Information on EC 2.8.2.15 - steroid sulfotransferase:
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The lowest common taxonomy group for this enzyme is: Eukaryota

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EC NUMBERCOMMENTARY
2.8.2.15-

RECOMMENDED NAMEGeneOntology No.
steroid sulfotransferaseGO:0050294

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
3'-phosphoadenylyl sulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate
show the reaction diagram		broad specificity; broad specificity resembling EC 2.8.2.2 alcohol sulfotransferase, but also acts on estrone---

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
sulfate group transfer----

PATHWAYKEGG LinkMetaCyc Link
No entries in this field

SYSTEMATIC NAMEIUBMB Comments
3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferaseBroad specificity resembling EC 2.8.2.2 alcohol sulfotransferase, but also acts on estrone.

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
3alpha-hydroxysteroid sulfotransferaseCavia porcellus--645736
ADT sulfotransferaseHomo sapiens--662232
BNST4Brassica napusQ6T261-663165
cholesterol sulfotransferaseHomo sapiens--662582, 675275
cholesterol sulfotransferaseMus musculus--706919
cytosolic sulfotransferaseHomo sapiens, Mus musculus--702138
dehydroepiandrosterone sulfotransferaseHomo sapiens--662232, 674394, 676256, 677218
dehydroepiandrosterone sulfotransferase family 1A member 2Homo sapiens--673350
DHEA sulfotransferaseHomo sapiens--662232
DHEA sulphotransferaseHomo sapiens--645729, 645733
DHEA-STHomo sapiens--645733, 645739, 662232, 673061
ESTHomo sapiens--645731
hEST1Homo sapiens--645738
hydroxysteroid sulfotransferaseSus scrofa--661953, 675477
hydroxysteroid sulfotransferaseHomo sapiens--673061
phenol sulfotransferaseRattus norvegicus--645726
PstMus musculus--645735
ST2A3Homo sapiens--673061
St2b2Mus musculus--706919
steroid alcohol sulfotransferase----
steroid sulfataseHomo sapiens--645740, 645741
steroid-/bile acid-sulfotransferaseHomo sapiens--676007
steroid/bile acid-sulfotransferaseMus musculus--673838
steroid/bile acid-sulfotransferaseHomo sapiens--675998
steroid/sterol sulfotransferaseHomo sapiens--675275
STIIIRattus norvegicus--645722
STSHomo sapiens--645741
sulfotransferase 2A1Homo sapiens--661577
sulfotransferase 2B1Homo sapiens--673295
sulfotransferase 2B1bHomo sapiens--660966, 661253
sulfotransferase IIRattus norvegicus--645726
sulfotransferase IIIRattus norvegicus--645722
SULT 1 isoform 6Danio rerioQ6DHH8-660901
SULT 1E1Homo sapiens--662863
SULT1B1Homo sapiens-isoform702138
SULT1C2Homo sapiens-isoform702138
SULT1D1Mus musculus-isoform702138
Sult2aMus musculus--677268
SULT2A1Homo sapiens--661577, 673061, 673350, 674394, 675998, 676007, 676256, 677143, 677218
SULT2A1Mus musculus--673311, 673838
SULT2A1Sus scrofaQ3S3F7-675477
SULT2A1Mus musculus-isoform702138
SULT2B1Homo sapiens--645739, 673295
SULT2B1bHomo sapiens--660966, 661253, 662582, 675275
testosterone sulfotransferaseCavia porcellus--645736
hydroxysteroid sulfotransferaseMus musculus--673311, 677268
additional informationHomo sapiens-SULT2A1 belongs to the family of phenol sulfotransferases673061
additional informationMus musculus-cf. EC 2.8.2.14, bile salt sulfotransferase 2, SULT2A2673311
additional informationHomo sapiens-cf. EC 2.8.2.2675275
additional informationMus musculus-cf. EC 2.8.2.2677268

CAS REGISTRY NUMBERCOMMENTARY
9032-76-2-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Bos taurusbovine645733--Manually annotated by BRENDA team
Brassica napus-663165Q6T261SwissProtManually annotated by BRENDA team
Brassica napuscv. Westar645737--Manually annotated by BRENDA team
Cavia porcellusenglish shorthair; guinea pig645732--Manually annotated by BRENDA team
Cavia porcellusguinea pig645733, 645736--Manually annotated by BRENDA team
Danio reriorecombinant enzyme660901Q6DHH8SwissProtManually annotated by BRENDA team
Danio reriorecombinant enzyme661469Q7ZUS4SwissProtManually annotated by BRENDA team
Homo sapiens-660966, 661253, 662582, 662863, 673350, 674394, 675275, 675998, 676007, 677218, 702138--Manually annotated by BRENDA team
Homo sapienshuman645723, 645724, 645729, 645731, 645733, 645734, 645738, 645739, 645740, 645741--Manually annotated by BRENDA team
Homo sapienshuman, isoenzyme DHEA-ST645739Q06520GenBankManually annotated by BRENDA team
Homo sapienshuman, isoenzyme SULT2B1a; human, isoenzyme SULT2B1b645739O00204GenBankManually annotated by BRENDA team
Homo sapiensrecombinant enzyme661577, 662232--Manually annotated by BRENDA team
Homo sapiensSULT2A1673061, 676256, 677143--Manually annotated by BRENDA team
Homo sapienstwo isozymes SULT2B1a and SULT2B1b673295--Manually annotated by BRENDA team
Mus musculus-673838, 702138, 706919--Manually annotated by BRENDA team
Mus musculusmouse645735--Manually annotated by BRENDA team
Mus musculuswild-type and farnesoid X receptor-null mice673311--Manually annotated by BRENDA team
Mus musculuswild-type C57BL/6N mice and farnesoid X receptor FXR-null mice677268--Manually annotated by BRENDA team
Rattus norvegicusCDR Fisher, male; rat645722--Manually annotated by BRENDA team
Rattus norvegicusmale and female; rat; Sprague-Dawley645726--Manually annotated by BRENDA team
Rattus norvegicusmale rats; rat; Sprague-Dawley645727, 645728--Manually annotated by BRENDA team
Rattus norvegicusrat645733--Manually annotated by BRENDA team
Rattus norvegicusrat; Wistar, male645730--Manually annotated by BRENDA team
Sus scrofapig645725--Manually annotated by BRENDA team
Sus scrofaSULT2A1; mature Yorkshire boars, SULT2A1675477Q3S3F7SwissProtManually annotated by BRENDA team
Sus scrofayorkshire boar661953--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
physiological functionMus musculus-expression of St2b2 is a trigger of epidermal cell differentiation by controlling cholesterol sulfate level in the cells706919

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylyl sulfate + 1-naphtholadenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram		Mus musculus, Homo sapiens--702138--?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acidadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Mus musculus, Homo sapiens--702138--?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytiboloneadenosine 3',5'-bisphosphate + 3alpha-hydroxytibolone 3-O-sulfate
show the reaction diagram		Homo sapiens-sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis677143--?
3'-phosphoadenylyl sulfate + 3beta-hydroxytiboloneadenosine 3',5'-bisphosphate + 3beta-hydroxytibolone 3-O-sulfate
show the reaction diagram		Homo sapiens-sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis677143--?
3'-phosphoadenylyl sulfate + 4'-hydroxy-2,3',4,5'-tetrachlorobiphenyladenosine 3',5'-bisphosphate + 4'-hydroxy-2,3',4,5'-tetrachlorobiphenyl 4'-O-sulfate
show the reaction diagram		Homo sapiens-i.e. 4'-OH PCB 68, substrate of SULT1A2673061--?
3'-phosphoadenylyl sulfate + 4-hydroxy-2',3,5-trichlorobiphenyladenosine 3',5'-bisphosphate + 2',3,5-trichlorobiphenyl-4-yl hydrogen sulfate
show the reaction diagram		Homo sapiens-i.e. 4-OH PCB 34, substrate of SULT1A2673061--?
3'-phosphoadenylyl sulfate + 4-nitrophenoladenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram		Mus musculus, Homo sapiens--702138--?
3'-phosphoadenylyl sulfate + 5alpha,6alpha-epoxycholesteroladenosine 3',5'-bisphosphate + 5alpha,6alpha-epoxycholesteryl sulfate
show the reaction diagram		Homo sapiens--675275--?
3'-phosphoadenylyl sulfate + 5beta,6beta-epoxycholesteroladenosine 3',5'-bisphosphate + 5beta,6beta-epoxycholesteryl sulfate
show the reaction diagram		Homo sapiens--675275--?
3'-phosphoadenylyl sulfate + 7-oxo-cholesteroladenosine 3',5'-bisphosphate + 7-oxo-cholesteryl sulfate
show the reaction diagram		Homo sapiens--675275--?
3'-phosphoadenylyl sulfate + 7alpha-hydroxycholesteroladenosine 3',5'-bisphosphate + 7alpha-hydroxycholesteryl sulfate
show the reaction diagram		Homo sapiens--675275--?
3'-phosphoadenylyl sulfate + 7beta-hydroxycholesteroladenosine 3',5'-bisphosphate + 7beta-hydroxycholesteryl sulfate
show the reaction diagram		Homo sapiens--675275--?
3'-phosphoadenylyl sulfate + beta-estradioladenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram		Mus musculus, Homo sapiens--702138--?
3'-phosphoadenylyl sulfate + cholesteroladenosine 3',5'-bisphosphate + cholesteryl 3-sulfate
show the reaction diagram		Mus musculus--706919--?
3'-phosphoadenylyl sulfate + cholesteroladenosine 3',5'-bisphosphate + cholesteryl sulfate
show the reaction diagram		Homo sapiens--675275--?
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Mus musculus--677268--?
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
show the reaction diagram		Mus musculus--673311--?
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
show the reaction diagram		Homo sapiens--673295, 674394, 676256, 677143--?
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
show the reaction diagram		Sus scrofaQ3S3F7-675477--?
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
show the reaction diagram		Homo sapiens-variant haplotypes in tissues possessing alterations in activity or stability may alter the plasma levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate thereby altering the conversion of dehydroepiandrosterone in tissues, overview676256--?
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
show the reaction diagram		Homo sapiens-i.e. DHEA, substrate of SULT1A2673061--?
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone O-sulfate
show the reaction diagram		Homo sapiens--673061--?
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Mus musculus, Homo sapiens--702138--?
3'-phosphoadenylyl sulfate + despiramineadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Mus musculus, Homo sapiens--702138--?
3'-phosphoadenylyl sulfate + L-triiodothyronineadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Mus musculus, Homo sapiens--702138--?
3'-phosphoadenylyl sulfate + L-triiodothyronineadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ7ZUS4-661469---
3'-phosphoadenylyl sulfate + xanthurenic acidadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Mus musculus, Homo sapiens--702138--?
3'-phosphoadenylylsulfate + (22S,23S)-28-homobrassinolideadenosine 3',5'-bisphosphate + (22S,23S)-28-homobrassinolide sulfate
show the reaction diagram		Brassica napus--645737--r
3'-phosphoadenylylsulfate + (22S,23S)-28-homocastasteroneadenosine 3',5'-bisphosphate + (22S,23S)-28-homocastasterone sulfate
show the reaction diagram		Brassica napus--645737--r
3'-phosphoadenylylsulfate + 11-deoxycorticosteroneadenosine 3',5'-bisphosphate + 11-deoxycorticosterone sulfate
show the reaction diagram		Homo sapiens-21-hydroxypregn-4-en-3,20-dione645724pregn-4-en-3-one 21-sulfate645724r
3'-phosphoadenylylsulfate + 16-hydroxy-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Homo sapiens--645738--r
3'-phosphoadenylylsulfate + 17alpha-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Homo sapiens-estra-1,3,5(10)-triene-3,17alpha-diol645724--r
3'-phosphoadenylylsulfate + 17alpha-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Rattus norvegicus-estra-1,3,5(10)-triene-3,17alpha-diol645727--r
3'-phosphoadenylylsulfate + 17alpha-ethynylestradioladenosine 3',5'-bisphosphate + 17alpha-ethynylestradiol 3-sulfate
show the reaction diagram		Homo sapiens-celecoxib switches sulfation from the 3-O-position to the 17beta-O-position661577--?
3'-phosphoadenylylsulfate + 17beta-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Cavia porcellus--645733--r
3'-phosphoadenylylsulfate + 17beta-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Mus musculus--645735--r
3'-phosphoadenylylsulfate + 17beta-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Homo sapiens--645733, 645734--r
3'-phosphoadenylylsulfate + 17beta-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Rattus norvegicus--645722, 645730, 645733--r
3'-phosphoadenylylsulfate + 17beta-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Brassica napus--645737--r
3'-phosphoadenylylsulfate + 17beta-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Cavia porcellus-3alphaHST isoform645736--r
3'-phosphoadenylylsulfate + 17beta-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Cavia porcellus-chorion enzyme catalyzes sulfation of estradiol at about double the velocity of estrone645732--r
3'-phosphoadenylylsulfate + 17beta-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Homo sapiens-estra-1,3,5(10)-triene-3,17alpha-diol645723, 645724, 645729--r
3'-phosphoadenylylsulfate + 17beta-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Rattus norvegicus-estra-1,3,5(10)-triene-3,17alpha-diol645727, 645728--r
3'-phosphoadenylylsulfate + 17beta-estradiol 3-methyl etheradenosine 3',5'-bisphosphate + ?
show the reaction diagram		Brassica napus--645737--r
3'-phosphoadenylylsulfate + 17beta-estradiol adenosine3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram		Danio rerioQ7ZUS4-661469--?
3'-phosphoadenylylsulfate + 17beta-estradiol adenosine3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + 2-hydroxy-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Homo sapiens--645738--r
3'-phosphoadenylylsulfate + 2-naphtholadenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram		Rattus norvegicus--645726, 645730--r
3'-phosphoadenylylsulfate + 24-epibrassinolideadenosine 3',5'-bisphosphate + 24-epibrassinolide sulfate
show the reaction diagram		Brassica napus-sulfonation leads to the loss of biological activity645737--r
3'-phosphoadenylylsulfate + 24-epicastasteroneadenosine 3',5'-bisphosphate + 24-epicastasterone sulfate
show the reaction diagram		Brassica napus-highest affinity645737--r
3'-phosphoadenylylsulfate + 24-epicastasteroneadenosine 3',5'-bisphosphate + 24-epicastasterone 3-sulfate
show the reaction diagram		Brassica napusQ6T261-663165--?
3'-phosphoadenylylsulfate + 24-epiteasteroneadenosine 3',5'-bisphosphate + 24-epiteasterone sulfate
show the reaction diagram		Brassica napus--645737--r
3'-phosphoadenylylsulfate + 24-epiteasteroneadenosine 3',5'-bisphosphate + 24-epiteasterone 3-sulfate
show the reaction diagram		Brassica napusQ6T261-663165--?
3'-phosphoadenylylsulfate + 3,3',5-triidothyronine3',5'-bisphosphate + 3,3',5-triiodothyronine 4'-sulfate
show the reaction diagram		Danio rerioQ7ZUS4-661469--?
3'-phosphoadenylylsulfate + 3alpha-hydroxy-5alpha-androstan-17-oneadenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
show the reaction diagram		Cavia porcellus, Homo sapiens--645733-645733r
3'-phosphoadenylylsulfate + 3alpha-hydroxy-5alpha-androstan-17-oneadenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
show the reaction diagram		Homo sapiens-androsterone645723androsterone sulfate645723r
3'-phosphoadenylylsulfate + 3alpha-hydroxy-5alpha-androstan-17-oneadenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
show the reaction diagram		Homo sapiens-androsterone645724androsterone sulfate645724r
3'-phosphoadenylylsulfate + 3alpha-hydroxy-5alpha-androstan-17-oneadenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
show the reaction diagram		Homo sapiens-androsterone645729androsterone sulfate645729r
3'-phosphoadenylylsulfate + 3alpha-hydroxy-5alpha-androstan-17-oneadenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
show the reaction diagram		Cavia porcellus-3alphaHST isoform645736-645736r
3'-phosphoadenylylsulfate + 3beta-hydroxy-5alpha-androstan-17-oneadenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
show the reaction diagram		Homo sapiensO00204, Q06520SULT2B1 isoform645739-645739r
3'-phosphoadenylylsulfate + 3beta-hydroxy-5alpha-androstan-17-oneadenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
show the reaction diagram		Homo sapiens-epiandrosterone645723-645723r
3'-phosphoadenylylsulfate + 3beta-hydroxy-5alpha-androstan-17-oneadenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
show the reaction diagram		Homo sapiens-epiandrosterone645724-645724r
3'-phosphoadenylylsulfate + 3beta-hydroxy-5alpha-androstan-17-oneadenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
show the reaction diagram		Homo sapiens-epiandrosterone645729-645729r
3'-phosphoadenylylsulfate + 4-hydroxy-estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Homo sapiens--645738--r
3'-phosphoadenylylsulfate + 5alpha-androst-16-en-3beta-oladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Sus scrofa--645725--r
3'-phosphoadenylylsulfate + 6-deoxo-24-epicastasteroneadenosine 3',5'-bisphosphate + 6-deoxo-24-epicastasterone sulfate
show the reaction diagram		Brassica napus--645737--r
3'-phosphoadenylylsulfate + allopregnenoloneadenosine 3',5'-bisphosphate + allopregnenolone sulfate
show the reaction diagram		Cavia porcellus--645733---
3'-phosphoadenylylsulfate + allopregnenoloneadenosine 3',5'-bisphosphate + allopregnenolone sulfate
show the reaction diagram		Cavia porcellus-3alphaHST isoform645736-645736r
3'-phosphoadenylylsulfate + androst-5-ene-3beta,17beta-dioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Homo sapiens--645724, 645729--r
3'-phosphoadenylylsulfate + androst-5-ene-3beta17alpha-dioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Homo sapiens--645723, 645724--r
3'-phosphoadenylylsulfate + androstenedioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Homo sapiensO00204, Q06520SULT2B1 isoform645739--r
3'-phosphoadenylylsulfate + androstenedioladenosine 3',5'-bisphosphate + 17beta-hydroxy-androst-5-en-3-sulfate
show the reaction diagram		Brassica napusQ6T261-663165--?
3'-phosphoadenylylsulfate + androsteroneadenosine 3',5'-bisphosphate + 5alpha-androstane-17-one 3-sulfate
show the reaction diagram		Homo sapiens-enzyme is an androsterone sulfotransferase as well as a dehydroepiandrosterone sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver662232--?
3'-phosphoadenylylsulfate + beta-naphthol3',5'-bisphosphate + 2-naphthylsulfate
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + butylated hydroxy anisole3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + caffeic acid3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + catechin3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + chlorogenic acid3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + cholesteroladenosine 3',5'-bisphosphate + cholesterol sulfate
show the reaction diagram		Homo sapiens-sulfurylated at low rate645723--r
3'-phosphoadenylylsulfate + cholesteroladenosine 3',5'-bisphosphate + cholesterol 3-sulfate
show the reaction diagram		Homo sapiens-SULT2B1b, concentration-dependent induction by Ca2+, SULT2B1b662582--?
3'-phosphoadenylylsulfate + cortisoladenosine 3',5'-bisphosphate + cortisol sulfate
show the reaction diagram		Rattus norvegicus--645722--r
3'-phosphoadenylylsulfate + daidzein3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Cavia porcellus--645733, 645736--r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Mus musculus--645735-645735r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Homo sapiens--645733-645733r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Rattus norvegicus--645722-645722r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Rattus norvegicus--645730-645730r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Rattus norvegicus--645733-645733r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Homo sapiensO00204, Q06520SULT2B1 isoform645739-645739r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Cavia porcellus-3betaHST isoform645736--r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Homo sapiens-3beta-hydroxyandrost-5-en-17-one645724-645724r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Homo sapiensO00204, Q06520isoform SULT2B1 is capable of regulating the activity of adrenal androgens via their inactivation by sulfation645739-645739r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Rattus norvegicus-major pathway in the metabolism of steroid hormones645730-645730r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Homo sapiens-conversion of steroids to their inactive sulfated forms, plays a major role in the control of estrogen levels in target tissues645733-645733r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Rattus norvegicus-enzymatic sulfation of steroids645722-645722r
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Homo sapiens-sulfation is an important pathway for biotransformation and inactivation of drugs, xenobiotics, monoamine and catecholamine neurotransmitters and steroid hormones645731-645731-
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Brassica napusQ6T261-663165--?
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
show the reaction diagram		Homo sapiens-enzyme is an androsterone sulfotransferase as well as a dehydroepiandrosterone sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver662232--?
3'-phosphoadenylylsulfate + diethylstilbestroladenosine 3',5'-bisphosphate + diethylstilbestrol sulfate
show the reaction diagram		Mus musculus-synthetic estrogen645735-645735r
3'-phosphoadenylylsulfate + epigallocatechin gallate3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + epitestosteroneadenosine 3',5'-bisphosphate + epitestosterone sulfate
show the reaction diagram		Homo sapiens-17alpha-hydroxyandrost-4-en-3-one645724androst-4-en-3-one 17-sulfate645724r
3'-phosphoadenylylsulfate + estradioladenosine 3',5'-bisphosphate + ?
show the reaction diagram		Homo sapiens--662863--?
3'-phosphoadenylylsulfate + estrioladenosine 3',5'-bisphosphate + estriol sulfate
show the reaction diagram		Homo sapiens--645734-645734r
3'-phosphoadenylylsulfate + estrioladenosine 3',5'-bisphosphate + estriol sulfate
show the reaction diagram		Rattus norvegicus--645730-645730r
3'-phosphoadenylylsulfate + estroneadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ7ZUS4-661469--?
3'-phosphoadenylylsulfate + estroneadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + estroneadenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram		Cavia porcellus--645732-645732r
3'-phosphoadenylylsulfate + estroneadenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram		Homo sapiens--645731-645731r
3'-phosphoadenylylsulfate + estroneadenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram		Homo sapiens--645734-645734r
3'-phosphoadenylylsulfate + estroneadenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram		Rattus norvegicus--645730-645730r
3'-phosphoadenylylsulfate + estroneadenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram		Homo sapiens--645724estra-1,3,5(10)-trien-17-one 3-sulfate645724r
3'-phosphoadenylylsulfate + estroneadenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram		Homo sapiens--645729estra-1,3,5(10)-trien-17-one 3-sulfate645729r
3'-phosphoadenylylsulfate + etiocholanoneadenosine 3',5'-bisphosphate + etiocholanone sulfate
show the reaction diagram		Homo sapiens-3alpha-hydroxy-5beta-androstan-17-one6457235beta-androstan-17-one 3-sulfate645723r
3'-phosphoadenylylsulfate + etiocholanoneadenosine 3',5'-bisphosphate + etiocholanone sulfate
show the reaction diagram		Homo sapiens-3alpha-hydroxy-5beta-androstan-17-one6457245beta-androstan-17-one 3-sulfate645724r
3'-phosphoadenylylsulfate + etiocholanoneadenosine 3',5'-bisphosphate + etiocholanone sulfate
show the reaction diagram		Homo sapiens-3alpha-hydroxy-5beta-androstan-17-one6457295beta-androstan-17-one 3-sulfate645729r
3'-phosphoadenylylsulfate + genisteinadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Homo sapiensO00204, Q06520-645739--r
3'-phosphoadenylylsulfate + genisteinadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + glycolithocholateadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Rattus norvegicus--645726--r
3'-phosphoadenylylsulfate + kaempferol3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + myricetin3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + n-propyl gallate3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + p-nitrophenol3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + pregnenoloneadenosine 3',5'-bisphosphate + pregnenolone sulfate
show the reaction diagram		Cavia porcellus--645733--r
3'-phosphoadenylylsulfate + pregnenoloneadenosine 3',5'-bisphosphate + pregnenolone sulfate
show the reaction diagram		Homo sapiens--645733-645733r
3'-phosphoadenylylsulfate + pregnenoloneadenosine 3',5'-bisphosphate + pregnenolone sulfate
show the reaction diagram		Rattus norvegicus--645730-645730r
3'-phosphoadenylylsulfate + pregnenoloneadenosine 3',5'-bisphosphate + pregnenolone sulfate
show the reaction diagram		Rattus norvegicus--645733-645733r
3'-phosphoadenylylsulfate + pregnenoloneadenosine 3',5'-bisphosphate + pregnenolone sulfate
show the reaction diagram		Homo sapiens--645723pregn-5-en-20-one 3-sulfate645723r
3'-phosphoadenylylsulfate + pregnenoloneadenosine 3',5'-bisphosphate + pregnenolone sulfate
show the reaction diagram		Homo sapiens--645729pregn-5-en-20-one 3-sulfate645729r
3'-phosphoadenylylsulfate + pregnenoloneadenosine 3',5'-bisphosphate + pregnenolone sulfate
show the reaction diagram		Sus scrofa--645725pregn-5-en-20-one 3-sulfate645725r
3'-phosphoadenylylsulfate + pregnenoloneadenosine 3',5'-bisphosphate + pregnenolone sulfate
show the reaction diagram		Homo sapiensO00204, Q06520SULT2B1 isoform645739-645739r
3'-phosphoadenylylsulfate + pregnenoloneadenosine 3',5'-bisphosphate + pregnenolone sulfate
show the reaction diagram		Cavia porcellus-3betaHST isoform645736--r
3'-phosphoadenylylsulfate + pregnenoloneadenosine 3',5'-bisphosphate + pregnenolone sulfate
show the reaction diagram		Homo sapiens-3beta-hydroxypregn-5-en-20-one645724pregn-5-en-20-one 3-sulfate645724r
3'-phosphoadenylylsulfate + pregnenoloneadenosine 3',5'-bisphosphate + pregn-5-en-20-one 3-sulfate
show the reaction diagram		Brassica napusQ6T261-663165--?
3'-phosphoadenylylsulfate + quercetin3',5'-bisphosphate + ?
show the reaction diagram		Danio rerioQ6DHH8-660901--?
3'-phosphoadenylylsulfate + taurolithocholateadenosine 3',5'-bisphosphate + taurolithocholate sulfate
show the reaction diagram		Rattus norvegicus--645728--r
3'-phosphoadenylylsulfate + testosteroneadenosine 3',5'-bisphosphate + testosterone sulfate
show the reaction diagram		Rattus norvegicus--645722-645722r
3'-phosphoadenylylsulfate + testosteroneadenosine 3',5'-bisphosphate + testosterone sulfate
show the reaction diagram		Rattus norvegicus--645730-645730r
3'-phosphoadenylylsulfate + testosteroneadenosine 3',5'-bisphosphate + testosterone sulfate
show the reaction diagram		Cavia porcellus-3alphaHST isoform645736only 3alpha-hydroxysteroid isoform, 3beta-hydroxysteroid isoform exhibits no TST activity645736r
3'-phosphoadenylylsulfate + testosteroneadenosine 3',5'-bisphosphate + testosterone sulfate
show the reaction diagram		Homo sapiens-17beta-hydroxyandrost-4-en-3-one645723androst-4-en-3-one 17-sulfate645723r
3'-phosphoadenylylsulfate + testosteroneadenosine 3',5'-bisphosphate + testosterone sulfate
show the reaction diagram		Homo sapiens-17beta-hydroxyandrost-4-en-3-one645724androst-4-en-3-one 17-sulfate645724r
3'-phosphoadenylylsulfate + testosteroneadenosine 3',5'-bisphosphate + testosterone sulfate
show the reaction diagram		Homo sapiens-17beta-hydroxyandrost-4-en-3-one645729androst-4-en-3-one 17-sulfate645729r
3'-phosphoadenylylsulfate + thyroxineadenosyl 3',5'-bisphosphate + O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodotyrosine
show the reaction diagram		Danio rerioQ7ZUS4-661469--?
additional information?-Rattus norvegicus-also sulfates estrogens and glucocorticoids to lesser extents645726---
additional information?-Rattus norvegicus-oestrone 3-sulfate is no substrate, no taurolithocholate sulfotransferase activity645727---
additional information?-Homo sapiens-very limited sulfotransferase activity against dehydroepiandrosterone, testosterone and pregnenolone645734---
additional information?-Rattus norvegicus-not active towards androgens645730---
additional information?-Brassica napus-little or no activity with brassinolide, (22S,23R)-28-homobrassinolide, and 22-deoxy-24-epiteasterone645737---
additional information?-Homo sapiensO00204, Q06520isoform SULT2B1, no activity detected towards testosterone, dihydrotestosterone, dexamethasone, beta-estradiol, cholesterol, cortisol, androsterone, or p-nitrophenol, no antibody reaction with EST, P-PST-1, M-PST, DHEA-ST, or ST1B2 during immunoblot analysis645739---
additional information?-Homo sapiens-little or no activity with pregn-4-ene-11beta,21-diol-3,20-dione/cortisol and oestra-1,3,5(10)-triene-3,17beta-diol-3 methyl ether/17beta-oestradiol-3 methyl ether645724---
additional information?-Homo sapiens-specific for endogenous and xenobiotic estrogens645731---
additional information?-Rattus norvegicus-activity for bile acids and phenolic steroids645728---
additional information?-Homo sapiens-no activity towards p-nitrophenol or dopamine645729---
additional information?-Cavia porcellus-estrone is no substrate645736---
additional information?-Brassica napusQ6T261BNST4 is an ethanol-inducible steroid sulfotransferase663165---
additional information?-Homo sapiens-presence of SULT2b1b suggests a role in the regulation of local steroid hormone synthesis and metabolism661253---
additional information?-Sus scrofa-the enzyme is responsible for the sulfoconjugation of the 16-androstene steroids. Hydroxysteroid sulfotransferase may play a significant role in determining the levels of sulfated 16-androstene steroids present in plasma. Sulfoconjugation may serve to regulate the quantity of unconjugated 5alpha-androstenone present in the circulation and thus available for accumulation. Animals with a decreased ability to sulfoconjugate 5alpha-androstenone would have a subsequent increase in the levels of unconjugated 5alpha-androstenone in circulation, allowing for the accumulation of high levels in fat and thereby potentially leading to the development of boar taint661953---
additional information?-Homo sapiens-sulfotransferase 2B1b is selective for the sulfation of 3beta-hydroxysteroids such as dehydroepiandrosterone, pregnenolone and cholesterol661253---
additional information?-Homo sapiens-the SULT2B1 isoforms are highly selective for the sulfation of 3-hydroxysteroids660966---
additional information?-Homo sapiens-hydroxylated polychlorinated biphenyls may compete with other xenobiotic substrates as well as endogenous substrates for SULT2A1673061---
additional information?-Mus musculus-Sult2a is involved in 3alpha-sulfation of bile acids, e.g. of litocholic acid, required for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity, overview677268---
additional information?-Mus musculus-Sult2A1 converts bile acids, steroids and a number of drugs to the corresponding sulfated metabolites, which are readily eliminated from the body due to increased water solubility, deviant expression of steroid- and xenobiotic-metabolizing enzymes due to metabolic stress causes severe health problems including accelerated aging, and increased expression of these enzymes is associated with extended longevity, overview, xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR regulating steroid and xenobiotic metabolism by inducing the phase I cytochrome P450 monooxygenases, phase II conjugating transferases, and the phase III transporters, are involved in enzyme regulation, overview673838---
additional information?-Sus scrofaQ3S3F7SULT2A1 is a key enzyme in the testicular and hepatic metabolism of 5alpha-androstenone, which is a major component of the off-odor and off-flavor in pork known as boar taint, role of testicular and hepatic SULT2A1 activity on plasma 5alpha-androstenone sulfate levels, the accumulation of 5alpha-androstenone in adipose tissue, regulatory control of SULT2A1, SULT2A1 activity is negatively correlated with 5alpha-androstenone concentrations in fat, identification of nuclear receptors involved in regulating SULT2A1, overview675477---
additional information?-Homo sapiens-SULT2A1 is a liver- and intestine-specific sulfo-conjugating enzyme that converts the alcoholic OH of neutral steroids, bile acids, and drugs to water-soluble sulfated metabolites, regulation, overview675998---
additional information?-Homo sapiens-SULT2A1 plays a very important role in formation of steroid sulfate esters, and sulfates both 3alpha- and 3beta-hydroxysteroids, estrogens, testosterone, and aliphatic hydroxyl-containing drugs and xenobiotics676256---
additional information?-Homo sapiens-SULT2A1 plays a very important role in sulfating endogenous hydroxysteroids and exogenousxenobiotics674394---
additional information?-Mus musculus-the enzyme catalyzes bile acid sulfation and plays an essential role in protection against lithocholic acid-induced liver toxicity mediated by the farnesoid X receptor FXR, overview673311---
additional information?-Homo sapiens-the enzyme promotes phase II metabolism through its sulfonating action on certain endobiotics, including steroids and bile acids, and on diverse xenobiotics, including therapeutics drugs, regulation of enzyme expression involving HNF4alpha, overview676007---
additional information?-Homo sapiens-the nuclear receptors constitutive androstane receptor CAR and retinoid X receptor alpha RXRalpha are involved in regulation of SULT2A1 enzyme expression, regulation mechanism, overview677218---
additional information?-Homo sapiens-SULT2B1b sulfates oxosterols, overview675275---

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
3'-phosphoadenylyl sulfate + 1-naphtholadenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram		Mus musculus, Homo sapiens--702138--
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acidadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Mus musculus, Homo sapiens--702138--
3'-phosphoadenylyl sulfate + 3alpha-hydroxytiboloneadenosine 3',5'-bisphosphate + 3alpha-hydroxytibolone 3-O-sulfate
show the reaction diagram		Homo sapiens-sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis677143--
3'-phosphoadenylyl sulfate + 3beta-hydroxytiboloneadenosine 3',5'-bisphosphate + 3beta-hydroxytibolone 3-O-sulfate
show the reaction diagram		Homo sapiens-sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis677143--
3'-phosphoadenylyl sulfate + 4-nitrophenoladenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram		Mus musculus, Homo sapiens--702138--
3'-phosphoadenylyl sulfate + beta-estradioladenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram		Mus musculus, Homo sapiens--702138--
3'-phosphoadenylyl sulfate + cholesteroladenosine 3',5'-bisphosphate + cholesteryl 3-sulfate
show the reaction diagram		Mus musculus--706919--
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Mus musculus--677268--
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
show the reaction diagram		Mus musculus--673311--
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
show the reaction diagram		Homo sapiens--673295, 674394, 677143--
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
show the reaction diagram		Sus scrofaQ3S3F7-675477--
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
show the reaction diagram		Homo sapiens-variant haplotypes in tissues possessing alterations in activity or stability may alter the plasma levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate thereby altering the conversion of dehydroepiandrosterone in tissues, overview676256--
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone O-sulfate
show the reaction diagram		Homo sapiens--673061--
3'-phosphoadenylyl sulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Mus musculus, Homo sapiens--702138--
3'-phosphoadenylyl sulfate + despiramineadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Mus musculus, Homo sapiens--702138--
3'-phosphoadenylyl sulfate + L-triiodothyronineadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Mus musculus, Homo sapiens--702138--
3'-phosphoadenylyl sulfate + xanthurenic acidadenosine 3',5'-bisphosphate + ?
show the reaction diagram		Mus musculus, Homo sapiens--702138--
3'-phosphoadenylylsulfate + androsteroneadenosine 3',5'-bisphosphate + 5alpha-androstane-17-one 3-sulfate
show the reaction diagram		Homo sapiens-enzyme is an androsterone sulfotransferase as well as a dehydroepiandrosterone sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver662232--
3'-phosphoadenylylsulfate + cholesteroladenosine 3',5'-bisphosphate + cholesterol 3-sulfate
show the reaction diagram		Homo sapiens-SULT2B1b, concentration-dependent induction by Ca2+662582--
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Cavia porcellus--645733, 645736--
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Mus musculus--645735-645735
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Rattus norvegicus--645733-645733
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Homo sapiens-3beta-hydroxyandrost-5-en-17-one645724-645724
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Homo sapiensO00204, Q06520isoform SULT2B1 is capable of regulating the activity of adrenal androgens via their inactivation by sulfation645739-645739
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Rattus norvegicus-major pathway in the metabolism of steroid hormones645730-645730
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Homo sapiens-conversion of steroids to their inactive sulfated forms, plays a major role in the control of estrogen levels in target tissues645733-645733
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Rattus norvegicus-enzymatic sulfation of steroids645722-645722
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram		Homo sapiens-sulfation is an important pathway for biotransformation and inactivation of drugs, xenobiotics, monoamine and catecholamine neurotransmitters and steroid hormones645731-645731
3'-phosphoadenylylsulfate + dehydroepiandrosteroneadenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
show the reaction diagram		Homo sapiens-enzyme is an androsterone sulfotransferase as well as a dehydroepiandrosterone sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver662232--
additional information?-Brassica napusQ6T261BNST4 is an ethanol-inducible steroid sulfotransferase663165--
additional information?-Homo sapiens-presence of SULT2b1b suggests a role in the regulation of local steroid hormone synthesis and metabolism661253--
additional information?-Sus scrofa-the enzyme is responsible for the sulfoconjugation of the 16-androstene steroids. Hydroxysteroid sulfotransferase may play a significant role in determining the levels of sulfated 16-androstene steroids present in plasma. Sulfoconjugation may serve to regulate the quantity of unconjugated 5alpha-androstenone present in the circulation and thus available for accumulation. Animals with a decreased ability to sulfoconjugate 5alpha-androstenone would have a subsequent increase in the levels of unconjugated 5alpha-androstenone in circulation, allowing for the accumulation of high levels in fat and thereby potentially leading to the development of boar taint661953--
additional information?-Homo sapiens-hydroxylated polychlorinated biphenyls may compete with other xenobiotic substrates as well as endogenous substrates for SULT2A1673061--
additional information?-Mus musculus-Sult2a is involved in 3alpha-sulfation of bile acids, e.g. of litocholic acid, required for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity, overview677268--
additional information?-Mus musculus-Sult2A1 converts bile acids, steroids and a number of drugs to the corresponding sulfated metabolites, which are readily eliminated from the body due to increased water solubility, deviant expression of steroid- and xenobiotic-metabolizing enzymes due to metabolic stress causes severe health problems including accelerated aging, and increased expression of these enzymes is associated with extended longevity, overview, xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR regulating steroid and xenobiotic metabolism by inducing the phase I cytochrome P450 monooxygenases, phase II conjugating transferases, and the phase III transporters, are involved in enzyme regulation, overview673838--
additional information?-Sus scrofaQ3S3F7SULT2A1 is a key enzyme in the testicular and hepatic metabolism of 5alpha-androstenone, which is a major component of the off-odor and off-flavor in pork known as boar taint, role of testicular and hepatic SULT2A1 activity on plasma 5alpha-androstenone sulfate levels, the accumulation of 5alpha-androstenone in adipose tissue, regulatory control of SULT2A1, SULT2A1 activity is negatively correlated with 5alpha-androstenone concentrations in fat, identification of nuclear receptors involved in regulating SULT2A1, overview675477--
additional information?-Homo sapiens-SULT2A1 is a liver- and intestine-specific sulfo-conjugating enzyme that converts the alcoholic OH of neutral steroids, bile acids, and drugs to water-soluble sulfated metabolites, regulation, overview675998--
additional information?-Homo sapiens-SULT2A1 plays a very important role in formation of steroid sulfate esters, and sulfates both 3alpha- and 3beta-hydroxysteroids, estrogens, testosterone, and aliphatic hydroxyl-containing drugs and xenobiotics676256--
additional information?-Homo sapiens-SULT2A1 plays a very important role in sulfating endogenous hydroxysteroids and exogenousxenobiotics674394--
additional information?-Mus musculus-the enzyme catalyzes bile acid sulfation and plays an essential role in protection against lithocholic acid-induced liver toxicity mediated by the farnesoid X receptor FXR, overview673311--
additional information?-Homo sapiens-the enzyme promotes phase II metabolism through its sulfonating action on certain endobiotics, including steroids and bile acids, and on diverse xenobiotics, including therapeutics drugs, regulation of enzyme expression involving HNF4alpha, overview676007--
additional information?-Homo sapiens-the nuclear receptors constitutive androstane receptor CAR and retinoid X receptor alpha RXRalpha are involved in regulation of SULT2A1 enzyme expression, regulation mechanism, overview677218--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
No entries in this field

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
Ba2+Rattus norvegicus-markedly activated by 5 mM divalent cations645722
Ca2+Rattus norvegicus-markedly activated by 5 mM divalent cations645722
Co2+Rattus norvegicus-markedly activated by 5 mM divalent cations645722
Cr2+Rattus norvegicus-markedly activated by 5 mM divalent cations645722
Mg2+Rattus norvegicus-markedly activated by 5 mM divalent cations645722
Mg2+Homo sapiens--673295
Mg2+Homo sapiens-activates677143
Mn2+Rattus norvegicus-most effective, markedly activated by 5 mM divalent cations645722
NaClHomo sapiens-activates677143
Ni2+Rattus norvegicus-markedly activated by 5 mM divalent cations645722

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
2,3-dichlorophenolHomo sapiens-IC50: 0.0007 mM, vs. 10 nM estradiol662863 2D-image
2,4-DichlorophenolHomo sapiens-IC50: 0.0007 mM, vs. 10 nM estradiol662863 2D-image
2,5-dichlorophenolHomo sapiens-IC50: 0.0022 mM, vs. 10 nM estradiol662863 2D-image
2,6-Dichloro-4-nitrophenolHomo sapiens-non-specific SULT inhibitor702138 2D-image
2,6-dichlorophenolHomo sapiens-IC50: 0.0016 mM, vs. 10 nM estradiol662863 2D-image
2-chlorophenolHomo sapiens-IC50: 0.02 mM, vs. 10 nM estradiol662863 2D-image
2-phenylphenolHomo sapiens-IC50: 0.0052 mM, vs. 10 nM estradiol662863 2D-image
24-epicathasteroneBrassica napus-substrate inhibition above 0.005 mM645737-
24-epiteasteroneBrassica napus-substrate inhibition above 0.005 mM645737 2D-image
3,4-dichlorophenolHomo sapiens-IC50: 0.013 mM, vs. 10 nM estradiol662863 2D-image
3,5-dichlorophenolHomo sapiens-IC50: 0.017 mM, vs. 10 nM estradiol662863 2D-image
3-chlorophenolHomo sapiens-IC50: 0.13 mM, vs. 10 nM estradiol662863 2D-image
4'-hydroxy-2,5-dichlorobiphenylHomo sapiens-i.e. 4'-OH PCB 9, inhibition of SULT1A2673061 2D-image
4-chloro-3-methylphenolHomo sapiens-IC50: 0.024 mM, vs. 10 nM estradiol662863 2D-image
4-ChlorophenolHomo sapiens-IC50: 0.11 mM, vs. 10 nM estradiol662863 2D-image
4-hydroxy-2',3,5-trichlorobiphenylHomo sapiens-i.e. 4-OH PCB 34, substrate inhibition of SULT1A2673061 2D-image
5,7-dichlorokynurenic acidHomo sapiens, Mus musculus--702138-
adenosine 3',5'-bisphosphateHomo sapiens--645729 2D-image
androsteroneHomo sapiens-stronger substrate inhibition than dehydroepiandrosterone adenosine662232 2D-image
Cd2+Rattus norvegicus-strongly inhibited by 5 mM645722 2D-image
celecoxibHomo sapiens-heterotrophic modulator, 3-O-sulfation is inhibited by celecoxib to the same extent, independent of the concentration of 17alpha-ethynylestradiol, switches sulfation from the 3-O-position to the 17beta-O-position661577 2D-image
corticosteroneRattus norvegicus-competitive inhibitor, inhibits cortisol sulfotransferase activity645722 2D-image
cortisolRattus norvegicus--645722 2D-image
cortisoneRattus norvegicus--645722 2D-image
daidzeinDanio rerioQ7ZUS4IC50: 0.008 mM, competitive661469 2D-image
DCNPHomo sapiens--677143 2D-image
dehydroepiandrosteroneRattus norvegicus-competitive inhibitor, inhibits cortisol sulfotransferase activity645722 2D-image
dehydroepiandrosteroneHomo sapiens--662232 2D-image
dehydroepiandrosteroneHomo sapiens-i.e. DHEA, substrate inhibition of SULT1A2673061 2D-image
dehydroepiandrosteroneMus musculus-substrate inhibition677268 2D-image
deoxycorticosteroneRattus norvegicus-competitive inhibitor, inhibits cortisol sulfotransferase activity645722 2D-image
estradiolRattus norvegicus-substrate inhibition above 0.002 mM645727 2D-image
estradiol-17betaRattus norvegicus-competitive inhibitor, inhibits cortisol sulfotransferase activity645722 2D-image
gavestinelHomo sapiens, Mus musculus-i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt702138-
genisteinDanio rerioQ7ZUS4IC50: 0.0025 mM, competitive661469 2D-image
Kynurenic acidHomo sapiens-exhibits selective inhibitory effects on Sult1b1-mediated sulfation of various compounds with IC50 values in the low micromolar range702138 2D-image
Kynurenic acidMus musculus--702138 2D-image
L689,560Homo sapiens, Mus musculus-i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline702138-
L701,324Homo sapiens, Mus musculus-i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone702138-
p-hydroxymercuribenzoateRattus norvegicus--645722 2D-image
pregnenoloneHomo sapiens-substrate inhibition645729 2D-image
progesteroneRattus norvegicus-competitive inhibitor, inhibits cortisol sulfotransferase activity645722 2D-image
quercetinDanio rerioQ7ZUS4IC50: 0.0007 mM, competitive661469 2D-image
testosteroneRattus norvegicus-competitive inhibitor, inhibits cortisol sulfotransferase activity645722 2D-image
Zn2+Rattus norvegicus-strongly inhibited by 5 mM645722 2D-image
Mefenamic acidHomo sapiens, Mus musculus--702138 2D-image
additional informationRattus norvegicus-unaffected by 8 mM ADP, ATP, and AMP, diethylstilbestrol, cortisone and cholesterol are no inhibitors for the purified enzyme645722-
additional informationMus musculus-expression of SULT1A1 is reduced in Hep-G2 cells by farnesoid X receptor FXR agonists chenodeoxycholic acid and GW4064, chenodeoxycholic acid also decreases SULT2A expression in wild-type mice673311-
additional informationHomo sapiens-human pregnane X receptor, PXR, downregulates SULT2A1 gene expression, overview, CAR inhibites VDR-mediated vitamin D3 induction of SULT2A1 but notmethotrexate induction of SULT2A1674394-
additional informationSus scrofaQ3S3F7SULT2A1 activity is negatively correlated with 5alpha-androstenone concentrations in fat, overview675477-

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
celecoxibHomo sapiens-heterotrophic modulator, switches sulfation from the 3-O-position to the 17beta-O-position and activates such that the total sulfated product exceed product formation by the native enzyme, 3fold to 4fold at 0.25 mM celecoxib661577 2D-image
additional informationMus musculus-lithocholic acid induces SULT2A in wild-type and farnesoid X receptor-null mice, chenodeoxycholic acid induces the enzyme only in farnesoid X receptor-null mice, not in wild-type mice, overview673311-
additional informationHomo sapiens-SULT2A1 is a target gene for metabolic regulation/induction by thyroid hormone T3, T3 overexpressing cell s show increased SULT2A1 expression, indirect regulation mechanism via the transcription factor steroidogenic factor 1, SF1, overview673350-
additional informationMus musculus-induction of SULT2A1 expression by xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR, aging has no effect on the activity of an IR0 enhancer in the Sult2A1 chromatin to recruit VDR, RXR-alpha, and PXR in mice injected with D3 or PCN673838-
additional informationHomo sapiens-methotrexate induces SULT2A1 expression via nuclear receptor interactions, molecular mechanism, overview, the constitutive active receptor, CAR, mediates the methotrexate induction of SULT2A1 in both Caco-2 and Hep G2 cells, vitamin D receptor, VDR, also upregulates SULT2A1 gene expression, CAR inhibits VDR-mediated vitaminD3 induction of SULT2A1 but notmethotrexate induction of SULT2A1, overview674394-
additional informationHomo sapiens-enzyme induction by 1alpha,25-dihydroxyvitamin D3 via the vitamin D responsive element C/ERB-alpha, but not C/ERB-beta, coactivators p300, steroid receptor coactivator 1 and 2, SRC-1 and SRC-2, but not SRC-3, are also required, overview675998-
additional informationHomo sapiens-the enzyme promoter contains composite elements inducible by nuclear receptors pregnane X receptor and constitutive androstane receptor, synergizing effects by HNF4alpha binding at a site near the promoter, overview676007-

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.0012-1-NaphtholHomo sapiens-isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
0.191-17alpha-ethynylestradiolHomo sapiens--661577 2D-image
1e-05-17beta-estradiolHomo sapiens-pH 7.4, 37°C645734 2D-image
0.000125-17beta-estradiolCavia porcellus-pH 7.7, 37°C, 3-alphaHST isoform645736 2D-image
0.0091-17beta-estradiolDanio rerioQ6DHH8-660901 2D-image
0.013-17beta-estradiolDanio rerioQ7ZUS4-661469 2D-image
0.0014-24-epicathasteroneBrassica napus-pH 7.5, 25°C645737-
0.0049-24-epicathasteroneBrassica napusQ6T261pH 7.5, 25°C, BNST4663165-
0.003-24-epiteasteroneBrassica napusQ6T261pH 7.5, 25°C, BNST4663165 2D-image
0.0042-24-epiteasteroneBrassica napus-pH 7.5, 25°C645737 2D-image
0.0003-3'-phosphoadenylylsulfateHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme His-SULT2B1a645739 2D-image
0.0006-3'-phosphoadenylylsulfateHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme His-SULT2B1b645739 2D-image
0.0008-3'-phosphoadenylylsulfateHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme DHEA-ST645739 2D-image
0.00628-3'-phosphoadenylylsulfateRattus norvegicus-pH 6.8, 37.5°C645722 2D-image
0.0072-3'-phosphoadenylylsulfateHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme SULT2B1a645739 2D-image
0.0096-3'-phosphoadenylylsulfateHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme SULT2B1b645739 2D-image
0.0036-3,3',5-triiodothyronineDanio rerioQ7ZUS4-661469 2D-image
0.0209-3,4-Dihydroxyphenylacetic acidMus musculus-isoform Sult1d1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
0.00079-3alpha-tiboloneHomo sapiens-pH 6.0, 37°C, recombinant SULT1A1677143 2D-image
0.00056-3beta-tiboloneHomo sapiens-pH 7.0, 37°C, recombinant SULT1A1677143 2D-image
0.046-4-hydroxy-2',3,5-trichlorobiphenylHomo sapiens-pH 7.0, 37°C, recombinant SULT1A2673061 2D-image
0.0399-4-nitrophenolHomo sapiens-isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
0.00019-allopregnanoloneCavia porcellus-pH 7.7, 37°C, 3-alphaHST isoform645736 2D-image
0.012-androstenediolBrassica napusQ6T261pH 7.5, 25°C, BNST4663165 2D-image
0.00026-androsteroneCavia porcellus-pH 7.7, 37°C, 3-alphaHST isoform645736 2D-image
0.0021-androsteroneHomo sapiens-pH 7.5, 37°C662232 2D-image
0.00682-cortisolRattus norvegicus-pH 6.8, 37.5°C645722 2D-image
0.000788-dehydroepiandrosteroneCavia porcellus-pH 7.7, 37°C, 3-betaHST isoform645736 2D-image
0.0031-dehydroepiandrosteroneHomo sapiens-pH 7.5, 37°C662232 2D-image
0.0051-dehydroepiandrosteroneMus musculus-isoform SULT2A1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
0.02-dehydroepiandrosteroneBrassica napusQ6T261pH 7.5, 25°C, BNST4663165 2D-image
0.025-dehydroepiandrosteroneHomo sapiens-pH 7.0, 37°C, recombinant SULT1A2673061 2D-image
0.0016-dehydroepidandrosteroneHomo sapiens-pH 7.5, ?645729-
0.0019-dehydroepidandrosteroneHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme DHEA-ST645739-
0.0044-dehydroepidandrosteroneHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme His-SULT2B1a645739-
0.0093-dehydroepidandrosteroneHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme SULT2B1a645739-
0.0109-dehydroepidandrosteroneHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme His-SULT2B1b645739-
0.0185-dehydroepidandrosteroneHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme SULT2B1b645739-
0.238-despiramineMus musculus-isoform Sult2a1, in 50 mM Tris/HCl buffer, pH 10.0, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138-
0.00046-DiethylstilbestrolMus musculus-pH 7.9, 37°C645735 2D-image
0.0013-estradiolRattus norvegicus-pH 7.6, 37°C645727 2D-image
1.05e-05-estroneHomo sapiens-pH 7.4, 37°C645734 2D-image
0.0125-estroneDanio rerioQ7ZUS4-661469 2D-image
0.0235-estroneDanio rerioQ6DHH8-660901 2D-image
0.0283-n-propyl gallateDanio rerioQ6DHH8-660901 2D-image
0.00025-pregnenoloneCavia porcellus-pH 7.7, 37°C, 3-betaHST isoform645736 2D-image
0.0018-pregnenoloneHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme His-SULT2B1b645739 2D-image
0.0027-pregnenoloneHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme SULT2B1b645739 2D-image
0.003-pregnenoloneHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme His-SULT2B1a645739 2D-image
0.0049-pregnenoloneHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme DHEA-ST645739 2D-image
0.0072-pregnenoloneHomo sapiensO00204, Q06520pH 7.4, 37°C, isoenzyme SULT2B1a645739 2D-image
0.014-pregnenoloneBrassica napusQ6T261pH 7.5, 25°C, BNST4663165 2D-image
0.0002-testosteroneCavia porcellus-pH 7.7, 37°C, 3-alphaHST isoform645736 2D-image
0.0046-thyroxineDanio rerioQ7ZUS4-661469 2D-image
0.0063-xanthurenic acidHomo sapiens-isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
0.015-xanthurenic acidMus musculus-isoform Sult1d1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
0.206-xanthurenic acidHomo sapiens-isoform SULT1C2, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
0.145-L-triiodothyronineHomo sapiens-isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
additional information-additional informationHomo sapiens-for 4'-OH PCB 68, the limit of solubility makes the determination of kinetic constants difficult, the highest rate of sulfation is observed at the limit of solubility at about 0.05 mM673061-
additional information-additional informationHomo sapiens-the proline- and serine-rich carboxyl end is an important site in the immunogenicity, nuclear translocation, kinetic activity, and thermostability of SULT2B1b673295-
additional information-additional informationHomo sapiens-kinetics677143-

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.13-androsteroneHomo sapiens-pH 7.5, 37°C662232 2D-image
0.1-dehydroepiandrosteroneHomo sapiens-pH 7.5, 37°C662232 2D-image

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.253-4-hydroxy-2',3,5-trichlorobiphenylHomo sapiens-pH 7.0, 37°C, recombinant SULT1A2673061 2D-image
0.0016-adenosine 3',5'-bisphosphateHomo sapiens-pH 7.5645729 2D-image
0.0038-androsteroneHomo sapiens-pH 7.5, 37°C662232 2D-image
0.0106-dehydroepiandrosteroneHomo sapiens-pH 7.5, 37°C662232 2D-image
0.112-dehydroepiandrosteroneHomo sapiens-pH 7.0, 37°C, recombinant SULT1A2673061 2D-image

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.0007-2,3-dichlorophenolHomo sapiens-IC50: 0.0007 mM, vs. 10 nM estradiol662863 2D-image
0.0007-2,4-DichlorophenolHomo sapiens-IC50: 0.0007 mM, vs. 10 nM estradiol662863 2D-image
0.0022-2,5-dichlorophenolHomo sapiens-IC50: 0.0022 mM, vs. 10 nM estradiol662863 2D-image
0.0342-2,6-Dichloro-4-nitrophenolHomo sapiens-isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
24-2,6-Dichloro-4-nitrophenolHomo sapiens-isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
0.0016-2,6-dichlorophenolHomo sapiens-IC50: 0.0016 mM, vs. 10 nM estradiol662863 2D-image
0.02-2-chlorophenolHomo sapiens-IC50: 0.02 mM, vs. 10 nM estradiol662863 2D-image
0.0052-2-phenylphenolHomo sapiens-IC50: 0.0052 mM, vs. 10 nM estradiol662863 2D-image
0.013-3,4-dichlorophenolHomo sapiens-IC50: 0.013 mM, vs. 10 nM estradiol662863 2D-image
0.017-3,5-dichlorophenolHomo sapiens-IC50: 0.017 mM, vs. 10 nM estradiol662863 2D-image
0.13-3-chlorophenolHomo sapiens-IC50: 0.13 mM, vs. 10 nM estradiol662863 2D-image
0.0039-4'-hydroxy-2,5-dichlorobiphenylHomo sapiens-pH 7.0, 37°C, recombinant SULT1A2673061 2D-image
0.024-4-chloro-3-methylphenolHomo sapiens-IC50: 0.024 mM, vs. 10 nM estradiol662863 2D-image
0.11-4-ChlorophenolHomo sapiens-IC50: 0.11 mM, vs. 10 nM estradiol662863 2D-image
0.1642-5,7-dichlorokynurenic acidHomo sapiens-isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138-
0.2536-5,7-dichlorokynurenic acidHomo sapiens-isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138-
0.008-daidzeinDanio rerioQ7ZUS4IC50: 0.008 mM, competitive661469 2D-image
0.0012-gavestinelHomo sapiens-isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138-
0.0017-gavestinelHomo sapiens-isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138-
0.0025-genisteinDanio rerioQ7ZUS4IC50: 0.0025 mM, competitive661469 2D-image
0.0337-Kynurenic acidHomo sapiens-isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
9-Kynurenic acidHomo sapiens-isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
0.0473-L689,560Homo sapiens-isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138-
0.0536-L689,560Homo sapiens-isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138-
0.005-Mefenamic acidHomo sapiens-IC50 above 0.005 mM, isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C; IC50 above 0.005 mM, isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C702138 2D-image
0.0007-quercetinDanio rerioQ7ZUS4IC50: 0.0007 mM, competitive661469 2D-image

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
0.00071-Rattus norvegicus--645727
0.000831-Rattus norvegicus--645728
0.000978-Rattus norvegicus--645722
0.0035-Rattus norvegicus--645730
0.0041-Danio rerioQ6DHH8activity with caffeic acid660901
0.0046-Danio rerioQ6DHH8activity with catechin660901
0.0059-Danio rerioQ6DHH8activity with chlorogenic acid660901
0.0066-Danio rerioQ6DHH8activity with p-nitrophenol660901
0.0073-Homo sapiens--645723
0.0108-Danio rerioQ6DHH8activity with butylated hydroxy anisole660901
0.0154-Danio rerioQ6DHH8activity with daidzein660901
0.0165-Danio rerioQ6DHH8activity with kaempferol660901
0.0175-Danio rerioQ6DHH8activity with quercetin660901
0.0175-Homo sapiens-purified recombinant SULT1A2, substrate 4'-hydroxy-2,3',4,5'-tetrachlorobiphenyl673061
0.0184-Danio rerioQ6DHH8activity with genistein660901
0.0191-Danio rerioQ6DHH8activity with 17beta-estradiol660901
0.0201-Homo sapiens--645724
0.0265-Danio rerioQ6DHH8activity with myricetin660901
0.027-Homo sapiens-purified recombinant SULT1A2, substrate 4-hydroxy-2',3,5-trichlorobiphenyl673061
0.0283-Danio rerioQ6DHH8activity with epigallocatechin gallate660901
0.0302-Danio rerioQ6DHH8activity with estrone660901
0.0345-Danio rerioQ6DHH8activity with n-propyl gallate660901
0.038-Danio rerioQ6DHH8activity with beta-naphthol660901
0.0805-Danio rerioQ7ZUS4reaction with estrone661469
0.0916-Danio rerioQ7ZUS4reaction with 17beta-estradiol661469
0.133-Homo sapiens--645729
additional information-Mus musculus-determination of 3alpha-sulfated bile acids677268

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
5.56Rattus norvegicus--645727
5.56Cavia porcellus-3alphahydroxysteroid activity645736
5.5-Rattus norvegicus-substrate estradiol645727
67Homo sapiens-assay at677143
6-Rattus norvegicus--645722
6-Rattus norvegicus-substrate estrone645727
6.57Cavia porcellus-3betahydroxysteroid activity645736
6.5-Danio rerioQ6DHH82 optima: pH 6.5 and pH 10-10.5, activity with estrone and n-propyl gallate660901
6.8-Homo sapiens--645724
78Rattus norvegicus-biphasic pH optimum, activity for estradiol, but not estrone645727
7-Homo sapiens-assay at673061
7.4-Sus scrofaQ3S3F7assay at675477
7.5-Homo sapiens-assay at673295
8-Sus scrofa--645725
1010.5Danio rerioQ6DHH82 optima: pH 6.5 and pH 10-10.5, activity with estrone and n-propyl gallate660901

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
59Rattus norvegicus--645727
7.59.3Sus scrofa--645725

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
37-Sus scrofa--645725
37-Homo sapiens-assay at673061, 673295
37-Sus scrofaQ3S3F7assay at675477
37-Homo sapiens-assay at677143

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
2045Sus scrofa--645725

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
adipose tissueSus scrofaQ3S3F7SULT2A1675477Manually annotated by BRENDA team
adrenal cortexHomo sapiens--645723, 645739Manually annotated by BRENDA team
adrenal glandHomo sapiens--645723, 645733Manually annotated by BRENDA team
adrenal glandHomo sapiens-foetal645724Manually annotated by BRENDA team
adrenal glandCavia porcellus--645733, 645736Manually annotated by BRENDA team
adrenal glandBos taurus--645733Manually annotated by BRENDA team
adrenal glandHomo sapiens-fetal, and adult adrenal reticular layer as well as adrenal cortex, SULT2A1676256Manually annotated by BRENDA team
aortaHomo sapiens-aortic smooth muscle cell line CRL-1999645740Manually annotated by BRENDA team
blood plasmaSus scrofa--661953Manually annotated by BRENDA team
brainRattus norvegicus--645730Manually annotated by BRENDA team
CACO-2 cellHomo sapiens--676007Manually annotated by BRENDA team
chorionCavia porcellus--645732Manually annotated by BRENDA team
endometrial cell lineHomo sapiens-Ishikawa adenocarcinoma645734Manually annotated by BRENDA team
epidermal cellMus musculus--706919Manually annotated by BRENDA team
fetusHomo sapiens-foetal tissue is a much richer source of enzyme than adult645724Manually annotated by BRENDA team
Hep-G2 cellHomo sapiens--673350, 675998, 676007Manually annotated by BRENDA team
intestineHomo sapiens--675998Manually annotated by BRENDA team
keratinocyteHomo sapiens-epidermal, primary cultures662582Manually annotated by BRENDA team
kidneyRattus norvegicus--645730Manually annotated by BRENDA team
liverRattus norvegicus--645722, 645726, 645727, 645728, 645730, 645733Manually annotated by BRENDA team
liverHomo sapiens--645729, 645733, 645739, 662863, 673350, 675998Manually annotated by BRENDA team
liverHomo sapiens-isoenzyme in adult liver645731Manually annotated by BRENDA team
liverCavia porcellus--645733, 645736Manually annotated by BRENDA team
liverBos taurus--645733Manually annotated by BRENDA team
liverMus musculus--645735, 677268Manually annotated by BRENDA team
liverMus musculus-SULT2A levels in liver are 8fold higher in farnesoid X receptor-null micethan in wild-type mice673311Manually annotated by BRENDA team
liverMus musculus-of 4-month- and 20-month-old mice, SULT2A1 expression analysis, overview673838Manually annotated by BRENDA team
liverSus scrofaQ3S3F7SULT2A1675477Manually annotated by BRENDA team
liverHomo sapiens-SULT2A1676256Manually annotated by BRENDA team
liverHomo sapiens-postmenopausal, SULT2A1677143Manually annotated by BRENDA team
lungHomo sapiens-SULT2B1b660966Manually annotated by BRENDA team
lungHomo sapiens-; SULT2B1b, ciliated columnar or cuboid epithelial cells in terminal bronchia, not in alveolar cells661253Manually annotated by BRENDA team
muscleHomo sapiens-aortic smooth muscle cell line CRL-1999645740Manually annotated by BRENDA team
placentaBos taurus, Homo sapiens--645733Manually annotated by BRENDA team
placentaHomo sapiensO00204, Q06520SULT2B1645739Manually annotated by BRENDA team
placentaHomo sapiens-SULT2B1b660966Manually annotated by BRENDA team
primary cellMus musculus--706919Manually annotated by BRENDA team
prostateCavia porcellus-small but detectable amount of 3alphaHST activity645736Manually annotated by BRENDA team
prostateHomo sapiensO00204, Q06520SULT2B1645739Manually annotated by BRENDA team
prostateHomo sapiens-SULT2B1b660966Manually annotated by BRENDA team
seedlingBrassica napus--645737, 663165Manually annotated by BRENDA team
skinHomo sapiens-SULT2B1b660966Manually annotated by BRENDA team
skinHomo sapiens-localization is confined to the granular layer of the epidermis662582Manually annotated by BRENDA team
skinMus musculus-in the basement layer of normal skin706919Manually annotated by BRENDA team
small intestineCavia porcellus--645736Manually annotated by BRENDA team
small intestineHomo sapiens-postmenopausal, SULT2A1677143Manually annotated by BRENDA team
testicular veinSus scrofa--661953Manually annotated by BRENDA team
testisSus scrofaQ3S3F7SULT2A1675477Manually annotated by BRENDA team
uterusCavia porcellus--645732Manually annotated by BRENDA team
uterusMus musculus--645735Manually annotated by BRENDA team
MCF-7 cellHomo sapiens--675275Manually annotated by BRENDA team
additional informationCavia porcellus-both 3alphaHST and 3betaHST activities are essentially undetectable in the testis645736Manually annotated by BRENDA team
additional informationHomo sapiensO00204, Q06520no SULT2B1 in liver, colon, lung, kidney, brain, or testis645739Manually annotated by BRENDA team
additional informationHomo sapiens-variant haplotypes in tissues possessing alterations in activity or stability may alter the plasma levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate thereby altering the conversion of dehydroepiandrosterone in tissues, overview676256Manually annotated by BRENDA team
additional informationMus musculus-farnesoid X receptor FXR-null mice express a constitutively high level of SULT2A677268Manually annotated by BRENDA team

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
cytoplasmRattus norvegicus--5737645722, 645726Manually annotated by BRENDA team
cytoplasmSus scrofa--5737645725Manually annotated by BRENDA team
cytoplasmHomo sapiens-epithelial cells in prostate tissue, of LNCaP prostate cancer cells5737660966Manually annotated by BRENDA team
cytoplasmHomo sapiens--5737661253Manually annotated by BRENDA team
cytosolRattus norvegicus--5829645722, 645727, 645733Manually annotated by BRENDA team
cytosolHomo sapiens--5829645723, 645724, 645729, 645731, 645733, 645739, 662863, 702138Manually annotated by BRENDA team
cytosolSus scrofa--5829645725, 675477Manually annotated by BRENDA team
cytosolCavia porcellus--5829645732, 645733, 645736Manually annotated by BRENDA team
cytosolMus musculus--5829645735, 677268, 702138, 706919Manually annotated by BRENDA team
cytosolDanio rerio--5829660901, 661469Manually annotated by BRENDA team
cytosolHomo sapiens-of ciliated columnar or cuboid epithelial cells in terminal bronchia, SULT2B1b5829661253Manually annotated by BRENDA team
cytosolHomo sapiens-truncated mutant SULT2B1b lacking the proline- and serine-rich carboxyl end5829673295Manually annotated by BRENDA team
endoplasmic reticulumHomo sapiens--5783645729Manually annotated by BRENDA team
Golgi apparatusHomo sapiens--5794645729Manually annotated by BRENDA team
membraneHomo sapiens--16020645729Manually annotated by BRENDA team
membraneCavia porcellus--16020645732Manually annotated by BRENDA team
nucleusHomo sapiens-of placental syncytiotrophoblasts, term human placenta. Human prostate shows only cytosolic localization of SULT2b1 in the basal and luminal prostate epithelial cells. SULT2B1b is capable of translocating to nuclei in BeWo placental cells after stable transfection and differentiation5634660966Manually annotated by BRENDA team
nucleusHomo sapiens-full-length SULT2B1b, the proline- and serine-rich carboxyl end is an important site in the immunogenicity, nuclear translocation, kinetic activity, and thermostability of SULT2B1b5634673295Manually annotated by BRENDA team
nucleusHomo sapiens--5634673350Manually annotated by BRENDA team
nucleusMus musculus--5634673838Manually annotated by BRENDA team

PDBSCOPCATHORGANISM
No entries in this field

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
32500-Rattus norvegicus--645728
32500-Rattus norvegicus-gel filtration645730
33000-Homo sapiens-immunoblot analysis, antibodies against rat liver sulfotransferases645731
39620-Homo sapiensO00204, Q06520isoform SULT2B1a645739
41300-Homo sapiensO00204, Q06520isoform SULT2B1b645739
6000070000Rattus norvegicus-gel filtration645728
61500-Rattus norvegicus-gel filtration645722
65000-Rattus norvegicus-sedimentation velocity experiment in preparative ultracentrifuge645722
6800070000Homo sapiens-gel filtration645729
68000-Homo sapiens-sucrose density gradient ultracentrifugation645723, 645724

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
?Danio rerioQ6DHH8x * 62000, SDS-PAGE660901
dimerHomo sapiens-2 * 34500, SDS-PAGE; 2 * 35000, amino acid analysis; 2 * 35000, SDS-PAGE645723
dimerHomo sapiens-2 * 34000, SDS-PAGE645724
dimerRattus norvegicus-1 * 32500 + 29500, SDS-PAGE645727
dimerHomo sapiens--645729
monomerRattus norvegicus-1 * 32500, SDS-PAGE645728, 645730
monomerMus musculus-1 * 37600, recombinant protein, SDS-PAGE645735
additional informationHomo sapiens-isozyme SULT2B1b has an extension at the proline- and serine-rich carboxyl end of about 53 amino acids673295

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
phosphoproteinHomo sapiens-the the proline- and serine-rich carboxyl end of SULT2B1 is phosphorylated at serine residues, e.g. by casein kinase or Cdc2 protein kinase in vitro673295

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
hanging drop vapor diffusion technique, structure of human dehydroepiandrosterone adenosine sulfotransferase in complex with androsterone has been solved at 2.7 A resolutionHomo sapiens-662232

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
42-Homo sapiens-after 30 min, dehydroepiandrosterone sulfation activity with recombinant truncated SULT2B1b is decreased 3.5fold more than that of recombinant full-length SULT2B1b, after 45 min,the truncated SULT2B1b activity is completely eliminated, whereas full-length SULT2B1b still maintains about 70% of its original activity673295
additional information-Homo sapiens-the proline- and serine-rich carboxyl end is an important site in the immunogenicity, nuclear translocation, kinetic activity, and thermostability of SULT2B1b673295

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
marked instability, addition of 20% glycerol improves stabilityRattus norvegicus-645728

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-70°C, stored in glass ampoules , 0.05 M Tris-HCl buffer, pH 7.5, 0.1 mM DTT, 2% propylene glycol, 1 mg/ml protein, no significant difference in activity observed after storage for 3.5 monthsHomo sapiens-645724
0°C, redialyzed againstTris/thiol buffer, stored under N2, activity retains for at least 4 weeksHomo sapiens-645723
-20°C, partially purified enzyme, stable for at least 3 monthsRattus norvegicus-645722
-20°C, storage for up to 2 months results in no decrease in activitySus scrofa-645725

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
recombinant enzyme, expressed in Escherichia coliBrassica napus-645737
TSTCavia porcellus-645736
-Danio rerio-660901, 661469
-Homo sapiens-645723, 645724, 645729, 645731
Ni-NTA agarose column chromatographyHomo sapiens-702138
recombinant enzyme, expressed in Escherichia coliHomo sapiens-645738
recombinant His-tagged full-length SULT2B1b as well as truncated SULT2B1b without the PSC extension from Escherichia coli strain DH5alpha by nickel affinity chromatographyHomo sapiens-673295
SULT2B1Homo sapiensO00204, Q06520645739
Ni-NTA agarose column chromatographyMus musculus-702138
Ni-NTA column chromatographyMus musculus-706919
recombinant His-tagged SULT2A1 from Escherichia coli by nickel affinity chromatography, expression analysisMus musculus-673311
-Rattus norvegicus-645726, 645728
male-specific enzymeRattus norvegicus-645730
partialRattus norvegicus-645722, 645727
partialSus scrofa-645725

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
expression in Escherichia coliBrassica napusQ6T261663165
genomic library constructed in pTZ18R, expression of recombinant BNST3 in Escherichia coliBrassica napus-645737
-Cavia porcellus-645733
3alphaHST and 3betaHST cDNA cloned and overexpressed in Escherichia coliCavia porcellus-645736
expressed in Escherichia coli BL21 using the pGEX-2TK expression systemDanio rerioQ6DHH8660901
; ; SULT2B1 gene encodes 2 isoforms, SULT2B1a and SULT2B1b, generated by alternate splicing of the first exon, cloned and expressed in Escherichia coliHomo sapiensO00204, Q06520645739
baculovirus expression-system, expression in Sf9 cellsHomo sapiens-661577
cDNA for isozymes STS and EST clonedHomo sapiens-645740
cloning of 5'-flanking region of SULT2A1 and expression of a SULT2A1-reporter construct in Caco-2 cells, transcriptional regulation mechanism analysis, co-expression of human nuclear receptors constitutive androstane receptor CAR and retinoid X receptor alpha RXRalpha which are involved in the regulation, electrophoretic mobility shift assay for interaction study, overviewHomo sapiens-677218
DHEA-ST cDNA cloned and sequenced from human adrenal cDNA library, expression vectors transfected into 293 cells, gene hEST, Hugo nomenclature named it STM gene, because it also codes for monoamine-sulfating phenolsulfotransferase M-PSTHomo sapiens-645733
enzyme expression induction by 1alpha,25-dihydroxyvitamin D3 via the vitamin D responsive element C/ERB-alpha, but not C/ERB-beta, coactivators p300, steroid receptor coactivator 1 and 2, SRC-1 and SRC-2, but not SRC-3, are also required, regulation of transcription and translation, overview, co-expression of SULT2A1 with C/ERB-alpha and 1alpha,25-dihydroxyvitamin D3 in murine NIH3T3 cellsHomo sapiens-675998
expressed in Escherichia coli BL21(DE3) cellsHomo sapiens-702138
expression and expression analysis of wild-type and mutant SULT2A1Homo sapiens-676256
expression of His-tagged full-length SULT2B1b and truncated SULT2B1b without the PSC extension in Escherichia coli strain DH5alpha and in human BeWo choriocarcinoma cells, translocation of the wild-type enzyme to nuclei, but not of the truncation mutantHomo sapiens-673295
expression of SULT1A2 in Escherichia coli strain BL21 (DE3)Homo sapiens-673061
expression of SULT2B1b eliminates the cytotoxic effect of 7-oxo-cholesterol on 293T cells, which are normally devoid of SULT2B1bHomo sapiens-675275
gene SULT2A1, expression and regulation analysis, the enzyme promoter contains composite elements inducible by nuclear receptors pregnane X receptor, PXR, and constitutive androstane receptor, CAR, synergizing effects by HNF4alpha binding at a site near the promoter, overviewHomo sapiens-676007
hEST1 and hEST2 cloned and overexpressed in Escherichia coli in fusion with GSTHomo sapiens-645738
SULT2A1 is a target gene for metabolic regulation/induction by thyroid hormone T3, T3 overexpressing Hep-G2 cells, with co-expression of the T3-receptor-alpha, show increased SULT2A1 expression in a DNA microarray analysis, 5fold at protein level and 9fold at mRNA level, which is inhibited by cycloheximide indicating an indirect regulation mechanism via the transcription factor steroidogenic factor 1, SF1, SULT2A1 contains seven SF1 binding sites, analysis of promoter activity in wild-type and truncation mutants of the enzyme, overviewHomo sapiens-673350
SULT2A1, determination of the promoter sequence, SULT2A1-reporter gene expression in Hep-G2 cells and expression analysis, the constitutive active receptor, CAR, mediates the methotrexate induction of SULT2A1 in both Caco-2 andHep G2 cells, vitamin D receptor, VDR, also upregulates SULT2A1 gene expression, while human pregnane X receptor, PXR, downregulates itHomo sapiens-674394
3 isoenzymes cloned and expressed in Escherichia coliMus musculus-645735
expressed in Escherichia coli BL21(DE3) cellsMus musculus-702138
expressed in Escherichia coli strain M15Mus musculus-706919
expression analysis of SULT2A1, induction of SULT2A1 expression by xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR, aging has no effect on the activity of an IR0 enhancer in the Sult2A1 chromatin to recruit VDR, RXR-alpha, and PXR in mice injected with D3 or PCNMus musculus-673838
expression of His-tagged SULT2A in Escherichia coliMus musculus-673311
SULT2A1, DNA and amino acid sequence determination and analysis, relationship between SULT2A1 expression and sulfoconjugation of androstenone, quantitative expression analysis, overview, identification of nuclear receptors involved in regulating SULT2A1Sus scrofaQ3S3F7675477

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
highest expression level is detected in epidermis from 3-day-old mice and then decreases before maturationMus musculus-706919

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
A679GHomo sapiens-naturally occuring polymorphisms of SULT2A1, genotyping, SULT2A1 variant allele frequencies in African-American populations, overview676256
G187CHomo sapiens-naturally occuring polymorphisms of SULT2A1, genotyping, SULT2A1 variant allele frequencies in African-American populations, overview676256
G781AHomo sapiens-naturally occuring polymorphisms of SULT2A1, genotyping, SULT2A1 variant allele frequencies in African-American populations, overview676256
additional informationHomo sapiens-construction of a SULT2B1b truncation mutant lacking the proline- and serine-rich carboxyl end of about 53 amino acids, removal of the PSC extension significantly decreases the thermostability of the expressed enzyme and the rate of dehydroepiandrosterone sulfation, truncated SULT2B1b is incapable of translocation to nuclei in transfected human BeWo choriocarcinoma cells673295
additional informationHomo sapiens-construction of truncation mutants of SULT2A1 for analysis of SF1 binding sites and promoter activity, overview673350
additional informationHomo sapiens-disruption of the DR4-type motif and the IR2-type motif prevents in vitro binding of nuclear receptors pregnane X receptor and constitutive androstane receptor to their specific binding sites, overview676007
additional informationMus musculus-farnesoid X receptor FXR-null mice express a constitutively high level of SULT2A677268

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
medicineHomo sapiens-characterization of the mechanism of regulation and action of DHEA-ST should lead to a better understanding of the control of adrenal androgen production as well as a better knowledge of the role of DHEAS in the androgen-and estrogen-sensitive disorders645733
medicineHomo sapiens-isoenzyme STS plays important roles in regulating the in situ production of estrogens in breast carcinoma tissue, immunoreactivity of the enzymes is a potent prognostic factor for cancer645741

DISEASETITLE OF PUBLICATIONLINK TO PUBMED
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiencyPremature adrenarche: novel lessons from early onset androgen excess. PubMed
AdenocarcinomaCloning and expression of cDNA encoding human placental estrogen sulfotransferase. PubMed
AdenocarcinomaInhibition of SULT2B1b expression alters effects of 3beta-hydroxysteroids on cell proliferation and steroid hormone receptor expression in human LNCaP prostate cancer cells. PubMed
AdenocarcinomaSulfotransferase 2B1b in human breast: differences in subcellular localization in African American and Caucasian women. PubMed
AdenomaImmunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland. PubMed
Adrenocortical AdenomaImmunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland. PubMed
Adrenocortical CarcinomaImmunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland. PubMed
Breast NeoplasmsDifferent subcellular localization of sulphotransferase 2B1b in human placenta and prostate. PubMed
Breast NeoplasmsHigh metabolization of catecholestrogens by type 1 estrogen sulfotransferase (hEST1). PubMed
Breast NeoplasmsRelationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma. PubMed
CarcinomaDifferent subcellular localization of sulphotransferase 2B1b in human placenta and prostate. PubMed
CarcinomaEndocrine steroid sulfotransferases: steroid alcohol sulfotransferase from human breast carcinoma cell line MCF-7. PubMed
CarcinomaImmunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland. PubMed
CarcinomaInhibitory effects of sulfation inhibitors on initiation of pancreatic ductal carcinogenesis by N-nitrosobis(2-oxopropyl)amine in hamsters. PubMed
CarcinomaThe steroid alcohol and estrogen sulfotransferases in rodent and human mammary tumors. PubMed
Carcinoma, HepatocellularDown-regulation of dehydroepiandrosterone sulfotransferase gene in human hepatocellular carcinoma. PubMed
ChoriocarcinomaCharacterization of Proline-Serine-Rich Carboxyl Terminus in Human Sulfotransferase 2B1b: Immunogenicity, Subcellular Localization, Kinetic Properties, and Phosphorylation. PubMed
ChoriocarcinomaHuman cytosolic sulfotransferase 2B1: isoform expression, tissue specificity and subcellular localization. PubMed
Communicable DiseasesInfluenza A virus infection activates cholesterol sulfotransferase (SULT2B1b) in the lung of female C57BL/6 mice. PubMed
Cushing SyndromeSerum levels of dehydroepiandrosterone sulfate in patients with asymptomatic cortisol producing adrenal adenoma: comparison with adrenal Cushing's syndrome and non-functional adrenal tumor. PubMed
Endometrial NeoplasmsDisturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: Lower levels of CYP1B1 and increased expression of S-COMT. PubMed
GliomaRegulation of SULT2B1a (pregnenolone sulfotransferase) expression in rat C6 glioma cells: relevance of AMPA receptor-mediated NO signaling. PubMed
Hepatitis, Chronic17Beta-hydroxysteroid dehydrogenase type 2 and dehydroepiandrosterone sulfotransferase in the human liver. PubMed
Herpes ZosterDehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. PubMed
Herpes ZosterDevelopmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies. PubMed
Herpes ZosterHuman dehydroepiandrosterone sulfotransferase. Purification, molecular cloning, and characterization. PubMed
Herpes ZosterImmunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland. PubMed
HyperlipidemiasOxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease. PubMed
HyperthyroidismSerum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism. PubMed
InfectionInfluenza A virus infection activates cholesterol sulfotransferase (SULT2B1b) in the lung of female C57BL/6 mice. PubMed
InfectionOxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease. PubMed
Influenza, HumanInfluenza A virus infection activates cholesterol sulfotransferase (SULT2B1b) in the lung of female C57BL/6 mice. PubMed
NeoplasmsDehydroepiandrosterone sulfotransferase as a possible shunt for the control of steroid metabolism in human mammary carcinoma. PubMed
NeoplasmsEstrogen receptor and C19-5-ene-steroid concentrations in the nuclear fraction from human breast carcinoma tissue. PubMed
NeoplasmsInvolvement of prostaglandin E2 in the tumor promoter phorbol ester-caused increase in epidermal cholesterol sulfotransferase activity. PubMed
NeoplasmsThe steroid alcohol and estrogen sulfotransferases in rodent and human mammary tumors. PubMed
NeoplasmsTumor Necrosis Factor-Alpha-Nuclear Factor-Kappa B-Signaling Enhances St2b2 Expression during 12-O-Tetradecanoylphorbol-13-acetate-Induced Epidermal Hyperplasia. PubMed
NeoplasmsTumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. PubMed
ObesityObesity genes and diabetes induction in the mouse. PubMed
Prostatic NeoplasmsDifferent subcellular localization of sulphotransferase 2B1b in human placenta and prostate. PubMed
Prostatic NeoplasmsInhibition of SULT2B1b expression alters effects of 3beta-hydroxysteroids on cell proliferation and steroid hormone receptor expression in human LNCaP prostate cancer cells. PubMed
SepsisDissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock. PubMed
steroid sulfotransferase deficiencyPremature adrenarche: novel lessons from early onset androgen excess. PubMed
ViremiaGenetic variations in humans associated with differences in the course of hepatitis C. PubMed

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISMLINK TO PUBMEDSOURCE
645722Singer, S.S.; Gebhart, J.; Hess, E.Enzymatic sulfation of steroids. V. Partial purification and some properties of sulfotransferase III, the major glucocorticoid sulfotransferase of liver cytosol from male ratsCan. J. Biochem.561028-10351978Rattus norvegicus PubMed
645723Adams, J.B.; McDonald, D.Enzymic synthesis of steroid sulphates. XII. Isolation of dehydroepiandrosterone sulphotransferase from human adrenals by affinity chromatographyBiochim. Biophys. Acta567144-1531979Homo sapiens PubMed
645724Adams, J.B.; McDonald, D.Enzymic synthesis of steroid sulphates. XIII. Isolation and properties of dehydroepiandrosterone sulphotransferase from human foetal adrenalsBiochim. Biophys. Acta615275-2781980Homo sapiens PubMed
645725Gower, D.B.; Cooke, G.M.; Ferguson, S.E.Sulphoconjugation of steroids in porcine liver. Partial purification of the cytosolic sulphotransferases for pregnenolone and 5alpha-androst-16-en-3beta-olFEBS Lett.150507-5101982Sus scrofa PubMed
645726Singer, S.S.; Federspiel, M.J.; Green, J.; Lewis, W.G.; Martin, V.; Witt, K.R.; Tappel, J.Enzymatic sulfation of steroids. XV. Studies differentiating between rat liver androgen, estrogen, bile acid, glucocorticoid and phenol sulfotransferasesBiochim. Biophys. Acta700110-1171982Rattus norvegicus PubMed
645727Sugiyama, Y.; Stolz, A.; Sugimoto, M.; Kuhlenkamp, J.; Yamada, T.; Kaplowitz, N.Identification and partial purification of a unique phenolic steroid sulphotransferase in rat liver cytosolBiochem. J.224947-9531984Rattus norvegicus PubMed
645728Takikawa, H.; Stolz, A.; Kaplowitz, N.Purification of a 32.5 kDa monomeric sulfotransferase from rat liver with activity for bile acids and phenolic steroidsFEBS Lett.207193-1971986Rattus norvegicus PubMed
645729Falany, C.N.; Vasquez, M.E.; Kalb, J.M.Purification and characterization of human liver dehydroepiandrosterone sulphotransferaseBiochem. J.260641-6461989Homo sapiens PubMed
645730Borthwick, E.B.; Burchell, A.; Coughtrie, M.W.H.Purification and immunochemical charcterization of a male-specific rat liver oestrogen sulphotransferaseBiochem. J.289719-7251993Rattus norvegicus-
645731Forbes-Bamforth, K.J.; Coughtrie, M.W.H.Identification of a new adult human liver sulfotransferase with specificity for endogenous and xenobiotic estrogensBiochem. Biophys. Res. Commun.198707-7111994Homo sapiens PubMed
645732Hobkirk, R.Sulfation by guinea pig chorion and uterus: Differential action towards estrone and estradiolJ. Steroid Biochem. Mol. Biol.59479-4841996Cavia porcellus PubMed
645733Luu-The, V.; Bernier, F.; Dufort, I.Steroid sulfotransferasesJ. Endocrinol.15087-971996Bos taurus, Cavia porcellus, Homo sapiens, Rattus norvegicus PubMed
645734Chetrite, G.; Pasqualini, J.R.Steroid sulphotransferase and 17beta-hydroxysteroid dehydrogenase activities in Ishikawa human endometrial adenocarcinoma cellsJ. Steroid Biochem. Mol. Biol.6127-341997Homo sapiens PubMed
645735Kakuta, Y.; Pedersen, L.C.; Chae, K.; Song, W.C.; Leblanc, D.; London, R.; Carter, C.W.; Negishi, M.Mouse steroid sulfotransferases. Substrate specificity and preliminary X-ray crystallographic analysisBiochem. Pharmacol.55313-3171998Mus musculus PubMed
645736Park, B.C.; Lee, Y.C.; Strott, C.A.Testosterone sulfotransferase: Evidence in the guinea pig that this reaction is carried out by 3alpha-hydroxysteroid sulfotransferaseSteroids64510-5171999Cavia porcellus PubMed
645737Rouleau, M.; Marsolais, F.; Richard, M.; Nicolle, L.; Voigt, B.; Adam, G.; Varin, L.Inactivation of brassinosteroid biological activity by a salicylate-inducible steroid sulfotransferase from Brassica napusJ. Biol. Chem.27420925-209301999Brassica napus PubMed
645738Faucher, F.; Lacoste, L.; Dufort, I.; Luu-The, V.High metabolization of catecholestrogens by type 1 estrogen sulfotransferase (hEST1)J. Steroid Biochem. Mol. Biol.7783-862001Homo sapiens PubMed
645739Meloche, C.A.; Falany, C.N.Expression and characterization of the human 3b-hydroxysteroid sulfotransferases (SULT2B1alpha and SULT2B1beta)J. Steroid Biochem. Mol. Biol.77261-2692001Homo sapiens PubMed
645740Nakamura, Y.; Miki, Y.; Suzuki, T.; Nakata, T.; Darnel, A.D.; Moriya, T.; Tazawa, C.; Saito, H.; Ishibashi, T.; Takahashi, S.; Yamada, S.; Sasano, H.Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aortaAm. J. Pathol.1631329-13392003Homo sapiens PubMed
645741Suzuki, T.; Nakata, T.; Miki, Y.; Kaneko, C.; Moriya, T.; Ishida, T.; Akinaga, S.; Hirakawa, H.; Kimura, M.; Sasano, H.Estrogen sulfotransferase and steroid sulfatase in human breast carcinomaCancer Res.632762-27702003Homo sapiens PubMed
660901Yasuda, S.; Liu, C.C.; Takahashi, S.; Suiko, M.; Chen, L.; Snow, R.; Liu, M.C.Identification of a novel estrogen-sulfating cytosolic SULT from zebrafish: molecular cloning, expression, characterization, and ontogeny studyBiochem. Biophys. Res. Commun.330219-2252005Danio rerio PubMed
660966He, D.; Meloche, C.A.; Dumas, N.A.; Frost, A.R.; Falany, C.N.Different subcellular localization of sulfotransferase 2B1b in human placenta and prostateBiochem. J.379533-5402004Homo sapiens PubMed
661253He, D.; Frost, A.R.; Falany, C.N.Identification and immunohistochemical localization of sulfotransferase 2B1b (SULT2B1b) in human lungBiochim. Biophys. Acta1724119-1262005Homo sapiens PubMed
661469Ohkimoto, K.; Liu, M.Y.; Suiko, M.; Sakakibara, Y.; Liu, M.C.Characterization of a zebrafish estrogen-sulfating cytosolic sulfotransferase: inhibitory effects and mechanism of action of phytoestrogensChem. Biol. Interact.1471-72004Danio rerio PubMed
661577Cui, D.; Booth-Genthe, C.L.; Carlini, E.; Carr, B.; Schrag, M.L.Heterotropic modulation of sulfotransferase 2A1 activity by celecoxib: product ratio switching of ethynylestradiol sulfationDrug Metab. Dispos.321260-12642004Homo sapiens PubMed
661953Sinclair, P.A.; Squires, E.J.Testicular sulfoconjugation of the 16-androstene steroids by hydroxysteroid sulfotransferase: its effect on the concentrations of 5alpha-androstenone in plasma and fat of the mature domestic boarJ. Anim. Sci.83358-3652005Sus scrofa PubMed
662232Chang, H.J.; Shi, R.; Rehse, P.; Lin, S.X.Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complexJ. Biol. Chem.2792689-26962004Homo sapiens PubMed
662582Higashi, Y.; Fuda, H.; Yanai, H.; Lee, Y.; Fukushige, T.; Kanzaki, T.; Strott, C.A.Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytesJ. Invest. Dermatol.1221207-12132004Homo sapiens PubMed
662863Harris, R.M.; Kirk, C.J.; Waring, R.H.Non-genomic effects of endocrine disrupters: inhibition of estrogen sulfotransferase by phenols and chlorinated phenolsMol. Cell. Endocrinol.24472-742005Homo sapiens PubMed
663165Marsolais, F.; Sebastia, C.H.; Rousseau, A.; Varin, L.Molecular and biochemical characterization of BNST4, an ethanol-inducible steroid sulfotransferase from Brassica napus, and regulation of BNST genes by chemical stress and during developmentPlant Sci.1661359-13702004Brassica napus-
673061Liu, Y.; Apak, T.I.; Lehmler, H.J.; Robertson, L.W.; Duffel, M.W.Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1Chem. Res. Toxicol.191420-14252006Homo sapiens PubMed
673295He, D.; Falany, C.N.Characterization of proline-serine-rich carboxyl terminus in human sulfotransferase 2B1b: immunogenicity, subcellular localization, kinetic properties, and phosphorylationDrug Metab. Dispos.341749-17552006Homo sapiens PubMed
673311Miyata, M.; Matsuda, Y.; Tsuchiya, H.; Kitada, H.; Akase, T.; Shimada, M.; Nagata, K.; Gonzalez, F.J.; Yamazoe, Y.Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferaseDrug Metab. Pharmacokinet.21315-3232006Mus musculus PubMed
673350Huang, Y.H.; Lee, C.Y.; Tai, P.J.; Yen, C.C.; Liao, C.Y.; Chen, W.J.; Liao, C.J.; Cheng, W.L.; Chen, R.N.; Wu, S.M.; Wang, C.S.; Lin, K.H.Indirect regulation of human dehydroepiandrosterone sulfotransferase family 1A member 2 by thyroid hormonesEndocrinology1472481-24892006Homo sapiens PubMed
673838Seo, Y.K.; Chung, Y.T.; Kim, S.; Echchgadda, I.; Song, C.S.; Chatterjee, B.Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: the role of a gene enhancer in the liver chromatinGene386218-2232007Mus musculus PubMed
674394Chen, X.; Maiti, S.; Zhang, J.; Chen, G.Nuclear receptor interactions in methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1)J. Biochem. Mol. Toxicol.20309-3172006Homo sapiens PubMed
675275Fuda, H.; Javitt, N.B.; Mitamura, K.; Ikegawa, S.; Strott, C.A.Oxysterols are substrates for cholesterol sulfotransferaseJ. Lipid Res.481343-13522007Homo sapiens PubMed
675477Sinclair, P.A.; Gilmore, W.J.; Lin, Z.; Lou, Y.; Squires, E.J.Molecular cloning and regulation of porcine SULT2A1: relationship between SULT2A1 expression and sulfoconjugation of androstenoneJ. Mol. Endocrinol.36301-3112006Sus scrofa PubMed
675998Song, C.S.; Echchgadda, I.; Seo, Y.; Oh, T.; Kim, S.; Kim, S.; Cho, S.; Shi, L.; Chatterjee, B.An essential role of the CAAT/enhancer binding protein-alpha in the vitamin D-induced expression of the human steroid/bile acid-sulfotransferase (SULT2A1)Mol. Endocrinol.2012862006Homo sapiens PubMed
676007Echchgadda, I.; Song, C.S.; Oh, T.; Ahmed, M.; De La Cruz, I.J.; Chatterjee, B.The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferaseMol. Endocrinol.212099-21112007Homo sapiens PubMed
676256Nowell, S.; Falany, C.N.Pharmacogenetics of human cytosolic sulfotransferasesOncogene251673-16782006Homo sapiens PubMed
677143Wang, M.; Ebmeier, C.C.; Olin, J.R.; Anderson, R.J.Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs)Steroids71343-3512006Homo sapiens PubMed
677218Chen, X.; Zhang, J.; Baker, S.M.; Chen, G.Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1)Toxicology231224-2332007Homo sapiens PubMed
677268Miyata, M.; Watase, H.; Hori, W.; Shimada, M.; Nagata, K.; Gonzalez, F.J.; Yamazoe, Y.Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicityXenobiotica36631-6442006Mus musculus PubMed
702138Senggunprai, L.; Yoshinari, K.; Yamazoe, Y.Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferasesBiochem. J.422455-4622009Homo sapiens, Mus musculus PubMed
706919Shimada, M.; Matsuda, T.; Sato, A.; Akase, T.; Matsubara, T.; Nagata, K.; Yamazoe, Y.Expression of a skin cholesterol sulfotransferase, St2b2, is a trigger of epidermal cell differentiationXenobiotica381487-14992008Mus musculus PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 2.8.2.15)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)