Information on EC 1.8.2.2 -

Information on EC 1.8.2.2 - thiosulfate dehydrogenase:

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EC NUMBER	COMMENTARY
1.8.2.2	-

RECOMMENDED NAME	GeneOntology No.
thiosulfate dehydrogenase	GO:0050338

REACTION	REACTION DIAGRAM	COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c		-	-	-	-

REACTION TYPE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
oxidation	-	-	-	-
oxidation	halophilic bacterium	-	-	673503
oxidation	Allochromatium vinosum	-	-	676077
redox reaction	-	-	-	-
reduction	-	-	-	-

PATHWAY	KEGG Link	MetaCyc Link
thiosulfate oxidation I (to tetrathionate)	-	THIOSULFOX-PWY

SYSTEMATIC NAME	IUBMB Comments
thiosulfate:ferricytochrome-c oxidoreductase	-

SYNONYMS	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
enzymes, thiosulfate-oxidizing	-	-	-	-
oxidase, thiosulfate	-	-	-	-
tetrathionate synthase	-	-	-	-
tetrathionate synthase	halophilic bacterium	-	-	673503
thiosulfate dehydrogenase	halophilic bacterium	-	-	673503
thiosulfate dehydrogenase	Allochromatium vinosum	-	-	676077
thiosulfate oxidase	-	-	-	-
thiosulfate-acceptor oxidoreductase	-	-	-	-
thiosulfate-oxidizing enzyme	-	-	-	-

CAS REGISTRY NUMBER	COMMENTARY
9076-88-4	-

ORGANISM	COMMENTARY	LITERATURE	SEQUENCE CODE	SEQUENCE DB	SOURCE
Acidiphilium acidophilum	-	394126, 394127	-	-
Acidithiobacillus ferrooxidans	-	394120, 394125, 659545, 689730	-	-
Acidithiobacillus thiooxidans	JCM7814	394129	-	-
Alcaligenes sp.	-	394123	-	-
Allochromatium vinosum	-	394117, 676077	-	-
halophilic bacterium	extremely halophilic, neutrophilic archaeon	673503	-	-
Halothiobacillus neapolitanus	-	394127	-	-
heterotrophic bacterium	two bacteria designated A-50 and C-3, isolated from percolation units containing garden soil and elemental sulfur, the enzyme system in C-3 is constitutive, but in A-50 it is induced by thiosulfate or tetrathionate	394119	-	-
Hyphomicrobium sp. X	X	394121	-	-
Pseudomonas aeruginosa	-	394116	-	-
Pseudomonas sp.	16B, marine heterotroph	394122	-	-
Pseudomonas sp. W5	W5	394128	-	-
Rhodopila globiformis	-	394115	-	-
Rhodotorula sp.	-	394078	-	-
Tetrathiobacter kashmirensis	-	690014	-	-
Thermithiobacillus tepidarius	-	288769, 394118, 394127	-	-
Thiobacillus sp.	W5	394128	-	-
Thiobacillus sp.	X	394121	-	-
Thiobacillus thioparus	-	394120, 394124	-	-

GENERAL INFORMATION	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

SUBSTRATE	PRODUCT	REACTION DIAGRAM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY/ Substrate	LITERATURE/ Substrate	COMMENTARY/ Product	LITERATURE/ Product	Reversibility r=reversible ir=irreversible ?=not specified
thiosulfate + cytochrome c	tetrathionate + reduced cytochrome c		Acidithiobacillus ferrooxidans, Thiobacillus thioparus	-	-	394120	-	394120	?
thiosulfate + cytochrome c	tetrathionate + reduced cytochrome c		Thermithiobacillus tepidarius	-	-	288769	-	288769	?
thiosulfate + ferricyanide	tetrathionate + ferrocyanide		Acidithiobacillus ferrooxidans	-	-	659545	-	-	?
thiosulfate + ferricyanide	tetrathionate + ferrocyanide		Pseudomonas aeruginosa	-	-	394116	-	-	-
thiosulfate + ferricyanide	tetrathionate + ferrocyanide		Allochromatium vinosum	-	-	394117	-	-	-
thiosulfate + ferricyanide	tetrathionate + ferrocyanide		Rhodotorula sp.	-	-	394078	-	-	-
thiosulfate + ferricyanide	tetrathionate + ferrocyanide		Rhodopila globiformis	-	-	394115	-	-	-
thiosulfate + ferricyanide	tetrathionate + ferrocyanide		Tetrathiobacter kashmirensis	-	-	690014	-	-	?
thiosulfate + ferricyanide	tetrathionate + ferrocyanide		Allochromatium vinosum	-	activity assay	676077	-	-	ir
thiosulfate + ferricytochrome c	tetrathionate + ferrocytochrome c		Allochromatium vinosum	-	-	676077	-	-	?
thiosulfate + ferricytochrome c	tetrathionate + ferrocytochrome c		halophilic bacterium	-	-	673503	-	-	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus sp.	-	strictly specific for thiosulfate	394128	-	394128	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Alcaligenes sp.	-	strictly specific for thiosulfate	394123	-	394123	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus thioparus	-	cytochrome c of yeast is a poor electron acceptor	394124	-	394124	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Allochromatium vinosum	-	the enzyme rapidly reduces high-potential nonheme iron protein in the presence of thiosulfate	394117	-	394117	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		heterotrophic bacterium	-	A-50: once induced to oxidize thiosulfate, also reduces tetrathionate to thiosulfate in the presence of an electron donor such as lactate, the possibility cannot be excluded, that a separate tetrathionate-reducing enzyme is induced	394119	-	394119	r
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Pseudomonas sp.	-	only native cytochrome c acts as electron acceptor	394122	-	394122	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus thioparus	-	horse cytochrome c is a poor electron acceptor	394124	-	394124	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Allochromatium vinosum	-	horse cytochrome c is a poor electron acceptor	394117	-	394117	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Pseudomonas aeruginosa	-	ferricyanide or native cytochrome c act as electron acceptors	394116	-	394116	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Pseudomonas sp.	-	ferricyanide or native cytochrome c act as electron acceptors	394122	-	394122	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Alcaligenes sp.	-	ferricyanide or native cytochrome c act as electron acceptors	394123	-	394123	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus thioparus	-	ferricyanide or native cytochrome c act as electron acceptors	394120	-	394120	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Rhodotorula sp.	-	ferricyanide or native cytochrome c act as electron acceptors	394078	-	394078	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thermithiobacillus tepidarius	-	ferricyanide or native cytochrome c act as electron acceptors	288769	-	288769	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Rhodopila globiformis	-	ferricyanide or native cytochrome c act as electron acceptors	394115	-	394115	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		heterotrophic bacterium	-	ferricyanide or native cytochrome c act as electron acceptors	394119	-	394119	r
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Pseudomonas aeruginosa	-	cytochrome c acts as electron acceptor	394116	-	394116	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Pseudomonas sp.	-	cytochrome c acts as electron acceptor	394122	-	394122	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus sp.	-	cytochrome c acts as electron acceptor	394121	-	394121	ir
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Alcaligenes sp.	-	cytochrome c acts as electron acceptor	394123	-	394123	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus thioparus	-	cytochrome c acts as electron acceptor	394124	-	394124	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Allochromatium vinosum	-	cytochrome c acts as electron acceptor	394117	-	394117	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Rhodotorula sp.	-	cytochrome c acts as electron acceptor	394078	-	394078	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thermithiobacillus tepidarius	-	cytochrome c acts as electron acceptor	288769	-	288769	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thermithiobacillus tepidarius	-	cytochrome c acts as electron acceptor	394118	-	394118	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Rhodopila globiformis	-	cytochrome c acts as electron acceptor	394115	-	394115	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		heterotrophic bacterium	-	cytochrome c acts as electron acceptor	394119	-	394119	r
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus thioparus	-	ferricyanide is a much better electron acceptor than cytochrome c	394124	-	394124	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus sp.	-	cytochrome 557 becames reduced when mixed with thiosulfate, enzyme and a trace of cytochrome 553.5, the omission of either the enzyme or cytochrome 553.5 prevents this reduction	394121	-	394121	ir
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Acidiphilium acidophilum	-	phenazine methosulfate and phenazine ethosulfate assayed in the presence of dichlorophenolindophenol and Thialhalivibrio versutus cytochrome c550 support low, but significant enzyme activities	394126	-	394126	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Allochromatium vinosum	-	cytochrome c of yeast and cytochrome c of tuna act as electron acceptors	394117	-	394117	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Pseudomonas aeruginosa	-	mammalian cytochrome c acts as electron acceptor	394116	-	394116	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus sp.	-	mammalian cytochrome c acts as electron acceptor	394121	-	394121	ir
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus thioparus	-	mammalian cytochrome c acts as electron acceptor	394120	-	394120	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Allochromatium vinosum	-	mammalian cytochrome c acts as electron acceptor	394117	-	394117	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Acidiphilium acidophilum	-	mammalian cytochrome c acts as electron acceptor	394126	-	394126	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		heterotrophic bacterium	-	mammalian cytochrome c acts as electron acceptor	394119	-	394119	r
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Acidiphilium acidophilum	-	Wurster's blue can also serve as electron acceptor	394126	-	394126	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus sp.	-	cytochrome c553.5 acts as electron acceptor	394121	-	394121	ir
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Acidithiobacillus ferrooxidans	-	the activity does not couple with mammalian cytochrome c as electron acceptor	394125	-	394125	ir
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Pseudomonas sp.	-	the activity does not couple with mammalian cytochrome c as electron acceptor	394122	-	394122	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus sp.	-	the activity does not couple with mammalian cytochrome c as electron acceptor	394128	-	394128	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Rhodotorula sp.	-	the activity does not couple with mammalian cytochrome c as electron acceptor	394078	-	394078	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Acidithiobacillus thiooxidans	-	the activity does not couple with mammalian cytochrome c as electron acceptor	394129	-	394129	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Rhodopila globiformis	-	the activity does not couple with mammalian cytochrome c as electron acceptor	394115	-	394115	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Allochromatium vinosum	-	ferricyanide is a good electron acceptor	394117	-	394117	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Acidiphilium acidophilum	-	ferricyanide is a good electron acceptor	394126	-	394126	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Acidithiobacillus ferrooxidans	-	ferricyanide acts as electron acceptor	394120	-	394120	-
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Acidithiobacillus ferrooxidans	-	ferricyanide acts as electron acceptor	394125	-	394125	ir
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Pseudomonas aeruginosa	-	ferricyanide acts as electron acceptor	394116	-	394116	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Pseudomonas sp.	-	ferricyanide acts as electron acceptor	394122	-	394122	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus sp.	-	ferricyanide acts as electron acceptor	394128	-	394128	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus sp.	-	ferricyanide acts as electron acceptor	394121	-	394121	ir
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Alcaligenes sp.	-	ferricyanide acts as electron acceptor	394123	-	394123	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus thioparus	-	ferricyanide acts as electron acceptor	394120	-	394120	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thiobacillus thioparus	-	ferricyanide acts as electron acceptor	394124	-	394124	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Allochromatium vinosum	-	ferricyanide acts as electron acceptor	394117	-	394117	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Rhodotorula sp.	-	ferricyanide acts as electron acceptor	394078	-	394078	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Acidithiobacillus thiooxidans	-	ferricyanide acts as electron acceptor	394129	-	394129	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Acidiphilium acidophilum	-	ferricyanide acts as electron acceptor	394126	-	394126	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Thermithiobacillus tepidarius	-	ferricyanide acts as electron acceptor	288769	-	288769	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Rhodopila globiformis	-	ferricyanide acts as electron acceptor	394115	-	394115	?
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		heterotrophic bacterium	-	ferricyanide acts as electron acceptor	394119	-	394119	r
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Acidithiobacillus ferrooxidans	-	the enzyme is active only with ferricyanide, not with native or mammalian cytochrome c	394120	-	394120	-
thiosulfate + oxidized acceptor	tetrathionate + reduced acceptor		Acidithiobacillus ferrooxidans	-	the enzyme is active only with ferricyanide, not with native or mammalian cytochrome c	394125	-	394125	ir
additional information	?	-	Acidiphilium acidophilum	-	no activity with: pyrrolo-quinoline quinone, methyl- or benzyl viologen, methylthiazol tetrazolium bromide	394126	-	-	-
additional information	?	-	Allochromatium vinosum	-	no activity with: cytochrome c-552, cytochrome c', cytochrome c-553	394117	-	-	-
additional information	?	-	Thiobacillus sp.	-	no activity with: benzyl viologen, 2,6-dichloroindophenol, 2,6-dichloroindophenol with phenazine methosulfate, 2,6-dichloroindophenol with phenazine ethosulfate, horse heart cytochrome c with phenazine methosulfate, horse heart cytochrome c with phenazine ethosulfate, NAD+, methylene blue, 2,6-dichlorophenol indophenol	394128	-	-	-
additional information	?	-	Alcaligenes sp.	-	NAD+, methylene blue, 2,6-dichlorophenol indophenol	394123	-	-	-
additional information	?	-	Thiobacillus thioparus	-	NAD+, methylene blue, 2,6-dichlorophenol indophenol	394124	-	-	-
additional information	?	-	Acidiphilium acidophilum	-	NAD+, methylene blue, 2,6-dichlorophenol indophenol	394126	-	-	-
additional information	?	-	Thiobacillus thioparus	-	no activity with: NADP+, O2	394124	-	-	-
additional information	?	-	Acidiphilium acidophilum	-	no activity with: NADP+, O2	394126	-	-	-
additional information	?	-	Alcaligenes sp.	-	no activity with FAD	394123	-	-	-

NATURAL SUBSTRATES	NATURAL PRODUCTS	REACTION DIAGRAM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY SUBSTRATE	LITERATURE (Substrate)	COMMENTARY PRODUCT	LITERATURE (Product)
thiosulfate + cytochrome c	tetrathionate + reduced cytochrome c		Acidithiobacillus ferrooxidans, Thiobacillus thioparus	-	-	394120	-	394120
thiosulfate + cytochrome c	tetrathionate + reduced cytochrome c		Thermithiobacillus tepidarius	-	-	288769	-	288769
thiosulfate + ferricytochrome c	tetrathionate + ferrocytochrome c		Allochromatium vinosum	-	-	676077	-	-
thiosulfate + ferricytochrome c	tetrathionate + ferrocytochrome c		halophilic bacterium	-	-	673503	-	-

COFACTOR	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
cytochrome c	Allochromatium vinosum	-	-	676077	2D-image
Ferricytochrome	halophilic bacterium	-	-	673503	2D-image
Heme c	Acidiphilium acidophilum	-	5.3 mole per mol of native enzyme, made up of two different c-553 hemes, present in both subunit types	394126, 394127	2D-image
Heme c	Thiobacillus sp.	-	4 mol per mol of enzyme, present in both subunit types	394128	2D-image
Heme c	Acidithiobacillus thiooxidans	-	-	394129	2D-image

METALS and IONS	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
Iron	Thiobacillus thioparus	-	enzyme contains 2 mol of non-heme iron	394124

INHIBITORS	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
2,2'-Bipyridyl	Rhodotorula sp.	-	not inhibitory at 5 mM	394078	2D-image
2,2'-Bipyridyl	heterotrophic bacterium	-	not inhibitory	394119	2D-image
2,2'-Bipyridyl	Thiobacillus thioparus	-	50% inhibition at 1 mM, a 60 min incubation period is necessary to potentiate the inhibition	394124	2D-image
azide	heterotrophic bacterium	-	strongly inhibits thiosulfate oxidation by A-50 extracts	394119	2D-image
azide	Thiobacillus sp.	-	not inhibitory at 10 mM	394121	2D-image
azide	Acidithiobacillus ferrooxidans	-	60% inhibition at 10 mM	394125	2D-image
azide	Acidiphilium acidophilum	-	63% inhibition at 0.5 mM	394126	2D-image
Cupferron	heterotrophic bacterium	-	strongly inhibits thiosulfate oxidation by A-50 extracts	394119	2D-image
cyanide	Allochromatium vinosum	-	50% inhibition at 1.3 mM	394117	2D-image
cyanide	heterotrophic bacterium	-	strongly inhibits thiosulfate oxidation by A-50 extracts	394119	2D-image
cyanide	Acidithiobacillus ferrooxidans	-	28.9% inhibition at 10 mM	394125	2D-image
cyanide	Thiobacillus sp.	-	not inhibitory	394128	2D-image
deoxycholate	Rhodotorula sp.	-	-	394078	2D-image
Diethyldicarbonate	Acidithiobacillus ferrooxidans	-	-	689730	2D-image
diethyldithiocarbamate	heterotrophic bacterium	-	slightly inhibits	394119	2D-image
dithionate	Pseudomonas aeruginosa	-	18% inhibition at 1 mM, 15% inhibition at 0.1 mM and 0.01 mM	394116	2D-image
EDTA	Pseudomonas aeruginosa	-	13% inhibition at 1 mM, 3% inhibition at 0.1 mM	394116	2D-image
EDTA	Alcaligenes sp.	-	18% inhibition at 1 mM and 46% inhibition at 20 mM	394123	2D-image
EDTA	Thiobacillus thioparus	-	44% inhibition at 10 mM, a 15 min incubation period is necessary to potentiate the inhibition	394124	2D-image
EDTA	Acidiphilium acidophilum	-	not inhibitory	394126	2D-image
EDTA	Thiobacillus sp.	-	not inhibitory	394128	2D-image
HgCl2	Rhodotorula sp.	-	100% inhibition at 0.5 mM, 45% inhibition at 0.25 mM and 15% inhibition at 0.1 mM	394078	2D-image
HgCl2	Pseudomonas aeruginosa	-	37% inhibition at 0.1 mM, 13% inhibition at 0.01 mM	394116	2D-image
HgCl2	Alcaligenes sp.	-	100% inhibition at 1 mM	394123	2D-image
HgCl2	Thiobacillus thioparus	-	100% inhibition at 0.5 mM	394124	2D-image
N-ethylmaleimide	Rhodotorula sp.	-	12% inhibition at 1 mM	394078	2D-image
N-ethylmaleimide	Pseudomonas aeruginosa	-	40% inhibition at 1 mM, 15% inhibition at 0.1 mM	394116	2D-image
N-ethylmaleimide	heterotrophic bacterium	-	not inhibitory	394119	2D-image
N-ethylmaleimide	Alcaligenes sp.	-	78% inhibition at 1 mM	394123	2D-image
N-ethylmaleimide	Thiobacillus thioparus	-	100% inhibition at 1 mM, a 15 min incubation period is necessary to potentiate the inhibition	394124	2D-image
N-ethylmaleimide	Acidiphilium acidophilum	-	not inhibitory	394126	2D-image
N-ethylmaleimide	Thiobacillus sp.	-	not inhibitory	394128	2D-image
Na2SeO3	Acidiphilium acidophilum	-	39% inhibition at 0.5 mM	394126	2D-image
Na2SeO3	Thiobacillus sp.	-	it inhibits the oxidation of thiosulfate by whole cells	394128	2D-image
Na2SeO4	Acidiphilium acidophilum	-	51% inhibition at 5 mM	394126	2D-image
o-Phenantroline	Rhodotorula sp.	-	17% inhibition at 5 mM	394078	2D-image
p-chloromercuribenzoate	Pseudomonas aeruginosa	-	47% inhibition at 1 mM, 7% inhibition at 0.1 mM	394116	2D-image
p-chloromercuribenzoate	heterotrophic bacterium	-	not inhibitory	394119	2D-image
p-chloromercuribenzoate	Alcaligenes sp.	-	90% inhibition at 1 mM	394123	2D-image
p-chloromercuribenzoate	Thiobacillus thioparus	-	72.8% inhibition at 1 mM	394124	2D-image
p-chloromercuribenzoate	Acidiphilium acidophilum	-	32% inhibition at 0.1 mM	394126	2D-image
p-hydroxymercuribenzoate	Rhodotorula sp.	-	50% inhibition at 1 mM, 40% inhibition at 0.5 mM and 10% inhibition at 0.1 mM	394078	2D-image
SO32-	Rhodotorula sp.	-	-	394078	2D-image
SO32-	Pseudomonas aeruginosa	-	75% inhibition at 1 mM, 48% inhibition at 0.1 mM 33% inhibition at 0.01 mM	394116	2D-image
SO32-	Allochromatium vinosum	-	50% inhibition at 1.7 mM	394117	2D-image
SO32-	heterotrophic bacterium	-	-	394119	2D-image
SO32-	Acidithiobacillus ferrooxidans	-	-	394120	2D-image
SO32-	Thiobacillus thioparus	-	strongly inhibits, the inhibition is time-dependent and irreversible, 50% inhibition at 0.005 mM in 5 min	394120	2D-image
SO32-	Alcaligenes sp.	-	62% inhibition at 3 mM	394123	2D-image
SO32-	Thiobacillus thioparus	-	50% inhibition at 0.005 mM , time-dependent inhibition, irreversible	394124	2D-image
SO32-	Acidiphilium acidophilum	-	100% inhibition at 0.5 mM	394126	2D-image
SO32-	Thiobacillus sp.	-	inhibits at concentrations above 0.05 mM, the sulfite inhibition of thiosulfate oxidation by whole cells is very similar to the inhibition pattern of the enzyme	394128	2D-image
SO42-	Pseudomonas aeruginosa	-	33% inhibition at 1 mM, 15% inhibition at 0.1 mM, 7% inhibition at 0.01 mM	394116	2D-image
Sulphite	Allochromatium vinosum	-	-	676077	2D-image
Thiocyanate	Thermithiobacillus tepidarius	-	slightly inhibits	394118	2D-image
HgCl2	Acidithiobacillus ferrooxidans	-	73.3% inhibition at 1 mM	394125	2D-image
additional information	Acidithiobacillus ferrooxidans	-	reagents selective for arginine, cysteine and tryptophane have no effect on enzyme activity	689730	-

ACTIVATING COMPOUND	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
Cl-	halophilic bacterium	-	-	673503	2D-image

KM VALUE [mM]	KM VALUE [mM] Maximum	SUBSTRATE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
0.34	-	ferricyanide	Rhodotorula sp.	-	-	394078	2D-image
0.9	-	ferricyanide	Rhodopila globiformis	-	-	394115	2D-image
1.1	-	ferricyanide	Pseudomonas aeruginosa	-	-	394116	2D-image
3.3	-	ferricyanide	Allochromatium vinosum	-	-	394117	2D-image
0.004	-	thiosulfate	Thermithiobacillus tepidarius	-	with cytochrome c as electron acceptor	288769	2D-image
0.005	-	thiosulfate	Thiobacillus thioparus	-	cytochrome c as electron acceptor	394124	2D-image
0.1	-	thiosulfate	Thiobacillus thioparus	-	ferricyanide as electron acceptor	394124	2D-image
0.11	-	thiosulfate	Thermithiobacillus tepidarius	-	with ferricyanide as electron acceptor	288769	2D-image
0.12	-	thiosulfate	Thiobacillus sp.	-	at pH 7.5	394128	2D-image
0.14	-	thiosulfate	Rhodotorula sp.	-	with native cytochrome c as electron acceptor	394078	2D-image
0.16	-	thiosulfate	Rhodotorula sp.	-	with ferricyanide as electron acceptor	394078	2D-image
0.54	-	thiosulfate	Acidiphilium acidophilum	-	at pH 7	394126	2D-image
0.62	-	thiosulfate	Rhodopila globiformis	-	-	394115	2D-image
0.67	-	thiosulfate	Pseudomonas aeruginosa	-	-	394116	2D-image
0.81	-	thiosulfate	Acidithiobacillus thiooxidans	-	-	394129	2D-image
0.9	-	thiosulfate	Acidithiobacillus ferrooxidans	-	-	394125	2D-image
1.57	-	thiosulfate	Pseudomonas sp.	-	pH 6.1-6.3, 30�C	394122	2D-image
0.13	-	high-potential non-heme iron protein	Allochromatium vinosum	-	-	394117	-
additional information	-	additional information	Pseudomonas aeruginosa	-	-	394116	-
additional information	-	additional information	Allochromatium vinosum	-	-	394117	-
additional information	-	additional information	Thermithiobacillus tepidarius	-	-	394118	-
additional information	-	additional information	heterotrophic bacterium	-	-	394119	-
additional information	-	additional information	Pseudomonas sp.	-	temperature dependency of Km	394122	-
additional information	-	additional information	Thiobacillus thioparus	-	-	394124	-
additional information	-	additional information	Acidithiobacillus ferrooxidans	-	-	394125	-

TURNOVER NUMBER [1/s]	TURNOVER NUMBER MAXIMUM[1/s]	SUBSTRATE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
17000	-	ferricyanide	Allochromatium vinosum	-	-	676077	2D-image
2300	-	thiosulfate	Thiobacillus sp.	-	-	394128	2D-image
8500	-	thiosulfate	Acidiphilium acidophilum	-	at pH 7	394126	2D-image
11000	-	thiosulfate	Allochromatium vinosum	-	-	676077	2D-image
250000	-	thiosulfate	Acidiphilium acidophilum	-	at least, at pH 3	394126	2D-image

kcat/KM VALUE [1/mMs^-1]	kcat/KM VALUE [1/mMs^-1] Maximum	SUBSTRATE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
No entries in this field

Ki VALUE [mM]	Ki VALUE [mM] Maximum	INHIBITOR	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
0.03	-	Na2SeO3	Thiobacillus sp.	-	it is possible that selenite blocks access to the thiosulfate dehydrogenase or has an inhibiting effect on the respiratory chain itself	394128	2D-image
0.3	-	SO32-	Thiobacillus sp.	-	sulfite resembles the sulfonate part of thiosulfate and might, therefore, block the active site of the enzyme	394128	2D-image

IC50 VALUE [mM]	IC50 VALUE [mM] Maximum	INHIBITOR	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg]	SPECIFIC ACTIVITY MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
0.06	-	Acidithiobacillus thiooxidans	-	-	394129
1	-	Thermithiobacillus tepidarius	-	cytoplasm	288769
2	-	Thermithiobacillus tepidarius	-	membrane	288769
9.13	-	Rhodopila globiformis	-	partially purified enzyme	394115
9.6	-	Thermithiobacillus tepidarius	-	periplasm	288769
11.38	-	Pseudomonas sp.	-	purified enzyme	394122
146.1	-	Thiobacillus thioparus	-	-	394124
316	-	Thermithiobacillus tepidarius	-	partially purified enzyme	288769
1149	-	Thiobacillus sp.	-	purified enzyme	394128
4925	-	Acidiphilium acidophilum	-	purified enzyme	394126
6010	-	Alcaligenes sp.	-	-	394123
additional information	-	Thiobacillus sp.	-	-	394121
additional information	-	Alcaligenes sp.	-	specific activities in crude cell-free extracts of mercaptosuccinate-grown Alcaligenes under a variety of nutritional conditions	394123
additional information	-	Acidithiobacillus ferrooxidans	-	-	394125

pH OPTIMUM	pH MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
3	-	Acidiphilium acidophilum	-	purified enzyme	394126
3	-	Acidithiobacillus ferrooxidans	-	-	689730
3.5	-	Acidithiobacillus thiooxidans	-	-	394129
4	6	Rhodopila globiformis	-	-	394115
4.25	-	Allochromatium vinosum	-	activity assay	676077
4.5	-	Halothiobacillus neapolitanus, Thermithiobacillus tepidarius	-	-	394127
5	-	Thiobacillus sp.	-	the rate of reduction of cytochrome 553.5 at pH 5 is about 10% of the rate at pH 7	394121
5	-	Alcaligenes sp.	-	below, using ferricyanide as electron acceptor	394123
5	-	Thiobacillus thioparus	-	below, using ferricyanide as electron acceptor	394124
5	-	Acidithiobacillus ferrooxidans	-	-	394125
5.2	-	heterotrophic bacterium	-	thiosulfate + ferricyanide	394119
5.5	6.5	Pseudomonas aeruginosa	-	-	394116
5.5	-	Thiobacillus sp.	-	-	394128
6.5	-	Thiobacillus thioparus	-	broad, with cytochrome c as electron acceptor	394124
7	-	Thiobacillus sp.	-	for the reduction of cytochrome 553.5	394121
7.2	7.6	Alcaligenes sp.	-	cytochrome c as electron acceptor	394123
7.8	-	Rhodotorula sp.	-	-	394078
additional information	-	Pseudomonas sp.	-	no definite pH-optimum	394122

pH RANGE	pH RANGE MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
4.5	9	Pseudomonas aeruginosa	-	-	394116
5	9	Alcaligenes sp.	-	-	394123
5.5	8.8	Thiobacillus thioparus	-	little change in activity between	394124

TEMPERATURE OPTIMUM	TEMPERATURE OPTIMUM MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
25	-	Allochromatium vinosum	-	activity assay	676077
30	42	Pseudomonas aeruginosa	-	-	394116
30	-	Rhodotorula sp.	-	-	394078
30	-	Pseudomonas sp.	-	-	394122
35	-	Acidithiobacillus thiooxidans	-	-	394129
40	-	Alcaligenes sp.	-	-	394123

TEMPERATURE RANGE	TEMPERATURE MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
22	48	Alcaligenes sp.	-	about 50% of activity maximum at 22�C and 48�C	394123

pI VALUE	pI VALUE MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
4.2	-	Allochromatium vinosum	-	determined by chromatofocussing	676077
8.3	-	Acidithiobacillus ferrooxidans	-	-	689730

SOURCE TISSUE	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE	SOURCE
No entries in this field

LOCALIZATION	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	GeneOntology No.	LITERATURE	SOURCE
cytoplasm	Tetrathiobacter kashmirensis	-	-	5737	690014
membrane	halophilic bacterium	-	-	16020	673503
periplasm	Thermithiobacillus tepidarius	-	at least 73% of the enzyme activity is recovered in the periplasmic fraction	-	288769
periplasm	Thermithiobacillus tepidarius	-	-	-	394118, 394127
periplasm	Thiobacillus sp.	-	at least 73% of the enzyme activity is recovered in the periplasmic fraction	-	394128
periplasm	Acidithiobacillus thiooxidans	-	-	-	394129
periplasm	Allochromatium vinosum	-	-	-	676077
periplasm	Tetrathiobacter kashmirensis	-	major portion of the total thiosulfate dehydrogenase activity is localized in the periplasmic fraction	-	690014

PDB	SCOP	CATH	ORGANISM
No entries in this field

MOLECULAR WEIGHT	MOLECULAR WEIGHT MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
27000	-	Acidithiobacillus thiooxidans	-	gel filtration	394129
30000	-	Allochromatium vinosum	-	determined by gel filtration	676077
90000	-	Alcaligenes sp.	-	gel filtration	394123
102000	-	Acidiphilium acidophilum	-	gel filtration	394126
102000	-	Acidiphilium acidophilum	-	-	394127
115000	-	Thiobacillus thioparus	-	sucrose density gradient method	394124
120000	-	Thiobacillus sp.	-	gel filtration	394128
138000	-	Thermithiobacillus tepidarius	-	gel filtration	288769
138000	-	Thermithiobacillus tepidarius	-	-	394127
180000	-	Rhodopila globiformis	-	gel filtration	394115

SUBUNITS	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
heterotetramer	Acidiphilium acidophilum	-	2 * 24000 + 2 * 20000, SDS-PAGE, both subunits contain c553-type heme	394126, 394127
heterotetramer	Thiobacillus sp.	-	2 * 33000 + 2 * 27000, SDS-PAGE	394128
monomer	Acidithiobacillus thiooxidans	-	1 * 27900, SDS-PAGE	394129
monomer	Allochromatium vinosum	-	-	676077
tetramer	Acidithiobacillus ferrooxidans	-	4 * 45000, SDS-PAGE	689730
trimer	Thermithiobacillus tepidarius	-	3 * 45000, SDS-PAGE	288769, 394127

POSTTRANSLATIONAL MODIFICATION	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

Crystallization/COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
No entries in this field

pH STABILITY	pH STABILITY MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
2	-	Acidiphilium acidophilum	-	unstable below	394126
4	-	Acidithiobacillus ferrooxidans	-	unstable below	394125
5	7	Acidithiobacillus thiooxidans	-	-	394129

TEMPERATURE STABILITY	TEMPERATURE STABILITY MAXIMUM	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
0	-	Acidiphilium acidophilum	-	20% decrease of activity in 2 h and 60% decrease of activity in 7 h	394126
4	-	Thiobacillus thioparus	-	6 h, 10% loss of activity, 50% loss of activity after 5 days	394124
25	-	Alcaligenes sp.	-	30 min, 7% loss of activity	394123
30	-	Acidiphilium acidophilum	-	50% decrease of activity in 2 h	394126
45	-	Thiobacillus sp.	-	3 min, pH 7, complete loss of activity	394121
45	-	Alcaligenes sp.	-	30 min, complete loss of activity	394123
45	-	Acidithiobacillus thiooxidans	-	stable up to	394129
55	-	Rhodotorula sp.	-	30% decrease of activity after 5 min	394078
55	-	Thiobacillus thioparus	-	5 min, stable	394124
60	-	Rhodotorula sp.	-	50% decrease of activity after 7 min	394078
60	-	heterotrophic bacterium	-	10 min, complete loss of activity, crude extract	394119
60	-	Thiobacillus sp.	-	enzyme activity completely destroyed after 3 min at pH 7	394121
60	-	Thiobacillus thioparus	-	5 min, 50% loss of activity	394124
100	-	Rhodotorula sp.	-	after 2 min the activity is completely destroyed	394078
100	-	Allochromatium vinosum	-	1 min, complete loss of activity	394117
100	-	Pseudomonas sp.	-	after 1 min the activity is completely destroyed	394122
100	-	Thiobacillus thioparus	-	1 min, complete loss of activity	394124
100	-	Acidithiobacillus ferrooxidans	-	complete loss of activity	394125

GENERAL STABILITY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
lability of enzyme during purification and storage at -20�C	Thermithiobacillus tepidarius	-	288769

ORGANIC SOLVENT	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

OXIDATION STABILITY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
No entries in this field

STORAGE STABILITY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
frozen, stable for at least 3 months	Acidiphilium acidophilum	-	394126
-20�C, little loss of activity after 2 months	Acidithiobacillus ferrooxidans	-	394125
diluted enzyme loses 10-15% of the activity each time it is frozen and thawed	Acidithiobacillus ferrooxidans	-	394125
4�C, purified enzyme, 10% loss of activity after 24 h, completely inactive after 7 days	Alcaligenes sp.	-	394123
frozen, 0.05 M phosphate buffer, pH 6.2, stable for at least 90 days	Alcaligenes sp.	-	394123
-20�C, crude extract, 50% loss of activity after 2 months	heterotrophic bacterium	-	394119
4�C, 50% loss of activity after 3 days, 75% loss of activity after 14 days	Pseudomonas aeruginosa	-	394116
-20�C, 36% loss of activity after 9 days	Pseudomonas sp.	-	394122
4�C, stable, 2 days	Pseudomonas sp.	-	394122
-20�C, the activity of cell-free extracts is stable for several days in the presence of 20% v/v glycerol, without glycerol most of the activity is lost after 2 days	Rhodotorula sp.	-	394078
-20�C, the activity of whole cells is stable for 3 months	Rhodotorula sp.	-	394078
4�C, cell-free extracts lose most of the activity after 2 days even in the presence of glycerol	Rhodotorula sp.	-	394078
the activity in cell-free extracts is lost very rapidly after freezing and thawing	Rhodotorula sp.	-	394078
20-30% loss of activity after freezing at -20�C and thawing	Thermithiobacillus tepidarius	-	288769
-25�C, 0.02 M phosphate, 40% loss of activity after 2 months	Thiobacillus sp.	-	394121
-20�C, the ability of the enzyme to couple with cytochrome c decreases during storage	Thiobacillus thioparus	-	394124
4�C, 10% loss of activity after 6 h and 50% loss of activity after 5 days	Thiobacillus thioparus	-	394124
frozen, stable, indefinitely as measured by ferricyanide reduction	Thiobacillus thioparus	-	394124

Purification/COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
using ammonium sulfate precipitation, hydrophobic interaction chromatography, anion-exchange chromatography and gel filtration	Acidiphilium acidophilum	-	394126, 394127
-	Acidithiobacillus ferrooxidans	-	689730
affinity chromatography with immobilized cytochrome c	Acidithiobacillus ferrooxidans	-	659545
using heat-treatment, 5-17% ethanol precipitation and CM-cellulose treatment	Acidithiobacillus ferrooxidans	-	394125
using chromatography on Phenyl-Sepharose column, CM-cellulose column and hydroxylapatite column	Acidithiobacillus thiooxidans	-	394129
using MnCl2 precipitation, treatment with calcium phosphate gel, and successive column chromatography on DEAE-Sephadex and Sephadex G-150	Alcaligenes sp.	-	394123
partial	Allochromatium vinosum	-	394117
using a Phenyl-Sepharose, a DEAE Sephacel and a Macroprep ceramic hydroxyapatite type I, and a Mono Q column	Allochromatium vinosum	-	676077
partial, using ultracentrifugation, ultrafiltration, column chromatography on DEAE-Sephadex A-25 and gel filtration on Sephadex S-200	Pseudomonas aeruginosa	-	394116
partial, using ion-exchange chromatography and calcium phosphate gel treatment	Pseudomonas sp.	-	394122
partial, using ultracentrifugation, ammonium sulfate fractionation, column chromatography on DEAE-cellulose and gel filtration on Sephacryl S-200	Rhodopila globiformis	-	394115
partial, using ion exchange chromatography, gel filtration and hydrophobic interaction chromatography	Thermithiobacillus tepidarius	-	288769, 394127
using chromatography on Phenyl-Sepharose column and Mono Q column, gel filtration on Superdex 200 and column chromatography on Phenyl Superose	Thiobacillus sp.	-	394128
using sonication, column chromatography on DEAE-cellulose, pH-adjustment to 4.5 and calcium phosphate gel treatment	Thiobacillus thioparus	-	394124

Cloned/COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
No entries in this field

EXPRESSION	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
No entries in this field

ENGINEERING	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

Renatured/COMMENTARY	ORGANISM	UNIPROT ACCESSION NO.	LITERATURE
No entries in this field

APPLICATION	ORGANISM	UNIPROT ACCESSION NO.	COMMENTARY	LITERATURE
No entries in this field

REF.	AUTHORS	TITLE	JOURNAL	VOL.	PAGES	YEAR	ORGANISM	LINK TO PUBMED	SOURCE
288769	Lu, W.P.; Kelly, D.P.	Cellular location and partial purification of the 'thiosulphate-oxidizing enzyme' and the 'trithionate hydrolase' from Thiobacillus tepidarius	J. Gen. Microbiol.	134	877-885	1988	Thermithiobacillus tepidarius	-
394078	Kurek, E.J.	Properties of an enzymatic complex active in sulfite and thiosulfate oxidation by Rhodotorula sp.	Arch. Microbiol.	143	277-282	1985	Rhodotorula sp.	-
394115	Then, J.; Truper, H.G.	The role of thiosulfate in sulfur metabolism of Rhodopseudomonas globiformis	Arch. Microbiol.	130	143-146	1981	Rhodopila globiformis	-
394116	Schook, L.B.; Berk, R.S.	Partial purification and characterization of thiosulfate oxidase from Pseudomonas aeruginosa	J. Bacteriol.	140	306-308	1979	Pseudomonas aeruginosa	PubMed
394117	Fukumori, Y.; Yamanaka, T.	A high potential nonheme iron protein (HiPIP)-Linked, thiosulfate-oxidizing enzyme derived from Chromatium vinosum	Curr. Microbiol.	3	117-120	1979	Allochromatium vinosum	-
394118	Lu, W.P.; Kelly, D.P.	Kinetic and energetic aspects of inorganic sulphur compound oxidation by Thiobacillus tepidarius	J. Gen. Microbiol.	134	865-876	1988	Thermithiobacillus tepidarius	-
394119	Trudinger, P.A.	Metabolism of thiosulfate and tetrathionate by heterotrophic bacteria from soil	J. Bacteriol.	93	550-559	1967	heterotrophic bacterium	PubMed
394120	Suzuki, I.	Mechanisms of inorganic oxidation and energy coupling	Annu. Rev. Microbiol.	28	85-101	1974	Acidithiobacillus ferrooxidans, Thiobacillus thioparus	PubMed
394121	Trudinger, P.A.	Thiosulfate oxidation and cytochromes in Thiobacillus X	Biochem. J.	78	680-686	1961	Thiobacillus sp.	PubMed
394122	Tuttle, J.H.; Schwartz, J.H.; Whited, G.M.	Some properties of thiosulfate-oxidizing enzyme from marine heterotroph 16B	Appl. Environ. Microbiol.	46	438-445	1983	Pseudomonas sp.	PubMed
394123	Hall, M.R.; Berk, R.S.	Thiosulfate oxidase from an Alcaligenes grown on mercaptosuccinate	Can. J. Microbiol.	18	235-245	1972	Alcaligenes sp.	PubMed
394124	Lyric, R.M.; Suzuki, I.	Enzymes involved in the metabolism of thiosulfate by Thiobacillus thioparus. 3. Properties of thiosulfate-oxidizing enzyme and proposed pathway of thiosulfate oxidation	Can. J. Biochem.	48	355-363	1970	Thiobacillus thioparus	PubMed
394125	Silver, M.; Lundgren, D.G.	The thiosulfate-oxidizing enzyme of Ferrobacillus ferrooxidans (Thiobacillus ferrooxidans)	Can. J. Biochem.	46	1215-1220	1968	Acidithiobacillus ferrooxidans	PubMed
394126	Meulenberg, R.; Pronk, J.T.; Hazeu, W.; van Dijken, J.P.; Frank, J.; Bos, P.; Kuenen, J.G.	Purification and partial characterization of thiosulfate dehydrogenase from Thiobacillus acidophilus	J. Gen. Microbiol.	139	2033-2039	1993	Acidiphilium acidophilum	-
394127	Kelly, D.P.; Wood, A.P.	Enzymes involved in microbiological oxidation of thiosulfate and polythionates	Methods Enzymol.	243	501-510	1994	Acidiphilium acidophilum, Halothiobacillus neapolitanus, Thermithiobacillus tepidarius	-
394128	Visser, J.M.; De Jong, G.A.H.; Robertson, L.A.; Kuenen, J.G.	Purification and characterization of a periplasmic thiosulfate dehydrogenase from the obligately autotrophic Thiobacillus sp. W5	Arch. Microbiol.	166	372-378	1996	Thiobacillus sp.	PubMed
394129	Nakamura, K.; Nakamura, M.; Yoshikawa, H.; Amano, Y.	Purification and properties of thiosulfate dehydrogenase from Acidithiobacillus thiooxidans JCM7814	Biosci. Biotechnol. Biochem.	65	102-108	2001	Acidithiobacillus thiooxidans	PubMed
659545	Janiczek, O.; Pokorna, B.; Zemanova, J.; Mandl, M.	Use of immobilized cytochrome c as a ligand for affinity chromatography of thiosulfate dehydrogenase from Acidithiobacillus ferrooxidans	J. Biotechnol.	117	293-298	2005	Acidithiobacillus ferrooxidans	PubMed
673503	Sorokin, D.Y.; Tourova, T.P.; Muyzer, G.	Oxidation of thiosulfate to tetrathionate by an haloarchaeon isolated from hypersaline habitat	Extremophiles	9	501-504	2005	halophilic bacterium	PubMed
676077	Hensen, D.; Sperling, D.; Trueper, H.G.; Brune, D.C.; Dahl, C.	Thiosulphate oxidation in the phototrophic sulphur bacterium Allochromatium vinosum	Mol. Microbiol.	62	794-810	2006	Allochromatium vinosum	PubMed
689730	Janiczek, O.; Zemanova, J.; Mandl, M.	Purification and some properties of thiosulfate dehydrogenase from Acidithiobacillus ferrooxidans	Prep. Biochem. Biotechnol.	37	101-111	2007	Acidithiobacillus ferrooxidans	PubMed
690014	Dam, B.; Mandal, S.; Ghosh, W.; Das Gupta, S.K.; Roy, P.	The S4-intermediate pathway for the oxidation of thiosulfate by the chemolithoautotroph Tetrathiobacter kashmirensis and inhibition of tetrathionate oxidation by sulfite	Res. Microbiol.	158	330-338	2007	Tetrathiobacter kashmirensis	PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 1.8.2.2)

NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM

IUBMB Enzyme Nomenclature

PROSITE Database of protein families and domains

SYSTERS

Protein Mutant Database

InterPro (database of protein families, domains and functional sites)

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