| SUBSTRATE | PRODUCT | REACTION DIAGRAM | ORGANISM | UNIPROT ACCESSION NO. | COMMENTARY/
Substrate | LITERATURE/
Substrate | COMMENTARY/
Product | LITERATURE/
Product | Reversibility
r=reversible
ir=irreversible
?=not specified |
| ATP + 3-hydroxy-3-methylglutaryl-CoA reductase | ADP + phosphorylated 3-hydroxy-3-methylglutaryl-CoA reductase |
 | Rattus norvegicus | - | - | 491418 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Mus musculus | - | - | 660953 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Sulfolobus solfataricus | - | - | 680439, 680441, 680448 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Schizosaccharomyces pombe | O13839, O59790, O74135, O74536, O94751, P07334, P08092, P34208, P36616, P38938, P40231, P40233, P40234, P40235, P40236, P50526, P50527, P50582, P87050, Q07538, Q09170, Q10056, Q10292, Q9UQY9 | - | 491211 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Schizosaccharomyces pombe | - | - | 532744 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | P22211 | - | 532746 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | P25333 | - | 532747 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | - | 532748 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | P36002 | - | 532749 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | P47116 | - | 532750 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | P23291, P23292, P32361, P38691, Q03497 | - | 490973 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | - | 532751, 532753, 532755 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | P29295, Q12505 | - | 491607 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | - | 532757 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Orgyia pseudotsugata MNPV | O10269 | - | 532786 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Autographa californica nucleopolyhedrovirus | P41415 | - | 532787 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Autographa californica nucleopolyhedrovirus | - | - | 532788, 532789 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Heliothis zea nuclear polyhedrosis virus | P41719 | - | 532790 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Lymantria dispar MNPV | P41720 | - | 532791 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Mus musculus | Q99mw1 | - | 532798 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Homo sapiens | Q9BXU1 | - | 532798 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | autophosphorylation | 532769 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | P53323 | autophosphorylation | 532792 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Rattus norvegicus | Q62761, Q62762, Q62763 | autophosphorylation when incubated with ATP and Mg2+ | 491630 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Plasmodium falciparum | O15726 | strong preference for ATP over GTP | 491593 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Myxococcus xanthus | P54737, P54738 | Pkn5 is autophosphorylated only at Ser | 532719 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Streptomyces coelicolor | - | self-catalyzed phosphate incorporation into both Ser and Tyr residues of AfsK | 532722 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Myxococcus xanthus | P54737, P54738 | Pkn6 is autophosphorylated both at Ser and Thr | 532719 | - | - | - |
| ATP + a protein | ADP + a phosphoprotein |
| Mycobacterium tuberculosis | - | autophosphorylation on Thr | 532698 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Vaccinia virus | - | the enzyme is essential for viral replication | 491600 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Schizosaccharomyces pombe | - | not essential for cell viability, Cki2, may contribute to the regulation of cell morphology | 491613 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | the enzyme is a regulator of DNA strand-break repair | 491608 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Schizosaccharomyces pombe | - | enzyme is involved in the regulation of DNA repair | 491615 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | enzyme plays a pivotal role in eukaryotic cell regulation | 491605 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Schizosaccharomyces pombe | - | gene disruption reveales that cki3+ is dispensable for cell viability, and cells lacking functional cki3+ exhibit no characteristic phenotype | 491594 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Drosophila melanogaster | - | casein kinase 1 alpha gene is developmentally regulated and the kinase activity of the protein is induced by DNA damage. Possible requirement in mechanisms associated with DNA repair during early embryogenesis | 491624 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Myxococcus xanthus | P54737, P54738 | Pkn5 negatively regulates Myxococcus xanthus development | 532719 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Streptomyces coelicolor | - | AfsK plays a regulatory role in aerial mycelium formation in Streptomyces griseus | 532723 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Myxococcus xanthus | P54737, P54738 | expressed constitutively throughout the life cycle, with slight increases at an early stage of development | 532719 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Myxococcus xanthus | P54736 | the enzyme blocks the secretion of beta-lactamase by phosphorylation | 532718 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Anabaena sp. | - | pknA is required for both normal cellular growth and differentiation | 532717 | - | - | - |
| ATP + a protein | ADP + a phosphoprotein |
| Myxococcus xanthus | P54737, P54738 | Pkn6 may be a transmembrane sensor of external signals for development | 532719 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Streptomyces coelicolor | - | involvement of afsK in the regulation of secondary metabolism | 532722 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | P22211 | the enzyme is required to promote the activity of at least six distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression | 532746 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Schizosaccharomyces pombe | - | the enzyme is a negative regulator of both sexual conjugation and meiosis | 532744 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | P47116 | STK1 mostly affects a lower-affinity, low-capacity polyamine transport activity | 532750 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | enzyme is not essential for vegetative growth | 532751 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | the SKS1 protein kinase is a multicopy suppressor of the snf3 mutation of Saccharomyces cerevisiae | 532757 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | the enzyme enhances spermine uptake in Saccharomyces cerevisiae | 532755 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Homo sapiens | - | in some cancers displaying chromosomal instability the loss of this checkpoint is associated with the mutational inactivation of a human homologue of the yeast BUB1 gene | 532763 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Schizosaccharomyces pombe | - | the enzyme is essential for the fission yeast spindle checkpoint response to spindle damage and to defects in centromere function. Activation of the checkpoint results in the recruitment of Bub1 to centromeres and a delay in the completion of mitosis. Bub1 also has a crucial role in normal, unperturbed mitoses. Loss of bub1 function causes chromosomes to lag on the anaphase spindle and an increased frequency of chromosome loss. bub1(+)function is essential to maintain correct ploidy through mitosis | 532767 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Mus musculus | - | the enzyme is required for function of the spindle assembly checkpoint | 532759 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Homo sapiens | O43683 | the enzyme is required for function of the spindle assembly checkpoint | 532759 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Homo sapiens | - | cell cycle-dependent expression, Bub1b has a putative destruction box that can target proteins for degradation by proteosomes during mitosis | 532764 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Mus musculus | Q9Z1S0 | cell cycle-dependent expression, Bub1b has a putative destruction box that can target proteins for degradation by proteosomes during mitosis | 532764 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | P41695 | the enzyme is involved in spindle assembly during the cell cycle | 532768 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Homo sapiens | - | hBUBR1 may regulate multiple functions that include the kinetochore and the spindle midzone | 532765 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Mus musculus | O08901 | kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage | 532758 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Homo sapiens | - | hBub1 is an important component of the spindle checkpoint pathway. hBub1 expression is restricted to proliferating cells and appears to be involved in regulating cell cycle progression | 532762 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Homo sapiens | - | Bub1 is required for binding Bub3 | 532761 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Homo sapiens | - | huCdc7 may regulate processes of DNA replication by modulating MCM functions | 532777 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Homo sapiens | - | HsCdc7 may phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication | 532776 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | the enzyme is required for the initiation of mitotic DNA synthesis. It is necessary for genetic recombination during meiosis and for the formation of ascospores, involved in an error-prone DNA repair pathway | 532781 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Schizosaccharomyces pombe | - | the enzyme is required for inhibition of mitosis until completion of S phase, it may also be involved in proper execution of mitosis | 532782 | - | - | - |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | enzyme is required for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis | 532779 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Schizosaccharomyces pombe | - | the enzyme is dispensable for mitotic growth and premeiotic DNA replication, its primary role is in meiosis | 532784 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | P53323 | the enzyme is essential for normal cell life | 532792 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | the enzyme is required for inositol phototrophy in Saccharomyces cerevisiae | 532802 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | Ire1p is required for activation of the unfolded protein response. It senses the accumulation of unfolded proteins in the ER and transmits the signal across the membrane toward the transcription machinery, possibly by phosphorylating downstream components of the UPR pathway | 532799 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Saccharomyces cerevisiae | - | the enzyme is required for signaling from the ER to the nucleus | 532801 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Sulfolobus solfataricus | - | phosphorylation of exogenous substrates takes place on serine and, occasionally, threonine, but the enzyme displays a strong preference for threonine as the phospho-acceptor amino acid residue, overview, no activity with GTP except for the autophosphorylation reaction in vitro which functions with GTP and also GDP | 680448 | - | - | ? |
| ATP + a protein | ADP + a phosphoprotein |
| Sulfolobus solfataricus | - | PK2 phosphorylate itself as well as several exogenous proteins, including mixed histones, casein, bovine serum albumin, and reduced carboxyamidomethylated and maleylated lysozyme, on serine residues, overview, autophosphorylation of rSsoPK2 can be uncoupled from the phosphorylation of exogenous proteins by manipulation of the temperature or mutagenic alteration of the enzyme, autophosphorylation is detected only at temperatures above 60°C, whereas phosphorylation of exogenous proteins is detectable at 37°C | 680441 | - | - | ? |
| ATP + AaSTPK | ADP + phosphorylated-AaSTPK |
| Aquifex aeolicus | O66844 | enzyme is autophosphorylated on a threonine residue | 694132 | - | - | ? |
| ATP + ABCA1 NBD1-R1 protein | ADP + phosphorylated ABCA1 NBD1-R1 protein |
| Homo sapiens | - | substrate protein is a recombinant construct of wild-type and mutant nucleotide binding domain 1 and cytoplasmic domain R1 of ATP-binding cassette transporter protein A1 expressed in Escherichia coli, phosphorylation at T1242, T1243, and S1255 | 662260 | - | - | ? |
| ATP + ABCA1 NBD2-R2 protein | ADP + phosphorylated ABCA1 NBD2-R2 protein |
| Homo sapiens | - | substrate protein is a recombinant construct of wild-type and mutant nucleotide binding domain 2 and cytoplasmic domain R2 of ATP-binding cassette transporter protein A1 expressed in Escherichia coli | 662260 | - | - | ? |
| ATP + Ac-LRRASLG | ADP + Ac-LRRApSLG |
| Bos taurus | - | an efficient fluorescence assay for serine/threonine kinases using a peptide array is developed. Assay is based on chemical reactions specific to phosphoserine and phosphothreonine residues, that is, base-mediated beta-elimination of the phosphate group and subsequent Michael addition of a thiol-containing fluorescent reagent. This procedure enables the covalent introduction of a fluorescent moiety into the phosphorylated peptide. Novel fluorescent reagents are designed for this purpose and synthesized. As a model peptide, a well-known PKA consensus sequence Kemptide 49 is chosen | 691233 | - | - | ? |
| ATP + Ac-RPRAASF | ADP + Ac-Ac-RPRAApSF |
| Homo sapiens | - | an efficient fluorescence assay for serine/threonine kinases using a peptide array is developed. Assay is based on chemical reactions specific to phosphoserine and phosphothreonine residues, that is, base-mediated beta-elimination of the phosphate group and subsequent Michael addition of a thiol-containing fluorescent reagent. This procedure enables the covalent introduction of a fluorescent moiety into the phosphorylated peptide. Novel fluorescent reagents are designed for this purpose and synthesized | 691233 | - | - | ? |
| ATP + acetyl-CoA carboxylase | ADP + phosphorylated acetyl-CoA carboxylase |
| Rattus norvegicus | - | - | 491418 | - | - | ? |
| ATP + acetyl-CoA carboxylase | ADP + phosphorylated acetyl-CoA carboxylase |
| Homo sapiens | - | phosphorylation and inactivation | 491406 | - | - | ? |
| ATP + adenomatous polyposis coli protein | ADP + phosphorylated adenomatous polyposis coli protein |
| Drosophila melanogaster, Homo sapiens, Xenopus laevis | - | i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon | 673856 | - | - | ? |
| ATP + adenylosuccinate synthase | ADP + phosphorylated adenylosuccinate synthase |
| Staphylococcus aureus | - | PknB specifically phosphorylates adenylosuccinate synthase, phosphorylated adenylosuccinate synthase shows a 1.8fold decrease in enzymatic activity compared to unphosphorylated enzyme | 708924 | - | - | ? |
| ATP + AfsR | ADP + ? |
| Streptomyces coelicolor | - | phosphorylation at both Ser and Thr residues | 532722 | - | - | ? |
| ATP + AfsR protein | ADP + AfsR phosphoprotein |
| Streptomyces coelicolor | - | kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview, phosphorylation of serine and threonine residues by activated kinase AfsK, and by PkaG and SCD10.09, the Streptomyces coelicolor strain A3(2) contains more than 40 enzymes phosphorylating the substrate AsfR | 662578 | - | - | ? |
| ATP + Akt | ADP + phosphorylated Akt |
| Rattus norvegicus | - | CK2 phosphorylates and activates Akt directly, CK2 phosphorylates and activates Akt directly, phosphorylation at Ser473 | 675550 | - | - | ? |
| ATP + Akt (MBP) | ADP + phosphorylated-Akt |
| Rattus norvegicus | - | purified Pak1 can directly phosphorylate Akt only at Ser473, suggesting that Pak1 may be a relevant PDK2 responsible for AKT Ser473 phosphorylation in cardiomyocytes | 693696 | - | - | ? |
| ATP + alpha-casein | ADP + phosphorylated alpha-casein |
| Homo sapiens | - | casein kinase 1alpha | 662912 | - | - | ? |
| ATP + alpha-casein | ADP + phosphorylated alpha-casein |
| Archaeoglobus fulgidus | O30245 | dephosphorylated alpha-casein | 663404 | - | - | ? |
| ATP + apoptosis signal-regulating kinase 1 | ADP + phosphorylated-apoptosis signal-regulating kinase 1 |
| Mus musculus | Q61846 | MPK28 stimulates APK1 activity by Thr838 phosphorylation | 693189 | - | - | ? |
| ATP + axin | ADP + phosphorylated axin |
| Homo sapiens | - | glycogen synthase kinase 3 | 660951 | - | - | ? |
| ATP + BAF155 | ADP + phosphorylated BAF155 |
| Homo sapiens | - | BAF155 is a hSWI/SNF protein that contains three Akt consensus sites, phosphorylation site analysis using recombinant full-length and truncated substrate versions, overview | 676261 | - | - | ? |
| ATP + BAF170 | ADP + phosphorylated BAF170 |
| Homo sapiens | - | BAF170 is a hSWI/SNF protein that contains one Akt consensus site | 676261 | - | - | ? |
| ATP + beta-catenin | ADP + phosphorylated beta-catenin |
| Homo sapiens | - | glycogen synthase kinase 3 | 660951 | - | - | ? |
| ATP + beta-catenin | ADP + phosphorylated beta-catenin |
| Drosophila melanogaster, Homo sapiens, Xenopus laevis | - | phosphorylation at Ser45, priming GSK3beta phosphorylation | 673856 | - | - | ? |
| ATP + beta-hydroxy beta-methylglutaryl-coenzyme A reductase | ADP + phosphorylated beta-hydroxy beta-methylglutaryl-coenzyme A reductase |
| Homo sapiens | - | phosphorylation and inactivation | 491406 | - | - | ? |
| ATP + bovine serum albumin | ? |
| Saccharomyces cerevisiae | - | not | 645084 | - | - | - |
| ATP + bovine serum albumin | ? |
| Bos taurus | - | mitochondrial protamine kinases, not cytosolic kinase | 645089 | - | - | ? |
| ATP + bovine serum albumin | ? |
| Bos taurus | - | phosphorylated at 40-70% the rate of protamine | 645086 | - | - | ? |
| ATP + bovine serum albumin | ? |
| Bos taurus | - | phosphorylated at 48% the rate of protamine | 645089 | - | - | ? |
| ATP + bovine serum albumin | ADP + phosphorylated bovine serum albumin |
| Sulfolobus solfataricus | - | - | 680441, 680448 | - | - | ? |
| ATP + Bub3 | ADP + phosphorylated Bub3 |
| Saccharomyces cerevisiae | - | - | 532769 | - | - | ? |
| ATP + c-Jun | ADP + phosphorylated c-Jun |
| Mus musculus | - | - | 709940 | - | - | ? |
| ATP + C/EBPalpha | ADP + phosphorylated C/EBPalpha |
| Rattus norvegicus | - | phosphorylation at consensus sequence (S/T)XXX(S/T) with X representing any amino acid | 662407 | - | - | ? |
| ATP + C/EBPbeta | ADP + phosphorylated C/EBPbeta |
| Rattus norvegicus | - | phosphorylation at multiple sites, preferably at Thr189 and Ser185, reduced activity with mutants T189A and S185A, mutation of either site appears to impair phosphorylation of neighbouring sites | 662407 | - | - | ? |
| ATP + casein | ? |
| Saccharomyces cerevisiae | - | not | 645084 | - | - | - |
| ATP + casein | ? |
| Oncorhynchus mykiss | - | poor substrate | 645095 | - | - | ? |
| ATP + casein | ? |
| Bos taurus | - | not mitochondrial protamine kinases, phosphorylated at 5% the rate of protamine, cytosolic kinase | 645089 | - | - | ? |
| ATP + casein | ? |
| Bos taurus | - | phosphorylated at 5% the rate of protamine, cytosolic kinase | 645090 | - | - | ? |
| ATP + casein | ADP + phosphocasein |
| Sulfolobus solfataricus | - | - | 680441, 680448 | - | - | ? |
| ATP + casein | ADP + phosphorylated casein |
| Human herpesvirus 3 | - | - | 662601 | - | - | ? |
| ATP + casein | ADP + phosphorylated casein |
| Saccharomyces cerevisiae | - | - | 491608 | - | - | ? |
| ATP + casein | ADP + phosphorylated casein |
| Rattus norvegicus | Q06486 | - | 491628 | - | - | ? |
| ATP + casein | ADP + phosphorylated casein |
| Rattus norvegicus | Q62761, Q62762, Q62763 | - | 491630 | - | - | ? |
| ATP + casein | ADP + phosphorylated casein |
| Saccharomyces cerevisiae | P53323 | - | 532792 | - | - | ? |
| ATP + casein | ADP + phosphorylated casein |
| Rattus norvegicus | - | substrate of CK1 and CK2 | 660948 | - | - | ? |
| ATP + casein | ADP + phosphorylated casein |
| Mus musculus | - | substrate of TSSK3 | 661711 | - | - | ? |
| ATP + casein | ADP + phosphorylated casein |
| Arabidopsis thaliana | - | the chromophoric domain light-oxygen-voltage-sensing 2 LOV2 of phototropin acts as a blue light-regulated molecular switch | 663234 | - | - | ? |
| ATP + Cdc25C | ADP + ? |
| Homo sapiens | - | Chk2 phosphorylated Cdc25C on Ser216 | 491340 | - | - | ? |
| ATP + Cdc25C | ADP + phosphorylated Cdc25C |
| Xenopus laevis | Q6DE87 | - | 491442 | - | - | ? |
| ATP + Cdc25C | ADP + phosphorylated Cdc25C |
| Mus musculus | Q9Z265 | phosphorylated Cdc25C on Ser216 | 491340 | - | - | ? |
| ATP + Cdc42Hs | ADP + ? |
| Homo sapiens | O96013 | PAK4 interacts only with the activated form of Cdc42Hs through its GTPase-binding domain | 491841 | - | - | ? |
| ATP + Cdk2 interacting protein | ADP + phosphorylated Cdk2 interacting protein |
| Homo sapiens | - | - | 708371 | - | - | ? |
| ATP + cell division cycle 7 | ADP + phosphorylated cell division cycle 7 |
| Homo sapiens | - | - | 708371 | - | - | ? |
| ATP + claspin | ADP + phosphorylated claspin |
| Homo sapiens | - | - | 708371 | - | - | ? |
| ATP + claudin-4 | ADP + phosphorylated claudin-4 |
| Rattus norvegicus | - | recombinant WNK1 or WNK4 with recombinant protein substrate, both expressed in Escherichia coli | 661007 | - | - | ? |
| ATP + CPS.A subunit | ADP + phosphorylated-CPS.A subunit |
| Aquifex aeolicus | O66844 | AaSTPK also phosphorylates one threonine residue on the carbamoyl phosphate synthetase, CPS.A subunit | 694132 | - | - | ? |
| ATP + CREB | ADP + phosphorylated CREB |
| Homo sapiens | Q6SA08 | phosphorylation by TSSK5 at Ser133 stimulates the cAMP responsive element/cAMP responsive element binding protein CRE/CREB responsive pathway in recombinant HEK293 cells, i.e. cAMP responsive element binding protein, phosphorylation by TSSK5 at Ser133, no activity with CREB S133A mutant | 660909 | - | - | ? |
| ATP + Daxx | ADP + phosphorylated Daxx |
| Homo sapiens | - | Daxx is a protein acting in TGF-beta-induced JNK activation and in apoptosis, recombinant Daxx expressed as GST-fusion protein in Escherichia coli | 661422 | - | - | ? |
| ATP + DDDDVASLPGLRRR | ADP + ? |
| Rattus norvegicus | Q06486 | - | 491628 | - | - | ? |
| ATP + EmbR | ADP + phosphorylated-EmbR |
| Mycobacterium tuberculosis | Q11053 | PknH phosphorylates the transcriptional regulator EmbR, but not its homologue EmbR2 | 690814 | - | - | ? |
| ATP + eukaryotic protein synthesis initiation factor | ? |
| Bos taurus | - | i.e. eIF-4E, 1 mol phosphate per mol eIF-4E | 645093 | - | - | ? |
| ATP + geminin | ADP + phosphorylated geminin |
| Homo sapiens | - | a cell cycle regulatory protein | 672431 | - | - | ? |
| ATP + Gli protein | ADP + phosphorylated Gli protein |
| Homo sapiens | - | the Gli proteins are important in regulation of Hedgehog signaling, overview | 673856 | - | - | ? |
| ATP + glycogen synthase | ? |
| Bos taurus | - | from rabbit skeletal muscle, mitochondrial protamine kinases, not cytosolic kinase | 645089 | - | - | ? |
| ATP + glycogen synthase | ? |
| Bos taurus | - | phosphorylated at 15% the rate of protamine | 645086, 645089 | - | - | ? |
| ATP + glycogen synthase | ADP + phosphorylated glycogen synthase |
| Homo sapiens | - | glycogen synthase kinase 3, glycogen synthase kinase 3 is involved in the insulin signaling pathway regulating glycogen synthesis via glycogen synthase antagonizing insulin | 660951 | - | - | ? |
| ATP + glycogen synthase kinase 3 | ADP + phosphorylated glycogen synthase kinase 3 |
| Homo sapiens | - | PKB protein kinase, PKB protein kinase, phosphorylation at S21 and S9 | 660951 | - | - | ? |
| ATP + glycogen synthase kinase-3 (GSK-3) fusion protein | ADP + phosphorylated- glycogen synthase kinase-3 fusion protein |
| Homo sapiens | - | - | 692006 | - | - | ? |
| ATP + GST-CREB2 protein | ADP + phosphorylated GST-CREB2 protein |
| Mus musculus | - | - | 672919 | - | - | ? |
| ATP + GST-NFAT3D4-261-365 | ADP + phosphorylated GST-NFAT3D4-261-365 |
| Mus musculus | - | - | 672919 | - | - | ? |
| ATP + histine H2A | ADP + histidine gammaH2A |
| Saccharomyces cerevisiae | - | phosphorylation on serine 129 in vivo | 709941 | Glc7 dephosphorylates histidine gammaH2A in vitro | - | ? |
| ATP + histone | ADP + phosphorylated histone |
| Rattus norvegicus | - | - | 660870 | - | - | ? |
| ATP + histone | ADP + phosphorylated histone |
| Mycobacterium tuberculosis | - | - | 661782 | - | - | ? |
| ATP + histone | ADP + phosphorylated histone |
| Sulfolobus solfataricus | - | - | 680441 | - | - | ? |
| ATP + histone | ADP + phosphorylated histone |
| Archaeoglobus fulgidus | O30245 | - | 663404 | - | - | ? |
| ATP + histone | ADP + phosphorylated histone |
| Mycobacterium tuberculosis | - | histones from calf thymus, phosphorylation on Ser | 532698 | - | - | ? |
| ATP + histone f1 | ? |
| Rattus norvegicus | - | lysine-rich histone, phosphorylated at a specific serine residue | 645085 | - | - | ? |
| ATP + histone fraction II | ? |
| Oncorhynchus mykiss | - | slightly lysine-rich, from trout testes | 645095 | - | - | ? |
| ATP + histone H1 | ADP + phosphorylated histone H1 |
| Homo sapiens | - | - | 491060 | - | - | ? |
| ATP + histone H1 | ADP + phosphorylated histone H1 |
| Homo sapiens | O00311 | - | 532775 | - | - | ? |
| ATP + histone H1 | ADP + phosphorylated histone H1 |
| Homo sapiens | - | PDK2 | 662817 | - | - | ? |
| ATP + histone H1 | ADP + phosphorylated histone H1 |
| Homo sapiens | Q9BXA6 | substrate from calf, substrate of SSTK | 662857 | - | - | ? |
| ATP + histone H1 | ADP + phosphorylated histone H1 |
| Mus musculus | Q925K9 | substrate from calf, substrate of SSTK | 662857 | - | - | ? |
| ATP + histone H1 | ADP + phosphorylated histone H1 |
| Mus musculus | - | substrate of TSSK3 | 661711 | - | - | ? |
| ATP + histone H1 | ? |
| Bos taurus | - | mitochondrial protamine kinases | 645089 | - | - | ? |
| ATP + histone H1 | ? |
| Bos taurus | - | not microsomal kinases | 645090 | - | - | - |
| ATP + histone H1 | ? |
| Bos taurus | - | not cytosolic | 645089 | - | - | ? |
| ATP + histone H1 | ? |
| Bos taurus | - | phosphorylated at 80% the rate of protamine | 645086 | - | - | ? |
| ATP + histone H2A | ADP + phosphorylated histone H2A |
| Homo sapiens | Q9BXA6 | recombinant human substrate, substrate of SSTK | 662857 | - | - | ? |
| ATP + histone H2A | ADP + phosphorylated histone H2A |
| Mus musculus | Q925K9 | recombinant human substrate, substrate of SSTK | 662857 | - | - | ? |
| ATP + histone H2AX | ADP + phosphorylated histone H2AX |
| Homo sapiens | Q9BXA6 | recombinant human substrate, substrate of SSTK | 662857 | - | - | ? |
| ATP + histone H2AX | ADP + phosphorylated histone H2AX |
| Mus musculus | Q925K9 | recombinant human substrate, substrate of SSTK | 662857 | - | - | ? |
| ATP + histone H2B | ADP + phosphorylated histone H2B |
| Homo sapiens | Q9BXA6 | recombinant human substrate, substrate of SSTK | 662857 | - | - | ? |
| ATP + histone H2B | ADP + phosphorylated histone H2B |
| Mus musculus | Q925K9 | recombinant human substrate, substrate of SSTK | 662857 | - | - | ? |
| ATP + histone H3 | ADP + phosphorylated histone |
| Schizosaccharomyces pombe | - | Ark1 phosphorylates Ser10 of histone H3 in vivo | 491212 | - | - | ? |
| ATP + histone H3 | ? |
| Schizosaccharomyces pombe | - | Ark1 phosphorylates Ser10 of histone H3 in vivo | 491212 | - | - | ? |
| ATP + histone H3 | ADP + phosphorylated histone H3 |
| Mus musculus | - | RSK2 is a key regulator of histone H3 phosphorylation | 672919 | - | - | ? |
| ATP + histone H4 | ADP + phosphorylated histone H4 |
| Homo sapiens | Q9BXA6 | recombinant substrate from Xenopus laevis, substrate of SSTK | 662857 | - | - | ? |
| ATP + histone H4 | ADP + phosphorylated histone H4 |
| Mus musculus | Q925K9 | recombinant substrate from Xenopus laevis, substrate of SSTK | 662857 | - | - | ? |
| ATP + histone IIA | ? |
| Sus scrofa | - | poor substrate for cAMP-independent protamine kinase | 645087 | - | - | ? |
| ATP + histone IIB | ? |
| Bos taurus | - | phosphorylated at 8% the rate of protamine, cytosolic kinase | 645089, 645090 | - | - | ? |
| ATP + histone IIB | ? |
| Bos taurus | - | not mitochondrial protamine kinases | 645089 | - | - | ? |
| ATP + histone III | ADP + phosphorylated histone III |
| Arabidopsis thaliana | - | - | 491415 | - | - | ? |
| ATP + hypoxia-inducible factor-1 | ADP + phosphorylated hypoxia-inducible factor-1 |
| Homo sapiens | - | i.e. HIF-1, casein kinase 2 inhibits the activation of HIF-1 activity by phosphorylation and thereby stabilization of the protein, CK2 is involved in and influenced by hypoxia, overview, i.e. HIF-1 | 661900 | - | - | ? |
| ATP + IgG2A heavy chain | ADP + phosphorylated IgG2A heavy chain |
| Human herpesvirus 3 | - | substrate protein from mouse | 662601 | - | - | ? |
| ATP + KKRNRRLSVA | ADP + KKRNRRL-phosphoserine-VA |
| Homo sapiens | - | peptide substrate of NDR1 | 662175 | - | - | ? |
| ATP + KKRNRRLSVA | ADP + phosphorylated-KKRNRRLSVA |
| Homo sapiens | Q15208 | - | 694488 | - | - | ? |
| ATP + lamin A/C | ADP + phosphorylated lamin A/C |
| Human herpesvirus 1 | - | phosphorylation of host cell lamin by US3 kinase, phosphorylation of host cell lamin by US3 kinase at multiple sites in vitro, eventhough lamin A/C contains only one putative consensus sequence | 675712 | - | - | ? |
| ATP + late gene expression factor LEF-8 | ADP + phosphorylated-late gene expression factor LEF-8 |
| Autographa californica nucleopolyhedrovirus | - | - | 695262 | - | - | ? |
| ATP + Lys-Lys-Phe-Asn-Arg-Thr-Leu-Ser-Val-Ala | ADP + ? |
| Homo sapiens | P49137 | - | 491382 | - | - | - |
| ATP + Lys-Lys-Phe-Asn-Arg-Thr-Leu-Ser-Val-Ala | ADP + ? |
| Homo sapiens | - | - | 491383 | - | - | ? |
| ATP + lysozyme | ADP + phopshorylated lysozyme |
| Sulfolobus solfataricus | - | reduced carboxyamidomethylated and maleylated lysozyme | 680441 | - | - | ? |
| ATP + M3-muscarnic receptor | ADP + phosphorylated M3-muscarnic receptor |
| Homo sapiens | - | - | 672431 | - | - | ? |
| ATP + maltose-binding protein | ADP + phosphorylated maltose-binding protein |
| Human herpesvirus 3 | - | - | 662601 | - | - | ? |
| ATP + MARCKS protein | ADP + MARCKS phosphoprotein |
| Homo sapiens | - | isozyme PKNalpha | 662053 | - | - | ? |
| ATP + MB protein | ADP + MB phosphoprotein |
| Homo sapiens | - | - | 662053 | - | - | ? |
| ATP + MCM2 | ADP + ? |
| Homo sapiens | - | wild-type huCdc7 protein expressed in COS7 cells phosphorylates MCM2 and MCM3 proteins in vitro | 532777 | - | - | ? |
| ATP + MCM3 | ADP + ? |
| Homo sapiens | - | wild-type huCdc7 protein expressed in COS7 cells phosphorylates MCM2 and MCM3 proteins in vitro | 532777 | - | - | ? |
| ATP + mPer1 | ADP + phosphorylated mPer1 |
| Rattus norvegicus | Q99PS2, Q9JJ75, Q9JJ76 | CK1epsilon-1 | 662955 | - | - | ? |
| ATP + mPer1 | ADP + phosphorylated mPer1 |
| Rattus norvegicus | Q99PS2, Q9JJ75, Q9JJ76 | CKIepsilon-3 | 662955 | - | - | ? |
| ATP + myelic basic protein | ADP + myelic basic phosphoprotein |
| Mycobacterium tuberculosis | - | phosphorylation of serine and threonine residues by PknB | 662128 | - | - | ? |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Staphylococcus aureus | - | - | 708924 | - | - | ? |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Mycobacterium tuberculosis | - | - | 661782 | - | - | ? |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Sulfolobus solfataricus | - | - | 680448 | - | - | ? |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Archaeoglobus fulgidus | O30245 | - | 663404 | - | - | ? |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Schizosaccharomyces pombe | - | - | 532668 | - | - | ? |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Homo sapiens | Q9BXA6 | - | 662857 | - | - | ? |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Mus musculus | Q925K9 | - | 662857 | - | - | ? |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Homo sapiens | Q6E0B2 | - | 672409 | - | - | ? |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Mus musculus | A3QQQ9, A3QQR1, A9P6P7, A9P6P9 | - | 674390 | - | - | ? |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Mycobacterium tuberculosis | - | myelin basic proteins from bovine brain, phosphorylation on Ser | 532698 | - | - | - |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Mycobacterium tuberculosis | - | PknB, PknD, PknE, and PknF | 660911 | - | - | ? |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Rattus norvegicus | - | recombinant WNK1 or WNK4 expressed in Escherichia coli | 661007 | - | - | ? |
| ATP + myelin basic protein | ADP + phosphorylated myelin basic protein |
| Mus musculus | - | substrate of TSSK3 | 661711 | - | - | ? |
| ATP + myelin basic protein (MBP) | ADP + phosphorylated-myelin basic protein |
| Rattus norvegicus | - | - | 693696 | - | - | ? |
| ATP + NKCC1-(1-260) | ADP + phosphorylated NKCC1-(1-260) |
| Rattus norvegicus | - | i.e. Na+-K+-2Cl- co-transporter-1-(1-260) construct, recombinant WNK1 or WNK4 with recombinant protein substrate, both expressed in Escherichia coli | 661007 | - | - | ? |
| ATP + NS5A protein | ADP + phosphorylated NS5A protein |
| Saccharomyces cerevisiae | - | recombinant NS5A expressed in Sf9 cells, substrate is a hepatitis C virus protein playing a critical role in virus replication and conferring interferon resistance to the virus, the viral protein is phosphorylated by diverse serine/threonine protein kinases, phosphorylation patterns, overview | 662737 | - | - | ? |
| ATP + NS5A protein | ADP + phosphorylated NS5A protein |
| Rattus norvegicus | - | recombinant NS5A expressed in Sf9 cells, substrate is a hepatitis C virus protein playing a critical role in virus replication and conferring interferon resistance to the virus, the viral protein is phosphorylated by several serine/threonine protein kinases, e.g. casein kinase 1, phosphorylation pattern, overview | 662737 | - | - | ? |
| ATP + NS5A protein | ADP + phosphorylated NS5A protein |
| Homo sapiens | - | recombinant NS5A expressed in Sf9 cells, substrate is a hepatitis C virus protein playing a critical role in virus replication and conferring interferon resistance to the virus, the viral protein is phosphorylated by several STE or AGC type protein kinases CK2, AKT1, SGK1, 90S6K, STE, phosphorylation patterns, overview | 662737 | - | - | ? |
| ATP + OdhI | ADP + phosphorylated-OdhI |
| Corynebacterium glutamicum | Q6M299, Q6M3Q8, Q8NU97, Q8NU98 | following phosphorylation by PknA, PknG can transphosphorylate its specific substrate 2-oxoglutarate dehydrogenase inhibitor protein (OdhI) in vitro | 693078 | - | - | ? |
| ATP + ORF62 protein | ADP + ORF62 phosphoprotein |
| Human herpesvirus 3 | - | protein substrate from Varicella-Zoster virus, no activity with a truncated ORF62 mutant | 662601 | - | - | ? |
| ATP + ORF63 protein | ADP + ORF63 phosphoprotein |
| Human herpesvirus 3 | - | protein substrate from Varicella-Zoster virus | 662601 | - | - | ? |
| ATP + oxidative stress response kinase 1 OSR1 | ADP + phosphorylated oxidative stress response kinase 1 OSR1 |
| Rattus norvegicus | - | recombinant WNK1 or WNK4 with recombinant protein substrate, both expressed in Escherichia coli, phosphorylation at Ser325 and Thr185, the latter is required for activation of OSR1 | 661007 | - | - | ? |
| ATP + peptide LRRKtide | ADP + phosphorylated peptide LRRKtide |
| Homo sapiens | - | high activity towards the peptidic substrate LRRKtide | 708481 | - | - | ? |
| ATP + peptide RRRDDDSDDD | ADP + peptide RRRDDDphosphoSDDD |
| Homo sapiens | - | a CK2-specific synthetic peptide substrate | 674068 | - | - | ? |
| ATP + phospho-glycogen synthase peptide | ADP + ? |
| Homo sapiens | - | - | 662388 | - | - | ? |
| ATP + phosphoglucosamine mutase | ADP + phosphorylated phosphoglucosamine mutase |
| Streptococcus pneumoniae | - | - | 661685 | - | - | ? |
| ATP + phosphoglycogen synthase peptide 2 | ADP + phosphorylated phosphoglycogen synthase peptide 2 |
| Homo sapiens | - | - | 662313, 662674 | - | - | ? |
| ATP + phosphoglycogen synthase peptide 2 | ADP + phosphorylated phosphoglycogen synthase peptide 2 |
| Rattus norvegicus | - | - | 662302 | - | - | ? |
| ATP + phospholipase D | ADP + phosphorylated phospholipase D |
| Homo sapiens | - | CKII is involved in 4beta-phorbol 12-myristate 13-acetate-induced phospholipase D activation, of PLD1 or PLD2 activity as well as basal PLD activity | 664864 | - | - | ? |
| ATP + phosvitin | ADP + ? |
| Rattus norvegicus | Q06486 | - | 491628 | - | - | ? |
| ATP + phosvitin | ADP + ? |
| Rattus norvegicus | Q62761, Q62762, Q62763 | - | 491630 | - | - | ? |
| ATP + PKB protein kinase | ADP + phosphorylated PKB protein kinase |
| Homo sapiens | - | PDK1 kinase, phosphorylates Thr308 and Ser473, which is required for activation of PKB, PDK1 kinase | 660951 | - | - | ? |
| ATP + PknG | ADP + phosphorylated-PknG |
| Corynebacterium glutamicum | Q6M299, Q6M3Q8, Q8NU97, Q8NU98 | activation of PknG is part of a phosphorylation cascade mechanism that relies on PknA activity | 693078 | - | - | ? |
| ATP + plant ribosomal proteins | ADP + phosphorylated plant ribosomal proteins |
| Arabidopsis thaliana | - | two plant ribosomal proteins of 14000 Da and 16000 Da can be phosphorylated by the Atpk1 protein kinase | 491151 | - | - | ? |
| ATP + procaspase-2 | ADP + phosphorylated procaspase-2 |
| Homo sapiens | - | phosphorylation of procaspase-2 by CK2 prevents the activation of caspase activity by inhibiting the dimerization of procaspase-2, CK2 activity is involved in the direct regulation of the caspase-8 pathway, where it can control caspase-8 activity through the phosphorylation of ARC or by preventing the ability of caspase-8 to cleave its target Bid | 672431 | - | - | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Sus scrofa | - | - | 645087 | - | - | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Bos taurus | - | - | 645091, 645092, 645093 | - | - | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Oncorhynchus mykiss | - | - | 645094 | - | - | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Rattus norvegicus | - | preferred substrate | 645083 | - | 645083 | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Bos taurus | - | preferred substrate | 645086, 645089 | - | - | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Oncorhynchus mykiss | - | preferred substrate | 645095 | - | 645095 | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Rattus norvegicus | - | phosphorylates threonine residues, phosphorylates serine | 645083 | - | 645083 | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Saccharomyces cerevisiae | - | phosphorylates serine | 645084 | - | 645084 | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Oryctolagus cuniculus | - | phosphorylates serine | 645088 | - | 645088 | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Oncorhynchus mykiss | - | transfers terminal phosphoryl group from ATP into O-phosphoseryl linkages in the acceptor molecule | 645095 | - | 645095 | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Saccharomyces cerevisiae | - | no substrates are rabbit muscle glycogen phosphorylase b, human gamma-globulin | 645084 | - | 645084 | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Bos taurus | - | no substrates are histone H4, ovalbumin, synthetic peptide poly(Glu,Tyr) (4:1) | 645089 | - | - | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Bos taurus | - | phosphorylates little, if any activity with branched-chain alpha-keto acid dehydrogenase, pyruvate dehydrogenase, casein, ovalbumin or histone H2B | 645086 | - | - | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Bos taurus | - | no substrates are GTP | 645089, 645090 | - | - | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Oncorhynchus mykiss | - | no substrates are GTP, no substrates are GTP or UTP | 645095 | - | 645095 | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Rattus norvegicus | - | no substrates are acidic proteins, e.g. casein, phosvitin | 645083 | - | 645083 | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Rattus norvegicus | - | no substrates are acidic proteins, e.g. casein, phosvitin | 645085 | - | 645085 | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Rattus norvegicus | - | no substrates are acidic proteins, e.g. casein, phosvitin | 645096 | - | - | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Saccharomyces cerevisiae | - | no substrates are acidic proteins, e.g. casein, phosvitin | 645084 | - | 645084 | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Oryctolagus cuniculus | - | no substrates are acidic proteins, e.g. casein, phosvitin | 645088 | - | 645088 | ? |
| ATP + protamine | ADP + O-phosphoprotamine |
| Oncorhynchus mykiss | - | phosphorylates histone fraction I (lysine-rich) and histone fractions III and IV (arginine-rich), from trout testes | 645095 | - | 645095 | ? |
| ATP + protein | ADP + protein tyrosine phosphate |
| Mus musculus | - | GST-Limk1-fusion protein can autophosphorylate on serine, tyrosine and threonine residues in vitro | 490484 | - | - | ? |
| ATP + protein | ADP + protein tyrosine phosphate |
| Homo sapiens | P53667 | phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes | 490477 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Homo sapiens | - | - | 707574, 708246 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Homo sapiens | O14965 | - | 709439 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Saccharomyces cerevisiae | Q12469 | - | 491905 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Arabidopsis thaliana | - | autophosphorylation | 491070 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Mus musculus | Q62101 | autophosphorylation | 491198 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Rattus norvegicus | Q63484 | autophosphorylation | 491202 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Saccharomyces cerevisiae | - | autophosphorylation | 491376 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Rattus norvegicus | O88506 | autophosphorylation | 491836 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Schizosaccharomyces pombe | - | autophosphorylation | 532668 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Mus musculus | - | autophosphorylation | 532676 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Rattus norvegicus | Q63285 | autophosphorylation | 532676 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Arabidopsis thaliana | O48963 | blue light-dependent autophosphorylating | 491069 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Mus musculus | Q62101 | Ser916 is an in vivo autophosphorylation site | 491198 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Homo sapiens | P11801 | autophosphorylates exclusively serines within its COOH-terminal region in an intermolecular fashion | 491245 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Mus musculus | - | autophosphorylated in vitro in its PS domain | 491329 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Homo sapiens | - | minimum sequence required for efficient phosphorylation is Xaa-Xaa-Hyd-Xaa-Arg-Xaa-Xaa-Ser-Xaa-Xaa, where Hyd is a bulky hydrophobic residue (in decreasing order), Phe, Leu, Val, Ala, MAPKAP kinase-2 can not tolerate a proline residue at position n + 1 | 491383 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Xenopus laevis | Q91604 | autophosphorylation of Thr192 | 491434 | - | - | - |
| ATP + protein | ADP + phosphoprotein |
| Mus musculus | - | Ser/Thr kinase | 532677 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Schizosaccharomyces pombe | - | phosphotyrosine as well as phosphoserine/threonine are found in autophosphorylation | 532668 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Saccharomyces cerevisiae | - | enzyme is essential for the late nuclear division in the yeast | 491855 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Rattus norvegicus | O88506 | enzyme activates the p38 pathway, SPAK may act as a novel mediator of stress-activated signals | 491836 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Homo sapiens | O96013 | the enzyme is an effector for Cdc42Hs and is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia | 491841 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Candida albicans | O14427 | enzyme is required for virulence and hyphal formation of Candida albicans | 491827 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Mus musculus | O88643, Q61036 | potentially important role in the control of the cellular architecture and/or signaling in the central nervous system | 491839 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Mus musculus | O88643, Q61036 | potentially important role in the control of the cellular architecture and/or signaling in the central nervous system | 491839 | - | - | - |
| ATP + protein | ADP + phosphoprotein |
| Homo sapiens | O75914 | PAK3 may be critical for human cognitive function | 491835 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Homo sapiens | - | the enzyme regulates the structure of the actin cytoskeleton in mammalian cells, and may serve as an effector for effector for Cdc42 and Rac1 in proll motility | 491908 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Saccharomyces cerevisiae | - | the enzyme is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components | 491899 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Saccharomyces cerevisiae | - | the enzyme is necessary for mating | 491900 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Schizosaccharomyces pombe | - | Pak1 protein is likely to be an effector for Cdc42p or a related GTPase, Pak1p may be involved in the maintenance of cell polarity and in mating | 491887 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Saccharomyces cerevisiae | - | the enzyme is involved in budding and cytokinesis and interacts with Cdc42, a GTPase required for polarized cell growth | 491884 | - | - | ? |
| ATP + protein | ADP + phosphoprotein |
| Homo sapiens | Q13153 | hPAK1 is a GTPase effector controlling a downstream MAP kinase pathway. PAK kinase plays a key part in linking extracellular signals from membrane components, such as receptor-associated G proteins and Rho-related GTPases, to nuclear responses, such as transcriptional activation | 491907 | - | - | ? |
| ATP + protein | ADP + a phosphoprotein |
| Homo sapiens | O75716 | - | 532770 | - | - | ? |
| ATP + protein | ADP + a phosphoprotein |
| Homo sapiens | - | - | 532771, 532773 | - | - | ? |
| ATP + protein | ADP + a phosphoprotein |
| Mus musculus | O88697 | - | 532770 | - | - | ? |
| ATP + protein | ADP + a phosphoprotein |
| Mus musculus | - | - | 532771, 532772, 532773, 532774 | - | - | ? |
| ATP + protein | ADP + a phosphoprotein |
| Rattus norvegicus | P57760 | - | 532770 | - | - | ? |
| ATP + protein | ? |
| Mus musculus | - | PKL12 may play a role in a very general cellular function, probably related with the secretory pathway | 532773 | - | - | ? |
| ATP + protein | ? |
| Mus musculus | - | EDPK plays a crucial role in intracellular signaling not only during mouse development but also in adult tissues | 532774 | - | - | ? |
| ATP + protein Cubitus interruptus | ADP + phosphorylated protein Cubitus interruptus |
| Drosophila melanogaster, Xenopus laevis | - | Ci proteins are important in regulation of Hedgehog signaling, overview | 673856 | - | - | ? |
| ATP + protein Cubitus interruptus | ADP + phosphorylated protein Cubitus interruptus |
| Drosophila melanogaster, Xenopus laevis | - | i.e. Ci, e.g. Ci-75 or Ci-155 | 673856 | - | - | ? |
| ATP + protein INI | ADP + phosphorylated INI |
| Homo sapiens | - | INI is a hSWI/SNF protein | 676261 | - | - | ? |
| ATP + protein kinase C | ADP + phosphorylated protein kinase C |
| Homo sapiens | - | isozyme PKNalpha | 662053 | - | - | ? |
| ATP + protein kinase Czeta | ADP + phosphorylated protein kinase Czeta |
| Mus musculus | Q9Z2A0 | phosphorylation and activation of protein kinase Czeta | 491023 | - | - | ? |
| ATP + protein LRP6 | ADP + phosphorylated protein LRP6 |
| Drosophila melanogaster, Homo sapiens, Xenopus laevis | - | CKIgamma | 673856 | - | - | ? |
| ATP + protein p21 | ADP + phosphoprotein p21 |
| Mus musculus | - | threonine 57, threonine 145, serine 98, serine 130, and serine 146 are phosphorylated by JNK, JNK mediates stabilization of protein p21 via the phosphorylation of threonine 57 | 709940 | - | - | ? |
| ATP + protein TCF3 | ADP + phosphorylated protein TCF3 |
| Drosophila melanogaster, Homo sapiens, Xenopus laevis | - | CKIepsilon | 673856 | - | - | ? |
| ATP + ribosomal protein S6 | ADP + phosphorylated ribosomal protein S6 |
| Zea mays | Q6TQF8 | specifically phosphorylated by S6K | 661133 | - | - | ? |
| ATP + RRRLSSLRA | ADP + RRRLSpSLRA |
| Homo sapiens | - | enzyme activities are determined by measuring initial velocities for His6-S6K1aII(DELTA AID)-T389E catalyzed phosphorylation of a commercially available S6K/RSK model peptide substrate 1 (S6K1-Tide, RRRLSSLRA) | 694964 | - | - | ? |
| ATP + RRSSSY | ADP + RRSS-phosphoS-Y |
| Mus musculus | - | peptide substrate of TSSK3 consisting of the consensus sequence | 661711 | - | - | ? |
| ATP + RSK peptide | ADP + RSK phosphopeptide |
| Zea mays | Q6TQF8 | - | 661133 | - | - | ? |
| ATP + RSRSRSRSRSRSPPPVSK | ADP + phosphorylated RSRSRSRSRSRSPPPVSK |
| Homo sapiens | - | SC35-derived peptide 180-197, recombinant GSK-3beta | 662261 | - | - | ? |
| ATP + Rv2175 | ADP + phosphorylated-Rv2175 |
| Mycobacterium tuberculosis | O53510 | - | 695069 | - | - | ? |
| ATP + S6 protein of the 40s ribosomal subunit | ADP + phosphorylated S6 protein of the 40s ribosomal subunit |
| Rattus norvegicus | P67999 | the mitogen-activated protein kinase plays a central role in the control of mRNA translation. It physiologically phosphorylates the S6 protein of the 40s ribosomal subunit in response to mitogenic stimuli and is a downstream component of the rapamycin-sensitive pathway, which includes the 12-kDa FK506 binding protein and includes rapamycin and the 12-kDa FK506 binding protein target 1 | 491116 | - | - | ? |
| ATP + SC35 | ADP + phosphorylated SC35 |
| Homo sapiens | - | substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors, substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors, recombinant GSK-3beta | 662261 | - | - | ? |
| ATP + several 40S ribosomal polypeptides | ? |
| Bos taurus | - | e.g. S6, 2.5 mol phosphate per mol S6 | 645090 | - | - | - |
| ATP + SF2/ASF | ADP + phosphorylated SF2/ASF |
| Homo sapiens | Q13523 | - | 532661 | - | - | ? |
| ATP + SF2/ASF | ADP + phosphorylated SF2/ASF |
| Homo sapiens, Mus musculus | - | SF2/ASF is a human SR splicing factor, phosphorylation in the RS domain | 532666 | - | - | ? |
| ATP + SIV/17E-Fr Nef protein | ADP + phosphorylated SIV/17E-Fr Nef protein |
| Homo sapiens | - | phosphorylation at Ser12, the protein kinase CK2 associates with the Nef proteins from the Human immunodeficiency virus and the macrophage-tropic neurovirulent Simian immunodeficiency virus clone, SIV/17E-Fr, the Nef protein play important roles in viral disease progression, phosphorylation at Ser12, no or poor activity with SIV/17E-Fr Nef protein mutants S12P and D15A, respectively, in transfected 293T cells, Asp15 of the substrate is important for phosphorylation | 677245 | - | - | ? |
| ATP + SR protein | ADP + ? |
| Mus musculus | Q9QZR5 | - | 532680 | - | - | ? |
| ATP + SR protein | ADP + ? |
| Schizosaccharomyces pombe | - | dsk1 protein may play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity | 532668 | - | - | ? |
| ATP + SR protein | ADP + ? |
| Mus musculus | - | enzyme acts as a corepressors for homeodomain transcription factors | 532683 | - | - | ? |
| ATP + SR protein | ADP + ? |
| Mus musculus | - | enzyme regulates the activation and adhesion of T cells. CD43 may mediate its biologic effects through activation of a kinase cascade, resulting in the regulation of cell growth | 532682 | - | - | ? |
| ATP + SR protein | ADP + ? |
| Mus musculus | - | implication of KIS in the control of trafficking and/or splicing of RNAs probably through phosphorylation of associated factors | 532676 | - | - | ? |
| ATP + SR protein | ADP + ? |
| Rattus norvegicus | Q63285 | implication of KIS in the control of trafficking and/or splicing of RNAs probably through phosphorylation of associated factors | 532676 | - | - | ? |
| ATP + SR protein | ADP + ? |
| Homo sapiens | Q9H2X6 | enzyme plays a role as a co-repressor for homeodomain transcription factors | 532680 | - | - | ? |
| ATP + SR protein | ADP + ? |
| Schizosaccharomyces pombe | - | enzyme is essential for growth | 532678 | - | - | ? |
| ATP + SR protein | ADP + ? |
| Drosophila melanogaster | P49762 | enzyme is essential for eye and embryonic development | 532671 | - | - | ? |
| ATP + SR protein | ADP + ? |
| Schizosaccharomyces pombe | - | enzyme may play a role in mitosis | 532668 | - | - | ? |
| ATP + SSH1L protein | ADP + SSH1L phosphoprotein |
| Homo sapiens | - | PKD1 phosphorylates the SSH enzyme SSH1L at serine 978 | 710035 | - | - | ? |
| ATP + stathmin | ADP + phosphorylated stathmin |
| Mus musculus | - | phosphorylates on Ser | 532676 | - | - | ? |
| ATP + stathmin | ADP + phosphorylated stathmin |
| Rattus norvegicus | Q63285 | phosphorylates on Ser | 532676 | - | - | ? |
| ATP + STE/SPS1-related proline/alanine-rich kinase SPAK | ADP + phosphorylated STE/SPS1-related proline/alanine-rich kinase SPAK |
| Rattus norvegicus | - | recombinant WNK1 or WNK4 with recombinant protein substrate, both expressed in Escherichia coli | 661007 | - | - | ? |
| ATP + synaptotagmin 2 | ADP + phosphorylated synaptotagmin 2 |
| Rattus norvegicus | - | WNK1 specific substrate | 663401 | - | - | ? |
| ATP + synthetic peptide | ? |
| Bos taurus | - | Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala | 645090 | - | - | ? |
| ATP + tau protein | ADP + phosphorylated tau protein |
| Homo sapiens | - | tau in Alzheimer disease brain is highly phosphorylated and aggregates into paired helical filaments comprising characteristic neurofibrillary tangles, overview, determination of several phosphorylation sites, e.g. Ser258, Ser289, Ser262, and Ser356 within the microtubule-binding repeats or at Ser184 and Ser185 of the central region, for casein kinase I, casein kinase 2, and glycogen synthase kinase-3beta in insoluble tau, PHF-tau, extracted from Alzheimer brain and of tau from control healthy brain by mass spectrometry, overview | 674847 | - | - | ? |
| ATP + TEM-beta-lactamase | ADP + phosphorylated TEM-beta-lactamase |
| Myxococcus xanthus | P54736 | the enzyme is phosphorylated only at Thr residues, shifting its apparent molecular mass from 29000 Da to 44000 Da. The phosphorylated beta-lactamase is unable to be secreted into the periplasmic space and localized in the cytoplasmic and membrane fractions | 532718 | - | - | ? |
| ATP + testis-specific serine-threonine kinase 3 | ADP + phosphorylated testis-specific serine-threonine kinase 3 |
| Mus musculus | - | substrate of phosphoinositide-dependent kinase-1 leading to activation, substrate of recombinant Myc-tagged catalytic subunit of PDK1 leading to activation | 661711 | - | - | ? |
| ATP + tomato mosaic virus movement protein | ADP + phosphorylated tomato mosaic virus movement protein |
| Nicotiana tabacum | Q8LP30 | recombinant CK2 catalytic subunit, substrate is phosphorylated at S261 and T256 of the C-terminus | 662558 | - | - | ? |
| ATP + Trx-His-S-CREB protein | ADP + phosphorylated Trx-His-S-CREB protein |
| Mus musculus | A3QQQ9, A3QQR1, A9P6P7, A9P6P9 | i.e. thioredoxin fusion cAMP responsive element binding protein, phosphorylation at Ser133 | 674390 | - | - | ? |
| ATP + UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | ADP + phosphorylated-UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase |
| Mycobacterium tuberculosis | P65726 | evidence is provided that mycobacterial mMurD is a substrate of PknA | 690835 | - | - | ? |
| ATP + Varicella-Zoster viral gB protein | ADP + phosphorylated Varicella-Zoster viral gB protein |
| Homo sapiens | - | phosphorylation at S34 in the sequence QSEDIT | 662601 | - | - | ? |
| ATP + vimentin | ADP + phosphorylated vimentin |
| Homo sapiens | - | isozyme PKNalpha | 662053 | - | - | ? |
| ATP + vimentin | ADP + phosphorylated vimentin |
| Mus musculus | Q924X7 | kinase assays demonstrate that Stk33 is able to specifically phosphorylate the non-alpha-helical amino-terminal domain of vimentin in vitro | 691479 | - | - | ? |
| ATP + [FRAT-2 protein] | ADP + phosphorylated [FRAT-2 protein] |
| Homo sapiens | - | i.e. frequently rearranged in advanced T-cell lymphoma protein 2, phosphorylation by GSK3beta | 662388 | - | - | ? |
| ATP + [M3 muscarinic acetylcholine receptor] | ADP + phospho-[M3 muscarinic acetylcholine receptor] |
| Homo sapiens | - | recombinant substrate expressed in HEK-293 and CHO cells, casein kinase 1alpha | 662912 | - | - | ? |
| ATP + [tau-protein] | ADP + O-phospho -[tau-protein] |
| Homo sapiens | - | tau is primarily found in neurons, regulation of tau phosphorylation by GSK3beta via interaction with FRAT-1 and FRAT-2, i.e. frequently rearranged in advanced T-cell lymphoma proteins, phosphorylation of primed and unprimed sites by GSK3beta, wild-type and recombinant tau, recombinant GSK3beta S9A | 662388 | - | - | ? |
| ATP + [tau-protein] | ADP + O-phospho-[tau-protein] |
| Mus musculus | - | - | 662855 | - | - | ? |
| ATP + [tau-protein] | ADP + O-phospho-[tau-protein] |
| Homo sapiens | - | - | 662134, 662261, 662313, 662674, 662855 | - | - | ? |
| ATP + [tau-protein] | ADP + O-phospho-[tau-protein] |
| Bos taurus | - | - | 662127 | - | - | ? |
| ATP + [tau-protein] | ADP + O-phospho-[tau-protein] |
| Rattus norvegicus | - | abnormal hyperphosphorylation of tau by GSK-3 is associated with Alzheimer's disease and other tauopathies leading to neuronal degeneration | 662302 | - | - | ? |
| ATP + [tau-protein] | ADP + O-phospho-[tau-protein] |
| Mus musculus | - | activity in organisms with mutated APP and tau, not in wild-type, overview | 662855 | - | - | ? |
| ATP + [tau-protein] | ADP + O-phospho-[tau-protein] |
| Homo sapiens | - | phosphorylation of tau, especially at the primed epitope T231 negatively regulates tau-microtubule interactions, different effects of phosphorylation on primed T231 and unprimed S396/S404 epitopes of tau, overview | 662313 | - | - | ? |
| ATP + [tau-protein] | ADP + O-phospho-[tau-protein] |
| Homo sapiens | - | substrate of GSK3beta in brain | 660602 | - | - | ? |
| ATP + [tau-protein] | ADP + O-phospho-[tau-protein] |
| Bos taurus | - | substrate of GSK3beta in brain | 662127 | - | - | ? |
| ATP + [tau-protein] | ADP + O-phospho-[tau-protein] |
| Homo sapiens | - | phosphorylation at the C-terminus, lower activity with C-terminally truncated tau D421 compared to the wild-type tau, the truncated tau protein forms sarcosyl-insoluble aggregates | 662134 | - | - | ? |
| ATP + [tau-protein] | ADP + O-phospho-[tau-protein] |
| Rattus norvegicus | - | phosphorylation by GSK-3 at Ser404, Ser396, Ser198, Ser199, and Ser202 | 662302 | - | - | ? |
| ATP + [tau-protein] | ADP + O-phospho-[tau-protein] |
| Homo sapiens | - | substrate of GSK-3 in brain | 662261 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Drosophila melanogaster | - | - | 491654, 491658 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Rattus norvegicus | P19139 | - | 491635 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Rattus norvegicus | - | - | 491648 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Saccharomyces cerevisiae | - | - | 491637 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Saccharomyces cerevisiae | P19454 | - | 491654 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Homo sapiens | - | - | 491639, 491645 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Homo sapiens | P19784, P68400 | - | 491646 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Homo sapiens | - | - | 491648 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Caenorhabditis elegans | P18334 | - | 491642 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Xenopus laevis | P28020 | - | 491643 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Dictyostelium discoideum | Q02720 | - | 491644 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Bos taurus | P20427 | - | 491645 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Gallus gallus | P21868, P21869 | - | 491647 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Arabidopsis thaliana | Q08466 | - | 491649 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Theileria parva | P28547 | - | 491651 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Mus musculus | O54833 | - | 491653 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Schizosaccharomyces pombe | - | - | 491656, 491660 | - | - | ? |
| casein + ATP | phosphorylated casein + ADP |
| Mus musculus | Q60737 | - | 491659 | - | - | ? |
| casein + GTP | phosphorylated casein + GDP |
| Caenorhabditis elegans | P18334 | - | 491642 | - | - | ? |
| casein + GTP | phosphorylated casein + GDP |
| Arabidopsis thaliana | Q08466 | - | 491649 | - | - | ? |
| GTP + AaSTPK | GDP + phosphorylated-AaSTPK |
| Aquifex aeolicus | O66844 | enzyme is autophosphorylated on a threonine residue | 694132 | - | - | ? |
| RRRDDDSDDD + ATP | ? + ADP |
| Bos taurus | P20427 | - | 491645 | - | - | ? |
| GTP + CPS.A subunit | GDP + phosphorylated-CPS.A subunit |
| Aquifex aeolicus | O66844 | - | 694132 | - | - | ? |
| additional information | ? | - | Schizosaccharomyces pombe | O13310 | - | 490946 | - | - | - |
| additional information | ? | - | Neurospora crassa | P38679 | - | 491147 | - | - | - |
| additional information | ? | - | Mus musculus | O35280 | - | 491317 | - | - | - |
| additional information | ? | - | Homo sapiens | - | - | 491424 | - | - | - |
| additional information | ? | - | Xenopus laevis | - | - | 491443 | - | - | - |
| additional information | ? | - | Homo sapiens | P51955, P51956 | - | 532742 | - | - | - |
| additional information | ? | - | Rattus norvegicus | P47196, P47197 | interaction between RAC-PK and protein kinase C | 491157 | - | - | - |
| additional information | ? | - | Homo sapiens | - | guanylate kinase activity | 491321 | - | - | - |
| additional information | ? | - | Drosophila melanogaster | - | stress-induced activation of MAPKAPK-2, in turn, results in the phosphorylation of small heat-shock proteins | 491380 | - | - | - |
| additional information | ? | - | Drosophila melanogaster | - | the 41000 Da polypeptide of the enzyme and the 32000 Da polypeptide both incorporate phosphate during autophosphorylation | 491654 | - | - | - |
| additional information | ? | - | Caenorhabditis elegans | P18334 | enzyme undergoes autophosphorylation | 491642 | - | - | - |
| additional information | ? | - | Homo sapiens | - | LIMK may be involved in developmental or oncogenic processes through interactions with LIM-containing proteins | 490479 | - | - | - |
| additional information | ? | - | Mus musculus | P53668 | Kiz-1 may play distinct roles in dividing cells and in differentiated neurons | 490481 | - | - | - |
| additional information | ? | - | Mus musculus | - | Williams syndrome is a complex neurodevelopmental disorder arising from a microdeletion at Chr band 7q11.23, which results in a hemizygous condition for a number of genes, LIMK1, WBSCR1, and RFC2 | 490483 | - | - | - |
| additional information | ? | - | Homo sapiens | - | LIMK1 may be particularly relevant when explaining cognitive defects observed in WS patients | 490480 | - | - | - |
| additional information | ? | - | Homo sapiens | - | LIM-kinase 1 hemizygosity is implicated in impaired visuospatial constructive cognition | 490478 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | - | the enzyme is part of a growth control pathway which is at least partially redundant with the cAMP pathway | 490974 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | P11792 | the enzyme positively regulates the progression of yeast cells through the G1 phase of the cell cycle | 490972 | - | - | - |
| additional information | ? | - | Homo sapiens | - | deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy | 491051 | - | - | - |
| additional information | ? | - | Homo sapiens | - | AKT1 gene is not a major contributor to susceptibility to type II diabetes mellitus in Ashkenazi Jews | 491034 | - | - | - |
| additional information | ? | - | Homo sapiens | O00141 | K+-channel activation by all three isoforms of serum-dependent and glucocorticoid-dependent protein kinase SGK | 491028 | - | - | - |
| additional information | ? | - | Homo sapiens | - | the enzyme acts in concert with Akt to propagate the effects of PI3K activation within the nucleus and to mediate the biological outputs of PI3K signaling, including cell survival and cell cycle progression | 491050 | - | - | - |
| additional information | ? | - | Arabidopsis thaliana | - | NPH1 is an autophosphorylating flavoprotein photoreceptor mediating phototropic responses in higher plants | 491070 | - | - | - |
| additional information | ? | - | Neurospora crassa | O42626 | the enzyme is required to repress entry into the conidiation program | 491067 | - | - | - |
| additional information | ? | - | Mus musculus | Q9WVC6 | induction of enzymatically active Sgk functions as a key cell survival component in response to different environmental stress stimuli | 491025 | - | - | - |
| additional information | ? | - | Homo sapiens | - | transcript levels are strongly altered during anisotonic and isotonic cell volume changes | 491055 | - | - | - |
| additional information | ? | - | Homo sapiens | P31751 | AKT2 may contribute to the pathogenesis of ovarian carcinomas | 491133 | - | - | - |
| additional information | ? | - | Arabidopsis thaliana | P42818 | enzyme may function in the adaptation of plant cells to cold or high-salt conditions | 491150 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | P22204, P32328 | the DBF20 mRNA is expressed at a low level and not under cell-cycle control | 491121 | - | - | - |
| additional information | ? | - | Aplysia californica | P21901 | kinase plays a part in regulating events associated with fertilization | 491120 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | P22204, P32328 | DBF2 mRNA is expressed under cell-cycle control at or near START | 491121 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | P12688, P18961 | enzyme is required for cell growth | 491102 | - | - | - |
| additional information | ? | - | Arabidopsis thaliana | - | atpk1 is involved in the control of plant growth and development | 491152 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | - | DBF2 is likely to encode a protein kinase that may function in initiation of DNA synthesis and also in late nuclear division | 491122 | - | - | - |
| additional information | ? | - | Rattus norvegicus | Q06226 | the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element | 491177 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element | 491179, 491180 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | induction of sgk gene may be associated with a series of axonal regenerations after brain injury, and in addition, the sgk gene may also play important roles in the development of particular groups of neurons in the postnatal brain | 491179 | - | - | - |
| additional information | ? | - | Arabidopsis thaliana | P42818 | may function in the adaptation of plant cells to cold or high-salt conditions | 491150 | - | - | - |
| additional information | ? | - | Rattus norvegicus | Q06226 | enzyme is induced during ovarian cell differentiation | 491177 | - | - | - |
| additional information | ? | - | Homo sapiens | - | T-PK may have specialized functions in different areas of central nervous system. Alterations of this complex expression pattern can be responsible for the mental status impairment observed in myotonic dystrophy patients | 491181 | - | - | - |
| additional information | ? | - | Homo sapiens | - | enzyme may have a role in the development of mental symptoms in severe cases of myotonic dystrophy | 491183 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | the enzyme is highly regulated at the transcriptional level by glucocorticoid hormones | 491180 | - | - | - |
| additional information | ? | - | Rattus norvegicus | Q06226 | SGK is a component of the phosphoinositide 3 (PI 3)-kinase signaling pathway | 491177 | - | - | - |
| additional information | ? | - | Mus musculus | Q9Z1M4 | enzyme is important for cell growth | 491210 | - | - | - |
| additional information | ? | - | Homo sapiens | P51812 | mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation | 491158 | - | - | - |
| additional information | ? | - | Homo sapiens | - | mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation | 491159, 491160 | - | - | - |
| additional information | ? | - | Homo sapiens | Q9UK32 | ribosomal S6-kinase RSK4 is commonly deleted in patients with complex X-linked mental retardation, RSK4 plays a role in normal neuronal development. RSK4 is completely deleted in eight patients with the contiguous gene syndrome including MRX, partially deleted in a patient with DFN3 and present in patients with an Xq21 deletion and normal intellectual abilities | 491208 | - | - | - |
| additional information | ? | - | Homo sapiens | - | decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy | 491184 | - | - | - |
| additional information | ? | - | Homo sapiens | - | inherited defects in insulin-stimulated activation of muscle glycogen synthesis in patients with insulin-resistant NIDDM may be located further upstream of ISPK-1 in the insulin action cascade | 491161 | - | - | - |
| additional information | ? | - | Mus musculus | Q60823 | Akt2 expression is activated during cellular differentiation and suggest that it functions in the signaling pathways of some adult tissues | 491196 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | associates with mitotic structures in a stage dependent manner and is required for chromosome segregation | 491212 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | P24719 | protein kinase is required for meiotic recombination | 491262 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | P38991 | type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation, required during the later part of each cell cycle | 491271 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | - | required for chromosome synapsis and recombination | 491264 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | - | enzyme plays a critical role in regulation by carbon catabolite repression | 491342 | - | - | - |
| additional information | ? | - | Mus musculus | O88866 | the enzyme plays a role in development | 491333 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | nim1+ is a negative regulator of the wee1+ mitotic inhibitor, another protein kinase homolog. The combined mitotic induction activities of nim1+ and cdc25+ counteract the wee1+ mitotic inhibitor in a regulatory network that appears also to involve the cdc2+ protein kinase, which is required for mitosis | 491344 | - | - | - |
| additional information | ? | - | Homo sapiens, Mus musculus | - | Chk1 acts as an integrator for Atm and Atr signals and may be involved in monitoring the processing of meiotic recombination CHK1 gene is a candidate tumor suppressor gene | 491318 | - | - | - |
| additional information | ? | - | Drosophila melanogaster | - | enzyme plays a role in germ line establishment | 491327 | - | - | - |
| additional information | ? | - | Homo sapiens | - | kinase functions downstream of ATM protein in the cellular response to DNA damage | 491337 | - | - | - |
| additional information | ? | - | Homo sapiens | - | in response to DNA damage, Chk1 phosphorylates and inhibits Cdc25C, thus preventing activation of the Cdc2-cyclin B complex and mitotic entry | 491317 | - | - | - |
| additional information | ? | - | Homo sapiens | - | in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis | 491340 | - | - | - |
| additional information | ? | - | Mus musculus | Q9Z265 | in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis | 491340 | - | - | - |
| additional information | ? | - | Homo sapiens | - | heterozygous germ line mutations in hCHK2 occur in Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in the TP53 gene. hCHK2 is a tumor suppressor gene conferring predisposition to sarcoma, breast cancer, and brain tumors | 491339 | - | - | - |
| additional information | ? | - | Mus musculus | O70405 | Unc51.1 signals the program of gene expression leading to the formation of granule cell axons | 491328 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | required to give a normal cell cycle response to nitrogen starvation | 491343 | - | - | - |
| additional information | ? | - | Oryctolagus cuniculus | Q9GM70 | kinase-related apoptosis-inducing protein kinase 1 may play an important role in the core apoptosis program in osteoclast | 491311 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | required for alteration of growth polarity and actin localization | 491314 | - | - | - |
| additional information | ? | - | Homo sapiens | O15075 | likely role for DCAMKL1 transmembrane protein in developing and adult brain, possibly in a pathway of cortical development | 491322 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | Cdc25 mitotic inducer is targeted by chk1 DNA damage checkpoint kinase | 491364 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | - | enzyme controls the DNA damage response | 491376 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | enzyme mediates checkpoint pathway | 491363 | - | - | - |
| additional information | ? | - | Drosophila melanogaster | - | required for pattern formation within embryonic segments and imaginal discs, possible roles of the FUSED protein in signal transduction pathways required for intercellular communication at different stages of development | 491356 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | P38990 | Pak1 may function by modifying and partially stabilizing thermolabile DNA polymerases, perhaps during DNA repair | 491373 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | chk1 protein kinase links the rad checkpoint pathway to cdc2 | 491366 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | P38147 | Chk1 is required for function of the DNA damage checkpoint in Saccharomyces cerevisiae | 491348 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | P22987 | important for growth polarity | 491355 | - | - | - |
| additional information | ? | - | Candida albicans | P52497 | enzyme is essential for the derepression of catabolic repression | 491391 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | P53104 | the enzyme is required for the autophagic process in Saccharomyces cerevisiae | 491392 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | Q12263 | deletion of GIN4 is not lethal but leads to a striking reorganization of the septins accompanied by morphogenetic abnormalities and a defect in cell separation | 491420 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | the enzyme is a regulator of G2/M progression and cytokinesis | 491408 | - | - | - |
| additional information | ? | - | Homo sapiens | Q15831 | mutations of STK11 cause Peutz-Jeghers syndrome | 491422 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | kinase Cdr2 regulates the onset of mitosis in fission yeast | 491407 | - | - | - |
| additional information | ? | - | Homo sapiens | - | Peutz-Jeghers syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer, germline mutations in STK11, probably in conjunction with acquired genetic defects of the second allele in somatic cells, cause the manifestations of PJ syndrome | 491423 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | enzyme plays a major role in the regulation of lipid metabolism, be involved in the regulation of a wide range of metabolic pathways | 491418 | - | - | - |
| additional information | ? | - | Secale cereale | Q02723 | RKIN1 protein has a role in the control of carbon metabolism in endosperms of rye | 491413 | - | - | - |
| additional information | ? | - | Xenopus laevis | Q6DE87 | Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control | 491442 | - | - | - |
| additional information | ? | - | Candida glabrata | Q00372 | the enzyme is essential for the derepression of glucose repression, interacts with additional regulatory pathways and affects the expression of multiple target genes | 491409 | - | - | - |
| additional information | ? | - | Xenopus laevis | Q6DE87 | the damage/replication G2 checkpoint kinase Chk1 phosphorylates and inhibits Cdc25C, a Cdc2 Tyr-15 phosphatase, thereby directly linking the G2 checkpoint to negative regulation of Cdc2. Might function either as a G2 checkpoint kinase or as an ordinary cell cycle regulator in prophase-I-arrested oocytes | 491442 | - | - | - |
| additional information | ? | - | Homo sapiens | - | Peutz-Jeghers syndrome is the first cancer-susceptibility syndrome to be identified that is due to inactivating mutations in a protein kinase, STK11 | 491425 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | the enzyme is a key component of the DNA replication-monitoring S/G2 checkpoint system. Its primary role is to monitor DNA synthesis by interacting with DNA polymerase alpha and send a signal to block the onset of mitosis while DNA synthesis is in progress | 491419 | - | - | - |
| additional information | ? | - | Oryza sativa | P53682 | enzyme is involved in the synthesis of seed storage compounds during seed development | 491401 | - | - | - |
| additional information | ? | - | Arabidopsis thaliana | Q38997 | may play an important role in a signal transduction cascade regulating gene expression and carbohydrate metabolism | 491428 | - | - | - |
| additional information | ? | - | Caenorhabditis elegans | Q23023 | protein phosphorylation by the unc-51 product is important for axonal elongation and possibly for axonal guidance | 491427 | - | - | - |
| additional information | ? | - | Dictyostelium discoideum | Q02720 | the enzyme is essential for vegetative growth of Dictyostelium discoideum, the alpha subunit is expressed constitutively like its mRNA during the life cycle | 491644 | - | - | - |
| additional information | ? | - | Rattus norvegicus | P19139 | enzyme is implicated in the control of cell growth and proliferation. Androgenic regulation of CK-2 gene transcription is not an early event related to androgen action, but is substantial in the prereplicative phase of prostatic cell proliferation mediated by androgen. Androgenic stimulation of the mRNA expression for the alpha and beta subunits of CK-2 appears to be differential | 491635 | - | - | - |
| additional information | ? | - | Caenorhabditis elegans | P18334 | translational and/or post-translational mechanisms play an important role in the developmental regulation of casein kinase II activity | 491642 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | plays a role in the translation of cell polarity into polarized growth, but not in the establishment of polarity itself | 491660 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | key regulatory enzyme involved in many cellular processes, including the control of growth and cell division | 491656 | - | - | - |
| additional information | ? | - | Mus musculus | Q60737 | the casein kinase II gene can serve as an oncogene, and its dysregulated expression is capable of transforming lymphocytes in a two-step pathway with c-myc | 491659 | - | - | - |
| additional information | ? | - | Mus musculus | O54833 | unbalanced expression of CK2 catalytic subunit synergizes with Ha-ras in cell transformation | 491653 | - | - | - |
| additional information | ? | - | Homo sapiens | Q13523 | NH2-terminal region of hPRP4 may play regulatory roles under an unidentified signal transduction pathway through Clk1 | 532661 | - | - | - |
| additional information | ? | - | Homo sapiens | - | enzyme is involved in pre-mRNA splicing | 532666 | - | - | - |
| additional information | ? | - | Homo sapiens | - | calmodulin-binding region of titin can play a regulatory role for the enzyme | 532691 | - | - | - |
| additional information | ? | - | Schizosaccharomyces pombe | - | the cek1+ gene is not an essential gene. Protein phosphorylation by cek1 may facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein | 532689 | - | - | - |
| additional information | ? | - | Homo sapiens | Q13043, Q13188 | enzyme may function at an early step in phosphorylation events that are specific responses to some forms of chemical stress or extreme heat shock | 532741 | - | - | - |
| additional information | ? | - | Homo sapiens | P51955, P51956 | Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2, may function at the onset of mitosis | 532742 | - | - | - |
| additional information | ? | - | Streptomyces coelicolor | - | AfsK is a Hanks-type protein kinase | 662578 | - | - | - |
| additional information | ? | - | Mycobacterium tuberculosis | - | enzyme is involved in stress response and adaptation to environmental changes in mycobacteria | 661782 | - | - | - |
| additional information | ? | - | Bos taurus | - | glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26, phosphorylating tau protein at serine and threonine residues | 662127 | - | - | - |
| additional information | ? | - | Homo sapiens | - | GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview | 662261 | - | - | - |
| additional information | ? | - | Homo sapiens | - | GSK3beta works coordinatedly with PKA, EC 2.7.11.11, on tau phosphorylation | 662674 | - | - | - |
| additional information | ? | - | Homo sapiens | - | HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in hepatoma cells, HIPK2 triggers promyelotic leukemia nuclear body disruption and release of Daxx | 661422 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | isozyme RSK1, i.e. 14-3-3, is regulated by inhibitory binding of 14-3-3beta, a RSK1-binding protein, to Lys49 of the enzyme, Lys49 is also responsible for interaction of RSK1 with Bcr, Raf, and Cbl | 662133 | - | - | - |
| additional information | ? | - | Archaeoglobus fulgidus | O30245 | kinase Rio2 is required for rRNA cleavage in 40S ribosomal subunit maturation | 663404 | - | - | - |
| additional information | ? | - | Homo sapiens | - | mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase | 662175 | - | - | - |
| additional information | ? | - | Mus musculus | - | mechanism of S6K2 regulation via phosphorylation and autoinhibition with T338 playing the key role, S6K2 is regulated in a mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase MEK-dependent manner, overview | 660953 | - | - | - |
| additional information | ? | - | Homo sapiens | - | naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of organisms with Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering Alzheimer's disease leads to age-dependent memory deficits | 662855 | - | - | - |
| additional information | ? | - | Mus musculus | - | naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of patients suffering Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering Alzheimer's disease leads to age-dependent memory deficits | 662855 | - | - | - |
| additional information | ? | - | Nicotiana tabacum | Q9SDY2 | NTHK2 is an ethylene receptor protein | 663129 | - | - | - |
| additional information | ? | - | Homo sapiens | - | phosphorylated tau is important in cytoskeleton assembly | 662134 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis | 662407 | - | - | - |
| additional information | ? | - | Arabidopsis thaliana | - | photoregulation of phototropin, overview | 663234 | - | - | - |
| additional information | ? | - | Homo sapiens | - | PKD2 regulation involving ligand-binding domains of the enzyme, isozyme PKD2 might play a role in the nucleus after activation by G protein-coupled receptors, overview, intracellular trafficking of PKD2, overview | 662817 | - | - | - |
| additional information | ? | - | Streptococcus pneumoniae | - | protein kinase StkP and Mn2+-dependent cytosolic protein phosphatase PhpP act as a functional pair in vivo | 661685 | - | - | - |
| additional information | ? | - | Drosophila melanogaster, Bos taurus, Caenorhabditis elegans, Asteroidea | - | regulation mechanism and biological function of PKN | 662053 | - | - | - |
| additional information | ? | - | Mus musculus | - | regulation mechanism and biological function of PKN, PKNalpha is involved in insulin-induced actin cytoskeleton reorganization and cell adhesion, overview, isozyme PKNalpha is involved in glucose transport in 3T3/L1 cells | 662053 | - | - | - |
| additional information | ? | - | Homo sapiens | - | regulation mechanism and biological function of PKN, PKNalpha is involved in insulin-induced actin cytoskeleton reorganization and cell adhesion, overview, PKNalpha is involved in vesicle transport in the endoplasmic reticulum, PKNalpha is cleaved by caspase-3 or related proteases in apoptotic Jurkat and U-937 cells contributing to signal transduction, PKN interacts with papillomaviral oncoproteins being involved in tumorigenesis, overview | 662053 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | regulation mechanism and biological function of PKN, PKNalpha is involved in insulin-induced actin cytoskeleton reorganization, overview | 662053 | - | - | - |
| additional information | ? | - | Xenopus laevis | - | regulation mechanism and biological function of PKN, the enzyme is involved in cell cycle control | 662053 | - | - | - |
| additional information | ? | - | Homo sapiens | Q9BXA6 | serine/threonine protein kinase is SSTK essential for male fertility | 662857 | - | - | - |
| additional information | ? | - | Mus musculus | Q925K9 | serine/threonine protein kinase SSTK is essential for male fertility, a DNA condensation defect in SSTK null mutants occurred in elongating spermatids at a step in spermiogenesis coincident with chromatin displacement of histones by transition proteins | 662857 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain, inhibition of tau hyperphosphorylation inhibits an associated loss in spatial memory | 662302 | - | - | - |
| additional information | ? | - | Homo sapiens | - | the enzyme participates in Alzheimer's disease | 660602 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | WKN1 and WKN4 are involved in regulation of ion transport across diverse epithelia, WKN4 reduces the activity of Na-Cl-cotransporter activity and the potassium channel ROMK by reducing their appearance in the plasma membrane | 660870 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | WNK1 causes a hereditary form of hypertension, pseudohypoaldosteronism type II | 663401 | - | - | - |
| additional information | ? | - | Streptomyces coelicolor | - | AfsK, PkaG, and SCD10 perform autophosphorylation | 662578 | - | - | - |
| additional information | ? | - | Homo sapiens | - | CKII phosphorylates serine or threonine residues with an acidic amino acid in the +2 or +3 position | 662601 | - | - | - |
| additional information | ? | - | Arabidopsis thaliana | - | enzyme assay under dim red light conditions, phototropin performs autophosphorylation | 663234 | - | - | - |
| additional information | ? | - | Xenopus laevis, Caenorhabditis elegans, Asteroidea | - | enzyme performs autophosphorylation, PKN binds several associated proteins via its ACC domain | 662053 | - | - | - |
| additional information | ? | - | Mus musculus, Homo sapiens, Rattus norvegicus, Bos taurus | - | enzyme performs autophosphorylation, PKN binds several associated proteins via its ACC domain, i.e. RhoA, a small GTPase, which binds to the ACC domain of PKNalpha forming a catalytic active site | 662053 | - | - | - |
| additional information | ? | - | Drosophila melanogaster | - | enzyme performs autophosphorylation, PKN binds several associated proteins via its ACC domain, i.e. RhoA, a small GTPase, which binds to the ACC domain of PKNalpha forming a catalytic active site, isozyme PRK2/PKNgamma/PAK-2 binds to the large non-transmembrane protein Tyr phosphatase PTP-BL involved in the modulation of cytoskeleton, mediated by PSD-95 | 662053 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | GSK-3 catalyzes tau phosphorylation in the brain, while it performs phosphorylation of glycogen synthase and other proteins in other tissues | 662302 | - | - | - |
| additional information | ? | - | Mus musculus, Homo sapiens | - | GSK-3alphabeta catalyzes tau phosphorylation in brain, but phosphorylation of glycogen synthase and other proteins, EC 2.7.11.1, in different tissues | 662855 | - | - | - |
| additional information | ? | - | Homo sapiens | - | GSK3beta catalyzes tau phosphorylation in brain, EC 2.7.11.26, but phosphorylation of glycogen synthase and other proteins in different tissues | 662313, 662674 | - | - | - |
| additional information | ? | - | Homo sapiens | - | GSK3beta catalyzes tau phosphorylation, EC 2.7.11.1, in brain, but phosphorylation of glycogen synthase and other proteins in different tissues | 662388 | - | - | - |
| additional information | ? | - | Homo sapiens | - | GSK3beta catalyzes tau phosphorylation, EC 2.7.11.26, in brain, but phosphorylation of glycogen synthase and other proteins in different tissues | 662134 | - | - | - |
| additional information | ? | - | Homo sapiens | - | NDR1 performs autophosphorylation at S281, T444, and T74 dependent on intracellular Ca2+ | 662175 | - | - | - |
| additional information | ? | - | Nicotiana tabacum | Q709M0, Q709M1 | PK1 performs autophosphorylation | 663396 | - | - | - |
| additional information | ? | - | Nicotiana tabacum | Q709M0, Q709M1 | PK2 performs autophosphorylation | 663396 | - | - | - |
| additional information | ? | - | Homo sapiens | - | PKD2 performs autophosphorylation | 662817 | - | - | - |
| additional information | ? | - | Mycobacterium tuberculosis | - | PknB performs autophosphorylation | 662128 | - | - | - |
| additional information | ? | - | Mycobacterium tuberculosis | - | PknB, PknD, PknE, and PknF perform autophosphorylation | 660911 | - | - | - |
| additional information | ? | - | Mycobacterium tuberculosis | - | PknH performs autophosphorylation | 661782 | - | - | - |
| additional information | ? | - | Archaeoglobus fulgidus | O30245 | Rio2 performs autophosphorylation | 663404 | - | - | - |
| additional information | ? | - | Streptococcus pneumoniae | - | StkP performs autophosphorylation, StkP is dephosphorylated by PhpP, a PP2C-type protein phosphatase | 661685 | - | - | - |
| additional information | ? | - | Homo sapiens | - | substrate ABC transporter protein structure, phosphorylation of the ABCA1 transporter reduces its flippase activity, overview | 662260 | - | - | - |
| additional information | ? | - | Nicotiana tabacum | Q9SDY2 | substrate specificity of full-length enzyme and truncated mutant enzymes, overview, NTHK2 kinase performs autophosphorylation, the enzyme shows Mn2+-dependent serine/threonine kinase and Ca2+-dependent histidine kinase, EC 2.7.13.3, activities | 663129 | - | - | - |
| additional information | ? | - | Homo sapiens | - | substrate specificity of GSK3beta | 660602 | - | - | - |
| additional information | ? | - | Homo sapiens | - | substrate specificity of PDK1, PDK1 binds the hydrophobic motif of substrates via its PIF pocket, GSK3 substrates need to bind tightly to the enzyme for phosphorylation | 660951 | - | - | - |
| additional information | ? | - | Mus musculus | Q925K9 | substrate specificity with diverse peptide substrates, overview, SSTK forms stable complexes with heat shock signal proteins HSP90-1beta, HSC70, and HSP70-1, which seems to be necessary for activity | 662857 | - | - | - |
| additional information | ? | - | Homo sapiens | Q9BXA6 | substrate specificity with diverse peptide substrates, overview, SSTK forms stable complexes with heat shock signate proteins HSP90-1beta, HSC70, and HSP70-1, which seems to be necessary for activity | 662857 | - | - | - |
| additional information | ? | - | Human herpesvirus 3 | - | the minimal consensus sequence of ORF47 is S/T-X-D/E-D/E, no activity of ORF47 with glutathione S-transferase, or Varicella-Zoster viral gB protein | 662601 | - | - | - |
| additional information | ? | - | Mus musculus | - | TSSK3 performs autophosphorylation | 661711 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | WKN1 and WKN4 perform autophosphorylation | 660870 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | WNK1 interacts with OSR1 and SPAK, overview | 661007 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | WNK1 performs autophosphorylation at S382 for activation | 663401 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling by activation of Akt and inactivation of SGK1 through protein phosphatase 2A | 675550 | - | - | - |
| additional information | ? | - | Homo sapiens | - | CK2 is a highly conserved serine/threonine kinase involved in several intracellular pathways, which control, among others, cell cycle, proliferation, apoptosis and transformation, overview, protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview | 674068 | - | - | - |
| additional information | ? | - | Homo sapiens | - | CK2 is involved in phosphorylation of a large portion of the proteome, overview, increased enzyme activity in associated with a number of pathological processes, including cancer, infectious diseases, neurodegeneration, and cardiovascular pathologies playing a global anti-apoptotic role, overview | 671945 | - | - | - |
| additional information | ? | - | Homo sapiens | - | CK2 phosphorylates about 300 different cellular proteins, ranging from transcription factors to proteins involved in chromatin structure and cell division, CK2 induces neoplastic growth when overexpressed | 677230 | - | - | - |
| additional information | ? | - | Homo sapiens | - | CK2 plays a role in the protection of cells from apoptosis via the regulation of tumor suppressor and oncogene activity and stability, e.g. in the NF-kappaB or the Wnt signaling pathways, molecular mechanisms, detailed overview, CK2 activity is linked to Her-2/neu oncogene, which is overexpressed in 30% of breast cancers, regulation of apoptotic machinery by CK2 and its anti-apoptotic effect, overview, role of CK2 in chromosomal DNA strand break repair and the maintenance of genomic integrity, mutational study, overview | 672431 | - | - | - |
| additional information | ? | - | Homo sapiens | - | high CK2 activity occurs in solid tumors due to growth-related functions and to suppression of cellular apoptosis, nuclear localization of domain CK2alpha is associated with high-grade tumors and a poor prognostic factor, overview | 673433 | - | - | - |
| additional information | ? | - | Homo sapiens | - | members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt, overview | 676261 | - | - | - |
| additional information | ? | - | Drosophila melanogaster, Homo sapiens, Xenopus laevis | - | multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase | 673856 | - | - | - |
| additional information | ? | - | Mus musculus | A3QQQ9, A3QQR1, A9P6P7, A9P6P9 | phosphorylation on serine/threonine or tyrosine residues of target proteins is an essential and significant regulatory mechanism in signal transduction during many cellular and life processes, including spermatogenesis, oogenesis and fertilization, overview | 674390 | - | - | - |
| additional information | ? | - | Mus musculus | - | RSK2 is a critical serine/threonine kinase for the regulation of cell transformation, RSK is regulated by the tumor promoters epidermal growth factor EGF or 12-O-tetradecanoylphorbol-13-acetate, TPA, overview | 672919 | - | - | - |
| additional information | ? | - | Synechocystis sp. | - | SpkA is a regulator of expression of three putative pilA operons, formation of thick pili, and cell motility, DNA microarray and electron microscopy analysis, overview | 674308 | - | - | - |
| additional information | ? | - | Human herpesvirus 1 | - | the enzyme alters localization of lamin A/C in infected cells, recombinantly expressed lamin as GFP-tagged protein in Hep-G2 cells, enzyme inactivation causes capsids to aggregate aberrantly between the inner and outer nuclear membranes within evaginations/extensions of the perinuclear space, overview, US3 kinase activity regulates HSV-1 capsid nuclear regress at least in part by phosphorylation of lamin A/C | 675712 | - | - | - |
| additional information | ? | - | Homo sapiens | - | the enzyme inhibits NF-kappaB activity via interaction with the leucine-rich repeat domain of the Salmonella enterica serovar typhimurium-derived effector SspH1 in infected intestine-407 cells, overview | 672994 | - | - | - |
| additional information | ? | - | Homo sapiens | Q6E0B2 | the enzyme is involved in the inflammation cascade in intestine and colon epithelium | 672409 | - | - | - |
| additional information | ? | - | Streptococcus pneumoniae | - | the eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae, and is important for the resistance of the organism to various stress conditions, StkP positively controls the transcription of a set of genes encoding functions involved in cell wall metabolism, pyrimidine biosynthesis, DNA repair, iron uptake, and oxidative stress response, overview | 674332 | - | - | - |
| additional information | ? | - | Homo sapiens | - | CK2 contains a consensus sequence in which a carboxylic acid side chain at position n+3 relative to the target serine/threonine residue plays a crucial role for activity, CK2 shows a broad substrate specificity of diverse proteins | 671945 | - | - | - |
| additional information | ? | - | Rattus norvegicus | - | CK2 inhibition increases SGK1 phosphorylation at Ser422 | 675550 | - | - | - |
| additional information | ? | - | Homo sapiens | - | members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt, however, no Akt consensus sequences are found on BRG1, hBrm, BAF60, BAF57, or on INI1, overview | 676261 | - | - | - |
| additional information | ? | - | Mus musculus | A3QQQ9, A3QQR1, A9P6P7, A9P6P9 | only splicing variant TSSK5alpha exhibits kinase activity | 674390 | - | - | - |
| additional information | ? | - | Homo sapiens | - | protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview | 674068 | - | - | - |
| additional information | ? | - | Mus musculus | A3QQQ9, A3QQR1, A9P6P7, A9P6P9 | splicing variant TSSK5beta is inactive | 674390 | - | - | - |
| additional information | ? | - | Mus musculus | A3QQQ9, A3QQR1, A9P6P7, A9P6P9 | splicing variant TSSK5delta is inactive | 674390 | - | - | - |
| additional information | ? | - | Mus musculus | A3QQQ9, A3QQR1, A9P6P7, A9P6P9 | splicing variant TSSK5gamma is inactive | 674390 | - | - | - |
| additional information | ? | - | Streptococcus pneumoniae | - | StkP performs autophosphorylation | 671795 | - | - | - |
| additional information | ? | - | Homo sapiens | - | the catalytic kinase domain, residues 561-942, of PKN1 is active with out the regulatory domain | 672994 | - | - | - |
| additional information | ? | - | Homo sapiens | - | the pleiotropic protein kinase CK2 possesses many protein interaction sites | 677230 | - | - | - |
| additional information | ? | - | Sulfolobus solfataricus | - | the enzyme performs autophosphorylation in vitro | 680439 | - | - | - |
| additional information | ? | - | Homo sapiens | - | enzyme binds both soluble inositol polyphosphates and inositol phospholipids | 691787 | - | - | - |
| additional information | ? | - | Saccharomyces cerevisiae | - | Glc7 promotes resumption of DNA replication by inactivating Rad53 | 709941 | - | - | - |
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