Information on EC 2.1.1.49 - amine N-methyltransferase:
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EC NUMBERCOMMENTARY
2.1.1.49-

RECOMMENDED NAMEGeneOntology No.
amine N-methyltransferaseGO:0030748

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine
show the reaction diagram		----

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
methyl group transfer----

PATHWAYKEGG LinkMetaCyc Link
beta-alanine betaine biosynthesis-PWY-4021
nicotine degradation IV-PWY66-201

SYSTEMATIC NAMEIUBMB Comments
S-adenosyl-L-methionine:amine N-methyltransferaseAn enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
aromatic alkylamine-N-methyltransferaseRattus norvegicus--441353
arylamine N-methyltransferase----
methyltransferase, tryptamine----
nicotine N-methyltransferase----
tryptamine methyltransferase----
tryptamine N-methyltransferase----

CAS REGISTRY NUMBERCOMMENTARY
51377-47-0-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Bos taurusamine N-methyltransferase A441355--Manually annotated by BRENDA team
Oryctolagus cuniculusamine N-methyltransferase A and B; strain New Zealand, 10-16 week old441354--Manually annotated by BRENDA team
Oryctolagus cuniculusstrain New Zealand, 10-16 week old441352--Manually annotated by BRENDA team
Oryctolagus cuniculus New Zealandstrain New Zealand, 10-16 week old441352--Manually annotated by BRENDA team
Rattus norvegicusrats with common bile duct ligation and obstructive jaundice respectively; Sprague-Dawley strain male rats441356--Manually annotated by BRENDA team
Rattus norvegicusSprague-Dawley strain male rats441353--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 1,2,3,4-tetrahydroisoquinolineS-adenosyl-L-homocysteine + N-methyl-1,2,3,4-tetrahydroisoquinoline
show the reaction diagram		Bos taurus-amine N-methyltransferase A441355-441355?
S-adenosyl-L-methionine + 5-methyloxytryptamine?
show the reaction diagram		Oryctolagus cuniculus-higher activity with transferase A441354--?
S-adenosyl-L-methionine + 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline?
show the reaction diagram		Oryctolagus cuniculus-substrate with highest apparent kcat441354--?
S-adenosyl-L-methionine + alpha-N-methyltryptamineS-adenosyl-L-homocysteine + alpha,alpha-N,N-dimethyltryptamine
show the reaction diagram		Oryctolagus cuniculus--441354--?
S-adenosyl-L-methionine + alpha-N-methyltryptamineS-adenosyl-L-homocysteine + alpha,alpha-N,N-dimethyltryptamine
show the reaction diagram		Oryctolagus cuniculus--441352no methylation of indolic nitrogen441352?
S-adenosyl-L-methionine + alpha-N-methyltryptamineS-adenosyl-L-homocysteine + alpha,alpha-N,N-dimethyltryptamine
show the reaction diagram		Rattus norvegicus--441353N,N-dimethyltryptamine as product441353?
S-adenosyl-L-methionine + an amineS-adenosyl-L-homocysteine + an N-methylamine
show the reaction diagram		Oryctolagus cuniculus-enzymes participate in detoxication, recycling of drugs after initial demethylation441354--?
S-adenosyl-L-methionine + an amineS-adenosyl-L-homocysteine + an N-methylamine
show the reaction diagram		Rattus norvegicus-xenobiotic biotransforming enzyme, enzyme is leaked easily into the blood stream due to an increased membrane permeability of hepatocytes caused by cholestasis441356--?
S-adenosyl-L-methionine + aniline?
show the reaction diagram		Oryctolagus cuniculus-poor substrate441354--?
S-adenosyl-L-methionine + anisidine?
show the reaction diagram		Oryctolagus cuniculus-higher activity with transferase B441354--?
S-adenosyl-L-methionine + beta-phenylethylamine?
show the reaction diagram		Rattus norvegicus-5-methyltetrahydrofolate can replace S-adenosyl-L-methionine as methyl donor441353--?
S-adenosyl-L-methionine + desmethylimipramine?
show the reaction diagram		Oryctolagus cuniculus-higher activity with transferase A441354--?
S-adenosyl-L-methionine + imidazole?
show the reaction diagram		Oryctolagus cuniculus-higher activity with transferase A441354--?
S-adenosyl-L-methionine + isosalsolineS-adenosyl-L-homocysteine + N-methylisosalsoline
show the reaction diagram		Bos taurus-isosalsoline is identical with 7-hydroxy-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline, stereospecific N-methylation by amine N-methyltransferase A, (+)-(R)-enantiomer is preferentially methylated441355-441355?
S-adenosyl-L-methionine + N-methylbutylamineS-adenosyl-L-homocysteine + N,N-dimethylbutylamine
show the reaction diagram		Oryctolagus cuniculus-only transferase A441354--?
S-adenosyl-L-methionine + N-methylcyclohexylamineS-adenosyl-L-homocysteine + N,N-dimethylcyclohexylamine
show the reaction diagram		Oryctolagus cuniculus-only transferase A441354--?
S-adenosyl-L-methionine + N-methyltryptamineS-adenosyl-L-homocysteine + N,N-dimethyltryptamine
show the reaction diagram		Oryctolagus cuniculus--441354--?
S-adenosyl-L-methionine + phenyltetrahydropyridine?
show the reaction diagram		Oryctolagus cuniculus-higher activity with transferase A441354--?
S-adenosyl-L-methionine + pyrazole?
show the reaction diagram		Oryctolagus cuniculus-higher activity with transferase A441354--?
S-adenosyl-L-methionine + salsolidineS-adenosyl-L-homocysteine + N-methylsalsolidine
show the reaction diagram		Bos taurus-salsolidine is identical with 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline, stereospecific N-methylation by amine N-methyltransferase A, (-)-(S)-enantiomer is preferentially methylated441355-441355?
S-adenosyl-L-methionine + tryptamineS-adenosyl-L-homocysteine + alpha-N-methyltryptamine
show the reaction diagram		Rattus norvegicus-two N-methyltransferases, non-specific or specific for tryptamine, 5-methyltetrahydrofolate can replace S-adenosyl-L-methionine as methyl donor441353-441353?
S-adenosyl-L-methionine + tryptamineS-adenosyl-L-homocysteine + alpha-N-methyltryptamine
show the reaction diagram		Rattus norvegicus-S-adenosyl-L-methionine-dependent enzyme441356-441356?
S-adenosyl-L-methionine + tryptamineS-adenosyl-L-homocysteine + alpha-N-methyltryptamine
show the reaction diagram		Rattus norvegicus-i.e. 3-[2-aminoethyl] indole, best substrate, two N-methyltransferases: A and B, non-specific441353-441353?
S-adenosyl-L-methionine + tryptamineS-adenosyl-L-homocysteine + alpha-N-methyltryptamine
show the reaction diagram		Oryctolagus cuniculus-i.e. 3-[2-aminoethyl] indole, best substrate, two N-methyltransferases: A and B, non-specific441352--?
S-adenosyl-L-methionine + tryptamineS-adenosyl-L-homocysteine + alpha-N-methyltryptamine
show the reaction diagram		Oryctolagus cuniculus-i.e. 3-[2-aminoethyl] indole, best substrate, two N-methyltransferases: A and B, non-specific441354-441354?
(R)-isosalsoline + methyl group donorN-methyl-(R)-isosalsoline + demethylated methyl group donor
show the reaction diagram		Bos taurus--441355N-methyl-(R)-isosalsoline is enzymatically formed in liver and can be transported into the brain from blood, it may act as neurotransmitter441355?
additional information?-Oryctolagus cuniculus-two N-methyltransferases A and B with very broad but overlapping substrate specificity for primary and secondary amines, lipophilic substrates, overview poor substrates, no substrates: N-acetylserotonine, 4-aminoacetophenone, 4-aminophenol, benzamide, 4-chloroaniline, deoxyepinephrine, 1,4-diaminobutane, dopamine, 1-ethanol-2-amine, ethylenediamine, histamine, histidine methylester, 3-hydroxytryptamine, indole, pyrrole, methylamine, N-methyldopamine, nicotinamide, octopamine, phenylalanine, phenylethanolamine, theophylline, tryptophan, tyrosine, N,N-dimethyltryptamine441354---

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
(R)-isosalsoline + methyl group donorN-methyl-(R)-isosalsoline + demethylated methyl group donor
show the reaction diagram		Bos taurus--441355N-methyl-(R)-isosalsoline is enzymatically formed in liver and can be transported into the brain from blood, it may act as neurotransmitter441355
S-adenosyl-L-methionine + an amineS-adenosyl-L-homocysteine + an N-methylamine
show the reaction diagram		Oryctolagus cuniculus-enzymes participate in detoxication, recycling of drugs after initial demethylation441354--
S-adenosyl-L-methionine + an amineS-adenosyl-L-homocysteine + an N-methylamine
show the reaction diagram		Rattus norvegicus-xenobiotic biotransforming enzyme, enzyme is leaked easily into the blood stream due to an increased membrane permeability of hepatocytes caused by cholestasis441356--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
S-adenosyl-L-methionineOryctolagus cuniculus--441352, 441354 2D-image
S-adenosyl-L-methionineRattus norvegicus--441353, 441356 2D-image

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
No entries in this field

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
N,N-DimethyltryptamineOryctolagus cuniculus-competitive inhibitor441354 2D-image
additional informationOryctolagus cuniculus-substrate inhibition, but not by tryptamine and 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline441354-

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
additional informationRattus norvegicus-biosynthesis of enzyme is induced in response to obstructive jaundice441356-

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.01-7,8-dichloro-1,2,3,4-tetrahydroisoquinolineOryctolagus cuniculus-transferase A, pH 7.6441354 2D-image
2-7,8-dichloro-1,2,3,4-tetrahydroisoquinolineOryctolagus cuniculus-transferase B, pH 7.6441354 2D-image
7.6-AnilineOryctolagus cuniculus-transferase A, pH 7.6441354 2D-image
7.8-AnilineOryctolagus cuniculus-transferase B, pH 7.6441354 2D-image
6.25-beta-phenylethylamineRattus norvegicus-5-methyltetrahydrofolate as methyl donor441353 2D-image
0.24-desmethylimipramineOryctolagus cuniculus-transferase B, pH 8.5441354 2D-image
0.3-desmethylimipramineOryctolagus cuniculus-transferase A, pH 8.5441354 2D-image
0.2-imidazoleOryctolagus cuniculus-transferase A, pH 8.5441354 2D-image
5.1-imidazoleOryctolagus cuniculus-transferase B, pH 8.5441354 2D-image
1.5-pyrazoleOryctolagus cuniculus-transferase A, pH 7.6441354 2D-image
3.2-pyrazoleOryctolagus cuniculus-transferase B, pH 7.6441354 2D-image
0.015-S-adenosyl-L-methionineOryctolagus cuniculus-1 mM tryptamine as methyl acceptor, pH 8.5441354 2D-image
0.12-tryptamineOryctolagus cuniculus-transferase B, pH 8.5441354 2D-image
0.3-tryptamineOryctolagus cuniculus-transferase A, pH 8.5441354 2D-image
8.3-tryptamineRattus norvegicus-5-methyltetrahydrofolate as methyl donor441353 2D-image
28.3-tryptamineRattus norvegicus-mitochondrial enzyme, cholestatic liver, S-adenosyl-L-methionine441356 2D-image
32.5-tryptamineRattus norvegicus-mitochondrial enzyme, control liver, S-adenosyl-L-methionine441356 2D-image
34.1-tryptamineRattus norvegicus-microsomal enzyme, cholestatic liver, S-adenosyl-L-methionine441356 2D-image
35.6-tryptamineRattus norvegicus-microsomal enzyme, control liver, S-adenosyl-L-methionine441356 2D-image

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.667-7,8-dichloro-1,2,3,4-tetrahydroisoquinolineOryctolagus cuniculus-transferase A, pH 7.6441354 2D-image
3.67-7,8-dichloro-1,2,3,4-tetrahydroisoquinolineOryctolagus cuniculus-transferase B, pH 7.6441354 2D-image
0.0333-AnilineOryctolagus cuniculus-transferase A, pH 7.6441354 2D-image
0.367-AnilineOryctolagus cuniculus-transferase B, pH 7.6441354 2D-image
0.0333-desmethylimipramineOryctolagus cuniculus-transferase B, pH 8.5441354 2D-image
0.233-desmethylimipramineOryctolagus cuniculus-transferase A, pH 8.5441354 2D-image
0.0833-imidazoleOryctolagus cuniculus-transferase A, pH 8.5441354 2D-image
0.167-imidazoleOryctolagus cuniculus-transferase B, pH 8.5441354 2D-image
0.1-pyrazoleOryctolagus cuniculus-transferase B, pH 7.6441354 2D-image
0.25-pyrazoleOryctolagus cuniculus-transferase A, pH 7.6441354 2D-image
0.117-S-adenosyl-L-methionineOryctolagus cuniculus-transferase B, pH 8.5441354 2D-image
0.2-S-adenosyl-L-methionineOryctolagus cuniculus-transferase A, pH 8.5441354 2D-image
0.4-tryptamineOryctolagus cuniculus-transferase A, pH 8.5441354 2D-image
0.45-tryptamineOryctolagus cuniculus-transferase B, pH 8.5441354 2D-image

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.006-N,N-DimethyltryptamineOryctolagus cuniculus-N-methyltransferase B441354 2D-image
0.01-N,N-DimethyltryptamineOryctolagus cuniculus-N-methyltransferase A441354 2D-image

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
3.8e-07-Rattus norvegicus-beta-phenylethylamine + S-adenosyl-L-methionine441353
1.18e-06-Rattus norvegicus-tryptamine + S-adenosyl-L-methionine441353
1.2e-06-Bos taurus-N-methyltransferase A, (-)-(S)-isosalsoline441355
2.1e-06-Bos taurus-N-methyltransferase A, (-)-(S)-salsolidine441355
3.3e-06-Bos taurus-N-methyltransferase A, (+)-(R)-isosalsoline441355
6.5e-05-Rattus norvegicus-beta-phenylethylamine + 5-methyltetrahydrofolate441353
6.8e-05-Oryctolagus cuniculus-N-methyltransferase A, aniline441354
0.000198-Rattus norvegicus-tryptamine + 5-methyltetrahydrofolate441353
0.00022-Oryctolagus cuniculus-N-methyltransferase B, desmethylimipramine441354
0.00026-Oryctolagus cuniculus-N-methyltransferase A, desmethylimipramine441354
0.00044-Oryctolagus cuniculus-N-methyltransferase A, tryptamine441354
0.00127-Oryctolagus cuniculus-N-methyltransferase B, aniline441354
0.0031-Oryctolagus cuniculus-N-methyltransferase B, tryptamine441354
additional information-Rattus norvegicus-specific activities of serum, control and cholestatic liver in cytosolic, mitochondrial and microsomal preparations for 0.5, 1, 2, 3, 7, 14, 28 and 42 days after common bile duct ligation, activities of mitochondrial and microsomal enzyme in cholestatic liver and of serum enzyme increase after common bile duct ligation, Vmax-values441356

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
6.57Rattus norvegicus-5-methyltetrahydrofolate as donor441353
7.9-Rattus norvegicus-S-adenosyl-L-methionine as donor441353
8.5-Oryctolagus cuniculus--441354
additional information-Oryctolagus cuniculus-transferase A: pI 4.9, transferase B: pI 5.1441354

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
7.28.9Oryctolagus cuniculus-tryptamine, about half-maximal activity at pH 7.2 and 8.9, transferase A441354
7.58.8Oryctolagus cuniculus-tryptamine, about half-maximal activity at pH 7.5 and 90% at pH 8.8, transferase B441354

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
37-Rattus norvegicus-assay at441353
37-Oryctolagus cuniculus-assay at441354
37-Bos taurus-assay at441355
37-Rattus norvegicus-assay at441356

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
brainRattus norvegicus--441353, 441356Manually annotated by BRENDA team
heartRattus norvegicus--441356Manually annotated by BRENDA team
liverOryctolagus cuniculus-two amine N-methyltransferases, A and B441352, 441354Manually annotated by BRENDA team
liverBos taurus--441355Manually annotated by BRENDA team
liverRattus norvegicus-investigation of enzyme in cholestatic liver, induced by common bile duct ligation for a period of 42 days441356Manually annotated by BRENDA team
lungOryctolagus cuniculus--441352Manually annotated by BRENDA team
lungRattus norvegicus--441356Manually annotated by BRENDA team
salivary glandRattus norvegicus--441356Manually annotated by BRENDA team
serumRattus norvegicus-investigation of enzyme in serum, after common bile duct ligation for a period of 42 days441356Manually annotated by BRENDA team
small intestineRattus norvegicus--441356Manually annotated by BRENDA team
stomachRattus norvegicus--441356Manually annotated by BRENDA team

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
cytosolRattus norvegicus-liver5829441356Manually annotated by BRENDA team
membraneRattus norvegicus-hepatic membrane-bound enzyme16020441356Manually annotated by BRENDA team
microsomeRattus norvegicus-liver-441356Manually annotated by BRENDA team
mitochondrionRattus norvegicus-liver5739441356Manually annotated by BRENDA team

PDBSCOPCATHORGANISM
2a14, downloadSCOP (2a14)CATH (2a14)Homo sapiens

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
30000-Oryctolagus cuniculus-gel filtration441354
additional information-Oryctolagus cuniculus-amino acid composition of transferase A441354

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
monomerOryctolagus cuniculus-1 * 30000, SDS-PAGE441354
additional informationOryctolagus cuniculus-aggregation upon denaturation leads to 60 kDa and 90 kDa fractions441354

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
6.2-Oryctolagus cuniculus-optimal for transferase A441354
7.8-Oryctolagus cuniculus-optimal for transferase B441354

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
No entries in this field

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-80°C, partially purified, per month, less than 10% loss of activityOryctolagus cuniculus-441354
-80°C, purified, per month, about 25% loss of activityOryctolagus cuniculus-441354
2°C, per week, 25% loss of activityOryctolagus cuniculus-441354

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
amine N-methyltransferase ABos taurus-441355
two N-methyltransferases A and B separable by ammonium sulfate fractionation, HPLC-ion exchange chromatographyOryctolagus cuniculus-441354
partialRattus norvegicus-441353

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISMLINK TO PUBMEDSOURCE
441352Crooks, P.A.; Godin, C.S.; Nwosu, C.G.; Ansher, S.S.; Jakoby, W.B.Reevaluation of the products of tryptamine catalyzed by rabbit liver N-methyltransferasesBiochem. Pharmacol.351600-16031986Oryctolagus cuniculus PubMed
441353Hsu, L.L.; Mandell, A.J.Multiple N-methyltransferases for aromatic alkylamines in brainLife Sci.13847-8581973Rattus norvegicus PubMed
441354Ansher, S.S.; Jakoby, W.B.Amine N-methyltransferases from rabbit liverJ. Biol. Chem.2613996-40011986Oryctolagus cuniculus PubMed
441355Bahnmaier, A.H.; Woesle, B.; Thomas, H.Stereospecific N-methylation of the tetrahydroisoquinoline alkaloids isosalsoline and salsolidine by amine N-methyltransferase A from bovine liverChirality11160-1651999Bos taurus PubMed
441356Kim, Y.H.; Joo, I.Arylamine N-methyltransferase and thiol methyltransferase activities in cholestatic rat liver induced by common bile duct ligationExp. Mol. Med.3323-282001Rattus norvegicus PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 2.1.1.49)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)