Information on EC 2.8.2.11 -

Information on EC 2.8.2.11 - galactosylceramide sulfotransferase:

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EC NUMBER	COMMENTARY
2.8.2.11	-

RECOMMENDED NAME	GeneOntology No.
galactosylceramide sulfotransferase	GO:0001733

REACTION	REACTION DIAGRAM	COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate		-	-	-	-
3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate		the N-glycosylation of Asn-312 and Asn-66 is necessary to form a fully active enzyme	Mus musculus	-	645706

REACTION TYPE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
sulfate group transfer	-	-	-	-
sulfate group transfer	Mus musculus	-	-	702073, 703924
sulfate group transfer	Homo sapiens	-	-	703585

PATHWAY	KEGG Link	MetaCyc Link
No entries in this field

SYSTEMATIC NAME	IUBMB Comments
3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase	Also acts on lactosylceramide.

SYNONYMS	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase	-	-	-	-
cerebroside sulfotransferase	-	-	-	-
cerebroside sulfotransferase	Mus musculus	-	;	672276
cerebroside sulfotransferase	Canis lupus familiaris	-	-	691900, 703917
cerebroside sulfotransferase	Mus musculus	-	-	692514, 702073
cerebroside sulfotransferase	Homo sapiens	-	-	703585
cerebroside sulfotransferase	Chlorocebus sabaeus	-	-	703917
CST	-	-	-	-
CST	Mus musculus	-	;	672276
CST	Canis lupus familiaris	Q9JHE4	-	691900
CST	Mus musculus	-	-	692514, 702073, 703924
CST	Homo sapiens	-	-	703585
galactocerebroside sulfotransferase	-	-	-	-
galactocerebroside sulfotransferase	Mus musculus	-	-	703924
galactolipid sulfotransferase	-	-	-	-
galactosylceramide 3'-sulfotransferase	Homo sapiens	-	-	692513
galactosylceramide sulfotransferase	-	-	-	-
galactosylceramide sulfotransferase	Canis lupus familiaris, Chlorocebus aethiops	-	-	703917
GalCer sulfotransferase	Canis lupus familiaris, Chlorocebus aethiops, Chlorocebus sabaeus	-	-	703917
glycolipid sulfotransferase	-	-	-	-
glycosphingolipid sulfotransferase	-	-	-	-
GSase	-	-	-	-
GST	Canis lupus familiaris, Chlorocebus aethiops, Chlorocebus sabaeus	-	-	703917
sulfotransferase, galactocerebroside	-	-	-	-

CAS REGISTRY NUMBER	COMMENTARY
9081-06-5	-

ORGANISM	COMMENTARY	LITERATURE	SEQUENCE CODE	SEQUENCE DB	SOURCE
Canis lupus familiaris	-	691900	Q9JHE4	UniProt
Canis lupus familiaris	-	703917	-	-
Chlorocebus aethiops	-	703917	-	-
Chlorocebus sabaeus	-	703917	-	-
Homo sapiens	-	645697, 645700, 645701, 645702, 645703, 703585	-	-
Homo sapiens	-	645704, 692513	Q99999	SwissProt
Mus musculus	-	645693, 645699, 645705, 645706, 672276, 702073, 703924	-	-
Mus musculus	-	672276, 692514	Q9JHE4	UniProt
Mycobacterium tuberculosis	-	645707	-	-
Rattus norvegicus	-	645689, 645690, 645691, 645692, 645694, 645695, 645696, 645698	-	-

GENERAL INFORMATION	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
physiological function	Mus musculus	-	CST is involved in sulfatide biosynthesis	702073

SUBSTRATE	PRODUCT	REACTION DIAGRAM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY/ Substrate	LITERATURE/ Substrate	COMMENTARY/ Product	LITERATURE/ Product	Reversibility r=reversible ir=irreversible ?=not specified
3'-phosphoadenylyl sulfate + a galactosylceramide	adenosine 3',5'-bisphosphate + a galactosylceramidesulfate		Mus musculus	-	-	645693	-	-	-
3'-phosphoadenylyl sulfate + a galactosylceramide	adenosine 3',5'-bisphosphate + a galactosylceramidesulfate		Homo sapiens	-	-	692513	-	-	?
3'-phosphoadenylyl sulfate + a galactosylceramide	adenosine 3',5'-bisphosphate + a galactosylceramidesulfate		Mus musculus	Q9JHE4	-	672276	-	-	?
3'-phosphoadenylyl sulfate + a galactosylceramide	adenosine 3',5'-bisphosphate + a galactosylceramidesulfate		Mus musculus	-	-	692514	-	-	?
3'-phosphoadenylyl sulfate + a galactosylceramide	adenosine 3',5'-bisphosphate + a galactosylceramidesulfate		Canis lupus familiaris	Q9JHE4	-	691900	-	-	?
3'-phosphoadenylyl sulfate + a glucosylceramide	adenosine 3',5'-bisphosphate + a glucosylceramidesulfate		Canis lupus familiaris	Q9JHE4	glucosylceramide sulfate accumulates under hypotonic condition	691900	-	-	?
3'-phosphoadenylyl sulfate + galactoscerebroside	adenosine 3',5'-bisphosphate + galactocerebrosidesulfate		Mus musculus	-	galactocerebroside and sulfatide are two major glycolipids in myelin, absence of sulfatide in CST-deficient mice causes axonal disorders	692514	-	-	?
3'-phosphoadenylyl sulfate + galactosylceramide	adenosine 3',5'-bisphosphate + galactosylceramide 3'-sulfate		Homo sapiens	-	-	692513	-	-	?
3'-phosphoadenylyl sulfate + galactosylceramide	adenosine 3',5'-biphosphate + galactosylceramidesulfate		Mus musculus	-	-	703924	-	-	?
galactocerebroside + 3'-phosphoadenylylsulfate	sulfatide + adenosine 3',5'-bisphosphate		Mus musculus	-	-	645693, 645699	-	-	?
galactocerebroside + 3'-phosphoadenylylsulfate	sulfatide + adenosine 3',5'-bisphosphate		Mus musculus	-	-	645706	-	645706	?
galactocerebroside + 3'-phosphoadenylylsulfate	sulfatide + adenosine 3',5'-bisphosphate		Rattus norvegicus	-	-	645689	-	645689	?
galactocerebroside + 3'-phosphoadenylylsulfate	sulfatide + adenosine 3',5'-bisphosphate		Rattus norvegicus	-	-	645691	-	-	?
galactocerebroside + 3'-phosphoadenylylsulfate	sulfogalactoglycerolipid + adenosine 3',5'-bisphosphate		Rattus norvegicus	-	-	645689	-	-	?
galactocerebroside + 3'-phosphoadenylylsulfate	sulfogalactoglycerolipid + adenosine 3',5'-bisphosphate		Rattus norvegicus	-	-	645696	-	645696	?
galactocerebroside + 3'-phosphoadenylylsulfate	sulfogalactoglycerolipid + adenosine 3',5'-bisphosphate		Homo sapiens	Q99999	-	645704	-	-	?
galactocerebroside + 3'-phosphoadenylylsulfate	sulfogalactoglycerolipid + adenosine 3',5'-bisphosphate		Mus musculus	-	enzyme catalyses the biosynthesis of sulfatides, sulfatides are important components of myelin	645706	-	-	-
galactocerebroside + 3'-phosphoadenylylsulfate	sulfogalactoglycerolipid + adenosine 3',5'-bisphosphate		Mus musculus	-	enzyme catalyses the biosynthesis of sulfatides, sulfatides are important components of myelin	645693	-	-	?
galactoglycerolipid + 3'-phosphoadenylylsulfate	sulfogalactoglycerolipid + adenosine 3',5'-bisphosphate		Rattus norvegicus	-	-	645696	-	645696	?
galactosyl 1-alkyl-2-acyl-sn-glycerol + 3'-phosphoadenylylsulfate	galactosyl 1-alkyl-2-acyl-sn-glycerol sulfate + adenosine 3',5'-bisphosphate		Mus musculus	-	-	645706	-	-	-
galactosyl 1-alkyl-2-acyl-sn-glycerol + 3'-phosphoadenylylsulfate	galactosyl 1-alkyl-2-acyl-sn-glycerol sulfate + adenosine 3',5'-bisphosphate		Homo sapiens	-	-	645703	-	-	?
galactosyl diacylglycerol + 3'-phosphoadenylylsulfate	galactosyl diacylglycerol sulfate + adenosine 3',5'-bisphosphate		Homo sapiens	-	-	645703	-	-	?
galactosylceramide + 3'-phosphoadenylylsulfate	galactosylceramide sulfate + adenosine 3',5'-bisphosphate		Homo sapiens	-	-	645700	-	-	?
galactosylceramide + 3'-phosphoadenylylsulfate	galactosylceramide sulfate + adenosine 3',5'-bisphosphate		Homo sapiens	-	-	645701	-	645701	?
galactosylceramide + 3'-phosphoadenylylsulfate	galactosylceramide sulfate + adenosine 3',5'-bisphosphate		Homo sapiens	-	best substrate	645703	-	-	?
galactosylceramide + 3'-phosphoadenylylsulfate	galactosylceramide sulfate + adenosine 3',5'-bisphosphate		Mycobacterium tuberculosis	-	substrates are galactosylceramide type I and II , sulfation may occur at C-3 of the galactose	645707	-	-	?
galactosylceramide + 3'-phosphoadenylylsulfate	galactosylceramide sulfate + adenosine 3',5'-bisphosphate		Mus musculus	-	biotinylated and light-sensitive azido derivatives of lysogalactosylceramide are synthesized by the crude enzyme preparation, these derivatives remain effective substrates for the testicular enzyme	645699	-	-	?
galactosylceramide + 3'-phosphoadenylylsulfate	galactosylceramide sulfate + adenosine 3',5'-bisphosphate		Rattus norvegicus	-	biotinylated and light-sensitive azido derivatives of lysogalactosylceramide are synthesized by the crude enzyme preparation, these derivatives remain effective substrates for the testicular enzyme	645690, 645698	-	-	?
glucosylceramide + 3'-phosphoadenylylsulfate	glucosylceramide sulfate + adenosine 3',5'-bisphosphate		Mycobacterium tuberculosis	-	-	645707	-	-	?
lactosylceramide + 3'-phosphoadenylylsulfate	lactosylceramide sulfate + adenosine 3',5'-bisphosphate		Homo sapiens	-	-	645700	-	-	?
lactosylceramide + 3'-phosphoadenylylsulfate	lactosylceramide sulfate + adenosine 3',5'-bisphosphate		Homo sapiens	-	second best substrate	645703	-	-	?
additional information	?	-	Homo sapiens	Q99999	-	645704	-	-	-
additional information	?	-	Homo sapiens	-	no substrate are globotriaosylceramide, galactose and lactose	645703	-	-	-
additional information	?	-	Mycobacterium tuberculosis	-	no substrate is 3�-sulfate galactosylceramide	645707	-	-	-
additional information	?	-	Rattus norvegicus	-	enzyme is responsible for the synthesis of the major mammalian testicular glycolipid, sulfogalactosylglycerol and is an early marker of differentiation during spermatogenesis	645694, 645696	-	-	-
additional information	?	-	Rattus norvegicus	-	enzyme regulates the sulfation of glycolipids	645698	-	-	-
additional information	?	-	Mycobacterium tuberculosis	-	the enzyme is possibly involved in the biosynthesis of the biologically relevant trehalose sulfolipids of the cell wall	645707	-	-	-
additional information	?	-	Mus musculus	-	enzyme is a key enzyme in the biosynthesis of sulfoglycolipids	645705	-	-	-
additional information	?	-	Mus musculus	Q9JHE4	CST catalyzes the 3'-sulfation of galactose residues in several glycolipids, its major product in the mammalian brain is sulfatide, which is an essential myelin component	672276	-	-	-
additional information	?	-	Mus musculus	-	sulfatide synthesis from galactosylceramides	702073	-	-	-
additional information	?	-	Homo sapiens	-	the final step in synthesis of the glycosphingolipid beta-galactosylceramide-3-O-sulfate is performed by cerebroside sulfotransferase	703585	-	-	-

NATURAL SUBSTRATES	NATURAL PRODUCTS	REACTION DIAGRAM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY SUBSTRATE	LITERATURE (Substrate)	COMMENTARY PRODUCT	LITERATURE (Product)
3'-phosphoadenylyl sulfate + a galactosylceramide	adenosine 3',5'-bisphosphate + a galactosylceramidesulfate		Homo sapiens	-	-	692513	-	-
3'-phosphoadenylyl sulfate + a galactosylceramide	adenosine 3',5'-bisphosphate + a galactosylceramidesulfate		Mus musculus	Q9JHE4	-	672276	-	-
3'-phosphoadenylyl sulfate + a galactosylceramide	adenosine 3',5'-bisphosphate + a galactosylceramidesulfate		Mus musculus	-	-	692514	-	-
3'-phosphoadenylyl sulfate + a galactosylceramide	adenosine 3',5'-bisphosphate + a galactosylceramidesulfate		Canis lupus familiaris	Q9JHE4	-	691900	-	-
3'-phosphoadenylyl sulfate + galactoscerebroside	adenosine 3',5'-bisphosphate + galactocerebrosidesulfate		Mus musculus	-	galactocerebroside and sulfatide are two major glycolipids in myelin, absence of sulfatide in CST-deficient mice causes axonal disorders	692514	-	-
3'-phosphoadenylyl sulfate + galactosylceramide	adenosine 3',5'-bisphosphate + galactosylceramide 3'-sulfate		Homo sapiens	-	-	692513	-	-
galactocerebroside + 3'-phosphoadenylylsulfate	sulfogalactoglycerolipid + adenosine 3',5'-bisphosphate		Rattus norvegicus	-	-	645689	-	-
galactocerebroside + 3'-phosphoadenylylsulfate	sulfogalactoglycerolipid + adenosine 3',5'-bisphosphate		Rattus norvegicus	-	-	645696	-	645696
galactocerebroside + 3'-phosphoadenylylsulfate	sulfogalactoglycerolipid + adenosine 3',5'-bisphosphate		Homo sapiens	Q99999	-	645704	-	-
galactocerebroside + 3'-phosphoadenylylsulfate	sulfogalactoglycerolipid + adenosine 3',5'-bisphosphate		Mus musculus	-	enzyme catalyses the biosynthesis of sulfatides, sulfatides are important components of myelin	645706, 645693	-	-
additional information	?	-	Homo sapiens	Q99999	-	645704	-	-
additional information	?	-	Rattus norvegicus	-	enzyme is responsible for the synthesis of the major mammalian testicular glycolipid, sulfogalactosylglycerol and is an early marker of differentiation during spermatogenesis	645694, 645696	-	-
additional information	?	-	Rattus norvegicus	-	enzyme regulates the sulfation of glycolipids	645698	-	-
additional information	?	-	Mycobacterium tuberculosis	-	the enzyme is possibly involved in the biosynthesis of the biologically relevant trehalose sulfolipids of the cell wall	645707	-	-
additional information	?	-	Mus musculus	-	enzyme is a key enzyme in the biosynthesis of sulfoglycolipids	645705	-	-
additional information	?	-	Mus musculus	Q9JHE4	CST catalyzes the 3'-sulfation of galactose residues in several glycolipids, its major product in the mammalian brain is sulfatide, which is an essential myelin component	672276	-	-
additional information	?	-	Mus musculus	-	sulfatide synthesis from galactosylceramides	702073	-	-
additional information	?	-	Homo sapiens	-	the final step in synthesis of the glycosphingolipid beta-galactosylceramide-3-O-sulfate is performed by cerebroside sulfotransferase	703585	-	-

COFACTOR	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
No entries in this field

METALS and IONS	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
Ca2+	Rattus norvegicus	-	1-10 mM and 20-35 mM: enhancement	645698
KCl	Mus musculus	-	stimulates	645699
Mg2+	Rattus norvegicus	-	1-10 mM: enhances activity, 20-35 mM: inhibition	645698
Mg2+	Mus musculus	-	MgCl2 stimulates	645699
Mn2+	Rattus norvegicus	-	1-10 mM: enhances activity, 20-35 mM: inhibition	645698
Mn2+	Mus musculus	-	MnCl2 stimulates	645699
NaCl	Mus musculus	-	stimulates	645699

INHIBITORS	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
1-amino-4-bromoanthraquinone 2-sulfonic acid	Rattus norvegicus	-	-	645695	2D-image
1-Anilinonaphthalene 8-sulfonic acid	Rattus norvegicus	-	-	645695	2D-image
2,4,5,7-Tetraiodofluorescein	Rattus norvegicus	-	-	645695	2D-image
2-Deoxy-3'-phosphoadenosine 5'-phosphate	Rattus norvegicus	-	-	645698	2D-image
3'-phosphoadenosine 5'-phosphate	Rattus norvegicus	-	-	645698	2D-image
adenosine diphosphopyridoxal	Homo sapiens	-	followed by reduction with NaBH4, addition of adenosine 3�-phosphate 5�-phosphosulfate results in protection against the inactivation	645702	2D-image
ADP	Mus musculus	-	-	645699	2D-image
brefeldin A	Homo sapiens	-	-	645701	2D-image
Cibacron blue F3GA	Rattus norvegicus	-	-	645695	2D-image
Congo red	Rattus norvegicus	-	-	645695	2D-image
Green A	Rattus norvegicus	-	-	645695	2D-image
guanosine 3',5'-diphosphate	Rattus norvegicus	-	-	645698	2D-image
Mg2+	Rattus norvegicus	-	1-10 mM: enhances activity, 20-35 mM: inhibition	645698	2D-image
NaCl	Homo sapiens	-	inhibition at concentration above 0.1 M	645703	2D-image
Orange A	Rattus norvegicus	-	-	645695	2D-image
Procion red	Rattus norvegicus	-	-	645695	2D-image
pyridoxal 5'phosphate	Homo sapiens	-	followed by reduction with NaBH4, irreversible inactivation, addition of adenosine 3�-phosphate 5�-phosphosulfate results in protection against the inactivation	645702	2D-image
Mn2+	Rattus norvegicus	-	1-10 mM: enhances activity, 20-35 mM: inhibition	645698	2D-image
additional information	Rattus norvegicus	-	not: 2'-phosphoadenosine 5'-phosphate, fluorosulfonylbenzoyladenosine	645698	-

ACTIVATING COMPOUND	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
ATP	Mus musculus	-	-	645693	2D-image
ATP	Rattus norvegicus	-	enzyme activity is in vitro dependent on ATP	645696	2D-image
NaCl	Homo sapiens	-	activation at concentration up to 0.1 M	645703	2D-image
Triton X-100	Mus musculus	-	0.4% Triton X-100 is optimal for enzyme activity	645699	2D-image
vitamin K1	Mus musculus	-	with phosphate, activates purified preparation	645693	2D-image
ATP	Mus musculus	-	up to 4 mM stimulates	645699	2D-image
additional information	Rattus norvegicus	-	a testicular protein kinase activity is capable of stimulating the activity in vitro	645694	-
additional information	Homo sapiens	-	purification of an activator protein with MW 22000, glycoprotein, trimer: 3 * 8000, from human liver	645697	-
additional information	Homo sapiens	-	hepatocyte growth factor significantly increases the enzyme activity, 50 ng/ml increases the enzyme activity 2.5fold	645700	-

KM VALUE [mM]	KM VALUE [mM] Maximum	SUBSTRATE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
0.0009	-	3'-phosphoadenylylsulfate	Rattus norvegicus	-	-	645691	2D-image
0.0012	-	3'-phosphoadenylylsulfate	Mus musculus	-	pH 7.0, 37�C	645693	2D-image
0.0052	-	3'-phosphoadenylylsulfate	Rattus norvegicus	-	pH 6.2, 37�C	645698	2D-image
0.025	-	3'-phosphoadenylylsulfate	Homo sapiens	-	pH 6.5, 37�C	645703	2D-image
0.074	-	3'-phosphoadenylylsulfate	Homo sapiens	-	-	645702	2D-image
0.026	-	cerebroside	Mus musculus	-	pH 7.0, 37�C	645693	2D-image
0.002	-	Galactocerebroside	Rattus norvegicus	-	-	645691	2D-image
0.027	-	Galactosylceramide	Homo sapiens	-	pH 6.5, 37�C	645703	2D-image

TURNOVER NUMBER [1/s]	TURNOVER NUMBER MAXIMUM[1/s]	SUBSTRATE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
No entries in this field

kcat/KM VALUE [1/mMs^-1]	kcat/KM VALUE [1/mMs^-1] Maximum	SUBSTRATE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
No entries in this field

Ki VALUE [mM]	Ki VALUE [mM] Maximum	INHIBITOR	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
0.1	-	1-amino-4-bromoanthraquinone 2-sulfonic acid	Rattus norvegicus	-	pH 6.2, 37�C	645695	2D-image
0.54	-	1-Anilinonaphthalene 8-sulfonic acid	Rattus norvegicus	-	pH 6.2, 37�C	645695	2D-image
0.012	-	2,4,5,7-Tetraiodofluorescein	Rattus norvegicus	-	pH 6.2, 37�C	645695	2D-image
0.3	-	3'-phosphoadenosine 5'-phosphate	Rattus norvegicus	-	pH 6.2, 37�C	645698	2D-image
1.17	-	adenosine diphosphopyridoxal	Homo sapiens	-	pH 7.0, 4�C	645702	2D-image
0.021	-	Cibacron blue F3GA	Rattus norvegicus	-	pH 6.2, 37�C, meta isomer	645695	2D-image
0.029	-	Cibacron blue F3GA	Rattus norvegicus	-	pH 6.2, 37�C, para isomer	645695	2D-image
0.041	-	Congo red	Rattus norvegicus	-	pH 6.2, 37�C	645695	2D-image
0.006	-	Green A	Rattus norvegicus	-	pH 6.2, 37�C	645695	2D-image
0.034	-	guanosine 3',5'-diphosphate	Rattus norvegicus	-	pH 6.2, 37�C	645698	2D-image
0.138	-	Orange A	Rattus norvegicus	-	pH 6.2, 37�C	645695	2D-image
0.0012	-	Procion red	Rattus norvegicus	-	pH 6.2, 37�C	645695	2D-image
0.287	-	pyridoxal 5'phosphate	Homo sapiens	-	pH 7.0, 4�C	645702	2D-image

IC50 VALUE [mM]	IC50 VALUE [mM] Maximum	INHIBITOR	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg]	SPECIFIC ACTIVITY MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
1.1e-08	-	Mus musculus	-	crude CST preparation, 44�C, 10 min + 32�C, 60 min	703924
1.6e-08	-	Mus musculus	-	seminiferous tubule, 44�C, 10 min + 32�C, 60 min	703924
2.2e-08	-	Mus musculus	-	crude CST preparation, 37�C, 70 min	703924
6.3e-08	-	Mus musculus	-	crude CST prepared from mouse kidney homogenates, 37�C, 70 min	703924
9.3e-08	-	Mus musculus	-	seminiferous tubule, 37�C, 70 min	703924
1.25e-07	-	Mus musculus	-	crude CST preparation, 32�C, 70 min	703924
2.32e-07	-	Mus musculus	-	crude CST prepared from mouse kidney homogenates, 32�C, 70 min	703924
2.38e-07	-	Mus musculus	-	crude CST prepared from mouse kidney homogenates, untreated	703924
2.5e-07	-	Mus musculus	-	seminiferous tubule, 32�C, 70 min	703924
3.43e-07	-	Mus musculus	-	crude CST preparation, untreated	703924
3.65e-07	-	Mus musculus	-	seminiferous tubule, untreated	703924
1.2	-	Homo sapiens	-	-	645703
additional information	-	Mus musculus	-	-	645693
additional information	-	Rattus norvegicus	-	-	645698
additional information	-	Mus musculus	-	in vitro assay	645699
additional information	-	Homo sapiens	-	-	645700

pH OPTIMUM	pH MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
5.8	6	Rattus norvegicus	-	-	645698
6.5	7	Homo sapiens	-	-	645703
6.5	-	Mus musculus	-	-	645699
6.8	-	Mus musculus	-	activity assay	703924
7	-	Mus musculus	-	-	645693
8	-	Rattus norvegicus	-	-	645696

pH RANGE	pH RANGE MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

TEMPERATURE OPTIMUM	TEMPERATURE OPTIMUM MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
30	-	Mus musculus	-	an optimized assay	645699
32	-	Mus musculus	-	activity assay	703924
37	-	Canis lupus familiaris	-	sulfoglycolipid synthesis is optimal at 37�C	703917

TEMPERATURE RANGE	TEMPERATURE MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

pI VALUE	pI VALUE MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
5.1	-	Rattus norvegicus	-	isoelectric foccusing	645698

SOURCE TISSUE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	SOURCE
brain	Rattus norvegicus	-	-	645689, 645690, 645691, 645692, 645695
brain	Mus musculus	-	-	645693, 645699, 645705, 672276
carcinoma cell	Homo sapiens	-	renal cell carcinoma cell line, SMKT-R3 cells	645700, 645702, 645703, 645704
COS-7 cell	Chlorocebus aethiops, Chlorocebus sabaeus	-	-	703917
gastric mucosa	Homo sapiens	-	reduced expression of the enzyme in the gastric mucosa of chronic gastritis according to the severety of gastric inflammation	692513
kidney	Rattus norvegicus	-	-	645690, 645698
kidney	Mus musculus	-	-	645705, 702073, 703924
kidney	Canis lupus familiaris, Chlorocebus sabaeus	-	-	703917
kidney cell line	Canis lupus familiaris	-	-	703917
liver	Homo sapiens	-	-	645697
liver	Mus musculus	-	-	702073
MDCK cell	Canis lupus familiaris	-	-	691900, 703917
pancreas	Homo sapiens	-	the glycosphingolipid beta-galactosylceramide-3-O-sulfate is present in the secretory granules of the insulin producing beta-cells	703585
Schwann cell	Homo sapiens	-	S16 immortalized Schwann cell line	645701
seminiferous tubule	Mus musculus	-	-	703924
stomach	Homo sapiens	-	from patients with chronic gastritis	692513
testis	Rattus norvegicus	-	-	645690, 645694, 645696
testis	Mus musculus	-	-	645705, 703924

LOCALIZATION	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	GeneOntology No.	LITERATURE	SOURCE
cell surface	Mus musculus	-	minor part of recombinantly expressed enzyme; only a minor fraction of the enzyme	9986	672276
cytosol	Homo sapiens	-	-	5829	645704
Golgi apparatus	Mus musculus	-	but no appearance in the trans-Golgi network; major part of the enzyme, not to the trans-Golgi network	5794	672276
Golgi membrane	Mus musculus	-	major part of the enzyme, the enzyme contains a transmembrane domain	139	672276
plasma membrane	Mus musculus	-	minor part of recombinantly expressed enzyme	5886	672276
microsome	Rattus norvegicus	-	-	-	645689
additional information	Mus musculus	-	determination of subcellular localization, overview	-	672276

PDB	SCOP	CATH	ORGANISM
No entries in this field

MOLECULAR WEIGHT	MOLECULAR WEIGHT MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
28000	-	Mus musculus	-	gel filtration	645693
47000	-	Mus musculus	-	determined by SDS-PAGE and Western Blot analysis	702073
64000	-	Rattus norvegicus	-	nondenaturing PAGE	645698
110000	-	Mus musculus	-	recombinant HA-tagged enzyme, analytical ultracentrifugation	672276

SUBUNITS	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
dimer	Mus musculus	-	2 * 54000, recombinant HA-tagged enzyme, SDS-PAGE, CST forms homodimers, and dimerization is mediated by the lumenal domain of the enzyme, overview	672276
homodimer	Mus musculus	-	calculated, glycerol gradient centrifugation in vitro and fluorescence correlation spectroscopy in vivo	672276
monomer	Mus musculus	-	1 * 31000 SDS-PAGE	645693
monomer	Homo sapiens	-	1 * 54000 SDS-PAGE	645703

POSTTRANSLATIONAL MODIFICATION	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
glycoprotein	Mus musculus	-	two N-glycosylation sites at N66 and N312 are present and used	672276
additional information	Rattus norvegicus	-	enzyme is regulated by a phosphorylatio mechanism	645694, 645696
additional information	Rattus norvegicus	-	purified enzyme contains bound lipids, consisting primarily of cholesterol and phosphatidylcholine, removal of associated lipids results in loss of activity	645698

Crystallization/COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
No entries in this field

pH STABILITY	pH STABILITY MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

TEMPERATURE STABILITY	TEMPERATURE STABILITY MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
37	-	Rattus norvegicus	-	the enzyme in vitro is inactivated at 37�C in the absence of ATP	645696
37	-	Canis lupus familiaris	-	sulfoglycolipid synthesis is low at 40�C, and decreases to 4% at 42�C	703917
45	-	Mus musculus	-	10 min, complete loss of activity	645693
60	-	Rattus norvegicus	-	10 min, complete loss of activity	645698

GENERAL STABILITY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
ethylene glycol, 2-mercaptoethanol, 10 mM ATP and a mixture of phosphatidylcholine and phosphatidylethanolamine ratio 1:1 does not improve stability at -80�C	Mus musculus	-	645693
ATP and Triton X-100 stabilize in vitro	Rattus norvegicus	-	645696

ORGANIC SOLVENT	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
Triton X-100	Mus musculus	-	0.4% Triton X-100 is optimal for enzyme activity	645699

OXIDATION STABILITY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
No entries in this field

STORAGE STABILITY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
-80�C, 20% glycerol, stable for 3 months	Homo sapiens	-	645703
-80�C, 35% loss of activity after 7 days	Mus musculus	-	645693
-80�C, addition of vitamin K + phosphate, stable for 14 days	Mus musculus	-	645693
-20�C, 50% glycerol, 0.1% Triton X-100, pH 7.0-7.5, stable for more than 4 weeks	Rattus norvegicus	-	645698

Purification/COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
-	Homo sapiens	-	645703
-	Mus musculus	-	645693
recombinant enzyme	Mycobacterium tuberculosis	-	645707
-	Rattus norvegicus	-	645691, 645692, 645698

Cloned/COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
when the cDNA is introduced into a eukaryotic expression vector and transfected into COS-1 cells, the enzyme activity expressed exceeds that in controls by 8-16fold	Homo sapiens	-	645704
expression in CHO-GalT cells or COS cells, enzyme can be expressed in a soluble form, that is active both in vitro and in vivo	Mus musculus	-	645706
transcripts of the enzyme gene are detected in kidney, brain, testis, small intestine, stomach, liver, and lung, but the enzyme activity does not correlate with the amount of enzyme mRNA	Mus musculus	-	645705
transient or stable expression as GFP-tagged enzyme in CHO-K1 cells, expression of CST fused to a HA-tag or EGFP in BHK cells; transient or stable expression of pEGFP-CST in CHO-K1 cell	Mus musculus	-	672276
gene Rv1373 is cloned, expressed in Escherichia coli as a recombinant histidine-fusion protein	Mycobacterium tuberculosis	-	645707

EXPRESSION	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
after 24 h under a 42�C heat stress, GST mRNA increased to 174%; cell culture under 42�C heat stress for 24 h, increase of gene expression to 174%	Canis lupus familiaris	-	703917
cell culture under 42�C heat stress for 17 h, increase of gene expression to 148%	Chlorocebus aethiops	-	703917
after 17 h under a 42�C heat stress, GST mRNA increased to 148%	Chlorocebus sabaeus	-	703917
altered expression via protein-overload treatment, protein and gene expression of CST is significantly decreased in the liver in a time-dependent manner	Mus musculus	-	702073
the activity of galactocerebroside sulfotransferase decreases in a temperature-dependent manner	Mus musculus	-	703924
altered expression via protein-overload treatment, renal expression of CST is markedly increased	Mus musculus	-	702073

ENGINEERING	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
rs2267161	Homo sapiens	-	single nucleotide polymorphism located in an exon in the gene encoding CST, heterozygosity confers increased risk of type 2 diabetes	703585
rs42929	Homo sapiens	-	single nucleotide polymorphism located in an intron in the gene encoding CST	703585
N312Q	Mus musculus	-	no activity in comparison to the wild type enzyme in vitro	645706
N66Q	Mus musculus	-	50% loss of activity in comparison to the wild type enzyme in vitro	645706
N66Q/N312Q	Mus musculus	-	no activity in comparison to the wild type enzyme in vitro	645706

Renatured/COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
No entries in this field

APPLICATION	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
medicine	Homo sapiens	-	heterozygosity at SNP rs2267161 in the gene encoding cerebroside sulfotransferase confers increased risk of type 2 diabetes, females with the CC allele show lower insulin resistance	703585
diagnostics	Mus musculus	-	the newly developed system could provide useful basic data for the further analysis of seminolipid metabolism	703924
medicine	Mus musculus	-	inhibition of CST could be an option for the treatment of metachromatic leukodystrophy	672276
medicine	Mus musculus	-	the mechanism, indicating the crosstalk between kidney injury and specific liver functions, may prove useful to understand the situation where human hemodialysis patients have low levels of serum sulfatides	702073

DISEASE	TITLE OF PUBLICATION	LINK TO PUBMED
Acute Kidney Injury	Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides.	PubMed
Adenocarcinoma	Cerebroside sulfotransferase activity in human lung tissues. An elevated level in lung adenocarcinoma.	PubMed
Adenocarcinoma	Detection of cerebroside sulfotransferase mRNA in human gastric mucosa and adenocarcinoma.	PubMed
Carcinoma	Cancer-associated expression of glycolipid sulfotransferase gene in human renal cell carcinoma cells.	PubMed
Carcinoma	Cerebroside sulfotransferase activity in human lung tissues. An elevated level in lung adenocarcinoma.	PubMed
Carcinoma	Involvement of protein kinase C in the regulation of glycolipid sulfotransferase activity levels in renal cell carcinoma cells.	PubMed
Carcinoma	Involvement of Ras in the expression of glycolipid sulfotransferase in human renal cancer cells.	PubMed
Carcinoma	Regulation of activity levels of glycolipid sulfotransferases by transforming growth factor alpha in renal cell carcinoma cells.	PubMed
Carcinoma	Sialylation and sulfation of lactosylceramide distinctly regulate anchorage-independent growth, apoptosis, and gene expression in 3LL Lewis lung carcinoma cells.	PubMed
Carcinoma	Sulfolipids and glycolipid sulfotransferase activities in human renal cell carcinoma cells.	PubMed
Carcinoma	Suppression of integrin expression and tumorigenicity by sulfation of lactosylceramide in 3LL Lewis lung carcinoma cells.	PubMed
Carcinoma	[Studies on the regulation of glycolipid sulfotransferase activity in human renal cancer cells]	PubMed
Carcinoma, Hepatocellular	Elevated serum level of glycolipid sulfotransferase in patients with hepatocellular carcinoma.	PubMed
Carcinoma, Hepatocellular	Inconsistent expression of glycolipid sulfotransferase activity between hepatoma and serum.	PubMed
Carcinoma, Lewis Lung	Sialylation and sulfation of lactosylceramide distinctly regulate anchorage-independent growth, apoptosis, and gene expression in 3LL Lewis lung carcinoma cells.	PubMed
Carcinoma, Lewis Lung	Suppression of integrin expression and tumorigenicity by sulfation of lactosylceramide in 3LL Lewis lung carcinoma cells.	PubMed
Carcinoma, Renal Cell	Cancer-associated expression of glycolipid sulfotransferase gene in human renal cell carcinoma cells.	PubMed
Carcinoma, Renal Cell	Involvement of protein kinase C in the regulation of glycolipid sulfotransferase activity levels in renal cell carcinoma cells.	PubMed
Carcinoma, Renal Cell	Involvement of Ras in the expression of glycolipid sulfotransferase in human renal cancer cells.	PubMed
Carcinoma, Renal Cell	Regulation of activity levels of glycolipid sulfotransferases by transforming growth factor alpha in renal cell carcinoma cells.	PubMed
Carcinoma, Renal Cell	Sulfolipids and glycolipid sulfotransferase activities in human renal cell carcinoma cells.	PubMed
Carcinoma, Renal Cell	[Studies on the regulation of glycolipid sulfotransferase activity in human renal cancer cells]	PubMed
Dementia	Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis.	PubMed
Endometrial Neoplasms	Expression of GalCer sulfotransferase by human uterine endometrial carcinoma cell lines.	PubMed
galactosylceramide sulfotransferase deficiency	Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction.	PubMed
Gastritis	Reduced expression of sulfatides and galactosylceramide 3'-sulfotransferase in the gastric mucosa of chronic gastritis.	PubMed
Glioblastoma	Effect of glucocorticoids on galactosylceramide sulfotransferase activity in rat brain.	PubMed
Glioblastoma	Influence of reduced cholesterol synthesis on the activity of cerebroside sulfotransferase in cultured glioblastoma cells treated with estradiol.	PubMed
Glycogen Storage Disease	Surprises of genetic engineering: a possible model of polyglucosan body disease.	PubMed
Infection	Ultrastructural and biochemical findings in brain cell cultures infected with canine distemper virus.	PubMed
Insulin Resistance	A variation in the cerebroside sulfotransferase gene is linked to exercise-modified insulin resistance and to type 2 diabetes.	PubMed
Kidney Neoplasms	Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene.	PubMed
Kidney Neoplasms	Involvement of Ras in the expression of glycolipid sulfotransferase in human renal cancer cells.	PubMed
Kidney Neoplasms	Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells.	PubMed
Kidney Neoplasms	Pyridoxal 5'-phosphate binds to a lysine residue in the adenosine 3'-phosphate 5'-phosphosulfate recognition site of glycolipid sulfotransferase from human renal cancer cells.	PubMed
Kidney Neoplasms	Regulation of glycolipid sulfotransferase by tyrosine kinases in human renal cancer cells.	PubMed
Kidney Neoplasms	[Studies on the regulation of glycolipid sulfotransferase activity in human renal cancer cells]	PubMed
Lafora Disease	Surprises of genetic engineering: a possible model of polyglucosan body disease.	PubMed
Melanoma	Inhibitory effects of N-(4-hydrophenyl) retinamide on liver cancer and malignant melanoma cells.	PubMed
Neoplasms	Expression of GalCer sulfotransferase by human uterine endometrial carcinoma cell lines.	PubMed
Neoplasms	Inconsistent expression of glycolipid sulfotransferase activity between hepatoma and serum.	PubMed
Neoplasms	Presence and characterization of glycolipid sulfotransferase in human cancer serum.	PubMed
Neoplasms	Regulation of renal sulfoglycolipid biosynthesis.	PubMed
Neoplasms	[Characterization of glycolipid sulfotransferase fractionated from rat kidney and involvement of the enzyme in human cancer]	PubMed
Neoplasms	[Glycolipid sulfotransferase and cancer]	PubMed
Neoplasms	[Glycosphingolipids in human uterine endometrium: expression of sulfoglycolipids and its fluctuation during menstrual cycle]	PubMed
Neuroblastoma	[Sulfurtransferase activity in cultured neuronal clone cells]	PubMed
Tuberculosis	Molecular cloning and expression of a novel glycolipid sulfotransferase in Mycobacterium tuberculosis.	PubMed
Ureteral Obstruction	Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction.	PubMed

REF.	AUTHORS	TITLE	JOURNAL	VOL.	PAGES	YEAR	ORGANISM	LINK TO PUBMED	SOURCE
645689	McKhann, G.M.; Levy, R.; Ho, W.	Metabolism of sulfatides. I. The effect of galactocerebrosides on the synthesis of sulfatides	Biochem. Biophys. Res. Commun.	20	109-113	1965	Rattus norvegicus	PubMed
645690	Lingwood, C.; Taylor, T.	Synthesis and use of galactolipid sulfotransferase substrate-analogue affinity probes: possible localization of the testicular enzyme	Biochem. Cell Biol.	64	631-637	1986	Rattus norvegicus	PubMed
645691	Tennekoon, G.; McKhann, G.M.	Galactocerebroside sulfotransferase: further characterization of the enzyme from rat brain	J. Neurochem.	31	329-339	1978	Rattus norvegicus	PubMed
645692	Sarlieve, L.L.; Neskovic, N.M.; Rebel, G.; Mandel, P.	Solubilization and partial purification of 3-phosphoadenosine-5-phosphosulphate: galactocerebroside sulphotransferase from rat brain	J. Neurochem.	26	211-215	1976	Rattus norvegicus	PubMed
645693	Sundaram, K.S.; Lev, M.	Purification and activation of brain sulfotransferase	J. Biol. Chem.	267	24041-24044	1992	Mus musculus	PubMed
645694	Sakac, D.; Lingwood, C.A.	Modulation of testicular galactolipid sulphotransferase activity by phosphorylation. Stimulation of enzyme activity in vitro by an endogenous kinase	Biochem. J.	261	423-429	1989	Rattus norvegicus	PubMed
645695	Zaruba, M.; Hilt, D.; Tennekoon, G.	Inhibition of rat brain galactocerebroside sulfotransferase by triazine aromatic dyes: interaction with the 3-phosphoadenosine 5-phosphosulfate binding site	Biochem. Biophys. Res. Commun.	129	522-529	1985	Rattus norvegicus	PubMed
645696	Taylor, T.; Oda, K.; Lingwood, C.	Modulation of testicular galactolipid sulfotransferase activity in vitro by ATP	Biochim. Biophys. Acta	913	131-137	1987	Rattus norvegicus	PubMed
645697	Mitsuyama, T.; Gasa, S.; Nojima, T.; Taniguchi, N.; Makita, A.	Purification and properties of galactosylceramide sulfatase activator from human liver	J. Biochem.	98	605-613	1985	Homo sapiens	PubMed
645698	Tennekoon, G.; Aitchinson, S.; Zabura, M.	Purification and characterization of galactocerebroside sulfotransferase from rat kidney	Arch. Biochem. Biophys.	240	932-944	1985	Rattus norvegicus	PubMed
645699	Burkart, T.; Siegrist, H.P.; Herschkowitz, N.N.; Wiesmann, U.N.	3-phosphoadenylylsulfate:galactosylceramide 3-sulfotransferase. An optimized assay in homogenates of developing brain	Biochim. Biophys. Acta	483	303-311	1977	Mus musculus	PubMed
645700	Kobayashi, T.; Honke, K.; Gasa, S.; Miyazaki, T.; Tajima, H.; Matsumoto, K.; Nakamura, T.; Makita, A.	Hepatocyte growth factor elevates the activity levels of glycolipid sulfotransferases in renal cell carcinoma cells	Eur. J. Biochem.	219	407-413	1994	Homo sapiens	PubMed
645701	Farrer, R.G.; Warden, M.P.; Quarles, R.H.	Effects of brefeldin A on galactosphingolipid synthesis in an immortalized Schwann cell line: evidence for different intracellular locations of galactosylceramide sulfotransferase and ceramide galactosyltransferase activities	J. Neurochem.	65	1865-1873	1995	Homo sapiens	PubMed
645702	Kamio, K.; Honke, K.; Makita, A.	Pyridoxal 5'-phosphate binds to a lysine residue in the adenosine 3'-phosphate 5'-phosphosulfate recognition site of glycolipid sulfotransferase from human renal cancer cells	Glycoconjugate J.	12	762-766	1995	Homo sapiens	PubMed
645703	Honke, K.; Yamane, M.; Ishii, A.; Kobayashi, T.; Makita, A.	Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells	J. Biochem.	119	421-427	1996	Homo sapiens	PubMed
645704	Honke, K.; Tsuda, M.; Hirahara, Y.; Ishii, A.; Makita, A.; Wada, Y.	Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase	J. Biol. Chem.	272	4864-4868	1997	Homo sapiens	PubMed
645705	Hirahara, Y.; Tsuda, M.; Wada, Y.; Honke, K.	cDNA cloning, genomic cloning, and tissue-specific regulation of mouse cerebroside sulfotransferase	Eur. J. Biochem.	267	1909-1917	2000	Mus musculus	PubMed
645706	Eckhardt, M.; Fewou, S.N.; Ackermann, I.; Gieselmann, V.	N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase	Biochem. J.	368	317-324	2002	Mus musculus	PubMed
645707	Rivera-Marrero, C.A.; Ritzenthaler, J.D.; Newburn, S.A.; Roman, J.; Cummings, R.D.	Molecular cloning and expression of a novel glycolipid sulfotransferase in Mycobacterium tuberculosis	Microbiology	148	783-792	2002	Mycobacterium tuberculosis	PubMed
672276	Yaghootfam, A.; Sorkalla, T.; Haeberlein, H.; Gieselmann, V.; Kappler, J.; Eckhardt, M.	Cerebroside sulfotransferase forms homodimers in living cells	Biochemistry	46	9260-9269	2007	Mus musculus	PubMed
691900	Niimura, Y.; Nagai, K.	Metabolic responses of sulfatide and related glycolipids in Madin-Darby canine kidney (MDCK) cells under osmotic stresses	Comp. Biochem. Physiol. B	149	161-167	2008	Canis lupus familiaris	PubMed
692513	Hayashi, A.; Nakashima, K.; Yamagishi, K.; Hoshi, T.; Suzuki, A.; Baba, H.	Localization of annexin II in the paranodal regions and Schmidt-Lanterman incisures in the peripheral nervous system	Glia	55	1044-1052	2007	Homo sapiens	PubMed
692514	Hoshi, T.; Suzuki, A.; Hayashi, S.; Tohyama, K.; Hayashi, A.; Yamaguchi, Y.; Takeuchi, K.; Baba, H.	Nodal protrusions, increased Schmidt-Lanterman incisures, and paranodal disorganization are characteristic features of sulfatide-deficient peripheral nerves	Glia	55	584-594	2007	Mus musculus	PubMed
702073	Zhang, X.; Nakajima, T.; Kamijo, Y.; Li, G.; Hu, R.; Kannagi, R.; Kyogashima, M.; Aoyama, T.; Hara, A.	Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides	Biochem. Biophys. Res. Commun.	390	1382-1388	2009	Mus musculus	PubMed
703585	Roeske-Nielsen, A.; Buschard, K.; Manson, J.; Rastam, L.; Lindblad, U.	A variation in the cerebroside sulfotransferase gene is linked to exercise-modified insulin resistance and to type 2 diabetes	Exp. Diabetes Res.	FEHLT	0000	2009	Homo sapiens	PubMed
703917	Niimura, Y.; Moue, T.; Takahashi, N.; Nagai, K.I.	Modification of sphingoglycolipids and sulfolipids in kidney cell lines under heat stress: Activation of monohexosylceramide synthesis as a ceramide scavenger	Glycobiology	20	710-717	2010	Canis lupus familiaris, Chlorocebus aethiops, Chlorocebus sabaeus	PubMed
703924	Nagai, K.I.; Tadano-Aritomi, K.; Niimura, Y.; Ishizuka, I.	Development and application of a system for seminolipid metabolism using mouse seminiferous tubules	Glycoconj. J.	27	181-187	2010	Mus musculus	PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 2.8.2.11)

NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM

IUBMB Enzyme Nomenclature

PROSITE Database of protein families and domains

SYSTERS

Protein Mutant Database

InterPro (database of protein families, domains and functional sites)

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