Thr-Leu-Asn-Phe-NH2Human immunodeficiency virus 1-IC50 is above 2 mM648129 2D-image
Thr-Leu-Asn-TyrHuman immunodeficiency virus 1-IC50 is about 1 mM648129 2D-image
Thr-Phe-Asn-PheHuman immunodeficiency virus 1-IC50: 0.45 mM648129 2D-image
tipranavirHuman immunodeficiency virus 1-IC50 is 30 nM, interacts with residues Asp25 and Asp25', and Ile50 and Ile50'664605 2D-image
tipranavirHuman immunodeficiency virus 1--665976, 678346, 680381, 707512, 709749, 710390, 717096, 717971 2D-image
tipranavirHuman immunodeficiency virus 1-study on impact of active site region aspartyl residues 25 and 29 on the binding by differential scanning calorimetry701133 2D-image
TL-3Human immunodeficiency virus 1--707528 2D-image
TLNLGFHuman immunodeficiency virus 1-IC50 is above 0.8 mM648129 2D-image
U-71017Human immunodeficiency virus 1-i.e. Poa-His-Cha-PSI[CH(OH)CH2]Val-Ile-Amp648136 2D-image
U-71038Human immunodeficiency virus 1-i.e. Boc-Pro-Phe-Nalpha-MeHis-Leu-PSI[CH(OH)CH2]Val-Ile-Amp648136 2D-image
U-75875Human immunodeficiency virus 1--648125 2D-image
U-75875Human immunodeficiency virus 1-i.e. Noa-His-Cha-PSI[CH(OH)CH2]Val-Ile-Amp648136 2D-image
U-79213Human immunodeficiency virus 1-i.e. Poa-His-Cha-PSI[CH(OH)CH2]Val-Ile-Amp648136 2D-image
U-81749EHuman immunodeficiency virus 1-i.e. Tba-Cha-PSI[CH(OH)CH2]Val-Ile-Amp648136 2D-image
U-85548EHuman immunodeficiency virus 1--648125 2D-image
U-89360EHuman immunodeficiency virus 1--648147, 648171 2D-image
UCSF8Human immunodeficiency virus 1--648125 2D-image
UIC-94017Human immunodeficiency virus 1-TMC-114, a broad-spectrum, potent non-peptide inhibitor of HIV-1 protease, the inhibitor shows low cytotoxicity, enzyme binding structure analysis666016 2D-image
ursolic acidHuman immunodeficiency virus 1--697300 2D-image
ursolic acidHuman immunodeficiency virus 1-dimerization inhibitor709592 2D-image
V-S-F-N-F-r-P-Q-I-T-K-KHuman immunodeficiency virus 1-substrate analogue, competitive inhibition of the HIV-1 protease, mimicks the p6pol-PR cleavage site664895 2D-image
XK263Human immunodeficiency virus 1--709258-
[1-(1-Benzyl-3-benzylcarbamoyl-3,3-difluoro-2-oxo-propylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl esterHuman immunodeficiency virus 1--648128 2D-image
[1-(1-{1-benzyl-3-[2-(1-tert-butylcarbamoyl-2-methyl-butylcarbamoyl)-pyrrolidin-1-yl]-2-methoxy-propylcarbamoyl}-2-carbamoyl-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl esterHuman immunodeficiency virus 1-IC50: 750 nM648128 2D-image
[1-Benzyl-2-hydroxy-4-(3-hydroxy-indan-1-ylcarbamoyl)-7-phenyl-hept-6-enyl]-carbamic acid tert-butyl esterHuman immunodeficiency virus 1-IC50: 0.55 nM648128 2D-image
[1-Benzyl-3-(3-benzyl-1-isothiochroman-4-yl-2-oxo-pyrrolidin-3-yl)-2-hydroxy-propyl]-carbamic acid tert-butyl esterHuman immunodeficiency virus 1-IC50: 111 nM648128 2D-image
[1-Benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propyl]-carbamic acid tert-butyl esterHuman immunodeficiency virus 1-IC50: 17 nM648128 2D-image
[1-Benzyl-4-(2,2-dioxo-2lambda6-isothiochroman-4-ylcarbamoyl)-2-hydroxy-7-phenyl-hept-6-enyl]-carbamic acid tert-butyl esterHuman immunodeficiency virus 1-IC50: 2.3 nM648128 2D-image
{1-benzyl-3-[3-benzyl-1-(2,2-dioxo-2l6-isothiochroman-4-yl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propyl}-carbamic acid tert-butyl esterHuman immunodeficiency virus 1-IC50: 14 nM648128 2D-image
{1-benzyl-3-[3-benzyl-1-(2-hydroxy-indan-1-yl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propyl}-carbamic acid tert-butyl esterHuman immunodeficiency virus 1-37 nM648128 2D-image
{1-[1-benzyl-3-(2-tert-butylcarbamoyl-piperidin-1-yl)-2-methoxy-propylcarbamoyl]-2-carbamoyl-ethyl}-carbamic acid benzyl esterHuman immunodeficiency virus 1-IC50: 18 nM648128 2D-image
{1-[1-benzyl-3-(2-tert-butylcarbamoyl-pyrrolidin-1-yl)-2-methoxy-propylcarbamoyl]-2-carbamoyl-ethyl}-carbamic acid benzyl esterHuman immunodeficiency virus 1-IC50: 210 nM648128 2D-image
methyl [3-[(5S)-5-[[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]carbamoyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]carbamateHuman immunodeficiency virus 1--717971-
additional informationHuman immunodeficiency virus 1-design of tight-binding human immunodeficiency virus type 1 protease inhibitors648128-
additional informationHuman immunodeficiency virus 1-oxim derivatives containing halogenomethylketone and phenyl moieties are specific HIV-1 protease inhibitors648140-
additional informationHuman immunodeficiency virus 1-RVL-(reduced peptide bond)-FEA-Nle-NH2 and Ac-TI-Nle-(reduced peptide bond)-Nle-QR-NH2648153-
additional informationHuman immunodeficiency virus 1-design of hydrolytically-stable cyclic peptidomimetic inhibitors of HIV-1 protease648175-
additional informationHuman immunodeficiency virus 1-substrate-based cyclic peptidomimetics of Phe-Ile-Val that inhibit HIV-1 protease using a novel enzyme-binding mode648176-
additional informationHuman immunodeficiency virus 1-active site inhibitor binding structure analysis, overview664013-
additional informationHuman immunodeficiency virus 1-synthesis of diverse prodrugs of the water-soluble dipeptide-type HIV-1 protease inhibitors KNI-727, KNI-272, and KNI-279 by O to N acyl migration, and analysis of the water-solubility and stability of the prodrugs, overview664299-
additional informationHuman immunodeficiency virus 1-molecular basis for substrate recognition and drug resistance, structure analysis of substrate analogue inhibitors bound to wild-type enzyme, mutant V82A enzyme, and mutant I84V enzyme, overview664895-
additional informationHuman immunodeficiency virus 1-design of enzyme inhibitors active on multidrug-resistant virus, overview665976-
additional informationHuman immunodeficiency virus 1-inhibition analysis with eight clinically used protease inhibitors reveales that the natural polymorphisms found in subtype C protease, in combination with drug resistance mutations, can influence enzymatic catalytic efficiency and inhibitor resistance678346-
additional informationHuman immunodeficiency virus 1-the conformational flexibility of HIV-1 protease inhibitors directly contributes to the enzyme inhibition681109-
additional informationHuman immunodeficiency virus 1-two possible mechanisms of the irreversible inhibition of HIV-1 protease by epoxide inhibitors are investigated on an enzymatic model using ab initio (MP2) and density functional theory methods (B3LYP, MPW1K and M05-2X). The calculations predict the inhibition as a general acid-catalyzed nucleophilic substitution reaction proceeding by a concerted SN2 mechanism with a reaction barrier of ca. 15–21 kcal/mol. The irreversible nature of the inhibition is characterized by a large negative reaction energy of ca. -17-(-24) kcal/mol. A mechanism with a direct proton transfer from an aspartic acid residue of the active site onto the epoxide ring has been shown to be preferred compared to one with the proton transfer from the acid catalyst facilitated by a bridging catalytic water molecule682227-
additional informationHuman immunodeficiency virus 1-the failure of an HIV protease inhibitor to fit within the substrate envelope appears to correlate with its susceptibility to mutational resistance682765-
additional informationHuman immunodeficiency virus 1-computational techniques to improve binding affinity are successfully applied to design peptide sequences that bind tighter to inactivated (D25N) HIV-1 protease682770-
additional informationHuman immunodeficiency virus 1-identification of the native pose of HIV-1 protease inhibitors by quantum mechanical/molecular mechanical models and comparison with the AMBER force field and ChemScore and GoldScore scoring functions. For the discrimination of native from non-native poses, solvent-corrected HF/6-31G:AMBER and AMBER functions exhibit the best overall performance. The electrostatic component of the MM and QM/MM functions appears important for discriminating the native pose of the ligand. There is no advantage to binding mode prediction by incorporating active site polarization at the PM3-D level. Choice of the protonation state of the aspartyl dyad in the HIV-1 protease active site influences the ability of scoring methods to determine the native binding pose699145-

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
transglutaminaseHuman immunodeficiency virus 1-incubation of HIV-1 aspartyl protease with transglutaminase increases its catalytic activity in a time- and concentration-dependent manner. Enzyme activity is increased, up to about 170% of control value, after 1 h incubation with 0.008 units of transglutaminase in the presence of Ca2+. The activation is completely abolished by spermidine717185-
cyclophilinHuman immunodeficiency virus 1-human cyclophilin enhances activity, it is proposed that cyclophilin functions as an auxiliary enzyme for the protease during cleavage in the virion648159-
additional informationHuman immunodeficiency virus 1-casein kinase II is responsible for stimulation of HIV-1 protease in vitro648144-

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.00069-2-aminobenzoyl-TI-Nle-Phe(NO2)-ERHuman immunodeficiency virus 1-pH 5.2, 2.0 M NaCl648156 2D-image
0.00084-2-aminobenzoyl-TI-Nle-Phe(NO2)-ERHuman immunodeficiency virus 1-pH 4.5, 0.1 M NaCl648156 2D-image
0.00598-2-aminobenzoyl-TI-Nle-Phe(NO2)-QRHuman immunodeficiency virus 1-pH 5.0, 2.0 M NaCl648156 2D-image
0.00873-2-aminobenzoyl-TI-Nle-Phe(NO2)-QRHuman immunodeficiency virus 1-pH 4.9, 1.0 M NaCl648156 2D-image
0.0152-2-aminobenzoyl-TI-Nle-Phe(NO2)-QRHuman immunodeficiency virus 1-pH 4.u, 0.1 M NaCl648156 2D-image
0.0021-2-aminobenzoyl-TI-Nle-Phe(NO2)-QR-NH2Human immunodeficiency virus 1-pH 6.0, 25°C648151 2D-image
0.0097-Abz-Ala-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-wild-type, pH 5.5699555-
0.0513-Abz-Ala-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-mutant I84V, pH 5.5699555-
0.117-Abz-Ala-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-mutant I50V, pH 5.5699555-
0.0052-Abz-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-wild-type, pH 5.5699555-
0.0277-Abz-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-I84V, pH 5.5699555-
0.0549-Abz-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-I50V, pH 5.5699555-
0.0227-Abz-Lys-Ala-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-wild-type, pH 5.5699555-
0.072-Abz-Lys-Ala-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-mutant I84V, pH 5.5699555-
0.158-Abz-Lys-Ala-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-mutant I50V, pH 5.5699555-
0.0146-Abz-Thr-Ile-Nle-(p-nitro)Phe-Gln-Arg-NH2Human immunodeficiency virus 1-wild-type, pH 5.5699555-
0.0706-Abz-Thr-Ile-Nle-(p-nitro)Phe-Gln-Arg-NH2Human immunodeficiency virus 1-mutant I84V, pH 5.5699555-
0.139-Abz-Thr-Ile-Nle-(p-nitro)Phe-Gln-Arg-NH2Human immunodeficiency virus 1-mutant I50V, pH 5.5699555-
0.012-Ac-HGWILAEHGD-NH2Human immunodeficiency virus 1-pH 6.0, 37°C648124 2D-image
3.9-Ac-RASQNYPVV-NH2Human immunodeficiency virus 1-pH 6.0, 37°C648124 2D-image
2.1-Ac-RKILFLDG-NH2Human immunodeficiency virus 1-pH 6.0, 37°C648124 2D-image
0.66-Ac-SQNYFLDG-NH2Human immunodeficiency virus 1-pH 6.0, 37°C648124 2D-image
5.5-Ac-SQNYPVV-NH2Human immunodeficiency virus 1-pH 6.0, 37°C648124 2D-image
1.5-Ac-SQSYPVV-NH2Human immunodeficiency virus 1-pH 6.0, 37°C648124 2D-image
1.4-Ac-TIMMQR-NH2Human immunodeficiency virus 1--648120 2D-image
0.032-AETFYVDGAAHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis resistant enzyme form PR with the mutations Q7K/L33I/L63I/C67A/C95A648164 2D-image
0.041-AETFYVDGAAHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis reistant and truncated enzyme form PR-(5-99) with mutation Q7K/L33I/L63I/C67A/C95A648164 2D-image
0.03-aminobenzoyl-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2Human immunodeficiency virus 1--707444-
0.025-Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-ArgHuman immunodeficiency virus 1--707721-
0.044-CTLNFPISPHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis resistant enzyme form PR with the mutations Q7K/L33I/L63I/C67A/C95A648164 2D-image
0.087-CTLNFPISPHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis reistant and truncated enzyme form PR-(5-99) with mutation Q7K/L33I/L63I/C67A/C95A648164 2D-image
0.71-DTV(I)33EEMSHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136-
0.81-DTV(I)33EEMSHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136-
1.02-DTV(L)33EEMSHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136-
1.11-DTV(L)33EEMSHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136-
0.87-DTV(V)33EEMSHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136-
0.95-DTV(V)33EEMSHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136-
0.1-GAETFYVDGAAHuman immunodeficiency virus 1-pH 5.0, 37°C, wild-type enzyme648142 2D-image
0.0098-His-Lys-Ala-Arg-Val-Leu-(p-nitro)-Phe-Glu-Ala-Nle-Ser-amideHuman immunodeficiency virus 1--648134 2D-image
0.07-IPFAAAQQRKHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.28-IPFAAAQQRKHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.016-IRKILFLDGHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis resistant enzyme form PR with the mutations Q7K/L33I/L63I/C67A/C95A648164 2D-image
0.046-IRKILFLDGHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis reistant and truncated enzyme form PR-(5-99) with mutation Q7K/L33I/L63I/C67A/C95A648164 2D-image
0.09-KARLMAEALKHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.13-KARLMAEALKHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.06-KARV-Nle-Phe(NO2)-EA-NleHuman immunodeficiency virus 1-pH 5.0, wild-type enzyme648153 2D-image
0.075-KARV-Nle-Phe(NO2)-EA-NleHuman immunodeficiency virus 1-pH 5.0, mutant enzyme Q7K/L33I/L63I/C67A/C95A648153 2D-image
0.133-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, wild-type enzyme648159 2D-image
0.177-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, mutant enzyme Q7K/L33I/L63I/C67A/C95A648169 2D-image
0.225-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, mutant enzyme Q7K/R8Q/L33I/L63I/C67A/C95A648169 2D-image
0.231-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, mutant enzyme C95A648159 2D-image
0.244-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, mutant enzyme C67A/C95A648159 2D-image
0.263-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, mutant enzyme C67A648159 2D-image
0.278-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, wild-type enzyme648169 2D-image
0.66-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, truncated version PR-(5-99) from mutant enzyme Q7K/L33I/L63I/C67A/C95A648169 2D-image
0.021-KARVLAEAMSHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis resistant enzyme form PR with the mutations Q7K/L33I/L63I/C67A/C95A648164 2D-image
0.192-KARVLAEAMSHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis reistant and truncated enzyme form PR-(5-99) with mutation Q7K/L33I/L63I/C67A/C95A648164 2D-image
6.4-KLRPGNFLQSRPHuman immunodeficiency virus 1-pH 5.0, 37°C, wild-type enzyme648142, 648148 2D-image
0.044-Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amideHuman immunodeficiency virus 1-pH 5.0, mutant V82A666016 2D-image
0.046-Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amideHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant G73S666063 2D-image
0.055-Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amideHuman immunodeficiency virus 1-pH 5.0, mutant Q7K/L33I/L63I/C67A/C95A666016 2D-image
0.211-Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amideHuman immunodeficiency virus 1-pH 5.0, mutant I84V666016 2D-image
0.31-Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amideHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant L24I666063 2D-image
0.5-Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amideHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant I50V666063 2D-image
0.01-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant L90M678346 2D-image
0.016-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant N88D678346 2D-image
0.017-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype C protease678346 2D-image
0.019-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease D30N/N88D678346 2D-image
0.0195-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease678346 2D-image
0.022-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant N88D678346 2D-image
0.023-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease D30N/L90M; 37°C, pH 4.7, HIV-1 subtype B protease mutant L90M678346 2D-image
0.024-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease N88D/L90M678346 2D-image
0.03-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease N88D/L90M678346 2D-image
0.035-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant 0.061 D30N/N88D678346 2D-image
0.0386-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant D30N678346 2D-image
0.061-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant 0.03 D30M/L90M678346 2D-image
0.064-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype C protease mutant D30N678346 2D-image
0.006-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme N88D681460 2D-image
0.011-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme L90M681460 2D-image
0.014-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme A71V681460 2D-image
0.015-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, wild-type enzyme681460 2D-image
0.018-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme D30N; 37°C, pH 4.7, mutant enzyme D30N/N88D681460 2D-image
0.024-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme D30N/A71V681460 2D-image
0.027-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme D30N/L63PA71V/L90M681460 2D-image
0.007-PAFVLAEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
0.009-PAFVLAEAMRHuman immunodeficiency virus 1-mutant enzyme I84V; wild-type enzyme648138-
0.01-PAFVLAEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
0.013-PAFVLAEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
0.027-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M648138-
0.033-PARVLAEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
0.046-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme V82T648138-
0.051-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
0.056-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
0.072-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
0.105-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
0.013-PARVLFEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
0.02-PARVLFEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
0.025-PARVLFEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M648138-
0.027-PARVLFEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
0.033-PARVLFEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
0.046-PARVLFEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
0.057-PARVLFEAMRHuman immunodeficiency virus 1-mutant enzyme V82T648138-
0.023-PARVLIEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
0.027-PARVLIEAMRHuman immunodeficiency virus 1-mutant enzyme V82T648138-
0.054-PARVLIEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
0.071-PARVLIEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
0.09-PARVLIEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M648138-
0.108-PARVLIEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
0.129-PARVLIEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
0.061-PARVLLAEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
0.03-PARVLLEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M648138-
0.031-PARVLLEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
0.033-PARVLLEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
0.034-PARVLLEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
0.061-PARVLLEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
0.07-PARVLLEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
0.024-PARVLMEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M; mutant enzyme R8K648138-
0.032-PARVLMEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
0.033-PARVLMEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
0.036-PARVLMEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
0.01-PARVLVEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M648138-
0.014-PARVLVEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
0.015-PARVLVEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
0.016-PARVLVEAMRHuman immunodeficiency virus 1-mutant enzyme V82T648138-
0.024-PARVLVEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
0.044-PARVLVEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
0.1-PARVLVEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
2.2-PQITLLLLLWQRPHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136 2D-image
0.143-REYDQI(I)63IEVSHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136-
0.152-REYDQI(I)63IEVSHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136-
0.202-REYDQI(L)63IEVSHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136-
0.215-REYDQI(L)63IEVSHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136-
0.125-REYDQI(L)63IKVSHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136-
0.135-REYDQI(L)63IKVSHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136-
0.34-RQGTVSFNFPQITLHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme A28S648142, 648148, 648171 2D-image
0.54-RQGTVSFNFPQITLHuman immunodeficiency virus 1-pH 5.0, 37°C, wild-type enzyme648142, 648148, 648171 2D-image
0.24-TATIMMQRGNHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme A28S648171 2D-image
0.5-TATIMMQRGNHuman immunodeficiency virus 1-pH 5.0, 37°C, wild-type enzyme648142 2D-image
0.32-VLQNYPIVQHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.4-VLQNYPIVQHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.12-VSQLYPIVQHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.38-VSQLYPIVQHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
2-VSQNYPIVHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme and mutant enzyme Q7K/L33I/L63I648136 2D-image
1.15-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme L90M648142, 648148 2D-image
1.5-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, wild-type enzyme648142, 648148 2D-image
3.3-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme G48H648148 2D-image
3.8-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme G48V/L90M648142, 648148 2D-image
4.2-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme V82A648148 2D-image
9.8-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme G48V648142 2D-image
0.24-VSQVYPIVQHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.35-VSQVYPIVQHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.19-VVQNYPIVQHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.23-VVQNYPIVQHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.064-YVSQNFPIVQNRHuman immunodeficiency virus 1-pH 4.7665102 2D-image
0.029-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme D30N/L90M681460 2D-image
additional information-additional informationHuman immunodeficiency virus 1-kinetics, LAI wild-type enzyme664013-
additional information-additional informationHuman immunodeficiency virus 1--665102-
additional information-additional informationHuman immunodeficiency virus 1-substrate specificity and kinetics of wild-type and mutant enzymes, overview666063-
additional information-additional informationHuman immunodeficiency virus 1P04587-666190-
additional information-additional informationHuman immunodeficiency virus 1-molecular dynamics technique simulation of pH effecting the enzyme dynamics, effects of Na+ and Cl- ions, overview666873-

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
4.14-2-aminobenzoyl-TI-Nle-Phe(NO2)-ERHuman immunodeficiency virus 1-pH 5.2, 2.0 M NaCl648156 2D-image
5.46-2-aminobenzoyl-TI-Nle-Phe(NO2)-ERHuman immunodeficiency virus 1-pH 4.5, 0.1 M NaCl648156 2D-image
5.8-2-aminobenzoyl-TI-Nle-Phe(NO2)-QRHuman immunodeficiency virus 1-pH 4.8, 0.1 M NaCl648156 2D-image
9.25-2-aminobenzoyl-TI-Nle-Phe(NO2)-QRHuman immunodeficiency virus 1-pH 4.9, 1.0 M NaCl648156 2D-image
19.5-2-aminobenzoyl-TI-Nle-Phe(NO2)-QRHuman immunodeficiency virus 1-pH 5.0, 2.0 M NaCl648156 2D-image
7.4-2-aminobenzoyl-TI-Nle-Phe(NO2)-QR-NH2Human immunodeficiency virus 1-pH 6.0, 25°C648151 2D-image
0.0008-AETFYVDGAAHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis reistant and truncated enzyme form PR-(5-99) with mutation Q7K/L33I/L63I/C67A/C95A648164 2D-image
0.41-AETFYVDGAAHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis resistant enzyme form PR with the mutations Q7K/L33I/L63I/C67A/C95A648164 2D-image
0.05-CTLNFPISPHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis reistant and truncated enzyme form PR-(5-99) with mutation Q7K/L33I/L63I/C67A/C95A648164 2D-image
1.72-CTLNFPISPHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis resistant enzyme form PR with the mutations Q7K/L33I/L63I/C67A/C95A648164 2D-image
0.04-DTV(I)33EEMSHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136-
0.0483-DTV(I)33EEMSHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136-
4.35-DTV(L)33EEMSHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136-
4.58-DTV(L)33EEMSHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136-
0.125-DTV(V)33EEMSHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136-
0.13-DTV(V)33EEMSHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136-
5.05-GAETFYVDGAAHuman immunodeficiency virus 1-pH 5.0, 37°C, wild-type enzyme648142 2D-image
0.3-IPFAAAQQRKHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
1.2-IPFAAAQQRKHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.08-IRKILFLDGHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis reistant and truncated enzyme form PR-(5-99) with mutation Q7K/L33I/L63I/C67A/C95A648164 2D-image
1.2-IRKILFLDGHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis resistant enzyme form PR with the mutations Q7K/L33I/L63I/C67A/C95A648164 2D-image
0.3-KARLMAEALKHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.6-KARLMAEALKHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.767-KARV-Nle-Phe(NO2)-EA-NleHuman immunodeficiency virus 1-pH 5.0, mutant enzyme Q7K/L33I/L63I/C67A/C95A648153 2D-image
1.23-KARV-Nle-Phe(NO2)-EA-NleHuman immunodeficiency virus 1-pH 5.0, wild-type enzyme648153 2D-image
0.44-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, truncated version PR-(5-99) from mutant enzyme Q7K/L33I/L63I/C67A/C95A648169 2D-image
1.9-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, wild-type enzyme648159 2D-image
3.5-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, mutant enzyme C67A/C95A and mutant enzyme C95A648159 2D-image
3.7-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, mutant enzyme C67A648159 2D-image
3.74-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, wild-type enzyme648169 2D-image
5.2-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, mutant enzyme Q7K/R8Q/L33I/L63I/C67A/C95A648169 2D-image
5.5-KARV-Nle-Phe(NO2)-EA-Nle-NH2Human immunodeficiency virus 1-pH 5.0, 25°C, mutant enzyme Q7K/L33I/L63I/C67A/C95A648169 2D-image
0.11-KARVLAEAMSHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis reistant and truncated enzyme form PR-(5-99) with mutation Q7K/L33I/L63I/C67A/C95A648164 2D-image
0.89-KARVLAEAMSHuman immunodeficiency virus 1-pH 5.6, 37°C, autolysis resistant enzyme form PR with the mutations Q7K/L33I/L63I/C67A/C95A648164 2D-image
12.7-KLRPGNFLQSRPHuman immunodeficiency virus 1-pH 5.0, 37°C, wild-type enzyme648142, 648148 2D-image
61-Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amideHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant L24I666063 2D-image
194.5-Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amideHuman immunodeficiency virus 1-pH 5.0, mutant V82A666016 2D-image
280-Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amideHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant G73S666063 2D-image
285-Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amideHuman immunodeficiency virus 1-pH 5.0, mutant Q7K/L33I/L63I/C67A/C95A666016 2D-image
480-Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amideHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant I50V666063 2D-image
780-Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amideHuman immunodeficiency virus 1-pH 5.0, mutant I84V666016 2D-image
3.2-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease D30N/N88D678346 2D-image
3.5-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant D30M/L90M678346 2D-image
4-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease D30N/L90M678346 2D-image
4.3-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant N88D678346 2D-image
4.8-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant L90M678346 2D-image
5-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant D30N678346 2D-image
5.6-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype C protease678346 2D-image
5.8-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant L90M678346 2D-image
10-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease678346 2D-image
10.2-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease N88D/L90M678346 2D-image
12-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant N88D; 37°C, pH 4.7, HIV-1 subtype C protease mutant D30N678346 2D-image
12.4-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease mutant D30N/N88D678346 2D-image
13-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-GlyHuman immunodeficiency virus 1-37°C, pH 4.7, HIV-1 subtype B protease N88D/L90M678346 2D-image
8-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme N88D681460 2D-image
12-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme A71V681460 2D-image
14-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme D30N/A71V681460 2D-image
16-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme D30N/L63PA71V/L90M; 37°C, pH 4.7, mutant enzyme L90M681460 2D-image
17-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme D30N681460 2D-image
22-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme D30N/L90M681460 2D-image
24-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, mutant enzyme D30N/N88D681460 2D-image
30-Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2Human immunodeficiency virus 1-37°C, pH 4.7, wild-type enzyme681460 2D-image
0.0833-PAFVLAEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
0.167-PAFVLAEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
0.183-PAFVLAEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M648138-
0.25-PAFVLAEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
0.317-PAFVLAEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
0.583-PAFVLAEAMRHuman immunodeficiency virus 1-mutant enzyme V82T648138-
0.933-PAFVLMEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
0.0667-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
0.133-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
0.2-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M648138-
0.267-PARVLAEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
0.333-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
0.533-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme V82T648138-
0.75-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
0.9-PARVLAEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
0.467-PARVLFEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
1.03-PARVLFEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
1.1-PARVLFEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
1.15-PARVLFEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M648138-
1.57-PARVLFEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
1.73-PARVLFEAMRHuman immunodeficiency virus 1-mutant enzyme V82T648138-
2.55-PARVLFEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
0.367-PARVLIEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
0.6-PARVLIEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
1.03-PARVLIEAMRHuman immunodeficiency virus 1-mutant enzyme V82T648138-
1.07-PARVLIEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M648138-
1.17-PARVLIEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
1.6-PARVLIEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
1.82-PARVLIEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
0.467-PARVLLEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M648138-
0.583-PARVLLEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
0.617-PARVLLEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
0.633-PARVLLEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
1.22-PARVLLEAMRHuman immunodeficiency virus 1-mutant enzyme V82T648138-
1.6-PARVLLEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
2.22-PARVLLEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
0.6-PARVLMEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
1.02-PARVLMEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M648138-
1.07-PARVLMEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
1.28-PARVLMEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
1.3-PARVLMEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
1.87-PARVLMEAMRHuman immunodeficiency virus 1-mutant enzyme V82T648138-
0.5-PARVLVEAMRHuman immunodeficiency virus 1-mutant enzyme V32I648138-
0.717-PARVLVEAMRHuman immunodeficiency virus 1-mutant enzyme G48V/L90M648138-
0.833-PARVLVEAMRHuman immunodeficiency virus 1-wild-type enzyme648138-
1.23-PARVLVEAMRHuman immunodeficiency virus 1-mutant enzyme R8K648138-
1.32-PARVLVEAMRHuman immunodeficiency virus 1-mutant enzyme V82T/I84V648138-
2-PARVLVEAMRHuman immunodeficiency virus 1-mutant enzyme V82T648138-
2.02-PARVLVEAMRHuman immunodeficiency virus 1-mutant enzyme I84V648138-
0.0967-PQITLLLLLWQRPHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136 2D-image
0.103-PQITLLLLLWQRPHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136 2D-image
0.025-REYDQI(I)63IEVSHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136-
0.0267-REYDQI(I)63IEVSHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136-
2.85-REYDQI(L)63IEVSHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136-
3.07-REYDQI(L)63IEVSHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136-
0.000833-REYDQI(L)63IKVSHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136-
0.001-REYDQI(L)63IKVSHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136-
0.026-RQGTVSFNFPQITLHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme A28S648171 2D-image
62.7-RQGTVSFNFPQITLHuman immunodeficiency virus 1-pH 5.0, 37°C, wild-type enzyme648142, 648148, 648171 2D-image
0.018-TATIMMQRGNHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme A28S648142, 648171 2D-image
58.8-TATIMMQRGNHuman immunodeficiency virus 1-pH 5.0, 37°C, wild-type enzyme648142, 648171 2D-image
0.06-VLQNYPIVQHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.26-VLQNYPIVQHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.4-VSQLYPIVQHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
5.1-VSQLYPIVQHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
4.02-VSQNYPIVHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136 2D-image
4.32-VSQNYPIVHuman immunodeficiency virus 1-pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I648136 2D-image
0.08-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme I84V648148 2D-image
0.172-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme V82E648148 2D-image
2.2-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme G48V/L90M648142, 648148 2D-image
3.14-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme L90M648142, 648148 2D-image
9.7-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme I82V648148 2D-image
19.2-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme A28S648148 2D-image
20.7-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme V82A648148 2D-image
30.9-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme V82E648148 2D-image
31.3-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme G48V648142, 648148 2D-image
51.8-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, wild-type enzyme648142, 648148 2D-image
93.5-VSQNYPIVQHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme G48H648148 2D-image
2.6-VSQVYPIVQHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
3-VSQVYPIVQHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.16-VVQNYPIVQHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
0.18-VVQNYPIVQHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
1.1-IPFAAAQQRKHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370235548
16.3-IPFAAAQQRKHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370235548
2.3-KARLMAEALKHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370320415
6.6-KARLMAEALKHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370320415
0.2-VLQNYPIVQHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370146964
0.8-VLQNYPIVQHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370146964
3.3-VSQLYPIVQHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370200206
8.6-VSQLYPIVQHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370200206
8.6-VSQVYPIVQHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370200242
10.8-VSQVYPIVQHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370200242
0.8-VVQNYPIVQHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C; wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370200254

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.00011-((S)-1-(N'-(3',5'-difluoro-biphenyl-4-ylmethyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxyindan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-wild-type protein709481-
1.8e-06-((S)-1-(N'-(4'-acetylamino-biphenyl-4-ylmethyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethylpropyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-wild-type protein709481-
8e-06-((S)-1-(N'-(4-benzo[1,3]dioxol-5-yl-benzyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxyindan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-wild-type protein709481-
2.3e-06-((S)-1-(N'-benzyl-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-wild-type protein709481-
8.2e-06-((S)-1-(N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-phenethyl-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-wild-type protein709481-
1.7e-06-((S)-1-(N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-[4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-wild-type protein709481-
2.8e-06-((S)-1-(N'-[4-(3,5-dimethyl-isoxazol-4-yl)-benzyl]-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethylpropyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-wild-type protein709481-
2.9e-06-((S)-1-[N'-(4-bromo-benzyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-wild-type protein709481-
3e-05-((S)-1-[N'-(4-bromo-benzyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-L63P/V82T/I84V mutant protein709481-
1.2e-05-((S)-1-[N'-biphenyl-4-ylmethyl-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-wild-type protein709481-
1.7e-06-((S)-1-[N'-[(S)-3-Hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-wild-type protein709481-
1.6e-05-((S)-1-[N'-[(S)-3-Hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-L63P/V82T/I84V mutant protein709481-
1.2e-06-((S)-1-[N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-(4-pyridin-3-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-wild-type protein709481-
1.6e-05-((S)-1-[N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-(4-pyridin-3-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-L63P/V82T/I84V mutant protein709481-
2.3e-06-((S)-1-[N'-[(S)-3-Hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-(4-pyridin-4-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl esterHuman immunodeficiency virus 1-wild-type protein709481-
0.0006-(1-Benzyl-3-benzylcarbamoyl-3,3-difluoro-2-oxo-propyl)-carbamic acid benzyl esterHuman immunodeficiency virus 1--648128 2D-image
5.3e-05-(2E)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]propyl]-4,4,4-trifluoro-3-methylbut-2-enamideHuman immunodeficiency virus 1--680381 2D-image
0.00061-(2E)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]propyl]-4-oxopent-2-enamideHuman immunodeficiency virus 1--680381 2D-image
0.013-(2E)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(5-methylisoxazol-4-yl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-4,4,4-trifluoro-3-methylbut-2-enamideHuman immunodeficiency virus 1--680381 2D-image
3.8e-07-(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamideHuman immunodeficiency virus 1--681109 2D-image
2.12e-05-(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R,5S)-2-hydroxy-5-methylcyclopentyl]amino]-5-oxopentyl]-N-tert-butyl-4-(3-pyridin-3-ylpropanoyl)piperazine-2-carboxamideHuman immunodeficiency virus 1--681109 2D-image
1.9e-06-(2S)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1--680381 2D-image
2.5e-06-(2S)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1--680381 2D-image
6.2e-07-(2S)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1--680381 2D-image
2.9e-07-(2S)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1--680381 2D-image
8.2e-07-(2S)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]-2,3-dimethylbutanamideHuman immunodeficiency virus 1--680381 2D-image
6.3e-08-(2S)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1--680381 2D-image
4e-09-(2S)-N-[(1S,2R,3S,4S)-1-benzyl-2,3-dihydroxy-4-[[(2S)-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanoyl]amino]-5-phenylpentyl]-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamideHuman immunodeficiency virus 1--681109 2D-image
1.12e-07-(2S)-N-[(1S,2S,4S)-1-benzyl-2-hydroxy-4-[[(2S)-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanoyl]amino]-5-phenylpentyl]-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamideHuman immunodeficiency virus 1--681109 2D-image
6.3e-08-(2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1-wild-type protein709749-
8.8e-07-(2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
1.1e-06-(2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
1.3e-06-(2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1-I50V/A71V mutant protein709749-
5e-06-(2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
1.1e-08-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide)Human immunodeficiency virus 1--681109 2D-image
1.2e-08-(2S,2'S)-N,N'-[(2S,3S,4S,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide)Human immunodeficiency virus 1--681109 2D-image
6e-06-(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-dicyclohexylhexane-3,4-diolHuman immunodeficiency virus 1-native enzyme681326 2D-image
1.2e-05-(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-dicyclohexylhexane-3,4-diolHuman immunodeficiency virus 1-mutant enzyme V82A681326 2D-image
1.3e-06-(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-diphenylhexane-3,4-diolHuman immunodeficiency virus 1-native enzyme681326 2D-image
9e-06-(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-diphenylhexane-3,4-diolHuman immunodeficiency virus 1-mutant enzyme V82A681326 2D-image
2.3e-06-(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-6-cyclohexyl-1-phenylhexane-3,4-diolHuman immunodeficiency virus 1-native enzyme681326 2D-image
1.4e-05-(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-6-cyclohexyl-1-phenylhexane-3,4-diolHuman immunodeficiency virus 1-mutant enzyme V82A681326 2D-image
4.5e-06-(2S,4S)-2-[(1R)-2-(benzylamino)-2-oxo-1-[(phenylacetyl)amino]ethyl]-N-[(1S)-1-hydroxy-2-phenylethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--681109 2D-image
1.1e-07-(2S,4S)-N-[(1R,2R)-4-[(1H-benzimidazol-2-ylmethyl)amino]-1-benzyl-2-hydroxy-4-oxobutyl]-2-[(1R)-1-(benzylcarbamoyl)-3-oxo-4-phenylbutyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--681109 2D-image
5.3e-05-(2Z)-4,4,4-trifluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-3-methylbut-2-enamideHuman immunodeficiency virus 1-wild-type protein709749-
0.00013-(2Z)-4,4,4-trifluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-3-methylbut-2-enamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
0.00014-(2Z)-4,4,4-trifluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-3-methylbut-2-enamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
0.00067-(2Z)-4,4,4-trifluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-3-methylbut-2-enamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
6.8e-08-(3aR,4R,7aS)-hexahydro-2H-furo[2,3-b]pyran-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
9e-06-(3aR,4S,7aR)-octahydro-1H-inden-4-yl-(2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
5e-09-(3aR,4S,7aR)-octahydrobenzofuran-4-yl (2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
6.5e-07-(3aR,5r,6aS)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
8.5e-08-(3aS,4S,7aR)-hexahydro-2H-furo[2,3-b]pyran-4-yl (2S,3R)-3-hydroxy-4-(4-(hydroxymethyl)-N-isobutylphenylsulfonamido)-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
1e-08-(3aS,4S,7aR)-hexahydro-2H-furo[2,3-b]pyran-4-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
2.7e-09-(3aS,4S,7aR)-hexahydro-2H-furo[2,3-b]pyran-4-yl-(2S,3R)-4-(N-isobutyl-4-methoxyphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
2.9e-07-(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
9.9e-08-(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((R)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1-GRL-02031709443-
3.1e-07-(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate, (3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl-(2S,3R)-4-(4-amino-N-(((R)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
1.27e-06-(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl-(2S,3R)-4-(4-amino-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
1.1e-07-(3aS,5R,7aR)-hexahydro-2H-furo[2,3-b]pyran-5-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
3.7e-07-(3R)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]-3-hydroxypentanamideHuman immunodeficiency virus 1--680381 2D-image
8.6e-07-(3R)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]-3-hydroxypentanamideHuman immunodeficiency virus 1--680381 2D-image
3.4e-07-(3R)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]-3-hydroxypentanamideHuman immunodeficiency virus 1--680381 2D-image
0.012-(3R)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(5-methylisoxazol-4-yl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-3-methylpent-4-enamideHuman immunodeficiency virus 1--680381 2D-image
1.3e-07-(3R)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]-3-hydroxypentanamideHuman immunodeficiency virus 1--680381 2D-image
7e-07-(3R)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]-3-hydroxypentanamideHuman immunodeficiency virus 1--680381 2D-image
6.7e-08-(3R)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]-3-hydroxypentanamideHuman immunodeficiency virus 1--680381 2D-image
2.5e-06-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
3.1e-07-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3S)-3-hydroxy-4-[(4R)-4-[[4-(hydroxymethyl)-2-methylbenzyl]carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
1.01e-06-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3S)-4-[(4R)-4-[(4-amino-2-methylbenzyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
5.2e-09-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1-GRL-0355707692-
2.03e-06-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
8.5e-07-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
2.8e-07-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(2S,3R)-4-(4-amino-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((R)-2-oxooxazolidin-4-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
1.2e-07-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((R)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2ylcarbamateHuman immunodeficiency virus 1--709443-
3.5e-08-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-2-oxooxazolidin-4-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
3.1e-07-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-4-(4-amino-N-(((R)-2-oxooxazolidin-4-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
8.5e-07-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-4-(4-amino-N-(((R)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
2.4e-07-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-4-(4-amino-N-(((S)-2-oxooxazolidin-4-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamateHuman immunodeficiency virus 1--709443-
2e-06-(3R,4aR,8aR)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-(phenylsulfanyl)butyl]decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--681109 2D-image
1.91e-05-(3R,4S,5S,6S)-2,7-dibenzyl-3,6-bis(phenoxymethyl)-1,2,7-thiadiazepane-4,5-diol 1,1-dioxideHuman immunodeficiency virus 1--681109 2D-image
8.62e-05-(3S)-tetrahydrofuran-3-yl [(2S,3R)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
2.1e-07-(3S)-tetrahydrofuran-3-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
4.1e-08-(4R)-3-[(2S,3S)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--681109 2D-image
5.5e-09-(4R)-N-tert-butyl-3-[(2S,3S)-3-([(2,6-dimethylphenoxy)acetyl]amino)-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--681109 2D-image
1.22e-05-(4R,5S,6S,7S)-1,3-dibenzyl-5,6-dihydroxy-4,7-bis(phenoxymethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--681109 2D-image
1.43e-06-(4S,4aR,7aS)-octahydrocyclopenta[b]pyran-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
5.3e-06-(4S,4aS,7aR)-hexahydro-2H-furo[3,4-b]pyran-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
7.8e-07-(5R)-1,3-dioxepan-5-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamateHuman immunodeficiency virus 1--707692-
6.3e-08-(5S)-3-(2,4-difluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.054e-05-(5S)-3-(2,4-difluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.12e-07-(5S)-3-(2,4-difluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
3.3e-07-(5S)-3-(3,4-difluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
8e-10-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild-type protein709749-
3.9e-08-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
1.6e-07-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
1.4e-06-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-I50V/A71V mutant protein709749-
3.4e-06-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
2.36e-07-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
6e-09-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild-type protein709749-
2.4e-07-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
7.2e-07-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
2.3e-06-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-I50V/A71V mutant protein709749-
3.5e-06-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
1.5e-08-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.69e-06-(5S)-3-(3-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2e-08-(5S)-3-(3-aminophenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.68e-06-(5S)-3-(3-aminophenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.13e-07-(5S)-3-(3-aminophenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
6.55e-06-(5S)-3-(3-aminophenyl)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
3.19e-07-(5S)-3-(3-fluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
4e-09-(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild-type protein709749-
1.8e-07-(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
7.8e-07-(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
1e-06-(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-I50V/A71V mutant protein709749-
1.9e-06-(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
3.17e-07-(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
7.3e-08-(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.04e-06-(5S)-3-(4-acetylphenyl)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.28e-07-(5S)-3-(4-fluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
9.57e-06-(5S)-3-(4-fluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.07e-07-(5S)-3-(4-fluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
9.56e-06-(5S)-3-(4-fluorophenyl)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.22e-07-(5S)-3-[3-(acetylamino)phenyl]-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
3.89e-06-(5S)-3-[3-(acetylamino)phenyl]-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
5.1e-08-(5S)-3-[3-(acetylamino)phenyl]-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
4.76e-06-(5S)-3-[3-(acetylamino)phenyl]-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
8.6e-08-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.45e-06-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.3e-07-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.63e-05-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
6e-09-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild-type protein709749-
2.7e-07-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
1e-06-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
4.2e-06-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-I50V/A71V mutant protein709749-
7.4e-06-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
5.65e-06-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-3-(2-hydroxyphenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
6.734e-05-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-3-(2-hydroxyphenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.36e-07-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-3-(3-nitrophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
5.4e-06-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-3-(3-nitrophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
4.9e-08-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-3-[3-(methylsulfonyl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.74e-06-(5S)-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-3-[3-(methylsulfonyl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.52e-07-(5S)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.35e-07-(5S)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
4.57e-06-(5S)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.86e-07-(5S)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
7.49e-06-(5S)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.96e-07-(5S)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.015e-05-(5S)-N-[(2S,3R)-3-hydroxy-4-[[[4-(hydroxymethyl)phenyl]sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.06e-07-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
5.5e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.42e-07-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
4.36e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.39e-07-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.06e-05-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.6e-08-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild-type protein709749-
5.9e-07-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
2.1e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
7.7e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
1.25e-05-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-I50V/A71V mutant protein709749-
3.47e-07-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2,4-difluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.47e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2-hydroxyphenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.17e-07-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(3-nitrophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
6.48e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(3-nitrophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.67e-07-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(4-fluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.078e-05-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(4-fluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.5e-08-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-[3-(methylsulfonyl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
4.16e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-[3-(methylsulfonyl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
3.3e-08-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.21e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
9.7e-08-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.86e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.6e-08-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
3.38e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.6e-08-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.96e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.5e-07-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2,4-difluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
3.5e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2,4-difluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.32e-07-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(3,4-difluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
5.18e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(3,4-difluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
8e-08-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(3-fluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.12e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(3-fluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.33e-07-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(4-fluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
3e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(4-fluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
3e-09-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-[3-(methylsulfonyl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.45e-06-(5S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-[3-(methylsulfonyl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.36e-07-(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
5.71e-06-(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[2-(trifluoromethyl)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.25e-07-(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
9.95e-06-(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-3-[3-(trifluoromethoxy)phenyl]-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
3.85e-07-(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2,4-difluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
7.36e-06-(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2-hydroxyphenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
4.046e-05-(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2-hydroxyphenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
4.48e-07-(5S)-N-[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(4-fluorophenyl)-2-oxo-1,3-oxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
7.5e-09-(hydroxyetyhl)amide isostereHuman immunodeficiency virus 1--665102-
0.461-(R)-1-benzyl-3-(1-benzyl-2-oxo-ethyl)-1-piperidin-1-yl-ureaHuman immunodeficiency virus 1--707721-
7e-08-(R)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(3,4-methylenedioxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
1.34e-07-(R)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(3-methoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
1.52e-07-(R)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(4-ethoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
1.38e-07-(R)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(4-methoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
1.63e-07-(R)-N-(2-methylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(3,4-methylenedioxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
2.55e-07-(R)-N-(2-methylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(3-methoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
3.1e-07-(R)-N-(2-methylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(4-ethoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
3.11e-07-(R)-N-(2-methylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(4-methoxyphenyl)butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamideHuman immunodeficiency virus 1--678616 2D-image
0.0262-(S)-1-benzyl-3-(1-benzyl-2-oxo-ethyl)-1-piperidin-1-yl-ureaHuman immunodeficiency virus 1--707721-
7.5e-07-(S)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(3-methoxyphenyl)-butanoyl]-3,3-dimethylpyrrolidine-2-carboxamideHuman immunodeficiency virus 1--678616 2D-image
8.61e-07-(S)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(4-ethoxyphenyl)-butanoyl]-3,3-dimethylpyrrolidine-2-carboxamideHuman immunodeficiency virus 1--678616 2D-image
8.04e-07-(S)-N-(2,6-dimethylbenzyl)-3-[(2S,3S)-2-hydroxy-3-(3-amino-2-chlorobenzoyl)amino-4-(4-methoxyphenyl)-butanoyl]-3,3-dimethylpyrrolidine-2-carboxamideHuman immunodeficiency virus 1--678616 2D-image
0.0343-(S,S)-1-[1-benzyl-3-(1-benzyl-2-oxo-ethyl)-ureido]-pyrrolidine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1--707721-
0.1486-(S,S,S,S)-1-[1-benzyl-3-(1-benzyl-2-oxo-ethyl)-ureido]-pyrrolidine-2-carboxylic acid [1-(1-tert-butylcarbamoyl-2-methyl-propylcarbamoyl)-2-methyl-butyl]-amideHuman immunodeficiency virus 1--707721-
3e-06-1,3,4,7-tetrabenzyl-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.292-1-(benzyl[[(2S)-1-oxo-3-phenylpropan-2-yl]carbamoyl]amino)-L-prolyl-N-tert-butyl-L-valinamideHuman immunodeficiency virus 1--707721-
0.099-1-[(3R)-3-benzyl-3-([N-[(benzyloxy)carbonyl]-L-valyl]amino)-4-oxobutyl]-L-prolyl-N-tert-butyl-L-valinamideHuman immunodeficiency virus 1--707721-
0.574-1-[(3R)-3-benzyl-3-([N-[(benzyloxy)carbonyl]-L-valyl]amino)-4-oxobutyl]-N-tert-butyl-L-prolinamideHuman immunodeficiency virus 1--707721-
6e-07-2-[2-[5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-2,6-diphenyl-hexanoylamino]-3-methyl-butyrylamino]-3-methyl-butyric acid methyl esterHuman immunodeficiency virus 1--648125 2D-image
3e-06-2-[2-[5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-2-methyl-6-phenyl-hexanoylamino]-3-methyl-butyrylamino]-3-methyl-butyric acid methyl esterHuman immunodeficiency virus 1--648125 2D-image
1.2e-06-2-[2-[5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-6-phenyl-2-propyl-hexanoylamino]-3-methyl-butyrylamino]-3-methyl-butyric acid methyl esterHuman immunodeficiency virus 1--648125 2D-image
4e-06-2-[2-[5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-6-phenyl-hexanoylamino]-3-methyl-butyrylamino]-3-methyl-butyric acid methyl esterHuman immunodeficiency virus 1--648125 2D-image
5e-05-3,4-dihydroxy-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]benzamideHuman immunodeficiency virus 1-wild-type protein709749-
6.6e-05-3,4-dihydroxy-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]benzamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
0.00014-3,4-dihydroxy-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]benzamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
0.00038-3,4-dihydroxy-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]benzamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
4.2e-05-3-fluoro-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]-2-methylbenzamideHuman immunodeficiency virus 1-wild-type protein709749-
7.9e-05-3-fluoro-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]-2-methylbenzamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
8.5e-05-3-fluoro-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]-2-methylbenzamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
0.00026-3-fluoro-N-[(2S,3R)-3-hydroxy-4-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]-1-phenylbutan-2-yl]-2-methylbenzamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
2.3e-06-3-[3-[2-[2-(ioquinolin-5-yloxy)-acetylamino]-3-methylsulfanyl-propionylamino]-2-methoxy-4-phenyl-butyryl]-5,5-dimethyl-thiazolidine-4-carboxylic acid tert-butylamideHuman immunodeficiency virus 1--648128-
3.6e-05-4,4'-[(3S,4S)-pyrrolidine-3,4-diylbis(benzylsulfamoyl)]dibenzamideHuman immunodeficiency virus 1-mutant I84V, pH 5.5699555 2D-image
0.00026-4,4'-[(3S,4S)-pyrrolidine-3,4-diylbis(benzylsulfamoyl)]dibenzamideHuman immunodeficiency virus 1-wild-type, pH 5.5699555 2D-image
0.0014-4,4'-[(3S,4S)-pyrrolidine-3,4-diylbis(benzylsulfamoyl)]dibenzamideHuman immunodeficiency virus 1-mutant I50V, pH 5.5699555 2D-image
7e-05-4,4'-[(3S,4S)-pyrrolidine-3,4-diylbis[[4-(trifluoromethyl)benzyl]sulfamoyl]]dibenzamideHuman immunodeficiency virus 1-wild-type, pH 5.5699555 2D-image
0.00012-4,4'-[(3S,4S)-pyrrolidine-3,4-diylbis[[4-(trifluoromethyl)benzyl]sulfamoyl]]dibenzamideHuman immunodeficiency virus 1-mutant I84V, pH 5.5699555 2D-image
0.00026-4,4'-[(3S,4S)-pyrrolidine-3,4-diylbis[[4-(trifluoromethyl)benzyl]sulfamoyl]]dibenzamideHuman immunodeficiency virus 1-mutant I50V, pH 5.5699555 2D-image
0.00024-4,7-dibenzyl-1,3-bis(2-chlorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.0011-4,7-dibenzyl-1,3-bis(2-ethoxyethyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
3.4e-05-4,7-dibenzyl-1,3-bis(2-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
3.6e-05-4,7-dibenzyl-1,3-bis(3,3-dimethylbutyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
1.4e-06-4,7-dibenzyl-1,3-bis(3-bromobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
8.9e-07-4,7-dibenzyl-1,3-bis(3-chlorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
3e-06-4,7-dibenzyl-1,3-bis(3-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
2.7e-05-4,7-dibenzyl-1,3-bis(4-bromobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
5.2e-06-4,7-dibenzyl-1,3-bis(4-chlorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
1.4e-06-4,7-dibenzyl-1,3-bis(4-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
1.3e-06-4,7-dibenzyl-1,3-bis(cyclobutylmethyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
3.7e-05-4,7-dibenzyl-1,3-bis(cyclohexylmethyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4.3e-06-4,7-dibenzyl-1,3-bis(cyclopentylmethyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
2.1e-06-4,7-dibenzyl-1,3-bis(cyclopropylmethyl)-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
6e-05-4,7-dibenzyl-1,3-bis[2-(ethenyloxy)ethyl]-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
1.4e-06-4,7-dibenzyl-1,3-dibutyl-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.0001-4,7-dibenzyl-1,3-diethyl-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.00026-4,7-dibenzyl-1,3-diheptyl-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4.6e-06-4,7-dibenzyl-1,3-dihexyl-5,6-dihydroxy-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.00011-4,7-dibenzyl-1-decyl-5,6-dihydroxy-3-nonyl-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.0019-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methoxybenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.00079-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methoxyethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
7.2e-06-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methylprop-2-en-1-yl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4.9e-05-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methylpropyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
1.2e-07-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-hydroxybenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
4.2e-07-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-iodobenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
1.6e-06-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methoxybenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
7.1e-06-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
1.8e-06-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbut-2-en-1-yl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
1.2e-05-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbutyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
2.8e-06-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-nitrobenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
1.2e-07-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-hydroxybenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.00016-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-methoxybenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
5.8e-06-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-methylbenzyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
7.1e-06-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-methylpentyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
3e-05-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(5-methylhexyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
8.5e-05-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(naphthalen-1-ylmethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
3.1e-07-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(naphthalen-2-ylmethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.00014-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(pyridin-2-ylmethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
9.8e-06-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(pyridin-3-ylmethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
8.9e-05-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(pyridin-4-ylmethyl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.0078-4,7-dibenzyl-5,6-dihydroxy-1,3-bis[2-(2-methoxyethoxy)ethyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.004-4,7-dibenzyl-5,6-dihydroxy-1,3-bis[2-(morpholin-4-yl)ethyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
1.4e-07-4,7-dibenzyl-5,6-dihydroxy-1,3-bis[3-(hydroxymethyl)benzyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
2.2e-05-4,7-dibenzyl-5,6-dihydroxy-1,3-bis[3-(trifluoromethyl)benzyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
3.4e-07-4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(hydroxymethyl)benzyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.0017-4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(hydroxymethyl)benzyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
5.1e-05-4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(trifluoromethyl)benzyl]-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
5.2e-06-4,7-dibenzyl-5,6-dihydroxy-1,3-di(prop-2-en-1-yl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
2.2e-05-4,7-dibenzyl-5,6-dihydroxy-1,3-di(prop-2-yn-1-yl)-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.0058-4,7-dibenzyl-5,6-dihydroxy-1,3-dimethyl-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
1.6e-06-4,7-dibenzyl-5,6-dihydroxy-1,3-dipentyl-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
7.9e-06-4,7-dibenzyl-5,6-dihydroxy-1,3-dipropyl-1,3-diazepan-2-oneHuman immunodeficiency virus 1--709579-
0.0016-4-[[(6-[[(4-aminothiophen-2-yl)carbonyl]amino]-1,3-benzoxazol-2-yl)carbonyl]amino]thiophene-2-carboxylic acidHuman immunodeficiency virus 1-wild-type protein707444-
4.5e-06-A-74704Human immunodeficiency virus 1--648125 2D-image
5.2e-06-Ac-His-Gly-Trp-Ile-PSI[N-CH(CH2(CH3)2)-CH(OH)-CH2-CH2-C(O)]-Glu-His-Gly-Asp-NH2Human immunodeficiency virus 1--648125 2D-image
2e-06-Ace-T-I-Nle-r-Nle-Q-RHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant L24I666063 2D-image
2.2e-06-Ace-T-I-Nle-r-Nle-Q-RHuman immunodeficiency virus 1-pH 5.0, 25°C, wild-type enzyme666063 2D-image
3.3e-06-Ace-T-I-Nle-r-Nle-Q-RHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant G73S666063 2D-image
4.1e-05-Ace-T-I-Nle-r-Nle-Q-RHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant I50V666063 2D-image
0.00053-Ace-T-I-Nle-r-Nle-Q-RHuman immunodeficiency virus 1-mutant V82A enzyme664895 2D-image
0.00217-Ace-T-I-Nle-r-Nle-Q-RHuman immunodeficiency virus 1-wild-type enzyme664895 2D-image
0.013-Ace-T-I-Nle-r-Nle-Q-RHuman immunodeficiency virus 1-mutant I84V enzyme664895 2D-image
2e-05-acetyl-pepstatinHuman immunodeficiency virus 1-pH 4.7, competitive versus YVSQNFPIVQNR665102 2D-image
2.1e-08-AG1776Human immunodeficiency virus 1-pH 4.7, 37°C, recombinant LAI wild-type enzyme664013 2D-image
4e-08-AG1776Human immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 wild-type enzyme664013 2D-image
1.9e-07-AG1776Human immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant I54V664013 2D-image
5e-07-AG1776Human immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant M46I664013 2D-image
5.5e-07-AG1776Human immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant I84V664013 2D-image
2.2e-06-AG1776Human immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant M46I/I84V664013 2D-image
5.6e-06-AG1776Human immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant M46I/I54V/I84V664013 2D-image
9.4e-06-AG1776Human immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant I54V/I84V664013 2D-image
2.7e-05-allyl N-[(1R,2S)-1-benzyl-2-hydroxy-3-[(4S)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1lambda6,2-benzothiazepin-2-yl]propyl]carbamateHuman immunodeficiency virus 1-in 50 mM sodium acetate, pH 5.5, 100 mM NaCl, 1 mg/ml bovine serum albumin, at 30°C717976-
1e-07-amprenavirHuman immunodeficiency virus 1-wild-type enzyme680381 2D-image
1e-07-amprenavirHuman immunodeficiency virus 1-wild-type protein709749 2D-image
1.5e-07-amprenavirHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749 2D-image
1.7e-07-amprenavirHuman immunodeficiency virus 1--707512 2D-image
1.7e-07-amprenavirHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
2.1e-07-amprenavirHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749 2D-image
2.9e-07-amprenavirHuman immunodeficiency virus 1-HIV-1 subtype C protease678346 2D-image
3.4e-07-amprenavirHuman immunodeficiency virus 1-I50V/A71V mutant protein709749 2D-image
3.59e-07-amprenavirHuman immunodeficiency virus 1--678616 2D-image
4e-07-amprenavirHuman immunodeficiency virus 1-HIV-1 subtype B protease678346 2D-image
6e-07-amprenavirHuman immunodeficiency virus 1--664605 2D-image
1.4e-06-amprenavirHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749 2D-image
3.24e-06-amprenavirHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
3.36-Arg-Glu-AspHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
0.97-Asp-AspHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
0.14-Asp-Asp-LeuHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
0.043-Asp-Asp-PheHuman immunodeficiency virus 1-25°C, pH 4.4648141 2D-image
0.23-Asp-Glu-LeuHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
0.27-Asp-Leu-Ala-PheHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
9e-09-atazanavirHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749 2D-image
4.6e-08-atazanavirHuman immunodeficiency virus 1-wild-type enzyme680381 2D-image
4.6e-08-atazanavirHuman immunodeficiency virus 1-wild-type protein709749 2D-image
5e-08-atazanavirHuman immunodeficiency virus 1--678616 2D-image
7e-08-atazanavirHuman immunodeficiency virus 1-HIV-1 subtype B protease678346 2D-image
1.3e-07-atazanavirHuman immunodeficiency virus 1-HIV-1 subtype C protease678346 2D-image
3.3e-07-atazanavirHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749 2D-image
4.8e-07-atazanavirHuman immunodeficiency virus 1--707512 2D-image
4.9e-07-atazanavirHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749 2D-image
5e-07-atazanavirHuman immunodeficiency virus 1-wild-type protein709481 2D-image
6.5e-06-atazanavirHuman immunodeficiency virus 1-L63P/V82T/I84V mutant protein709481 2D-image
1.7e-05-ATBIHuman immunodeficiency virus 1-natural ATBI710216-
7.39e-07-compound JHuman immunodeficiency virus 1--678616 2D-image
5e-09-darunavirHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749 2D-image
8e-09-darunavirHuman immunodeficiency virus 1-wild-type enzyme680381 2D-image
8e-09-darunavirHuman immunodeficiency virus 1-wild-type protein709749 2D-image
1e-08-darunavirHuman immunodeficiency virus 1--707512 2D-image
2.5e-08-darunavirHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749 2D-image
4e-08-darunavirHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C; wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
4.1e-08-darunavirHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749 2D-image
3.3e-07-darunavirHuman immunodeficiency virus 1-I50V/A71V mutant protein709749 2D-image
4.2e-07-darunavirHuman immunodeficiency virus 1-wild-type, pH 5.6, 26°C699546 2D-image
1.1e-06-darunavirHuman immunodeficiency virus 1-wild-type protein709481 2D-image
2.2e-06-darunavirHuman immunodeficiency virus 1-mutant I54M, pH 5.6, 26°C699546 2D-image
6e-06-darunavirHuman immunodeficiency virus 1-mutant I54V, pH 5.6, 26°C699546 2D-image
1e-05-darunavirHuman immunodeficiency virus 1-mutant I50V, pH 5.6, 26°C699546 2D-image
3.6e-05-darunavirHuman immunodeficiency virus 1-mutant G48V, pH 5.6, 26°C699546 2D-image
0.5-E-R-Q-A-N-r-F-L-G-K-IHuman immunodeficiency virus 1-above, wild-type enzyme, mutant V82A enzyme, and mutant I84V enzyme664895 2D-image
3.4e-05-ethyl N-[(1R,2S)-1-benzyl-2-hydroxy-3-[(4S)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1lambda6,2-benzothiazepin-2-yl]propyl]carbamateHuman immunodeficiency virus 1-in 50 mM sodium acetate, pH 5.5, 100 mM NaCl, 1 mg/ml bovine serum albumin, at 30°C717976-
0.098-FLREDLAFHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
0.004-ganomycin BHuman immunodeficiency virus 1--709592 2D-image
0.064-GEDLAFHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
3.07-Glu-Asn-LeuHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
0.05-Glu-Asp-LeuHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
0.16-Glu-Asp-Leu-AlaHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
0.025-Glu-Asp-PheHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
0.31-Glu-Glu-LeuHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
2.01-Glu-Lys-PheHuman immunodeficiency virus 1-25°C, pH 4.25648141 2D-image
1.2e-07-indinavirHuman immunodeficiency virus 1-pH 4.7, wild-type enzyme681460 2D-image
1.8e-07-indinavirHuman immunodeficiency virus 1-wild-type enzyme680381 2D-image
1.8e-07-indinavirHuman immunodeficiency virus 1-wild-type protein709749 2D-image
3e-07-indinavirHuman immunodeficiency virus 1-wild-type protein709481 2D-image
4.9e-07-indinavirHuman immunodeficiency virus 1-wild-type699896 2D-image
5.4e-07-indinavirHuman immunodeficiency virus 1-pH 5.0, 25°C, wild-type enzyme666063 2D-image
5.5e-07-indinavirHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant G73S666063 2D-image
7.3e-07-indinavirHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749 2D-image
1.2e-06-indinavirHuman immunodeficiency virus 1-mutant V82A699896 2D-image
1.4e-06-indinavirHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant L24I666063 2D-image
1.8e-06-indinavirHuman immunodeficiency virus 1-HIV-1 subtype B protease678346 2D-image
3.1e-06-indinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant LAI wild-type enzyme664013 2D-image
3.3e-06-indinavirHuman immunodeficiency virus 1-HIV-1 subtype C protease678346 2D-image
3.9e-06-indinavirHuman immunodeficiency virus 1--707512 2D-image
2.1e-05-indinavirHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749 2D-image
2.7e-05-indinavirHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant I50V666063 2D-image
3.4e-05-indinavirHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749 2D-image
6.2e-05-indinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant M46I/I84V664013 2D-image
6.9e-05-indinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 wild-type enzyme664013 2D-image
0.000219-indinavirHuman immunodeficiency virus 1-mutant V82F/I84V699896 2D-image
0.000289-indinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant I84V664013 2D-image
0.000398-indinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant I54V664013 2D-image
0.001963-indinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant M46I664013 2D-image
0.002914-indinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant M46I/I54V/I84V664013 2D-image
0.004235-indinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant I54V/I84V664013 2D-image
2.4e-07-JG-365Human immunodeficiency virus 1--648125 2D-image
6.6e-07-JG365Human immunodeficiency virus 1--648128 2D-image
5e-09-lopinavirHuman immunodeficiency virus 1-wild-type enzyme680381 2D-image
5e-09-lopinavirHuman immunodeficiency virus 1-wild-type protein709749 2D-image
1.6e-08-lopinavirHuman immunodeficiency virus 1--678616 2D-image
1.8e-08-lopinavirHuman immunodeficiency virus 1-pH 4.7, wild-type enzyme681460 2D-image
4e-08-lopinavirHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749 2D-image
5e-08-lopinavirHuman immunodeficiency virus 1--707512 2D-image
1.1e-07-lopinavirHuman immunodeficiency virus 1-HIV-1 subtype B protease678346 2D-image
1.9e-07-lopinavirHuman immunodeficiency virus 1-HIV-1 subtype C protease678346 2D-image
9e-07-lopinavirHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749 2D-image
1.4e-06-lopinavirHuman immunodeficiency virus 1-wild-type protein709481 2D-image
6.1e-06-lopinavirHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749 2D-image
0.002755-methyl (7S,10R,16S)-10-benzyl-13-(4-bromobenzyl)-10-hydroxy-7-isopropyl-17,17-dimethyl-6,9,15-trioxo-2-oxa-5,8,13,14-tetraazaoctadecan-16-ylcarbamateHuman immunodeficiency virus 1-wild-type protein709481-
3.2e-06-methyl (7S,10S,16S)-10-benzyl-13-(4-bromobenzyl)-10-hydroxy-7-isopropyl-17,17-dimethyl-6,9,15-trioxo-2-oxa-5,8,13,14-tetraazaoctadecan-16-ylcarbamateHuman immunodeficiency virus 1-wild-type protein709481-
0.00124-methyl (S)-1-(2-((R)-3-benzyl-3-hydroxy-4-((S)-3-methyl-1-(methylamino)-1-oxobutan-2-ylamino)-4-oxobutyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1-wild-type protein709481-
0.0022-methyl (S)-1-(2-((R)-3-benzyl-4-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-hydroxy-4-oxobutyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1-wild-type protein709481-
2.9e-06-methyl (S)-1-(2-((S)-3-benzyl-3-hydroxy-4-((S)-3-methyl-1-(methylamino)-1-oxobutan-2-ylamino)-4-oxobutyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1-wild-type protein709481-
1.1e-06-methyl (S)-1-(2-((S)-3-benzyl-4-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-hydroxy-4-oxobutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1-wild-type protein709481-
1e-06-methyl (S)-1-(2-((S)-3-benzyl-4-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-hydroxy-4-oxobutyl)-2-(4-(pyridin-3-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1-wild-type protein709481-
2e-06-methyl (S)-1-(2-((S)-3-benzyl-4-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-hydroxy-4-oxobutyl)-2-(4-(pyridin-4-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1-wild-type protein709481-
1.7e-06-methyl (S)-1-(2-((S)-3-benzyl-4-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-hydroxy-4-oxobutyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamateHuman immunodeficiency virus 1-wild-type protein709481-
0.0061-methyl 4-[([6-[([4-[(tert-butoxycarbonyl)amino]thiophen-2-yl]carbonyl)amino]-1,3-benzoxazol-2-yl]carbonyl)amino]thiophene-2-carboxylateHuman immunodeficiency virus 1-wild-type protein707444-
5e-06-methyl [(2S)-1-[2-[(2S)-2-benzyl-2-hydroxy-3-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-3-oxopropyl]-2-[4-(pyridin-3-yl)benzyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamateHuman immunodeficiency virus 1-wild-type protein709481-
2.8e-06-methyl [(2S)-1-[2-[(4R)-4-benzyl-4-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-2-[4-(pyridin-4-yl)benzyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamateHuman immunodeficiency virus 1-wild-type protein709481-
2.89e-07-methyl [3-[(5S)-5-([(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]carbamateHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
3.68e-06-methyl [3-[(5S)-5-([(2S,3R)-4-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]carbamateHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.63e-07-methyl [3-[(5S)-5-[[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]carbamoyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]carbamateHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
0.000178-MVT-101Human immunodeficiency virus 1--648125 2D-image
0.000128-N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(4-amino-N-benzylbenzenesulfonamide)Human immunodeficiency virus 1-mutant I84V, pH 5.5699555 2D-image
0.00027-N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(4-amino-N-benzylbenzenesulfonamide)Human immunodeficiency virus 1-wild-type, pH 5.5699555 2D-image
0.001-N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(4-amino-N-benzylbenzenesulfonamide)Human immunodeficiency virus 1-mutant I50V, pH 5.5699555 2D-image
0.00033-N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(4-iodobenzyl)benzenesulfonamide]Human immunodeficiency virus 1-mutant I84V, pH 5.5699555 2D-image
0.00039-N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(4-iodobenzyl)benzenesulfonamide]Human immunodeficiency virus 1-wild-type, pH 5.5699555 2D-image
0.0014-N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(4-iodobenzyl)benzenesulfonamide]Human immunodeficiency virus 1-mutant I50V, pH 5.5699555 2D-image
0.00046-N-methyl bis-[N-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[(1S,2R)-1,2]-oxazol-3-yl) 2R-benzyl-3-yl propianamide] sulfoximineHuman immunodeficiency virus 1--707740-
0.0024-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]propyl]-2-thiophen-3-ylacetamideHuman immunodeficiency virus 1--680381 2D-image
0.0011-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]propyl]pyridazine-4-carboxamideHuman immunodeficiency virus 1--680381 2D-image
0.00051-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-2,4,5-trifluoro-3-hydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
0.00058-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-2-methylbenzamideHuman immunodeficiency virus 1--680381 2D-image
0.0011-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-3,4,5-trihydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
5e-05-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-3,4-dihydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
4e-05-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(3-methoxyphenyl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-3-fluoro-2-methylbenzamideHuman immunodeficiency virus 1--680381 2D-image
1.3e-07-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]-3-hydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
2.4e-07-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]-4-oxohexanamideHuman immunodeficiency virus 1--680381 2D-image
1.7e-07-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]cyclopropane-1,1-dicarboxamideHuman immunodeficiency virus 1--680381 2D-image
1.5e-06-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]-3-hydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
4.2e-06-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]-4-oxohexanamideHuman immunodeficiency virus 1--680381 2D-image
7.9e-07-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]cyclopropane-1,1-dicarboxamideHuman immunodeficiency virus 1--680381 2D-image
1.2e-07-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]-3-hydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
6.2e-08-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]-4-oxohexanamideHuman immunodeficiency virus 1--680381 2D-image
2.1e-07-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]cyclopropane-1,1-dicarboxamideHuman immunodeficiency virus 1--680381 2D-image
0.000141-N-[(1S,2R)-1-benzyl-3-[(butylsulfonyl)(3-chlorobenzyl)amino]-2-hydroxypropyl]-2,3-dichlorobenzamideHuman immunodeficiency virus 1--680381 2D-image
0.00065-N-[(1S,2R)-1-benzyl-3-[(butylsulfonyl)(3-chlorobenzyl)amino]-2-hydroxypropyl]-2-bromo-3-methylbenzamideHuman immunodeficiency virus 1--680381 2D-image
2.7e-08-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]-3-hydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
1.2e-07-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]-4-oxohexanamideHuman immunodeficiency virus 1--680381 2D-image
1.2e-07-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]cyclopropane-1,1-dicarboxamideHuman immunodeficiency virus 1--680381 2D-image
3.1e-07-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]-3-hydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
1.6e-06-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]-4-oxohexanamideHuman immunodeficiency virus 1--680381 2D-image
2.1e-07-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]cyclopropane-1,1-dicarboxamideHuman immunodeficiency virus 1--680381 2D-image
3.6e-08-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]-3-hydroxybenzamideHuman immunodeficiency virus 1--680381 2D-image
6.3e-08-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]-4-oxohexanamideHuman immunodeficiency virus 1--680381 2D-image
1.3e-07-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]cyclopropane-1,1-dicarboxamideHuman immunodeficiency virus 1--680381 2D-image
6.2e-08-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-phenylbutan-2-yl]-4-oxohexanamideHuman immunodeficiency virus 1-wild-type protein709749-
8.4e-07-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-phenylbutan-2-yl]-4-oxohexanamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
3.5e-06-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-phenylbutan-2-yl]-4-oxohexanamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
5.3e-06-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-phenylbutan-2-yl]-4-oxohexanamideHuman immunodeficiency virus 1-I50V/A71V mutant protein709749-
7e-06-N-[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-phenylbutan-2-yl]-4-oxohexanamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
3.9e-08-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamideHuman immunodeficiency virus 1-wild-type protein709749-
1.2e-07-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
7.24e-07-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamideHuman immunodeficiency virus 1-I50V/A71V mutant protein709749-
1.08e-06-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
1.8e-06-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
4.6e-08-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamideHuman immunodeficiency virus 1-wild-type protein709749-
3.1e-07-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
7.24e-07-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
1.713e-06-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
1.92e-06-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamideHuman immunodeficiency virus 1-I50V/A71V mutant protein709749-
5.8e-05-N-[(2S,3R)-4-[(cyclopropylmethyl)(furan-2-ylsulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamideHuman immunodeficiency virus 1-wild-type protein709749-
0.00013-N-[(2S,3R)-4-[(cyclopropylmethyl)(furan-2-ylsulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
0.0013-N-[(2S,3R)-4-[(cyclopropylmethyl)(furan-2-ylsulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
0.0029-N-[(2S,3R)-4-[(cyclopropylmethyl)(furan-2-ylsulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
2.4e-05-N-[(2S,3R)-4-[(cyclopropylmethyl)[(3-methoxyphenyl)sulfonyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamideHuman immunodeficiency virus 1-wild-type protein709749-
6.3e-05-N-[(2S,3R)-4-[(cyclopropylmethyl)[(3-methoxyphenyl)sulfonyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
0.00036-N-[(2S,3R)-4-[(cyclopropylmethyl)[(3-methoxyphenyl)sulfonyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
0.000372-N-[(2S,3R)-4-[(cyclopropylmethyl)[(3-methoxyphenyl)sulfonyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-N'-methylbutanediamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
5.8e-07-N1-[1-Benzyl-3-(2-tert-butylcarbamoyl-pyrrolidin-1-yl)-2-methoxy-3-oxo-propyl]-2-[2-(naphthalen-1-yloxy)-acetylamino]-succinamideHuman immunodeficiency virus 1--648128 2D-image
3.3e-05-N2-acetyl-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]propyl]-L-alaninamideHuman immunodeficiency virus 1--680381 2D-image
8.4e-08-N2-acetyl-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]-L-valinamideHuman immunodeficiency virus 1--680381 2D-image
3.8e-08-N2-acetyl-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]-L-valinamideHuman immunodeficiency virus 1--680381 2D-image
3.3e-08-N2-acetyl-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]-L-valinamideHuman immunodeficiency virus 1--680381 2D-image
9.9e-08-N2-acetyl-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]-L-valinamideHuman immunodeficiency virus 1--680381 2D-image
1.4e-08-N2-acetyl-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]-L-valinamideHuman immunodeficiency virus 1--680381 2D-image
5.7e-08-N2-acetyl-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]-L-valinamideHuman immunodeficiency virus 1--680381 2D-image
2.9e-05-N2-acetyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-L-alaninamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
3.3e-05-N2-acetyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-L-alaninamideHuman immunodeficiency virus 1-wild-type protein709749-
9.5e-05-N2-acetyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-L-alaninamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
0.00027-N2-acetyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-L-alaninamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
2e-09-N2-acetyl-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-L-valinamideHuman immunodeficiency virus 1-wild-type protein709749-
6.3e-08-N2-acetyl-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-L-valinamideHuman immunodeficiency virus 1-I50V/A71V mutant protein709749-
9.4e-08-N2-acetyl-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-L-valinamideHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749-
1.17e-07-N2-acetyl-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-L-valinamideHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749-
2.27e-07-N2-acetyl-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-L-valinamideHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749-
6e-07-N2-[(2S)-2-[(3R)-5-[(1S)-1-(L-alanylamino)ethyl]-3-benzyl-2,3,6,7-tetrahydro-1H-azepin-1-yl]propanoyl]-N-[(1S,2S,4R)-1-benzyl-2-hydroxy-4-[5-(2-methylpropanoyl)-1H-imidazol-2-yl]-5-phenylpentyl]-L-valinamideHuman immunodeficiency virus 1--681109 2D-image
0.00043-N2-[(2S)-2-[(3R)-5-[(1S)-1-(L-alanylamino)ethyl]-3-benzyl-2,3,6,7-tetrahydro-1H-azepin-1-yl]propanoyl]-N-[(1S,2S,4R)-1-benzyl-2-hydroxy-4-[5-(2-methylpropanoyl)-1H-imidazol-2-yl]-5-phenylpentyl]-L-valinamideHuman immunodeficiency virus 1--681109 2D-image
2e-05-N2-[(2S,4S,5S)-5-(acetylamino)-6-cyclohexyl-4-hydroxy-2-(1-methylethyl)hexanoyl]-L-glutaminyl-L-argininamideHuman immunodeficiency virus 1--681109 2D-image
7e-08-nelfinavirHuman immunodeficiency virus 1-pH 4.7, wild-type enzyme681460 2D-image
2.8e-07-nelfinavirHuman immunodeficiency virus 1-wild-type enzyme680381 2D-image
2.8e-07-nelfinavirHuman immunodeficiency virus 1-wild-type protein709749 2D-image
5.2e-07-nelfinavirHuman immunodeficiency virus 1-wild-type699896 2D-image
9e-07-nelfinavirHuman immunodeficiency virus 1-mutant V82A699896 2D-image
9.31e-07-nelfinavirHuman immunodeficiency virus 1--678616 2D-image
1.2e-06-nelfinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant LAI wild-type enzyme664013 2D-image
1.2e-06-nelfinavirHuman immunodeficiency virus 1--707512 2D-image
1.7e-06-nelfinavirHuman immunodeficiency virus 1-HIV-1 subtype B protease678346 2D-image
2.7e-06-nelfinavirHuman immunodeficiency virus 1-HIV-1 subtype C protease678346 2D-image
3.5e-06-nelfinavirHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749 2D-image
1.5e-05-nelfinavirHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749 2D-image
1.7e-05-nelfinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 wild-type enzyme664013 2D-image
1.9e-05-nelfinavirHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749 2D-image
2.3e-05-nelfinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant I54V664013 2D-image
2.4e-05-nelfinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant I84V664013 2D-image
5.2e-05-nelfinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant M46I/I84V664013 2D-image
5.6e-05-nelfinavirHuman immunodeficiency virus 1-mutant V82F/I84V699896 2D-image
0.000116-nelfinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant M46I664013 2D-image
0.000563-nelfinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant M46I/I54V/I84V664013 2D-image
0.001259-nelfinavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant I54V/I84V664013 2D-image
3.8e-05-PepstatinHuman immunodeficiency virus 1--707721 2D-image
1.4e-06-pepstatin AHuman immunodeficiency virus 1-about, pH 4.7665102 2D-image
0.055-Phe-Asp-Asp-PheHuman immunodeficiency virus 1-25°C, pH 4.4648141-
0.00035-phenyl N-[(1R,2S)-1-benzyl-2-hydroxy-3-[(4S)-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1lambda6,2-benzothiazepin-2-yl]propyl]carbamateHuman immunodeficiency virus 1-in 50 mM sodium acetate, pH 5.5, 100 mM NaCl, 1 mg/ml bovine serum albumin, at 30°C717976-
0.0282-R-P-G-N-F-r-L-Q-S-R-PHuman immunodeficiency virus 1-mutant V82A enzyme664895 2D-image
0.0967-R-P-G-N-F-r-L-Q-S-R-PHuman immunodeficiency virus 1-wild-type enzyme664895 2D-image
0.5-R-P-G-N-F-r-L-Q-S-R-PHuman immunodeficiency virus 1-above, mutant I84V enzyme664895 2D-image
3.5e-06-R-V-L-r-F-E-A-NleHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant L24I666063 2D-image
2.4e-05-R-V-L-r-F-E-A-NleHuman immunodeficiency virus 1-mutant V82A enzyme664895 2D-image
7.5e-05-R-V-L-r-F-E-A-NleHuman immunodeficiency virus 1-wild-type enzyme664895 2D-image
7.5e-05-R-V-L-r-F-E-A-NleHuman immunodeficiency virus 1-pH 5.0, 25°C, wild-type enzyme666063 2D-image
0.00023-R-V-L-r-F-E-A-NleHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant I50V666063 2D-image
0.000275-R-V-L-r-F-E-A-NleHuman immunodeficiency virus 1-mutant I84V enzyme664895 2D-image
0.00033-R-V-L-r-F-E-A-NleHuman immunodeficiency virus 1-pH 5.0, 25°C, mutant G73S666063 2D-image
1.5e-08-ritonavirHuman immunodeficiency virus 1-pH 4.7, wild-type enzyme681460 2D-image
5.5e-08-ritonavirHuman immunodeficiency virus 1-wild-type enzyme680381 2D-image
5.5e-08-ritonavirHuman immunodeficiency virus 1-wild-type protein709749 2D-image
7e-08-ritonavirHuman immunodeficiency virus 1-HIV-1 subtype B protease678346 2D-image
9.8e-08-ritonavirHuman immunodeficiency virus 1--678616 2D-image
2.7e-07-ritonavirHuman immunodeficiency virus 1-HIV-1 subtype C protease678346 2D-image
4.6e-07-ritonavirHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749 2D-image
5e-07-ritonavirHuman immunodeficiency virus 1-wild-type699896 2D-image
7e-07-ritonavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant LAI wild-type enzyme664013 2D-image
7e-07-ritonavirHuman immunodeficiency virus 1--707512 2D-image
8e-07-ritonavirHuman immunodeficiency virus 1-wild-type protein709481 2D-image
1.08e-06-ritonavirHuman immunodeficiency virus 1-mutant V82A699896 2D-image
2.8e-06-ritonavirHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749 2D-image
3e-06-ritonavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 wild-type enzyme664013 2D-image
3e-06-ritonavirHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749 2D-image
6.5e-06-ritonavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant M46I664013 2D-image
1.09e-05-ritonavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant I54V664013 2D-image
1.65e-05-ritonavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant I84V664013 2D-image
3.45e-05-ritonavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant M46I/I84V664013 2D-image
6.24e-05-ritonavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant M46I/I54V/I84V664013 2D-image
9.32e-05-ritonavirHuman immunodeficiency virus 1-pH 4.7, 37°C, recombinant V6 mutant I54V/I84V664013 2D-image
9.7e-05-ritonavirHuman immunodeficiency virus 1-mutant V82F/I84V699896 2D-image
4e-08-saquinavirHuman immunodeficiency virus 1-pH 4.7, wild-type enzyme681460 2D-image
6.5e-08-saquinavirHuman immunodeficiency virus 1-wild-type enzyme680381 2D-image
6.5e-08-saquinavirHuman immunodeficiency virus 1-wild-type protein709749 2D-image
7e-08-saquinavirHuman immunodeficiency virus 1Q7SSE3mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
1.1e-07-saquinavirHuman immunodeficiency virus 1Q7SSE3wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C718370 2D-image
1.38e-07-saquinavirHuman immunodeficiency virus 1--678616 2D-image
2e-07-saquinavirHuman immunodeficiency virus 1-pH 5.0, 37°C, wild-type enzyme648142 2D-image
2e-07-saquinavirHuman immunodeficiency virus 1-wild-type protein709481 2D-image
5.8e-07-saquinavirHuman immunodeficiency virus 1-wild-type, pH 5.6, 26°C699546 2D-image
6e-07-saquinavirHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme G48V648142 2D-image
6.2e-07-saquinavirHuman immunodeficiency virus 1-wild-type699896 2D-image
9.7e-07-saquinavirHuman immunodeficiency virus 1-mutant V82A699896 2D-image
1e-06-saquinavirHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749 2D-image
1.3e-06-saquinavirHuman immunodeficiency virus 1--707512 2D-image
1.6e-06-saquinavirHuman immunodeficiency virus 1-mutant I54M, pH 5.6, 26°C699546 2D-image
2.2e-06-saquinavirHuman immunodeficiency virus 1-HIV-1 subtype B protease678346 2D-image
2.6e-06-saquinavirHuman immunodeficiency virus 1-HIV-1 subtype C protease678346 2D-image
2.7e-06-saquinavirHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme G48V648142 2D-image
5e-06-saquinavirHuman immunodeficiency virus 1-mutant I54V, pH 5.6, 26°C699546 2D-image
1.7e-05-saquinavirHuman immunodeficiency virus 1-mutant G48V, pH 5.6, 26°C699546 2D-image
1.8e-05-saquinavirHuman immunodeficiency virus 1-mutant I50V, pH 5.6, 26°C699546 2D-image
2.9e-05-saquinavirHuman immunodeficiency virus 1-mutant V82F/I84V699896 2D-image
7.8e-05-saquinavirHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749 2D-image
8.37e-05-saquinavirHuman immunodeficiency virus 1-pH 5.0, 37°C, mutant enzyme G48V/L90M648142 2D-image
9e-05-saquinavirHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749 2D-image
2.8e-06-SB-204,144Human immunodeficiency virus 1--648125 2D-image
1.8e-05-SB203386Human immunodeficiency virus 1--648139 2D-image
1.8e-05-SKF 107457Human immunodeficiency virus 1--648125 2D-image
1.5e-06-tert-butoxycarbonyl-Phe-psi[CH2CH2NH]-Phe-Glu-Phe-NH2Human immunodeficiency virus 1-wild-type enzyme665991 2D-image
4.1e-06-tert-butoxycarbonyl-Phe-psi[CH2CH2NH]-Phe-Glu-Phe-NH2Human immunodeficiency virus 1-mutant A71V/V82T/I84V enzyme665991 2D-image
3.3e-05-tert-butoxycarbonyl-Phe-psi[S-CH(OH)CH2NH]-Phe-Gln-Phe-NH2Human immunodeficiency virus 1-wild-type enzyme665991 2D-image
0.001-tert-butoxycarbonyl-Phe-psi[S-CH(OH)CH2NH]-Phe-Gln-Phe-NH2Human immunodeficiency virus 1-mutant A71V/V82T/I84V enzyme665991 2D-image
1.5e-07-tert-butoxycarbonyl-Phe-psi[S-CH(OH)CH2NH]-Phe-Glu-Phe-NH2Human immunodeficiency virus 1-wild-type enzyme665991 2D-image
8.6e-05-tert-butoxycarbonyl-Phe-psi[S-CH(OH)CH2NH]-Phe-Glu-Phe-NH2Human immunodeficiency virus 1-mutant A71V/V82T/I84V enzyme665991 2D-image
2e-08-tert-butoxycarbonyl-Phe-psi[S-CH(OH)CH2]-Phe-Gln-Phe-NH2Human immunodeficiency virus 1-wild-type enzyme665991 2D-image
2.6e-07-tert-butoxycarbonyl-Phe-psi[S-CH(OH)CH2]-Phe-Gln-Phe-NH2Human immunodeficiency virus 1-mutant A71V/V82T/I84V enzyme665991 2D-image
2e-05-tert-butyl N-[(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1lambda6,2-benzothiazepin-2-yl]-2-hydroxypropyl]carbamateHuman immunodeficiency virus 1-in 50 mM sodium acetate, pH 5.5, 100 mM NaCl, 1 mg/ml bovine serum albumin, at 30°C717976-
0.000186-tert-butyl N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(4S)-4-methyl-1,1-dioxo-7-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-1lambda6,-2-benzothiazepin-2-yl]propyl]carbamateHuman immunodeficiency virus 1-in 50 mM sodium acetate, pH 5.5, 100 mM NaCl, 1 mg/ml bovine serum albumin, at 30°C717976-
0.0001-tert-butyl N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(4S)-4-methyl-1,1-dioxo-8-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-1lambda6,-2-benzothiazepin-2-yl]propyl]carbamateHuman immunodeficiency virus 1-in 50 mM sodium acetate, pH 5.5, 100 mM NaCl, 1 mg/ml bovine serum albumin, at 30°C717976-
1.9e-05-tert-butyl N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(4S)-7-methoxy-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1lambda6,2-benzothiazepin-2-yl]propyl]carbamateHuman immunodeficiency virus 1-in 50 mM sodium acetate, pH 5.5, 100 mM NaCl, 1 mg/ml bovine serum albumin, at 30°C717976-
1e-09-tipranavirHuman immunodeficiency virus 1-D30N/L63P/N88D mutant protein709749 2D-image
1.4e-08-tipranavirHuman immunodeficiency virus 1-L10I/G48V/I54V/L63P/V82A mutant protein709749 2D-image
1.9e-08-tipranavirHuman immunodeficiency virus 1--707512 2D-image
3.2e-08-tipranavirHuman immunodeficiency virus 1-L10I/L63P/A71V/G73S/I84V/L90M mutant protein709749 2D-image
8.8e-08-tipranavirHuman immunodeficiency virus 1-wild-type enzyme680381 2D-image
8.8e-08-tipranavirHuman immunodeficiency virus 1-wild-type protein709749 2D-image
1.1e-07-tipranavirHuman immunodeficiency virus 1-HIV-1 subtype C protease678346 2D-image
4e-07-tipranavirHuman immunodeficiency virus 1-HIV-1 subtype B protease678346 2D-image
7e-06-U-71017Human immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136 2D-image
1.1e-05-U-71038Human immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136 2D-image
9e-06-U-79213Human immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136 2D-image
6e-05-U-81749EHuman immunodeficiency virus 1-pH 5.5, 30°C, wild-type enzyme648136 2D-image
0.015-UCSF8Human immunodeficiency virus 1--648125 2D-image
1e-06-UIC-94017Human immunodeficiency virus 1-pH 5.0, mutant Q7K/L33I/L63I/C67A/C95A666016 2D-image
1.3e-06-UIC-94017Human immunodeficiency virus 1-pH 5.0, mutant V82A666016 2D-image
3.2e-06-UIC-94017Human immunodeficiency virus 1-pH 5.0, mutant I84V666016 2D-image
0.0221-V-S-F-N-F-r-P-Q-I-T-K-KHuman immunodeficiency virus 1-wild-type enzyme664895 2D-image
0.0363-V-S-F-N-F-r-P-Q-I-T-K-KHuman immunodeficiency virus 1-mutant V82A enzyme664895 2D-image
0.0466-V-S-F-N-F-r-P-Q-I-T-K-KHuman immunodeficiency virus 1-mutant I84V enzyme664895 2D-image
1e-06-[1-(1-Benzyl-3-benzylcarbamoyl-3,3-difluoro-2-oxo-propylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl esterHuman immunodeficiency virus 1--648128 2D-image
0.07-ATBIHuman immunodeficiency virus 1-recombinant ATBI710216-
additional information-bis-[(L-valine-N-methylamide)-2-phenyl-3-yl-propionamide] sulfideHuman immunodeficiency virus 1-87% inhibition at 0.01 mM707740-
additional information-bis-[(L-valine-N-methylamide)-2-phenyl-3-yl-propionamide] sulfoxideHuman immunodeficiency virus 1-90% inhibition at 0.01 mM707740-
additional information-bis-[(L-valine-N-methylamide)-2-phenyl-3-yl-propionamide] sulfoximineHuman immunodeficiency virus 1-99% inhibition at 0.01 mM707740-
2.5e-06-bis-[[N-(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-2S-phenyl-3-yl-propionamide] sulfoximineHuman immunodeficiency virus 1--707740-
additional information-bis-[[N-(2R)-phenylglycinol]-2-phenyl-3-yl-propionamide] sulfideHuman immunodeficiency virus 1-51% inhibition at 0.01 mM707740-
additional information-bis-[[N-(2R)-phenylglycinol]-2-phenyl-3-yl-propionamide] sulfoxideHuman immunodeficiency virus 1-50% inhibition at 0.01 mM707740-
additional information-bis-[[N-(2R)-phenylglycinol]-2-phenyl-3-yl-propionamide]sulfoximineHuman immunodeficiency virus 1-54% inhibition at 0.01 mM707740-
additional information-bis-[[N-(2S)-phenylglycinol]-2-phenyl-3-yl-propionamide] sulfideHuman immunodeficiency virus 1-41% inhibition at 0.01 mM707740-
additional information-bis-[[N-(2S)-phenylglycinol]-2-phenyl-3-yl-propionamide] sulfoxideHuman immunodeficiency virus 1-47% inhibition at 0.01 mM707740-
additional information-bis-[[N-(2S)-phenylglycinol]-2-phenyl-3-yl-propionamide] sulfoximineHuman immunodeficiency virus 1-87% inhibition at 0.01 mM707740-
4.44e-06-methyl [3-[(5S)-5-[[(2S,3R)-3-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-phenylbutan-2-yl]carbamoyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]carbamateHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
additional information-additional informationHuman immunodeficiency virus 1-kinetic and thermodynamic characterization of HIV-1 protease inhibitors using a biosensor-based method, overview666106-
additional information-additional informationHuman immunodeficiency virus 1-influence of mutations (D30N, N88D, L90M, D30N/L90M, D30N/N88D, N88D/L90M) on Ki-values for ritonavir, indinavir, nelfinavir, saquinavir, amprenavir, lopinavir, atazanavir, tipranavir678346-
additional information-additional informationHuman immunodeficiency virus 1-influence of mutations (D30N, N88D, L90M, A71V, D30N/A71V, D30N/N88D, D30N/L90M, D30N/L63P/A71V/L90M) on the Ki-values for saquinavir, ritonavir, indinavir, nelfinavir, and lopinavir681460-

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.025-(1S)-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-1-(1-[(2S)-1-[(2-ammonioethyl)amino]-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl)-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethanamiHuman immunodeficiency virus 1--707682-
0.072-(1S)-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethanaminiumHuman immunodeficiency virus 1--707682-
0.06-(1S)-2-methyl-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-2-methyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]propan-1-amineHuman immunodeficiency virus 1--707682-
0.131-(1S)-2-methyl-1-[1-[(1S)-2-methyl-1-[1-[(1S)-1-[1-[(1S)-2-methyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]propan-1-amineHuman immunodeficiency virus 1--707682-
0.129-(1S)-2-methyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]propan-1-aminiumHuman immunodeficiency virus 1--707682-
0.078-(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethanaminiumHuman immunodeficiency virus 1--707682-
0.029-(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethanamineHuman immunodeficiency virus 1--707682-
7.9e-07-(2S)-N-[(4S,7S,10S,11R,12R,13S)-10-benzyl-11,12-dihydroxy-4-(naphthalen-1-ylmethyl)-2,2-dioxido-5,8-dioxo-14-phenyl-7-(propan-2-yl)-2l6-thia-3,6,9-triazatetradecan-13-yl]-3-methyl-2-[[(2S)-2-[(methylsulfonyl)amino]-3-(naphthalen-1-yl)propanoyl]amino]butanHuman immunodeficiency virus 1--708383-
2.2e-06-(2S,2'S)-N,N'-[(2R,3R)-2,3-dihydroxybutane-1,4-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
4e-07-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-1,6-bis(1,3-benzodioxol-5-yl)-3,4-dihydroxyhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
1.8e-05-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-1,6-bis(2,4-dimethoxyphenyl)-3,4-dihydroxyhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
2.9e-06-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-bis(4-hydroxyphenyl)hexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
8.5e-07-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
3.2e-06-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
2.2e-05-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-2-hydroxy-3-phenylpropanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
3.4e-07-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(4-methoxybenzyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
5e-07-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3,3-dimethylbutanamide)Human immunodeficiency virus 1--708383-
3e-07-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
4e-07-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]pentanamide)Human immunodeficiency virus 1--708383-
7.9e-07-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(pyridin-4-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
4e-06-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[3-(tert-butylsulfonyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
3.8e-05-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[(naphthalen-1-yloxy)acetyl]amino]butanamide)Human immunodeficiency virus 1--708383-
4e-06-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[3-(pyridin-4-ylsulfonyl)propanoyl]amino]butanamide)Human immunodeficiency virus 1--708383-
1.5e-05-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide)Human immunodeficiency virus 1--708383 2D-image
0.00034-(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis[2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-(1H-imidazol-4-yl)propanamide]Human immunodeficiency virus 1--708383-
0.00014-(2S,2'S)-N,N'-[(3S,4R,5R,6S)-4,5-dihydroxy-1,8-di(pyridin-4-yl)octane-3,6-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
0.00036-(2S,2'S)-N,N'-[(3S,4R,5R,6S)-4,5-dihydroxy-1,8-diphenyloctane-3,6-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
1e-06-(2S,2'S)-N,N'-[(6S,7R,8R,9S)-7,8-dihydroxytetradecane-6,9-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)Human immunodeficiency virus 1--708383-
0.0001-(2S,2'S)-N1,N1'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]butanediamide)Human immunodeficiency virus 1--708383-
1.9e-05-(3aR,4R,7aS)-hexahydro-2H-furo[2,3-b]pyran-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
0.001-(3aR,4S,7aR)-octahydro-1H-inden-4-yl-(2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1-IC50 above 0.001 mM, pH and temperature not specified in the publication717975-
8e-06-(3aR,4S,7aR)-octahydrobenzofuran-4-yl (2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
4.5e-06-(3aS,4S,7aR)-hexahydro-2H-furo[2,3-b]pyran-4-yl (2S,3R)-3-hydroxy-4-(4-(hydroxymethyl)-N-isobutylphenylsulfonamido)-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
6.5e-06-(3aS,4S,7aR)-hexahydro-2H-furo[2,3-b]pyran-4-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
5e-07-(3aS,4S,7aR)-hexahydro-2H-furo[2,3-b]pyran-4-yl-(2S,3R)-4-(N-isobutyl-4-methoxyphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl carbamateHuman immunodeficiency virus 1-pH and temperature not specified in the publication717975-
0.05-(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-(2-phenylethyl)-4-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--697298 2D-image
0.38-(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-isobutyl-3-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--697298 2D-image
0.02-(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-isobutyl-4-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--697298 2D-image
0.47-(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-propyl-4-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--697298 2D-image
1.4e-06-(3R,6S,9S,10R,11R,12S,15S,18R)-3,9,12,18-tetrabenzyl-10,11-dihydroxy-4,7,14,17-tetraoxo-6,15-di(propan-2-yl)-5,8,13,16-tetraazaicosane-1,20-dioic acidHuman immunodeficiency virus 1--708383-
1.5e-05-(3S,4aS,8aS)-2-((2R,3S)-4-(benzo[b]thiophen-2-yl)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)butyl)-N-tert-butyldecahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--709467-
0.004-(3S,4aS,8aS)-N-tert-butyl-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-3-(4-phenylthiophen-2-yl)propyl)decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--709467-
6e-06-(3S,4aS,8aS)-N-tert-butyl-2-((2R,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(4-phenylthiophen-2-yl)butyl)decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--709467-
2.9e-06-(3S,4aS,8aS)-N-tert-butyl-2-((2R,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(thiophen-2-yl)butyl)decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1-wild-type protein, with 1 nM: 34% residual activity of wild-type protein, 97% residual activity of V32I mutant protein and 60% residual activity of V82A mutant protein, with 10 nM: 5% residual activity of wild-type protein and 32% residual activity of V32I mutant protein709467-
0.03-(3S,4aS,8aS)-N-tert-butyl-2-((2R,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(thiophen-2-yl)proyl)decahydroisoquinoline-3-carboxamideHuman immunodeficiency virus 1--709467-
0.0198-(3S,4S)-3-((benzyl[(2-bromo-4,5-dimethoxyphenyl)carbonyl]amino)methyl)-4-(([2-(2,4-dichlorophenyl)ethyl](4-phenylbutanoyl)amino)methyl)pyrrolidiniumHuman immunodeficiency virus 1-IC50 is 0.0198 mM, binding structure analysis, modelling664605 2D-image
0.0221-(3S,4S)-3-((benzyl[(2-bromo-4,5-dimethoxyphenyl)carbonyl]amino)methyl)-4-(([2-(2,4-dichlorophenyl)ethyl][3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]amino)methyl)pyrrolidiniumHuman immunodeficiency virus 1-IC50 is 0.0221 mM, binding structure analysis, modelling664605 2D-image
0.00016-(4-[4-hydroxy-2-oxo-3-[(2-phenylethyl)sulfanyl]-2H-pyran-6-yl]phenoxy)acetic acidHuman immunodeficiency virus 1--708083-
0.0166-(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-L-prolinamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717348-
0.0118-(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(2,5-dimethoxyphenyl)-L-prolinamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717348-
0.013-(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(2-methoxyphenyl)-L-prolinamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717348-
0.0101-(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(3,4,5-trimethoxyphenyl)-L-prolinamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717348-
0.0152-(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(3-methoxyphenyl)-L-prolinamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717348-
1.54e-05-(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(4-methoxyphenyl)-L-prolinamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717348-
0.000139-(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(4-methylphenyl)-L-prolinamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717348-
0.0148-(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-phenyl-L-prolinamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717348-
0.0101-(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-tert-butyl-L-prolinamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717348-
0.001-(4S,4aS,7aR)-hexahydro-2H-furo[3,4-b]pyran-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamateHuman immunodeficiency virus 1-IC50 above 0.001 mM, pH and temperature not specified in the publication717975-
8e-09-(5S)-3-(3-aminophenyl)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)-(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-2-oxooxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.84e-06-(5S)-3-(3-aminophenyl)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)-(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-2-oxooxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
6e-09-(5S)-3-[3-(acetylamino)phenyl]-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)-propyl]-2-oxooxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.83e-06-(5S)-3-[3-(acetylamino)phenyl]-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)-propyl]-2-oxooxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
2.6e-08-(5S)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)-amino]-2-hydroxy-1-((phenylmethyl)propyl)aminocarbonyl]-2-oxo-((3-oxazolidinyl)phenyl)carbamic acid methyl esterHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.87e-06-(5S)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)-amino]-2-hydroxy-1-((phenylmethyl)propyl)aminocarbonyl]-2-oxo-((3-oxazolidinyl)phenyl)carbamic acid methyl esterHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
1.5e-08-(5S)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)-amino]-2-hydroxy-1-(phenylmethyl)propyl]-3-(3-nitrophenyl)-2-oxooxazolidine-5-carboxamideHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
9.3e-07-(5S)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)-amino]-2-hydroxy-1-(phenylmethyl)propyl]-3-(3-nitrophenyl)-2-oxooxazolidine-5-carboxamideHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971-
7.4e-07-(5S,8S,11S,12R,13R,14S,17S)-11,14-dibenzyl-17-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-8-(2-carboxyethyl)-12,13-dihydroxy-2,2-dimethyl-5-(naphthalen-1-ylmethyl)-6,9,16-trioxo-3l6-thia-7,10,15-triazaicosan-20-oic acid 3,3-dioHuman immunodeficiency virus 1--708383-
7.3e-06-(6R)-4-hydroxy-3-[[5-methyl-2-(propan-2-yl)phenyl]sulfanyl]-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.00013-(6R)-4-hydroxy-3-[[5-methyl-2-(propan-2-yl)phenyl]sulfanyl]-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
6.2e-06-(6S)-4-hydroxy-3-[[5-methyl-2-(propan-2-yl)phenyl]sulfanyl]-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.543-(R)-1-benzyl-3-(1-benzyl-2-oxo-ethyl)-1-piperidin-1-yl-ureaHuman immunodeficiency virus 1--707721-
0.0015-(R)-N1-((1R,2R)-3-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2-(1H)-yl)-2-hydroxy-1-(4-phenylthiophen-2-yl)propyl)-2-(quinoline-2-carboxamido)succinamideHuman immunodeficiency virus 1--709467-
6e-07-(R)-N1-((2S,3R)-1-(benzo[b]thiophen-2-yl)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxybutan-2-yl)-2-(quinoline-2-carboxamido)succinamideHuman immunodeficiency virus 1-wild-type protein, with 1 nM: 53% residual activity of wild-type protein, 54% residual activity of V32I mutant protein and 37% residual activity of V82A mutant protein709467-
0.005-(R)-N1-((2S,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-2-hydroxy-1-(thiophen-2-yl)propyl)-2-(quinoline-2-carboxamido)succinamideHuman immunodeficiency virus 1--709467-
1.2e-06-(R)-N1-((2S,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(4-phenylthiophen-2-yl)butan-2-yl)-2-(quinoline-2-carboxamido)succinamideHuman immunodeficiency virus 1--709467-
2.1e-05-(R)-N1-((2S,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(thiophen-2-yl)butan-2-yl)-2-(quinoline-2-carboxamido)succinamideHuman immunodeficiency virus 1--709467-
0.0372-(S)-1-benzyl-3-(1-benzyl-2-oxo-ethyl)-1-piperidin-1-yl-ureaHuman immunodeficiency virus 1--707721-
3e-07-(S,2S,2'S,3R,3'R)-N,N'-((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)bis(2-((S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanamido)-3-hydroxybutanamide), (S,2S,2'S,3R,3'R)-N,N'-((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)bis(2-((S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanamido)-3-methylpentanamide)Human immunodeficiency virus 1--708383-
0.0445-(S,S)-1-[1-benzyl-3-(1-benzyl-2-oxo-ethyl)-ureido]-pyrrolidine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1--707721-
0.169-(S,S,S,S)-1-[1-benzyl-3-(1-benzyl-2-oxo-ethyl)-ureido]-pyrrolidine-2-carboxylic acid [1-(1-tert-butylcarbamoyl-2-methyl-propylcarbamoyl)-2-methyl-butyl]-amideHuman immunodeficiency virus 1--707721-
0.341-1-(benzyl[[(2S)-1-oxo-3-phenylpropan-2-yl]carbamoyl]amino)-L-prolyl-N-tert-butyl-L-valinamideHuman immunodeficiency virus 1--707721-
0.101-1-[(1S)-2-methyl-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-2-methyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-4-(2-phenylethyl)-1H-1,2,3-triazolHuman immunodeficiency virus 1--707682-
0.204-1-[(3R)-3-benzyl-3-([N-[(benzyloxy)carbonyl]-L-valyl]amino)-4-oxobutyl]-L-prolyl-N-tert-butyl-L-valinamideHuman immunodeficiency virus 1--707721-
0.545-1-[(3R)-3-benzyl-3-([N-[(benzyloxy)carbonyl]-L-valyl]amino)-4-oxobutyl]-N-tert-butyl-L-prolinamideHuman immunodeficiency virus 1--707721-
1.3e-07-1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-(4-oxo-4H-chromene-2-carbonyl)-piperazine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 0.13 nM648128 2D-image
1.8e-05-1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-(naphthalen-2-yloxy)-pyrrolidine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 18 nM648128 2D-image
3e-08-1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-(quinoline-8-sulfonyl)-piperazine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 0.03 nM648128 2D-image
4.1e-07-1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-pyridin-3-ylmethyl-piperazine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 0.41 nM648128 2D-image
3.8e-05-1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 38 nM648128 2D-image
8e-05-1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperidine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 80 nM648128 2D-image
0.00035-1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-pyrrolidine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 350 nM648128 2D-image
0.019-2'-([4-[3-(4-bromophenyl)propanoyl]phenyl]acetyl)biphenyl-2-carboxylic acidHuman immunodeficiency virus 1--708083-
8.9e-07-2,3,4,5,5-pentahydroxy-N-[(2S,5S,8S,9R,10R,11S,14S,17S)-8,11,17-tribenzyl-9,10,20,21,22,23,23-heptahydroxy-3,6,13,16,19-pentaoxo-1-phenyl-5,14-di(propan-2-yl)-4,7,12,15,18-pentaazatricosan-2-yl]pentanamideHuman immunodeficiency virus 1--708383-
1.7e-06-2,5-bis[[(2S)-2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-2-cyclohexylacetyl]amino]-1,2,5,6-tetradeoxy-1,6-diphenyl-L-iditolHuman immunodeficiency virus 1--708383-
3e-07-2,5-bis[[(2S)-2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-2-cyclopentylacetyl]amino]-1,2,5,6-tetradeoxy-1,6-diphenyl-L-iditolHuman immunodeficiency virus 1--708383-
2.5e-05-2,6-dimethylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetylHuman immunodeficiency virus 1-IC50: 25 nM648152 2D-image
2.8e-05-2,6-dimethylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-2,6-dimethylphenoxyacetylHuman immunodeficiency virus 1-IC50: 28 nM648152 2D-image
0.0081-2-(2,5-dichlorobenzoyl)-4,5-dihydroxybenzoic acidHuman immunodeficiency virus 1--708083-
0.029-2-(3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl 5-cyclohexylpentanoateHuman immunodeficiency virus 1--708083-
0.0069-2-(4-chlorophenyl)-7-hydroxyquinoline-4-carboxylic acidHuman immunodeficiency virus 1--708083-
0.0102-2-hydroxy-6-pentadecylbenzoic acidHuman immunodeficiency virus 1--694787 2D-image
0.0249-2-hydroxy-6-[(8Z)-pentadec-8-en-1-yl]benzoic acidHuman immunodeficiency virus 1--694787 2D-image
0.009-2-hydroxyphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-2-hydroxyphenoxyacetylHuman immunodeficiency virus 1-IC50: 0.009 mM648152 2D-image
0.007-2-hydroxyphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-2-hydroxyphenoxyacetylHuman immunodeficiency virus 1-IC50: 0.007 mM648152 2D-image
0.017-2-O-acetyldryopteric acid AHuman immunodeficiency virus 1--697300 2D-image
0.0108-2-O-acetyldryopteric acid BHuman immunodeficiency virus 1--697300 2D-image
0.0178-2-[(10Z)-heptadec-10-en-1-yl]-6-hydroxybenzoic acidHuman immunodeficiency virus 1--694787 2D-image
3.5e-06-3-(2,5-diethoxyphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
9.2e-06-3-(2,5-diethoxyphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
2.4e-05-3-(2,5-diethoxyphenylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
0.000126-3-(2,5-dimethylphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
6.5e-05-3-(2,5-dimethylphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
0.000196-3-(2,5-dimethylphenylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
5.9e-05-3-(2-chlorophenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
8.9e-05-3-(2-chlorophenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
7e-05-3-(2-chlorophenylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
0.0001-3-(2-ethylphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
2.2e-05-3-(2-ethylphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
0.00026-3-(benzylsulfanyl)-4-hydroxy-6,6-diphenyl-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.0017-3-(benzylsulfanyl)-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
6e-05-3-(benzylsulfanyl)-4-hydroxy-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.000128-3-(benzylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
7.3e-05-3-(benzylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
3.2e-05-3-(benzylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
6.4e-05-3-(o-tolylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
6.1e-05-3-(o-tolylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
0.00024-3-(o-tolylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
0.12-3-benzyl-4-hydroxy-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
9.8e-06-3-[(2-tert-butyl-5-methylphenyl)sulfanyl]-4-hydroxy-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
1.7e-05-3-[(2-tert-butylphenyl)sulfanyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3.6e-06-3-[(2-tert-butylphenyl)sulfanyl]-4-hydroxy-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.00048-3-[(benzylsulfanyl)(phenyl)methyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
8.4e-05-3-[1-(benzylsulfanyl)-2-cyclopropylethyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.00026-3-[1-(benzylsulfanyl)-3-methylbutyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.00015-3-[1-(cyclohexylsulfanyl)-2-cyclopropylethyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
6.9e-05-3-[1-(cyclopentylsulfanyl)-2-cyclopropylethyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
5.8e-05-3-[1-(cyclopentylsulfanyl)-3-methylbutyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.00023-3-[cyclopentyl(cyclopentylsulfanyl)methyl]-4-hydroxy-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.00052-4,7-dihydroxy-3-[4-(2-methoxyphenyl)butyl]-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
0.023-4-acetylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-4-acetylphenoxyacetylHuman immunodeficiency virus 1-IC50: 0.023 mM648152 2D-image
0.019-4-acetylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-4-acetylphenoxyacetylHuman immunodeficiency virus 1-IC50: 0.019 mM648152 2D-image
2-4-Benzyl-1-[2-hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamideHuman immunodeficiency virus 1-IC50: 2.0 mM648128 2D-image
0.08-4-formylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-4-acetylphenoxyacetylHuman immunodeficiency virus 1-IC50: 0.08 mM648152 2D-image
0.068-4-formylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-4-acetylphenoxyacetylHuman immunodeficiency virus 1-IC50: 0.068 mM648152 2D-image
0.018-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
0.0023-4-hydroxy-3-(3-phenoxypropyl)-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
0.11-4-hydroxy-3-(4-phenylbutyl)-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
0.00042-4-hydroxy-3-[(2-methylphenyl)sulfanyl]-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
7.3e-05-4-hydroxy-3-[(2-methylphenyl)sulfanyl]-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.026-4-hydroxy-3-[3-(phenylsulfanyl)propyl]-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
0.00041-4-hydroxy-3-[3-methyl-1-(phenylsulfanyl)butyl]-6-phenyl-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.0017-4-hydroxy-3-[4-(2-methoxyphenyl)butyl]-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
9.6e-05-4-hydroxy-6-(3-methylbutyl)-6-phenyl-3-[(2-phenylethyl)sulfanyl]-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
7e-06-4-hydroxy-6-(3-methylphenyl)-3-[[2-(propan-2-yl)phenyl]sulfanyl]-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.00052-4-hydroxy-6-(4-hydroxyphenyl)-3-[(2-phenylethyl)sulfanyl]-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
8.4e-05-4-hydroxy-6-pentyl-6-phenyl-3-[(2-phenylethyl)sulfanyl]-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.003-4-hydroxy-6-phenyl-3-(phenylsulfanyl)-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.0013-4-hydroxy-6-phenyl-3-[(2-phenylethyl)sulfanyl]-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.0021-4-hydroxy-6-phenyl-3-[(2-phenylethyl)sulfanyl]-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.0051-4-hydroxy-6-phenyl-3-[(2-phenylethyl)sulfanyl]-6-propyl-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.00078-4-hydroxy-6-phenyl-3-[phenyl(phenylsulfanyl)methyl]-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
3.7e-05-4-hydroxy-6-phenyl-3-[[2-(propan-2-yl)phenyl]sulfanyl]-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.00013-4-hydroxy-6-phenyl-6-(2-phenylethyl)-3-(phenylsulfanyl)-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
1.4e-05-4-hydroxy-6-phenyl-6-(2-phenylethyl)-3-[[2-(propan-2-yl)phenyl]sulfanyl]-5,6-dihydro-2H-pyran-2-oneHuman immunodeficiency virus 1--708083-
0.0019-4-hydroxy-7,8-dimethyl-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-oneHuman immunodeficiency virus 1--708083-
1e-07-4-oxo-4H-chromene-2-carboxylic acid (1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amideHuman immunodeficiency virus 1-IC50: 0.1 nM648128 2D-image
0.000159-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenyl-3-(phenylthio)pyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
0.000126-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenyl-3-(phenylthio)pyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
0.000258-5,6-dihydro-4-hydroxy-6-phenyl-3-(phenylthio)-6-((phenylthio)methyl)pyran-2-oneHuman immunodeficiency virus 1-in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication718075-
0.029-5-(3-chlorobenzyl)-1,2-dihydro-3H-pyrazol-3-oneHuman immunodeficiency virus 1--708083-
0.0058-5-tridecylbenzene-1,3-diolHuman immunodeficiency virus 1--694787 2D-image
0.0026-5-[(8Z)-pentadec-8-en-1-yl]benzene-1,3-diolHuman immunodeficiency virus 1--694787 2D-image
5e-06-5-[4-hydroxy-6-oxo-2-phenyl-5-[(2-phenylethyl)sulfanyl]-3,6-dihydro-2H-pyran-2-yl]pentanoic acidHuman immunodeficiency virus 1--708083-
0.19-Ac-HMSFNLHuman immunodeficiency virus 1-IC50: 0.19 mM648129 2D-image
0.44-Ac-QIGMTLNFHuman immunodeficiency virus 1-IC50: 0.44 mM648129 2D-image
1.5-Ac-TLNFHuman immunodeficiency virus 1-IC50: 1.5 mM648129 2D-image
2-Ac-TLNF-NH2Human immunodeficiency virus 1-IC50 is above 2 mM648129 2D-image
0.08-Ac-TVSFNFHuman immunodeficiency virus 1-IC50: 0.08 mM648129 2D-image
9e-05-acetyl-pepstatinHuman immunodeficiency virus 1--694787, 697300, 707180 2D-image
0.87-Arg-Leu-Asn-PheHuman immunodeficiency virus 1-IC50: 0.87 mM648129 2D-image
1.78e-05-ATBIHuman immunodeficiency virus 1-natural ATBI710216-
0.072-ATBIHuman immunodeficiency virus 1-recombinant ATBI710216-
2e-06-benzyl [(5S,8S,9R,10R,11S,14S)-8,11-dibenzyl-9,10-dihydroxy-15-methyl-3,6,13-trioxo-1-phenyl-5-(propan-2-yl)-2-oxa-4,7,12-triazahexadecan-14-yl]carbamateHuman immunodeficiency virus 1--708383-
8e-09-darunavirHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971 2D-image
2.5e-08-darunavirHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971 2D-image
0.0265-dryopteric acid AHuman immunodeficiency virus 1--697300 2D-image
0.41-IGRNLLTQIGCTLNFHuman immunodeficiency virus 1-IC50: 0.41 mM648129 2D-image
1.3e-06-indinavirHuman immunodeficiency virus 1-IC50: 1.3 nM648152 2D-image
3.02e-06-indinavirHuman immunodeficiency virus 1-wild-type699896 2D-image
2.6e-05-indinavirHuman immunodeficiency virus 1-mutant V82A699896 2D-image
0.0015-indinavirHuman immunodeficiency virus 1-mutant V82F/I84V699896 2D-image
6.3e-06-KVS-1Human immunodeficiency virus 1--708877-
3e-06-Kyn-(D-alpha-(2-thienyl)glycine)-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetylHuman immunodeficiency virus 1-IC50: 3 nM648152 2D-image
4e-06-Kyn-Thr-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetylHuman immunodeficiency virus 1-IC50: 4 nM648152 2D-image
3e-06-Kyn-Val-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetylHuman immunodeficiency virus 1-IC50: 3 nM648152 2D-image
4e-06-Kyn-Val-Phe-PSI(S,R,S)[OH]-Phe-Val-KynHuman immunodeficiency virus 1-IC50: 4 nM648152 2D-image
3e-06-Kyn-Val-Phe-PSI(S,S,S)[OH]-Phe-2,6-dimethylphenoxyacetylHuman immunodeficiency virus 1-IC50: 3 nM648152 2D-image
0.67-L-700,417Human immunodeficiency virus 1-IC50: 0.67 mM648125 2D-image
7.8e-06-L-704,486Human immunodeficiency virus 1-IC50: 7.8 nM648128 2D-image
9e-08-lopinavirHuman immunodeficiency virus 1-wild type enzyme, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971 2D-image
9e-07-lopinavirHuman immunodeficiency virus 1-mutant enzyme L10I/L63P/A71V/G73S/I84V/L90M, in 0.1 M sodium acetate, 1 M sodium chloride, 1 mM EDTA, 1 mM dithiothreitol, 2% (v/v) DMSO, and 1 mg/ml bovine serum albumin, at pH 4.7 and 22°C717971 2D-image
0.0389-manassantin AHuman immunodeficiency virus 1--707180-
0.0106-methyl 4-[([6-[([4-[(tert-butoxycarbonyl)amino]thiophen-2-yl]carbonyl)amino]-1,3-benzoxazol-2-yl]carbonyl)amino]thiophene-2-carboxylateHuman immunodeficiency virus 1-L24I/M46I/F53L/L63P/V77I/V82A mutant protein707444-
2.4e-06-morpholine-4-carboxylic acid (1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amideHuman immunodeficiency virus 1-IC50: 2.4 nM648128 2D-image
1.3e-06-N-(1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-isonicotinamideHuman immunodeficiency virus 1-IC50: 1.3 nM648128 2D-image
8e-07-N-(1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-nicotinamideHuman immunodeficiency virus 1-IC50: 0.8 nM648128 2D-image
4e-07-N-[(2R,6S)-6-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-7-hydroxyheptan-2-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717327-
7e-09-N-[(2S,6S)-6-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-7-hydroxyheptan-2-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717327-
1.3e-08-N-[(3S,7S)-7-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-1,8-dihydroxyoctan-3-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717327-
1e-07-N-[(3S,7S)-7-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-8-hydroxy-2-methyloctan-3-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717327-
1.6e-08-N-[(3S,7S)-7-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-8-hydroxyoctan-3-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717327-
1e-07-N-[(4S,8S)-8-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-9-hydroxynonan-4-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717327-
5e-07-N-[(5S)-5-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-6-hydroxyhexyl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717327-
3e-08-N-[(5S)-5-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-6-hydroxyhexyl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamideHuman immunodeficiency virus 1-pH and temperature not specified in the publication717327-
1.9e-06-nelfinavirHuman immunodeficiency virus 1-IC50: 1.9 nM648152 2D-image
1.9e-06-nelfinavirHuman immunodeficiency virus 1--709467 2D-image
2.34e-06-nelfinavirHuman immunodeficiency virus 1-wild-type699896 2D-image
2.87e-06-nelfinavirHuman immunodeficiency virus 1-mutant V82A699896 2D-image
0.00024-nelfinavirHuman immunodeficiency virus 1-mutant V82F/I84V699896 2D-image
0.017-phenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-phenoxyacetylHuman immunodeficiency virus 1-IC50: 0.017 mM648152-
0.005-phenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-phenoxyacetylHuman immunodeficiency virus 1-IC50: 0.005 mM648152-
1.3e-06-pyridin-3-ylmethyl [(5S,8S,9R,10R,11S,14S)-8,11-dibenzyl-9,10-dihydroxy-15-methyl-3,6,13-trioxo-5-(propan-2-yl)-1-(pyridin-3-yl)-2-oxa-4,7,12-triazahexadecan-14-yl]carbamateHuman immunodeficiency virus 1--708383-
4.6e-06-pyridine-2-carboxylic acid (1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amideHuman immunodeficiency virus 1-IC50: 4.6 nM648128 2D-image
0.0121-rac-(3S,4S)-N-benzyl-2-(2,6-dimethyl-phenoxy)-N-4-[[(isobutyl-(toluene-4-sulfonyl)-amino)-methyl]-pyrrolidin-3-ylmethyl]-acetamideHuman immunodeficiency virus 1-IC50 is 0.0121 mM, binding structure analysis, modelling664605 2D-image
0.0033-rac-(3S,4S)-N-[4-([4-amino-benzenesulfonyl-isobutyl-amino]-methyl)-pyrrolidin-3-ylmethyl]-N-benzyl-2-(2,6-dimethyl-phenoxy)-acetamideHuman immunodeficiency virus 1-IC50 is 0.0033 mM, binding structure analysis, modelling664605 2D-image
0.0022-rac-(3S,4S)-N-[4-([benzenesulfonyl-isobutyl-amino]-methyl)-pyrrolidin-3-ylmethyl]-N-benzyl-2-(2,6-dimethyl-phenoxy)-acetamideHuman immunodeficiency virus 1-IC50 is 0.0022 mM, binding structure analysis, modelling664605 2D-image
1.25e-06-ritonavirHuman immunodeficiency virus 1-wild-type699896 2D-image
3e-06-ritonavirHuman immunodeficiency virus 1-IC50: 3 nM648152 2D-image
6.26e-06-ritonavirHuman immunodeficiency virus 1-mutant V82A699896 2D-image
0.00025-ritonavirHuman immunodeficiency virus 1-mutant V82F/I84V699896 2D-image
0.8-RTLNLGLHuman immunodeficiency virus 1-IC50 is above 0.8 mM648129 2D-image
1.2e-07-saquinavirHuman immunodeficiency virus 1-wild-type699896 2D-image
2.8e-07-saquinavirHuman immunodeficiency virus 1-mutant V82A699896 2D-image
4e-07-saquinavirHuman immunodeficiency virus 1--709467 2D-image
1.2e-05-saquinavirHuman immunodeficiency virus 1-mutant V82F/I84V699896 2D-image
0.47-Ser-Leu-Asn-PheHuman immunodeficiency virus 1-IC50: 0.47 mM648129 2D-image
0.28-SFNLHuman immunodeficiency virus 1-IC50: 0.28 mM648129 2D-image
0.31-SFNLEHuman immunodeficiency virus 1-IC50: 0.31 mM648129 2D-image
0.38-Thr-Leu-Asn-LeuHuman immunodeficiency virus 1-IC50: 0.38 mM648129 2D-image
2-Thr-Leu-Asn-Phe-NH2Human immunodeficiency virus 1-IC50 is above 2 mM648129 2D-image
1-Thr-Leu-Asn-TyrHuman immunodeficiency virus 1-IC50 is about 1 mM648129 2D-image
0.45-Thr-Phe-Asn-PheHuman immunodeficiency virus 1-IC50: 0.45 mM648129 2D-image
3e-05-tipranavirHuman immunodeficiency virus 1-IC50 is 30 nM, interacts with residues Asp25 and Asp25', and Ile50 and Ile50'664605 2D-image
0.8-TLNLGFHuman immunodeficiency virus 1