Information on EC 2.4.2.30 - NAD+ ADP-ribosyltransferase:
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EC NUMBERCOMMENTARY
2.4.2.30-

RECOMMENDED NAMEGeneOntology No.
NAD+ ADP-ribosyltransferaseGO:0003950

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
show the reaction diagram		----
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
show the reaction diagram		E219 and Gln217 of the ARTT-motif, i.e. ADP-ribosylating turn-turn motif, are essential for activityClostridium limosum-672048
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
show the reaction diagram		the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domainsHomo sapiensO95271, P09874, Q2NL67, Q460N5, Q8N5Y8, Q9NR21, Q9UGN5, Q9UKK3, Q9Y6F1672801
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
show the reaction diagram		the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domainsMus musculus-672801
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
show the reaction diagram		mechanism and physiological function, overviewMus musculus-672969
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
show the reaction diagram		L428 is essential for activityPseudomonas aeruginosa-673573

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
pentosyl group transfer----

PATHWAYKEGG LinkMetaCyc Link
No entries in this field

SYSTEMATIC NAMEIUBMB Comments
NAD+:poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferaseThe ADP-D-ribosyl group of NAD+ is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20--30 units.

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-protein----
193-kDa vault protein ----
adenosine diphosphate ribosyltransferase----
ADP-ribosyltransferase----
ADP-ribosyltransferasePseudomonas aeruginosa--672150, 672996, 673573, 694800, 695219
ADP-ribosyltransferase (polymerizing)----
ADP-ribosyltransferase C3cerBacillus cereus--658013
ADP-ribosyltransferase-1Mus musculus--659225
ADPrPseudomonas aeruginosa--695219
ADPRTPseudomonas aeruginosa--661877, 672150, 694800
ADPRT ----
ARTaseClostridium perfringens--657492
asparagine-specific ADP-ribosyltransferaseClostridium limosum--672048
B aggressive lymphoma protein 2Homo sapiensO95271, P09874, Q2NL67, Q460N5, Q8N5Y8, Q9NR21, Q9UGN5, Q9UKK3, Q9Y6F1-672801
C3 exoenzyme----
C3limClostridium limosum--672048
CRM66Pseudomonas aeruginosa--662087
ecto-ADP-ribosyltransferase 2.2Rattus norvegicus--657940
ecto-ADP-ribosyltransferase ART2.2Mus musculus--658344
Exo53Pseudomonas aeruginosa--661986
exoenzyme C3----
exoenzyme C3Clostridium limosum--672048
exoenzyme S----
exoenzyme SPseudomonas aeruginosa--660947, 661051, 661055, 661065, 661865, 661866, 661868, 661871, 661873, 661877, 661903, 661986, 662089, 662103, 672150, 673573, 694800, 695219
exoenzyme TPseudomonas aeruginosa--661784
ExoSPseudomonas aeruginosa--660947, 661065, 661873, 661876, 661903, 661986, 662888, 662890, 672150, 672996, 673573, 694800, 695219
ExoSPseudomonas aeruginosa-bifunctional type-III cytotoxin. Residues 96–233 comprise the Rho GTPase-activating protein domain, while residues 234–453 comprise the 14-3-3-dependent ADP-ribosyltransferase domain662234
ExoSPseudomonas aeruginosa-bifunctional type-III cytotoxin with an N-terminal RhoGAP domain and and C-terminal ADP-ribosylation domain663377
ExoTPseudomonas aeruginosa--661784, 662150, 676823
ExoTPseudomonas aeruginosa-enzyme is comprised of an N-terminal domain with GTPase activating protein activity towards Rho family GTPases and a C-terminal ADP ribosyl-transferase (ADPRT) domain with minimal activity towards a synthetic substrate in vitro661878
ExoTPseudomonas aeruginosa-bifunctional type-III cytotoxin with an N-terminal RhoGAP domain and and C-terminal ADP-ribosylation domain663377
i-toxinClostridium perfringens--657492
ModAEnterobacteria phage T4P12726-659054
ModBEnterobacteria phage T4P12726-659054
msPARP ----
NAD(+) ADP-ribosyltransferase ----
NAD+:ADP-ribosyltransferase (polymerizing)----
NAD-dependent ADP-ribosyltransferaseTrypanosoma brucei--658546
NAD-protein ADP-ribosyltransferase----
NarENeisseria meningitidis--659962
pADPRT----
PAR polymeraseDrosophila melanogaster, Mus musculus--673854
PARPMus musculus--672801, 673854
PARPHomo sapiensO95271, P09874, Q2NL67, Q460N5, Q8N5Y8, Q9NR21, Q9UGN5, Q9UKK3, Q9Y6F1-672801
PARPDrosophila melanogaster--673854
PARP ----
PARP-1Gallus gallus--659706
PARP-1Mus musculus--671255, 672809, 672969, 675022, 675025, 676203
PARP-1Homo sapiens--671265, 675533
PARP-1Bos taurus--675627
PARP-related/IalphaI-related H5/proline-rich ----
PARPssSulfolobus solfataricus--678019
PH5P ----
poly (ADP-ribose) polymerase-1Homo sapiens--675533
poly(ADP-ribose) polymerase----
poly(ADP-ribose) polymeraseMus musculus--672809, 672969
poly(ADP-ribose) polymerase-1Homo sapiens--659466, 671265
poly(ADP-ribose) polymerase-1Gallus gallus--659706
poly(ADP-ribose) polymerase-1Mus musculus--671255, 675022, 676203
poly(ADP-ribose) polymerase-1Bos taurus--675627
poly(ADP-ribose) polymerase-like enzymeSulfolobus solfataricus--678019
poly(ADP-ribose) synthase----
poly(ADP-ribose) transferase----
poly(ADP-ribosyl)transferase----
poly[ADP-ribose] synthetase ----
TANK1Homo sapiensO95271, P09874, Q2NL67, Q460N5, Q8N5Y8, Q9NR21, Q9UGN5, Q9UKK3, Q9Y6F1-672801
TANK1 ----
TANK2 ----
tankyrase IHomo sapiensO95271, P09874, Q2NL67, Q460N5, Q8N5Y8, Q9NR21, Q9UGN5, Q9UKK3, Q9Y6F1-672801
Tankyrase-like protein ----
Tankyrase-related protein ----
TbSIR2RP1Trypanosoma brucei--658546
TNKS-1Homo sapiensO95271, P09874, Q2NL67, Q460N5, Q8N5Y8, Q9NR21, Q9UGN5, Q9UKK3, Q9Y6F1-672801
TRF1-interacting ankyrin-related ADP-ribose polymeraseHomo sapiensO95271, P09874, Q2NL67, Q460N5, Q8N5Y8, Q9NR21, Q9UGN5, Q9UKK3, Q9Y6F1-672801
TRF1-interacting ankyrin-related ADP-ribose polymerase ----
TTS-ExoSPseudomonas aeruginosa--672150
type III-secreted toxinPseudomonas aeruginosa--676823
VPARP ----
mono-ADP-ribosyltransferaseMus musculus--659225
additional informationHomo sapiensO95271, P09874, Q2NL67, Q460N5, Q8N5Y8, Q9NR21, Q9UGN5, Q9UKK3, Q9Y6F1the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs; the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs; the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs; the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs; the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs; the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs; the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs; the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs; the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs672801
additional informationMus musculus-the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs672801

CAS REGISTRY NUMBERCOMMENTARY
58319-92-9-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Bacillus cereusstrain 2339658013--Manually annotated by BRENDA team
Bacillus cereus 2339strain 2339658013--Manually annotated by BRENDA team
Bos taurus-637997, 637999, 675627--Manually annotated by BRENDA team
Bos tauruscalf638001--Manually annotated by BRENDA team
Clostridium botulinumtype c637994--Manually annotated by BRENDA team
Clostridium limosum-672048--Manually annotated by BRENDA team
Clostridium perfringens-657492--Manually annotated by BRENDA team
Cryptothecodinium cohnii-637998--Manually annotated by BRENDA team
Dictyostelium discoideum-637993--Manually annotated by BRENDA team
Drosophila melanogaster-673854--Manually annotated by BRENDA team
Enterobacteria phage T4ModA; ModB659054P12726UniprotManually annotated by BRENDA team
Enterobacteria phage T4 ModAModA659054P12726-Manually annotated by BRENDA team
Enterobacteria phage T4 ModBModB659054P12726-Manually annotated by BRENDA team
Gallus gallus-659706--Manually annotated by BRENDA team
Helix pomatia-637992--Manually annotated by BRENDA team
Homo sapiens-637991, 637996, 638000, 659466, 671265--Manually annotated by BRENDA team
Homo sapienshealthy people and Parkinson patients675533--Manually annotated by BRENDA team
Homo sapiensPARP-1672801P09874SwissProtManually annotated by BRENDA team
Homo sapiensPARP-11672801Q9NR21SwissProtManually annotated by BRENDA team
Homo sapiensPARP-14672801Q460N5SwissProtManually annotated by BRENDA team
Homo sapiensPARP-16672801Q8N5Y8SwissProtManually annotated by BRENDA team
Homo sapiensPARP-2672801Q9UGN5SwissProtManually annotated by BRENDA team
Homo sapiensPARP-3672801Q9Y6F1SwissProtManually annotated by BRENDA team
Homo sapiensPARP-4672801Q9UKK3SwissProtManually annotated by BRENDA team
Homo sapiensPARP-6672801Q2NL67SwissProtManually annotated by BRENDA team
Homo sapiensTNKS1672801O95271SwissProtManually annotated by BRENDA team
Mesocricetus auratus-637995--Manually annotated by BRENDA team
Mus musculus-658344, 659225, 671826, 672801, 672809, 672969, 676203--Manually annotated by BRENDA team
Mus musculusgene parp-1675025--Manually annotated by BRENDA team
Mus musculusisozymes PARP-1 and PARP-2673854--Manually annotated by BRENDA team
Mus musculusstrain 129/Sv x C57BL/6, female mice675022--Manually annotated by BRENDA team
Mus musculusSv129 mice671255--Manually annotated by BRENDA team
Mus musculus 129/Sv x C57BL/6strain 129/Sv x C57BL/6, female mice675022--Manually annotated by BRENDA team
Neisseria meningitidis-659962--Manually annotated by BRENDA team
Pseudomonas aeruginosa-660848, 660947, 661051, 661055, 661784, 661865, 661866, 661868, 661870, 661871, 661872, 661873, 661874, 661876, 661877, 661878, 661903, 662087, 662089, 662103, 662150, 662234, 662888, 662890, 663287, 672996, 676823--Manually annotated by BRENDA team
Pseudomonas aeruginosa388661867--Manually annotated by BRENDA team
Pseudomonas aeruginosaExo53 form of exoenzyme S; ExoS form of exoenzyme S661986--Manually annotated by BRENDA team
Pseudomonas aeruginosaExoS661065--Manually annotated by BRENDA team
Pseudomonas aeruginosaExoS; ExoT663377--Manually annotated by BRENDA team
Pseudomonas aeruginosagene exoS673573--Manually annotated by BRENDA team
Pseudomonas aeruginosastrain 388672150--Manually annotated by BRENDA team
Pseudomonas aeruginosastrain PA103695219--Manually annotated by BRENDA team
Pseudomonas aeruginosastrains PAK and PA14694800--Manually annotated by BRENDA team
Pseudomonas aeruginosa 388388661867--Manually annotated by BRENDA team
Pseudomonas aeruginosa ExoSExoS661065--Manually annotated by BRENDA team
Pseudomonas aeruginosa ExoTExoT663377--Manually annotated by BRENDA team
Rattus norvegicusrecombinant enzyme657940--Manually annotated by BRENDA team
Sulfolobus solfataricus-678019--Manually annotated by BRENDA team
Trypanosoma brucei-658546--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
NAD+ + (ADP-D-ribosyl)n-(EF-2)nicotinamide + (ADP-D-ribosyl)n+1-(EF-2)
show the reaction diagram		Pseudomonas aeruginosa-in native conformation, CRM66 shows limited ability to modify EF-2 covalently. Upon activation with urea and dithiothreitol CRM66 loses ADP-ribosylation activity entirely, yet it retains the ability to bind NAD+. Replacement of Tyr-426 with histidine in CRM66 completely restores cytotoxicity and ADP-ribosyltransferase activity662087--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Mus musculus--672801, 672969, 676203--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Bos taurus--637997, 638001--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa--660947, 661871, 662089, 672996, 673573, 676823--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Mesocricetus auratus--637995--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Sulfolobus solfataricus--678019--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Clostridium limosum--672048--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Homo sapiensO95271, P09874, Q2NL67, Q460N5, Q8N5Y8, Q9NR21, Q9UGN5, Q9UKK3, Q9Y6F1-672801--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Homo sapiens-poly(ADP-ribosyl)ation of topoisomerase I637996--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Homo sapiens-auto-poly(ADP-ribosyl)ation638000--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Homo sapiens-poly(ADP-ribosyl)ation of high mobility group proteins, poly(ADP-ribosyl)ation of DNA ligase, poly(ADP-ribosyl)ation of endonuclease, poly(ADP-ribosyl)ation of topoisomerase II, poly(ADP-ribosyl)ation of terminal deoxynucleotidyltransferase637996--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Clostridium botulinum-poly(ADP-ribosyl)ation of 21000-24000 Da platelet membrane proteins637994--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Homo sapiens-poly(ADP-ribosyl)ation of histone H1637991--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Bos taurus-poly(ADP-ribosyl)ation of histone H1637999--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Dictyostelium discoideum-poly(ADP-ribosyl)ation of histone H1637993--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Homo sapiens-poly(ADP-ribosyl)ation of histone637996--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Helix pomatia-poly(ADP-ribosyl)ation of histone637992--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Cryptothecodinium cohnii-poly(ADP-ribosyl)ation of histone637998--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Homo sapiens-catalyzes poly(ADP-ribosyl)ation of the synthetase itself, automodification637991--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Homo sapiens-poly(ADP-ribosyl)ation of ADP-ribosyltransferase637996--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-ADPRT domain of ExoT is active in vivo and contributes to the pathogenesis of Pseudomonas aeruginosa infections661878--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-exoenzyme S is an ADP-ribosyltransferase produced and directly translocated into eukaryotic cells by the opportunistic pathogen Pseudomonas aeruginosa. Factors expressed by growing epithelial cells are required for the bacterial contact-dependent translocation of ExoS. As normal epithelial cells differentiate into polarized confluent monolayers, expression of these factors is altered, and cells in turn become more resistant to the effects of ExoS661873--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-ExoS can modify multiple GTPases of the Ras superfamily in vivo. ExoS modulates the activity of several of GTP-binding proteins, such as Ras, Rap1, Rap2, Ral, Rac1, RhoA and Cdc42. It is suggested that ExoS is the major ADP-ribosyltransferase protein modulating small GTPase function encoded by Pseudomonas aeruginosa660947--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-ExoT modifies and inactivates host cell proteins involved in maintaining the actin cytoskeleton in vivo by two independent mechanisms. ADP-ribosylation activity of ExoT induces an irreversible disruption of actin microfilaments of infected Hela cells661784--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-intracellular expression of the amino terminus of ExoS in eukaryotic cells stimulates actin reorganization without cytotoxicity, which involves small-molecular-weight GTPases of the Rho subfamily661903--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-intracellular Ras is modified by bacterially translocated ExoS, inhibition of target cell proliferation correlates with the efficiency of Ras modification661871--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-ExoS has polysubstrate specificity and can ADP-ribosylate numerous host proteins, e.g. monomeric GTPase or vimentin. ExoS also undergoes auto-ADP-ribosylation. Ras has multiple alternative sites for ADP-ribosylation663377--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-ExoS is a type III cytotoxin which modulates two eukaryotic signalling pathways. The N-terminus (residues 1-234) is a GTPase activating protein for RhoGTPases, while the C-terminus (residues 232-453) encodes an ADP-ribosyltransferase662888--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-ExoT ADP-ribosylates a restricted subset of host proteins including the Crk proteins663377--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Drosophila melanogaster, Mus musculus-poly(ADP-ribosyl)ation, i.e. PARylation, plays diverse roles in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, cell death pathways, insulator function, and mitotic apparatus function, connections between nuclear NAD+ metabolism and nuclear signaling through PARP-1, physiologic functions, detailed overview, synthesis and degradation of PAR on an acceptor protein, pathway overview, the enzyme is involved in regulation of the steady-state levels of PAR673854--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Bos taurus-the enzyme is a DNA repair enzyme675627--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Drosophila melanogaster-linking a long negatively charged polymer to a protein, PARP catalyzes the polymerization of ADP-ribose units from donor NAD+ molecules on target proteins, resulting in the attachment of PAR, each residue in PAR contains an adenine moiety capable of base stacking and hydrogen bonding, as well as two phosphate groups that carry negative charges, substrate structure, overview673854--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Mus musculus-linking a long negatively charged polymer to a protein, PARP-1 catalyzes the polymerization of ADP-ribose units from donor NAD+ molecules on target proteins, resulting in the attachment of PAR, each residue in PAR contains an adenine moiety capable of base stacking and hydrogen bonding, as well as two phosphate groups that carry negative charges, substrate structure, overview673854--?
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
show the reaction diagram		Pseudomonas aeruginosa--694800, 695219--?
NAD+ + (ADP-D-ribosyl)n-apolipoproteinnicotinamide + (ADP-D-ribosyl)n+1-apolipoprotein
show the reaction diagram		Pseudomonas aeruginosa--661870--?
NAD+ + (ADP-D-ribosyl)n-Crk-Inicotinamide + (ADP-D-ribosyl)n+1-Crk-I
show the reaction diagram		Pseudomonas aeruginosa--662150--?
NAD+ + (ADP-D-ribosyl)n-Crk-IInicotinamide + (ADP-D-ribosyl)n+1-Crk-II
show the reaction diagram		Pseudomonas aeruginosa--662150--?
NAD+ + (ADP-D-ribosyl)n-His6HRasnicotinamide + (ADP-D-ribosyl)n+1-His6HRas
show the reaction diagram		Pseudomonas aeruginosa-the enzyme preferentially ADP-ribosylates membrane-associated His6HRas relative to its cytosolic His6HRasDELTACAAX with a C-terminal deletion661876--?
NAD+ + (ADP-D-ribosyl)n-immunoglobulin Anicotinamide + (ADP-D-ribosyl)n+1-immunoglobulin A
show the reaction diagram		Pseudomonas aeruginosa--661870--?
NAD+ + (ADP-D-ribosyl)n-immunoglobulin Gnicotinamide + (ADP-D-ribosyl)n+1-immunoglobulin G
show the reaction diagram		Pseudomonas aeruginosa-preferentially IgG3661870--?
NAD+ + (ADP-D-ribosyl)n-p21rasnicotinamide + (ADP-D-ribosyl)n+1-p21ras
show the reaction diagram		Pseudomonas aeruginosa-ADP-ribosylation of p21ras does not alter interactions with guanidine nucleotides. Possible function of the enzyme in pathogenesis661866--?
NAD+ + (ADP-D-ribosyl)n-Rab2nicotinamide + (ADP-D-ribosyl)n+1-Rab2
show the reaction diagram		Pseudomonas aeruginosa--661866--?
NAD+ + (ADP-D-ribosyl)n-Rab3nicotinamide + (ADP-D-ribosyl)n+1-Rab3
show the reaction diagram		Pseudomonas aeruginosa--661866--?
NAD+ + (ADP-D-ribosyl)n-rab4nicotinamide + (ADP-D-ribosyl)n+1-rab4
show the reaction diagram		Pseudomonas aeruginosa--661866--?
NAD+ + (ADP-D-ribosyl)n-rab4nicotinamide + (ADP-D-ribosyl)n+1-rab4
show the reaction diagram		Pseudomonas aeruginosa-ADP-ribosylation affects Rab4 function in membrane recycling660848--?
NAD+ + (ADP-D-ribosyl)n-Rab5nicotinamide + (ADP-D-ribosyl)n+1-Rab5
show the reaction diagram		Pseudomonas aeruginosa-ADP-ribosylation of Rab5 by ExoS affects endocytosis. Interaction of Rab5 with endosome antigen 1 is markedly diminished after Rab5 ADP-ribosylation by ExoS661874--?
NAD+ + (ADP-D-ribosyl)n-RalAnicotinamide + (ADP-D-ribosyl)n+1-RalA
show the reaction diagram		Pseudomonas aeruginosa-ADP-ribosylation of RalA by ExoS interferes with RalA activation and binding to its downstream effector in J774A.1 macrophages and suggests the potential of ExoS ADPRT activity to interfere with filiopodium formation through the inactivation of RalA and downstream effects mediated through the exocyst complex661877--?
NAD+ + (ADP-D-ribosyl)n-Rap1Anicotinamide + (ADP-D-ribosyl)n+1-Rap1A
show the reaction diagram		Pseudomonas aeruginosa--661866--?
NAD+ + (ADP-D-ribosyl)n-Rasnicotinamide + (ADP-D-ribosyl)n+1-Ras
show the reaction diagram		Pseudomonas aeruginosa--661903, 662103--?
NAD+ + (ADP-D-ribosyl)n-Rasnicotinamide + (ADP-D-ribosyl)n+1-Ras
show the reaction diagram		Pseudomonas aeruginosa-ADP-ribosylation of Ras at Arg41 disrupts Ras-Cdc25 interactions, which inhibits the rate-limiting step in Ras signal transduction, the activation of Ras by its guanine nucleotide exchange factor662103--?
NAD+ + (ADP-D-ribosyl)n-Ras proteinnicotinamide + (ADP-D-ribosyl)n+1-Ras protein
show the reaction diagram		Pseudomonas aeruginosa--661986--?
NAD+ + (ADP-D-ribosyl)n-soybean trypsin inhibitornicotinamide + (ADP-D-ribosyl)n+1-soybean trypsin inhibitor
show the reaction diagram		Pseudomonas aeruginosa--661986--?
NAD+ + (ADP-D-ribosyl)n-soybean-trypsin-inhibitornicotinamide + (ADP-D-ribosyl)n+1-soybean-trypsin-inhibitor
show the reaction diagram		Pseudomonas aeruginosa--661051, 661868--?
NAD+ + cyclophilin Anicotinamide + (ADP-D-ribosyl)-cyclophilin A
show the reaction diagram		Pseudomonas aeruginosa-cytosolic protein of several human epithelial cells, modification at Arg55 and Arg69 of cyclophilin A, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, overview, a non-G-protein substrate with peptidyl-prolyl isomerase activity, from several human epithelial cells, modification at Arg55 and Arg69, but not at Arg148, of cyclophilin A, i.e. CpA, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, activity with CpA mutants, overview672150--?
NAD+ + GTPase RhoAnicotinamide + (ADP-D-ribosyl)-GTPase RhoA
show the reaction diagram		Clostridium limosum-the exoenzyme modifies the low-molecular-mass GTPases RhoA, B, and C specifically at Asn41672048--?
NAD+ + GTPase RhoBnicotinamide + (ADP-D-ribosyl)-GTPase RhoB
show the reaction diagram		Clostridium limosum-the exoenzyme modifies the low-molecular-mass GTPases RhoA, B, and C specifically at Asn41672048--?
NAD+ + GTPase RhoCnicotinamide + (ADP-D-ribosyl)-GTPase RhoC
show the reaction diagram		Clostridium limosum-the exoenzyme modifies the low-molecular-mass GTPases RhoA, B, and C specifically at Asn41672048--?
NAD+ + H2Onicotinamide + ADP-ribose
show the reaction diagram		Rattus norvegicus--657940--?
NAD+ + histone H1nicotinamide + (ADP-D-ribosyl)-histone H1
show the reaction diagram		Homo sapiens--659466--?
NAD+ + histone H2Anicotinamide + (ADP-D-ribosyl)-histone H2A
show the reaction diagram		Trypanosoma brucei-the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair, the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B658546--?
NAD+ + histone H2Bnicotinamide + (ADP-D-ribosyl)-histone H2B
show the reaction diagram		Bos taurus--675627--?
NAD+ + histone H2Bnicotinamide + (ADP-D-ribosyl)-histone H2B
show the reaction diagram		Trypanosoma brucei-the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair, the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B658546--?
NAD+ + lymphocyte function-associated antigen LFA-1nicotinamide + ?
show the reaction diagram		Mus musculus--658344--?
NAD+ + moesinnicotinamide + (ADP-D-ribosyl)-moesin
show the reaction diagram		Pseudomonas aeruginosa-ADP-ribosylated-moesin is a poor target for phosphorylation by protein kinase C and Rho kinase, which shows that ADP-ribosylation directly inhibits ERM phosphorylation, modification of Arg553, Arg560 and Arg563, activity with wild-type and mutant moesins, overview672996--?
NAD+ + non-muscle actin from human plateletsnicotinamide + (ADP-D-ribosyl)-non-muscle actin from human platelets
show the reaction diagram		Clostridium perfringens--657492--?
NAD+ + p53nicotinamide + (ADP-D-ribosyl)-p53
show the reaction diagram		Mus musculus-PARP-1 interacts with and poly(ADP-ribosyl)ates p53, which participates in DNA recombination676203--?
NAD+ + poly(ADP-ribose) polymerase-1nicotinamide + (ADP-ribosyl)-poly(ADP-ribose) polymerase-1
show the reaction diagram		Gallus gallus-the 40 kDa CD fragment of avian PARP-1 efficiently catalyzes a covalent auto-poly-(ADP-ribosyl)ation reaction via an intermolecular mechanism that is completely independent of DNA659706--?
NAD+ + Rab5 proteinnicotinamide + (ADP-D-ribosyl)-Rab5 protein + H+
show the reaction diagram		Pseudomonas aeruginosa-Rab5 mediates entry of the EGFR into early endosomes695219--?
NAD+ + Rab9 proteinnicotinamide + (ADP-D-ribosyl)-Rab9 protein + H+
show the reaction diagram		Pseudomonas aeruginosa--695219--?
NAD+ + rabbit muscle actinnicotinamide + (ADP-D-ribosyl)-rabbit muscle actin
show the reaction diagram		Clostridium perfringens--657492--?
NAD+ + Rasnicotinamide + (ADP-D-ribosyl)-Ras
show the reaction diagram		Pseudomonas aeruginosa-interaction requires residue Leu428673573--?
NAD+ + Ras GTPasenicotinamide + (ADP-D-ribosyl)-Ras GTPase
show the reaction diagram		Pseudomonas aeruginosa--672996--?
NAD+ + Ras2pnicotinamide + (ADP-D-ribosyl)-Ras2p + H+
show the reaction diagram		Pseudomonas aeruginosa-Ras2p is a yeast protein, activity absolutely requires the yeast protein Bmh1p694800--?
NAD+ + RhoAnicotinamide (ADP-D-ribosyl)-RhoA
show the reaction diagram		Bacillus cereus--658013--?
NAD+ + RhoBnicotinamide (ADP-D-ribosyl)-RhoB
show the reaction diagram		Bacillus cereus--658013--?
NAD+ + RhoCnicotinamide (ADP-D-ribosyl)-RhoC
show the reaction diagram		Bacillus cereus-weak activity658013--?
NAD+ + RNA polymerasenicotinamide + (ADP-D-ribosyl)-RNA polymerase
show the reaction diagram		Enterobacteria phage T4P12726three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control659054--?
NAD+ + soybean trypsin inhibitornicotinamide + (ADP-D-ribosyl)-soybean trypsin inhibitor
show the reaction diagram		Clostridium limosum-the exoenzyme modifies the substrate at an arginine residue672048--?
NAD+ + topoisomerase Inicotinamide + (ADP-D-ribosyl)-topoisomerase I
show the reaction diagram		Mus musculus-PARP-1 interacts with and poly(ADP-ribosyl)ates topoisomerase I, which participates in DNA recombination, I-SceI-meganuclease-mediated cleavage terminates the interaction, overview676203--?
NAD+ + vimentinnicotinamide + (ADP-D-ribosyl)-vimentin
show the reaction diagram		Pseudomonas aeruginosa--672996--?
NAD+ + wild-type exoenzyme C3nicotinamide + (ADP-D-ribosyl)-wild-type exoenzyme C3
show the reaction diagram		Clostridium limosum-activity of the recombinant mutant Q217E exoenzyme C3, modification at Arg86672048--?
integrin alpha7 + NAD+(ADP-D-ribosyl)-integrin alpha7 + nicotinamide
show the reaction diagram		Mus musculus-the extracellular domain of integrin alpha7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD+ to intact C2C12 muscle cells, integrin alpha7 N-terminal ADP-ribosylation inhibits the binding of integrin alpha7beta1 to laminin activation status of integrin alpha7beta1 in intact myotubes, overview, the extracellular domain of integrin alpha7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD+ to intact C2C12 muscle cells, integrin alpha7 ADP-ribosylation inhibits the binding of integrin alpha7beta1 to laminin, binding site, overview671826--?
additional information?-Homo sapiens-ADP-ribosylation seems to be involved in regulation of differentiation, the enzyme may be centrally involved in tumorigenic cell transformation, the enzyme appears to be a central controller of cell processes: higher activities shift the cell towards proliferation, low activities shift the cell towards differentiation, role of the enzyme in DNA repair637996---
additional information?-Bos taurus-cuts produced in vivo on DNA during DNA repair activate the enzyme, which then synthesiszes poly(ADP-ribose) on histone H1, in particular, and contributes to the opening of the 25 nm chromatin fiber, resulting in the increased accessibility of DNA to excision repair enzymes637999---
additional information?-Clostridium botulinum-the enzyme modifies eukaryotic 21000-24000 Da GTP-binding proteins637994---
additional information?-Homo sapiens-role of the enzyme in DNA repair, the unmodified polymerase molecules bind tightly to DNA strand breaks: auto-poly(ADP-ribosyl)ation of the protein then effects its release and allows access to lesions for DNA repair enzymes638000---
additional information?-Homo sapiens-mechanistic basis for the physiological function of PARP-1 in the dynamics of the local modulation of chromatin structure. PARP-1 activation upon binding to base-unpaired regions and stem-loops structures in DNA leads to a local PAR modification of histones and non-histone proteins at genomic sites where such DNA structures are formed. Subsequent PARP-1 automodification results in its dissociation from DNA leading to an enzymatic self-inactivation thus ensuring a transient character of chromatin ADP-ribosylation. In combination with the PAR-glycohydrolase degradation of ADP-ribose polymers on acceptor proteins, PARP-1 interaction with DNA secondary structures provides a mechanism for local and transient chromatin modification by PAR during physiological nuclear processes659466---
additional information?-Mus musculus-raft association focuses ART2.2 on specific targets that constitutively or inducibly assoiate with lipid rafts658344---
additional information?-Mus musculus-ART1 is an arginine-specific transferase659225---
additional information?-Neisseria meningitidis-narE possesses ADP-ribosylating and NAD-glycohydrolase activities659962---
additional information?-Pseudomonas aeruginosa-exoenzyme S and 14-3-3 interact in a direct fashion, interaction involves the conserved amphiphatic groove of 14-3-3661055---
additional information?-Pseudomonas aeruginosa-exoenzyme S is an important adhesin661865---
additional information?-Pseudomonas aeruginosa-ExoS is a virulence factor of the pathogen672996---
additional information?-Homo sapiens-PARP-1 inhibits the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP. Inhibition of TonEBP/OREBP transcriptional activity by PARP-1 does not require PARP-1 catalytic activity, functional interaction anaylsis, overview671265---
additional information?-Mus musculus-PARP-1 is involved in modulation of NO-derived injury and response to genotoxic damage675025---
additional information?-Mus musculus-PARP-1 plays an essential role in the control of cell repair and tissue remodeling after hyperoxia-induced lung injury, overview671255---
additional information?-Mus musculus-PARP-1 plays fundamental roles in the recruitment and modulation of enzymatic and regulatory factors involved in transcription, DNA replication, repair and recombination, the enzyme antagonizes topoisomerase I-dependent recombination stimulation by P53676203---
additional information?-Mus musculus-PARP-1 responds to DNA damage by transferring 50 to 200 molecules of ADP-ribose to various nuclear proteins, including transcription factors, histones and PARP-1 itself, interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition, ATM and PARP-1 are two of the most important players in the cell's response to DNA damage, PARP-1 is needed for optimal activation of ATM, overview672809---
additional information?-Pseudomonas aeruginosa-Pseudomonas aeruginosa inhibits mammalian cytokinesis in a type III secretion system and exotoxin T-dependent manner, the ADP-ribosyl transferase domain inhibits late steps of cytokinesis by blocking syntaxin-2 localization to the midbody, an event essential for completion of cytokinesis, e.g. in Madin-Darby canine kidney cells, mechanism, overview676823---
additional information?-Mus musculus-role for PARP-1 in DNA double-strand break repair, the enzyme is not required for homologous recombination itself, it regulates the process through its involvement in the repair of DNA single-strand breaks, PARP-1 binds to DNA breaks to facilitate DNA repair, but the role of PARP-1 in DNA repair appears to not be critical since PARP-1 knockout mice are viable, fertile and do not develop early onset tumors, DNA binding and auto-modification of PARP-1 attracts the DNA repair proteins672969---
additional information?-Pseudomonas aeruginosa-the bacterial enzyme shows the ability to mediate cell death in the host and is a toxin, residues 426-428 are required for this activity673573---
additional information?-Mus musculus-the enzyme is involved in endothelial cell dysfunction675022---
additional information?-Homo sapiens-the enzyme is involved in pathogenesis of Parkinson's disease, analysis of polymorphisms, overview675533---
additional information?-Drosophila melanogaster, Mus musculus-transcriptional regulation mechanism, overview673854---
additional information?-Pseudomonas aeruginosa-exoenzyme S is a bifunctional type III secretion, TTS, effector protein, with GTPase-activating and ADP-ribosyltransferase activities672150---
additional information?-Pseudomonas aeruginosa-ExoS is a bifunctional toxin with an N-terminal Rho GTPase activating protein, GAP, domain, and a C-terminal ADP-ribosyltransferase domain which transfers ADP-ribose from NAD onto substrates such as the Ras GTPases and vimentin672996---
additional information?-Pseudomonas aeruginosa-ExoT is a bifunctional type III secretion system effector protein that contains an N-terminal GTPase-activating protein domain and a C-terminal ADP-ribosyl transferase domain676823---
additional information?-Mus musculus-PARP-1 protein has an N-terminal DNA binding domain containing two large zinc fingers that bind to both DNA single-strand breaks and DNA double-strand breaks, DNA binding by PARP-1 triggers its activity and it adds poly(ADP-ribose) polymers to itself and to surrounding histones, overview672969---
additional information?-Clostridium limosum-the enzyme also shows NAD+-hydrolase activity672048---
additional information?-Homo sapiens-the enzyme shows DNA-binding activity, and is physically associated with the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP671265---
additional information?-Pseudomonas aeruginosa-ExoS is a toxin playing a pivotal role during Pseudomonas aeruginosa infections, it is a virulence factor causing growth inhibition in Saccharomyces cerevisiae. Exoenzyme S ADP-ribosylates identical targets in both human and yeast694800---
additional information?-Pseudomonas aeruginosa-ExoS is a type III cytotoxin, that ADP-ribosylates Rab GTPases to inhibit host cell vesicle trafficking pathways by modulating HeLa host cell endocytosis, wild-type ExoS uncouples Rab5-early endosome antigen 1 interaction and inhibits fluid phase uptake, as well as Pseudomonas aeruginosa internalization, RhoGAP, but not ADPr, the ADPr domain is dispensable for anti-internalization function, but is required for inhibition of EGF-activated EGFR degradation in HeLa cells, mechanism, overview, ExoS is a bi-functional type III cytotoxin that possesses Rho GTPase activating protein and ADP-ribosyltransferase activities, no activity with Rab4 protein, overview695219---

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Mus musculus--672801, 672969, 676203--
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa--672996, 673573, 676823--
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Clostridium limosum--672048--
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Homo sapiensO95271, P09874, Q2NL67, Q460N5, Q8N5Y8, Q9NR21, Q9UGN5, Q9UKK3, Q9Y6F1-672801--
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-ADPRT domain of ExoT is active in vivo and contributes to the pathogenesis of Pseudomonas aeruginosa infections661878--
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-exoenzyme S is an ADP-ribosyltransferase produced and directly translocated into eukaryotic cells by the opportunistic pathogen Pseudomonas aeruginosa. Factors expressed by growing epithelial cells are required for the bacterial contact-dependent translocation of ExoS. As normal epithelial cells differentiate into polarized confluent monolayers, expression of these factors is altered, and cells in turn become more resistant to the effects of ExoS661873--
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-ExoS can modify multiple GTPases of the Ras superfamily in vivo. ExoS modulates the activity of several of GTP-binding proteins, such as Ras, Rap1, Rap2, Ral, Rac1, RhoA and Cdc42. It is suggested that ExoS is the major ADP-ribosyltransferase protein modulating small GTPase function encoded by Pseudomonas aeruginosa660947--
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-ExoT modifies and inactivates host cell proteins involved in maintaining the actin cytoskeleton in vivo by two independent mechanisms. ADP-ribosylation activity of ExoT induces an irreversible disruption of actin microfilaments of infected Hela cells661784--
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-intracellular expression of the amino terminus of ExoS in eukaryotic cells stimulates actin reorganization without cytotoxicity, which involves small-molecular-weight GTPases of the Rho subfamily661903--
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Pseudomonas aeruginosa-intracellular Ras is modified by bacterially translocated ExoS, inhibition of target cell proliferation correlates with the efficiency of Ras modification661871--
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Drosophila melanogaster, Mus musculus-poly(ADP-ribosyl)ation, i.e. PARylation, plays diverse roles in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, cell death pathways, insulator function, and mitotic apparatus function, connections between nuclear NAD+ metabolism and nuclear signaling through PARP-1, physiologic functions, detailed overview, synthesis and degradation of PAR on an acceptor protein, pathway overview, the enzyme is involved in regulation of the steady-state levels of PAR673854--
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram		Bos taurus-the enzyme is a DNA repair enzyme675627--
NAD+ + (ADP-D-ribosyl)n-acceptornicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
show the reaction diagram		Pseudomonas aeruginosa--694800, 695219--
NAD+ + (ADP-D-ribosyl)n-p21rasnicotinamide + (ADP-D-ribosyl)n+1-p21ras
show the reaction diagram		Pseudomonas aeruginosa-ADP-ribosylation of p21ras does not alter interactions with guanidine nucleotides. Possible function of the enzyme in pathogenesis661866--
NAD+ + (ADP-D-ribosyl)n-rab4nicotinamide + (ADP-D-ribosyl)n+1-rab4
show the reaction diagram		Pseudomonas aeruginosa-ADP-ribosylation affects Rab4 function in membrane recycling660848--
NAD+ + (ADP-D-ribosyl)n-Rab5nicotinamide + (ADP-D-ribosyl)n+1-Rab5
show the reaction diagram		Pseudomonas aeruginosa-ADP-ribosylation of Rab5 by ExoS affects endocytosis. Interaction of Rab5 with endosome antigen 1 is markedly diminished after Rab5 ADP-ribosylation by ExoS661874--
NAD+ + (ADP-D-ribosyl)n-RalAnicotinamide + (ADP-D-ribosyl)n+1-RalA
show the reaction diagram		Pseudomonas aeruginosa-ADP-ribosylation of RalA by ExoS interferes with RalA activation and binding to its downstream effector in J774A.1 macrophages and suggests the potential of ExoS ADPRT activity to interfere with filiopodium formation through the inactivation of RalA and downstream effects mediated through the exocyst complex661877--
NAD+ + (ADP-D-ribosyl)n-Rasnicotinamide + (ADP-D-ribosyl)n+1-Ras
show the reaction diagram		Pseudomonas aeruginosa-ADP-ribosylation of Ras at Arg41 disrupts Ras-Cdc25 interactions, which inhibits the rate-limiting step in Ras signal transduction, the activation of Ras by its guanine nucleotide exchange factor662103--
NAD+ + cyclophilin Anicotinamide + (ADP-D-ribosyl)-cyclophilin A
show the reaction diagram		Pseudomonas aeruginosa-cytosolic protein of several human epithelial cells, modification at Arg55 and Arg69 of cyclophilin A, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, overview672150--
NAD+ + histone H2Anicotinamide + (ADP-D-ribosyl)-histone H2A
show the reaction diagram		Trypanosoma brucei-the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair658546--
NAD+ + histone H2Bnicotinamide + (ADP-D-ribosyl)-histone H2B
show the reaction diagram		Trypanosoma brucei-the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair658546--
NAD+ + moesinnicotinamide + (ADP-D-ribosyl)-moesin
show the reaction diagram		Pseudomonas aeruginosa-ADP-ribosylated-moesin is a poor target for phosphorylation by protein kinase C and Rho kinase, which shows that ADP-ribosylation directly inhibits ERM phosphorylation672996--
NAD+ + p53nicotinamide + (ADP-D-ribosyl)-p53
show the reaction diagram		Mus musculus--676203--
NAD+ + Rab5 proteinnicotinamide + (ADP-D-ribosyl)-Rab5 protein + H+
show the reaction diagram		Pseudomonas aeruginosa-Rab5 mediates entry of the EGFR into early endosomes695219--
NAD+ + Rab9 proteinnicotinamide + (ADP-D-ribosyl)-Rab9 protein + H+
show the reaction diagram		Pseudomonas aeruginosa--695219--
NAD+ + Rasnicotinamide + (ADP-D-ribosyl)-Ras
show the reaction diagram		Pseudomonas aeruginosa-interaction requires residue Leu428673573--
NAD+ + Ras GTPasenicotinamide + (ADP-D-ribosyl)-Ras GTPase
show the reaction diagram		Pseudomonas aeruginosa--672996--
NAD+ + RNA polymerasenicotinamide + (ADP-D-ribosyl)-RNA polymerase
show the reaction diagram		Enterobacteria phage T4P12726three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control659054--
NAD+ + topoisomerase Inicotinamide + (ADP-D-ribosyl)-topoisomerase I
show the reaction diagram		Mus musculus--676203--
NAD+ + vimentinnicotinamide + (ADP-D-ribosyl)-vimentin
show the reaction diagram		Pseudomonas aeruginosa--672996--
integrin alpha7 + NAD+(ADP-D-ribosyl)-integrin alpha7 + nicotinamide
show the reaction diagram		Mus musculus-the extracellular domain of integrin alpha7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD+ to intact C2C12 muscle cells, integrin alpha7 N-terminal ADP-ribosylation inhibits the binding of integrin alpha7beta1 to laminin activation status of integrin alpha7beta1 in intact myotubes, overview671826--
additional information?-Homo sapiens-ADP-ribosylation seems to be involved in regulation of differentiation, the enzyme may be centrally involved in tumorigenic cell transformation, the enzyme appears to be a central controller of cell processes: higher activities shift the cell towards proliferation, low activities shift the cell towards differentiation, role of the enzyme in DNA repair637996--
additional information?-Bos taurus-cuts produced in vivo on DNA during DNA repair activate the enzyme, which then synthesiszes poly(ADP-ribose) on histone H1, in particular, and contributes to the opening of the 25 nm chromatin fiber, resulting in the increased accessibility of DNA to excision repair enzymes637999--
additional information?-Clostridium botulinum-the enzyme modifies eukaryotic 21000-24000 Da GTP-binding proteins637994--
additional information?-Homo sapiens-role of the enzyme in DNA repair, the unmodified polymerase molecules bind tightly to DNA strand breaks: auto-poly(ADP-ribosyl)ation of the protein then effects its release and allows access to lesions for DNA repair enzymes638000--
additional information?-Homo sapiens-mechanistic basis for the physiological function of PARP-1 in the dynamics of the local modulation of chromatin structure. PARP-1 activation upon binding to base-unpaired regions and stem-loops structures in DNA leads to a local PAR modification of histones and non-histone proteins at genomic sites where such DNA structures are formed. Subsequent PARP-1 automodification results in its dissociation from DNA leading to an enzymatic self-inactivation thus ensuring a transient character of chromatin ADP-ribosylation. In combination with the PAR-glycohydrolase degradation of ADP-ribose polymers on acceptor proteins, PARP-1 interaction with DNA secondary structures provides a mechanism for local and transient chromatin modification by PAR during physiological nuclear processes659466--
additional information?-Mus musculus-raft association focuses ART2.2 on specific targets that constitutively or inducibly assoiate with lipid rafts658344--
additional information?-Pseudomonas aeruginosa-exoenzyme S and 14-3-3 interact in a direct fashion, interaction involves the conserved amphiphatic groove of 14-3-3661055--
additional information?-Pseudomonas aeruginosa-exoenzyme S is an important adhesin661865--
additional information?-Pseudomonas aeruginosa-ExoS is a virulence factor of the pathogen672996--
additional information?-Homo sapiens-PARP-1 inhibits the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP. Inhibition of TonEBP/OREBP transcriptional activity by PARP-1 does not require PARP-1 catalytic activity, functional interaction anaylsis, overview671265--
additional information?-Mus musculus-PARP-1 is involved in modulation of NO-derived injury and response to genotoxic damage675025--
additional information?-Mus musculus-PARP-1 plays an essential role in the control of cell repair and tissue remodeling after hyperoxia-induced lung injury, overview671255--
additional information?-Mus musculus-PARP-1 plays fundamental roles in the recruitment and modulation of enzymatic and regulatory factors involved in transcription, DNA replication, repair and recombination, the enzyme antagonizes topoisomerase I-dependent recombination stimulation by P53676203--
additional information?-Mus musculus-PARP-1 responds to DNA damage by transferring 50 to 200 molecules of ADP-ribose to various nuclear proteins, including transcription factors, histones and PARP-1 itself, interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition, ATM and PARP-1 are two of the most important players in the cell's response to DNA damage, PARP-1 is needed for optimal activation of ATM, overview672809--
additional information?-Pseudomonas aeruginosa-Pseudomonas aeruginosa inhibits mammalian cytokinesis in a type III secretion system and exotoxin T-dependent manner, the ADP-ribosyl transferase domain inhibits late steps of cytokinesis by blocking syntaxin-2 localization to the midbody, an event essential for completion of cytokinesis, e.g. in Madin-Darby canine kidney cells, mechanism, overview676823--
additional information?-Mus musculus-role for PARP-1 in DNA double-strand break repair, the enzyme is not required for homologous recombination itself, it regulates the process through its involvement in the repair of DNA single-strand breaks, PARP-1 binds to DNA breaks to facilitate DNA repair, but the role of PARP-1 in DNA repair appears to not be critical since PARP-1 knockout mice are viable, fertile and do not develop early onset tumors, DNA binding and auto-modification of PARP-1 attracts the DNA repair proteins672969--
additional information?-Pseudomonas aeruginosa-the bacterial enzyme shows the ability to mediate cell death in the host and is a toxin, residues 426-428 are required for this activity673573--
additional information?-Mus musculus-the enzyme is involved in endothelial cell dysfunction675022--
additional information?-Homo sapiens-the enzyme is involved in pathogenesis of Parkinson's disease, analysis of polymorphisms, overview675533--
additional information?-Drosophila melanogaster, Mus musculus-transcriptional regulation mechanism, overview673854--
additional information?-Pseudomonas aeruginosa-ExoS is a toxin playing a pivotal role during Pseudomonas aeruginosa infections, it is a virulence factor causing growth inhibition in Saccharomyces cerevisiae. Exoenzyme S ADP-ribosylates identical targets in both human and yeast694800--
additional information?-Pseudomonas aeruginosa-ExoS is a type III cytotoxin, that ADP-ribosylates Rab GTPases to inhibit host cell vesicle trafficking pathways by modulating HeLa host cell endocytosis, wild-type ExoS uncouples Rab5-early endosome antigen 1 interaction and inhibits fluid phase uptake, as well as Pseudomonas aeruginosa internalization, RhoGAP, but not ADPr, the ADPr domain is dispensable for anti-internalization function, but is required for inhibition of EGF-activated EGFR degradation in HeLa cells, mechanism, overview695219--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
NAD+Pseudomonas aeruginosa--694800, 695219 2D-image
additional informationPseudomonas aeruginosa-Bmh1p, a yeast homologue of the human FAS, acts as an ExoS cofactor, overview694800-

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
Ba2+Homo sapiens-enhances activity637991
Mg2+Homo sapiens-enhances both the automodification and poly(ADP-ribosyl)ation of histone H1637991
Mg2+Mesocricetus auratus-divalent cation required, Mg2+ preferred to Mn2+, optimal concentration 5 mM637995
Mg2+Bos taurus-activates637997
Mg2+Clostridium limosum-required672048
Mg2+Bos taurus--675627
Mg2+Pseudomonas aeruginosa--694800, 695219
Mn2+Mesocricetus auratus-divalent cation required, Mg2+ preferred to Mn2+637995
Mn2+Mus musculus-required for activity, cannot be substituted by Mg2+671826
Sr2+Homo sapiens-enhances activity637991

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0469-0796Pseudomonas aeruginosa-restores yeast growth after treatment with ExoS694800 2D-image
1(2H)-phthalazinoneBos taurus-IC50: 0.012 mM637997 2D-image
1,2-benzopyroneBos taurus-IC50: 2.8 mM637997 2D-image
1,3-benzodiazineBos taurus-IC50: 2.0 mM637997 2D-image
1,3-dihydroxynaphthaleneBos taurus-IC50: 1.3 mM637997 2D-image
1,4-benzoquinoneBos taurus-IC50: 0.4 mM637997 2D-image
1,4-naphthalenedioneBos taurus-IC50: 0.25 mM637997 2D-image
1,5-dihydroxyisoquinolineBos taurus-IC50: 0.00039 mM637997 2D-image
1,8-naphthalimideBos taurus-IC50: 0.0014 mM637997 2D-image
1-hydroxy-2-methyl-4-aminonaphthaleneBos taurus-IC50: 1.3 mM637997 2D-image
1-hydroxyisoquinolineBos taurus-IC50: 0.007 mM637997 2D-image
1-IndanoneBos taurus-IC50: 0.81 mM637997 2D-image
1-methylnicotinamide chlorideBos taurus-IC50: 3.8 mM637997 2D-image
1-methylnicotinamide chlorideBos taurus-IC50: 1.7 mM638001 2D-image
2,3-benzodiazineBos taurus-IC50: 0.15 mM637997 2D-image
2,3-dichloro-1,4-naphthoquinoneBos taurus-IC50: 0.26 mM637997 2D-image
2,3-dihydro-1,4-phthalazinedioneBos taurus-IC50: 0.03 mM637997 2D-image
2,3-dihydro-5-hydroxy-1,4-phthalazinedioneDictyostelium discoideum-0.001 mM, 95% inhibition of the 116000 Da enzyme637993-
2,4(1H,3H)-quinazolinedioneBos taurus-IC50: 0.0081 mM637997 2D-image
2,6-difluorobenzamideBos taurus-IC50: 0.18 mM637997 2D-image
2-acetamidobenzamideBos taurus-IC50: 1.0 mM637997 2D-image
2-amino-3-chloro-1,4-naphthoquinoneBos taurus-IC50: 0.82 mM637997 2D-image
2-AminobenzamideBos taurus-IC50: 0.65 mM637997 2D-image
2-AminobenzamideBos taurus-IC50: 0.1 mM638001 2D-image
2-bromobenzamideBos taurus-IC50: 2.9 mM637997 2D-image
2-chlorobenzamideBos taurus-IC50: 1.0 mM637997 2D-image
2-fluorobenzamideBos taurus-IC50: 0.12 mM637997 2D-image
2-Hydroxy-1,4-naphthoquinoneBos taurus-IC50: 0.33 mM637997 2D-image
2-hydroxybenzamideBos taurus-IC50: 0.82 mM637997 2D-image
2-mercapto-4(3H)-quinazolinoneBos taurus-IC50: 0.044 mM637997 2D-image
2-MethoxybenzamideBos taurus-IC50: 0.2 mM637997 2D-image
2-methyl-1,4-benzopyroneBos taurus-IC50: 0.045 mM637997 2D-image
2-methyl-1,4-naphthoquinoneBos taurus-IC50: 0.42 mM637997 2D-image
2-methyl-3-phytyl-1,4-naphthoquinoneBos taurus-IC50: 0.52 mM637997 2D-image
2-methyl-4(3H)-quinazolinoneBos taurus-IC50: 0.056 mM637997 2D-image
2-methylbenzamideBos taurus-IC50: 1.5 mM637997 2D-image
2-methylchromoneBos taurus-IC50: 0.045 mM637997 2D-image
2-nitro-6(5H)-phenanthridioneBos taurus-IC50: 0.00035 mM637997 2D-image
2-phenylchromoneBos taurus-IC50: 0.022 mM637997 2D-image
2-trichloromethyl-4(3H)-quinazolinoneBos taurus-IC50: 2.2 mM637997 2D-image
2H-benz[c]isoquinolin-1-oneBos taurus-IC50: 0.0003 mM637997 2D-image
2H-benz[de]isoquinoline-1,3-dioneBos taurus-IC50: 0.0014 mM637997 2D-image
3,4-dihydro-1(2H)-naphthalenoneBos taurus-IC50: 0.31 mM637997 2D-image
3,5-dibromosalicylamideBos taurus-IC50: 0.56 mM637997 2D-image
3,5-dimethoxybenzamideBos taurus-IC50: 1.2 mM637997 2D-image
3,5-dinitrobenzamideBos taurus-IC50: 2.5 mM637997 2D-image
3-(N,N-dimethylamino)benzamideBos taurus-IC50: 0.12 mM637997 2D-image
3-AcetamidobenzamideBos taurus-IC50: 0.012 mM637997 2D-image
3-acetamidosalicylamideBos taurus-IC50: 2.0 mM637997 2D-image
3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indoleBos taurus-i.e. Trp-P-1, 94% inhibition at 5 mM, IC50: 0.22 mM675627 2D-image
3-amino-1-methyl-5H-pyrido[4,3-b]indoleBos taurus-i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM675627 2D-image
3-AminobenzamideHomo sapiens-1 mM, 99% inhibition637991 2D-image
3-AminobenzamideHelix pomatia-1 mM, 98% inhibition637992 2D-image
3-AminobenzamideDictyostelium discoideum--637993 2D-image
3-AminobenzamideBos taurus-IC50: 0.33 mM637997 2D-image
3-AminobenzamideBos taurus-IC50: 0.0054638001 2D-image
3-AminobenzamideHomo sapiens--671265 2D-image
3-AminobenzamideMus musculus--672809 2D-image
3-aminobenzoic acidHomo sapiens-1 mM, 12% inhibition637991 2D-image
3-AminophthalhydrazideDictyostelium discoideum-0.1 mM, 98% inhibition of the 116000 Da enzyme637993 2D-image
3-AminophthalhydrazideBos taurus-IC50: 0.023 mM637997 2D-image
3-bromobenzamideBos taurus-IC50: 0.055 mM637997 2D-image
3-ChlorobenzamideBos taurus-IC50: 0.22 mM637997 2D-image
3-FluorobenzamideBos taurus-IC50: 0.2 mM637997 2D-image
3-GuanidinobenzamideDictyostelium discoideum-0.1 mM, 71% inhibition of the 116000 Da enzyme637993 2D-image
3-HydroxybenzamideDictyostelium discoideum-0.1 mM, 89% inhibition of the 116000 Da enzyme637993 2D-image
3-HydroxybenzamideBos taurus-IC50: 0.0091 mM637997 2D-image
3-isobutyl-1-methylxanthineBos taurus-IC50: 3.1 mM638001 2D-image
3-MethoxybenzamideHelix pomatia-1 mM, 98% inhibition637992 2D-image
3-MethoxybenzamideDictyostelium discoideum-0.01 mM, 85% inhibition of the 116000 Da enzyme, 84% inhibition of the 90000 Da enzyme; 1 mM, 96% inhibition of the 116000 Da enzyme, 95% inhibition of the 90000 Da enzyme637993 2D-image
3-MethoxybenzamideBos taurus-IC50: 0.017 mM637997 2D-image
3-MethoxybenzamideBos taurus-IC50: 0.0034 mM638001 2D-image
3-MethylbenzamideBos taurus-IC50: 0.19 mM637997 2D-image
3-nitrobenzamideBos taurus-IC50: 0.16 mM637997 2D-image
3-nitrophthalhydrazideBos taurus-IC50: 0.072 mM637997 2D-image
3-nitrosalicylamideBos taurus-IC50: 1.6 mM637997 2D-image
4,8-dihydroxy-2-quinolinecarboxylic acidBos taurus-IC50: 0.19 mM637997 2D-image
4-amino-1,8-naphthalimideBos taurus-IC50: 0.00018 mM637997 2D-image
4-AminobenzamideBos taurus-IC50: 1.8 mM637997 2D-image
4-AminobenzamideBos taurus-IC50: 0.4 mM638001 2D-image
4-aminophthalhydrazideBos taurus-IC50: 0.29 mM637997 2D-image
4-bromobenzamideBos taurus-IC50: 2.2 mM637997 2D-image
4-chlorobenzamideBos taurus-IC50: 0.3 mM637997 2D-image
4-chromanoneBos taurus-IC50: 0.72 mM637997 2D-image
4-fluorobenzamideBos taurus-IC50: 0.2 mM637997 2D-image
4-hydroxy-2-methylquinolineBos taurus-IC50: 0.074 mM637997 2D-image
4-hydroxy-2-quinolinecarboxylic acidBos taurus-IC50: 0.67 mM637997 2D-image
4-hydroxybenzamideBos taurus-IC50: 0.28 mM637997 2D-image
4-HydroxycoumarinBos taurus-IC50: 0.57 mM637997 2D-image
4-hydroxypyridineBos taurus-IC50: 2.3 mM637997 2D-image
4-hydroxyquinazolineBos taurus-IC50: 0.0095 mM637997 2D-image
4-hydroxyquinolineBos taurus-IC50: 0.08 mM637997 2D-image
4-methoxybenzamideBos taurus-IC50: 1.1 mM637997 2D-image
4-methylbenzamideBos taurus-IC50: 1.8 mM637997 2D-image
4-nitrophthalhydrazideBos taurus-IC50: 0.51 mM637997 2D-image
4296-1011Pseudomonas aeruginosa-restores yeast growth after treatment with ExoS694800 2D-image
5-acetamidosalicylamideBos taurus-IC50: 0.045 mM637997 2D-image
5-aminosalicylamideBos taurus-IC50: 0.1 mM637997 2D-image
5-BromodeoxyuridineBos taurus-IC50: 0.015 mM638001 2D-image
5-BromouracilBos taurus-IC50: 0.16 mM637997 2D-image
5-BromouridineBos taurus-IC50: 0.21 mM637997 2D-image
5-chlorosalicylamideBos taurus-IC50: 0.19 mM637997 2D-image
5-ChlorouracilBos taurus-IC50: 0.27 mM637997 2D-image
5-hydroxy-1,4-naphthoquinoneBos taurus-IC50: 0.25 mM637997 2D-image
5-Hydroxy-2-methyl-1,4-naphthoquinoneBos taurus-IC50: 0.7 mM637997 2D-image
5-IodouracilBos taurus-IC50: 0.071 mM637997 2D-image
5-iodouridineBos taurus-IC50: 0.043 mM637997 2D-image
5-MethylnicotinamideBos taurus-IC50: 0.35 mM637997 2D-image
5-MethylnicotinamideCryptothecodinium cohnii-0.15 mM, 31% inhibition637998 2D-image
5-MethylnicotinamideBos taurus-IC50: 0.07638001 2D-image
5-methyluracilBos taurus-IC50: 0.29 mM637997 2D-image
5-NitrouracilBos taurus-IC50: 0.43 mM637997 2D-image
6(5H)-phenanthridinoneBos taurus-IC50: 0.0003 mM637997 2D-image
6-aminocoumarinBos taurus-IC50: 0.85 mM637997 2D-image
6-AminonicotinamideBos taurus-IC50: 1.1 mM637997 2D-image
8-acetamidocarsalamBos taurus-IC50: 1.4 mM637997 2D-image
8-MethylnicotinamideBos taurus-IC50: 7.8 mM638001 2D-image
acetophenoneBos taurus-IC50: 2.3 mM637997 2D-image
AG14361Mus musculus--672809 2D-image
all-trans-retinalBos taurus-IC50: 0.45 mM637997 2D-image
Alpha-NAD+Dictyostelium discoideum-0.5 mM, 40% inhibition of the 116000 Da enzyme, 44% inhibition of the 90000 Da enzyme637993 2D-image
alpha-picolinamideBos taurus-IC50: 0.25 mM637997 2D-image
arachidonic acidBos taurus--637997 2D-image
BenzamideBos taurus-IC50: 0.22 mM637997 2D-image
BenzamideCryptothecodinium cohnii-0.15 mM, 48% inhibition637998 2D-image
BenzamideBos taurus-IC50: 0.0033 mM638001 2D-image
benzoyleneureaBos taurus-IC50: 0.0081 mM637997 2D-image
CaffeineHelix pomatia-1 mM, 23% inhibition637992 2D-image
CaffeineDictyostelium discoideum-1 mM, 86% inhibition of the 116000 Da enzyme, 57% inhibition of the 90000 Da enzyme637993 2D-image
CaffeineBos taurus-IC50: 1.4 mM638001 2D-image
carbonylsalicylamideBos taurus-IC50: 0.46 mM637997 2D-image
carsalamBos taurus-5 mM, 88% inhibition in presence of Mg2+, 68% inhibition in absence of Mg2+637997 2D-image
ChlorthenoxazinBos taurus-IC50: 0.0085 mM637997 2D-image
chromone-2-carboxylic acidBos taurus-IC50: 0.56 mM637997 2D-image
Cu2+Homo sapiens--637991 2D-image
cyclohexanecarboxamideBos taurus-IC50: 0.62 mM637997 2D-image
diosminPseudomonas aeruginosa-restores yeast growth after treatment with ExoS694800 2D-image
E216-5303Pseudomonas aeruginosa-restores yeast growth after treatment with ExoS694800 2D-image
EDTABos taurus-5 mM, 41% inhibition in presence of Mg2+, 2% inhibition in absence of Mg2+637997 2D-image
everninic acidPseudomonas aeruginosa-restores yeast growth after treatment with ExoS694800 2D-image
exosinPseudomonas aeruginosa-a small molecule inhibitor, that modulates ExoS ADP-ribosyltransferase activity in vitro, suggesting the inhibition is direct. Exosin and two of its analogues display a significant protective effect against Pseudomonas infection in vivo, competitive against NAD+694800 2D-image
flavokawain BPseudomonas aeruginosa-restores yeast growth after treatment with ExoS694800 2D-image
flavoneBos taurus-IC50: 0.022 mM637997 2D-image
gamma-linolenic acidBos taurus-IC50: 0.12 mM637997 2D-image
GTP(gammaS)Dictyostelium discoideum-in presence of Mg2+637993 2D-image
Hg2+Homo sapiens--637991 2D-image
hypoxanthineBos taurus-IC50: 1.7 mM638001 2D-image
IsonicotinamideBos taurus-IC50: 0.99 mM637997 2D-image
Isonicotinate hydrazideBos taurus-IC50: 4.8 MM638001 2D-image
IsoquinolineBos taurus-5 mM, 47% inhibition in presence of Mg2+, 34% inhibition in absence of Mg2+637997 2D-image
KClDictyostelium discoideum-100 mM, 85% inhibition of the 90000 Da enzyme637993 2D-image
linoleic acidBos taurus-IC50: 0.048 mM637997 2D-image
linolenic acidBos taurus-IC50: 0.11 mM637997 2D-image
m-acetamidoacetophenoneBos taurus-IC50: 0.93 mM637997 2D-image
m-aminoacetophenoneBos taurus-IC50: 1.9 mM637997 2D-image
m-hydroxyacetophenoneBos taurus-IC50: 0.6 mM637997 2D-image
m-phthalamideBos taurus-IC50: 0.05 mM637997 2D-image
N-(2-chloroethyl)1,8-naphthalamideBos taurus-IC50: above 1.8 mM637997 2D-image
N-hydroxynaphthalimide sodium saltBos taurus-IC50: 0.45 mM637997 2D-image
NEMMesocricetus auratus-0.5 mM637995 2D-image
NicotinamideHomo sapiens-1 mM, 93% inhibition637991 2D-image
NicotinamideHelix pomatia-1 mM, 91% inhibition637992 2D-image
NicotinamideDictyostelium discoideum-1 mM, 96% inhibition of the 116000 Da enzyme, 95% inhibition of the 90000 Da enzyme637993 2D-image
NicotinamideMesocricetus auratus--637995 2D-image
NicotinamideBos taurus-IC50: 0.21 mM637997 2D-image
NicotinamideCryptothecodinium cohnii-0.15 mM, 25% inhibition637998 2D-image
NicotinamideBos taurus-IC50: 0.031 mM638001 2D-image
norharmanBos taurus-IC50: 4.7 mM637997 2D-image
novobiocinBos taurus-IC50: 2.2 mM, 5 mM, 90% inhibition in presence of Mg2+, 59% inhibition in absence of Mg2+637997 2D-image
oleic acidBos taurus-IC50: 0.082 mM637997 2D-image
palmitoleic acidBos taurus-IC50: 0.095 mM637997 2D-image
PCMBHomo sapiens-complete637991 2D-image
phthalamideBos taurus-IC50: 1.0 mM637997 2D-image
PhthalazineBos taurus-5 mM, 91% inhibition in presence of Mg2+, 79% inhibition in absence of Mg2+637997 2D-image
PJ34Mus musculus-potent PARP inhibitor671255 2D-image
PyrazinamideBos taurus-IC50: 0.13 mM638001 2D-image
QuinazolineBos taurus-5 mM, 63% inhibition in presence of Mg2+, 50% inhibition in absence of Mg2+637997 2D-image
reserpineBos taurus-IC50: 0.79 mM637997 2D-image
TheobromineHelix pomatia-1 mM, 76% inhibition637992 2D-image
TheobromineBos taurus-IC50: 0.11 mM638001 2D-image
theophyllineHelix pomatia-1 mM, 72% inhibition637992 2D-image
theophyllineDictyostelium discoideum-1 mM, 68% inhibition of the 116000 Da enzyme, 39% inhibition of the 90000 Da enzyme637993 2D-image
theophyllineCryptothecodinium cohnii-0.15 mM, 62% inhibition637998 2D-image
theophyllineBos taurus-IC50: 0.0046638001 2D-image
ThiobenzamideBos taurus-IC50: 0.62 mM637997 2D-image
ThionicotinamideBos taurus-IC50: 1.8 mM637997 2D-image
thymidineHelix pomatia-1 mM, 70% inhibition637992 2D-image
thymidineDictyostelium discoideum-1 mM, 94% inhibition of the 116000 Da enzyme, 88% inhibition of the 90000 Da enzyme637993 2D-image
thymidineMesocricetus auratus--637995 2D-image
thymidineBos taurus-IC50: 0.18 mM637997 2D-image
thymidineCryptothecodinium cohnii-0.15 mM, 39% inhibition637998 2D-image
thymidineBos taurus-IC50: 0.043638001 2D-image
trans-decahydro-1-naphthalenoneBos taurus-IC50: 4.3 mM637997 2D-image
vitamin K1Bos taurus-IC50: 0.0019 mM637997 2D-image
vitamin K3Bos taurus-IC50: 0.42 mM637997 2D-image
xanthurenic acidBos taurus-5 mM, 88% inhibition in presence of Mg2+, 65% inhibition in absence of Mg2+637997 2D-image
Zn2+Homo sapiens--637991 2D-image
Zn2+Bos taurus-ZnCl2, IC50: 0.077 mM638001 2D-image
menadione sodium bisulfiteBos taurus-IC50: 0.72 mM637997 2D-image
additional informationMus musculus-PARP inhibitors promote ATM activation through induction of double strand breaks672809-
additional informationBos taurus-comparison of the effects of heterocyclic amines acting as potent carcinogens on PARP-1 and the arginine-specific mono-ADP-ribosyltransferase A, MART-A, EC 2.4.2.31, overview675627-
additional informationPseudomonas aeruginosa-identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screening, overview694800-

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
3-amino-1-methyl-5H-pyrido[4,3-b]indoleBos taurus-i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM675627 2D-image
ATPMesocricetus auratus-5-10 mM, 20-30% stimulation637995 2D-image
Bmh1pPseudomonas aeruginosa-a yeast homologue of the human FAS, acts as an activating ExoS cofactor, overview694800-
DNAHomo sapiens-absolute requirement637991 2D-image
DNADictyostelium discoideum-absolute requirement637993 2D-image
DNACryptothecodinium cohnii-required637998 2D-image
DNABos taurus-the enzyme is completely dependent on the presence of DNA containing single or double stranded breaks. Activation results in a decondensation of chromatin superstructure in vitro, which is caused mainly by hyper(ADP-ribosyl)ation of histone H1637999 2D-image
DNAHomo sapiens-enzyme has an N-terminal binding domain638000 2D-image
FASPseudomonas aeruginosa-exoenzyme S absolutely requires a soluble eukaryotic protein, named FAS (Factor Activating exoenzyme E), in order to ADP-ribosylate all substrates. In the presence of FAS, exoenzyme S ADP-ribosylates several proteins in lysates of Pseudomonas aeruginosa. Purification and characterization of FAS662089-
GDPClostridium botulinum-increases activity in absence of Mg2+637994 2D-image
GTPClostridium botulinum-increases activity in absence of Mg2+637994 2D-image
GTP(gammaS)Clostridium botulinum-increases activity in absence of Mg2+637994 2D-image
Phthalic acidBos taurus-activates more strongly in absence of Mg2+ than in presence of Mg2+637997 2D-image
protein 14-3-3Pseudomonas aeruginosa-dependent on672996-
protein 14-3-3Pseudomonas aeruginosa-required, interaction analysis, interaction equires residues L426, D427, and L428, overview, binding study of mutant enzymes, overview673573-
harmaline hydrochlorideBos taurus-activates more strongly in absence of Mg2+ than in presence of Mg2+637997 2D-image
additional informationPseudomonas aeruginosa-in native conformation, CRM66 shows limited ability to modify EF-2 covalently. Upon activation with urea and dithiothreitol CRM66 loses ADP-ribosylation activity entirely, yet it retains the ability to bind NAD+. Replacement of Tyr-426 with histidine in CRM66 completely restores cytotoxicity and ADP-ribosyltransferase activity662087-
additional informationMus musculus-PARP-1 is activated in response to DNA damage and participates in DNA repair, genomic integrity and cell death671255-
additional informationHomo sapiens-stable expression of the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP, clone KIAA0827/amino acids 1-547, in HEK-293 cells increases the expression of the enzyme671265-
additional informationMus musculus-DNA binding by PARP-1 triggers its activity and it adds poly(ADP-ribose) polymers to itself and to surrounding histones, overview672969-

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.03-(ADP-D-ribosyl)n-soybean-trypsin-inhibitorPseudomonas aeruginosa-recombinant full-length enzyme661868-
0.037-(ADP-D-ribosyl)n-soybean-trypsin-inhibitorPseudomonas aeruginosa-recombinant DELTAN222661868-
0.049-(ADP-D-ribosyl)n-soybean-trypsin-inhibitorPseudomonas aeruginosa-DELTAN222661051-
0.23-(ADP-D-ribosyl)n-soybean-trypsin-inhibitorPseudomonas aeruginosa-DELTAN222/E381S661051-
0.387-(ADP-D-ribosyl)n-soybean-trypsin-inhibitorPseudomonas aeruginosa-DELTAN222/E381D661051-
0.002-NAD+Clostridium botulinum--637994 2D-image
0.009-NAD+Pseudomonas aeruginosa-pH 6.0, 30°C, in absence of exosin694800 2D-image
0.0171-NAD+Bacillus cereus-pH 7.3, 37°C, cosubstrate RhoC658013 2D-image
0.02-NAD+Dictyostelium discoideum-90000 Da protein637993 2D-image
0.02-NAD+Rattus norvegicus-hydrolysis of NAD+, wild-type enzyme657940 2D-image
0.0208-NAD+Bacillus cereus-pH 7.3, 37°C, cosubstrate RhoA658013 2D-image
0.0267-NAD+Helix pomatia--637992 2D-image
0.03-NAD+Pseudomonas aeruginosa-pH 6.0, 30°C, in presence of exosin694800 2D-image
0.0564-NAD+Bacillus cereus-pH 7.3, 37°C, cosubstrate RhoB658013 2D-image
0.077-NAD+Dictyostelium discoideum-116000 Da protein637993 2D-image
0.154-NAD+Sulfolobus solfataricus--678019 2D-image
0.22-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme F349A, cosubstrate: non-muscle actin from human platelets657492 2D-image
0.58-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme N255A, cosubstrate: non-muscle actin from human platelets657492 2D-image
0.69-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme F349A, cosubstrate: rabbit muscle actin657492 2D-image
0.77-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, wild-type enzyme, cosubstrate: non-muscle actin from human platelets657492 2D-image
0.92-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme Y246A, cosubstrate: non-muscle actin from human platelets657492 2D-image
0.93-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme Y246A, cosubstrate: rabbit muscle actin657492 2D-image
1.28-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, wild-type enzyme, cosubstrate: rabbit muscle actin657492 2D-image
4.48-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme N255A, cosubstrate: rabbit muscle actin657492 2D-image
8.67-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme Y251A, cosubstrate: non-muscle actin from human platelets657492 2D-image
0.429-(ADP-D-ribosyl)n-soybean-trypsin-inhibitorPseudomonas aeruginosa-DELTAN222/E381A661051-
additional information-additional informationMesocricetus auratus-kinetics for NAD+ utilization are not Michaelis-Menten type637995-
additional information-additional informationPseudomonas aeruginosa--661051-

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.0031-(ADP-D-ribosyl)n-soybean-trypsin-inhibitorPseudomonas aeruginosa-recombinant DELTAN222661868-
0.008-(ADP-D-ribosyl)n-soybean-trypsin-inhibitorPseudomonas aeruginosa-recombinant full-length enzyme661868-
6.7e-05-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme F349A, cosubstrate: non-muscle actin from human platelets657492 2D-image
0.00012-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme F349A, cosubstrate: rabbit muscle actin657492 2D-image
0.00015-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme Y246A, cosubstrate: rabbit muscle actin657492 2D-image
0.0002-NAD+Rattus norvegicus-hydrolysis of NAD+, mutant enzyme Q187A/189A657940 2D-image
0.0005-NAD+Rattus norvegicus-hydrolysis of NAD+, mutant enzyme E189I657940 2D-image
0.00133-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme Y246A, cosubstrate: non-muscle actin from human platelets; ADP-ribosyltransferase activity, mutant enzyme Y251A, cosubstrate: non-muscle actin from human platelets657492 2D-image
0.00183-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme N255A, cosubstrate: non-muscle actin from human platelets657492 2D-image
0.002-NAD+Rattus norvegicus-hydrolysis of NAD+, mutant enzyme E189A; hydrolysis of NAD+, mutant enzyme E189S657940 2D-image
0.0062-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, wild-type enzyme, cosubstrate: non-muscle actin from human platelets657492 2D-image
0.01-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, wild-type enzyme, cosubstrate: rabbit muscle actin657492 2D-image
0.014-NAD+Clostridium perfringens-ADP-ribosyltransferase activity, mutant enzyme N255A, cosubstrate: rabbit muscle actin657492 2D-image
0.04-NAD+Sulfolobus solfataricus--678019 2D-image
12-NAD+Rattus norvegicus-hydrolysis of NAD+, wild-type enzyme657940 2D-image

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.033-exosinPseudomonas aeruginosa-pH 6.0, 30°C694800 2D-image

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.012-1(2H)-phthalazinoneBos taurus-IC50: 0.012 mM637997 2D-image
2.8-1,2-benzopyroneBos taurus-IC50: 2.8 mM637997 2D-image
2-1,3-benzodiazineBos taurus-IC50: 2.0 mM637997 2D-image
1.3-1,3-dihydroxynaphthaleneBos taurus-IC50: 1.3 mM637997 2D-image
0.4-1,4-benzoquinoneBos taurus-IC50: 0.4 mM637997 2D-image
0.25-1,4-naphthalenedioneBos taurus-IC50: 0.25 mM637997 2D-image
0.00039-1,5-dihydroxyisoquinolineBos taurus-IC50: 0.00039 mM637997 2D-image
0.0014-1,8-naphthalimideBos taurus-IC50: 0.0014 mM637997 2D-image
1.3-1-hydroxy-2-methyl-4-aminonaphthaleneBos taurus-IC50: 1.3 mM637997 2D-image
0.007-1-hydroxyisoquinolineBos taurus-IC50: 0.007 mM637997 2D-image
0.81-1-IndanoneBos taurus-IC50: 0.81 mM637997 2D-image
1.7-1-methylnicotinamide chlorideBos taurus-IC50: 1.7 mM638001 2D-image
3.8-1-methylnicotinamide chlorideBos taurus-IC50: 3.8 mM637997 2D-image
0.15-2,3-benzodiazineBos taurus-IC50: 0.15 mM637997 2D-image
0.26-2,3-dichloro-1,4-naphthoquinoneBos taurus-IC50: 0.26 mM637997 2D-image
0.03-2,3-dihydro-1,4-phthalazinedioneBos taurus-IC50: 0.03 mM637997 2D-image
0.0081-2,4(1H,3H)-quinazolinedioneBos taurus-IC50: 0.0081 mM637997 2D-image
0.18-2,6-difluorobenzamideBos taurus-IC50: 0.18 mM637997 2D-image
1-2-acetamidobenzamideBos taurus-IC50: 1.0 mM637997 2D-image
0.82-2-amino-3-chloro-1,4-naphthoquinoneBos taurus-IC50: 0.82 mM637997 2D-image
0.1-2-AminobenzamideBos taurus-IC50: 0.1 mM638001 2D-image
0.65-2-AminobenzamideBos taurus-IC50: 0.65 mM637997 2D-image
2.9-2-bromobenzamideBos taurus-IC50: 2.9 mM637997 2D-image
1-2-chlorobenzamideBos taurus-IC50: 1.0 mM637997 2D-image
0.12-2-fluorobenzamideBos taurus-IC50: 0.12 mM637997 2D-image
0.33-2-Hydroxy-1,4-naphthoquinoneBos taurus-IC50: 0.33 mM637997 2D-image
0.82-2-hydroxybenzamideBos taurus-IC50: 0.82 mM637997 2D-image
0.044-2-mercapto-4(3H)-quinazolinoneBos taurus-IC50: 0.044 mM637997 2D-image
0.2-2-MethoxybenzamideBos taurus-IC50: 0.2 mM637997 2D-image
0.045-2-methyl-1,4-benzopyroneBos taurus-IC50: 0.045 mM637997 2D-image
0.42-2-methyl-1,4-naphthoquinoneBos taurus-IC50: 0.42 mM637997 2D-image
0.52-2-methyl-3-phytyl-1,4-naphthoquinoneBos taurus-IC50: 0.52 mM637997 2D-image
0.056-2-methyl-4(3H)-quinazolinoneBos taurus-IC50: 0.056 mM637997 2D-image
1.5-2-methylbenzamideBos taurus-IC50: 1.5 mM637997 2D-image
0.045-2-methylchromoneBos taurus-IC50: 0.045 mM637997 2D-image
0.00035-2-nitro-6(5H)-phenanthridioneBos taurus-IC50: 0.00035 mM637997 2D-image
0.022-2-phenylchromoneBos taurus-IC50: 0.022 mM637997 2D-image
2.2-2-trichloromethyl-4(3H)-quinazolinoneBos taurus-IC50: 2.2 mM637997 2D-image
0.0003-2H-benz[c]isoquinolin-1-oneBos taurus-IC50: 0.0003 mM637997 2D-image
0.0014-2H-benz[de]isoquinoline-1,3-dioneBos taurus-IC50: 0.0014 mM637997 2D-image
0.31-3,4-dihydro-1(2H)-naphthalenoneBos taurus-IC50: 0.31 mM637997 2D-image
0.56-3,5-dibromosalicylamideBos taurus-IC50: 0.56 mM637997 2D-image
1.2-3,5-dimethoxybenzamideBos taurus-IC50: 1.2 mM637997 2D-image
2.5-3,5-dinitrobenzamideBos taurus-IC50: 2.5 mM637997 2D-image
0.12-3-(N,N-dimethylamino)benzamideBos taurus-IC50: 0.12 mM637997 2D-image
0.012-3-AcetamidobenzamideBos taurus-IC50: 0.012 mM637997 2D-image
2-3-acetamidosalicylamideBos taurus-IC50: 2.0 mM637997 2D-image
0.22-3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indoleBos taurus-i.e. Trp-P-1, 94% inhibition at 5 mM, IC50: 0.22 mM675627 2D-image
2.2-3-amino-1-methyl-5H-pyrido[4,3-b]indoleBos taurus-i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM675627 2D-image
0.0054-3-AminobenzamideBos taurus-IC50: 0.0054638001 2D-image
0.33-3-AminobenzamideBos taurus-IC50: 0.33 mM637997 2D-image
0.023-3-AminophthalhydrazideBos taurus-IC50: 0.023 mM637997 2D-image
0.055-3-bromobenzamideBos taurus-IC50: 0.055 mM637997 2D-image
0.22-3-ChlorobenzamideBos taurus-IC50: 0.22 mM637997 2D-image
0.2-3-FluorobenzamideBos taurus-IC50: 0.2 mM637997 2D-image
0.0091-3-HydroxybenzamideBos taurus-IC50: 0.0091 mM637997 2D-image
3.1-3-isobutyl-1-methylxanthineBos taurus-IC50: 3.1 mM638001 2D-image
0.0034-3-MethoxybenzamideBos taurus-IC50: 0.0034 mM638001 2D-image
0.017-3-MethoxybenzamideBos taurus-IC50: 0.017 mM637997 2D-image
0.19-3-MethylbenzamideBos taurus-IC50: 0.19 mM637997 2D-image
0.16-3-nitrobenzamideBos taurus-IC50: 0.16 mM637997 2D-image
0.072-3-nitrophthalhydrazideBos taurus-IC50: 0.072 mM637997 2D-image
1.6-3-nitrosalicylamideBos taurus-IC50: 1.6 mM637997 2D-image
0.19-4,8-dihydroxy-2-quinolinecarboxylic acidBos taurus-IC50: 0.19 mM637997 2D-image
0.00018-4-amino-1,8-naphthalimideBos taurus-IC50: 0.00018 mM637997 2D-image
0.4-4-AminobenzamideBos taurus-IC50: 0.4 mM638001 2D-image
1.8-4-AminobenzamideBos taurus-IC50: 1.8 mM637997 2D-image
0.29-4-aminophthalhydrazideBos taurus-IC50: 0.29 mM637997 2D-image
2.2-4-bromobenzamideBos taurus-IC50: 2.2 mM637997 2D-image
0.3-4-chlorobenzamideBos taurus-IC50: 0.3 mM637997 2D-image
0.72-4-chromanoneBos taurus-IC50: 0.72 mM637997 2D-image
0.2-4-fluorobenzamideBos taurus-IC50: 0.2 mM637997 2D-image
0.074-4-hydroxy-2-methylquinolineBos taurus-IC50: 0.074 mM637997 2D-image
0.67-4-hydroxy-2-quinolinecarboxylic acidBos taurus-IC50: 0.67 mM637997 2D-image
0.28-4-hydroxybenzamideBos taurus-IC50: 0.28 mM637997 2D-image
0.57-4-HydroxycoumarinBos taurus-IC50: 0.57 mM637997 2D-image
2.3-4-hydroxypyridineBos taurus-IC50: 2.3 mM637997 2D-image
0.0095-4-hydroxyquinazolineBos taurus-IC50: 0.0095 mM637997 2D-image
0.08-4-hydroxyquinolineBos taurus-IC50: 0.08 mM637997 2D-image
1.1-4-methoxybenzamideBos taurus-IC50: 1.1 mM637997 2D-image
1.8-4-methylbenzamideBos taurus-IC50: 1.8 mM637997 2D-image
0.51-4-nitrophthalhydrazideBos taurus-IC50: 0.51 mM637997 2D-image
0.006-4296-1011Pseudomonas aeruginosa-pH 6.0, 30°C694800 2D-image
0.045-5-acetamidosalicylamideBos taurus-IC50: 0.045 mM637997 2D-image
0.1-5-aminosalicylamideBos taurus-IC50: 0.1 mM637997 2D-image
0.015-5-BromodeoxyuridineBos taurus-IC50: 0.015 mM638001 2D-image
0.16-5-BromouracilBos taurus-IC50: 0.16 mM637997 2D-image
0.21-5-BromouridineBos taurus-IC50: 0.21 mM637997 2D-image
0.19-5-chlorosalicylamideBos taurus-IC50: 0.19 mM637997 2D-image
0.27-5-ChlorouracilBos taurus-IC50: 0.27 mM637997 2D-image
0.25-5-hydroxy-1,4-naphthoquinoneBos taurus-IC50: 0.25 mM637997 2D-image
0.7-5-Hydroxy-2-methyl-1,4-naphthoquinoneBos taurus-IC50: 0.7 mM637997 2D-image
0.071-5-IodouracilBos taurus-IC50: 0.071 mM637997 2D-image
0.043-5-iodouridineBos taurus-IC50: 0.043 mM637997 2D-image
0.07-5-MethylnicotinamideBos taurus-IC50: 0.07 mM638001 2D-image
0.35-5-MethylnicotinamideBos taurus-IC50: 0.35 mM637997 2D-image
0.29-5-methyluracilBos taurus-IC50: 0.29 mM637997 2D-image
0.43-5-NitrouracilBos taurus-IC50: 0.43 mM637997 2D-image
0.0003-6(5H)-phenanthridinoneBos taurus-IC50: 0.0003 mM637997 2D-image
0.85-6-aminocoumarinBos taurus-IC50: 0.85 mM637997 2D-image
1.1-6-AminonicotinamideBos taurus-IC50: 1.1 mM637997 2D-image
1.4-8-acetamidocarsalamBos taurus-IC50: 1.4 mM637997 2D-image
7.8-8-MethylnicotinamideBos taurus-IC50: 7.8 mM638001 2D-image
2.3-acetophenoneBos taurus-IC50: 2.3 mM637997 2D-image
0.45-all-trans-retinalBos taurus-IC50: 0.45 mM637997 2D-image
0.25-alpha-picolinamideBos taurus-IC50: 0.25 mM637997 2D-image
0.0033-BenzamideBos taurus-IC50: 0.0033 mM638001 2D-image
0.22-BenzamideBos taurus-IC50: 0.22 mM637997 2D-image
0.0081-benzoyleneureaBos taurus-IC50: 0.0081 mM637997 2D-image
1.4-CaffeineBos taurus-IC50: 1.4 mM638001 2D-image
0.46-carbonylsalicylamideBos taurus-IC50: 0.46 mM637997 2D-image
0.0085-ChlorthenoxazinBos taurus-IC50: 0.0085 mM637997 2D-image
0.56-chromone-2-carboxylic acidBos taurus-IC50: 0.56 mM637997 2D-image
0.62-cyclohexanecarboxamideBos taurus-IC50: 0.62 mM637997 2D-image
0.003-diosminPseudomonas aeruginosa-pH 6.0, 30°C694800 2D-image
0.023-E216-5303Pseudomonas aeruginosa-pH 6.0, 30°C694800 2D-image
0.021-everninic acidPseudomonas aeruginosa-pH 6.0, 30°C694800 2D-image
0.022-flavoneBos taurus-IC50: 0.022 mM637997 2D-image
0.12-gamma-linolenic acidBos taurus-IC50: 0.12 mM637997 2D-image
1.7-hypoxanthineBos taurus-IC50: 1.7 mM638001 2D-image
0.99-IsonicotinamideBos taurus-IC50: 0.99 mM637997 2D-image
4.8-Isonicotinate hydrazideBos taurus-IC50: 4.8 mM638001 2D-image
0.048-linoleic acidBos taurus-IC50: 0.048 mM637997 2D-image
0.11-linolenic acidBos taurus-IC50: 0.11 mM637997 2D-image
0.93-m-acetamidoacetophenoneBos taurus-IC50: 0.93 mM637997 2D-image
1.9-m-aminoacetophenoneBos taurus-IC50: 1.9 mM637997 2D-image
0.6-m-hydroxyacetophenoneBos taurus-IC50: 0.6 mM637997 2D-image
0.05-m-phthalamideBos taurus-IC50: 0.05 mM637997 2D-image
0.72-menadione sodium bisulfiteBos taurus-IC50: 0.72 mM637997 2D-image
1.8-N-(2-chloroethyl)1,8-naphthalamideBos taurus-IC50: above 1.8 mM637997 2D-image
0.45-N-hydroxynaphthalimide sodium saltBos taurus-IC50: 0.45 mM637997 2D-image
0.031-NicotinamideBos taurus-IC50: 0.031 mM638001 2D-image
0.21-NicotinamideBos taurus-IC50: 0.21 mM637997 2D-image
4.7-norharmanBos taurus-IC50: 4.7 mM637997 2D-image
2.2-novobiocinBos taurus-IC50: 2.2 mM, 5 mM, 90% inhibition in presence of Mg2+, 59% inhibition in absence of Mg2+637997 2D-image
0.082-oleic acidBos taurus-IC50: 0.082 mM637997 2D-image
0.095-palmitoleic acidBos taurus-IC50: 0.095 mM637997 2D-image
1-phthalamideBos taurus-IC50: 1.0 mM637997 2D-image
0.13-PyrazinamideBos taurus-IC50: 0.13 mM638001 2D-image
0.79-reserpineBos taurus-IC50: 0.79 mM637997 2D-image
0.11-TheobromineBos taurus-IC50: 0.11 mM638001 2D-image
0.046-theophyllineBos taurus-IC50: 0.046 mM638001 2D-image
0.62-ThiobenzamideBos taurus-IC50: 0.62 mM637997 2D-image
1.8-ThionicotinamideBos taurus-IC50: 1.8 mM637997 2D-image
0.043-thymidineBos taurus-IC50: 0.043 mM638001 2D-image
0.18-thymidineBos taurus-IC50: 0.18 mM637997 2D-image
4.3-trans-decahydro-1-naphthalenoneBos taurus-IC50: 4.3 mM637997 2D-image
0.0019-vitamin K1Bos taurus-IC50: 0.0019 mM637997 2D-image
0.42-vitamin K3Bos taurus-IC50: 0.42 mM637997 2D-image
0.077-Zn2+Bos taurus-ZnCl2, IC50: 0.077 mM638001 2D-image

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
0.0017-Dictyostelium discoideum--637993
0.0545-Helix pomatia--637992
0.325-Homo sapiens--637996
1.02-Homo sapiens--637991
22.25-Bacillus cereus--658013
80-Clostridium limosum-wild-type enzyme, substrate RhoA672048
83-Sulfolobus solfataricus--678019

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
6-Pseudomonas aeruginosa-assay at694800
7.4-Mus musculus-assay at671826
7.4-Clostridium limosum-assay at672048
7.5-Mus musculus-assay at675025
7.6-Pseudomonas aeruginosa-assay at672996
8-Helix pomatia--637992
8-Dictyostelium discoideum-in presence of DNA and histone H1637993
8-Mesocricetus auratus--637995
8-Bos taurus-assay at675627
8-Sulfolobus solfataricus--678019
8.5-Homo sapiens-reaction with histone in presence of DNA, 0.1 M glycine-NaOH buffer637991
8.7-Homo sapiens-reaction with histone in presence of DNA, 0.1 M Tris-HCl buffer637991

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
79.5Sulfolobus solfataricus-pH 7.0: about 75% of maximal activity, pH 9.5: about 70% of maximal activity678019

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
5-Dictyostelium discoideum-116000 Da enzyme637993
10-Dictyostelium discoideum-90000 Da enzyme637993
18-Helix pomatia--637992
25-Mesocricetus auratus--637995
3037Clostridium limosum-assay at672048
30-Pseudomonas aeruginosa-assay at694800
37-Mus musculus-assay at671826
37-Bos taurus-assay at675627
80-Sulfolobus solfataricus--678019

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
5.3-Pseudomonas aeruginosa-isoelectric focusing. ExoS shows pI heterogeneity, that is independent of a mass change and thus represents molecular charge conformers661065
5.5-Pseudomonas aeruginosa-isoelectric focusing. ExoS shows pI heterogeneity, that is independent of a mass change and thus represents molecular charge conformers661065
5.7-Pseudomonas aeruginosa-isoelectric focusing. ExoS shows pI heterogeneity, that is independent of a mass change and thus represents molecular charge conformers661065
5.9-Pseudomonas aeruginosa-isoelectric focusing. ExoS shows pI heterogeneity, that is independent of a mass change and thus represents molecular charge conformers661065
9.3-Bacillus cereus-theoretical value658013

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
BHK-21 cellMesocricetus auratus--637995Manually annotated by BRENDA team
C2C12 cellMus musculus--671826Manually annotated by BRENDA team
culture fluidPseudomonas aeruginosa--661867Manually annotated by BRENDA team
culture supernatantPseudomonas aeruginosa--661867Manually annotated by BRENDA team
endothelial cellMus musculus-primary675022Manually annotated by BRENDA team
epithelial cellMus musculus--671255Manually annotated by BRENDA team
fibroblastMus musculus-primary, from lung671255Manually annotated by BRENDA team
fibroblastMus musculus--675025Manually annotated by BRENDA team
footHelix pomatia--637992Manually annotated by BRENDA team
HEK-293 cellHomo sapiens--671265Manually annotated by BRENDA team
lungMus musculus-PARP-1 in lung repair during recovery after hyperoxia, that is induced by 5-bromo-2’-deoxyuridine, overview671255Manually annotated by BRENDA team
lymphoma cellMus musculus-transfectants expressing either ART2.2 with its native anchor (RT2.2-GPI) or ART2.2 with a grafted transmembrane anchor658344Manually annotated by BRENDA team
myoblastMus musculus--671826Manually annotated by BRENDA team
NIH-3T3 cellMus musculus--672809Manually annotated by BRENDA team
placentaHomo sapiens--637991Manually annotated by BRENDA team
skeletal muscleMus musculus--671826Manually annotated by BRENDA team
T-cell lymphoma cellMus musculus--658344Manually annotated by BRENDA team
thymusBos taurus--637997, 638001, 675627Manually annotated by BRENDA team

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
chromatinTrypanosoma brucei-TbSIR2RP1 is a nuclear protein that colocalizes with telomeric sequences and minichromosomes785658546Manually annotated by BRENDA team
cytoplasmHomo sapiens--5737671265Manually annotated by BRENDA team
cytosolMesocricetus auratus-10% of the activity5829637995Manually annotated by BRENDA team
nucleusMesocricetus auratus-90% of the activity. Chromatin-bound5634637995Manually annotated by BRENDA team
nucleusHomo sapiens--5634637996, 671265Manually annotated by BRENDA team
nucleusBos taurus--5634637999Manually annotated by BRENDA team
nucleusMus musculus--5634672809, 673854Manually annotated by BRENDA team
nucleusDrosophila melanogaster--5634673854Manually annotated by BRENDA team
perinuclear spacePseudomonas aeruginosa-localizes in eukaryotic cells to the perinuclear region-662888Manually annotated by BRENDA team
periplasmNeisseria meningitidis-despite the absence of a signal peptide, the protein is efficiently exported into periplasm-659962Manually annotated by BRENDA team
polysomeHomo sapiens--5844637996Manually annotated by BRENDA team
membranePseudomonas aeruginosa-membrane localization domain16020663377Manually annotated by BRENDA team
additional informationPseudomonas aeruginosa-residues 51–72 represent a membrane localization domain, which targets ExoS to perinuclear vesicles within mammalian cells-662234Manually annotated by BRENDA team
additional informationPseudomonas aeruginosa-residues 52-72, membrane localization domain within the N-terminus of ExoS, is necessary and sufficient for membrane localization within eukaryotic cells, plays a role in targeting of ExoS to eukaryotic signalling factors-662890Manually annotated by BRENDA team
additional informationMus musculus-subcellular distribution, overview-672809Manually annotated by BRENDA team

PDBSCOPCATHORGANISM
1v9x, downloadSCOP (1v9x)CATH (1v9x)Arabidopsis thaliana
1uzi, downloadSCOP (1uzi)CATH (1uzi)Clostridium botulinum D phage
1a26, downloadSCOP (1a26)CATH (1a26)Gallus gallus
1efy, downloadSCOP (1efy)CATH (1efy)Gallus gallus
1pax, downloadSCOP (1pax)CATH (1pax)Gallus gallus
2paw, downloadSCOP (2paw)CATH (2paw)Gallus gallus
2pax, downloadSCOP (2pax)CATH (2pax)Gallus gallus
3pax, downloadSCOP (3pax)CATH (3pax)Gallus gallus
4pax, downloadSCOP (4pax)CATH (4pax)Gallus gallus
1uk0, downloadSCOP (1uk0)CATH (1uk0)Homo sapiens
1uk1, downloadSCOP (1uk1)CATH (1uk1)Homo sapiens
1wok, downloadSCOP (1wok)CATH (1wok)Homo sapiens
2cok, downloadSCOP (2cok)CATH (2cok)Homo sapiens
2cr9, downloadSCOP (2cr9)CATH (2cr9)Homo sapiens
2cs2, downloadSCOP (2cs2)CATH (2cs2)Homo sapiens
2eoc, downloadSCOP (2eoc)CATH (2eoc)Homo sapiens
2jvn, downloadSCOP (2jvn)CATH (2jvn)Homo sapiens
2l30, downloadSCOP (2l30)CATH (2l30)Homo sapiens
2l31, downloadSCOP (2l31)CATH (2l31)Homo sapiens
2pqf, downloadSCOP (2pqf)CATH (2pqf)Homo sapiens
2rcw, downloadSCOP (2rcw)CATH (2rcw)Homo sapiens
2rd6, downloadSCOP (2rd6)CATH (2rd6)Homo sapiens
2rf5, downloadSCOP (2rf5)CATH (2rf5)Homo sapiens
2riq, downloadSCOP (2riq)CATH (2riq)Homo sapiens
2y0i, downloadSCOP (2y0i)CATH (2y0i)Homo sapiens
3blj, downloadSCOP (3blj)CATH (3blj)Homo sapiens
3c49, downloadSCOP (3c49)CATH (3c49)Homo sapiens
3c4h, downloadSCOP (3c4h)CATH (3c4h)Homo sapiens
3ce0, downloadSCOP (3ce0)CATH (3ce0)Homo sapiens
3fhb, downloadSCOP (3fhb)CATH (3fhb)Homo sapiens
3gey, downloadSCOP (3gey)CATH (3gey)Homo sapiens
3gjw, downloadSCOP (3gjw)CATH (3gjw)Homo sapiens
3gn7, downloadSCOP (3gn7)CATH (3gn7)Homo sapiens
3goy, downloadSCOP (3goy)CATH (3goy)Homo sapiens
3hkv, downloadSCOP (3hkv)CATH (3hkv)Homo sapiens
3kcz, downloadSCOP (3kcz)CATH (3kcz)Homo sapiens
3kh6, downloadSCOP (3kh6)CATH (3kh6)Homo sapiens
3kjd, downloadSCOP (3kjd)CATH (3kjd)Homo sapiens
3kr7, downloadSCOP (3kr7)CATH (3kr7)Homo sapiens
3kr8, downloadSCOP (3kr8)CATH (3kr8)Homo sapiens
3l3l, downloadSCOP (3l3l)CATH (3l3l)Homo sapiens
3l3m, downloadSCOP (3l3m)CATH (3l3m)Homo sapiens
3mhj, downloadSCOP (3mhj)CATH (3mhj)Homo sapiens
3mhk, downloadSCOP (3mhk)CATH (3mhk)Homo sapiens
3od8, downloadSCOP (3od8)CATH (3od8)Homo sapiens
3oda, downloadSCOP (3oda)CATH (3oda)Homo sapiens
3odc, downloadSCOP (3odc)CATH (3odc)Homo sapiens
3ode, downloadSCOP (3ode)CATH (3ode)Homo sapiens
3p0n, downloadSCOP (3p0n)CATH (3p0n)Homo sapiens
3p0p, downloadSCOP (3p0p)CATH (3p0p)Homo sapiens
3p0q, downloadSCOP (3p0q)CATH (3p0q)Homo sapiens
3q6z, downloadSCOP (3q6z)CATH (3q6z)Homo sapiens
3q71, downloadSCOP (3q71)CATH (3q71)Homo sapiens
3se2, downloadSCOP (3se2)CATH (3se2)Homo sapiens
3smi, downloadSCOP (3smi)CATH (3smi)Homo sapiens
3smj, downloadSCOP (3smj)CATH (3smj)Homo sapiens
3twq, downloadSCOP (3twq)CATH (3twq)Homo sapiens
3twr, downloadSCOP (3twr)CATH (3twr)Homo sapiens
3tws, downloadSCOP (3tws)CATH (3tws)Homo sapiens
3twt, downloadSCOP (3twt)CATH (3twt)Homo sapiens
3twu, downloadSCOP (3twu)CATH (3twu)Homo sapiens
3twv, downloadSCOP (3twv)CATH (3twv)Homo sapiens
3tww, downloadSCOP (3tww)CATH (3tww)Homo sapiens
3twx, downloadSCOP (3twx)CATH (3twx)Homo sapiens
3u9h, downloadSCOP (3u9h)CATH (3u9h)Homo sapiens
3u9y, downloadSCOP (3u9y)CATH (3u9y)Homo sapiens
3ua9, downloadSCOP (3ua9)CATH (3ua9)Homo sapiens
3udd, downloadSCOP (3udd)CATH (3udd)Homo sapiens
3uh2, downloadSCOP (3uh2)CATH (3uh2)Homo sapiens
3uh4, downloadSCOP (3uh4)CATH (3uh4)Homo sapiens
3v2b, downloadSCOP (3v2b)CATH (3v2b)Homo sapiens
4av1, downloadSCOP (4av1)CATH (4av1)Homo sapiens
4avu, downloadSCOP (4avu)CATH (4avu)Homo sapiens
4avw, downloadSCOP (4avw)CATH (4avw)Homo sapiens
4dqy, downloadSCOP (4dqy)CATH (4dqy)Homo sapiens
4dvi, downloadSCOP (4dvi)CATH (4dvi)Homo sapiens
4f0d, downloadSCOP (4f0d)CATH (4f0d)Homo sapiens
4f0e, downloadSCOP (4f0e)CATH (4f0e)Homo sapiens
4f1l, downloadSCOP (4f1l)CATH (4f1l)Homo sapiens
4f1q, downloadSCOP (4f1q)CATH (4f1q)Homo sapiens
4hki, downloadSCOP (4hki)CATH (4hki)Homo sapiens
4hkk, downloadSCOP (4hkk)CATH (4hkk)Homo sapiens
4hkn, downloadSCOP (4hkn)CATH (4hkn)Homo sapiens
4hl5, downloadSCOP (4hl5)CATH (4hl5)Homo sapiens
4hlf, downloadSCOP (4hlf)CATH (4hlf)Homo sapiens
4hlg, downloadSCOP (4hlg)CATH (4hlg)Homo sapiens
4hlh, downloadSCOP (4hlh)CATH (4hlh)Homo sapiens
4hlk, downloadSCOP (4hlk)CATH (4hlk)Homo sapiens
4hlm, downloadSCOP (4hlm)CATH (4hlm)Homo sapiens
4hmh, downloadSCOP (4hmh)CATH (4hmh)Homo sapiens
1gs0, downloadSCOP (1gs0)CATH (1gs0)Mus musculus
3utm, downloadSCOP (3utm)CATH (3utm)Mus musculus
2hw2, downloadSCOP (2hw2)CATH (2hw2)Mycobacterium smegmatis
2le0, downloadSCOP (2le0)CATH (2le0)Rattus norvegicus

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
300000-Pseudomonas aeruginosa-ultrafiltration661867

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
?Dictyostelium discoideum-1 * 116000, two active proteins are detected: MW 90000 Da and 116000 Da, SDS-PAGE; 1 * 90000, two active proteins are detected: MW 90000 Da and 116000 Da, SDS-PAGE637993
?Clostridium botulinum-x * 25000, SDS-PAGE637994
?Pseudomonas aeruginosa-exoenzyme S activity and 53000 Da and 49000 Da proteins cofractionate, SDS-PAGE661867
?Sulfolobus solfataricus-x * 54000-55000, SDS-PAGE678019
monomerHomo sapiens-1 * 116000, SDS-PAGE637991
additional informationMus musculus-PARP-1 protein has an N-terminal DNA binding domain containing two large zinc fingers that bind to both DNA single-strand breaks and DNA double-strand breaks672969
additional informationPseudomonas aeruginosa-the N-terminus with amino acids 96–219 encodes a Rho GTPase activating protein domain, the C-terminus with amino acids 234–453 encodes a 14-3-3-dependent ADP-ribosyltransferase domain672996
additional informationMus musculus-structural and functional organizations of PARP-1 and PARP-2, overview673854
additional informationPseudomonas aeruginosa-the bifunctional ExoT contains an N-terminal GTPase-activating protein domain, GAP domain, and a C-terminal ADP-ribosyl transferase domain, ADPRT domain676823

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
proteolytic modificationPseudomonas aeruginosa-the full-length form is processed to a soluble fragment, which possesses both the GAP and ADP-ribosyltransferase activities662888

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
structure of the Ia complex with NADH at 1.8 A. Vapor diffusion methodClostridium perfringens-657492
structures of complexes between wild-type and two mutant enzymes (E189I and E189A) on the one hand and the substrate analogues beta-methylenethiazole-4-carboxamideadenine dinucleotide and NADH as well as the substrate NAD+ on the otherRattus norvegicus-657940

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
80-Sulfolobus solfataricus-half-life: 204 min678019

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
unstable in absence of Mg2+Mesocricetus auratus-637995

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-20°C, 40% glycerol, stable for several monthsPseudomonas aeruginosa-661051

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-Clostridium botulinum-637994
-Cryptothecodinium cohnii-637998
-Dictyostelium discoideum-637993
-Enterobacteria phage T4P12726659054
-Gallus gallus-659706
partialHelix pomatia-637992
-Homo sapiens-637991, 637996
-Pseudomonas aeruginosa-661867
CRM66Pseudomonas aeruginosa-662087
recombinant catalytic domain DELTAN22 and DELTAN222 mutants, expression in Escherichia coliPseudomonas aeruginosa-661051
recombinant cytosolic His function protein, rHisExoSPseudomonas aeruginosa-661868
the membrane-binding domain (amino acids 51-72) is involved in membrane binding and aggregation, which complicates the purification schemes. Purification of recombinant forms of ExoS that lack the membrane binding domain, rExoS78-453 and rExoSDELTA51-72. Both forms possess Rho GAP activity and ADP ribosyltransferase activity comparable to wild-type ExoSPseudomonas aeruginosa-663287
-Sulfolobus solfataricus-678019

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
expression in Escherichia coliBacillus cereus-658013
expression of wild-type and mutant enzymes in Escherichia coli as GST-tagged proteinsClostridium limosum-672048
trancriptional regulation, overviewDrosophila melanogaster-673854
-Enterobacteria phage T4P12726659054
40 kDa carboxy-terminal catalytic fragment of PARP-1 comprising residues 654–1014 is genetically expressed in insect cells (Spodoptera frugiperda, Sf9)Gallus gallus-659706
expression of the enzyme in HEK-293 cells using a luciferase reporter vector, PARP-1 expression analysis, overviewHomo sapiens-671265
gene PARP11, chromosomal location 12p13.3, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP14, chromosomal location 3q21.1, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP16, chromosomal location 15q22.2, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP1, chromosomal location 1q41-q42, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP2, chromosomal location 14q11.2-q12, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP3, chromosomal location 3p21.1-22.2, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP4, chromosomal location 13q11, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP6, chromosomal location 15q22.23, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene TNKS1, chromosomal location 8p23.1, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overviewHomo sapiensO95271, P09874, Q2NL67, Q460N5, Q8N5Y8, Q9NR21, Q9UGN5, Q9UKK3, Q9Y6F1672801
PARP-1, DNA and amino acid sequence determination and analysis of wild-type and mutant genesHomo sapiens-675533
gene PARP, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overviewMus musculus-672801
gene parp-1, expression in LMV cells and subclones, derived from the parental line LLC-MK2 from rhesus monkey Macaca mulatta kidney, stably expressing the estradiol-inducible transcriptional transactivation factor Gal4ERVPMus musculus-676203
trancriptional regulation, overviewMus musculus-673854
expression in Escherichia coli as a histidine-tag fusion proteinNeisseria meningitidis-659962
catalytic domain DELTAN22 and DELTAN222 mutants, expression in Escherichia coliPseudomonas aeruginosa-661051
expressed in Escherichia coli as a soluble, cytosolic His function protein, rHisExoSPseudomonas aeruginosa-661868
expression of ExoS in HeLa cells leads to a loss of phosphorylation of ERM proteins, overview, expression of wild-type and mutant ExoS in enzyme-deficient strain PA103, co-expression with 14-3-3Pseudomonas aeruginosa-672996
expression of ExoT and the isolated GAP and ADPRT enzyme domains, respectively, in A-549 cellsPseudomonas aeruginosa-676823
expression of various GST-fusion protein constructs of ExoS mutants in HeLa cellsPseudomonas aeruginosa-673573
-Trypanosoma brucei-658546

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
C19ABacillus cereus-ADP-ribosyltransferase activity is 118% of the wild-type activity658013
E185QBacillus cereus-no ADP-ribosyltransferase activity658013
Q183EBacillus cereus-no ADP-ribosyltransferase activity658013
R155EBacillus cereus-ADP-ribosyltransferase activity is 0.2% of the wild-type activity658013
R59KBacillus cereus-ADP-ribosyltransferase activity is 1.1% of the wild-type activity658013
R59K/R97KBacillus cereus-no ADP-ribosyltransferase activity658013
R97KBacillus cereus-ADP-ribosyltransferase activity is 1.9% of the wild-type activity658013
T178ABacillus cereus-ADP-ribosyltransferase activity is 1.3% of the wild-type activity658013
T178A/Q183EBacillus cereus-no ADP-ribosyltransferase activity658013
Y151VBacillus cereus-ADP-ribosyltransferase activity is 1.6% of the wild-type activity658013
Y180TBacillus cereus-no ADP-ribosyltransferase activity658013
E219QClostridium limosum-site-directed mutagenesis, inactive mutant672048
Q217EClostridium limosum-site-directed mutagenesis, the point mutation alters the asparagine-specificity of the enzyme to an arginie-specificity, the mutant does not show ADP-ribosyltransferase activity towards RhoA, but is still capable of NAD-binding and possesses NAD+ glycohydrolase activity, the mutant exoenzyme C3 is capable of ADP-ribosylation of poly-arginine, but not poly-asparagine, and shows high activity with Arg residues of soybean trypsin inhibitor672048
R151AClostridium limosum-site-directed mutagenesis, the mutation does not alter the enzyme activity or its potential as substrate for the C3 mutant Q217E672048
R61AClostridium limosum-site-directed mutagenesis, the mutation does not alter the enzyme activity or its potential as substrate for the C3 mutant Q217E672048
R86AClostridium limosum-site-directed mutagenesis, the mutation does not alter the enzyme activity but its potential as substrate for the C3 mutant Q217E, which cannot ADP-ribosylate this mutant672048
E301AClostridium perfringens-no NADase activity detected657492
F349AClostridium perfringens-the ratio of turnover-number to Km-value in the NADase reaction is 1% of the wild-type ratio. The ratio of turnover-number to Km-value in the ADP-ribosyltransferase activity is 1.9% of the wild-type ratio with rabbit muscle actin as substrate and 4% of the wild-type ratio with non-muscle actin from human platelets as substrate657492
F349YClostridium perfringens-the ratio of turnover-number to Km-value in the NADase reaction is 110% of the wild-type ratio657492
N255AClostridium perfringens-the ratio of turnover-number to Km-value in the NADase reaction is 90% of the wild-type ratio. The ratio of turnover-number to Km-value in the ADP-ribosyltransferase activity is 20% of the wild-type ratio with rabbit muscle actin as substrate and 77% of the wild-type ratio with non-muscle actin from human platelets as substrate657492
R352AClostridium perfringens-no ADP-ribosyltransferase activity with rabbit muscle actin and non-muscle actin from human platelets; the ratio of turnover-number to Km-value in the NADase reaction is 2% of the wild-type ratio, no activity657492
Y246AClostridium perfringens-the ratio of turnover-number to Km-value in the NADase reaction is 90% of the wild-type ratio. The ratio of turnover-number to Km-value in the ADP-ribosyltransferase activity is 1.9% of the wild-type ratio with rabbit muscle actin as substrate and 19% of the wild-type ratio with non-muscle actin from human platelets as substrate657492
Y251AClostridium perfringens-the ratio of turnover-number to Km-value in the NADase reaction is 10% of the wild-type ratio657492
E118AEnterobacteria phage T4P12726mutation reduces the toxicity of the enzyme and still allows small colonies to grow659054
E163AEnterobacteria phage T4P12726mutation reduces toxicity of ModA to a minor extent659054
E165AEnterobacteria phage T4P12726mutation in ModA reduces the toxicity to colony growth659054
E171AEnterobacteria phage T4P12726mutation reduces the toxicity of the enzyme and still allows small colonies to grow659054
E173AEnterobacteria phage T4P12726mutation largly abolishes enzyme activity659054
F127AEnterobacteria phage T4P12726mutation in ModA reduces the toxicity to colony growth659054
F129AEnterobacteria phage T4P12726mutation in ModA reduces the toxicity to colony growth; mutation largly abolishes enzyme activity659054
I176AEnterobacteria phage T4P12726mutation reduces the toxicity of the enzyme and still allows small colonies to grow659054
L71AEnterobacteria phage T4P12726mutation largly abolishes enzyme activity659054
N128AEnterobacteria phage T4P12726mutation reduces toxicity of ModA to a minor extent659054
N130AEnterobacteria phage T4P12726mutant enzyme with toxicity close to that of wild-type enzyme659054
Q116AEnterobacteria phage T4P12726mutation reduces toxicity of ModA to a minor extent659054
Q164AEnterobacteria phage T4P12726mutation reduces toxicity of ModA to a minor extent659054
Q172AEnterobacteria phage T4P12726mutant enzyme with toxicity close to that of wild-type enzyme659054
R72AEnterobacteria phage T4P12726mutation in ModA reduces the toxicity to colony growth659054
R73AEnterobacteria phage T4P12726mutation largly abolishes enzyme activity659054
S109AEnterobacteria phage T4P12726mutation in ModA reduces the toxicity to colony growth659054
S111AEnterobacteria phage T4P12726mutant enzyme with toxicity close to that of wild-type enzyme659054
DELTA106-288Mus musculus-mutant enzyme has NADase activity, lack of transferase activity659225
DELTA24–288Mus musculus-signal sequences necessary for export from the ER (at the amino terminus) and addition of a GPI-anchor (at the carboxyl terminus) are deleted. The resulting mutants retain the catalytic properties of the mature wild-type ART1. Their NADase activities relative to transferase activities are very low, and nicotinamide release is enhanced in the presence of the ADP-ribose acceptor, agmatine659225
A425KPseudomonas aeruginosa-site-directed mutagenesis, phenotypic analysis673573
D424APseudomonas aeruginosa-site-directed mutagenesis, phenotypic analysis673573
D424A/D427APseudomonas aeruginosa-site-directed mutagenesis, reduced interaction with 14-3-3, phenotypic analysis673573
D424A/L426A/D427A/L428APseudomonas aeruginosa-site-directed mutagenesis, the mutant shows a highly reduced expression level, phenotypic analysis673573
D427APseudomonas aeruginosa-site-directed mutagenesis, the mutant shows a reduced expression level, phenotypic analysis673573
DELTAN222Pseudomonas aeruginosa-the carboxy-terminal 222 amino acids, catalytic domain661051
DELTAN222Pseudomonas aeruginosa-carboxyl-terminal 222 amino acids of exoenzyme S, catalyzes the ADP-ribosylation of soybean trypsin inhibitor at a rate sixfold greater than rHisExoS. Relative to rHisExoS, DN222 has a similar affinity for NAD, a threefold greater affinity for soybean trypsin inhibitor, and a four- to eight-fold greater turnover number for the ADP-ribosylation of soybean trypsin inhibitor. DN222 does not chromatograph as an aggregate, which shows that the amino-terminal 99 amino acids of exoenzyme S are responsible for the aggregation phenotype661868
DELTAN222/E381APseudomonas aeruginosa-possesses 0.02% of the ADP-ribosyltransferase activity of DELTAN222. KM-value for (ADP-D-ribosyl)n-soybean-trypsin-inhibitor is 8.7fold higher than the KM-value for DELTAN222661051
DELTAN222/E381DPseudomonas aeruginosa-possesses 0.6% of the ADP-ribosyltransferase activity of DELTAN222. KM-value for (ADP-D-ribosyl)n-soybean-trypsin-inhibitor is 7.9fold higher than the KM-value for DELTAN222661051
DELTAN222/E381SPseudomonas aeruginosa-possesses 0.01% of the ADP-ribosyltransferase activity of DELTAN222. KM-value for (ADP-D-ribosyl)n-soybean-trypsin-inhibitor is 4.7fold higher than the KM-value for DELTAN222661051
DELTAN222/E387APseudomonas aeruginosa-possesses 31% of the ADP-ribosyltransferase activity of DELTAN222661051
DELTAN222/E399APseudomonas aeruginosa-possesses 28% of the ADP-ribosyltransferase activity of DELTAN222661051
DELTAN222/E414APseudomonas aeruginosa-possesses 20% of the ADP-ribosyltransferase activity of DELTAN222661051
E379DPseudomonas aeruginosa-mutation inhibits expression of ADP-ribosyltransferase activity, but has little effect on the expression of NAD glycohydrolase activity661872
E381DPseudomonas aeruginosa-mutant deficient in ADP-ribosyltransferase activity, possesses pI heterogeneity that is different than that of auto-ADP-ribosylated wild-type ExoS661065
E381DPseudomonas aeruginosa-mutation inhibits expression of both ADP-ribosyltransferase activity and NAD glycohydrolase activity661872
E381DPseudomonas aeruginosa-site-directed mutagenesis, the mutation within the active site for the ADPr domain695219
G421APseudomonas aeruginosa-site-directed mutagenesis, phenotypic analysis673573
L422APseudomonas aeruginosa-site-directed mutagenesis, phenotypic analysis673573
L423APseudomonas aeruginosa-site-directed mutagenesis, phenotypic analysis673573
L426APseudomonas aeruginosa-site-directed mutagenesis, phenotypic analysis673573
L426A/D427APseudomonas aeruginosa-site-directed mutagenesis, the mutant shows a highly reduced expression level and slightly reduced cytotoxicity, no interaction with 14-3-3, phenotypic analysis673573
L426A/D427A/L428APseudomonas aeruginosa-site-directed mutagenesis, the mutant shows a highly reduced expression level and cytotoxicity, no interaction with 14-3-3, phenotypic analysis673573
Q420APseudomonas aeruginosa-site-directed mutagenesis, phenotypic analysis673573
R146KPseudomonas aeruginosa-site-directed mutagenesis, the mutation within the active site for the RhoGAP domain695219
R146K/E379/381DPseudomonas aeruginosa-inactive mutant, does not inhibit Pseudomonas aeruginosa internalization into ExoS-transfected HeLa cells in contrast to the wild-type enzyme695219
S419IPseudomonas aeruginosa-site-directed mutagenesis, phenotypic analysis673573
Y426HPseudomonas aeruginosa-in native conformation, CRM66 shows limited ability to modify EF-2 covalently. Upon activation with urea and dithiothreitol CRM66 loses ADP-ribosylation activity entirely, yet it retains the ability to bind NAD+. Replacement of Tyr-426 with histidine in CRM66 completely restores cytotoxicity and ADP-ribosyltransferase activity662087
E189ARattus norvegicus-about 5200fold decrease in NAD+ hydrolysis activity657940
E189IRattus norvegicus-20000fold decrease in NAD+ hydrolysis activity657940
E189SRattus norvegicus-about 5200fold decrease in NAD+ hydrolysis activity657940
Q187A/E189ARattus norvegicus-50000fold decrease in NAD+ hydrolysis activity657940
Y251FClostridium perfringens-the ratio of turnover-number to Km-value in the NADase reaction is 40% of the wild-type ratio657492
additional informationDrosophila melanogaster-phenotypes of isozyme-deficient mutant mice, overview673854
Y131AEnterobacteria phage T4P12726mutation largly abolishes enzyme activity659054
additional informationHomo sapiens-stable expression of the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP, amino acids 1-547, in HEK-293 cells increases the expression of the enzyme671265
additional informationHomo sapiens-analysis of polymorphisms of PARP-1 promoter sequence in Parkinson patients, variations in the regulatory region are probably involved in increased risk for the disease, overview675533
DELTA24–293Mus musculus-signal sequences necessary for export from the ER (at the amino terminus) and addition of a GPI-anchor (at the carboxyl terminus) are deleted. The resulting mutants retain the catalytic properties of the mature wild-type ART1. Their NADase activities relative to transferase activities are very low, and nicotinamide release is enhanced in the presence of the ADP-ribose acceptor, agmatine659225
additional informationMus musculus-knockout mice show increased inflammatory response in PARP-1 -/- compared to wild-type animals, characterized by neutrophil infiltration and increased IL-6 levels in broncho-alveolar lavages, the lesions are reversible, since the extent of the hyperplastic regions is reduced after 21 days of recovery and do not result in fibrosis, phenotype, overview671255
additional informationMus musculus-effects of ADP-ribosylation of integrin alpha7 on the expression of the monoclonal anti-integrin antibody 9EG7 epitope in intact differentiated C2C12 cells in presence or absene of NAD+ and Mn2+, overview671826
additional informationMus musculus-construction of parp-1-knockout mice672809
additional informationMus musculus-PARP-1 knockout mice are viable, fertile and do not develop early onset tumors, cells isolated from these mice show an increased level of homologous recombination672969
additional informationMus musculus-phenotypes of isozyme-deficient mutant mice, overview673854
additional informationMus musculus-establishment of an immortalized PARP-1-/- murine endothelial cell line HYKO6 by transfection of primary cells with a plasmid containing the SV40 genome, expression of epitopes for detection by antibodies, phenotype, overview675022
additional informationMus musculus-PARP-1 knockout mice are much less sensitive to inflammatory stress as a result of a diminished release of pro-inflammatory mediators, including nitric oxide, parp-1 knockout mice show reduced NO-induced oxidative injury and response to genotoxic damage during carcinogenesis and inflammation675025
additional informationMus musculus-downregulatory effect of PARP-1 on the p53-dependent regulation of recombination between SV40 minichromosomes in primate cell lines conditionally expressing exogenous PARP-1 in a wild-type p53-positive or -negative background, respectively, overview676203
L428APseudomonas aeruginosa-site-directed mutagenesis, reduced interaction with 14-3-3, the mutant shows highly reduced cytotoxicity, phenotypic analysis673573
additional informationPseudomonas aeruginosa-enzyme is comprised of an N-terminal domain with GTPase activating protein activity towards Rho family GTPases and a C-terminal ADP ribosyl-transferase (ADPRT) domain with minimal activity towards a synthetic substrate in vitro. Deletion of a majority of the ADPRT domain (residues 234 to 438) or point mutations of the ADPRT catalytic site (residues 383 to 385) leads to distinct changes in host cell morphology and substantially reduces the ability of ExoT to inhibit in vitro epithelial wound healing over a 24-h period. In contrast, only subtle effects on the efficiency of ExoT-induced bacterial internalization are observed in the ADPRT mutant forms661878
additional informationPseudomonas aeruginosa-the recombinant deletion protein N223-53 which contains the catalytic domain of Exo53, comprising its 223 carboxyl-terminal residues catalyzes the FAS-dependent ADP-ribosylation of soybean trypsin inhibitor at 0.4% and of the Ras protein at 1.0% of the rates of catalysis by N222-49 (a protein comprising the 222 carboxyl-terminal residues of ExoS, which represent its catalytic domain). N223-53 possesesses binding affinities for NAD+ and SBTI similar to those of N222-49 but shows a lower rate for the ADP-ribosylation of SBTI; the recombinant deletion protein N223-53 which contains the catalytic domain of Exo53, comprising its 223 carboxyl-terminal residues catalyzes the FAS-dependent ADP-ribosylation of soybean trypsin inhibitor at 0.4% and of the Ras protein at 1.0% of the rates of catalysis by N222-49 (a protein comprising the 222 carboxyl-terminal residues of ExoS, which represent its catalytic domain). N223-53 possesesses binding affinities for NAD+ and SBTI similar to those of N222-49 but shows a lower velocity rate for the ADP-ribosylation of SBTI661986
additional informationPseudomonas aeruginosa-construction of an enzyme-deficient strain 388DELTAexoS672150
additional informationPseudomonas aeruginosa-construction of a truncated ExoS mutant DELTA51-72672996

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
analysisMus musculus-establishment of an immortalized PARP-1-/- murine endothelial cell line HYKO6 as a tool to study PARP-1-mediated endothelial cell dysfunction675022
molecular biologyMus musculus-establishment of an immortalized PARP-1-/- murine endothelial cell line HYKO6 as a tool to study PARP-1-mediated endothelial cell dysfunction675022
pharmacologyMus musculus-the enzyme inhibition is a possible tool in cancer therapy both in prophylactic and therapeutic treatment, e.g. by targeting BRCA2 tumors with PARP inhibitors, overview672969
drug developmentPseudomonas aeruginosa-the enzyme can be a target for anti-bacterial treatment694800

DISEASETITLE OF PUBLICATIONLINK TO PUBMED
AcidosisActivation of poly(ADP-ribose) polymerase in severe hemorrhagic shock and resuscitation. PubMed
Acquired Immunodeficiency SyndromePharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents. PubMed
Acute Kidney InjuryEffect of poly(ADP-ribose) polymerase inhibition on outer medullary hypoxic damage. PubMed
Acute Kidney InjuryInhibition of Poly(ADP-Ribose) Polymerase Attenuates Acute Kidney Injury in Sodium Taurocholate-Induced Acute Pancreatitis in Rats. PubMed
Acute Kidney InjuryInhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats. PubMed
Acute Kidney InjuryPoly (ADP-ribose) polymerase as a potential target for the treatment of acute renal injury caused by lipopolysaccharide. PubMed
Acute Kidney InjuryPoly(ADP-ribose) polymerase-1 gene ablation protects mice from ischemic renal injury. PubMed
Acute Kidney InjuryPoly(ADP-ribose) polymerase-mediated cell injury in acute renal failure. PubMed
Acute Kidney InjuryRole of the poly(ADP-ribose)polymerase activity in vancomycin-induced renal injury. PubMed
Acute Lung InjuryInflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury. PubMed
Acute Lung InjuryInhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. PubMed
Acute Lung InjuryMurine strain differences in acute lung injury and activation of poly(ADP-ribose) polymerase by in vitro exposure of lung slices to bleomycin. PubMed
Acute Lung InjuryRole of PARP on iNOS pathway during endotoxin-induced acute lung injury. PubMed
AdenocarcinomaAdenosine diphosphate ribosyl transferase and x-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer. PubMed
AdenocarcinomaAntiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells. PubMed
AdenocarcinomaBax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy. PubMed
AdenocarcinomaCompromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. PubMed
AdenocarcinomaCyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis. PubMed
AdenocarcinomaDual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells. PubMed
AdenocarcinomaErucin, a new promising cancer chemopreventive agent from rocket salads, shows anti-proliferative activity on human lung carcinoma A549 cells. PubMed
AdenocarcinomaEvaluation of apoptosis induction using PARP cleavage on gastric adenocarcinoma and fibroblast cell lines by different strains of Helicobacter pylori. PubMed
AdenocarcinomaFish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo. PubMed
AdenocarcinomaHigh nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer. PubMed
AdenocarcinomaParp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. PubMed
AdenocarcinomaProdigiosin-induced apoptosis in human colon cancer cells. PubMed
AdenocarcinomaProtein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures. PubMed
AdenocarcinomaPTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors. PubMed
AdenocarcinomaSanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion. PubMed
AdenocarcinomaZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. PubMed
AdenomaEffects of cumene hydroperoxide on adenosine diphosphate ribosyl transferase in mononuclear leukocytes of patients with adenomatous polyps in the colon. PubMed
AdenomaFish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo. PubMed
AdenomaOverexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis. PubMed
AdenomaParp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. PubMed
AdenomaPoly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. PubMed
AdenomaSuppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ mice. PubMed
Adenomatous Polyposis ColiAbsence of stimulation of poly(ADP-ribose) polymerase activity in patients predisposed to colon cancer. PubMed
Adenomatous Polyposis ColiPoly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. PubMed
Adrenal Cortex NeoplasmsBitter Melon (Momordica charantia) Extract Suppresses Adrenocortical Cancer Cell Proliferation Through Modulation of the Apoptotic Pathway, Steroidogenesis, and Insulin-Like Growth Factor Type 1 Receptor/RAC-? Serine/Threonine-Protein Kinase Signaling. PubMed
AlbuminuriaTempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus. PubMed
Alzheimer DiseaseAlzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose) polymerase activity in the hippocampus. PubMed
Alzheimer DiseaseBeta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. PubMed
Alzheimer DiseaseEvaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease. PubMed
Alzheimer DiseaseIncreased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease. PubMed
Alzheimer DiseaseInteraction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk. PubMed
Alzheimer DiseasePoly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease. PubMed
Alzheimer DiseasePolyADP-ribosylation is involved in neurotrophic activity. PubMed
Alzheimer DiseaseThe role of poly(ADP-ribose) polymerase-1 in CNS disease. PubMed
Amyotrophic Lateral SclerosisLow levels of selenium compounds are selectively toxic for a human neuron cell line through ROS/RNS increase and apoptotic process activation. PubMed
Amyotrophic Lateral SclerosisPARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients. PubMed
Amyotrophic Lateral SclerosisReactive astrocytes express PARP in the central nervous system of SOD(G93A) transgenic mice. PubMed
AnemiaErythropoietin-driven signalling and cell migration mediated by polyADP-ribosylation. PubMed
AneurysmClinical perspectives of PARP inhibitors. PubMed
AneurysmPharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: future directions. PubMed
Angina, UnstableActivation and overexpression of PARP-1 in circulating mononuclear cells promote TNF-alpha and IL-6 expression in patients with unstable angina. PubMed
AngiomyolipomaHuman TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress. PubMed
AnthraxCaspase- and p53-dependent apoptosis in breast carcinoma cells induced by a synthetic selenadiazole derivative. PubMed
Antiphospholipid SyndromePoly(ADP-ribose) polymerase alleles in French Caucasians are associated neither with lupus nor with primary antiphospholipid syndrome. GRAID Research Group. Group for Research on Auto-Immune Disorders. PubMed
Aortic Valve StenosisIncreased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity. PubMed
ArthritisInhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy. PubMed
ArthritisModulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase. PubMed
ArthritisPartial protection against collagen antibody-induced arthritis in PARP-1 deficient mice. PubMed
ArthritisPoly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus. PubMed
ArthritisPoly(ADP-ribose) polymerase inhibitors. PubMed
ArthritisProtection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase. PubMed
ArthritisStructure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. PubMed
ArthritisTherapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response. PubMed
Arthritis, ExperimentalSynergistic effects of thalidomide and poly (ADP-ribose) polymerase inhibition on type II collagen-induced arthritis in mice. PubMed
Arthritis, ExperimentalTherapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response. PubMed
Arthritis, RheumatoidA poly(ADP-ribose) polymerase haplotype spanning the promoter region confers susceptibility to rheumatoid arthritis. PubMed
Arthritis, RheumatoidLack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population. PubMed
Arthritis, RheumatoidPARP inhibitors: New partners in the therapy of cancer and inflammatory diseases. PubMed
Arthritis, RheumatoidPartial protection against collagen antibody-induced arthritis in PARP-1 deficient mice. PubMed
Arthritis, RheumatoidPoly(ADP-ribose) polymerase inhibition reduces tumor necrosis factor-induced inflammatory response in rheumatoid synovial fibroblasts. PubMed
Arthritis, RheumatoidPoly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. PubMed
Arthritis, RheumatoidThe Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients. PubMed
Arthritis, RheumatoidTherapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response. PubMed
AsbestosisPoly(ADP-ribosyl)ation in asthma and other lung diseases. PubMed
AsthmaAsthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis. PubMed
AsthmaEffects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma. PubMed
AsthmaGene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma. PubMed
AsthmaIncreased poly(ADP-ribose) polymerase (PARP)-1 expression and activity are associated with inflammation but not goblet cell metaplasia in murine models of allergen-induced airway inflammation. PubMed
AsthmaInhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs. PubMed
AsthmaPARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model. PubMed
AsthmaPARP-1: a new player in the asthma field? PubMed
AsthmaPoly(ADP-ribosyl)ation in asthma and other lung diseases. PubMed
AsthmaThe Ala allele at Val762Ala polymorphism in poly(ADP-ribose) polymerase-1 (PARP-1) gene is associated with a decreased risk of asthma in a Turkish population. PubMed
AstrocytomaComparative status of activated ERK1/2 and PARP cleavage in human gliomas. PubMed
AstrocytomaInhibition of Mer and Axl Receptor Tyrosine Kinases in Astrocytoma Cells Leads to Increased Apoptosis and Improved Chemosensitivity. PubMed
Ataxiap53 Activation by nitric oxide involves down-regulation of Mdm2. PubMed
Ataxia TelangiectasiaEnhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. PubMed
Ataxia TelangiectasiaIdentification of proteins in the hamster DNA end-binding complex. PubMed
Ataxia TelangiectasiaInhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks. PubMed
Ataxia TelangiectasiaIntroductory review: involvement of ADP-ribosylation in cellular recovery from some forms of DNA damage. PubMed
Ataxia TelangiectasiaMonitoring and signaling of radiation-induced damage in mammalian cells. PubMed
Ataxia TelangiectasiaPoly(ADP-ribose) polymerase activity is not affected in ataxia telangiectasia cells and knockout mice. PubMed
Ataxia TelangiectasiaRole of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1. PubMed
Ataxia TelangiectasiaS-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells. PubMed
Ataxia TelangiectasiaTargeted cancer therapies based on the inhibition of DNA strand break repair. PubMed
Ataxia TelangiectasiaThe DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication. PubMed
Ataxia TelangiectasiaThe inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells. PubMed
AtherosclerosisActivation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging. PubMed
AtherosclerosisDifferential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability. PubMed
AtherosclerosisOpposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. PubMed
AtherosclerosisPARP inhibition in atherosclerosis and its effects on dendritic cells, T cells and auto-antibody levels. PubMed
AtherosclerosisPARP1 is required for adhesion molecule expression in atherogenesis. PubMed
AtherosclerosisPoly (ADP-Ribose) Polymerase Inhibition Attenuates Atherosclerotic Plaque Development in ApoE-/- Mice with Hyperhomocysteinemia. PubMed
AtherosclerosisPoly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. PubMed
AtherosclerosisPoly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. PubMed
AtherosclerosisRole of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. PubMed
AtherosclerosisRole of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. PubMed
AtherosclerosisThieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content. PubMed
Autoimmune DiseasesApoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin. PubMed
Autoimmune DiseasesAutoantibodies to Poly(ADP-Ribose) Polymerase in Centenarians: A Reappraisal of Grabar's Hypothesis. PubMed
Autoimmune DiseasesPARP activity and NAD concentration in PMC from patients affected by systemic sclerosis and lupus erythematosus. PubMed
Autoimmune DiseasesPoly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator. PubMed
Autoimmune DiseasesPoly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. PubMed
Autoimmune DiseasesRoles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications. PubMed
BlisterActivation of poly [ADP-Ribose] polymerase in endothelial cells and keratinocytes: role in an in vitro model of sulfur mustard-mediated vesication. PubMed
BlisterInvolvement of small GTPases Rho and Rac in the invasion of rat ascites hepatoma cells. PubMed
BlisterPARP determines the mode of cell death in skin fibroblasts, but not keratinocytes, exposed to sulfur mustard. PubMed
BlisterPutative role of proteolysis and inflammatory response in the toxicity of nerve and blister chemical warfare agents: implications for multi-threat medical countermeasures. PubMed
Bone ResorptionRho-A is critical for osteoclast podosome organization, motility, and bone resorption. PubMed
Bone ResorptionRole of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis. PubMed
Bone ResorptionThe small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts. PubMed
Brain DeathActivation and modulation of cardiac poly-adenosine diphosphate ribose polymerase activity in a rat model of brain death. PubMed
Brain DiseasesPoly(ADP-ribosyl)ation enhancement in brain cell nuclei is associated with diabetic neuropathy. PubMed
Brain EdemaContribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats. PubMed
Brain EdemaPoly(ADP-ribose) polymerase activation and brain edema formation by hemoglobin after intracerebral hemorrhage in rats. PubMed
Brain EdemaPoly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia: its role in brain edema and cell death. PubMed
Brain InjuriesA dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3gamma. PubMed
Brain InjuriesA novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. PubMed
Brain InjuriesAcute Meningitis. PubMed
Brain InjuriesAt the scene of ischemic brain injury: is PARP a perp? PubMed
Brain InjuriesBeneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat. PubMed
Brain InjuriesBiphasic changes in the levels of poly(ADP-ribose) polymerase-1 and caspase 3 in the immature brain following hypoxia-ischemia. PubMed
Brain InjuriesContribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats. PubMed
Brain InjuriesDirect phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. PubMed
Brain InjuriesDrug-induced hypothermia begun 5 minutes after injury with a poly(adenosine 5'-diphosphate-ribose) polymerase inhibitor reduces hypoxic brain injury in rat pups. PubMed
Brain InjuriesEffect of Acute Poly(ADP-Ribose) Polymerase Inhibition by 3-AB on Blood-Brain Barrier Permeability and Edema Formation After Focal Traumatic Brain Injury in Rats. PubMed
Brain InjuriesEffects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains. PubMed
Brain InjuriesEnhanced poly(ADP-ribose) polymerase-1 activation contributes to recombinant tissue plasminogen activator-induced aggravation of ischemic brain injury in vivo. PubMed
Brain InjuriesIdentification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury. PubMed
Brain InjuriesIncreased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection. PubMed
Brain InjuriesInfluence of PARP-1 polymorphisms in patients after traumatic brain injury. PubMed
Brain InjuriesInhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide. PubMed
Brain InjuriesInhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy. PubMed
Brain InjuriesInteraction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury. PubMed
Brain InjuriesIschemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. PubMed
Brain InjuriesLocal administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice. PubMed
Brain InjuriesMicroglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor. PubMed
Brain InjuriesNAD+ and NADH in ischemic brain injury. PubMed
Brain InjuriesNAD+ Metabolism and NAD+-Dependent Enzymes: Promising Therapeutic Targets for Neurological Diseases. PubMed
Brain InjuriesNeuroprotective effects of KCL-440, a new poly(ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model. PubMed
Brain InjuriesOxidative Stress and NAD(+) in Ischemic Brain Injury: Current Advances and Future Perspectives. PubMed
Brain InjuriesOxidative stress in bacterial meningitis. PubMed
Brain InjuriesPARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma. PubMed
Brain InjuriesPARP-1 gene disruption in mice preferentially protects males from perinatal brain injury. PubMed
Brain InjuriesPharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats. PubMed
Brain InjuriesPoly(ADP ribose) polymerase cleavage precedes neuronal death in the hippocampus and cerebellum following injury to the developing rat forebrain. PubMed
Brain InjuriesPoly(ADP-ribose) polymerase-1 and its clinical applications in brain injury. PubMed
Brain InjuriesPoly(ADP-ribosyl)ation and stroke. PubMed
Brain InjuriesPostnatal Age Influences Hypoglycemia-induced Poly(ADP-ribose) Polymerase-1 Activation in the Brain Regions of Rats. PubMed
Brain InjuriesProtective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. PubMed
Brain InjuriesReduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase. PubMed
Brain InjuriesSex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke. PubMed
Brain InjuriesTemporal patterns of poly(ADP-ribose) polymerase activation in the cortex following experimental brain injury in the rat. PubMed
Brain InjuriesTraumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report. PubMed
Brain Injuries[Involvement of caspase on apoptosis in ischemia-induced neuronal cell death: usefulness of caspase inhibitors for stroke therapy] PubMed
Brain Injuries[Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase] PubMed
Brain Ischemia3-Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice. PubMed
Brain IschemiaA newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. PubMed
Brain IschemiaA novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. PubMed
Brain IschemiaAnti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. PubMed
Brain IschemiaApoptosis-inducing factor triggered by poly(ADP-Ribose) polymerase and bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. PubMed
Brain IschemiaCellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair. PubMed
Brain IschemiaCombined therapy with PJ34, a poly(ADP-ribose)polymerase inhibitor, reduces tissue plasminogen activator-induced hemorrhagic transformations in cerebral ischemia in mice. PubMed
Brain IschemiaComet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors. PubMed
Brain IschemiaContributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia. PubMed
Brain IschemiaDifferential PARP Cleavage: An Indication of Heterogeneous Forms of Cell Death and Involvement of Multiple Proteases in the Infarct of Focal Cerebral Ischemia in Rat. PubMed
Brain IschemiaEffect of 3-aminobenzamide, PARP inhibitor, on matrix metalloproteinase-9 level in plasma and brain of ischemic stroke model. PubMed
Brain IschemiaEnhanced poly(ADP-ribose) polymerase-1 activation contributes to recombinant tissue plasminogen activator-induced aggravation of ischemic brain injury in vivo. PubMed
Brain IschemiaEnhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain. PubMed
Brain IschemiaInhibition of poly(ADP-ribose) polymerase: reduction of ischemic injury and attenuation of N-methyl-D-aspartate-induced neurotransmitter dysregulation. PubMed
Brain IschemiaInteraction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury. PubMed
Brain IschemiaIschemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection. PubMed
Brain IschemiaMitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation. PubMed,  PubMed
Brain IschemiaNatural Inhibitors of Poly(ADP-ribose) Polymerase-1. PubMed
Brain IschemiaNeuroprotective effects of a novel water-soluble poly(ADP-ribose) polymerase-1 inhibitor, MP-124, in in vitro and in vivo models of cerebral ischemia. PubMed
Brain IschemiaNeuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. PubMed
Brain IschemiaNeuroprotective Properties of Picroside II in a Rat Model of Focal Cerebral Ischemia. PubMed
Brain IschemiaNMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase. PubMed
Brain IschemiaNovel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia. PubMed
Brain IschemiaOxidative Stress and NAD(+) in Ischemic Brain Injury: Current Advances and Future Perspectives. PubMed
Brain IschemiaOxidative stress in brain ischemia. PubMed
Brain IschemiaPARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. PubMed
Brain IschemiaPathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation. PubMed
Brain IschemiaPoly (ADP-ribose) polymerase-1 initiated neuronal cell death pathway--do androgens matter? PubMed
Brain IschemiaPoly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. PubMed
Brain IschemiaPoly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke. PubMed
Brain IschemiaPoly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia. PubMed
Brain IschemiaPoly(ADP-Ribose)-Polymerase-Catalyzed Hydrolysis of NAD(+): QM/MM Simulation of the Enzyme Reaction. PubMed
Brain IschemiaPoly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage. PubMed
Brain IschemiaPoly(ADP-ribosyl)ation and stroke. PubMed
Brain IschemiaPost-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia. PubMed
Brain IschemiaProtective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. PubMed
Brain IschemiaReduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in mice. PubMed
Brain IschemiaRole of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia. PubMed
Brain IschemiaSex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke. PubMed
Brain IschemiaSPATIAL AND FUNCTIONAL RELATIONSHIP BETWEEN POLY(ADP-RIBOSE) POLYMERASE-1 AND POLY(ADP-RIBOSE) GLYCOHYDROLASE IN THE BRAIN. PubMed
Brain IschemiaThe effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase. PubMed
Brain IschemiaThe neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia. PubMed
Brain IschemiaTowards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors. PubMed
Brain Ischemia[Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase] PubMed
Brain NeoplasmsBrain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors. PubMed
Brain NeoplasmsChemopotentiation by PARP inhibitors in cancer therapy. PubMed
Brain NeoplasmsDNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. PubMed
Brain NeoplasmsNull mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice. PubMed
Brain NeoplasmsPARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. PubMed
Brain NeoplasmsTargeted Therapy for Brain Tumours: Role of PARP Inhibitors. PubMed
Brain NeoplasmsThe potential role and application of PARP inhibitors in cancer treatment. PubMed
Brain NeoplasmsWhole-body hyperthermia and ADPRT inhibition in experimental treatment of brain tumors. PubMed
Breast DiseasesPoly(ADP-ribose) polymerase in human breast cancer: a case-control analysis. PubMed
Breast Neoplasms4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells. PubMed
Breast Neoplasms4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. PubMed
Breast NeoplasmsA marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer. PubMed
Breast NeoplasmsA population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. PubMed
Breast NeoplasmsA review of triple-negative breast cancer. PubMed
Breast NeoplasmsA selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors. PubMed
Breast NeoplasmsActivation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells. PubMed
Breast NeoplasmsActivation of choline kinase by extracellular Ca2+ is Ca(2+)-sensing receptor, Galpha12 and Rho-dependent in breast cancer cells. PubMed
Breast NeoplasmsAnalysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients. PubMed
Breast NeoplasmsAnti-miR-203 Upregulates SOCS3 Expression in Breast Cancer Cells and Enhances Cisplatin Chemosensitivity. PubMed
Breast NeoplasmsAntitumor and anticancer stem cell activity of a poly ADP-ribose polymerase inhibitor olaparib in breast cancer cells. PubMed
Breast NeoplasmsAutocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. PubMed
Breast NeoplasmsBCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death. PubMed
Breast NeoplasmsBiPar Sciences presents interim phase 2 results for PARP inhibitor BSI-201 at San Antonio Breast Cancer Symposium. PubMed
Breast NeoplasmsBisphosphonates induce apoptosis in human breast cancer cell lines. PubMed
Breast NeoplasmsBitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apoptosis. PubMed
Breast NeoplasmsBlockade of MUC1 expression by glycerol guaiacolate inhibits proliferation of human breast cancer cells. PubMed
Breast NeoplasmsBRCA1-methylated sporadic breast cancers are BRCA-like in showing a basal phenotype and absence of ER expression. PubMed
Breast NeoplasmsBRCA2-Deficient CAPAN-1 Cells are Extremely Sensitive to the Inhibition of Poly (ADP-Ribose) Polymerase: An Issue of Potency. PubMed
Breast NeoplasmsBufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway. PubMed
Breast NeoplasmsCan patients with metastatic breast cancer be cured after introduction of newer and more effective agents? PubMed
Breast NeoplasmsCapsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. PubMed
Breast NeoplasmsCDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells. PubMed
Breast NeoplasmsChromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. PubMed
Breast NeoplasmsCo-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy. PubMed
Breast NeoplasmsCombining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for a mouse model of BRCA1-related breast cancer. PubMed
Breast NeoplasmsCordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP. PubMed
Breast NeoplasmsCurrent Issues of Targeted Therapy in Metastatic Triple-Negative Breast Cancer. PubMed
Breast NeoplasmsCurrent Status of Poly(ADP-ribose) Polymerase Inhibitors as Novel Therapeutic Agents for Triple-Negative Breast Cancer. PubMed
Breast NeoplasmsCytoplasmic poly(adenosine diphosphate-ribose) polymerase expression is predictive and prognostic in patients with breast cancer treated with neoadjuvant chemotherapy. PubMed
Breast NeoplasmsDefective repair of oxidative dna damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase. PubMed
Breast NeoplasmsDeficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition. PubMed
Breast NeoplasmsDetection of heterogeneity of apoptotic fragments of poly (ADP-ribose) polymerase in MDA-MB-468 breast cancer cells: two-dimensional gel analysis. PubMed
Breast NeoplasmsDevelopment of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer. PubMed
Breast NeoplasmsDifferential anti-proliferative activities of poly(ADP-ribose) polymerase (PARP) inhibitors in triple-negative breast cancer cells. PubMed
Breast NeoplasmsDisparity in the induction of glutathione depletion, ROS formation, poly(ADP-ribose) polymerase-1 activation, and apoptosis by quinonoid derivatives of naphthalene in human cultured cells. PubMed
Breast NeoplasmsErythropoietin-driven signalling and cell migration mediated by polyADP-ribosylation. PubMed
Breast NeoplasmsEvidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis. PubMed
Breast NeoplasmsGamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells. PubMed
Breast NeoplasmsgammaH2AX and cleaved PARP-1 as apoptotic markers in irradiated breast cancer BT474 cellular spheroids. PubMed
Breast NeoplasmsGene 33 inhibits apoptosis of breast cancer cells and increases poly(ADP-ribose) polymerase expression. PubMed
Breast NeoplasmsGenetic polymorphisms in base-excision repair pathway genes and risk of breast cancer. PubMed
Breast NeoplasmsGenetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer. PubMed
Breast NeoplasmsGenetic sequence variations and ADPRT haplotype analysis in French Canadian families with high risk of breast cancer. PubMed
Breast NeoplasmsGermline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer. PubMed
Breast NeoplasmsGlobal analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells. PubMed
Breast NeoplasmsHaploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality. PubMed
Breast NeoplasmsHDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2-overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance. PubMed
Breast NeoplasmsHepatocyte growth factor/scatter factor blocks the mitochondrial pathway of apoptosis signaling in breast cancer cells. PubMed
Breast NeoplasmsHER2 Overexpression Renders Human Breast Cancers Sensitive to PARP Inhibition Independently of Any Defect in Homologous Recombination DNA Repair. PubMed
Breast NeoplasmsHigh sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. PubMed
Breast NeoplasmsHigher cytoplasmic and nuclear poly(ADP-ribose) polymerase expression in familial than in sporadic breast cancer. PubMed
Breast NeoplasmsHighlights of the Chemotherapy Foundation Symposium XXVII: therapeutic options for breast cancer. PubMed
Breast NeoplasmsInducing Synthetic Lethality using PARP Inhibitors. PubMed
Breast NeoplasmsInduction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047. PubMed
Breast NeoplasmsInduction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells. PubMed
Breast NeoplasmsInduction of ROS formation, poly(ADP-ribose) polymerase-1 activation, and cell death by PCB126 and PCB153 in human T47D and MDA-MB-231 breast cancer cells. PubMed
Breast NeoplasmsInhibition of poly(ADP)-ribose polymerase as a therapeutic strategy for breast cancer. PubMed
Breast NeoplasmsINO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin. PubMed
Breast NeoplasmsInterleukin 4 inhibits growth and induces apoptosis in human breast cancer cells. PubMed
Breast NeoplasmsIonizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance. PubMed
Breast NeoplasmsLysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis. PubMed
Breast NeoplasmsMetabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer. PubMed
Breast NeoplasmsMetal-Based Inhibition of Poly(ADP-ribose) Polymerase - The Guardian Angel of DNA. PubMed
Breast NeoplasmsMetformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. PubMed
Breast NeoplasmsMethylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad. PubMed
Breast NeoplasmsMGMT Inhibition Restores ER? Functional Sensitivity to Anti-Estrogen Therapy. PubMed
Breast NeoplasmsMutant p53 mediates survival of breast cancer cells. PubMed
Breast NeoplasmsNonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. PubMed
Breast NeoplasmsNovel targeted therapeutics: inhibitors of MDM2, ALK and PARP. PubMed
Breast NeoplasmsNuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. PubMed
Breast NeoplasmsON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells. PubMed
Breast NeoplasmsOral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. PubMed
Breast NeoplasmsOxidative stress, DNA repair, and cancer susceptibility. PubMed
Breast Neoplasmsp38? mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer. PubMed
Breast NeoplasmsPARP inhibition in breast cancer. PubMed
Breast NeoplasmsPARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells. PubMed
Breast NeoplasmsPARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis. PubMed
Breast NeoplasmsPARP inhibitor development for systemic cancer targeting. PubMed
Breast NeoplasmsPARP inhibitor treatment in ovarian and breast cancer. PubMed
Breast NeoplasmsPARP inhibitors and the treatment of breast cancer: beyond BRCA1/2? PubMed
Breast NeoplasmsPARP inhibitors and their evolving role in breast cancer. PubMed
Breast NeoplasmsPARP Inhibitors for the Treatment and Prevention of Breast Cancer. PubMed
Breast NeoplasmsPARP inhibitors in BRCA1/BRCA2 germline mutation carriers with ovarian and breast cancer. PubMed
Breast NeoplasmsPARP Inhibitors in Breast Cancer. PubMed
Breast NeoplasmsPARP inhibitors in breast cancer: BRCA and beyond. PubMed
Breast NeoplasmsPARP inhibitors in cancer therapy: promise, progress, and puzzles. PubMed
Breast NeoplasmsPARP inhibitors in cancer therapy: two modes of attack on the cancer cell widening the clinical applications. PubMed
Breast NeoplasmsPARP inhibitors stumble in breast cancer. PubMed
Breast NeoplasmsPARP inhibitors--current status and the walk towards early breast cancer. PubMed
Breast NeoplasmsPARP regulates TGF-beta receptor type II expression in estrogen receptor-positive breast cancer cell lines. PubMed
Breast NeoplasmsPARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy. PubMed
Breast NeoplasmsPARP-1 inhibitors: a novel genetically specific agents for cancer therapy. PubMed
Breast NeoplasmsPARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers? PubMed
Breast NeoplasmsPeriod-2: a tumor suppressor gene in breast cancer. PubMed
Breast NeoplasmsPI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA proficient triple negative breast cancer to PARP inhibition. PubMed
Breast NeoplasmsPoly (ADP-ribose) polymerase (PARP): rationale, preclinical and clinical evidences of its inhibition as breast cancer treatment. PubMed
Breast NeoplasmsPoly (ADP-ribose) polymerase-1 Inhibition: Preclinical and Clinical Development of Synthetic Lethality. PubMed
Breast NeoplasmsPoly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors. PubMed
Breast NeoplasmsPoly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences. PubMed
Breast NeoplasmsPoly(ADP-ribose) polymerase gene expression status and genomic instability in human breast cancer. PubMed
Breast NeoplasmsPoly(ADP-ribose) polymerase in human breast cancer: a case-control analysis. PubMed
Breast NeoplasmsPoly(ADP-Ribose) polymerase inhibition: 'Targeted' therapy for triple-negative breast cancer. PubMed
Breast NeoplasmsPoly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer? PubMed
Breast NeoplasmsPoly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors. PubMed
Breast NeoplasmsPoly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer. PubMed
Breast NeoplasmsPoly(ADP-ribose) polymerase-1 mRNA expression in human breast cancer: a meta-analysis. PubMed
Breast NeoplasmsPoly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice. PubMed
Breast NeoplasmsPolygenic model of DNA repair genetic polymorphisms in human breast cancer risk. PubMed
Breast NeoplasmsPolymorphisms of ADPRT Val762Ala and XRCC1 Arg399Glu and risk of breast cancer in Chinese women: a case control analysis. PubMed
Breast NeoplasmsRare mutations in XRCC2 increase the risk of breast cancer. PubMed
Breast NeoplasmsRecent developments in treatment stratification for metastatic breast cancer. PubMed
Breast NeoplasmsResponse of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition. PubMed
Breast NeoplasmsResveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3-dependent pathway. PubMed
Breast NeoplasmsResveratrol-induced growth inhibition in MDA-MB-231 breast cancer cells is associated with mitogen-activated protein kinase signaling and protein translation. PubMed
Breast NeoplasmsRole of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1. PubMed
Breast NeoplasmsSensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan. PubMed
Breast NeoplasmsStumbling blocks on the path to personalized medicine in breast cancer: the case of PARP inhibitors for BRCA1/2-associated cancers. PubMed
Breast NeoplasmsSulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. PubMed
Breast NeoplasmsSynergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-Ribose) polymerase inhibition, gemcitabine, and cisplatin. PubMed
Breast NeoplasmsSynthetic lethal targeting of PTEN mutant cells with PARP inhibitors. PubMed
Breast NeoplasmsSynthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells. PubMed
Breast NeoplasmsTamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells. PubMed
Breast NeoplasmsTanshinone IIA Induces Mitochondria Dependent Apoptosis in Prostate Cancer Cells in Association with an Inhibition of Phosphoinositide 3-Kinase/AKT Pathway. PubMed
Breast NeoplasmsTargeted therapy of metastatic breast cancer. PubMed
Breast NeoplasmsTargeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-ribose) polymerase inhibition. PubMed
Breast NeoplasmsTargeting DNA repair in breast cancer: A clinical and translational update. PubMed
Breast NeoplasmsThe emerging potential of poly(ADP-ribose) polymerase inhibitors in the treatment of breast cancer. PubMed
Breast NeoplasmsThe expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome. PubMed
Breast NeoplasmsThe Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors. PubMed
Breast NeoplasmsThe potential of PARP inhibitors in genetic breast and ovarian cancers. PubMed
Breast NeoplasmsThe role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes. PubMed
Breast NeoplasmsThe triple-negative subtype: new ideas for the poorest prognosis breast cancer. PubMed
Breast NeoplasmsThe tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange. PubMed
Breast NeoplasmsTherapeutic potential of PARP inhibitors for metastatic breast cancer. PubMed
Breast NeoplasmsTosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23. PubMed
Breast NeoplasmsTriple-negative breast cancer and Poly(ADP-ribose) polymerase inhibitors. PubMed
Breast NeoplasmsTriple-negative breast cancer: molecular features, pathogenesis, treatment and current lines of research. PubMed
Breast NeoplasmsUpregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types. PubMed
Breast Neoplasms[Breakthrough breast cancer treatment--PARP inhibitor, BRCA, and triple negative breast cancer] PubMed
Breast Neoplasms[PARP inhibitors and breast cancer: update and perspectives]. PubMed
Breast Neoplasms[PARP inhibitors--theoretical basis and clinical application]. PubMed
Burkitt LymphomaBiological Effects of MC2050, a Quinazoline-Based PARP-1 Inhibitor, in Human Neuroblastoma and EBV-Positive Burkitt's Lymphoma Cells. PubMed
Burkitt LymphomaChromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. PubMed
Burkitt LymphomaProlongation of the p53 response to DNA strand breaks in cells depleted of PARP by antisense RNA expression. PubMed
Burkitt LymphomaSynthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents. PubMed
Burkitt LymphomaThe antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma. PubMed
Carcinoid TumorMG-132 Inhibits Carcinoid Growth and Alters the Neuroendocrine Phenotype. PubMed
Carcinoma2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress, DNA strand breaks, and poly(ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines. PubMed
Carcinoma2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the induction of DNA strand breaks and poly(ADP-ribose) polymerase-1 activation by 17beta-estradiol in human breast carcinoma cells through alteration of CYP1A1 and CYP1B1 expression. PubMed
CarcinomaAntimicrobial cyclic decapeptides with anticancer activity. PubMed
CarcinomaAssessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma. PubMed
CarcinomaBax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy. PubMed
CarcinomaBRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. PubMed
Carcinomac-Abl Is an Upstream Regulator of Acid Sphingomyelinase in Apoptosis Induced by Inhibition of Integrins ?v?3 and ?v?5. PubMed
Carcinomac-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-{beta}-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells. PubMed
CarcinomaCaspase- and p53-dependent apoptosis in breast carcinoma cells induced by a synthetic selenadiazole derivative. PubMed
CarcinomaCell-cycle progression and response of germ cell tumors to cisplatin in vitro. PubMed
CarcinomaCharacterization of MVP and VPARP assembly into vault ribonucleoprotein complexes. PubMed
CarcinomaChemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. PubMed
CarcinomaComparative evaluation of antiproliferative, antiangiogenic and apoptosis inducing potential of black tea polyphenols in the hamster buccal pouch carcinogenesis model. PubMed
CarcinomaDeletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas. PubMed
CarcinomaDifferential radiosensitization by the poly(ADP-ribose) transferase inhibitor 3-aminobenzamide in human tumor cells of varying radiosensitivity. PubMed
CarcinomaDiscovery and Structure-Activity Relationships of Modified Salicylanilides as Cell Permeable Inhibitors of Poly(ADP-ribose) Glycohydrolase (PARG). PubMed
CarcinomaDNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. PubMed
CarcinomaEffect of Poly (ADP-ribose) Polymerase-1 Inhibition on the Proliferation of Murine Colon Carcinoma CT26 Cells. PubMed
CarcinomaEvidence for the efficacy of Iniparib, a PARP-1 inhibitor, in BRCA2-associated pancreatic cancer. PubMed
CarcinomaEvidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis. PubMed
CarcinomaExpression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV). PubMed
CarcinomaExpression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas. PubMed
CarcinomaExpression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas. PubMed
CarcinomaFlavone inhibition of tumor growth via apoptosis in vitro and in vivo. PubMed
CarcinomaGalectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family. PubMed
CarcinomaGenetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. PubMed
CarcinomaHuman sodium-iodide symporter (hNIS) gene expression is inhibited by a trans-active transcriptional repressor, NIS-repressor, containing PARP-1 in thyroid cancer cells. PubMed
CarcinomaIdentification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. PubMed
CarcinomaImidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. PubMed
CarcinomaIncreased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints. PubMed
CarcinomaInhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma. PubMed
CarcinomaInhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft. PubMed
CarcinomaIntrinsic presence of poly (ADP-ribose) is significantly increased in malignant prostate compared to benign prostate cell lines. PubMed
CarcinomaLevels of superoxide dismutases, glutathione, and poly(ADP-ribose) polymerase in radioresistant human KB carcinoma cell line. PubMed
CarcinomaMale rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity. PubMed
CarcinomaMBP-1 mediated apoptosis involves cytochrome c release from mitochondria. PubMed
CarcinomaMitochondrial DNA depletion reduces PARP-1 levels and promotes progression of the neoplastic phenotype in prostate carcinoma. PubMed
CarcinomaNovel synthetic triterpenoid methyl 25-hydroxy-3-oxoolean-12-en-28-oate induces apoptosis through JNK and p38 MAPK pathways in human breast adenocarcinoma MCF-7 cells. PubMed
CarcinomaNuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. PubMed
CarcinomaOverexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer. PubMed
CarcinomaPARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma. PubMed
CarcinomaParp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. PubMed
CarcinomaPARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy. PubMed
CarcinomaPARP-1 Val762Ala polymorphism is associated with reduced risk of non-Hodgkin lymphoma in Korean males. PubMed
CarcinomaPARP-1 Val762Ala polymorphism is associated with risk of cervical carcinoma. PubMed
CarcinomaPharmacological Inhibition of Poly(ADP-ribose) Polymerase (PARP) Activity in PARP-1 Silenced Tumour Cells Increases Chemosensitivity to Temozolomide and to a N3-Adenine Selective Methylating Agent. PubMed
CarcinomaPharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent. PubMed
CarcinomaPK11195, an isoquinoline carboxamide ligand of the mitochondrial benzodiazepine receptor, increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro. PubMed
CarcinomaPoly(adenosine diphosphate-ribose) polymerase expression in serous ovarian carcinoma: correlation with p53, MIB-1, and outcome. PubMed
CarcinomaPoly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues. PubMed
CarcinomaPoly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells. PubMed
CarcinomaPoly(ADP-ribose) polymerase activity in proliferating and quiescent murine mammary carcinoma cells. PubMed
CarcinomaPoly(ADP-ribose) polymerase gene expression status and genomic instability in human breast cancer. PubMed
CarcinomaPoly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells. PubMed
CarcinomaPoly(ADP-ribose) polymerase signaling of topoisomerase 1-dependent DNA damage in carcinoma cells. PubMed
CarcinomaPoly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells. PubMed
CarcinomaPoly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation. PubMed
CarcinomaPoly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice. PubMed
CarcinomaPoly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors. PubMed
CarcinomaPrevention of oxidant-induced cell death in Caco-2 colon carcinoma cells after inhibition of poly(ADP-ribose) polymerase and Ca2+ chelation: involvement of a common mechanism. PubMed
CarcinomaRadiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer Vaccine. PubMed
CarcinomaRas(V12) induces Survivin/AuroraB pathway conferring tumor cell apoptosis resistance. PubMed
CarcinomaReversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase. PubMed
CarcinomaSelenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation. PubMed
CarcinomaSilibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. PubMed
CarcinomaSodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK. PubMed
CarcinomaSpatiotemporal activation of caspase-dependent and -independent pathways in staurosporine-induced apoptosis of p53wt and p53mt human cervical carcinoma cells. PubMed
CarcinomaSuppression of survival in human SKBR3 breast carcinoma in response to metal-chelator complexes is preferential for copper-dithiocarbamate. PubMed
CarcinomaTankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience. PubMed
CarcinomaThe JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide. PubMed
CarcinomaThe Role of PARP Inhibitors in the Treatment of Ovarian Carcinomas. PubMed
CarcinomaTumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts. PubMed
CarcinomaTumor-suppressive effect of adenovirus-mediated inhibitor of growth 4 gene transfer in breast carcinoma cells in vitro and in vivo. PubMed
CarcinomaVEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth. PubMed
CarcinomaXanthorrhizol Induces Apoptosis Through ROS-Mediated MAPK Activation in Human Oral Squamous Cell Carcinoma Cells and Inhibits DMBA-Induced Oral Carcinogenesis in Hamsters. PubMed
Carcinoma[Expression and Implication of Base Excision Repair Genes in Human Nasopharyngeal Carcinoma and Non-tumor Nasopharyngeal Tissues.] PubMed
Carcinoma[Inhibitory effect of 5-aminoisoquinolinone on PARP activity in colon carcinoma cell line HT-29] PubMed
Carcinoma, Basal CellPARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma. PubMed
Carcinoma, DuctalNuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. PubMed
Carcinoma, Ehrlich TumorNAD[S], an NAD analogue with reduced susceptibility to phosphodiesterase. Chemical synthesis and enzymic properties. PubMed
Carcinoma, Ehrlich TumorPoly(ADP-ribose) polymerase from Ehrlich ascites tumor cells. Properties of the purified polymerase. PubMed
Carcinoma, Ehrlich TumorPurification of poly(ADP-ribose) polymerase from Ehrlich ascites tumor cells by chromatography on DNA-agarose. PubMed
Carcinoma, EndometrioidPoly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues. PubMed
Carcinoma, Hepatocellular6,(5H)-phenanthridinone protects against carbon tetrachloride-induced cytotoxicity in human HepG2 cells. PubMed
Carcinoma, HepatocellularChemopreventive action of Lygodium flexuosum extract in human hepatoma PLC/PRF/5 and Hep 3B cells. PubMed
Carcinoma, HepatocellularCloning and expression of cDNA for human poly(ADP-ribose) polymerase. PubMed
Carcinoma, HepatocellularEnhancement of cell permeabilization apoptosis-inducing activity of selenium nanoparticles by ATP surface decoration. PubMed
Carcinoma, HepatocellularExpression of poly(ADP-ribose) polymerase in human hepatocellular carcinoma and analysis of biopsy specimens obtained under sonographic guidance. PubMed
Carcinoma, HepatocellularInduction of apoptosis in normal cultured rat hepatocytes and in Hep3B, a human hepatoma cell line. PubMed
Carcinoma, HepatocellularMacrophage mediated anti-proliferation effects of Anthodia camphorata non-polysaccharide based extracts on human hepatoma cells. PubMed
Carcinoma, HepatocellularNo associations of polymorphisms in ADPRT with hepatitis B virus clearance and hepatocellular carcinoma occurrence in a Korean population. PubMed
Carcinoma, HepatocellularPJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells. PubMed
Carcinoma, HepatocellularPoly(ADP-ribose) synthase is the major endogenous nonhistone acceptor for poly(ADP-ribose) in alkylated rat hepatoma cells. PubMed
Carcinoma, HepatocellularPotentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. PubMed
Carcinoma, HepatocellularProtective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation. PubMed
Carcinoma, HepatocellularToxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. PubMed
Carcinoma, Hepatocellular[Role of proteins in Fas-mediated apoptosis in tumor cells and lymphocytes co-cultured in vitro] PubMed
Carcinoma, Intraductal, NoninfiltratingNuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. PubMed
Carcinoma, Non-Small-Cell LungFunctional Polymorphisms of Base Excision Repair Genes XRCC1 and APEX1 Predict Risk of Radiation Pneumonitis in Patients with Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy. PubMed
Carcinoma, Non-Small-Cell LungPARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer. PubMed
Carcinoma, Non-Small-Cell LungReplication-dependent ?-H2AX formation is involved in docetaxel-induced apoptosis in NSCLC A549 cells. PubMed
Carcinoma, Squamous CellBerberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. PubMed
Carcinoma, Squamous CellDiscovery and Structure-Activity Relationships of Modified Salicylanilides as Cell Permeable Inhibitors of Poly(ADP-ribose) Glycohydrolase (PARG). PubMed
Carcinoma, Squamous CellExpression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV). PubMed
Carcinoma, Squamous CellGenetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. PubMed
Carcinoma, Squamous CellOverexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer. PubMed
Carcinoma, Squamous CellParp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. PubMed
Carcinoma, Squamous CellPARP-1 Val762Ala polymorphism is associated with risk of cervical carcinoma. PubMed
Carcinoma, Squamous CellPoly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells. PubMed
Carcinoma, Squamous CellXanthorrhizol Induces Apoptosis Through ROS-Mediated MAPK Activation in Human Oral Squamous Cell Carcinoma Cells and Inhibits DMBA-Induced Oral Carcinogenesis in Hamsters. PubMed
Carcinoma, Transitional CellSilibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. PubMed
Carcinoma, Transitional CellTankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience. PubMed
CardiomegalyActivation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging. PubMed
CardiomegalyEffect of L-2286, a poly(ADP-ribose)polymerase inhibitor and enalapril on myocardial remodeling and heart failure. PubMed
CardiomegalyIncreased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure. PubMed
CardiomegalyOpposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. PubMed
CardiomegalyPARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway. PubMed
CardiomegalyPARP mediates structural alterations in diabetic cardiomyopathy. PubMed
CardiomegalyPoly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy. PubMed
CardiomegalyPossible role of poly(ADP-ribose) polymerase in pathological and physiological cardiac hypertrophy. PubMed
CardiomyopathiesCardioprotective effects of poly(ADP-ribose) polymerase inhibition. PubMed
CardiomyopathiesMyocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption. PubMed
CardiomyopathiesRegulation of kinase cascade activation and heat shock protein expression by poly(ADP-ribose) polymerase inhibition in doxorubicin-induced heart failure. PubMed
CardiomyopathiesRole of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. PubMed
CardiomyopathiesRoles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications. PubMed
CardiomyopathiesThe pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity. PubMed
Cardiomyopathy, DilatedOpposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. PubMed
Cardiovascular DiseasesIn vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters. PubMed
Cardiovascular DiseasesMitochondrial-to-nuclear translocation of apoptosis-inducing factor in cardiac myocytes during oxidant stress: potential role of poly(ADP-ribose) polymerase-1. PubMed
Cardiovascular DiseasesNovel modulators of poly(ADP-ribose) polymerase. PubMed
Cardiovascular DiseasesPARP inhibitors: New partners in the therapy of cancer and inflammatory diseases. PubMed
Cardiovascular DiseasesPCB-induced endothelial cell dysfunction: role of poly(ADP-ribose) polymerase. PubMed
Cardiovascular DiseasesPharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: future directions. PubMed
Cardiovascular DiseasesPoly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update. PubMed
Cardiovascular DiseasesPoly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. PubMed
Cardiovascular DiseasesPoly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. PubMed
Cardiovascular DiseasesPoly(ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure. PubMed
Cardiovascular DiseasesRestoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase. PubMed
Cardiovascular DiseasesRole of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. PubMed
caspase-3 deficiencyDeficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. PubMed
CataractAldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis. PubMed
CataractPoly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats. PubMed
Cell Transformation, NeoplasticAnalysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients. PubMed
Cell Transformation, NeoplasticDeficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice. PubMed
Cell Transformation, NeoplasticDNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. PubMed
Cell Transformation, NeoplasticFunctions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. PubMed
Cell Transformation, NeoplasticGenetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors. PubMed
Cell Transformation, NeoplasticGenetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. PubMed
Cell Transformation, NeoplasticImpact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs. PubMed
Cell Transformation, NeoplasticInhibition of poly(ADP-ribose) polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice. PubMed
Cell Transformation, NeoplasticInvolvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis. PubMed
Cell Transformation, NeoplasticLoss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice. PubMed
Cell Transformation, NeoplasticMolecular/Genetic therapies in ovarian cancer: future opportunities and challenges. PubMed
Cell Transformation, NeoplasticOverexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: evidence for increased tumor cell apoptosis in vivo. PubMed
Cell Transformation, NeoplasticParp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. PubMed
Cell Transformation, NeoplasticPoly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice. PubMed
Cell Transformation, NeoplasticPoly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis. PubMed
Cell Transformation, NeoplasticTannins elevate the level of poly(ADP-ribose) in HeLa cell extracts. PubMed
Cell Transformation, NeoplasticUpregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types. PubMed
Central Nervous System DiseasesMultiple roles for poly(ADP-ribose)polymerase-1 in neurological disease. PubMed
Central Nervous System DiseasesThe role of poly(ADP-ribose) polymerase-1 in CNS disease. PubMed
Cerebral HemorrhagePoly(ADP-ribose) polymerase activation and brain edema formation by hemoglobin after intracerebral hemorrhage in rats. PubMed
Cerebral InfarctionEvaluation of the poly(ADP-ribose) polymerase gene in human stroke. PubMed
Cerebral InfarctionNeuroprotective effects of KCL-440, a new poly(ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model. PubMed
CholangiocarcinomaBinding of tumour necrosis factor-alpha (TNF-alpha) to TNF-RI induces caspase(s)-dependent apoptosis in human cholangiocarcinoma cell lines. PubMed
CholeraADP-ribosyltransferase-specific modification of human neutrophil peptide-1. PubMed
CholeraCholera toxin and pertussis toxin substrates and endogenous ADP-ribosyltransferase activity in Drosophila melanogaster. PubMed
CholeraDeoxyNAD and deoxyADP-ribosylation of proteins. PubMed
CholeraHuman glycolipid transfer protein (GLTP) expression modulates cell shape. PubMed
CholeraInvolvement of Rho and p38 MAPK in endothelin-1-induced expression of PGHS-2 mRNA in osteoblast-like cells. PubMed
CholeraMono(adenosine diphosphate ribosyl) transferase in Xenopus tissues. Direct demonstration by a zymographic localization in sodium dodecyl sulfate--polyacrylamide gels. PubMed
CholeraTLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae. PubMed
CholeraVibrio fischeri genes hvnA and hvnB encode secreted NAD(+)-glycohydrolases. PubMed
ChoriocarcinomaOverexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome. PubMed
Cockayne SyndromeCooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress. PubMed
Cockayne SyndromePoly(ADP-ribosyl)ation accelerates DNA repair in a pathway dependent on Cockayne syndrome B protein. PubMed
CoinfectionActivation of caspases in pig kidney cells infected with wild-type and CrmA/SPI-2 mutants of cowpox and rabbitpox viruses. PubMed
CoinfectionC-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells. PubMed
Cold IschemiaCorrelation of morphological findings with functional reserve in the aging donor: role of the poly (ADP-ribose) polymerase. PubMed
Cold IschemiaPoly(ADP-ribose) polymerase expression in kidney transplantation: from alfa (alpha) to Omega (Omega). PubMed
Cold IschemiaPoly[ADP-ribose] polymerase-1 expression is related to cold ischemia, acute tubular necrosis, and delayed renal function in kidney transplantation. PubMed
Cold IschemiaRole of poly (ADP-ribose) polymerase in kidney transplant and its relationship with delayed renal function: multivariate analysis. PubMed
Cold IschemiaRole of poly-(ADP-ribose) polymerase in transplant acute tubular necrosis and its relationship with delayed renal function. PubMed
Colitis5-Aminoisoquinolinone reduces colon injury by experimental colitis. PubMed
ColitisActivator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis. PubMed
ColitisInhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis. PubMed
ColitisInhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis. PubMed
ColitisPARP inhibition reduces acute colonic inflammation in rats. PubMed
ColitisPoly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. PubMed
ColitisPoly(ADP-ribose) polymerase inhibitors. PubMed
ColitisPoly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. PubMed
ColitisPoly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation. PubMed
ColitisPoly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications. PubMed
ColitisStructure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. PubMed
ColitisThe Peri-appendiceal Red Patch in Ulcerative Colitis: Review of the University of Chicago Experience. PubMed
ColitisTreatment with PARP-1 inhibitors, GPI 15427 or GPI 16539, ameliorates intestinal damage in rat models of colitis and shock. PubMed
ColitisUpregulation of Salmonella-induced IL-6 production in Caco-2 cells by PJ-34, PARP-1 inhibitor: involvement of PI3K, p38 MAPK, ERK, JNK, and NF-kappaB. PubMed
Colitis, UlcerativePARP inhibition reduces acute colonic inflammation in rats. PubMed
Colonic NeoplasmsAbsence of stimulation of poly(ADP-ribose) polymerase activity in patients predisposed to colon cancer. PubMed
Colonic NeoplasmsAcriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis. PubMed
Colonic NeoplasmsBufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. PubMed
Colonic NeoplasmsCheckpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. PubMed
Colonic NeoplasmsCommon fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1. PubMed
Colonic NeoplasmsCytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis. PubMed
Colonic NeoplasmsDetection of poly(ADP-ribose) polymerase cleavage in response to treatment with topoisomerase I inhibitors: a potential surrogate end point to assess treatment effectiveness. PubMed
Colonic NeoplasmsDimeric 3,5-bis(benzylidene)-4-piperidones: A novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties. PubMed
Colonic NeoplasmsDNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. PubMed
Colonic NeoplasmsInduction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway. PubMed
Colonic NeoplasmsInhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma. PubMed
Colonic NeoplasmsMechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization. PubMed
Colonic NeoplasmsMethylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad. PubMed
Colonic NeoplasmsNovel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. PubMed
Colonic NeoplasmsPatulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation. PubMed
Colonic NeoplasmsPhotodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice. PubMed
Colonic NeoplasmsPolyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study. PubMed
Colonic NeoplasmsSclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice. PubMed
Colonic NeoplasmsThe pro-apoptotic effect of quercetin in cancer cell lines requires ER?-dependent signals. PubMed
Colonic NeoplasmsTRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death. PubMed
Colonic NeoplasmsTumor necrosis factor-alpha induces apoptosis associated with poly(ADP-ribose) polymerase cleavage in HT-29 colon cancer cells. PubMed
Colonic NeoplasmsTwo new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PubMed
Colorectal NeoplasmsA novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. PubMed
Colorectal NeoplasmsChromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. PubMed
Colorectal NeoplasmsColorectal cancers differ in respect of PARP-1 protein expression. PubMed
Colorectal NeoplasmsDNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. PubMed
Colorectal NeoplasmsEffect of acidic environment and p53 on apoptosis induction by hyperthermia. PubMed
Colorectal NeoplasmsInhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma. PubMed
Colorectal NeoplasmsMRE11 Deficiency Increases Sensitivity to Poly(ADP-ribose) Polymerase Inhibition in Microsatellite Unstable Colorectal Cancers. PubMed
Colorectal NeoplasmsMSH3 Mediates Sensitization of Colorectal Cancer Cells to Cisplatin, Oxaliplatin, and a Poly(ADP-ribose) Polymerase Inhibitor. PubMed
Colorectal NeoplasmsNew structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells. PubMed
Colorectal NeoplasmsOverexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis. PubMed
Colorectal NeoplasmsPoly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells. PubMed
Colorectal NeoplasmsPoly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. PubMed
Colorectal NeoplasmsRadiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate. PubMed
Colorectal NeoplasmsTemozolomide: Mechanisms of Action, Repair and Resistance. PubMed
Colorectal Neoplasms[Inhibitory effect of 5-aminoisoquinolinone on PARP activity in colon carcinoma cell line HT-29] PubMed
Colorectal Neoplasms, Hereditary NonpolyposisTemozolomide: Mechanisms of Action, Repair and Resistance. PubMed
CowpoxActivation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. PubMed
CowpoxIL-3 withdrawal activates a CrmA-insensitive poly(ADP-ribose) polymerase cleavage enzyme in factor-dependent myeloid progenitor cells. PubMed
Craniocerebral TraumaA novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury: An immunohistochemical and behavioral study. PubMed
Craniocerebral TraumaDevelopment of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors. PubMed
Craniocerebral TraumaPoly(adenosine diphosphate-ribose) polymerase expression in human traumatic brain injury. PubMed
Crohn DiseaseDistinct production of autoantibodies to nuclear components in ulcerative colitis and in Crohn's disease. PubMed
CryptorchidismHeat stress reduces poly(ADPR)polymerase expression in rat testis. PubMed
Cystadenoma, SerousPoly(adenosine diphosphate-ribose) polymerase expression in serous ovarian carcinoma: correlation with p53, MIB-1, and outcome. PubMed
Cystic FibrosisChildren with cystic fibrosis produce an immune response against exoenzyme S, a type III cytotoxin of Pseudomonas aeruginosa. PubMed
Cystic FibrosisDistinct fates of monocytes and T cells directly activated by Pseudomonas aeruginosa exoenzyme S. PubMed
Cystic FibrosisPseudomonas aeruginosa exoenzyme S induces transcriptional expression of proinflammatory cytokines and chemokines. PubMed
Cystic FibrosisRole of exoenzyme S in chronic Pseudomonas aeruginosa lung infections. PubMed
CystitisPathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. PubMed
CystitisProtein nitration, PARP activation and NAD+ depletion may play a critical role in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis in the rat. PubMed
Demyelinating DiseasesActivation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage. PubMed
Demyelinating DiseasesIL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis. PubMed
Demyelinating DiseasesInhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death. PubMed
Demyelinating DiseasesPARP-1 deletion promotes subventricular zone neural stem cells toward a glial fate. PubMed
Demyelinating DiseasesPARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity. PubMed
DermatitisStructure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. PubMed
Dermatitis, Allergic ContactNitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. PubMed
Dermatitis, ContactGenetic ablation of PARP-1 protects against oxazolone-induced contact hypersensitivity by modulating oxidative stress. PubMed
Dermatitis, ContactNitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. PubMed
Dermatitis, ContactPeroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity. PubMed
Dermatitis, ContactPoly(ADP-ribose) polymerase mediates inflammation in a mouse model of contact hypersensitivity. PubMed
Diabetes ComplicationsAldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications. PubMed
Diabetes ComplicationsDiabetes, microvascular complications, and cardiovascular complications: what is it about glucose? PubMed
Diabetes ComplicationsDiabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation. PubMed
Diabetes ComplicationsDoes diabetes mellitus target motor neurons? PubMed
Diabetes ComplicationsIncreased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications. PubMed
Diabetes ComplicationsOxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications. PubMed
Diabetes ComplicationsOxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase (PARP) Activation in Experimental Diabetic Neuropathy: The Relation Is Revisited. PubMed
Diabetes ComplicationsPARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy. PubMed
Diabetes ComplicationsPARP mediates structural alterations in diabetic cardiomyopathy. PubMed
Diabetes ComplicationsPoly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy. PubMed
Diabetes ComplicationsPoly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. PubMed
Diabetes ComplicationsPoly(ADP-ribose) polymerase is involved in the development of diabetic cystopathy via regulation of nuclear factor kappa B. PubMed
Diabetes ComplicationsPoly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice. PubMed
Diabetes ComplicationsRole of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies. PubMed
Diabetes ComplicationsRole of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme. PubMed
Diabetes ComplicationsRoles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications. PubMed
Diabetes ComplicationsThe pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity. PubMed
Diabetes MellitusAdenosine thiamine triphosphate (AThTP) inhibits poly(ADP-ribose) polymerase-1 (PARP-1) activity. PubMed
Diabetes MellitusDiabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase. PubMed
Diabetes MellitusNitrative stress and poly(ADP-ribose) polymerase activation in healthy and gestational diabetic pregnancies. PubMed
Diabetes MellitusPARP as a Drug Target for the Therapy of Diabetic Cardiovascular Dysfunction. PubMed
Diabetes MellitusPoly(ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus. PubMed
Diabetes MellitusPoly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update. PubMed
Diabetes MellitusPoly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor. PubMed
Diabetes MellitusPoly(ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury. PubMed
Diabetes MellitusQuantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies. PubMed
Diabetes MellitusRapid 'glycaemic swings' induce nitrosative stress, activate poly(ADP-ribose) polymerase and impair endothelial function in a rat model of diabetes mellitus. PubMed
Diabetes MellitusRoles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications. PubMed
Diabetes MellitusTempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus. PubMed
Diabetes Mellitus, ExperimentalTempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus. PubMed
Diabetes Mellitus, Type 1Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase. PubMed
Diabetes Mellitus, Type 2Poly(ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus. PubMed
Diabetic CardiomyopathiesBeneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure. PubMed
Diabetic CardiomyopathiesMetallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme. PubMed
Diabetic CardiomyopathiesPARP mediates structural alterations in diabetic cardiomyopathy. PubMed
Diabetic CardiomyopathiesXanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy. PubMed
Diabetic NephropathiesGallotannin ameliorates the development of streptozotocin-induced diabetic nephropathy by preventing the activation of PARP. PubMed
Diabetic NephropathiesPoly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model. PubMed
Diabetic NephropathiesPoly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. PubMed
Diabetic NephropathiesPoly(ADP-ribose) polymerase-1 (PARP-1) gene deficiency alleviates diabetic kidney disease. PubMed
Diabetic NephropathiesRole for poly(ADP-ribose) polymerase activation in diabetic nephropathy, neuropathy and retinopathy. PubMed
Diabetic NephropathiesRole of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies. PubMed
Diabetic NeuropathiesBone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion. PubMed
Diabetic NeuropathiesConcurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy. PubMed
Diabetic NeuropathiesEffects of poly(ADP-ribose) polymerase inhibition on dysfunction of non-adrenergic non-cholinergic neurotransmission in gastric fundus in diabetic rats. PubMed
Diabetic NeuropathiesEvaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy. PubMed
Diabetic NeuropathiesFunctional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy. PubMed
Diabetic NeuropathiesLeu54Phe and Val762Ala polymorphisms in the poly(ADP-ribose)polymerase-1 gene are associated with diabetic polyneuropathy in Russian type 1 diabetic patients. PubMed
Diabetic NeuropathiesLow-dose poly(ADP-ribose) polymerase inhibitor-containing combination therapies reverse early peripheral diabetic neuropathy. PubMed
Diabetic NeuropathiesNew Therapeutic and Biomarker Discovery for Peripheral Diabetic Neuropathy: PARP Inhibitor, Nitrotyrosine, and Tumor Necrosis Factor-{alpha} PubMed
Diabetic NeuropathiesOxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase (PARP) Activation in Experimental Diabetic Neuropathy: The Relation Is Revisited. PubMed
Diabetic NeuropathiesPARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy. PubMed
Diabetic NeuropathiesPoly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy. PubMed
Diabetic NeuropathiesPoly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: a commentary on 'PARP Inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy'. PubMed
Diabetic NeuropathiesProtective effects of 4-amino1,8-napthalimide, a poly (ADP-ribose) polymerase inhibitor in experimental diabetic neuropathy. PubMed
Diabetic NeuropathiesRole of poly(ADP-ribose) polymerase activation in diabetic neuropathy. PubMed
Diabetic NeuropathiesTreatment with Actovegin® Improves Sensory Nerve Function and Pathology in Streptozotocin-Diabetic Rats via Mechanisms Involving Inhibition of PARP Activation. PubMed
Diabetic RetinopathyAldose Reductase / Polyol Inhibitors For Diabetic Retinopathy. PubMed
Diabetic RetinopathyPARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes. PubMed
Diabetic RetinopathyPoly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression. PubMed
Diabetic RetinopathyPoly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB. PubMed
Diabetic RetinopathyRole of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy. PubMed
DiphtheriaA chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly. PubMed
DiphtheriaBacterial toxins inhibiting or activating small GTP-binding proteins. PubMed
DiphtheriaProduction of exoenzyme S by clinical isolates of Pseudomonas aeruginosa. PubMed
DiphtheriaPseudomonas aeruginosa exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A. PubMed
DiphtheriaRegulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function. PubMed
DiphtheriaStructure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa. PubMed
DiphtheriaUse of biotinylated NAD to label and purify ADP-ribosylated proteins. PubMed
Down SyndromeThe role of poly(ADP-ribose)polymerase in the induction of sister chromatid exchanges and micronuclei by mitomycin C in Down's syndrome cells as compared to euploid cells. PubMed
DyslipidemiasProtective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE mice: effects on eNOS and oxidative stress. PubMed
EhrlichiosisSpecific processing of poly(ADP-ribose) polymerase, accompanied by activation of caspase-3 and elevation/reduction of ceramide/hydrogen peroxide levels, during induction of apoptosis in host HL-60 cells infected by the human granulocytic ehrlichiosis (HGE) agent. PubMed
EncephalitisDamage and repair of DNA in HIV encephalitis. PubMed
EncephalitisEstrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling. PubMed
EncephalitisThe role of poly(ADP-ribose) polymerase-1 in CNS disease. PubMed
EncephalomyelitisInhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. PubMed
EncephalomyelitisPARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. PubMed
EncephalomyelitisPARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity. PubMed
Encephalomyelitis, Autoimmune, ExperimentalInhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. PubMed
Encephalomyelitis, Autoimmune, ExperimentalPARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. PubMed
Encephalomyelitis, Autoimmune, ExperimentalPARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity. PubMed
Encephalomyelitis, Autoimmune, ExperimentalPoly(ADP-ribose) polymerase inhibitors. PubMed
Encephalomyelitis, Autoimmune, ExperimentalPoly(ADP-ribose) polymerase-1 activation in a primate model of multiple sclerosis. PubMed
Encephalomyelitis, Autoimmune, ExperimentalThe therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation. PubMed
Endometrial HyperplasiaPoly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors. PubMed
Endometrial NeoplasmsHistone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells. PubMed
Endometrial NeoplasmsPARP inhibitors in BRCA gene-mutated ovarian cancer and beyond. PubMed
Endometrial NeoplasmsPoly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues. PubMed
Endometrial NeoplasmsPoly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors. PubMed
Endometrial NeoplasmsPTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors. PubMed
EndotoxemiaNicotinamide increases systemic vascular resistance in ovine endotoxemia. PubMed
EndotoxemiaRole of lipopolysaccharide and cecal ligation and puncture on blood coagulation and inflammation in sensitive and resistant mice models. PubMed
EndotoxemiaRole of PARP on iNOS pathway during endotoxin-induced acute lung injury. PubMed
EndotoxemiaSystemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia. PubMed
Enterocolitis, NecrotizingPoly(ADP-Ribose) Polymerase-1: A Novel Therapeutic Target in Necrotizing Enterocolitis. PubMed
EosinophiliaPARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model. PubMed
EosinophiliaPost-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation. PubMed
EosinophiliaReciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia. PubMed
EpendymomaPARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. PubMed
Erectile DysfunctionPoly(Adenosine diphosphate-ribose) polymerase inhibition preserves erectile function in rats after cavernous nerve injury. PubMed
Erectile DysfunctionPoly(ADP-ribose) polymerase inhibition reverses nitrergic neurovascular dysfunctions in penile erectile tissue from streptozotocin-diabetic mice. PubMed
ErythemaNitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. PubMed
ExanthemaAssociation of apoptosis-related microsatellite polymorphisms on chromosome 1q in Taiwanese systemic lupus erythematosus patients. PubMed
Fanconi AnemiaNo abnormalities in the NAD+ ADP-ribosyltransferase (polymerizing) gene of transformed cells from a Fanconi's anemia patient. PubMed
Fanconi AnemiaRare mutations in XRCC2 increase the risk of breast cancer. PubMed
Fanconi AnemiaThe cellular control enzyme polyADP ribosyl transferase is eliminated in cultured Fanconi anemia fibroblasts at confluency. PubMed
Fanconi AnemiaThe Fanconi anemia cell line HSC536N is not sensitive to interferon-gamma and does not cleave PARP in response to FAS-mediated cell killing. PubMed
Fatty LiverOval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. PubMed
Fetal Growth RetardationAdministration of the Parp Inhibitor Pj34 Ameliorates the Impaired Vascular Function Associated With Enos-/- Mice. PubMed
FibrosarcomaResponse of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation. PubMed
FibrosarcomaRole of JNK-1 regulation in the protection of contact-inhibited fibroblasts from oxidative stress. PubMed
FurunculosisCharacterization of an ADP-ribosyltransferase toxin (AexT) from Aeromonas salmonicida subsp. salmonicida. PubMed
GlioblastomaA novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. PubMed
GlioblastomaChemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. PubMed
GlioblastomaComparative status of activated ERK1/2 and PARP cleavage in human gliomas. PubMed
GlioblastomaDiscovery of a perinecrotic 60 kDa MDM2 isoform within glioma spheroids and glioblastoma biopsy material. PubMed
GlioblastomaEffective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines. PubMed
GlioblastomaExpression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model. PubMed
GlioblastomaGlioblastoma multiforme: overview of current treatment and future perspectives. PubMed
GlioblastomaImpact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme. PubMed
GlioblastomaIntratumor administration of interleukin 13 receptor-targeted cytotoxin induces apoptotic cell death in human malignant glioma tumor xenografts. PubMed
GlioblastomaOvercoming Resistance of Glioblastoma to Conventional Cytotoxic Therapies by the Addition of PARP Inhibitors. PubMed
GlioblastomaPARP-1 protein expression in glioblastoma multiforme. PubMed
GlioblastomaPoly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells. PubMed
GlioblastomaPoly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation. PubMed
GlioblastomaPoly(ADPR)polymerase-1 signalling of the DNA damage induced by DNA topoisomerase I poison in D54(p53wt) and U251(p53mut) glioblastoma cell lines. PubMed
GlioblastomaPTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors. PubMed
GlioblastomaSynthetic chenodeoxycholic acid derivatives inhibit glioblastoma multiform tumor growth in vitro and in vivo. PubMed
GlioblastomaSystemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. PubMed
GlioblastomaTemozolomide: Mechanisms of Action, Repair and Resistance. PubMed
GlioblastomaUrokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells. PubMed
GliomaAG490 influences UCN-01-induced cytotoxicity in Glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation. PubMed
GliomaAntitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor. PubMed
GliomaAssociation between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis. PubMed
GliomaCombination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme. PubMed
GliomaComparative status of activated ERK1/2 and PARP cleavage in human gliomas. PubMed
GliomaDifferential PARP cleavage: an indication for existence of multiple forms of cell death in human gliomas. PubMed
GliomaEnhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90. PubMed
GliomaExpression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model. PubMed
GliomaH2O2-induced cell death in human glioma cells: role of lipid peroxidation and PARP activation. PubMed
GliomaIdentification of a 116 kDa protein able to bind 1,3-bis(2-chloroethyl)-1-nitrosourea-damaged DNA as poly(ADP-ribose) polymerase. PubMed
GliomaInduction of apoptosis in glioma cells requires cell-to-cell contact with human umbilical cord blood stem cells. PubMed
GliomaLarge-conductance K+ channel openers induce death of human glioma cells. PubMed
GliomamTOR, S6 and AKT expression in relation to proliferation and apoptosis/autophagy in glioma. PubMed
GliomaN-methylpurine DNA glycosylase and DNA polymerase {beta} modulate BER inhibitor potentiation of glioma cells to temozolomide. PubMed
GliomaNADPH treatment decreases C6 glioma cell survival by increasing oxidative stress. PubMed
GliomaOncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway. PubMed
GliomaOxidative stress and PARP activation mediate the NADH-induced decrease in glioma cell survival. PubMed
GliomaOxidative stress induces apoptosis in C6 glioma cells: involvement of mitogen-activated protein kinases and nuclear factor kappa B. PubMed
GliomaPARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. PubMed
GliomaPARP-1, PARP-2, and the cellular response to low doses of ionizing radiation. PubMed
GliomaPediatric high-grade glioma: identification of poly(ADP-ribose) polymerase as a potential therapeutic target. PubMed
GliomaPoly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells. PubMed
GliomaPoly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft. PubMed
GliomaPoly(ADP-ribose) polymerase-independent potentiation of nitrosourea cytotoxicity by 3-aminobenzamide in human malignant glioma cells. PubMed
GliomaPre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers. PubMed
GliomaProtein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures. PubMed
GliomaReplication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: mechanisms and therapeutic potential. PubMed
GliomaRho/ROCK pathway as a target of tumor therapy. PubMed
GliomaSystemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. PubMed
GliomaWhole-body hyperthermia and ADPRT inhibition in experimental treatment of brain tumors. PubMed
GliosarcomaCellular regulation of poly(ADP) ribosylation of proteins. I. Comparison of hepatocytes, cultured cells and liver nuclei and the influence of varying concentrations of NAD. PubMed
GlomerulonephritisPoly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation. PubMed
Glucose IntolerancePoly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. PubMed
Head and Neck NeoplasmsHead and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427. PubMed
Head and Neck NeoplasmsSynergistic inhibition of head and neck tumor growth by green tea (-)-epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor. PubMed
Head and Neck NeoplasmsThe poly(ADP-Ribose) polymerase inhibitor ABT-888 reduces radiation-induced nuclear EGFR and augments head and neck tumor response to radiotherapy. PubMed
Heart ArrestInhibition of poly(adp-ribose) polymerase reduces cardiomyocytic apoptosis after global cardiac arrest under cardiopulmonary bypass. PubMed
Heart ArrestINO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation. PubMed
Heart ArrestMesenteric injury after cardiopulmonary bypass: role of poly(adenosine 5'-diphosphate-ribose) polymerase. PubMed
Heart ArrestNeuronal accumulation of poly(ADP-ribose) after brain ischaemia. PubMed
Heart ArrestPoly(ADP-ribose) polymerase inhibitor PJ-34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest. PubMed
Heart ArrestRole of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass. PubMed
Heart DiseasesIn vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters. PubMed
Heart Diseases[Research progress of poly (ADP-ribose) polymerase-1 in cardiac diseases.] PubMed
Heart FailureActivation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure. PubMed
Heart FailureActivation of the poly(ADP-ribose) polymerase pathway in human heart failure. PubMed
Heart FailureAdditional use of immunostaining for active caspase 3 and cleaved actin and PARP fragments to detect apoptosis in patients with chronic heart failure. PubMed
Heart FailureBeneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure. PubMed
Heart FailureCardioprotective effects of poly(ADP-ribose) polymerase inhibition. PubMed
Heart FailureEffect of L-2286, a poly(ADP-ribose)polymerase inhibitor and enalapril on myocardial remodeling and heart failure. PubMed
Heart FailureIncreased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure. PubMed
Heart FailureMyocardial cell death and regeneration during progression of cardiac hypertrophy to heart failure. PubMed
Heart FailureNitrosative stress and pharmacological modulation of heart failure. PubMed
Heart FailurePARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats. PubMed
Heart FailurePARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway. PubMed
Heart FailurePharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. PubMed
Heart FailurePoly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update. PubMed
Heart FailurePoly(ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure. PubMed
Heart FailurePoly(ADP-ribose) polymerase regulates myocardial calcium handling in doxorubicin-induced heart failure. PubMed
Heart FailurePoly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy. PubMed
Heart FailurePoly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. PubMed
Heart FailureRegulation of kinase cascade activation and heat shock protein expression by poly(ADP-ribose) polymerase inhibition in doxorubicin-induced heart failure. PubMed
Heart FailureRole of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. PubMed
Heart FailureRole of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. PubMed
Hematologic NeoplasmsCombined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site. PubMed
Hematologic NeoplasmsThe Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy; Use as a Single Agent in Susceptible Patients; Techniques Used to Identify Susceptible Patients. PubMed
HepatitisInfluence of diet free of NAD-precursors on acetaminophen hepatotoxicity in mice. PubMed
HepatitisTRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. PubMed
Hepatitis BNo associations of polymorphisms in ADPRT with hepatitis B virus clearance and hepatocellular carcinoma occurrence in a Korean population. PubMed
Herpes SimplexHerpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase. PubMed
Herpes SimplexHerpes simplex virus requires poly(ADP-ribose) polymerase activity for efficient replication and induces extracellular signal-related kinase-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1. PubMed
Herpes SimplexInhibition of poly(ADP-ribose)polymerase stimulates extrachromosomal homologous recombination in mouse Ltk-fibroblasts. PubMed
Histiocytic Sarcoma[Role of proteins in Fas-mediated apoptosis in tumor cells and lymphocytes co-cultured in vitro] PubMed
HIV InfectionsA major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis. PubMed
HIV InfectionsMinireview, The oxidative stress-induced niacin sink (OSINS) model for HIV pathogenesis. PubMed
HyperalgesiaConcurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy. PubMed
HyperalgesiaPARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy. PubMed
HyperalgesiaPARP inhibitors attenuate chemotherapy-induced painful neuropathy. PubMed
HyperalgesiaPoly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice. PubMed
HyperalgesiaRhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice. PubMed
HyperglycemiaAntioxidant therapy in diabetic complications: what is new? PubMed
HyperglycemiaComparative study of peripheral neuropathy and nerve regeneration in NOD and ICR diabetic mice. PubMed
HyperglycemiaContribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid. PubMed
HyperglycemiaDiabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. PubMed
HyperglycemiaMolecular targets of diabetic vascular complications and potential new drugs. PubMed
HyperglycemiaPoly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB. PubMed
HyperglycemiaPoly(ADP-ribose)polymerase activity is reduced in circulating mononuclear cells from type 2 diabetic patients. PubMed
HyperglycemiaPoly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice. PubMed
HyperglycemiaSirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin. PubMed
HyperglycemiaThe role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes. PubMed
HyperglycemiaTreatment with insulin inhibits poly(ADP-ribose)polymerase activation in a rat model of endotoxemia. PubMed
HyperhomocysteinemiaMelatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels. PubMed
HyperhomocysteinemiaPoly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by hyperhomocysteinemia in rats. PubMed
HyperlipidemiasPoly (ADP-Ribose) Polymerase Inhibition Attenuates Atherosclerotic Plaque Development in ApoE-/- Mice with Hyperhomocysteinemia. PubMed
Hypersensitivity53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. PubMed
HypersensitivityBase excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1. PubMed
HypersensitivityDecreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase beta-deficient mice. PubMed
HypersensitivityHypersensitivity to clinically useful alkylating agents and radiation in poly(ADP-ribose) polymerase-deficient cell lines. PubMed
HypersensitivityIncreased PARP-1 Association with DNA in Alkylation Damaged, PARP-Inhibited Mouse Fibroblasts. PubMed
HypersensitivityPoly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. PubMed
HypersensitivityPoly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. PubMed
HypersensitivityPoly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications. PubMed
HypersensitivitySensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. PubMed
HypersensitivitySynaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2. PubMed
HypersensitivityTargeting poly(ADP-ribose) polymerase activity for cancer therapy. PubMed
HypersensitivityThe USP1/UAF1 complex promotes double-strand break repair through homologous recombination. PubMed
HypertensionActivation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging. PubMed
HypertensionAngiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation. PubMed
HypertensionContribution of poly(ADP-ribose) polymerase to endothelial dysfunction and hypertension in a rat model of pre-eclampsia. PubMed
HypertensionInhibition of PARP prevents angiotensin II-induced aortic fibrosis in rats. PubMed
HypertensioniNOS induction and PARP-1 activation in human atherosclerotic lesions: an immunohistochemical and ultrastructural approach. PubMed
HypertensionPCB-induced endothelial cell dysfunction: role of poly(ADP-ribose) polymerase. PubMed
HypertensionRole of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. PubMed
HypoglycemiaHypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia. PubMed
HypoglycemiaPostnatal Age Influences Hypoglycemia-induced Poly(ADP-ribose) Polymerase-1 Activation in the Brain Regions of Rats. PubMed
HypoglycemiaPrevention of acute/severe hypoglycemia-induced neuron death by lactate administration. PubMed
HypoglycemiaPyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment. PubMed
HypoglycemiaSignaling pathways involved in thrombin-induced cell protection. PubMed
HypoglycemiaZinc release contributes to hypoglycemia-induced neuronal death. PubMed
HypotensionActivation and modulation of cardiac poly-adenosine diphosphate ribose polymerase activity in a rat model of brain death. PubMed
HypotensionThe neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia. PubMed
Immune System DiseasesA key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation. PubMed
Infarction, Middle Cerebral ArteryEnhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain. PubMed
Infarction, Middle Cerebral ArteryInfluence of electroacupuncture on the mRNA of heat shock protein 70 and 90 in brain after cerebral ischemia/reperfusion of rats. PubMed
Infarction, Middle Cerebral ArteryLong-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment. PubMed
Infarction, Middle Cerebral ArteryMP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model. PubMed
Infarction, Middle Cerebral ArteryNeuroprotective effect of 4-amino-1,8-napthalimide, a poly(ADP ribose) polymerase inhibitor in middle cerebral artery occlusion-induced focal cerebral ischemia in rat. PubMed
Infarction, Middle Cerebral ArteryNeuroprotective effects of KCL-440, a new poly(ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model. PubMed
Infarction, Middle Cerebral ArteryNeuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. PubMed
Infarction, Middle Cerebral ArteryPoly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage. PubMed
Infarction, Middle Cerebral ArteryPoly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. PubMed
Infarction, Middle Cerebral ArteryPoly(ADP-ribose) polymerase inhibition by cilostazol is implicated in the neuroprotective effect against focal cerebral ischemic infarct in rat. PubMed
Infarction, Middle Cerebral ArteryTumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death. PubMed
InfectionActivation of caspases in pig kidney cells infected with wild-type and CrmA/SPI-2 mutants of cowpox and rabbitpox viruses. PubMed
InfectionActivation of cell signaling pathways is dependant on the biotype of bovine viral diarrhea viruses type 2. PubMed
InfectionActivation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori. PubMed
InfectionAdenovirus-Mediated Gene Transfer of FKHRL1 Triple Mutant Efficiently Induces Apoptosis in Melanoma Cells. PubMed
InfectionADP-ribosylation by exoenzyme T of Pseudomonas aeruginosa induces an irreversible effect on the host cell cytoskeleton in vivo. PubMed
InfectionApoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. PubMed
InfectionApoptosis of human retina and retinal pigment cells induced by human cytomegalovirus infection. PubMed
InfectionApoptosis-inducing factor contributes to epithelial cell apoptosis induced by enteropathogenic Escherichia coli. PubMed
InfectionBax is activated during rotavirus-induced apoptosis through the mitochondrial pathway. PubMed
InfectionBlockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of beta1-integrin, ERK, and NF-kappaB. PubMed
InfectionCaspase activation and specific cleavage of substrates after coxsackievirus B3-induced cytopathic effect in HeLa cells. PubMed
InfectionCaspase-mediated cleavage of adenovirus early region 1A proteins. PubMed
InfectionCaspase-mediated cleavage of the feline calicivirus capsid protein. PubMed
InfectionChlamydia pneumoniae alters mildly oxidized low-density lipoprotein-induced cell death in human endothelial cells, leading to necrosis rather than apoptosis. PubMed
InfectionCombined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells. PubMed
InfectionContribution of exoenzyme S to the virulence of Pseudomonas aeruginosa. PubMed
InfectionCoxiella burnetii induces apoptosis during early stage infection via a caspase-independent pathway in human monocytic THP-1 cells. PubMed
InfectionDNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration. PubMed
InfectionEfficient retroviral infection of mammalian cells is blocked by inhibition of poly(ADP-ribose) polymerase activity. PubMed
InfectionExamining the Role of Actin-Plasma Membrane Association in Pseudomonas aeruginosa Infection and Type III Secretion Translocation in Migratory T24 Epithelial Cells. PubMed
InfectionExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury. PubMed
InfectionExpression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV). PubMed
InfectionExpression of cytotoxicity-associated genes in Marek's disease virus-infected chickens. PubMed
InfectionFlavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection. PubMed
InfectionFunctional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection. PubMed
InfectionGenetic and pharmacological inhibition of poly(ADP-ribose) polymerase-1 interferes in the chlamydial life cycle. PubMed
InfectionGenetic approaches to study Pseudomonas aeruginosa protein antigens. PubMed
InfectionHerpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase. PubMed
InfectionHippocampal poly(ADP-Ribose) polymerase 1 and caspase 3 activation in neonatal bornavirus infection. PubMed
InfectionHuman cytomegalovirus UL38 protein blocks apoptosis. PubMed
InfectionIncrease in de novo HBV DNA integrations in response to oxidative DNA damage or inhibition of poly(ADP-ribosyl)ation. PubMed
InfectionInduction of apoptosis and cleavage of poly(ADP-ribose) polymerase by cytopathic bovine viral diarrhea virus infection. PubMed
InfectionInhibition of host cell apoptosis by Toxoplasma gondii is accompanied by reduced activation of the caspase cascade and alterations of poly(ADP-ribose) polymerase expression. PubMed
InfectionInhibition of ICE-like proteases inhibits apoptosis and increases virus production during adenovirus infection. PubMed
InfectionInhibition of Poly(ADP-ribose)polymerase impairs Epstein Barr Virus lytic cycle progression. PubMed
InfectionInsulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer. PubMed
InfectionInteraction of Sindbis virus non-structural protein 3 with poly(ADP-ribose) polymerase 1 in neuronal cells. PubMed
InfectionIs rheumatoid arthritis a consequence of natural selection for enhanced tuberculosis resistance? PubMed
InfectionIsolation and characterization of transposon-induced mutants of Pseudomonas aeruginosa deficient in production of exoenzyme S. PubMed
InfectionMetallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply. PubMed
InfectionMMP-2 siRNA induced Fas/CD95-mediated extrinsic II apoptotic pathway in the A549 lung adenocarcinoma cell line. PubMed
InfectionModulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress. PubMed
InfectionNitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. PubMed
InfectionNo associations of polymorphisms in ADPRT with hepatitis B virus clearance and hepatocellular carcinoma occurrence in a Korean population. PubMed
InfectionNSm protein of Rift Valley fever virus suppresses virus-induced apoptosis. PubMed
InfectionNuclear Translocation of NF-{kappa}B Precedes Apoptotic Poly(ADP-ribose) Polymerase Cleavage during Productive HSV-1 Replication in Corneal Epithelial Cells. PubMed
InfectionNuMA and nuclear lamins are cleaved during viral infection--inhibition of caspase activity prevents cleavage and rescues HeLa cells from measles virus-induced but not from rhinovirus 1B-induced cell death. PubMed
InfectionPARP-1 Val762Ala polymorphism, CagA(+) H. pylori infection and risk for gastric cancer in Han Chinese population. PubMed
InfectionPhenotypic comparison of Pseudomonas aeruginosa strains isolated from a variety of clinical sites. PubMed
InfectionPoly(ADP-ribose) polymerase 1 is not strictly required for infection of murine cells by retroviruses. PubMed
InfectionPoly(ADP-ribose) polymerase activity in various U937 cell subclones with different susceptibility to HIV-1 infection: its dramatic decrease following persistent virus infection. PubMed
InfectionPoly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. PubMed
InfectionPoly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration. PubMed
InfectionPoly(ADP-ribose)polymerase activity is reduced in circulating mononuclear cells from type 2 diabetic patients. PubMed
InfectionPoly(ADP-ribose)polymerase inhibition - where now? PubMed
InfectionPotent antitumor efficacy of XAF1 delivered by conditionally replicative adenovirus vector via caspase-independent apoptosis. PubMed
InfectionProduction of exoenzyme S during Pseudomonas aeruginosa infections of burned mice. PubMed
InfectionProduction of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections. PubMed
InfectionPseudomonas aeruginosa exoenzyme S stimulates murine lymphocyte proliferation in vitro. PubMed
InfectionPseudomonas aeruginosa strains obtained from patients with tracheal, urinary tract and wound infection: variations in virulence factors and virulence genes. PubMed
InfectionRac1, RhoA, and Cdc42 participate in HeLa cell invasion by group B streptococcus. PubMed
InfectionRapid activation of poly(ADP-ribose) polymerase contributes to Sindbis virus and staurosporine-induced apoptotic cell death. PubMed
InfectionRescue of Helicobacter pylori-induced cytotoxicity by red ginseng. PubMed
InfectionRespiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway. PubMed
InfectionRole of exoenzyme S in chronic Pseudomonas aeruginosa lung infections. PubMed
InfectionRole of Pseudomonas aeruginosa extracellular enzymes in lung disease. PubMed
InfectionSevere acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity. PubMed
InfectionSimian virus 40 infection triggers a balanced network that includes apoptotic, survival, and stress pathways. PubMed
InfectionStabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. PubMed
InfectionTemporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells. PubMed
InfectionThe ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities. PubMed
InfectionThe role of exoenzyme S in infections with Pseudomonas aeruginosa. PubMed
InfectionTransient inhibition of poly(ADP-ribose) polymerase expression and activity by Toxoplasma gondii is dispensable for parasite-mediated blockade of host cell apoptosis and intracellular parasite replication. PubMed
InfectionU20 Is Responsible for Human Herpesvirus 6B Inhibition of TNF Receptor-Dependent Signaling and Apoptosis. PubMed
InfectionUse of transposon mutants to assess the role of exoenzyme S in chronic pulmonary disease due to Pseudomonas aeruginosa. PubMed
Infection[Preliminary results in the use of a new composite prosthesis in incisional hernia repair] PubMed
Inflammatory Bowel DiseasesActivator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis. PubMed
Influenza, HumanApoptosis and microglial activation in influenza encephalopathy. PubMed
Insulin ResistanceOxidative Stress in Young Zucker Rats with Impaired Glucose Tolerance is Diminished by Acarbose. PubMed
Insulin ResistancePARP-1 DEFICIENCY EXACERBATES DIET-INDUCED OBESITY IN MICE. PubMed
InsulinomaIncreased susceptibility to streptozotocin-induced beta-cell apoptosis and delayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice. PubMed
InsulinomaPoly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA. PubMed
InsulinomaRole of JNK activation in pancreatic beta-cell death by streptozotocin. PubMed
Intestinal PolyposisPoly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. PubMed
Ischemic Attack, TransientEffect of transient focal ischemia of mouse brain on energy state and NAD levels: no evidence that NAD depletion plays a major role in secondary disturbances of energy metabolism. PubMed
Ischemic Attack, TransientIschemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. PubMed
Ischemic Attack, TransientRole of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia. PubMed
Kidney DiseasesPoly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model. PubMed
Kidney Failure, ChronicAccumulation of plasma N-methyl-2-pyridone-5-carboxamide in patients with chronic renal failure. PubMed
Kidney Failure, ChronicAccumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure. PubMed
Kidney NeoplasmsDevelopment of flexible-heteroarotinoids for kidney cancer. PubMed
Kidney NeoplasmsPenta-O-galloyl-?-D-glucose attenuates cisplatin-induced nephrotoxicity via reactive oxygen species reduction in renal epithelial cells and enhances antitumor activity in Caki-2 renal cancer cells. PubMed
Laryngeal NeoplasmsReduced poly(ADP-ribosyl)ation in lymphocytes of laryngeal cancer patients: results of a case-control study. PubMed
LeiomyomaEnhanced polyadenosine diphosphate-ribosylation in gonadotropin-releasing hormone agonist-treated uterine leiomyoma. PubMed
LeiomyomaProgesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells. PubMed
LeiomyomaSelective progesterone receptor modulator asoprisnil induces endoplasmic reticulum stress in cultured human uterine leiomyoma cells. PubMed
LeiomyosarcomaNovel approaches to treatment of leiomyosarcomas. PubMed
LeukemiaA112, a tamibarotene dimethylaminoethyl ester, may inhibit human leukemia cell growth more potently than tamibarotene. PubMed
LeukemiaALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line. PubMed
LeukemiaApoptosis and perturbation of cell cycle progression in an acidic environment after hyperthermia. PubMed
LeukemiaApoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin. PubMed
Leukemiabeta-Lapachone (LAPA) Decreases Cell Viability and Telomerase Activity in Leukemia Cells: Suppression of Telomerase Activity by LAPA. PubMed
LeukemiaBiochemical pathways of apoptosis: nicotinamide adenine dinucleotide-deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-kD apoptotic protease and DNA fragmentation. PubMed
LeukemiaBreaking chemoresistance and radioresistance with [213Bi]anti-CD45 antibodies in leukemia cells. PubMed
LeukemiaCelastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells. PubMed
LeukemiaCharacterization of antibodies specific for the caspase cleavage site on poly(ADP-ribose) polymerase: specific detection of apoptotic fragments and mapping of the necrotic fragments of poly(ADP-ribose) polymerase. PubMed
LeukemiaCombination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide-resistant cancer cells. PubMed
LeukemiaCytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. PubMed
LeukemiaDietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. PubMed
LeukemiaDown-modulation of poly(ADP-ribose) polymerase-1 (PARP-1) in human TUR leukemia cells restores transcriptional responsiveness for differentiation and cell cycle arrest. PubMed
LeukemiaInduction of G2/M phase arrest and apoptosis of human leukemia cells by potent antitumor triazoloacridinone C-1305. PubMed
LeukemiaInhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death. PubMed
LeukemiaInhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells. PubMed
LeukemiaInteractive effects of histone deacetylase inhibitors and TRAIL on apoptosis in human leukemia cells: involvement of both death receptor and mitochondrial pathways. PubMed
LeukemiaLupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al. PubMed
LeukemiaMethadone, commonly used as maintenance medication for outpatient treatment of opioid dependence, kills leukemia cells and overcomes chemoresistance. PubMed
LeukemiaMethylene chloride fraction of Scutellaria barbata induces apoptosis in human U937 leukemia cells via the mitochondrial signaling pathway. PubMed
LeukemiaOleanolic Acid Induces Apoptosis in Human Leukemia Cells through Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. PubMed
LeukemiaOverexpression of poly(ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells. PubMed
LeukemiaPeroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells. PubMed
LeukemiaPoly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity. PubMed
LeukemiaPurging effect of dibutyl phthalate on leukemia cells involves fas independent activation of caspase-3/CPP32 protease. PubMed
LeukemiaQuercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt. PubMed
LeukemiaResistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). PubMed
LeukemiaSeed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways. PubMed
LeukemiaSelenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells. PubMed
LeukemiaSequence-specific binding of poly(ADP-ribose) polymerase-1 to the human T cell leukemia virus type-I tax responsive element. PubMed
LeukemiaSynergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase. PubMed
LeukemiaSynthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. PubMed
LeukemiaThe interleukin 1beta-converting enzyme inhibitor CrmA prevents Apo1/Fas- but not glucocorticoid-induced poly(ADP-ribose) polymerase cleavage and apoptosis in lymphoblastic leukemia cells. PubMed
LeukemiaThe mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction. PubMed
LeukemiaWK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells. PubMed
LeukemiaZinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. PubMed
Leukemia, Erythroblastic, AcuteInduction of erythroid differentiation of murine erythroleukemia cells by nicotinamide and related compounds. PubMed
Leukemia, Erythroblastic, AcuteMitosis may be an obligatory route to terminal differentiation in the Friend erythroleukemia cell. PubMed
Leukemia, Lymphocytic, Chronic, B-CellCombretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage. PubMed
Leukemia, Lymphocytic, Chronic, B-CellPoly(ADP-ribose) polymerase can bind melphalan damaged DNA. PubMed
Leukemia, Lymphocytic, Chronic, B-CellRole of nicotinamide adenine dinucleotide and adenosine triphosphate in glucocorticoid-induced cytotoxicity in susceptible lymphoid cells. PubMed
Leukemia, MyeloidAntiproliferation effects of ponicidin on human myeloid leukemia cells in vitro. PubMed
Leukemia, MyeloidPK11195, an isoquinoline carboxamide ligand of the mitochondrial benzodiazepine receptor, increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro. PubMed
Leukemia, Myeloid[Apoptosis of myeloid leukemia cell line HL60 induced by Bortezomib, a proteasome inhibitor] PubMed
Leukemia, Myeloid, AcuteInhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. PubMed
Leukemia, Myeloid, AcuteRegulation of the nuclear proteasome activity in myelomonocytic human leukemia cells after adriamycin treatment. PubMed
Leukemia, Myeloid, AcuteThe vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance. PubMed
Leukemia, Promyelocytic, AcuteOverexpression of poly(ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells. PubMed
Leukemia, T-CellFermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells. PubMed
Leukemia, T-CellIdentification of poly(ADP-ribose) polymerase as a transcriptional coactivator of the human T-cell leukemia virus type 1 Tax protein. PubMed
Leukemia, T-CellSequence-specific binding of poly(ADP-ribose) polymerase-1 to the human T cell leukemia virus type-I tax responsive element. PubMed
LeukoencephalopathiesNeuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia. PubMed
LeukostasisPeroxynitrite decomposition catalyst, FP15, and poly(ADP-ribose) polymerase inhibitor, PJ34, inhibit leukocyte entrapment in the retinal microcirculation of diabetic rats. PubMed
Lewy Body DiseaseThe expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease. PubMed
Li-Fraumeni SyndromeDNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. PubMed
LiposarcomaGrowth inhibitory effect of quercetin on SW 872 human liposarcoma cells. PubMed
Liver DiseasesContribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid. PubMed
Liver DiseasesOval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. PubMed
Liver FailureCytosolic phospholipase A(2)? protects against Fas- but not LPS-induced liver injury. PubMed
Liver NeoplasmsA novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. PubMed
Liver NeoplasmsInhibition of poly (ADP-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells. PubMed
Liver NeoplasmsMale rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity. PubMed
Liver NeoplasmsPJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells. PubMed
Liver NeoplasmsSynergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. PubMed
Lung DiseasesPoly(ADP-ribosyl)ation in asthma and other lung diseases. PubMed
Lung DiseasesUse of transposon mutants to assess the role of exoenzyme S in chronic pulmonary disease due to Pseudomonas aeruginosa. PubMed
Lung InjuryAlteration of pulmonary structure by Pseudomonas aeruginosa exoenzyme S. PubMed
Lung InjuryEffects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. PubMed
Lung InjuryExcitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase. PubMed
Lung InjuryInhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats. PubMed
Lung InjuryInhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury. PubMed
Lung InjuryInhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury. PubMed
Lung InjuryINO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation. PubMed
Lung InjuryPoly(ADP-ribose) polymerase-1 (PARP-1) controls lung cell proliferation and repair after hyperoxia-induced lung damage. PubMed
Lung InjuryPreexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes. PubMed
Lung InjuryProlonged poly(ADP-ribose) polymerase-1 activity regulates JP-8-induced sustained cytokine expression in alveolar macrophages. PubMed
Lung InjuryProtective effect of orally administered carnosine on bleomycin-induced lung injury. PubMed
Lung InjuryPulmonary and renal protection: targeting PARP to ventilator-induced lung and kidney injury? PubMed
Lung InjuryRenal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP pathway. PubMed
Lung InjuryRole of PARP on iNOS pathway during endotoxin-induced acute lung injury. PubMed
Lung InjuryRole of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass. PubMed
Lung InjuryTherapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury. PubMed
Lung NeoplasmsActivation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. PubMed
Lung NeoplasmsAdenosine diphosphate ribosyl transferase responses to a standardized dose of hydrogen peroxide in the mononuclear leukocytes of patients with a diagnosis of cancer. PubMed
Lung NeoplasmsAntitumor effect of BPR-DC-2, a novel synthetic cyclic cyanoguanidine derivative, involving the inhibition of MDR-1 expression and down-regulation of p-AKT and PARP-1 in lung cancer. PubMed
Lung NeoplasmsBCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death. PubMed
Lung NeoplasmsBeetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis. PubMed
Lung NeoplasmsChromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. PubMed
Lung NeoplasmsDNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. PubMed
Lung NeoplasmsEthnic differences in poly(ADP-ribose) polymerase pseudogene genotype distribution and association with lung cancer risk. PubMed
Lung NeoplasmsFunctional Polymorphisms of Base Excision Repair Genes XRCC1 and APEX1 Predict Risk of Radiation Pneumonitis in Patients with Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy. PubMed
Lung NeoplasmsInhibition of poly(ADP-ribose) polymerase (PARP) induces apoptosis in lung cancer cell lines. PubMed
Lung NeoplasmsInhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. PubMed
Lung NeoplasmsNo association between haplotypes of three variants (codon 81, 284, and 762) in poly(ADP-ribose) polymerase gene and risk of primary lung cancer. PubMed
Lung NeoplasmsNon-small and small cell lung carcinoma cell lines exhibit cell type-specific sensitivity to edelfosine-induced cell death and different cell line-specific responses to edelfosine treatment. PubMed
Lung NeoplasmsP-glycoprotein-independent apoptosis induction by a novel synthetic compound, MMPT [5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone]. PubMed
Lung NeoplasmsPARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer. PubMed
Lung NeoplasmsParticipation of poly(ADP-ribose) polymerase in the drug sensitivity in human lung cancer cell lines. PubMed
Lung NeoplasmsPoly(ADP-ribose) polymerase-1 regulates vimentin expression in lung cancer cells. PubMed
Lung NeoplasmsPolymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. PubMed
Lung NeoplasmsPutative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). PubMed
Lung NeoplasmsReplication-dependent ?-H2AX formation is involved in docetaxel-induced apoptosis in NSCLC A549 cells. PubMed
Lung NeoplasmsStimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells. PubMed
Lung NeoplasmsSynergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase. PubMed
Lung Neoplasms[Distribution of poly(ADP-ribose) polymerase pseudogene polymorphism and association with susceptibility to lung cancer in Chinese people] PubMed
Lupus Erythematosus, SystemicAltered autoantigen structure in Sjögren's syndrome: implications for the pathogenesis of autoimmune tissue damage. PubMed
Lupus Erythematosus, SystemicAssociation of poly(ADP-ribose) polymerase 1 and a novel candidate locus, LOC127086, with systemic lupus erythematosus. PubMed
Lupus Erythematosus, SystemicAutoantibodies reacting with poly(ADP-ribose) and with a zinc-finger functional domain of poly(ADP-ribose) polymerase involved in the recognition of damaged DNA. PubMed
Lupus Erythematosus, SystemicConstitutive abnormal expression of RasGRP-1 isoforms and low expression of PARP-1 in patients with systemic lupus erythematosus. PubMed
Lupus Erythematosus, SystemicPARP activity and NAD concentration in PMC from patients affected by systemic sclerosis and lupus erythematosus. PubMed
Lupus Erythematosus, SystemicPARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus. PubMed
Lupus Erythematosus, SystemicPoly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus. PubMed
Lupus Erythematosus, SystemicPoly(ADP-ribose) polymerase activity in systemic lupus erythematosis and systemic sclerosis. PubMed
Lupus Erythematosus, SystemicPoly(ADP-ribose) polymerase alleles in French Caucasians are associated neither with lupus nor with primary antiphospholipid syndrome. GRAID Research Group. Group for Research on Auto-Immune Disorders. PubMed
Lupus Erythematosus, SystemicPoly(ADP-ribose) polymerase polymorphisms are not a genetic risk factor for systemic lupus erythematosus in German Caucasians. PubMed
LymphomaApoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. PubMed
LymphomaApoptosis in the absence of cytochrome c accumulation in the cytosol. PubMed
LymphomaATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. PubMed
LymphomaB-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. PubMed
LymphomaCharacterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different flip isoforms. PubMed
LymphomaChk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition. PubMed
LymphomaCombined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice. PubMed
LymphomaCorrelation of poly(ADP-ribose)polymerase and p53 expression levels in high-grade lymphomas. PubMed
LymphomaDimethyl sulfoxide activates tumor necrosis factor?-p53 mediated apoptosis and down regulates d-fructose-6-phosphate-2-kinase and lactate dehydrogenase-5 in Dalton's lymphoma in vivo. PubMed
LymphomaEffect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells. PubMed
LymphomaEnhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. PubMed
LymphomaFADD expression and caspase activation in B-cell lymphomas resistant to Fas-mediated apoptosis. PubMed
LymphomaGranzyme B leakage-induced apoptosis is a crucial mechanism of cell death in nasal-type NK/T-cell lymphoma. PubMed
LymphomaImmunohistochemical detection of poly(ADP-ribose) polymerase inhibition by ABT-888 in patients with refractory solid tumors and lymphomas. PubMed
LymphomaInhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks. PubMed
LymphomaInhibitors of poly(ADP-ribose) polymerase increase antibody class switching. PubMed
LymphomaLigation of CD40 potentiates Fas-mediated activation of the cysteine protease CPP32, cleavage of its death substrate PARP, and apoptosis in Ramos-Burkitt lymphoma B cells. PubMed
LymphomaLigation of CD40 rescues Ramos-Burkitt lymphoma B cells from calcium ionophore- and antigen receptor-triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP. PubMed
LymphomaModulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells. PubMed
LymphomaModulation of the antiproliferative activity of anticancer drugs in hematopoietic tumor cell lines by the poly(ADP-ribose) polymerase inhibitor 6(5H)-phenanthridinone. PubMed
LymphomaMotexafin gadolinium induces mitochondrially-mediated caspase-dependent apoptosis. PubMed
LymphomaNovel targeted therapeutics: inhibitors of MDM2, ALK and PARP. PubMed
LymphomaPARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis. PubMed
LymphomaPhase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas. PubMed
LymphomaPoly(ADP-ribose) polymerase inhibitors combined with external beam and radioimmunotherapy to treat aggressive lymphoma. PubMed
LymphomaRole of nicotinamide adenine dinucleotide and adenosine triphosphate in glucocorticoid-induced cytotoxicity in susceptible lymphoid cells. PubMed
LymphomaSystemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. PubMed
LymphomaThe effects of benzamide ADP-ribosyl transferase inhibitors on cell survival and DNA strand-break repair in irradiated mammalian cells. PubMed
Lymphoma, B-CellAnticancer effects of eleven triterpenoids derived from Antrodia camphorata. PubMed
Lymphoma, B-CellApoptosis in B-cell lymphomas and reactive lymphoid tissues always involves activation of caspase 3 as determined by a new in situ detection method. PubMed
Lymphoma, B-CellChromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. PubMed
Lymphoma, B-CellInhibitors of poly(ADP-ribose) polymerase increase antibody class switching. PubMed
Lymphoma, B-CellInulin Induces Dendritic Cells Apoptosis through the Caspase-Dependent Pathway and Mitochondrial Dysfunction. PubMed
Lymphoma, B-CellToona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma. PubMed
Lymphoma, Large B-Cell, DiffuseMechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells. PubMed
Lymphoma, Mantle-CellATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. PubMed
Lymphoma, Mantle-CellEnhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. PubMed
Lymphoma, Mantle-CellInhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks. PubMed
Lymphoma, Non-HodgkinCorrelation of poly(ADP-ribose)polymerase and p53 expression levels in high-grade lymphomas. PubMed
Lymphoma, Non-HodgkinPARP-1 protein expression in glioblastoma multiforme. PubMed
Lymphoma, Non-HodgkinPARP-1 Val762Ala polymorphism is associated with reduced risk of non-Hodgkin lymphoma in Korean males. PubMed
Lymphoma, Non-HodgkinPoly(ADP-ribose) polymerase inhibitors combined with external beam and radioimmunotherapy to treat aggressive lymphoma. PubMed
Lymphoma, Non-HodgkinResponse of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation. PubMed
Lymphoma, T-CellMolecular cloning of a functional murine arginine-specific mono-ADP-ribosyltransferase and its expression in lymphoid cells. PubMed
MalariaThe pathophysiology of falciparum malaria. PubMed
MastocytosisKit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells. PubMed
MedulloblastomaCentral nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. PubMed
MedulloblastomaCleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas. PubMed
MedulloblastomaExpression of Gli1 and PARP1 in medulloblastoma: an immunohistochemical study of 65 cases. PubMed
MedulloblastomaMedulloblastoma in mice lacking p53 and PARP: all roads lead to Gli. PubMed
MedulloblastomaNull mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice. PubMed
MedulloblastomaPARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. PubMed
MedulloblastomaPARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma. PubMed
MelanomaA role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression. PubMed
MelanomaAltered Expression of the Poly(ADP-Ribosyl)ation Enzymes in Uveal Melanoma and Regulation of PARG Gene Expression by the Transcription Factor ERM. PubMed
MelanomaAnti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma. PubMed
MelanomaArachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27. PubMed
MelanomaAttenuation of genotoxicity under adhesion-restrictive conditions through modulation of p53, gamma H2AX and nuclear DNA organization. PubMed
MelanomaBrain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors. PubMed
Melanomac-Myc is able to sensitize human melanoma cells to diverse apoptotic triggers. PubMed
MelanomaCombination of PDT and inhibitor treatment affects melanoma cells and spares keratinocytes. PubMed
MelanomaCyclosporine A and its non-immunosuppressive derivative NIM811 induce apoptosis of malignant melanoma cells in in vitro and in vivo studies. PubMed
MelanomaDeficiency of C-C chemokine receptor 5 suppresses tumor development via inactivation of NF-?B and upregulation of IL-1Ra in melanoma model. PubMed
MelanomaDifferential regulation of CXC ligand 1 transcription in melanoma cell lines by poly(ADP-ribose) polymerase-1. PubMed
MelanomaEndothelin receptor B inhibition triggers apoptosis and enhances angiogenesis in melanomas. PubMed
MelanomaFatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells. PubMed
MelanomaGenetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma. PubMed
MelanomaHuman melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by Cisplatin. PubMed
MelanomaInhibition of melanoma growth and metastasis by ATF2-derived peptides. PubMed
MelanomaInhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line. PubMed
MelanomaInhibition of Poly(ADP-Ribose) Polymerase Enhances the Effect of Chemotherapy in an Animal Model of Regional Therapy for the Treatment of Advanced Extremity Malignant Melanoma. PubMed
MelanomaInhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor. PubMed
MelanomaIsolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells. PubMed
MelanomaLauroside B, a megastigmane glycoside from Laurus nobilis (bay laurel) leaves, induces apoptosis in human melanoma cell lines by inhibiting NF-?B activation. PubMed
MelanomaLoss of function of vascular smooth muscle cells by nitric oxide-dependent and -independent interactions with tumorigenic cells. PubMed
MelanomaMetabolic utilization of exogenous pyruvate by mutant p53(R175H) human melanoma cells promotes survival under glucose depletion. PubMed
MelanomaMitochondrial transmembrane potential in spontaneous and camptothecin-induced apoptosis of melanotic and amelanotic melanoma cells. PubMed
MelanomaMurine melanoma cell differentiation and melanogenesis induced by poly(ADP-ribose) polymerase inhibitors. PubMed
MelanomaOverexpression of HSP70 prevents ultraviolet B-induced apoptosis of a human melanoma cell line. PubMed
MelanomaPharmacological Inhibition of Poly(ADP-ribose) Polymerase (PARP) Activity in PARP-1 Silenced Tumour Cells Increases Chemosensitivity to Temozolomide and to a N3-Adenine Selective Methylating Agent. PubMed
MelanomaPharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent. PubMed
MelanomaPoly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region. PubMed
MelanomaPoly(Adenosine Diphosphate-Ribose) Polymerase-1 Expression in Cutaneous Malignant Melanomas as a New Molecular Marker of Aggressive Tumor. PubMed
MelanomaPoly(ADP-ribose) in the skin and in melanomas. PubMed
MelanomaPolymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population. PubMed
MelanomaRadiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer Vaccine. PubMed
MelanomaRIN1 exhibits oncogenic property to suppress apoptosis and its aberrant accumulation associates with poor prognosis in melanoma. PubMed
MelanomaStable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity. PubMed
MelanomaSurvivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response. PubMed
MelanomaSystemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. PubMed
MelanomaTemozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1. PubMed
MelanomaTemozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53. PubMed
MelanomaThe activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell. PubMed
MelanomaThe gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines. PubMed
MelanomaThe melanoma specific 9.2.27PE immunotoxin efficiently kills melanoma cells in vitro. PubMed
MelanomaTumor apoptosis induced by ruthenium(II)-ketoconazole is enhanced in nonsusceptible carcinoma by monoclonal antibody to EGF receptor. PubMed
Meniere DiseasePoly(ADP-ribose) polymerase-1 (PARP-1) longer alleles spanning the promoter region may confer protection to bilateral Meniere's disease. PubMed,  PubMed
MeningitisSNPs in DNA repair genes associated to meningitis and host immune response. PubMed
Meningitis, BacterialMeningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase. PubMed
Meningitis, PneumococcalMeningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase. PubMed
MesotheliomaTaurolidine and oxidative stress: a rationale for local treatment of mesothelioma. PubMed
Metabolic DiseasesPARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation. PubMed
Metabolic DiseasesThe NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. PubMed
Monoclonal Gammopathy of Undetermined SignificanceAltered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma. PubMed
Mouth NeoplasmsAnticancer effects of eleven triterpenoids derived from Antrodia camphorata. PubMed
Mouth NeoplasmsNorcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio. PubMed
Mouth NeoplasmsOverexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer. PubMed
Mouth NeoplasmsThe Apoptotic Effect of the Hexane Extract of Rheum undulatum L. in Oral Cancer Cells through the Down-regulation of Specificity Protein 1 and Survivin. PubMed
MPTP PoisoningA novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism. PubMed
MPTP PoisoningPoly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. PubMed
MPTP PoisoningSPATIAL AND FUNCTIONAL RELATIONSHIP BETWEEN POLY(ADP-RIBOSE) POLYMERASE-1 AND POLY(ADP-RIBOSE) GLYCOHYDROLASE IN THE BRAIN. PubMed
Multiple MyelomaA novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. PubMed
Multiple MyelomaAltered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma. PubMed
Multiple MyelomaBortezomib-induced 'BRCAness' sensitizes multiple myeloma cells to PARP inhibitors. PubMed
Multiple MyelomaProteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma. PubMed
Multiple SclerosisInhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death. PubMed
Multiple SclerosisPARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. PubMed
Multiple SclerosisPoly(ADP-ribose) polymerase-1 activation in a primate model of multiple sclerosis. PubMed
Muscular AtrophyAbsence of Caspase-3 Protects Against Denervation Induced Skeletal Muscle Atrophy. PubMed
MyelitisEffects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury. PubMed
MyelitisIL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis. PubMed
MyelitisInhibition of tyrosine kinase-mediated cellular signalling by Tyrphostins AG126 and AG556 modulates secondary damage in experimental spinal cord trauma. PubMed
MyelitisInhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. PubMed
Myelodysplastic SyndromesInhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. PubMed
Myocardial InfarctionA novel and orally active poly(ADP-ribose) polymerase inhibitor, KR-33889 [2-[methoxycarbonyl(4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic acid amide], attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia. PubMed
Myocardial InfarctionA randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial. PubMed
Myocardial InfarctionActivation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. PubMed
Myocardial InfarctionActivation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction. PubMed
Myocardial InfarctionAcute myocardial infarction induced increases in plasma tumor necrosis factor-alpha and interleukin-10 are associated with the activation of poly(ADP-ribose) polymerase of circulating mononuclear cell. PubMed
Myocardial InfarctionEffects of 3-aminobenzamide on expressions of poly (ADP ribose) polymerase and apoptosis inducing factor in cardiomyocytes of rats with acute myocardial infarction. PubMed
Myocardial InfarctionImidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. PubMed
Myocardial InfarctionIncreased Poly (ADP-ribosyl)ation in Peripheral Leukocytes and the Reperfused Myocardium Tissue of Rats with Ischemia/Reperfusion Injury: Prevention by 3-Aminobenzamide Treatment. PubMed
Myocardial InfarctionInhibition of the activity of poly (ADP-ribose) polymerase reduces heart ischaemia/reperfusion injury via suppressing JNK-mediated AIF translocation. PubMed
Myocardial InfarctionInhibition of the activity of Poly(ADP-Ribose) Polymerase reduces heart ischemia/reperfusion injury via suppressing JNK mediated AIF translocation. PubMed
Myocardial InfarctionLocal Administration of the Poly ADP-Ribose Polymerase (PARP) Inhibitor, PJ34 During Hindlimb Ischemia Modulates Skeletal Muscle Reperfusion Injury. PubMed
Myocardial InfarctionMyocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption. PubMed
Myocardial InfarctionNatural Inhibitors of Poly(ADP-ribose) Polymerase-1. PubMed
Myocardial InfarctionPARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway. PubMed
Myocardial InfarctionPoly (ADP-ribose) polymerase, nitric oxide and cell death. PubMed
Myocardial InfarctionPoly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator. PubMed
Myocardial InfarctionPoly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update. PubMed
Myocardial InfarctionPoly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor. PubMed
Myocardial InfarctionPoly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. PubMed
Myocardial InfarctionPoly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications. PubMed
Myocardial InfarctionPotential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors. PubMed
Myocardial InfarctionRole of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. PubMed
Myocardial InfarctionThe functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders. PubMed
Myocardial InfarctionThe role of Akt and mitogen-activated protein kinase systems in the protective effect of poly(ADP-ribose) polymerase inhibition in Langendorff perfused and in isoproterenol-damaged rat hearts. PubMed
Myocardial IschemiaA novel and orally active poly(ADP-ribose) polymerase inhibitor, KR-33889 [2-[methoxycarbonyl(4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic acid amide], attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia. PubMed
Myocardial IschemiaAbsence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury. PubMed
Myocardial IschemiaActivation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. PubMed
Myocardial IschemiaDevelopment of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors. PubMed
Myocardial IschemiaDevelopment of a miniaturized assay for the high-throughput screening program for poly(ADP-ribose) polymerase-1. PubMed
Myocardial IschemiaDifferential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1. PubMed
Myocardial IschemiaIn vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters. PubMed
Myocardial IschemiaInhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy. PubMed
Myocardial IschemiaInhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration. PubMed
Myocardial IschemiaMyocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption. PubMed
Myocardial IschemiaPoly(ADP-ribose) polymerase inhibitors. PubMed
Myocardial IschemiaPrevalent role of Akt and ERK activation in cardioprotective effect of Ca(2+) channel- and beta-adrenergic receptor blockers. PubMed
Myocardial IschemiaSuppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences. PubMed
Myocardial IschemiaTherapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size. PubMed
Myocardial Reperfusion InjuryAbsence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury. PubMed
Myocardial Reperfusion InjuryActivation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction. PubMed
Myocardial Reperfusion InjuryBeneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure. PubMed
Myocardial Reperfusion InjuryBeneficial effects of poly (ADP-ribose) polymerase inhibition against the reperfusion injury in heart transplantation. PubMed
Myocardial Reperfusion InjuryDifferential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1. PubMed
Myocardial Reperfusion InjuryInhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration. PubMed
Myocardial Reperfusion InjuryPharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. PubMed
Myocardial Reperfusion InjuryRole of nitrosative stress and poly(ADP-ribose) polymerase activation in myocardial reperfusion injury. PubMed
Myocardial Reperfusion InjurySuppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences. PubMed
nad+ adp-ribosyltransferase deficiencyA possible role for telomerase RNA and telomere length in global mitotic recombination. PubMed
nad+ adp-ribosyltransferase deficiencyAnalysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients. PubMed
nad+ adp-ribosyltransferase deficiencyChanges in poly(ADP-ribose) level modulate the kinetics of DNA strand break rejoining. PubMed
nad+ adp-ribosyltransferase deficiencyChromosomal aberrations in PARP(-/-) mice: genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA. PubMed
nad+ adp-ribosyltransferase deficiencyCytokine-mediated ?-cell damage in PARP-1-deficient islets. PubMed
nad+ adp-ribosyltransferase deficiencyDietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells. PubMed
nad+ adp-ribosyltransferase deficiencyDifferential susceptibility of normal and PARP knock-out mouse fibroblasts to proteasome inhibitors. PubMed
nad+ adp-ribosyltransferase deficiencyDNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. PubMed
nad+ adp-ribosyltransferase deficiencyEffect of PARP-1 deficiency on DNA damage and repair in human bronchial epithelial cells exposed to Benzo(a)pyrene. PubMed
nad+ adp-ribosyltransferase deficiencyEffects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy antigen receptor for chemokines. PubMed
nad+ adp-ribosyltransferase deficiencyGenetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors. PubMed
nad+ adp-ribosyltransferase deficiencyIncreased Foxp3+ regulatory T cells in poly(ADP-Ribose) polymerase-1 deficiency. PubMed
nad+ adp-ribosyltransferase deficiencyInhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy. PubMed
nad+ adp-ribosyltransferase deficiencyMisregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase. PubMed
nad+ adp-ribosyltransferase deficiencyMutagenic effects of poly (ADP-ribose) polymerase-1 deficiency in transgenic mice. PubMed
nad+ adp-ribosyltransferase deficiencyNormal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability. PubMed
nad+ adp-ribosyltransferase deficiencyOpposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. PubMed
nad+ adp-ribosyltransferase deficiencyPARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model. PubMed
nad+ adp-ribosyltransferase deficiencyParp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent. PubMed
nad+ adp-ribosyltransferase deficiencyParp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice. PubMed
nad+ adp-ribosyltransferase deficiencyParp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. PubMed
nad+ adp-ribosyltransferase deficiencyPARP-1 DEFICIENCY EXACERBATES DIET-INDUCED OBESITY IN MICE. PubMed
nad+ adp-ribosyltransferase deficiencyParp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. PubMed
nad+ adp-ribosyltransferase deficiencyPARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. PubMed
nad+ adp-ribosyltransferase deficiencyPartial protection against collagen antibody-induced arthritis in PARP-1 deficient mice. PubMed
nad+ adp-ribosyltransferase deficiencyPoly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator. PubMed
nad+ adp-ribosyltransferase deficiencyPoly (ADP-ribose) polymerase-1 deficiency does not affect ethylnitrosourea mutagenicity in liver and testis of lacZ transgenic mice. PubMed
nad+ adp-ribosyltransferase deficiencyPoly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery. PubMed
nad+ adp-ribosyltransferase deficiencyPoly(ADP-ribose) polymerase suppression protects rheumatoid synovial fibroblasts from Fas-induced apoptosis. PubMed
nad+ adp-ribosyltransferase deficiencyPoly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation. PubMed
nad+ adp-ribosyltransferase deficiencyPoly(ADP-ribose) polymerase-1 modulates interferon-gamma-inducible protein (IP)-10 expression in murine embryonic fibroblasts by stabilizing IP-10 mRNA. PubMed
nad+ adp-ribosyltransferase deficiencyPoly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice. PubMed
nad+ adp-ribosyltransferase deficiencyPoly(ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein. PubMed
nad+ adp-ribosyltransferase deficiencyReduced stability of regularly spliced but not alternatively spliced p53 protein in PARP-deficient mouse fibroblasts. PubMed
nad+ adp-ribosyltransferase deficiencyRole of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age. PubMed
nad+ adp-ribosyltransferase deficiencyRole of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis. PubMed
nad+ adp-ribosyltransferase deficiencySyncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells. PubMed
nad+ adp-ribosyltransferase deficiencyThe BRCT domain of PARP-1 is required for immunoglobulin gene conversion. PubMed
nad+ adp-ribosyltransferase deficiencyTranscriptional regulation by poly(ADP-ribose) polymerase-1 during T cell activation. PubMed
Neoplasm Metastasis5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. PubMed
Neoplasm MetastasisA chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. PubMed
Neoplasm MetastasisDown-regulation of Notch receptor signaling pathway induces caspase-dependent and caspase-independent apoptosis in lung squamous cell carcinoma cells. PubMed
Neoplasm MetastasisGarcinol Inhibits Cell Proliferation and Promotes Apoptosis in Pancreatic Adenocarcinoma Cells. PubMed
Neoplasm MetastasisPoly(ADP-ribose)polymerase inhibition decreases angiogenesis. PubMed
Neoplasm MetastasisThe expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome. PubMed
Neoplasms1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma. PubMed
Neoplasms15-Lipoxygenase-1 induced by interleukin-4 mediates apoptosis in oral cavity cancer cells. PubMed
Neoplasms17?-androstenediol-mediated oncophagy of tumor cells by different mechanisms is determined by the target tumor. PubMed
Neoplasms18?-Glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway. PubMed
Neoplasms2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469) inhibition of topoisomerase IIbeta is not sufficient for therapeutic response in human Waldenstrom's macroglobulinemia xenograft model. PubMed
Neoplasms3,3'-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer. PubMed
Neoplasms4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. PubMed
Neoplasms5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. PubMed
Neoplasms6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. PubMed
NeoplasmsA deletion linked to a poly(ADP-ribose) polymerase gene on chromosome 13q33-qter occurs frequently in the normal black population as well as in multiple tumor DNA. PubMed
NeoplasmsA duplicated region is responsible for the poly(ADP-ribose) polymerase polymorphism, on chromosome 13, associated with a predisposition to cancer. PubMed
NeoplasmsA general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose. PubMed
NeoplasmsA high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity. PubMed
NeoplasmsA marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer. PubMed
NeoplasmsA new ADP-ribosyltransferase in human serum: significance in cancer. PubMed
NeoplasmsA novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis. PubMed
NeoplasmsA novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia. PubMed
NeoplasmsA novel sLRP6E1E2 inhibits canonical Wnt signaling, epithelial-to-mesenchymal transition, and induces mitochondria-dependent apoptosis in lung cancer. PubMed
NeoplasmsA novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. PubMed
NeoplasmsA peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis. PubMed
NeoplasmsA Phase I Combination Study of Olaparib with Cisplatin and Gemcitabine in Adults with Solid Tumors. PubMed
NeoplasmsA phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours. PubMed
NeoplasmsA Phase I Study of Veliparib in Combination with Metronomic Cyclophosphamide in Adults with Refractory Solid Tumors and Lymphomas. PubMed
NeoplasmsA Phase I, dose-finding and pharmacokinetic study of olaparib (AZD2281) in Japanese patients with advanced solid tumors*,†. PubMed
NeoplasmsA phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells. PubMed
NeoplasmsA review of PARP inhibitors: from bench to bedside. PubMed
NeoplasmsA small molecule Focal Adhesion Kinase (FAK) inhibitor, targeting Y397 site: 1-(2-Hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo. PubMed
NeoplasmsA snapshot of chemoresistance to PARP inhibitors. PubMed
NeoplasmsA synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. PubMed
NeoplasmsAberrant morphology, proliferation, and apoptosis of B-cell chronic lymphocytic leukemia cells. PubMed
NeoplasmsAbsence of Specific Cell Killing of the BRCA2-Deficient Human Cancer Cell Line CAPAN1 by Poly(ADP-ribose) Polymerase Inhibition. PubMed
NeoplasmsABT-888 confers broad in vivo activity in combination with temozolomide in diverse tumors. PubMed
NeoplasmsABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. PubMed
NeoplasmsAchyranthoside H methyl ester, a novel oleanolic acid saponin derivative from Achyranthes fauriei roots, induces apoptosis in human breast cancer MCF-7 and MDA-MB-453 cells via a caspase activation pathway. PubMed
NeoplasmsAcquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways. PubMed
NeoplasmsActivation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. PubMed
NeoplasmsActivation of caspase-3-like enzymes in non-apoptotic T cells. PubMed
NeoplasmsActivation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. PubMed
NeoplasmsActivation of poly(adenosine diphosphate-ribose) polymerase in mouse tumors treated by photodynamic therapy. PubMed
NeoplasmsAcute myocardial infarction induced increases in plasma tumor necrosis factor-alpha and interleukin-10 are associated with the activation of poly(ADP-ribose) polymerase of circulating mononuclear cell. PubMed
NeoplasmsAdenosine diphosphate ribosyl transferase responses to a standardized dose of hydrogen peroxide in the mononuclear leukocytes of patients with a diagnosis of cancer. PubMed
NeoplasmsAdenoviral-mediated transfer of the TNF-related apoptosis-inducing ligand/Apo-2 ligand gene induces tumor cell apoptosis. PubMed
NeoplasmsADP-ribosylation of the G protein Rho inhibits integrin regulation of tumor cell growth. PubMed
NeoplasmsADP-ribosylation of the GTP-binding protein RhoA blocks cytoplasmic division in human myelomonocytic cells. PubMed
NeoplasmsADP-ribosylation of wild-type p53 in vitro: binding of p53 protein to specific p53 consensus sequence prevents its modification. PubMed
NeoplasmsAdvances in using PARP inhibitors to treat cancer. PubMed
NeoplasmsAdvantage of a baculovirus expression system for protein-protein interaction studies. Involvement of posttranslational phosphorylation in the interaction between wt p53 protein and poly(ADP-ribose) polymerase-1. PubMed
NeoplasmsAltered Expression of the Poly(ADP-Ribosyl)ation Enzymes in Uveal Melanoma and Regulation of PARG Gene Expression by the Transcription Factor ERM. PubMed
NeoplasmsAn emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions. PubMed
NeoplasmsAn enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors. PubMed
NeoplasmsAn Epstein-Barr virus positive natural killer lymphoma xenograft derived for drug testing. PubMed
NeoplasmsAn oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis. PubMed
NeoplasmsAnalysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients. PubMed
NeoplasmsAnalysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines. PubMed
NeoplasmsAnti-androgen receptor signaling and prostate cancer inhibitory effects of sucrose- and benzophenone-compounds. PubMed
NeoplasmsAnti-cancer action of 4-iodo-3-nitrobenzamide in combination with buthionine sulfoximine: inactivation of poly(ADP-ribose) polymerase and tumor glycolysis and the appearance of a poly(ADP-ribose) polymerase protease. PubMed
NeoplasmsAnti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. PubMed
NeoplasmsAntiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors. PubMed
NeoplasmsAnticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric G{alpha}/G{beta}{gamma} Protein Complex. PubMed
NeoplasmsAnticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. PubMed
NeoplasmsAnticancer mechanism of equol in 7,12-dimethylbenz(a)anthracene-treated animals. PubMed
NeoplasmsAntiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer. PubMed
NeoplasmsAntimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs. PubMed
NeoplasmsAntitumor activity of noscapine in human non-small cell lung cancer xenograft model. PubMed
NeoplasmsAntitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor. PubMed
NeoplasmsAntitumor efficacy profile of PKI-402, a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor. PubMed
NeoplasmsAntitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities. PubMed
NeoplasmsAPOMAB, a La-specific monoclonal antibody, detects the apoptotic tumor response to life-prolonging and DNA-damaging chemotherapy. PubMed
NeoplasmsApoptosis induced by ID6105, a new anthracycline (11-hydroxyaclacinomycin X, Hyrubicin), and its anti-tumor effects on experimental tumor models. PubMed
NeoplasmsApoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response. PubMed
NeoplasmsApoptosis induction in prostate cancer cells and xenografts by combined treatment with Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand and CPT-11. PubMed
NeoplasmsApoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. PubMed
NeoplasmsApoptosis-related gene and protein expression in human lymphoma xenografts (Raji) after low dose rate radiation using 67Cu-2IT-BAT-Lym-1 radioimmunotherapy. PubMed
NeoplasmsApoptotic and anti-angiogenic effects of Pulsatilla koreana extract on hepatocellular carcinoma. PubMed
NeoplasmsApoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly(ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes. PubMed
NeoplasmsArsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure. PubMed
NeoplasmsAsiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade. PubMed
NeoplasmsAspirin enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in hormone-refractory prostate cancer cells through survivin down-regulation. PubMed
NeoplasmsAssociation between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis. PubMed
NeoplasmsATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. PubMed
NeoplasmsAurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition. PubMed
NeoplasmsBase excision repair, the redox environment and therapeutic implications. PubMed
NeoplasmsBaseline sister chromatid exchange in human cell lines with different levels of poly(ADP-ribose) polymerase. PubMed
NeoplasmsBcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain. PubMed
NeoplasmsBerberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PubMed
NeoplasmsBezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. PubMed
NeoplasmsBivalent smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents. PubMed
NeoplasmsBlockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. PubMed
NeoplasmsBrain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors. PubMed
NeoplasmsBRCA in breast cancer: from risk assessment to therapeutic prediction. PubMed
NeoplasmsBRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. PubMed
NeoplasmsBRCA2-Deficient CAPAN-1 Cells are Extremely Sensitive to the Inhibition of Poly (ADP-Ribose) Polymerase: An Issue of Potency. PubMed
NeoplasmsBRCAness: finding the Achilles heel in ovarian cancer. PubMed
NeoplasmsBufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. PubMed
Neoplasmsc-MYC Suppresses BIN1 to Release Poly(ADP-Ribose) Polymerase 1: A Mechanism by Which Cancer Cells Acquire Cisplatin Resistance. PubMed
NeoplasmsCalcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair. PubMed
NeoplasmsCancer during pregnancy alters the activity of rat placenta and enhances the expression of cleaved PARP, cytochrome-c and caspase 3. PubMed
NeoplasmsCapsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. PubMed
NeoplasmsCardiomyocyte death in patients with end-stage heart failure before and after support with a left ventricular assist device: low incidence of apoptosis despite ubiquitous mediators. PubMed
NeoplasmsCaspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. PubMed
NeoplasmsCaspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria. PubMed
NeoplasmsCD40- and HLA-DR-mediated cell death pathways share a lot of similarities but differ in their use of ADP-ribosyltransferase activities. PubMed
NeoplasmsCell death protection by 3-aminobenzamide: impairment of cytoskeleton function in human NK cell-mediated killing. PubMed
NeoplasmsCentral and carboxy-terminal regions of human p53 protein are essential for interaction and complex formation with PARP-1. PubMed
NeoplasmsCetuximab augments cytotoxicity with poly (adp-ribose) polymerase inhibition in head and neck cancer. PubMed
NeoplasmsChemopotentiation by PARP inhibitors in cancer therapy. PubMed
NeoplasmsChemoprevention of hormone receptor-negative breast cancer: new approaches needed. PubMed
NeoplasmsChemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice. PubMed
NeoplasmsChemotherapy-induced p53-dependent and -independent DNA damage responses are enhanced by poly(ADP-ribose) polymerase (PARP) inhibition in BRCA-proficient cancer cells. PubMed
NeoplasmsCHFR regulates the mitotic checkpoint by targeting PARP-1 for ubiquitination and degradation. PubMed
NeoplasmsCHIR-258: a potent inhibitor of FLT3 kinase in experimental tumor xenograft models of human acute myelogenous leukemia. PubMed
NeoplasmsCleavage of Poly(ADP-ribose) polymerase measured in situ in individual cells: relationship to DNA fragmentation and cell cycle position during apoptosis. PubMed
NeoplasmsCleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatment with N-nitrosomorpholine and cyproterone acetate. PubMed
NeoplasmsCleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas. PubMed
NeoplasmsClinical perspectives of PARP inhibitors. PubMed
NeoplasmsClinical poly(ADP-ribose) polymerase inhibitors for the treatment of cancer. PubMed
NeoplasmsClinical trials and future potential of targeted therapy for ovarian cancer. PubMed
NeoplasmsCo-regulated expression of dbl and poly(ADP-ribose) polymerase in Ewing's sarcoma cells and dbl-transformed NIH3T3 fibroblasts. PubMed
NeoplasmsColorectal cancers differ in respect of PARP-1 protein expression. PubMed
NeoplasmsCombination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin. PubMed
NeoplasmsCombined Effect of Hsp90 Inhibitor Geldanamycin and Parthenolide via Reactive Oxygen Species-Mediated Apoptotic Process on Epithelial Ovarian Cancer Cells. PubMed
NeoplasmsCombined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells. PubMed
NeoplasmsComparative status of activated ERK1/2 and PARP cleavage in human gliomas. PubMed
NeoplasmsCompromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. PubMed
NeoplasmsConsumer Beware: A Systematic Assessment of Potential Bias in the Lay Electronic Media to Examine the Portrayal of 'PARP' Inhibitors for Cancer Treatment. PubMed
NeoplasmsContextual synthetic lethality of cancer cell kill based on the tumor microenvironment. PubMed
NeoplasmsConverting cancer mutations into therapeutic opportunities. PubMed
NeoplasmsCordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP. PubMed
NeoplasmsCoxiella burnetii inhibits apoptosis in human THP-1 cells and monkey primary alveolar macrophages. PubMed
NeoplasmsCritical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells. PubMed
NeoplasmsCrosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia. PubMed
NeoplasmsCrystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888. PubMed
NeoplasmsCrystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. PubMed
NeoplasmsCucurbitacins as inducers of cell death and a rich source of potential anticancer compounds. PubMed
NeoplasmsCurrent development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology. PubMed
NeoplasmsCurrent Treatment Options in Triple Negative Breast Cancer. PubMed
NeoplasmsCyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. PubMed
NeoplasmsCytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts. PubMed
NeoplasmsCytotoxic gold compounds: synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1. PubMed
NeoplasmsCytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. PubMed
NeoplasmsCytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC. PubMed
NeoplasmsDefective homologous recombination in human cancers. PubMed
NeoplasmsDeficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition. PubMed
NeoplasmsDependence of trans-ADP-ribosylation and nuclear glycolysis on the Arg 34-ATP complex of Zn2+ finger I of poly-ADP-ribose polymerase-1. PubMed
NeoplasmsDevelopment of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer. PubMed
NeoplasmsDevelopment of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. PubMed
NeoplasmsDevelopment of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors. PubMed
NeoplasmsDevelopment of PARP inhibitors in oncology. PubMed
NeoplasmsDevelopment of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells. PubMed
NeoplasmsDifferences in the cellular response and signaling pathways of cisplatin and BBR3464 ([[trans-PtCl(NH3)(2)]2mu-(trans-Pt(NH3)(2)(H2N(CH2)(6)-NH2)2)]4+) influenced by copper homeostasis. PubMed
NeoplasmsDifferential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability. PubMed
NeoplasmsDifferential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. PubMed
NeoplasmsDifferential induction of apoptosis and MAP kinase signaling by mitochondrial toxicants in drug-sensitive compared to drug-resistant B-lineage lymphoid cell lines. PubMed
NeoplasmsDifferential radiosensitization by the poly(ADP-ribose) transferase inhibitor 3-aminobenzamide in human tumor cells of varying radiosensitivity. PubMed
NeoplasmsDirect current electrical fields induce apoptosis in oral mucosa cancer cells by NADPH oxidase-derived reactive oxygen species. PubMed
NeoplasmsDirected therapy of subtypes of triple-negative breast cancer. PubMed,  PubMed
NeoplasmsDiscovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. PubMed
NeoplasmsDiscovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer. PubMed
NeoplasmsDiscovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. PubMed
NeoplasmsDiscovery and Structure-Activity Relationships of Modified Salicylanilides as Cell Permeable Inhibitors of Poly(ADP-ribose) Glycohydrolase (PARG). PubMed
NeoplasmsDiscovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors. PubMed
NeoplasmsDiscovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. PubMed
NeoplasmsDISPOSITION AND DRUG-DRUG INTERACTION POTENTIAL OF VELIPARIB (ABT-888), A NOVEL AND POTENT INHIBITOR OF POLY(ADP-RIBOSE) POLYMERASE. PubMed
NeoplasmsDNA repair deficiency as a therapeutic target in cancer. PubMed
NeoplasmsDNA repair factors and telomere-chromosome integrity in mammalian cells. PubMed
NeoplasmsDNA repair signature is associated with anthracycline response in triple negative breast cancer patients. PubMed
NeoplasmsDNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. PubMed
NeoplasmsDNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. PubMed
NeoplasmsDNA-binding properties of poly(ADP-ribose) polymerase: a target for anticancer therapy. PubMed
NeoplasmsDNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin. PubMed
NeoplasmsDose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol. PubMed
NeoplasmsDown-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells. PubMed
NeoplasmsDown-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma. PubMed
NeoplasmsEffect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells. PubMed
NeoplasmsEffect of curcumin on irradiated and estrogen-transformed human breast cell lines. PubMed
NeoplasmsEffect of hyperthermia and chemotherapeutic agents on TRAIL-induced cell death in human colon cancer cells. PubMed
NeoplasmsEffects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair. PubMed
NeoplasmsEffects of PARP inhibition on drug and Fas-induced apoptosis in leukaemic cells. PubMed
NeoplasmsEffects of poly(ADP-ribose) polymerase inhibition on cell death and chromosome damage induced by VP16 and bleomycin. PubMed
NeoplasmsEffects on apoptosis and cell cycle arrest contribute to the antitumor responses of interleukin-27 mediated by retrovirus in human pancreatic carcinoma cells. PubMed
NeoplasmsElevated poly-(ADP-ribose)-polymerase activity sensitizes retinoblastoma-deficient cells to DNA damage-induced necrosis. PubMed
NeoplasmsEndoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells. PubMed
NeoplasmsEnhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells. PubMed
NeoplasmsEnhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. PubMed
NeoplasmsEnhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes. PubMed
NeoplasmsEnhanced poly ADP-ribosylation in human leukemia lymphocytes and ovarian cancers. PubMed
NeoplasmsEnhanced polyadenosine diphosphate-ribosylation in gonadotropin-releasing hormone agonist-treated uterine leiomyoma. PubMed
NeoplasmsEnhancement of Synthetic Lethality via Combinations of ABT-888, a PARP Inhibitor, and Carboplatin In Vitro and In Vivo Using BRCA1 and BRCA2 Isogenic Models. PubMed
NeoplasmsEpstein-Barr Virus Infection and Altered Control of Apoptotic Pathways in Posttransplant Lymphoproliferative Disorders. PubMed
NeoplasmsErythropoietin-driven signalling and cell migration mediated by polyADP-ribosylation. PubMed
NeoplasmsEscin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. PubMed
NeoplasmsEthyl pyruvate administration inhibits hepatic tumor growth. PubMed
NeoplasmsEvaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment. PubMed
NeoplasmsEvaluation of tankyrase inhibition in whole cells. PubMed
NeoplasmsEvidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis. PubMed
NeoplasmsExploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer. PubMed
NeoplasmsExpression of poly (adenosine diphosphate-ribose) polymerase and p53 in epithelial ovarian cancer and their role in prognosis and disease outcome. PubMed
NeoplasmsExpression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model. PubMed
NeoplasmsExpression of poly(ADP-ribose) polymerase in human hepatocellular carcinoma and analysis of biopsy specimens obtained under sonographic guidance. PubMed
NeoplasmsExtract of Solanum muricatum (Pepino/CSG) inhibits tumor growth by inducing apoptosis. PubMed
NeoplasmsFailure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro. PubMed
NeoplasmsFailure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis. PubMed
NeoplasmsFermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells. PubMed
NeoplasmsFrequent occurrence of abnormal E-cadherin/beta-catenin protein expression in advanced gallbladder cancers and its association with decreased apoptosis. PubMed
NeoplasmsFunctional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer. PubMed
NeoplasmsFunctional overexpression of human poly(ADP-ribose) polymerase in transfected rat tumor cells. PubMed
NeoplasmsGarcinol Inhibits Cell Proliferation and Promotes Apoptosis in Pancreatic Adenocarcinoma Cells. PubMed
NeoplasmsGenetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors. PubMed
NeoplasmsGenetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. PubMed
NeoplasmsGenetic diagnosis of familial breast cancer using clonal sequencing. PubMed
NeoplasmsGenetic Dissection of PARylation in the Filamentous Fungus Neurospora crassa. PubMed
NeoplasmsGenetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. PubMed
NeoplasmsGenetic sequence variations and ADPRT haplotype analysis in French Canadian families with high risk of breast cancer. PubMed
NeoplasmsGenistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. PubMed
NeoplasmsGenomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers. PubMed
NeoplasmsGeranylgeranyl transferase inhibition stimulates anti-melanoma immune response through MHC Class I and costimulatory molecule expression. PubMed
NeoplasmsGermline mutations in RAD51D confer susceptibility to ovarian cancer. PubMed
NeoplasmsGermline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer. PubMed
NeoplasmsGlycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 gene. PubMed
NeoplasmsGrape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. PubMed
NeoplasmsGrowth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells. PubMed
NeoplasmsGuanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways. PubMed
NeoplasmsHARP?111-136 enhances radiation-induced apoptosis of U87MG glioblastoma by induction of the proapoptotic protein CHOP. PubMed
NeoplasmsHeat shock protein inhibitors increase the efficacy of measles virotherapy. PubMed
NeoplasmsHelicobacter pylori activation of PARP-1: Usurping a versatile regulator of host cellular health. PubMed
NeoplasmsHER2 Overexpression Renders Human Breast Cancers Sensitive to PARP Inhibition Independently of Any Defect in Homologous Recombination DNA Repair. PubMed
NeoplasmsHereditary breast cancer: new genetic developments, new therapeutic avenues. PubMed
NeoplasmsHereditary breast cancer: pathobiology, clinical translation, and potential for targeted cancer therapeutics. PubMed
NeoplasmsHGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. PubMed
NeoplasmsHigh energy shock waves and 5-aminolevulinic for sonodynamic therapy: effects in a syngeneic model of colon cancer. PubMed
NeoplasmsHigh incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer. PubMed
NeoplasmsHigh level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma. PubMed
NeoplasmsHigh poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer. PubMed
NeoplasmsHigh sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. PubMed
NeoplasmsHistone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers. PubMed
NeoplasmsHistone H2AX is a critical factor for cellular protection against DNA alkylating agents. PubMed
NeoplasmsHomologous recombination in cancer development, treatment and development of drug resistance. PubMed
NeoplasmsHow to kill tumor cells with inhibitors of poly(ADP-ribosyl)ation. PubMed
NeoplasmsHPMA copolymer-bound doxorubicin induces apoptosis in human ovarian carcinoma cells by a Fas-independent pathway. PubMed
NeoplasmsHuman MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2. PubMed
NeoplasmsHydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase. PubMed
NeoplasmsHypericin induced death receptor-mediated apoptosis in photoactivated tumor cells. PubMed
NeoplasmsIdentification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle. PubMed
NeoplasmsIdentification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1). PubMed
NeoplasmsIdentification of a rearrangement in the 5' upstream region of the poly(ADP-ribose) polymerase pseudogene on chromosome 13 in Ewing's sarcoma cells. PubMed
NeoplasmsIdentification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors. PubMed
NeoplasmsIdentification of poly(ADP-ribose) polymerase-1 as the OXPHOS-generated ATP sensor of nuclei of animal cells. PubMed
NeoplasmsImmunohistochemical detection of poly(ADP-ribose) polymerase inhibition by ABT-888 in patients with refractory solid tumors and lymphomas. PubMed
NeoplasmsImmunophenotypic predictive profiling of BRCA1-associated breast cancer. PubMed
NeoplasmsImpact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme. PubMed
NeoplasmsImpact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs. PubMed
NeoplasmsImpaired DNA damage response - An Achilles' heel sensitizing cancer to chemotherapy and radiotherapy. PubMed
NeoplasmsIn vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016. PubMed
NeoplasmsInactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. PubMed
NeoplasmsIncreased cell-surface receptor expression on U-937 cells induced by 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine. PubMed
NeoplasmsIncreased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints. PubMed
NeoplasmsIncreased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis. PubMed
NeoplasmsInducing Synthetic Lethality using PARP Inhibitors. PubMed
NeoplasmsInduction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol. PubMed
NeoplasmsInduction of Bax protein and degradation of lamin A during p53-dependent apoptosis induced by chemotherapeutic agents in human cancer cell lines. PubMed
NeoplasmsInduction of endonuclease-mediated apoptosis in tumor cells by C-nitroso-substituted ligands of poly(ADP-ribose) polymerase. PubMed
NeoplasmsInduction of non-small cell lung carcinoma apoptosis using soluble RGD-TRAIL by targeting the integrin receptor of tumor cells. PubMed
NeoplasmsInduction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines. PubMed
NeoplasmsInhibiteurs de la PARP : des avancées significatives dans le traitement des cancers. PubMed
NeoplasmsInhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression. PubMed
NeoplasmsInhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds. PubMed
NeoplasmsInhibition of methylazoxymethanol acetate initiation of colon carcinogenesis in rats by treatment with the poly(ADP-ribose)polymerase inhibitor 3-aminobenzamide. PubMed
NeoplasmsInhibition of neuroblastoma xenograft growth by Hsp90 inhibitors. PubMed
NeoplasmsInhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line. PubMed
NeoplasmsInhibition of poly (ADP-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells. PubMed
NeoplasmsInhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability. PubMed
NeoplasmsInhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression. PubMed
NeoplasmsInhibition of poly(ADP-RIBOSE) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species. PubMed
NeoplasmsInhibition of poly(ADP-ribose) polymerase (PARP) induces apoptosis in lung cancer cell lines. PubMed
NeoplasmsInhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis. PubMed
NeoplasmsInhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130. PubMed
NeoplasmsInhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. PubMed
NeoplasmsInhibition of Poly(ADP-Ribose) Polymerase Enhances the Effect of Chemotherapy in an Animal Model of Regional Therapy for the Treatment of Advanced Extremity Malignant Melanoma. PubMed
NeoplasmsInhibition of poly(ADP-ribose) polymerase in cancer. PubMed
NeoplasmsInhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. PubMed
NeoplasmsInhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis. PubMed
NeoplasmsInhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs. PubMed
NeoplasmsInhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma. PubMed
NeoplasmsInhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft. PubMed
NeoplasmsInhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma. PubMed
NeoplasmsInhibition of Stat3 Activity by YC-1 Enhances Chemo-Sensitivity in Hepatocellular Carcinoma. PubMed
NeoplasmsInhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor. PubMed
NeoplasmsInhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis. PubMed
NeoplasmsInhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling. PubMed
NeoplasmsInhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison. PubMed
NeoplasmsIniparib no