Information on EC 1.4.1.2 - glutamate dehydrogenase:
   PRINT
Please wait a moment until all data are loaded. This message will disappear when all data are loaded.
Mark a special word or phrase in this record:  
Select one or more organisms in this record:

Show additional data Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

Please login to have access to the AMENDA and FRENDA data

EC NUMBERCOMMENTARY
1.4.1.2-

RECOMMENDED NAMEGeneOntology No.
glutamate dehydrogenaseGO:0004352

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		----
L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		formation of an enzyme-NAD-oxoglutarate dead end complex; fully ordered reaction mechanism; NAD+ binds first followed by L-glutamateLupinus luteus-391543
L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		bi uni uni ping-pong addition sequenceChlorella sorokiniana-391545
L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		partially random mechanismPisum sativum-391546

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
oxidation----
redox reaction----
reduction----
reductive amination----

PATHWAYKEGG LinkMetaCyc Link
4-aminobutyrate degradation V-PWY-5022
alanine degradation II (to D-lactate)-ALACAT2-PWY
glutamate degradation I-GLUTAMATE-DEG1-PWY
glutamate degradation V (via hydroxyglutarate)-P162-PWY
methylaspartate cycle-PWY-6728

SYSTEMATIC NAMEIUBMB Comments
L-glutamate:NAD+ oxidoreductase (deaminating)-

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
CsGDHClostridium symbiosum--701137
dehydrogenase, glutamate----
GDH----
GDHVitis vinifera--657131
GDHTriticum aestivum--671178, 701268
GDHPyrobaculum islandicum--671995
GDHClostridium symbiosum--672020, 686665, 711875
GDHRattus norvegicus--673480
GDHEntodinium caudatumQ9TVN3-673715
GDHNicotiana tabacum--675147, 676596, 688076, 700719
GDHBos taurus--685127, 698313, 698927
GDHPeptoniphilus asaccharolyticus--686673, 710758
GDHHomo sapiens--688188, 697113
GDHBacillus subtilis--689048
GDHThermus thermophilus--697661
GDHEscherichia coli, Tetrahymena--698927
GDHStreptococcus suis--699188
GDHLupinus luteus--700651
GDH isoenzyme 1Nicotiana tabacum--676630, 694766
GDH isoenzyme 1Solanum lycopersicum--694766
GDH, NAD-dependentHaloferax mediterraneiQ977U6-673495
gdh-1Halobacillus halophilusQ0E5H9, Q0E5I0-674303
gdh-2Halobacillus halophilusQ0E5H9, Q0E5I0-674303
GDH1Oryza sativaQ852M0-670544
GDH1Nicotiana tabacumQ67C42, Q67C43-676690
GDH1Arabidopsis thaliana-beta subunit688076
GDH1Brassica napus-isozyme689656
GDH2Oryza sativaQ852M0-670544
GDH2Nicotiana tabacumQ67C42, Q67C43-676690
GDH2Arabidopsis thaliana-alpha subunit688076
GDH2Brassica napus-isozyme689656
GDH2Mycobacterium smegmatisA0R1C2-711601
GDH3Oryza sativaQ852M0-670544
GdhANicotiana plumbaginifolia-alpha subunit688076
GDHBNicotiana plumbaginifolia-beta subunit688076
GDHISalinibacter ruber--655623
Glu dehydrogenaseNicotiana tabacum--676596
GLUD1Chlorocebus sabaeusB5AAK2isozyme689705
GLUD1Gorilla gorillaB5AAK3isozyme689705
GLUD1Homo sapiens-isozyme689705
GLUD1Pan troglodytesB5AAJ9isozyme689705
GLUD1Pongo pygmaeusB5AAK0isozyme689705
GLUD1Symphalangus syndactylusB5AAK1isozyme689705
GLUD2Homo sapiens-isozyme689705
GluDHBacillus subtilisP39633-672661
glutamate dehydrogenaseTriticum aestivum--663075, 671178, 701268
glutamate dehydrogenaseOryza sativa--670544, 700724
glutamate dehydrogenasePyrobaculum islandicum--671995
glutamate dehydrogenaseClostridium symbiosum--672020, 673612, 697928, 701137
glutamate dehydrogenaseBacillus subtilis--672660, 672661
glutamate dehydrogenaseBrassica oleraceaQ50JE9-672773
glutamate dehydrogenaseHomo sapiens--673480, 695431, 697113
glutamate dehydrogenaseRattus norvegicus--673480
glutamate dehydrogenaseHalobacillus halophilusQ0E5H9, Q0E5I0; 674303
glutamate dehydrogenaseNicotiana tabacum--675147, 676630, 700719
glutamate dehydrogenaseThermus thermophilus--697661
glutamate dehydrogenaseBos taurus--698313, 698927
glutamate dehydrogenasePseudomonas fluorescens--698620
glutamate dehydrogenaseEscherichia coli, Tetrahymena--698927
glutamate dehydrogenaseMus musculus--698996
glutamate dehydrogenaseStreptococcus suis--699188
glutamate dehydrogenaseLupinus luteus--700651
glutamate dehydrogenase (NAD)----
glutamate dehydrogenase alpha subunitNicotiana tabacumQ67C42, Q67C43-676690
glutamate dehydrogenase beta subunitNicotiana tabacumQ67C42, Q67C43-676690
glutamate oxidoreductase----
glutamic acid dehydrogenase----
glutamic dehydrogenase----
hGDH1Homo sapiens--673480
hGDH2-nerve-specific GDHHomo sapiens--673480
house-keeping GDHHomo sapiens--673480
NAD(+)-dependent glutamate dehydrogenaseEntodinium caudatumQ9TVN3-673715
NAD(H)-dependent glutamate dehydrogenaseNicotiana tabacumQ67C42, Q67C43; 676690
NAD(H)-dependent glutamate dehydrogenaseNicotiana tabacum, Solanum lycopersicum--694766
NAD+-dependant glutamate dehydrogenaseMycobacterium smegmatisA0R1C2-711601
NAD+-dependent GDHPsychrobacter sp.--655253
NAD+-dependent GluDHBacillus subtilis--672660
NAD+-GDHMycobacterium smegmatisA0R1C2-711601
NAD+-glutamate dehydrogenaseThermus thermophilus--656633
NAD-dependent glutamate dehydrogenase----
NAD-dependent glutamate dehydrogenaseJanthinobacterium lividumA5LH94-711526
NAD-dependent glutamic dehydrogenase----
NAD-dependent L-glutamate dehydrogenaseJanthinobacterium lividumA5LH94-692832
NAD-GDH----
NAD-GDHPseudomonas aeruginosa--661800
NAD-GDHHaloferax mediterraneiQ977U6-673495
NAD-GDHAspergillus niger--686726, 697654
NAD-GDHBrassica napus--689656
NAD-GDHJanthinobacterium lividumA5LH94-692832
NAD-GDHBenjaminiella poitrasii--696792
NAD-glutamate dehydrogenase----
NAD-glutamate dehydrogenaseHaloferax mediterraneiQ977U6-673495
NAD-glutamate dehydrogenaseAspergillus niger--686726
NAD-glutamate dehydrogenaseBenjaminiella poitrasii--696792
NAD-linked glutamate dehydrogenase----
NAD-linked glutamic dehydrogenase----
NAD-specific glutamate dehydrogenase----
NAD-specific glutamic dehydrogenase----
NAD:glutamate oxidoreductase----
NADH-dependent GDHTriticum aestivum--663075
NADH-dependent glutamate dehydrogenase----
NADH-dependent glutamate dehydrogenaseTriticum aestivum--675664
NADH-GDHPhaseolus vulgaris--673970
NADH-GDHTriticum aestivum--675663, 675664
NADH-GDHLupinus luteusQ5BU42, Q5BU43, Q5BU44, Q5QDM6-688640
NADH-GDHBrassica napus--689656
NADH-glutamate dehydrogenasePhaseolus vulgaris--673970
NADH-linked glutamate dehydrogenase----
OsGDH1Oryza sativa--700724
OsGDH2Oryza sativa--700724
OsGDH3Oryza sativa--700724
RocGBacillus subtilis--689048
Surface-associated protein PGAG1----
t-GDHThermus thermophilus--656633
L-glutamate dehydrogenase----
additional informationMycobacterium smegmatisA0R1C2NAD+-specific glutamate dehydrogenases belongs to the L_180 class, that is affected by the binding of a small protein, GarA711601

CAS REGISTRY NUMBERCOMMENTARY
9001-46-1-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Acanthamoeba culbertsoni-391560--Manually annotated by BRENDA team
Achlya sp.-391541--Manually annotated by BRENDA team
Agaricus bisporus-391581--Manually annotated by BRENDA team
Agave americana-391562--Manually annotated by BRENDA team
Alicyclobacillus acidocaldarius-391578--Manually annotated by BRENDA team
Amphibacillus xylanus-391588--Manually annotated by BRENDA team
Apodachlya sp.-391541--Manually annotated by BRENDA team
Arabidopsis thaliana-688076--Manually annotated by BRENDA team
Arenicola marina-391557--Manually annotated by BRENDA team
Aspergillus niger-697654--Manually annotated by BRENDA team
Aspergillus nigerstrain NCIM 565686726--Manually annotated by BRENDA team
Aspergillus niger NCIM 565strain NCIM 565686726--Manually annotated by BRENDA team
Bacillus cereus-391555--Manually annotated by BRENDA team
Bacillus cereusstrain DSM 31391629--Manually annotated by BRENDA team
Bacillus subtilis-672660, 689048--Manually annotated by BRENDA team
Bacillus subtilisstrain ISW1214672661P39633UniprotManually annotated by BRENDA team
Bacillus subtilis ISW1214strain ISW1214672661P39633-Manually annotated by BRENDA team
Bacteroides fragilistwo enzymes GDHA and GDHB391577--Manually annotated by BRENDA team
Benjaminiella poitrasii-696792--Manually annotated by BRENDA team
Blastocladiella emersonii-391541--Manually annotated by BRENDA team
Bos taurus-391591, 685127, 698313--Manually annotated by BRENDA team
Bos taurus-698927P00366UniProtManually annotated by BRENDA team
Brassica napuscultivar Bronowski689656--Manually annotated by BRENDA team
Brassica oleracea-672773Q50JE9SwissProtManually annotated by BRENDA team
Chlorella sorokiniana-391545--Manually annotated by BRENDA team
Chlorocebus sabaeusfragment689705B5AAK2UniProtManually annotated by BRENDA team
Clostridium botulinum113B391566--Manually annotated by BRENDA team
Clostridium botulinum 113B113B391566--Manually annotated by BRENDA team
Clostridium difficile-391575--Manually annotated by BRENDA team
Clostridium sp.SB4391541--Manually annotated by BRENDA team
Clostridium symbiosum-391548, 391576, 672020, 673612, 686665, 697928, 701137--Manually annotated by BRENDA team
Clostridium symbiosum-656115, 711875P24295UniProtManually annotated by BRENDA team
Crithidia fasciculata-391544--Manually annotated by BRENDA team
Cucurbita pepo-391573--Manually annotated by BRENDA team
Cyberlindnera jadinii-391570--Manually annotated by BRENDA team
Dictyostelium discoideum-391549, 391585--Manually annotated by BRENDA team
Doryteuthis pealeii-391558--Manually annotated by BRENDA team
Emericella nidulans-391567--Manually annotated by BRENDA team
Entodinium caudatum-673715Q9TVN3SwissProtManually annotated by BRENDA team
Escherichia coli-698927--Manually annotated by BRENDA team
Geobacillus stearothermophilus-391451--Manually annotated by BRENDA team
Gorilla gorillafragment689705B5AAK3UniProtManually annotated by BRENDA team
Halobacillus halophilusstrain DSMZ 2266T674303Q0E5H9, Q0E5I0SwissProtManually annotated by BRENDA team
Halobacterium salinarumthe sequence has errornously been assigned as NADP+-dependent glutamate dehydrogenase in Benachenhou, N., Baldacci, G.: Mol. Gen. Genet, 230, 345-352 (1991)655606P29051SwissProtManually annotated by BRENDA team
Haloferax mediterraneistrain R4 (ATCC 33500)673495Q977U6SwissProtManually annotated by BRENDA team
Haloferax mediterranei R4strain R4 (ATCC 33500)673495Q977U6SwissProtManually annotated by BRENDA team
Homo sapiens-673480, 688188, 689705, 695431, 697113--Manually annotated by BRENDA team
Janthinobacterium lividum-711526A5LH94UniProtManually annotated by BRENDA team
Janthinobacterium lividumfragment; strain UTB1302692832A5LH94UniProtManually annotated by BRENDA team
Janthinobacterium lividum UTB1302fragment; strain UTB1302692832A5LH94UniProtManually annotated by BRENDA team
Kluyveromyces marxianus-391453--Manually annotated by BRENDA team
Laccaria bicolor-391583--Manually annotated by BRENDA team
Lemna minor-391568--Manually annotated by BRENDA team
Lupinus luteus-700651--Manually annotated by BRENDA team
Lupinus luteusEuropean yellow lupine688640Q5BU43UniProtManually annotated by BRENDA team
Lupinus luteusfragment; European yellow lupine688640Q5BU44UniProtManually annotated by BRENDA team
Lupinus luteusglutamate dehydrogenase 1, fragment; European yellow lupine688640Q5QDM6UniProtManually annotated by BRENDA team
Lupinus luteusglutamate dehydrogenase 2, fragment; European yellow lupine688640Q5BU42UniProtManually annotated by BRENDA team
Lupinus luteuslupin391543, 391547--Manually annotated by BRENDA team
Medicago sativa-391569--Manually annotated by BRENDA team
Micrococcus aerogenes-391541--Manually annotated by BRENDA team
Mus musculus-698996--Manually annotated by BRENDA team
Mycobacterium smegmatisgene msmeg_4699711601A0R1C2UniProtManually annotated by BRENDA team
Mytilus edulis-391554--Manually annotated by BRENDA team
Neurospora crassa-391541, 391550, 391552, 391556--Manually annotated by BRENDA team
Nicotiana plumbaginifolia-688076--Manually annotated by BRENDA team
Nicotiana tabacum-676596, 688076, 700719--Manually annotated by BRENDA team
Nicotiana tabacumcv. Xanthi XHFD8 and cv. Xanthi G28675147--Manually annotated by BRENDA team
Nicotiana tabacumline A63-H694766--Manually annotated by BRENDA team
Nicotiana tabacumtransgenic tobacco lines S4-H and S49-H, lines A63-NS and S49-NS as isogenic controls676630--Manually annotated by BRENDA team
Nicotiana tabacumvar.Ti68, sense lines S4, S49 and S77 and antisense lines A44, A62, A63, A68 and A69676690Q67C42, Q67C43SwissProtManually annotated by BRENDA team
Oryza sativa-670544Q852M0SwissProtManually annotated by BRENDA team
Oryza sativa; four putative GDH genes (OsGDH1-4) are present in the rice genome. The GDH sequences from rice and other species can be classified into two types (I and II). OsGDH1-3 belong to type II genes, whereas OsGDH4 belong to type I like gene700724--Manually annotated by BRENDA team
Pan troglodytesfragment689705B5AAJ9UniProtManually annotated by BRENDA team
Peptoniphilus asaccharolyticus-391541, 391551, 391571, 655641, 686673--Manually annotated by BRENDA team
Peptoniphilus asaccharolyticus-710758P28997UniProtManually annotated by BRENDA team
Phaseolus vulgaris-673970--Manually annotated by BRENDA team
Phycomyces blakesleeanus-391564--Manually annotated by BRENDA team
Pinus sylvestrisScots pine391574--Manually annotated by BRENDA team
Pisum sativum-391541, 391546, 391568--Manually annotated by BRENDA team
Pongo pygmaeusfragment689705B5AAK0UniProtManually annotated by BRENDA team
Pseudomonas aeruginosa-661800--Manually annotated by BRENDA team
Pseudomonas fluorescens-698620--Manually annotated by BRENDA team
Psychrobacter sp.strain TAD1655253--Manually annotated by BRENDA team
Psychrobacter sp.TAD 1, two enzymes391579--Manually annotated by BRENDA team
Psychrobacter sp. TAD1strain TAD1655253--Manually annotated by BRENDA team
Pyrobaculum islandicum-391589, 656554, 671995--Manually annotated by BRENDA team
Pyrococcus sp.-391582--Manually annotated by BRENDA team
Pythium debaryanum-391541--Manually annotated by BRENDA team
Rattus norvegicus-673480--Manually annotated by BRENDA team
Saccharomyces cerevisiae-391541--Manually annotated by BRENDA team
Salinibacter ruber-655623--Manually annotated by BRENDA team
Solanum lycopersicum-694766--Manually annotated by BRENDA team
Sporosarcina ureaeDSM 320391580--Manually annotated by BRENDA team
Starkeya novella-391541--Manually annotated by BRENDA team
Streptococcus suis-699188--Manually annotated by BRENDA team
Streptomyces clavuligerus-391586--Manually annotated by BRENDA team
Streptomyces fradiae-391587--Manually annotated by BRENDA team
Symbiodinium microadriaticum-391559--Manually annotated by BRENDA team
Symphalangus syndactylusfragment; also named Symphalangus syndactylus689705B5AAK1UniProtManually annotated by BRENDA team
Synechocystis sp.PCC 6803391542--Manually annotated by BRENDA team
Tetrahymena-698927--Manually annotated by BRENDA team
Thermotoga maritima-391590--Manually annotated by BRENDA team
Thermus thermophilus-697661--Manually annotated by BRENDA team
Thermus thermophilusHB8391584--Manually annotated by BRENDA team
Thermus thermophilusstrain HB8656633--Manually annotated by BRENDA team
Triticum aestivum-663075, 671178, 675664, 701268--Manually annotated by BRENDA team
Triticum aestivumcultivar Yumai 34675663--Manually annotated by BRENDA team
Vigna unguiculata-391553--Manually annotated by BRENDA team
Vitis vinifera-391561, 657131--Manually annotated by BRENDA team
Zea mays-391572--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
metabolismMycobacterium smegmatisA0R1C2NAD+-GDH plays an important role in nitrogen assimilation rather than glutamate catabolism, and is involved in the additional nitrogen assimilatory pathway via glutamate dehydrogenase, GDH. The specific activity of the deaminating NAD+-GDH reaction is mostly independent of nitrogen availability, overview, overview711601
physiological functionHomo sapiens-glucose deprivation in SF-188 cells results in an enhanced GDH activity. This results from the loss of glycolysis. Inhibition of Akt signaling, which facilitates glycolysis, increases GDH activity whereas overexpression of Akt suppresses it. Suppression of GDH activity with RNA interference or an inhibitor shows that the enzyme is dispensable in cells able to metabolize glucose but is required for cells to survive impairments of glycolysis brought about by glucose deprivation, 2-deoxyglucose, or Akt inhibition. Inhibition of GDH converts these glutamine-addicted SF-188 cells to glucose-addicted cells697113
physiological functionMus musculus-transgenic mice, betaGlud1-/-, are generated bearing a beta-cell-specific GDH deletion. In situ pancreatic perfusion reveals that glucose-stimulated insulin secretion is reduced by 37% in transgenic mice. Isolated islets with either constitutive or acute adenovirus-mediated knock-out of GDH show a 49 and 38% reduction in glucose-induced insulin release, respectively. Adenovirus-mediated re-expression of GDH in transgenic mice fully restores glucose-induced insulin release. In transgenic mice reduced secretory capacity results in lower plasma insulin levels in response to both feeding and glucose load, while body weight gain is preserved698996
physiological functionStreptococcus suis-GDH enzymes of 19 Streptococcus suis serotype 2 strains, consisting of 18 swine isolates and 1 human clinical isolate from a geographically varied collection, are analyzed by activity staining on a nondenaturing gel. DNA sequences contain base pair differences, but most are silent. Cluster analysis of the deduced amino acid sequences separated the isolates into three groups (ETI, ETII, ETIII). Gene exchange studies results in the change of ETI to ETII and vice versa. A spectrophotometric activity assay for GDH do not show significant differences between the groups699188
physiological functionLupinus luteus-sucrose starvation of lupine embryos leads to a rapid increase in the specific activity of GDH, immunoreactive beta-polypeptide and it is accompanied by appearance of new cathodal isoforms of enzyme, suggesting that isoenzymes induced in lupine embryos by sucrose starvation combine into GDH hexamers with the predominance of beta-GDH subunits synthetized under GDH1 gene control, treatment of cultivated embryos with 0.01 mM Cd2+ or Pb2+ results in ammonium accumulation in the tissues, accompanied by an increase in anabolic activity of GDH and activity of anodal isoenzymes700651
physiological functionNicotiana tabacum-transgenic tobacco plants overexpressing the two genes encoding the enzyme are generated. Using an in vivo real time 15 N-nuclear magnetic resonance (NMR) spectroscopy approach it is shown that, when the two GDH genes are overexpressed individually or simultaneously, the transgenic plant leaves do not synthesize glutamate in the presence of NH4+ when glutamine synthetase is inhibited. When the two GDH unlabeled substrates ammonium and glutamate are provided simultaneously with either (15N) glutamate or 15NH4+ respectively, it is found that the ammonium released from the deamination of glutamate is reassimilated by the enzyme glutamine synthase, suggesting the occurrence of a futile cycle recycling both ammonium and glutamate700719
physiological functionTriticum aestivum-a quantitative genetic study for elucidating the contribution of glutamine synthetase, glutamate dehydrogenase and other nitrogen-related physiological traits to the agronomic performance of common wheat is performed. A total of 148 quantitative trait loci are detected, 26 are detected for GDH activity spread over 13 chromosomes. A coincidence between a quantitative trait loci for GDH activity and a gene encoding GDH is also found on chromosome 2B701268

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
2-oxo-3-methylvalerate + NADPH + NH3L-isoleucine + NADP+ + H2O
show the reaction diagram		Bacillus subtilis-very low specificity of wild-type672660---
2-oxo-iso-caproate + NADPH + NH3L-norleucine + NADP+ + H2O
show the reaction diagram		Bacillus subtilis-very low specificity of wild-type672660---
2-oxo-iso-valerate + NADPH + NH3L-leucine + NADP+ + H2O
show the reaction diagram		Bacillus subtilis-low specificity of wild-type672660---
2-oxobutyrate + NADPH + NH32-aminobutyrate + NAD+ + H2O
show the reaction diagram		Bacillus subtilisP39633faint specificity672661--?
2-oxoglutarate + NADH + NH3L-glutamate + NAD+ + H2O
show the reaction diagram		Bacillus subtilisP39633-672661--r
2-oxoglutarate + NADH + NH3L-glutamate + NAD+ + H2O
show the reaction diagram		Rattus norvegicus--673480--?
2-oxoglutarate + NADH + NH3L-glutamate + NAD+ + H2O
show the reaction diagram		Bos taurus--698313--?
2-oxoglutarate + NADH + NH3L-glutamate + NAD+ + H2O
show the reaction diagram		Clostridium symbiosum--701137--r
2-oxoglutarate + NADH + NH3L-glutamate + NAD+ + H2O
show the reaction diagram		Psychrobacter sp.--655253--r
2-oxoglutarate + NADH + NH3L-glutamate + NAD+ + H2O
show the reaction diagram		Benjaminiella poitrasii--696792--?
2-oxoglutarate + NADH + NH3L-glutamate + NAD+ + H2O
show the reaction diagram		Entodinium caudatumQ9TVN3-673715--r
2-oxoglutarate + NADH + NH3L-glutamate + NAD+ + H2O
show the reaction diagram		Triticum aestivum-2fold increase in NADH-dependent GDH aminating activity 28 days after flowering663075--r
2-oxoglutarate + NADPH + NH3L-glutamate + NADP+ + H2O
show the reaction diagram		Homo sapiens--673480--r
2-oxoglutarate + NADPH + NH3L-glutamate + NADP+ + H2O
show the reaction diagram		Clostridium symbiosum--701137--r
2-oxoglutarate + NADPH + NH3L-glutamate + NADP+ + H2O
show the reaction diagram		Bacillus subtilis-wild-type enzyme highly specific for 2-oxoglutarate672660--r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Phaseolus vulgaris--673970--r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Thermus thermophilus--391584--r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Triticum aestivum--671178, 675664--r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Nicotiana tabacum--676596--r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Agaricus bisporus--391581--r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Cucurbita pepo--391573-391573r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Clostridium difficile--391575-391575r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Clostridium symbiosum--391576-391576r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Vitis vinifera--657131--?
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Alicyclobacillus acidocaldarius--391578--r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Streptomyces clavuligerus--391586--r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Laccaria bicolor--391583--r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Amphibacillus xylanus--391588--r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Nicotiana tabacumQ67C42, Q67C43-676690--r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Haloferax mediterraneiQ977U6-673495--r
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Vitis vinifera-in conjugation with glutamine synthase, the glutamate dehydrogenase plays a major role in controlling the translocation of organic carbon and nitrogen metabolites in both vegetative and reproductive organs. It is possible that the presence of glutamate dehydrogenase in multivesicular bodies within the flower receptacle is important for the recycling of carbon and nitrogen molecules in senescing tissues in which the enzyme is generally induced657131--?
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Salinibacter ruber-no significant activity of deamination reaction655623--ir
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Pyrococcus sp.--391582---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Bacillus subtilisP39633-672661---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Rattus norvegicus--673480---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Neurospora crassa--391541---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Aspergillus niger--697654---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Dictyostelium discoideum--391585---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Bacillus cereus--391629---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Peptoniphilus asaccharolyticus--655641---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Agaricus bisporus--391581---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Pinus sylvestris--391574---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Streptomyces fradiae--391587---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Cucurbita pepo--391573---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Blastocladiella emersonii--391541---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Clostridium symbiosum--672020, 701137---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Alicyclobacillus acidocaldarius--391578---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Streptomyces clavuligerus--391586---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Achlya sp.--391541---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Psychrobacter sp.--391579---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Laccaria bicolor--391583---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Pyrobaculum islandicum--391589---
2-oxoglutarate + NH4+ + NADPHL-glutamate + NADP+
show the reaction diagram		Entodinium caudatumQ9TVN3-673715---
beta-phenylpyruvate + NADPH + NH3L-phenylalanine + NADP+ + H2O
show the reaction diagram		Bacillus subtilis-low specificity of wild-type672660---
L-glutamate + H2O + NAD(P)+2-oxoglutarate + NH3 + NAD(P)H
show the reaction diagram		Bacillus cereus--391629-391629r
L-glutamate + H2O + NAD(P)+2-oxoglutarate + NH3 + NAD(P)H
show the reaction diagram		Brassica oleraceaQ50JE9-672773--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Pyrococcus sp.--391582--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Cyberlindnera jadinii--391570--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Thermus thermophilus--656633--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Thermus thermophilus--391584--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Homo sapiens--688188, 689705--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Saccharomyces cerevisiae--391541--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Bos taurus--685127--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Triticum aestivum--675663--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Triticum aestivum--671178--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Lupinus luteus--391543, 391547--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Geobacillus stearothermophilus--391451--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Emericella nidulans--391567--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Neurospora crassa--391541, 391550, 391552, 391556--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Aspergillus niger--686726--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Phycomyces blakesleeanus--391564--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Pisum sativum--391541, 391546, 391568--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Zea mays--391572--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Nicotiana tabacum--676630--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Nicotiana tabacum--676596, 688076--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Arabidopsis thaliana--688076--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Brassica napus--689656--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Dictyostelium discoideum--391585---
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Dictyostelium discoideum--391549--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Crithidia fasciculata--391544--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Bacillus cereus--391629---
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Bacillus cereus--391555--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Medicago sativa--391569--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Micrococcus aerogenes, Peptoniphilus asaccharolyticus--391541--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Peptoniphilus asaccharolyticus--391551, 391571, 686673--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Peptoniphilus asaccharolyticus--655641--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Bacteroides fragilis--391577--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Agaricus bisporus--391581--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Starkeya novella--391541--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Kluyveromyces marxianus--391453--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Pinus sylvestris--391574--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Streptomyces fradiae--391587--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Cucurbita pepo--391573--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Blastocladiella emersonii, Clostridium sp.--391541--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Vigna unguiculata--391553--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Lemna minor--391568--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Chlorella sorokiniana--391545--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Mytilus edulis--391554--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Arenicola marina--391557--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Clostridium botulinum--391566--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Clostridium difficile--391575--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Clostridium symbiosum--391548--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Clostridium symbiosumP24295-656115--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Clostridium symbiosum--686665--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Clostridium symbiosum--391576--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Vitis vinifera--391561--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Alicyclobacillus acidocaldarius--391578--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Sporosarcina ureae--391580--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Pythium debaryanum--391541--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Streptomyces clavuligerus--391586--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Apodachlya sp., Achlya sp.--391541--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Symbiodinium microadriaticum--391559--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Acanthamoeba culbertsoni--391560--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Agave americana--391562--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Psychrobacter sp.--391579--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Laccaria bicolor--391583--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Amphibacillus xylanus--391588--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Pyrobaculum islandicum--391589--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Pyrobaculum islandicum--671995--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Nicotiana plumbaginifolia--688076--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Haloferax mediterraneiQ977U6-673495--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Lupinus luteusQ5BU42, Q5BU43, Q5BU44, Q5QDM6-688640--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Chlorocebus sabaeusB5AAK2-689705--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Pan troglodytesB5AAJ9-689705--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Gorilla gorillaB5AAK3-689705--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Pongo pygmaeusB5AAK0-689705--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Symphalangus syndactylusB5AAK1-689705--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Janthinobacterium lividumA5LH94-711526--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Clostridium symbiosum--711875--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Peptoniphilus asaccharolyticusP28997-710758--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Synechocystis sp.-strict substrate specificity391542--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Doryteuthis pealeii-glutamate oxidation is favoured391558--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Crithidia fasciculata-control point for amino acid metabolism391544--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Doryteuthis pealeii-primary role in squid mantle muscle is in regulating the catabolism of amino acids for energy production391558--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Pseudomonas aeruginosa-the enzyme may be linked to oxygen through an electron-transport system661800--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Bacillus subtilis- RocG is exclusively devoted to L-glutamate degradation rather than to its synthesis689048--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Mycobacterium smegmatisA0R1C2reaction cycle, specificities of forward and reverse reactions, overview, reaction cycle, overview711601--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH
show the reaction diagram		Thermus thermophilus--697661--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH
show the reaction diagram		Nicotiana tabacum--694766--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH
show the reaction diagram		Pseudomonas fluorescens--698620--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH
show the reaction diagram		Solanum lycopersicum--694766--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH
show the reaction diagram		Clostridium symbiosum--697928--?
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH
show the reaction diagram		Clostridium symbiosum--701137--r
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH
show the reaction diagram		Janthinobacterium lividumA5LH94-692832--?
L-glutamate + H2O + NADP+2-oxoglutarate + NH3 + NADPH
show the reaction diagram		Peptoniphilus asaccharolyticus--655641--r
L-glutamate + H2O + NADP+2-oxoglutarate + NH3 + NADPH
show the reaction diagram		Benjaminiella poitrasii--696792--?
L-glutamate + H2O + NADP+2-oxoglutarate + NH3 + NADPH + H+
show the reaction diagram		Peptoniphilus asaccharolyticus-weak reaction686673--?
L-glutamate + NAD+ + H2O2-oxoglutarate + NADH + NH3
show the reaction diagram		Escherichia coli--698927--?
L-glutamate + NAD+ + H2O2-oxoglutarate + NADH + NH3
show the reaction diagram		Clostridium symbiosum--672020--r
L-glutamate + NAD+ + H2O2-oxoglutarate + NADH + NH3
show the reaction diagram		Halobacterium salinarumP29051-655606--?
L-glutamate + NAD+ + H2O2-oxoglutarate + NADH + NH3
show the reaction diagram		Bos taurusP00366-698927--?
L-glutamate + NAD+ + H2O2-oxoglutarate + NADH + NH3
show the reaction diagram		Tetrahymena--698927--?
L-glutamate + NAD+ + H2O2-oxoglutarate + NADH + NH3
show the reaction diagram		Triticum aestivum-progressive decrease in NAD-GDH deaminating activity from flowering to maturity663075--r
L-glutamate + NADP+ + H2O2-oxoglutarate + NADPH + NH3
show the reaction diagram		Clostridium symbiosum--701137--r
L-norvaline + H2O + NAD+2-oxopentanoate + NH3 + NADH
show the reaction diagram		Vigna unguiculata-at 40% the rate391553--?
L-norvaline + H2O + NAD+2-oxopentanoate + NH3 + NADH
show the reaction diagram		Lupinus luteus-deamination at 5% the rate of L-glutamate deamination391547--?
oxaloacetate + NADPH + NH3L-aspartate + NADP+ + H2O
show the reaction diagram		Bacillus subtilisP39633faint specificity672661--?
oxaloacetate + NADPH + NH3L-aspartate + NADP+ + H2O
show the reaction diagram		Bacillus subtilis-very low specificity of wild-type672660---
p-hydroxyphenylpyruvate + NADPH + NH3L-tyrosine + NADP+ + H2O
show the reaction diagram		Bacillus subtilis-very low specificity of wild-type672660---
pyruvate + NADPH + NH3L-alanine + NADP+ + H2O
show the reaction diagram		Bacillus subtilisP39633faint specificity672661--?
pyruvate + NADPH + NH3L-alanine + NADP+ + H2O
show the reaction diagram		Bacillus subtilis-very low specificity of wild-type672660---
L-serine + H2O + NAD+3-hydroxy-2-oxopropanoate + NH3 + NADH
show the reaction diagram		Vigna unguiculata-deamination at 29% the rate of L-glutamate deamination391553--?
additional information?-Clostridium symbiosum-L-alpha-amino-gamma-nitroaminobutyrate deamination at 0.5% the rate of deamination of L-glutamate391548--?
additional information?-Bacillus subtilisP39633no activity with L-aspartate, L-alanine, L-valine and L-serine672661---
additional information?-Bacillus subtilis-no specificity of wild-type for 2-ketohexonoate672660---
additional information?-Bacillus subtilis-RocG is able to bind to and concomitantly inactivate the activator protein GltC689048---
additional information?-Janthinobacterium lividumA5LH94inert reaction with L-glutamine, L-aspartate, L-alanine, L-leucine, L-valine, L-lysine, L-2-aminobutyrate, L-methionine, L-ornithine, L-phenylalanine, L-arginine, L-tryptophan, L-methionine, L-histidine, D-glutamate, and D-aspartate, the enzyme is not active with NADP+692832---

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
2-oxoglutarate + NH3 + NADHL-glutamate + H2O + NAD+
show the reaction diagram		Vitis vinifera-in conjugation with glutamine synthase, the glutamate dehydrogenase plays a major role in controlling the translocation of organic carbon and nitrogen metabolites in both vegetative and reproductive organs. It is possible that the presence of glutamate dehydrogenase in multivesicular bodies within the flower receptacle is important for the recycling of carbon and nitrogen molecules in senescing tissues in which the enzyme is generally induced657131--
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Symbiodinium microadriaticum--391559--
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Janthinobacterium lividumA5LH94-711526--
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Clostridium symbiosum--711875--
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Peptoniphilus asaccharolyticusP28997-710758--
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Crithidia fasciculata-control point for amino acid metabolism391544--
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Doryteuthis pealeii-primary role in squid mantle muscle is in regulating the catabolism of amino acids for energy production391558--
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Pseudomonas aeruginosa-the enzyme may be linked to oxygen through an electron-transport system661800--
L-glutamate + H2O + NAD+2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram		Mycobacterium smegmatisA0R1C2reaction cycle, specificities of forward and reverse reactions, overview711601--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
NAD(P)+Brassica oleraceaQ50JE9-672773 2D-image
NAD+Geobacillus stearothermophilus--391451 2D-image
NAD+Kluyveromyces marxianus--391453 2D-image
NAD+Pisum sativum--391541, 391546, 391568 2D-image
NAD+Neurospora crassa--391541, 391550, 391552, 391556 2D-image
NAD+Peptoniphilus asaccharolyticus--391541, 391551, 391571, 710758 2D-image
NAD+Achlya sp., Apodachlya sp., Blastocladiella emersonii, Clostridium sp., Micrococcus aerogenes, Pythium debaryanum, Saccharomyces cerevisiae, Starkeya novella--391541 2D-image
NAD+Synechocystis sp.--391542 2D-image
NAD+Lupinus luteus--391543, 391547 2D-image
NAD+Crithidia fasciculata--391544 2D-image
NAD+Chlorella sorokiniana--391545 2D-image
NAD+Clostridium symbiosum--391548, 391576, 656115, 672020, 686665, 711875 2D-image
NAD+Dictyostelium discoideum--391549, 391585 2D-image
NAD+Vigna unguiculata--391553 2D-image
NAD+Mytilus edulis--391554 2D-image
NAD+Bacillus cereus--391555 2D-image
NAD+Arenicola marina--391557 2D-image
NAD+Doryteuthis pealeii--391558 2D-image
NAD+Symbiodinium microadriaticum--391559 2D-image
NAD+Acanthamoeba culbertsoni--391560 2D-image
NAD+Vitis vinifera--391561 2D-image
NAD+Agave americana--391562 2D-image
NAD+Phycomyces blakesleeanus--391564 2D-image
NAD+Clostridium botulinum--391566 2D-image
NAD+Emericella nidulans--391567 2D-image
NAD+Lemna minor--391568 2D-image
NAD+Medicago sativa--391569 2D-image
NAD+Cyberlindnera jadinii--391570 2D-image
NAD+Zea mays--391572 2D-image
NAD+Cucurbita pepo--391573 2D-image
NAD+Pinus sylvestris--391574 2D-image
NAD+Clostridium difficile--391575 2D-image
NAD+Bacteroides fragilis--391577 2D-image
NAD+Alicyclobacillus acidocaldarius--391578 2D-image
NAD+Psychrobacter sp.--391579, 655253 2D-image
NAD+Sporosarcina ureae--391580 2D-image
NAD+Agaricus bisporus--391581 2D-image
NAD+Pyrococcus sp.--391582 2D-image
NAD+Laccaria bicolor--391583 2D-image
NAD+Thermus thermophilus--391584, 697661 2D-image
NAD+Streptomyces clavuligerus--391586 2D-image
NAD+Streptomyces fradiae--391587 2D-image
NAD+Amphibacillus xylanus--391588 2D-image
NAD+Pyrobaculum islandicum--391589, 656554 2D-image
NAD+Bacillus cereus-no activity with NADP+391629 2D-image
NAD+Halobacterium salinarumP29051-655606 2D-image
NAD+Peptoniphilus asaccharolyticus-highly specific for. The ratio for turnover number to Km-value is 405 times greater than for NADP+655641 2D-image
NAD+Triticum aestivum--671178, 675663 2D-image
NAD+Haloferax mediterraneiQ977U6-673495 2D-image
NAD+Clostridium symbiosum-protects against targeting the Cys320 in the active site by 5,5'-dithiobis(2-nitrobenzoate)673612 2D-image
NAD+Entodinium caudatumQ9TVN3-673715 2D-image
NAD+Nicotiana tabacum--676596, 688076 2D-image
NAD+Bos taurus--685127 2D-image
NAD+Aspergillus niger--686726 2D-image
NAD+Arabidopsis thaliana, Nicotiana plumbaginifolia--688076 2D-image
NAD+Homo sapiens--688188, 689705 2D-image
NAD+Lupinus luteusQ5BU42, Q5BU43, Q5BU44, Q5QDM6; ; ; 688640 2D-image
NAD+Bacillus subtilis--689048 2D-image
NAD+Brassica napus--689656 2D-image
NAD+Chlorocebus sabaeusB5AAK2-689705 2D-image
NAD+Gorilla gorillaB5AAK3-689705 2D-image
NAD+Pan troglodytesB5AAJ9-689705 2D-image
NAD+Pongo pygmaeusB5AAK0-689705 2D-image
NAD+Symphalangus syndactylusB5AAK1-689705 2D-image
NAD+Janthinobacterium lividumA5LH94dependent692832 2D-image
NAD+Nicotiana tabacum, Solanum lycopersicum-dependent694766 2D-image
NAD+Janthinobacterium lividumA5LH94-711526 2D-image
NAD+Mycobacterium smegmatisA0R1C2specific for711601 2D-image
NADHGeobacillus stearothermophilus--391451 2D-image
NADHKluyveromyces marxianus--391453 2D-image
NADHPisum sativum--391541, 391546, 391568 2D-image
NADHNeurospora crassa--391541, 391550, 391552, 391556 2D-image
NADHPeptoniphilus asaccharolyticus--391541, 391551, 391571, 710758 2D-image
NADHAchlya sp., Apodachlya sp., Blastocladiella emersonii, Clostridium sp., Micrococcus aerogenes, Pythium debaryanum, Saccharomyces cerevisiae, Starkeya novella--391541 2D-image
NADHSynechocystis sp.--391542 2D-image
NADHLupinus luteus--391543, 391547 2D-image
NADHCrithidia fasciculata--391544 2D-image
NADHChlorella sorokiniana--391545 2D-image
NADHClostridium symbiosum--391548, 656115 2D-image
NADHDictyostelium discoideum--391549 2D-image
NADHVigna unguiculata--391553 2D-image
NADHMytilus edulis--391554 2D-image
NADHBacillus cereus--391555 2D-image
NADHArenicola marina-no aminating activity either in presence of NADH or NADPH391557 2D-image
NADHDoryteuthis pealeii--391558 2D-image
NADHSymbiodinium microadriaticum--391559 2D-image
NADHAcanthamoeba culbertsoni--391560 2D-image
NADHVitis vinifera--391561, 657131 2D-image
NADHAgave americana--391562 2D-image
NADHPhycomyces blakesleeanus--391564 2D-image
NADHClostridium botulinum--391566 2D-image
NADHEmericella nidulans--391567 2D-image
NADHLemna minor--391568 2D-image
NADHMedicago sativa--391569 2D-image
NADHCyberlindnera jadinii--391570 2D-image
NADHZea mays--391572 2D-image
NADHPsychrobacter sp.--655253 2D-image
NADHSalinibacter ruber-no activity with NADPH655623 2D-image
NADHPeptoniphilus asaccharolyticus-the ratio for turnover number to Km-value is 1000fold greater than for NADPH655641 2D-image
NADHTriticum aestivum--671178, 675664 2D-image
NADHBacillus subtilisP39633does not prevent heat inactivation672661 2D-image
NADHRattus norvegicus--673480 2D-image
NADHHaloferax mediterraneiQ977U6-673495 2D-image
NADHPhaseolus vulgaris-gradual increase in enzyme activity with increasing concentrations of NADH in preparations with 0.1 mM Hg or without Hg673970 2D-image
NADHNicotiana tabacum--676596, 676630 2D-image
NADHPeptoniphilus asaccharolyticus-strong preference (1170fold) for NADH over NADPH686673 2D-image
NADHAspergillus niger--697654 2D-image
NADHClostridium symbiosum-the wild-type enzyme displays negative NAD+ cooperativity at pH 7 and pH 9 values697928 2D-image
NADHOryza sativa-OsGDH1 contains an NADH-specific motif; OsGDH2 gene contains an NADH-specific motif; OsGDH3 gene contains an NADH-specific motif700724 2D-image
NADHClostridium symbiosum-preferred coenzyme compared to NADP+701137 2D-image
NADHJanthinobacterium lividumA5LH94-711526 2D-image
NADHMycobacterium smegmatisA0R1C2specific for711601 2D-image
NADP+Lemna minor-less than 1% of the activity with NAD+391568 2D-image
NADP+Peptoniphilus asaccharolyticus-about 4% of the activity with NAD+391571 2D-image
NADP+Psychrobacter sp.--391579 2D-image
NADP+Peptoniphilus asaccharolyticus-highly specific for NAD+. The ratio for turnover number to Km-value for NAD+ is 405 times greater than for NADP+655641 2D-image
NADP+Homo sapiens--673480 2D-image
NADPHLupinus luteus-can replace NADH only at pH 6, not at pH 7-10391547 2D-image
NADPHClostridium symbiosum-rate with NADPH is 300times lower than with NADH391548 2D-image
NADPHVigna unguiculata-activity with NADH, NADPH and NAD+ in the ratio 126:2:1391553 2D-image
NADPHMytilus edulis-less than 1% of the activity with NADH391554 2D-image
NADPHAgave americana-with NADPH less than 10% of the activity with NADH391562 2D-image
NADPHLemna minor, Pisum sativum--391568 2D-image
NADPHPeptoniphilus asaccharolyticus-about 4% of the activity with NADH391571 2D-image
NADPHPeptoniphilus asaccharolyticus-the ratio for turnover number to Km-value for NADH is 1000fold greater than that for NADPH655641 2D-image
NADPHHomo sapiens--673480 2D-image
acetyl-NAD+Arenicola marina--391557 2D-image
additional informationSynechocystis sp.-no activity with NADPH and NADP+391542-
additional informationHaloferax mediterraneiQ977U6no activity with NADPH673495-
additional informationPeptoniphilus asaccharolyticusP28997NADP+ and NADPH are poor cofactors. The presence of an acidic residue at the P7 position, adjacent to the 2'-OH group, typically discriminates against NADP+. PaGDH contains a P7 glutamate and has high specificity for NAD(H), with a kcat/Km for NAD+ that is approximately 1000fold greater than that for NADP+710758-

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
Al3+Phaseolus vulgaris-enhances increase in GDH activity due to Hg673970
Ca2+Pisum sativum-activation of reductive amination; slight inhibition of oxidative deamination391546
Ca2+Vitis vinifera-activation of amination, no effect on deamination391561
Ca2+Lemna minor, Pisum sativum-required391568
Ca2+Medicago sativa-activation of partially purified enzyme391569
Ca2+Zea mays-amination is stimulated, deamination not influenced391572
Ca2+Cucurbita pepo-activation391573
Ca2+Pinus sylvestris-activation391574
Ca2+Laccaria bicolor-activation391583
Ca2+Oryza sativaQ852M0a putative EF-hand loop motif, which binds Ca2+ in the GDH2 and GDH3 proteins, but absent in GDH1670544
Cd2+Triticum aestivum-increases both GDH aminating and deaminating activity, accumulating in roots and shoots of seedlings not only increases GDH activity, but also modifies its coenzymatic specificity671178
Hg2+Phaseolus vulgaris-increases NADH-GDH activity substantially, however, specific activity of the enzyme decreases at lower concentration of Hg, and increases to lesser extent at higher concentration of Hg673970
KClHaloferax mediterraneiQ977U6activity with KCl slightly higher than with NaCl673495
Mg2+Laccaria bicolor-stimulation391583
Na+Triticum aestivum-after 5 days of NaCl treatments, the leaf NADH-GDH activity shows 22.58% and 105.37% enhancements at 150 and 300 mM NaCl, respectively675663
NaClHaloferax mediterraneiQ977U6-673495
NaClTriticum aestivum-22.58% and 105.37% enhancements of NADH-GDH activity at 150 and 300 mM NaCl, respectively675664
NH4+Entodinium caudatumQ9TVN3transcriptional upregulation673715
Zn2+Pisum sativum-activation of reductive amination391546
Zn2+Lemna minor, Pisum sativum-can replace Ca2+, requirement391568
Mn2+Pisum sativum-activation of reductive amination391546
additional informationEntodinium caudatumQ9TVN3high K+ concentrations up to 0.45 M have no influence on activity673715
additional informationHalobacillus halophilusQ0E5H9, Q0E5I0gdh-1 expression is not influenced by the salinity of the medium, no measurable glutamate dehydrogenase activity in cells grown in G10 mineral medium at various salinities; gdh-2 expression is very low at every salt concentration tested, no measurable glutamate dehydrogenase activity in cells grown in G10 mineral medium at various salinities674303

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
2-MethyleneglutarateAspergillus niger-potent competitive inhibitor686726 2D-image
2-oxoglutarateJanthinobacterium lividumA5LH94substrate inhibition711526 2D-image
3,3'-[(2-bromobenzene-1,4-diyl)di(E)ethene-2,1-diyl]bis(6-hydroxybenzoic acid)Bos taurus-i.e. BSB685127 2D-image
3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-oneBos taurusP00366inhibits GDH in a non-competitive manner with the Vmax being greatly affected without a very large change in Km. Crystal structures discloses that 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one or bithionol, respectively, bind as pairs of stacked compounds at hexameric 2-fold axes between the dimers of subunits698927 2D-image
3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-oneEscherichia coli, Tetrahymena-inhibits GDH in a non-competitive manner with the Vmax being greatly affected without a very large change in Km. Crystal structures discloses that 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one or bithionol, respectively, bind as pairs of stacked compounds at hexameric 2-fold axes between the dimers of subunits698927 2D-image
5,5'-dithiobis(2-nitrobenzoate)Crithidia fasciculata--391544 2D-image
5,5'-dithiobis(2-nitrobenzoate)Clostridium botulinum--391566 2D-image
5,5'-dithiobis(2-nitrobenzoate)Emericella nidulans--391567 2D-image
5,5'-dithiobis(2-nitrobenzoate)Clostridium symbiosum--673612 2D-image
ADPChlorella sorokiniana--391545 2D-image
ADPLupinus luteus--391547 2D-image
ADPClostridium botulinum--391566 2D-image
ADPPeptoniphilus asaccharolyticus--391571 2D-image
ADPClostridium difficile--391575 2D-image
ADPLaccaria bicolor--391583 2D-image
Al3+Phaseolus vulgaris-inhibits the enzyme activity in the absence of Hg673970 2D-image
Al3+Homo sapiens-as increasing the Al3+ concentration, the activity of GDH is firstly inhibited (at less than 0.03 mM), then activated (0.03-0.08 mM), and finally inhibited (above 0.08 mM) in the Tris-HCl buffer solution at pH 6.5 and 7.5688188 2D-image
alpha,gamma-Diethyl glutamateNeurospora crassa--391556 2D-image
alpha-ketoglutaratePisum sativum--391546 2D-image
AMPLupinus luteus--391547 2D-image
AMPArenicola marina--391557 2D-image
AMPClostridium botulinum--391566 2D-image
AMPPeptoniphilus asaccharolyticus--391571 2D-image
AMPClostridium difficile--391575 2D-image
AMPLaccaria bicolor--391583 2D-image
ATPCrithidia fasciculata--391544 2D-image
ATPArenicola marina--391557 2D-image
ATPDoryteuthis pealeii--391558 2D-image
ATPAgave americana-weak391562 2D-image
ATPClostridium botulinum--391566 2D-image
ATPPeptoniphilus asaccharolyticus--391571 2D-image
ATPLaccaria bicolor--391583 2D-image
ATPStreptomyces clavuligerus--391586 2D-image
ATP/GTP-competitive inhibitor of casein kinase-2Bos taurus--685127-
Aurintricarboxylic acidBos taurus--685127 2D-image
BH3I-2Bos taurus--685127 2D-image
BithionolBos taurus--685127 2D-image
BithionolBos taurusP00366inhibits GDH in a non-competitive manner with the Vmax being greatly affected without a very large change in Km. Crystal structures discloses that 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one or bithionol, respectively, bind as pairs of stacked compounds at hexameric 2-fold axes between the dimers of subunits698927 2D-image
BithionolEscherichia coli, Tetrahymena-inhibits GDH in a non-competitive manner with the Vmax being greatly affected without a very large change in Km. Crystal structures discloses that 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one or bithionol, respectively, bind as pairs of stacked compounds at hexameric 2-fold axes between the dimers of subunits698927 2D-image
Ca2+Pisum sativum-activation of reductive amination; slight inhibition of oxidative deamination391546 2D-image
Ca2+Vitis vinifera-activation of reductive amination; no effect on oxidative deamination391561 2D-image
Ca2+Bacteroides fragilis--391577 2D-image
CalmidazoliumBos taurus--685127 2D-image
chlortetracyclinAcanthamoeba culbertsoni--391560 2D-image
citrateLupinus luteus-inhibition of amination, no effect on deamination391547 2D-image
citrateJanthinobacterium lividumA5LH9467% activity in the presence of 10 mM citrate692832 2D-image
CMPAcanthamoeba culbertsoni--391560 2D-image
Co2+Janthinobacterium lividumA5LH9482% activity in the presence of 1 mM Co2+692832 2D-image
Cu2+Laccaria bicolor--391583 2D-image
Cu2+Streptomyces fradiae--391587 2D-image
D-asparagineJanthinobacterium lividumA5LH9493% activity in the presence of 10 mM D-asparagine692832 2D-image
D-AspartateJanthinobacterium lividumA5LH9490% activity in the presence of 10 mM D-aspartate692832 2D-image
D-glutamateJanthinobacterium lividumA5LH9494% activity in the presence of 10 mM D-glutamate692832 2D-image
D-glutamineJanthinobacterium lividumA5LH9495% activity in the presence of 10 mM D-glutamine692832 2D-image
DiethylstilbestrolBos taurus--685127 2D-image
dithiothreitolPeptoniphilus asaccharolyticus--391551 2D-image
DL-valineVigna unguiculata--391553 2D-image
DTNBClostridium symbiosum-inactivation via blocking of the only two Cys residues, Cys144 in helix alpha7a of domain I, the substrate-binding domain, and Cys320 in a loop that connects betak and alpha13 in domain II, the coenzyme-binding domain711875 2D-image
EDTALupinus luteus--391547 2D-image
EDTAVigna unguiculata--391553 2D-image
epicatechinBos taurus--685127 2D-image
epicatechin-3-monogallateBos taurus--685127 2D-image
epicatechin-monogallateBos taurus--685127 2D-image
epigallocatechinBos taurus--685127 2D-image
epigallocatechin-3,5-digallateBos taurus--685127 2D-image
epigallocatechin-3-gallateBos taurus--685127 2D-image
erythrosin BBos taurus--685127 2D-image
ethaverine hydrochlorideBos taurus--685127 2D-image
fumarateClostridium botulinum-amination391566 2D-image
fumarateJanthinobacterium lividumA5LH9432% activity in the presence of 10 mM fumarate692832 2D-image
Gallic acidBos taurus--685127 2D-image
GDPDoryteuthis pealeii--391558 2D-image
glutamateAcanthamoeba culbertsoni--391560 2D-image
glutamateClostridium botulinum-amination391566 2D-image
glutamineClostridium botulinum-amination391566 2D-image
glutaminePhaseolus vulgaris-reduces increase in GDH activity due to Hg673970 2D-image
glutathionePhaseolus vulgaris-reduces increase in GDH activity due to Hg673970 2D-image
glycogen accumulation regulatorMycobacterium smegmatisA0R1C2GarA, native or unphosphorylated GarA is able to interact with NAD+-GDH causing a reduction in NAD+-GDH activity by altering the affinity of the enzyme for its substrate. This binding is prevented by the phosphorylation of GarA by PknG711601-
GTPCrithidia fasciculata--391544 2D-image
GTPArenicola marina--391557 2D-image
GTPDoryteuthis pealeii--391558 2D-image
GTPPeptoniphilus asaccharolyticus--391571 2D-image
Guanidine hydrochlorideThermus thermophilus-72°C, almost complete loss of activity by addition of more than 3 M656633 2D-image
GW-5074Bos taurus--685127 2D-image
H2O2Clostridium botulinum--391566 2D-image
HexachloropheneBos taurus--685127 2D-image
HexachloropheneBos taurusP00366inhibits GDH in a non-competitive manner with the Vmax being greatly affected without a very large change in Km. Crystal structures discloses that hexachlorophene forms a ring around the internal cavity in GDH through aromatic stacking interactions between the drug and GDH as well as between the drug molecules themselves698927 2D-image
HexachloropheneEscherichia coli, Tetrahymena-inhibits GDH in a non-competitive manner with the Vmax being greatly affected without a very large change in Km. Crystal structures discloses that hexachlorophene forms a ring around the internal cavity in GDH through aromatic stacking interactions between the drug and GDH as well as between the drug molecules themselves698927 2D-image
Hg2+Clostridium botulinum--391566 2D-image
Hg2+Janthinobacterium lividumA5LH94no activity in the presence of 1 mM Hg2+692832 2D-image
iodoacetamideStreptomyces fradiae--391587 2D-image
iodoacetateCrithidia fasciculata-weak391544 2D-image
IsocitrateVigna unguiculata--391553 2D-image
IsocitrateAcanthamoeba culbertsoni--391560 2D-image
IsocitrateJanthinobacterium lividumA5LH9449% activity in the presence of 10 mM isocitrate692832 2D-image
IsophthalateNeurospora crassa--391552 2D-image
IsophthalateEmericella nidulans--391567 2D-image
IsophthalateAspergillus niger-potent in vitro inhibitor697654 2D-image
Isophthalic acidBenjaminiella poitrasii--696792 2D-image
KClSalinibacter ruber-3 M, 75% inhibition655623 2D-image
KCNLupinus luteus--391547 2D-image
L-aspartateCrithidia fasciculata-weak391544 2D-image
L-aspartateVigna unguiculata--391553 2D-image
L-glutamateJanthinobacterium lividumA5LH94substrate inhibition at L-glutamate concentrations above 20 mM692832 2D-image
L-glutamineJanthinobacterium lividumA5LH9489% activity in the presence of 10 mM L-glutamine692832 2D-image
L-histidineAcanthamoeba culbertsoni--391560 2D-image
L-Malic acidCrithidia fasciculata--391544 2D-image
L-ornithineJanthinobacterium lividumA5LH9483% activity in the presence of 10 mM L-ornithine692832 2D-image
leoidinBos taurus--685127 2D-image
malateJanthinobacterium lividumA5LH9465% activity in the presence of 10 mM malate692832 2D-image
metergolineBos taurus--685127 2D-image
Mg2+Acanthamoeba culbertsoni--391560 2D-image
Mg2+Bacteroides fragilis--391577 2D-image
Mg2+Janthinobacterium lividumA5LH9464% activity in the presence of 1 mM Mg2+692832 2D-image
Mn2+Phycomyces blakesleeanus-weak391564 2D-image
Mn2+Streptomyces fradiae-weak391587 2D-image
N-acetylglutamateNeurospora crassa--391556 2D-image
N-alpha-p-tosyl-L-lysine chloromethyl ketoneCucurbita pepo-TLCK391573 2D-image
N-CarbamylglutamateNeurospora crassa--391556 2D-image
N-ethylmaleimideCrithidia fasciculata--391544 2D-image
N-ethylmaleimideEmericella nidulans--391567 2D-image
N-ethylmaleimideCucurbita pepo--391573 2D-image
N-methylglutamateNeurospora crassa--391556 2D-image
NaClSalinibacter ruber-3 M, 89% inhibition655623 2D-image
NAD+Pisum sativum--391546 2D-image
NAD+Acanthamoeba culbertsoni--391560 2D-image
NADHPisum sativum--391546 2D-image
NADHStreptomyces clavuligerus--391586 2D-image
NADPHClostridium symbiosum-the wrong cofactor, NADPH, without the correct binding pocket to receive its 2'-phosphate, finds an alternative and catalytically unproductive way of occupying the coenzyme site711875 2D-image
NH4+Pisum sativum--391546 2D-image
NH4+Streptomyces clavuligerus--391586 2D-image
Ni2+Streptomyces fradiae--391587 2D-image
Ni2+Janthinobacterium lividumA5LH9477% activity in the presence of 1 mM Ni2+692832 2D-image
o-IodobenzoateCrithidia fasciculata--391544 2D-image
oxaloacetateClostridium botulinum-amination391566 2D-image
p-AminomercuribenzoateEmericella nidulans--391567 2D-image
p-chloromercuribenzoateCrithidia fasciculata--391544 2D-image
p-hydroxymercuribenzoateVigna unguiculata--391553 2D-image
p-hydroxymercuribenzoateStreptomyces fradiae--391587 2D-image
phosphoenolpyruvateCrithidia fasciculata-weak391544 2D-image
pyridoxal 5'-phosphateLupinus luteus--391547 2D-image
pyridoxal 5'-phosphateAcanthamoeba culbertsoni--391560 2D-image
pyridoxal 5'-phosphateAgave americana--391562 2D-image
Pyruvic acidCrithidia fasciculata--391544 2D-image
Pyruvic acidVigna unguiculata--391553 2D-image
succinateJanthinobacterium lividumA5LH9436% activity in the presence of 10 mM succinate692832 2D-image
suloctidilBos taurus--685127 2D-image
TaurineAcanthamoeba culbertsoni--391560 2D-image
Thiol reagentsEmericella nidulans--391567 2D-image
Zn2+Acanthamoeba culbertsoni--391560 2D-image
Zn2+Agave americana--391562 2D-image
Mn2+Janthinobacterium lividumA5LH9452% activity in the presence of 1 mM Mn2+692832 2D-image
additional informationPeptoniphilus asaccharolyticus-strong inhibition by increasing ionic strength391571-
additional informationBacillus cereus-no inhibition or activation in the presence of 500 mM AMP, ADP, ATP, cyclic-AMP, GMP, GDP or GTP391629-
additional informationPhaseolus vulgaris-increase in GDH activity due to Hg remains unaffected by the supply of sucrose673970-
additional informationNicotiana tabacum-Met sulfoximine and azaserine do not affect the aminating and deaminating activities of GDH676596-
additional informationJanthinobacterium lividumA5LH94not inhibited by NAD+692832-

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
acetonitrilePyrobaculum islandicum-activates391589 2D-image
ADPDictyostelium discoideum-stimulation391549 2D-image
ADPMytilus edulis-absolute requirement as cofactor391554 2D-image
ADPDoryteuthis pealeii-absolute requirement as cofactor; stimulation391558 2D-image
ADPPhycomyces blakesleeanus-stimulation391564 2D-image
ADPSalinibacter ruber-activates in presence of 3 M NaCl or 3 M KCl. Inhibition in absence of salts655623 2D-image
ADPBos taurus-ADP can reverse inhibition685127 2D-image
Al3+Homo sapiens-GDH is activated at 0.03-0.08 mM in the Tris-HCl buffer solution at pH 6.5 and 7.5688188 2D-image
alkalized extractHomo sapiens-from the tuber of Corydalis ternata, activates the hGDH1 up to 3.2fold and hGDH2 up to 4.1fold, hGDH2 is more sensitively affected by 1 mM ADP than hGDH1 on the activation by alkalized extracts673480-
alkalized extractRattus norvegicus-from the tuber of Corydalis ternata, increases GDH activity 2.4fold after one year of feeding673480-
AMPDictyostelium discoideum-stimulation391549, 391585 2D-image
AMPDoryteuthis pealeii-stimulation391558 2D-image
AMPAcanthamoeba culbertsoni-stimulation391560 2D-image
AMPPhycomyces blakesleeanus-required391564 2D-image
AMPStreptomyces clavuligerus-stimulation391586 2D-image
asparagineStreptomyces clavuligerus-activates391586 2D-image
aspartateStreptomyces clavuligerus-activates391586 2D-image
ATPSalinibacter ruber-activates in presence of 3 M NaCl or 3 M Kcl, slight activation in absence of salts655623 2D-image
D-ArginineJanthinobacterium lividumA5LH94212% activity in the presence of 10 mM D-arginine692832 2D-image
dAMPDictyostelium discoideum-stimulation391549 2D-image
ethyleneNicotiana tabacum-increase in the expression of GDH and the aminating GDH activity675147 2D-image
ethyleneBrassica napus-induces protein expression689656 2D-image
Guanidine hydrochloridePyrobaculum islandicum-activates391589 2D-image
H2O2Nicotiana tabacum-increase in the aminating GDH activity correlating with gene expression, in a dose-dependent manner675147 2D-image
heatingPyrobaculum islandicum-at 90°C the activity of the recombinant enzyme increases to a level comparable to that of the native enzyme671995-
jasmonic acidNicotiana tabacum-increase in the expression of GDH and the aminating GDH activity675147 2D-image
jasmonic acidBrassica napus-5 mM, induces protein expression689656 2D-image
L-arginineJanthinobacterium lividumA5LH94936% activity in the presence of 10 mM L-arginine692832 2D-image
L-asparagineJanthinobacterium lividumA5LH94118% activity in the presence of 10 mM L-asparagine692832 2D-image
L-aspartateJanthinobacterium lividumA5LH941735% activity in the presence of 10 mM L-aspartate692832 2D-image
L-aspartateJanthinobacterium lividumA5LH94catalytic activator, 2fold activation at 0.1 mM, effect on enzyme kinetics, overview711526 2D-image
L-cysteineAcanthamoeba culbertsoni-stimulates deamination391560 2D-image
L-HisSalinibacter ruber-activates in presence of 3 M NaCl, 3 M Kcl or in absence of salts655623 2D-image
L-histidineJanthinobacterium lividumA5LH94155% activity in the presence of 10 mM L-histidine692832 2D-image
L-LeuSalinibacter ruber-activates in presence of 3 M NaCl, 3 M Kcl or in absence of salts655623 2D-image
L-lysineJanthinobacterium lividumA5LH94161% activity in the presence of 10 mM L-lysine692832 2D-image
L-methionineJanthinobacterium lividumA5LH94206% activity in the presence of 10 mM L-methionine692832 2D-image
L-tryptophanJanthinobacterium lividumA5LH94235% activity in the presence of 10 mM L-tryptophan692832 2D-image
NaClNicotiana tabacum-high NaCl induces the formation of reactive oxygen species, which in turn induces the synthesis of the alpha-subunit of GDH688076 2D-image
NaNO3Oryza sativaQ852M0GDH1 transcripts slightly and slowly increase by 2fold after N nutrition addition while GDH2 mRNA is not affected670544 2D-image
NH3Brassica napus-GDH is activated by excess ammonia689656 2D-image
NH4ClOryza sativaQ852M0rapid and marked increase in the accumulation of mRNAs for GDH1 and GDH2 after supply670544 2D-image
NH4NO3Phaseolus vulgaris-increases the NADH-GDH activity in the presence of Hg673970 2D-image
protopineHomo sapiens-activates the human GDH isozymes, but to a less extent673480 2D-image
protopineRattus norvegicus-increases GDH activity 1.6fold673480 2D-image
salicylic acidNicotiana tabacum-increase in the expression of GDH675147 2D-image
salicylic acidBrassica napus-induces protein expression689656 2D-image
TetrahydrofuranPyrobaculum islandicum-activates391589 2D-image
UreaThermus thermophilus-72°C, maximal enhancement at 2 mM656633 2D-image
UreaPyrobaculum islandicum-at 5 M the activity of the recombinant enzyme increases to a level comparable to that of the native enzyme, urea-induced activation of recombinant GDH is irreversible671995 2D-image
Zn2+Janthinobacterium lividumA5LH94224% activity in the presence of 1 mM Zn2+692832 2D-image
leucineDoryteuthis pealeii-stimulation391558 2D-image
additional informationBacillus cereus-no inhibition or activation in the presence of 500 mM AMP, ADP, ATP, cyclic-AMP, GMP, GDP or GTP391629-
additional informationNicotiana tabacum-cryptogein and Onozuka R10 induce GDH expression, GDH activity is correlated with GDH expression and the GDH enzyme preferentially catalyses the aminating reaction; GDH mRNA accumulates preferentially in plants inoculated with the avirulent Pseudomonas syringae pv. syringae CFBP3077 (hrp+) and the virulent Pseudomonas syringae pv. tabaci CFBP1503 strains, induction of GDH expression by bacterial infection dependeds on the hrp- genotype, but not on the virulence/avirulence genotype; leaf GDH aminating-activity increases, whereas deaminating-activity is not affected by infection with viruses CMV, TEV, and PVY675147-
additional informationNicotiana tabacumQ67C42, Q67C43prolonged dark-stress increases GDH activity, more likely due to resistance of the GDH protein to stress-induced proteolysis, rather than to post-translational up-regulation; prolonged dark-stress increases GDH activity, more likely due to resistance of the GDH protein to stress-induced proteolysis, rather than to post-translational up-regulation676690-

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.00111-2-oxoglutarateRattus norvegicus-animals treated with alkalized extract from the tuber of Corydalis ternata673480 2D-image
0.00131-2-oxoglutarateRattus norvegicus-animals treated with protopine673480 2D-image
0.00138-2-oxoglutarateRattus norvegicus-control group673480 2D-image
0.041-2-oxoglutarateJanthinobacterium lividumA5LH94pH 6.5, 25°C, recombinant enzyme, in presence of 10 mM L-aspartate711526 2D-image
0.066-2-oxoglutaratePyrobaculum islandicum--391589 2D-image
0.0862-2-oxoglutarateClostridium symbiosum-mutant D165N672020 2D-image
0.103-2-oxoglutaratePeptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
0.125-2-oxoglutarateClostridium symbiosum-wild-type672020 2D-image
0.2-2-oxoglutaratePyrococcus sp.--391582 2D-image
0.56-2-oxoglutarateBlastocladiella emersonii--391541 2D-image
0.65-2-oxoglutarateBacillus subtilis-wild-type672660 2D-image
0.65-2-oxoglutarateBacillus subtilisP39633wild-type672661 2D-image
0.71-2-oxoglutarateEntodinium caudatumQ9TVN3-673715 2D-image
0.75-2-oxoglutarateDictyostelium discoideum-activated NAD-GDH391585 2D-image
0.93-2-oxoglutarateBacillus subtilisP39633mutant E27F672661 2D-image
1.22-2-oxoglutarateBacillus subtilisP39633mutant Q144R672661 2D-image
1.35-2-oxoglutarateLaccaria bicolor--391583 2D-image
1.7-2-oxoglutaratePinus sylvestris--391574 2D-image
1.9-2-oxoglutarateDictyostelium discoideum-non-activated NAD-GDH391585 2D-image
2.36-2-oxoglutaratePsychrobacter sp.-NAD+-dependent enzyme391579 2D-image
2.36-2-oxoglutaratePsychrobacter sp.-pH 8.0, 20°C655253 2D-image
2.85-2-oxoglutarateClostridium symbiosum-wild-type CsGDH, Vmax: 546 micromol/min/mg, pH 8.0, 25°C701137 2D-image
3.3-2-oxoglutarateAchlya sp.--391541 2D-image
3.3-2-oxoglutarateCucurbita pepo--391573 2D-image
3.4-2-oxoglutarateStreptomyces fradiae--391587 2D-image
4.6-2-oxoglutarateNeurospora crassa--391541 2D-image
5.6-2-oxoglutarateSalinibacter ruber-pH 8.0655623 2D-image
100-2-oxoglutarateBacillus subtilis-mutant M101S672660 2D-image
285-2-oxoglutarateClostridium symbiosum-chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH, 781 mM NH4Cl, Vmax: 2260 micromol/min/mg, pH 8.0, 25°C701137 2D-image
606-2-oxoglutarateClostridium symbiosum-chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH, 1800 mM NH4Cl, Vmax: 200 micromol/min/mg, pH 8.0, 25°C701137 2D-image
5.82-glutamatePeptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
7.4-glutamateBacillus cereus--391629 2D-image
0.00299-L-glutamateRattus norvegicus-animals treated with protopine673480 2D-image
0.00302-L-glutamateRattus norvegicus-animals treated with alkalized extract from the tuber of Corydalis ternata673480 2D-image
0.00321-L-glutamateRattus norvegicus-control group673480 2D-image
0.16-L-glutamatePyrobaculum islandicum-native enzyme; recombinant, heat-activated enzyme671995 2D-image
0.17-L-glutamatePyrobaculum islandicum--391589 2D-image
0.18-L-glutamatePyrobaculum islandicum-recombinant, urea-activated enzyme671995 2D-image
0.24-L-glutamateLaccaria bicolor--391583 2D-image
0.34-L-glutamateBacillus subtilisP39633wild-type672661 2D-image
0.39-L-glutamateBos taurusP003660.009 mM inhibitor biothionol, Vmax: 0.05, pH 7.5698927 2D-image
1.06-L-glutamateBos taurusP003660.005 mM inhibitor biothionol, Vmax: 0.1, pH 7.5698927 2D-image
1.17-L-glutamateBos taurusP003660.003 mM inhibitor biothionol, Vmax: 0.14, pH 7.5698927 2D-image
1.27-L-glutamateBos taurusP003660.008 mM inhibitor 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one, Vmax: 0.05, pH 7.5698927 2D-image
1.38-L-glutamateBos taurusP003660.0015 mM inhibitor 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one, Vmax: 0.13, pH 7.5; without inhibitor 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one, Vmax: 0.17, pH 7.5698927 2D-image
1.39-L-glutamateClostridium symbiosum-wild-type CsGDH, Vmax: 47.1 micromol/min/mg, pH 8.0, 25°C701137 2D-image
1.4-L-glutamateBlastocladiella emersonii--391541 2D-image
1.53-L-glutamateBos taurusP003660.004 mM inhibitor 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one, Vmax: 0.09, pH 7.5698927 2D-image
1.62-L-glutamateBos taurusP00366without inhibitor biothionol, Vmax: 0.18, pH 7.5698927 2D-image
2.66-L-glutamateClostridium symbiosum-mutant D165N672020 2D-image
3.1-L-glutamateAchlya sp.--391541 2D-image
3.25-L-glutamateClostridium symbiosum-mutant enzyme W393F, in 0.1 M potassium phosphate buffer, at pH 7.0 and 25°C; wild type enzyme, in 0.1 M potassium phosphate buffer, at pH 7.0 and 25°C686665 2D-image
3.3-L-glutamateClostridium symbiosum-mutant enzyme W449F, in 0.1 M potassium phosphate buffer, at pH 7.0 and 25°C686665 2D-image
3.41-L-glutamateClostridium symbiosum-mutant enzyme W64F, in 0.1 M potassium phosphate buffer, at pH 7.0 and 25°C686665 2D-image
3.75L-glutamateClostridium symbiosum-mutant enzyme W310F, in 0.1 M potassium phosphate buffer, at pH 7.0 and 25°C686665 2D-image
3.97-L-glutamateClostridium symbiosum-wild-type672020 2D-image
4.3-L-glutamateClostridium difficile--391575 2D-image
5.5-L-glutamateNeurospora crassa--391541 2D-image
7.1-L-glutamateJanthinobacterium lividumA5LH94in the presence of 5 mM NAD+, in 100 mM glycine/NaOH (pH 9.5), at 25°C692832 2D-image
18.2-L-glutamateClostridium symbiosum-mutant enzyme W243F, in 0.1 M potassium phosphate buffer, at pH 7.0 and 25°C686665 2D-image
25-L-glutamateAlicyclobacillus acidocaldarius--391578 2D-image
28.6-L-glutamatePsychrobacter sp.-NAD+-dependent enzyme391579 2D-image
28.6-L-glutamatePsychrobacter sp.-pH 8.0, 20°C655253 2D-image
32.2-L-glutamateStreptomyces fradiae--391587 2D-image
37.1-L-glutamateAgaricus bisporus--391581 2D-image
49-L-glutamateThermus thermophilus--391584 2D-image
98-L-glutamateEntodinium caudatumQ9TVN3-673715 2D-image
0.018-NAD+Pyrobaculum islandicum-recombinant, urea-activated enzyme671995 2D-image
0.019-NAD+Pyrobaculum islandicum-native enzyme671995 2D-image
0.021-NAD+Pyrobaculum islandicum-recombinant, heat-activated enzyme671995 2D-image
0.025-NAD+Pyrobaculum islandicum--391589 2D-image
0.046-NAD+Agaricus bisporus--391581 2D-image
0.076-NAD+Clostridium symbiosum-mutant D165N672020 2D-image
0.08-NAD+Bacillus subtilisP39633wild-type672661 2D-image
0.125-NAD+Clostridium symbiosum-wild type enzyme, in 0.1 M potassium phosphate buffer, at pH 7.0 and 25°C686665 2D-image
0.138-NAD+Clostridium symbiosum-mutant enzyme W393F, in 0.1 M potassium phosphate buffer, at pH 7.0 and 25°C686665 2D-image
0.14-NAD+Clostridium symbiosum-wild-type672020 2D-image
0.14-NAD+Bos taurusP003660.008 mM inhibitor 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one, Vmax: 0.04, pH 7.5698927 2D-image
0.168-NAD+Clostridium symbiosum-wild-type CsGDH, Vmax: 40.6 micromol/min/mg, pH 8.0, 25°C701137 2D-image
0.22-NAD+Clostridium symbiosum-mutant enzyme W449F, in 0.1 M potassium phosphate buffer, at pH 7.0 and 25°C686665 2D-image
0.23-NAD+Clostridium symbiosum-mutant enzyme W64F, in 0.1 M potassium phosphate buffer, at pH 7.0 and 25°C686665 2D-image
0.23-NAD+Bos taurusP003660.0015 mM inhibitor 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one, Vmax: 0.13, pH 7.5698927 2D-image
0.26-NAD+Bos taurusP003660.004 mM inhibitor 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one, Vmax: 0.09, pH 7.5; 0.009 mM inhibitor biothionol, Vmax: 0.05, pH 7.5698927 2D-image
0.27-NAD+Thermus thermophilus--391584 2D-image
0.28-NAD+Laccaria bicolor--391583 2D-image
0.3-NAD+Streptomyces fradiae--391587 2D-image
0.31-NAD+Bos taurusP00366without inhibitor 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one, Vmax: 0.24, pH 7.5; without inhibitor biothionol, Vmax: 0.24, pH 7.5698927 2D-image
0.33-NAD+Neurospora crassa--391541 2D-image
0.345-NAD+Peptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
0.35-NAD+Alicyclobacillus acidocaldarius--391578 2D-image
0.35-NAD+Clostridium symbiosum-mutant enzyme W310F, in 0.1 M potassium phosphate buffer, at pH 7.0 and 25°C686665 2D-image
0.36-NAD+Bos taurusP003660.005 mM inhibitor biothionol, Vmax: 0.13, pH 7.5698927 2D-image
0.4-NAD+Blastocladiella emersonii--391541 2D-image
0.4-NAD+Clostridium symbiosum-mutant enzyme W243F, in 0.1 M potassium phosphate buffer, at pH 7.0 and 25°C686665 2D-image
0.43-NAD+Bos taurusP003660.003 mM inhibitor biothionol, Vmax: 0.22, pH 7.5698927 2D-image
0.5-NAD+Psychrobacter sp.-NAD+-dependent enzyme391579 2D-image
0.5-NAD+Psychrobacter sp.-pH 8.0, 20°C655253 2D-image
0.56-NAD+Bacillus cereus--391629 2D-image
0.61-NAD+Achlya sp.--391541 2D-image
0.8-NAD+Clostridium difficile--391575 2D-image
2.1-NAD+Janthinobacterium lividumA5LH94in the presence of 20 mM L-glutamate, in 100 mM glycine/NaOH (pH 9.5), at 25°C692832 2D-image
0.0044-NADHPeptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
0.0044-NADHPeptoniphilus asaccharolyticus-wild type enzyme, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
0.005-NADHPyrobaculum islandicum--391589 2D-image
0.0056-NADHClostridium symbiosum-mutant D165N672020 2D-image
0.0076-NADHPeptoniphilus asaccharolyticus-mutant enzyme W244S, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
0.0108-NADHClostridium symbiosum-wild-type672020 2D-image
0.0123-NADHPeptoniphilus asaccharolyticus-mutant enzyme E243D, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
0.018-NADHPeptoniphilus asaccharolyticus-mutant enzyme D245K, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
0.033-NADHBlastocladiella emersonii--391541 2D-image
0.036-NADHPeptoniphilus asaccharolyticus-mutant enzyme E243K, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
0.03609-NADHRattus norvegicus-control group673480 2D-image
0.037-NADHDictyostelium discoideum-non-activated NAD-GDH391585 2D-image
0.03785-NADHRattus norvegicus-animals treated with protopine673480 2D-image
0.03833-NADHRattus norvegicus-animals treated with alkalized extract from the tuber of Corydalis ternata673480 2D-image
0.0385-NADHPeptoniphilus asaccharolyticus-mutant enzyme E243R, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
0.05-NADHStreptomyces fradiae--391587 2D-image
0.055-NADHAchlya sp.--391541 2D-image
0.055-NADHClostridium symbiosum-wild-type CsGDH, Vmax: 285 micromol/min/mg, pH 8.0, 25°C701137 2D-image
0.06-NADHAgaricus bisporus--391581 2D-image
0.07-NADHAlicyclobacillus acidocaldarius--391578 2D-image
0.07-NADHBacillus subtilis-wild-type672660 2D-image
0.07-NADHBacillus subtilisP39633wild-type672661 2D-image
0.089-NADHLaccaria bicolor--391583 2D-image
0.09-NADHDictyostelium discoideum-activated NAD-GDH391585 2D-image
0.091-NADHBacillus subtilis-mutant M101S672660 2D-image
0.095-NADHBacillus subtilis-mutant G82K672660 2D-image
0.14-NADHPyrococcus sp.--391582 2D-image
0.16-NADHBacillus subtilisP39633mutant E27F672661 2D-image
0.19-NADHSalinibacter ruber-pH 8.0655623 2D-image
0.41-NADHBacillus subtilisP39633mutant Q144R672661 2D-image
0.55-NADHNeurospora crassa--391541 2D-image
42.5-NADHPinus sylvestris--391574 2D-image
0.163-NADP+Clostridium symbiosum-chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH, Vmax: 80.8 micromol/min/mg, pH 8.0, 25°C701137 2D-image
3.7-NADP+Peptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
0.0384-NADPHPeptoniphilus asaccharolyticus-mutant enzyme E243R, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
0.053-NADPHPeptoniphilus asaccharolyticus-mutant enzyme E243K, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
0.065-NADPHPyrococcus sp.--391582 2D-image
0.238-NADPHPeptoniphilus asaccharolyticus-mutant enzyme D245K, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
0.431-NADPHPeptoniphilus asaccharolyticus-mutant enzyme W244S, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
0.476-NADPHPeptoniphilus asaccharolyticus-mutant enzyme E243D, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
0.51-NADPHClostridium symbiosum-chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH, Vmax: 2180 micromol/min/mg, pH 8.0, 25°C701137 2D-image
1.64-NADPHPeptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
1.64-NADPHPeptoniphilus asaccharolyticus-wild type enzyme, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
24.6-NH3Psychrobacter sp.-pH 8.0, 20°C655253 2D-image
33.9-NH3Janthinobacterium lividumA5LH94as NH4+, pH 6.5, 25°C, recombinant enzyme, in absence of L-aspartate711526 2D-image
300-NH3Salinibacter ruber-pH 8.0655623 2D-image
0.00528-NH4+Rattus norvegicus-animals treated with alkalized extract from the tuber of Corydalis ternata673480 2D-image
0.0054-NH4+Rattus norvegicus-animals treated with protopine673480 2D-image
0.00613-NH4+Rattus norvegicus-control group673480 2D-image
0.033-NH4+Bacillus cereus-for 200 mM NH4+391629 2D-image
0.98-NH4+Pyrococcus sp.--391582 2D-image
2.33-NH4+Entodinium caudatumQ9TVN3-673715 2D-image
6.5-NH4+Agaricus bisporus--391581 2D-image
9.7-NH4+Pyrobaculum islandicum--391589 2D-image
12.9-NH4+Clostridium symbiosum-wild-type CsGDH, Vmax: 307 micromol/min/mg, pH 8.0, 25°C701137 2D-image
14.2-NH4+Streptomyces fradiae--391587 2D-image
17-NH4+Neurospora crassa--391541 2D-image
19-NH4+Pinus sylvestris--391574 2D-image
22.8-NH4+Dictyostelium discoideum-non-activated NAD-GDH391585 2D-image
24.6-NH4+Psychrobacter sp.-NAD+-dependent enzyme391579 2D-image
25.6-NH4+Dictyostelium discoideum-activated NAD-GDH391585 2D-image
26-NH4+Achlya sp.--391541 2D-image
33-NH4+Streptomyces clavuligerus--391586 2D-image
33.3-NH4+Cucurbita pepo--391573 2D-image
37-NH4+Laccaria bicolor--391583 2D-image
40-NH4+Blastocladiella emersonii--391541 2D-image
49.4-NH4+Clostridium symbiosum-mutant D165N672020 2D-image
52.3-NH4+Bacillus subtilisP39633mutant E27F672661 2D-image
55.6-NH4+Bacillus subtilisP39633wild-type672661 2D-image
56.8-NH4+Bacillus subtilisP39633mutant Q144R672661 2D-image
60-NH4+Alicyclobacillus acidocaldarius--391578 2D-image
62.8-NH4+Clostridium symbiosum-wild-type672020 2D-image
96-NH4+Bacillus cereus-from double-reciprocal plots for concentrations between 5 mM and 200 mM391629 2D-image
144-NH4+Peptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
304-NH4+Clostridium symbiosum-chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH, Vmax: 1960 micromol/min/mg, pH 8.0, 25°C701137 2D-image
2.27-oxaloacetateBacillus subtilis-mutant M101S672660 2D-image
4.16-oxaloacetateBacillus subtilis-mutant G82K672660 2D-image
1349-L-glutamateClostridium symbiosum-chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH, Vmax: 121.9 micromol/min/mg, pH 8.0, 25°C701137 2D-image
additional information-additional informationRattus norvegicus-no significant changes in Km values between groups treated with alkalized extract from the tuber of Corydalis ternata or protopine and control groups673480-
additional information-additional informationClostridium symbiosum-wild-type Vmax: 23.71 (pH 7), 35.16 (pH 9)697928-
additional information-additional informationJanthinobacterium lividumA5LH94the enzyme shows positive cooperativity towards 2-oxoglutarate and NADH, and Michaelis-Menten type kinetics with ammonium chloride in the absence of catalytic activator L-aspartate. L-aspartate effect on enzyme kinetics, overview711526-
additional information-additional informationClostridium symbiosum-dissociation constants of wild-type and mutant enzymes for different coenzymes, overview711875-

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.012-2-oxoglutarateBacillus subtilis-mutant M101S672660 2D-image
0.013-2-oxoglutarateBacillus subtilis-mutant G82K672660 2D-image
20.3-2-oxoglutaratePeptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
342-2-oxoglutarateBacillus subtilisP39633wild-type672661 2D-image
344-2-oxoglutarateBacillus subtilis-wild-type672660 2D-image
344-2-oxoglutarateBacillus subtilisP39633mutant E27F672661 2D-image
435-2-oxoglutarateBacillus subtilisP39633mutant Q144R, 1.3 times higher than that of the wild-type672661 2D-image
6.7-glutamatePeptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
18.1-L-glutamateBacillus subtilisP39633wild-type672661 2D-image
6-NAD+Peptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
1.71-NADHPeptoniphilus asaccharolyticus-mutant enzyme E243R, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
10.6-NADHPeptoniphilus asaccharolyticus-mutant enzyme E243K, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
10.9-NADHPeptoniphilus asaccharolyticus-mutant enzyme W244S, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
16.4-NADHPeptoniphilus asaccharolyticus-mutant enzyme D245K, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
16.9-NADHPeptoniphilus asaccharolyticus-mutant enzyme E243D, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
31.3-NADHPeptoniphilus asaccharolyticus-wild type enzyme, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
31.4-NADHPeptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
0.16-NADP+Peptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
1.67-NADPHPeptoniphilus asaccharolyticus-mutant enzyme E243R, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
3-NADPHPeptoniphilus asaccharolyticus-mutant enzyme W244S, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
5.06-NADPHPeptoniphilus asaccharolyticus-mutant enzyme E243D, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
6-NADPHPeptoniphilus asaccharolyticus-mutant enzyme D245K, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
10-NADPHPeptoniphilus asaccharolyticus-wild type enzyme, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
12-NADPHPeptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
14.8-NADPHPeptoniphilus asaccharolyticus-mutant enzyme E243K, in 100 mM potassium phosphate buffer at pH 7 with 20 mM oxoglutarate and 100 mM ammonium chloride686673 2D-image
3.45-oxaloacetateBacillus subtilis-mutant G82K672660 2D-image
5.68-oxaloacetateBacillus subtilis-mutant M101S672660 2D-image
20.4-NH4+Peptoniphilus asaccharolyticus-pH 7, 25°C655641 2D-image
additional information-oxaloacetateBacillus subtilis-mutant M101S672660 2D-image

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
additional information-additional informationClostridium symbiosum-pseudo-first-order kinetic plots for inactivation of F238S GDH by DTNB, overview711875-

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.0064-3,3'-[(2-bromobenzene-1,4-diyl)di(E)ethene-2,1-diyl]bis(6-hydroxybenzoic acid)Bos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.0015-3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-oneBos taurusP00366pH 7.5698927 2D-image
0.0026-3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-oneTetrahymena-pH 7.5698927 2D-image
0.1-3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-oneEscherichia coli-value above 100, pH 7.5698927 2D-image
0.0158-ATP/GTP-competitive inhibitor of casein kinase-2Bos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127-
0.0012-Aurintricarboxylic acidBos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.0037-BH3I-2Bos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.0048-BithionolBos taurusP00366pH 7.5698927 2D-image
0.0055-BithionolBos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.0059-BithionolTetrahymena-pH 7.5698927 2D-image
0.017-BithionolEscherichia coli-pH 7.5698927 2D-image
0.0077-CalmidazoliumBos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.0017-DiethylstilbestrolBos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.0005-epicatechin-3-monogallateBos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.0005-epigallocatechin-3-monogallateBos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.05-erythrosin BBos taurus-IC50 above 0.05 mM, in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.08-Gallic acidBos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.0015-GW-5074Bos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.0017-HexachloropheneBos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.0019-HexachloropheneTetrahymena-pH 7.5698927 2D-image
0.0039-HexachloropheneBos taurusP00366pH 7.5698927 2D-image
0.012-HexachloropheneEscherichia coli-pH 7.5698927 2D-image
0.0328-metergolineBos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image
0.0138-suloctidilBos taurus-in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+685127 2D-image

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
0.0003-Clostridium symbiosum-mutant D165N overexpressed at 8°C672020
0.012-Bacillus subtilis-2-oxoglutarate, mutant M101K672660
0.014-Bacillus subtilis-2-oxoglutarate, mutant K80R672660
0.019-Bacillus subtilis-2-oxoglutarate, mutant G82R and M101S672660
0.026-Bacillus subtilis-2-oxoglutarate, mutant G82K672660
0.034-Clostridium symbiosum-mutant D165N overexpressed at 37°C672020
0.047-Clostridium symbiosum-mutant D165N overexpressed at 23°C672020
0.077-Entodinium caudatumQ9TVN3NADP-linked GDH activity673715
0.21-Bacillus subtilis-on L-aspartate, mutant M101S672660
0.29-Peptoniphilus asaccharolyticus-mutant enzyme W244S, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.0686673
0.32-Peptoniphilus asaccharolyticus-wild type enzyme, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.5686673
0.33-Peptoniphilus asaccharolyticus-mutant enzyme W244S, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.0; wild type enzyme, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 8.0686673
0.34-Peptoniphilus asaccharolyticus-mutant enzyme W244S, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.5686673
0.35-Rattus norvegicus-control group673480
0.39-Bacillus subtilis-on L-aspartate, mutant G82K672660
0.49-Clostridium symbiosum-chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH using NAD+701137
0.5-Peptoniphilus asaccharolyticus-mutant enzyme W244S, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 8.0686673
0.51-Peptoniphilus asaccharolyticus-mutant enzyme W244S, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.5686673
0.55-Entodinium caudatumQ9TVN3-673715
0.57-Rattus norvegicus-with protopine673480
0.62-Janthinobacterium lividumA5LH94recombinant enzyme from crude cell extract, at 25°C692832
0.73-Peptoniphilus asaccharolyticus-wild type enzyme, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.0686673
0.77-Entodinium caudatumQ9TVN3NAD-linked GDH activity673715
0.84-Rattus norvegicus-with alkalized extract from the tuber of Corydalis ternata673480
0.87-Peptoniphilus asaccharolyticus-mutant enzyme D245K, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.5686673
0.9-Peptoniphilus asaccharolyticus-mutant enzyme E243R, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.0686673
0.97-Entodinium caudatumQ9TVN3in the presence of antibiotics and ammonia673715
1.12-Peptoniphilus asaccharolyticus-mutant enzyme D245K, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.0686673
1.14-Peptoniphilus asaccharolyticus-mutant enzyme D245K, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 8.0686673
1.23-Peptoniphilus asaccharolyticus-wild type enzyme, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.5686673
1.32-Peptoniphilus asaccharolyticus-wild type enzyme, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.0686673
1.47-Peptoniphilus asaccharolyticus-mutant enzyme E243D, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.5; mutant enzyme E243D, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 8.0686673
1.53-Peptoniphilus asaccharolyticus-mutant enzyme D245K, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.0686673
1.8-Agaricus bisporus--391581
1.83-Peptoniphilus asaccharolyticus-mutant enzyme E243R, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.0686673
2.16-Peptoniphilus asaccharolyticus-mutant enzyme D245K, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.5686673
2.26-Peptoniphilus asaccharolyticus-mutant enzyme E243R, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.5686673
2.3-Peptoniphilus asaccharolyticus-mutant enzyme E243R, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.5686673
2.98-Peptoniphilus asaccharolyticus-mutant enzyme E243D, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.0686673
3-Peptoniphilus asaccharolyticus-mutant enzyme E243R, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.0686673
3.05-Peptoniphilus asaccharolyticus-mutant enzyme E243R, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.0686673
3.1-Janthinobacterium lividumA5LH94purified recombinant enzyme, at 25°C692832
3.27-Peptoniphilus asaccharolyticus-mutant enzyme E243K, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.0686673
3.41-Peptoniphilus asaccharolyticus-mutant enzyme E243R, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.5686673
3.51-Pyrobaculum islandicum-native enzyme671995
3.54-Pyrobaculum islandicum-recombinant, urea-activated enzyme671995
3.65-Pyrobaculum islandicum-recombinant, heat-activated enzyme671995
3.82-Peptoniphilus asaccharolyticus-mutant enzyme W244S, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.0686673
4.1-Peptoniphilus asaccharolyticus-mutant enzyme E243R, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 8.0686673
4.93-Peptoniphilus asaccharolyticus-mutant enzyme E243D, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.0686673
5-Peptoniphilus asaccharolyticus-mutant enzyme E243D, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.5686673
5.2-Peptoniphilus asaccharolyticus-mutant enzyme E243K, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.0686673
5.8-Peptoniphilus asaccharolyticus-mutant enzyme D245K, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.0686673
6.78-Peptoniphilus asaccharolyticus-mutant enzyme W244S, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.5686673
7.2-Peptoniphilus asaccharolyticus-mutant enzyme E243D, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.0686673
7.6-Pyrococcus sp.--391582
9.01-Peptoniphilus asaccharolyticus-mutant enzyme E243K, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.5686673
9.6-Peptoniphilus asaccharolyticus-mutant enzyme E243K, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.5686673
9.8-Peptoniphilus asaccharolyticus-wild type enzyme, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.0686673
11-Peptoniphilus asaccharolyticus-mutant enzyme E243R, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 8.0686673
12-Peptoniphilus asaccharolyticus-mutant enzyme E243R, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.5686673
12.5-Peptoniphilus asaccharolyticus-mutant enzyme D245K, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.5686673
15-Peptoniphilus asaccharolyticus-mutant enzyme E243D, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.5686673
17.6-Peptoniphilus asaccharolyticus-mutant enzyme E243K, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.0686673
19-Peptoniphilus asaccharolyticus-mutant enzyme E243K, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.0686673
19.7-Phaseolus vulgaris-in the absence of Hg and in the presence of 0.1 mM AlCl3673970
20-Peptoniphilus asaccharolyticus-mutant enzyme W244S, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.0686673
20.1-Peptoniphilus asaccharolyticus-mutant enzyme E243K, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 8.0686673
20.6-Peptoniphilus asaccharolyticus-wild type enzyme, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 6.5686673
21.2-Streptomyces clavuligerus--391586
25-Phaseolus vulgaris-in the presence of 0.001 mM Hg and in the presence of NH4NO3673970
25.3-Peptoniphilus asaccharolyticus-mutant enzyme E243K, with 0.1 mM NADPH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.5686673
26.7-Phaseolus vulgaris-in the presence of 0.001 mM Hg673970
30-Peptoniphilus asaccharolyticus-mutant enzyme D245K, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.0686673
31.4-Cucurbita pepo--391573
34-Peptoniphilus asaccharolyticus-mutant enzyme E243D, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.0686673
34.2-Phaseolus vulgaris-in the absence of Hg673970
38-Medicago sativa-GDH-I391569
50-Peptoniphilus asaccharolyticus-wild type enzyme, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.0686673
52.9-Phaseolus vulgaris-in the absence of Hg and in the presence of 5 mM sucrose673970
54-Pisum sativum--391546
54-Medicago sativa-GDH-II391569
54-Peptoniphilus asaccharolyticus-mutant enzyme E243K, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 8.0686673
54.6-Phaseolus vulgaris-in the presence of 0.01 mM Hg673970
56-Peptoniphilus asaccharolyticus-mutant enzyme E243K, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.5686673
56.5-Peptoniphilus asaccharolyticus-mutant enzyme W244S, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.5686673
58-Clostridium symbiosum-chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH using NADP+701137
58.6-Phaseolus vulgaris-in the absence of Hg and in the presence of 5 mM glutathione673970
59.4-Phaseolus vulgaris-in the absence of Hg and in the presence of 5 mM glutamine673970
62-Peptoniphilus asaccharolyticus-mutant enzyme W244S, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 8.0686673
64.5-Peptoniphilus asaccharolyticus--391551
65.8-Phaseolus vulgaris-in the absence of Hg and in the presence of NH4NO3673970
68-Peptoniphilus asaccharolyticus-mutant enzyme D245K, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.5686673
69.8-Emericella nidulans--391567
70-Thermus thermophilus--391584
70.94-Phaseolus vulgaris-in the presence of 0.1 mM Hg and in the presence of 5 mM glutathione673970
72-Phaseolus vulgaris-in the presence of 0.01 mM Hg and in the presence of NH4NO3673970
80-Alicyclobacillus acidocaldarius--391578
89.3-Haloferax mediterraneiQ977U6purified recombinant enzyme673495
90-Peptoniphilus asaccharolyticus-mutant enzyme E243D, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.5686673
101.8-Peptoniphilus asaccharolyticus-mutant enzyme D245K, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 8.0686673
102-Peptoniphilus asaccharolyticus-mutant enzyme E243D, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 8.0686673
104-Bos taurus-GDH II391591
104-Haloferax mediterraneiQ977U6purified native enzyme673495
119.5-Phaseolus vulgaris-in the presence of 0.1 mM Hg673970
146-Clostridium difficile--391575
155-Peptoniphilus asaccharolyticus-wild type enzyme, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 7.5686673
167-Bos taurus-GDH I391591
170.6-Phaseolus vulgaris-in the presence of 0.1 mM Hg and in the presence of 5 mM glutamine673970
171.4-Phaseolus vulgaris-in the presence of 0.1 mM Hg and in the presence of 0.1 mM AlCl3673970
174-Peptoniphilus asaccharolyticus-wild type enzyme, with 0.1 mM NADH, 20 mM oxoglutarate and 100 mM ammonium chloride at pH 8.0686673
183-Bacteroides fragilis--391577
200-Chlorella sorokiniana--391545
243.4-Phaseolus vulgaris-in the presence of 0.1 mM Hg and in the presence of NH4NO3673970
248-Psychrobacter sp.-NAD+-dependent enzyme391579
248-Psychrobacter sp.--655253
286.4-Bacillus cereus--391629
328.2-Phaseolus vulgaris-in the presence of 0.1 mM Hg and in the presence of 5 mM sucrose673970
401-Pisum sativum--391568
440-Bacillus subtilis-2-oxoglutarate, wild-type672660
441-Vitis vinifera--391561
540-Lemna minor--391568
822-Amphibacillus xylanus--391588
1092-Clostridium botulinum-above391566
additional information-Achlya sp., Apodachlya sp., Blastocladiella emersonii, Clostridium sp., Micrococcus aerogenes, Neurospora crassa, Peptoniphilus asaccharolyticus, Pisum sativum, Pythium debaryanum, Saccharomyces cerevisiae, Starkeya novella--391541
additional information-Neurospora crassa--391550, 391552
additional information-Vigna unguiculata--391553
additional information-Bacillus cereus--391555
additional information-Cyberlindnera jadinii--391570
additional information-Laccaria bicolor--391583
additional information-Streptomyces fradiae--391587
additional information-Salinibacter ruber--655623
additional information-Peptoniphilus asaccharolyticus--655641
additional information-Homo sapiens-glucose withdrawal stimulates GDH activity697113
additional information-Pseudomonas fluorescens-GDH activity is markedly increased in Pseudomonas fluorescens cultures exposed to menadione-containing media containing Arg, Glu and Pro. When NH4+ is utilized as the nitrogen source, both alpha-ketoglutarate dehydrogenase and GDH levels are diminished. These enzymatic profiles are reversed when control cells are incubated in menadione media698620

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
4-Thermus thermophilus-lowly activated anionic exchangers-epoxy-GDH is stable at pH 4 and 25°C697661
6.5-Janthinobacterium lividumA5LH94reductive amination assay at711526
7-Streptomyces clavuligerus--391586
7-Entodinium caudatumQ9TVN3-673715
7-Clostridium symbiosum-assay at, the wild-type enzyme displays negative NAD+ cooperativity at pH 7 and pH 9 values697928
7-Clostridium symbiosum-assay at711875
7.2-Cucurbita pepo--391573
7.37.5Dictyostelium discoideum-reductive amination391549
7.3-Bacillus subtilisP39633optimal for 2-oxoglutarate amination672661
7.47.5Symbiodinium microadriaticum-reductive amination391559
7.48.2Mytilus edulis-reductive amination391554
7.4-Laccaria bicolor-amination391583
7.5-Dictyostelium discoideum--391585
7.5-Bos taurusP00366assay at698927
7.5-Escherichia coli, Tetrahymena-assay at698927
7.7-Bacillus cereus-reductive amination of 2-oxoglutarate391629
7.7-Bacillus subtilisP39633optimal for L-glutamate deamination672661
7.8-Clostridium sp.-reductive amination391541
7.9-Blastocladiella emersonii-reductive amination391541
88.3Medicago sativa-reductive amination391569
88.5Phycomyces blakesleeanus-reductive amination391564
88.5Haloferax mediterraneiQ977U6-673495
8-Chlorella sorokiniana-reductive amination391545
8-Pisum sativum-reductive amination391546
8-Vitis vinifera-reductive amination391561
8-Bacteroides fragilis--391577
8-Thermus thermophilus-reductive amination391584
8-Salinibacter ruber--655623
8-Benjaminiella poitrasii-assay at696792
8-Aspergillus niger-assay at697654
8-Thermus thermophilus-assay at697661
8-Clostridium symbiosum-assay at701137
8.2-Apodachlya sp.-reductive amination391541
8.2-Pisum sativum-glutamate oxidation391541
8.2-Lupinus luteus-reductive amination391547
8.4-Agave americana-reductive amination391562
8.4-Alicyclobacillus acidocaldarius-forward reaction391578
8.59Synechocystis sp.-reductive amination391542
8.5-Pinus sylvestris--391574
8.5-Clostridium difficile--391575
8.8-Blastocladiella emersonii-glutamate oxidation391541
8.8-Lupinus luteus-oxidative deamination391547
8.8-Laccaria bicolor-deamination391583
8.8-Streptomyces fradiae-reductive amination391587
9-Apodachlya sp.-glutamate oxidation391541
9-Chlorella sorokiniana-oxidative deamination391545
9-Symbiodinium microadriaticum-oxidative deamination391559
9-Phycomyces blakesleeanus-oxidative deamination391564
9-Alicyclobacillus acidocaldarius-reverse reaction391578
9-Janthinobacterium lividumA5LH94in glycine-NaOH buffer at 40°C692832
9-Clostridium symbiosum-assay at, the wild-type enzyme displays negative NAD+ cooperativity at pH 7 and pH 9 values697928
9.2-Pisum sativum-oxidative deamination391546
9.2-Medicago sativa-oxidative deamination391569
9.2-Streptomyces fradiae-oxidative deamination391587
9.3-Vitis vinifera-oxidative deamination391561
9.4-Clostridium sp.-glutamate oxidation391541
9.4-Bacillus cereus-oxidative deamination of glutamate391629
9.510Synechocystis sp.-oxidative deamination391542
9.5-Mytilus edulis-oxidative deamination391554

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
68Peptoniphilus asaccharolyticus--686673
6.39.5Haloferax mediterraneiQ977U6-673495
6.98Bacillus subtilisP39633-672661
78.8Pisum sativum-about 50% of activity maximum at pH 7.0 and 8.8, reductive amination391546
7.510.5Cucurbita pepo--391573
7.59Agave americana-about 65% of activity maximum at pH 7.5 and 9.0, reductive amination391562
7.98.5Lupinus luteus-about 90% of activity maximum at pH 7.9 and 8.5, reductive amination391547
8.410.1Pisum sativum-50% of activity maximum at pH 8.4 and 10.1, oxidative deamination391546
8.49.2Lupinus luteus-about 90% of activity maximum at pH 8.4 and 9.2, oxidative deamination391547

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
20-Psychrobacter sp.-NAD+-dependent enzyme391579
20-Psychrobacter sp.--655253
25-Thermus thermophilus-lowly activated anionic exchangers-epoxy-GDH is stable at pH 4 and 25°C697661
25-Clostridium symbiosum-assay at697928
25-Bos taurus-assay at698313
25-Clostridium symbiosum-assay at701137
25-Janthinobacterium lividumA5LH94reductive amination assay at711526
25-Clostridium symbiosum-assay at711875
28-Aspergillus niger-assay at697654
3035Streptomyces fradiae--391587
30-Streptomyces clavuligerus--391586
38-Bacteroides fragilis--391577
4045Bacillus cereus--391555
40-Janthinobacterium lividumA5LH94in glycine-NaOH buffer at pH 9.0692832
5055Peptoniphilus asaccharolyticus--391551
5055Alicyclobacillus acidocaldarius--391578
60-Peptoniphilus asaccharolyticus--655641
60-Haloferax mediterraneiQ977U6-673495
66-Thermus thermophilus-assay at697661
8590Thermus thermophilus-deamination391584
90-Pyrobaculum islandicum--391589

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
837Clostridium symbiosum-decreasing temperature results in much lower enzyme activity672020
1043Psychrobacter sp.-10°C: about 45% of maximal activity, 43°C: about 75% of maximal activity655253
4080Peptoniphilus asaccharolyticus-40°C: about 50% of maximal activity, 80°C: about 40% of maximal activity655641

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
alimentary canalDoryteuthis pealeii--391558Manually annotated by BRENDA team
bloodHomo sapiens--695431Manually annotated by BRENDA team
brainBos taurus--391591Manually annotated by BRENDA team
brainRattus norvegicus--673480Manually annotated by BRENDA team
cotyledonCucurbita pepo--391573Manually annotated by BRENDA team
embryonic axisLupinus luteus--700651Manually annotated by BRENDA team
floretBrassica oleraceaQ50JE9GDH, in both amination and deamination activities, gradually increases in the floret portion as storage progresses672773Manually annotated by BRENDA team
flowerVitis vinifera-phloem companion cells657131Manually annotated by BRENDA team
glumeOryza sativa-specificly expressed700724Manually annotated by BRENDA team
heartDoryteuthis pealeii-systemic391558Manually annotated by BRENDA team
hepatopancreasMytilus edulis--391554Manually annotated by BRENDA team
leafVitis vinifera--391561Manually annotated by BRENDA team
leafAgave americana-medulla, cortex391562Manually annotated by BRENDA team
leafVitis vinifera-phloem companion cells657131Manually annotated by BRENDA team
leafTriticum aestivum-both GDH aminating activity and protein content are strongly induced in senescing flag leaves663075Manually annotated by BRENDA team
leafPhaseolus vulgaris--673970Manually annotated by BRENDA team
leafNicotiana tabacum--675147, 676596, 688076, 700719Manually annotated by BRENDA team
leafTriticum aestivum--675663, 675664, 701268Manually annotated by BRENDA team
leafNicotiana tabacumQ67C42, Q67C43; GDH activity is increased in homozygotes of sense lines and reduced in antisense line A63-H676690Manually annotated by BRENDA team
leafBrassica napus--689656Manually annotated by BRENDA team
leafSolanum lycopersicum--694766Manually annotated by BRENDA team
liverBos taurus--698313Manually annotated by BRENDA team
muscleArenicola marina--391557Manually annotated by BRENDA team
myceliumEmericella nidulans--391567Manually annotated by BRENDA team
needlePinus sylvestris--391574Manually annotated by BRENDA team
noduleLupinus luteus--391543, 391547Manually annotated by BRENDA team
pancreatic beta cellMus musculus--698996Manually annotated by BRENDA team
phloemTriticum aestivum--663075Manually annotated by BRENDA team
phloem companion cellLupinus luteusQ5BU42, Q5BU43, Q5BU44, Q5QDM6; ; ; 688640Manually annotated by BRENDA team
rootMedicago sativa--391569Manually annotated by BRENDA team
rootOryza sativaQ852M0GDH detected in the region of the apical meristem and cortical cells in the tip region and elongation zone of the roots in both untreated and NH4Cl-treated plants, GDH3 barely detectable in leaf blades, leaf sheaths, spikelets and roots670544Manually annotated by BRENDA team
rootTriticum aestivum--671178Manually annotated by BRENDA team
rootNicotiana tabacum--676630, 694766Manually annotated by BRENDA team
rootNicotiana tabacumQ67C42, Q67C43GDH activity is increased in homozygotes of sense lines and reduced in antisense line A63-H; in A63-H lines the alpha-subunit level is unaffected as compared to controls676690Manually annotated by BRENDA team
seedPisum sativum--391568Manually annotated by BRENDA team
seedMedicago sativa--391569Manually annotated by BRENDA team
seedLupinus luteusQ5BU42, Q5BU43, Q5BU44, Q5QDM6; ; ; 688640Manually annotated by BRENDA team
seedlingVigna unguiculata--391553Manually annotated by BRENDA team
seedlingZea mays--391572Manually annotated by BRENDA team
seedlingTriticum aestivum--671178, 675664Manually annotated by BRENDA team
seedlingNicotiana tabacumQ67C42, Q67C43; 676690Manually annotated by BRENDA team
SF-188 cellHomo sapiens--697113Manually annotated by BRENDA team
shootZea mays--391572Manually annotated by BRENDA team
shootTriticum aestivum--671178Manually annotated by BRENDA team
shootNicotiana tabacum--688076Manually annotated by BRENDA team
stamenOryza sativa-specificly expressed700724Manually annotated by BRENDA team
stemPisum sativum--391546Manually annotated by BRENDA team
mantle muscleDoryteuthis pealeii--391558Manually annotated by BRENDA team
additional informationTriticum aestivum-absent from mesophyll section663075Manually annotated by BRENDA team
additional informationBrassica oleraceaQ50JE9branchlet, GDH, in both amination and deamination activities, decreases in the branchlets as storage progresses672773Manually annotated by BRENDA team
additional informationOryza sativa-ubiquitously expressed in various tissues700724Manually annotated by BRENDA team

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
cytoplasmSalinibacter ruber--5737655623Manually annotated by BRENDA team
cytoplasmChlorocebus sabaeusB5AAK2-5737689705Manually annotated by BRENDA team
cytoplasmGorilla gorillaB5AAK3-5737689705Manually annotated by BRENDA team
cytoplasmHomo sapiens-GLUD15737689705Manually annotated by BRENDA team
cytoplasmPan troglodytesB5AAJ9-5737689705Manually annotated by BRENDA team
cytoplasmPongo pygmaeusB5AAK0-5737689705Manually annotated by BRENDA team
cytoplasmSymphalangus syndactylusB5AAK1-5737689705Manually annotated by BRENDA team
cytoplasmic membranePseudomonas aeruginosa-bound to-661800Manually annotated by BRENDA team
cytosolEmericella nidulans--5829391567Manually annotated by BRENDA team
cytosolTriticum aestivum-some labelling in the cytosol of the phloem companion cells of senescing flag leaves5829663075Manually annotated by BRENDA team
membraneBacteroides fragilis--16020391577Manually annotated by BRENDA team
membranePseudomonas aeruginosa-bound to cytoplasmic membrane16020661800Manually annotated by BRENDA team
mitochondrionPisum sativum--5739391546Manually annotated by BRENDA team
mitochondrionDoryteuthis pealeii--5739391558Manually annotated by BRENDA team
mitochondrionVitis vinifera--5739391561Manually annotated by BRENDA team
mitochondrionZea mays--5739391572Manually annotated by BRENDA team
mitochondrionVitis vinifera-preferentially localized in the mitochondria of phloem companion cells in both leaves and flowers5739657131Manually annotated by BRENDA team
mitochondrionTriticum aestivum-in mature flag leaves, GDH is localized in the mitochondria of the phloem companion cells, increases in senescensing flag leaves5739663075Manually annotated by BRENDA team
mitochondrionNicotiana tabacumQ67C42, Q67C43; 5739676690Manually annotated by BRENDA team
mitochondrionBos taurus--5739685127Manually annotated by BRENDA team
mitochondrionArabidopsis thaliana, Nicotiana plumbaginifolia, Nicotiana tabacum--5739688076Manually annotated by BRENDA team
mitochondrionLupinus luteusQ5BU42, Q5BU43, Q5BU44, Q5QDM6; ; ; 5739688640Manually annotated by BRENDA team
mitochondrionChlorocebus sabaeusB5AAK2-5739689705Manually annotated by BRENDA team
mitochondrionGorilla gorillaB5AAK3-5739689705Manually annotated by BRENDA team
mitochondrionHomo sapiens-GLUD2 is specifically targeted to mitochondria, whereas GLUD1 is localized in mitochondria and cytoplasm5739689705Manually annotated by BRENDA team
mitochondrionPan troglodytesB5AAJ9-5739689705Manually annotated by BRENDA team
mitochondrionPongo pygmaeusB5AAK0-5739689705Manually annotated by BRENDA team
mitochondrionSymphalangus syndactylusB5AAK1-5739689705Manually annotated by BRENDA team
mitochondrionMus musculus--5739698996Manually annotated by BRENDA team
mitochondrionLupinus luteus--5739700651Manually annotated by BRENDA team
multivesicular bodyVitis vinifera-within the flower receptacle, significant amounts of enzyme5771657131Manually annotated by BRENDA team

PDBSCOPCATHORGANISM
3k8z, downloadSCOP (3k8z)CATH (3k8z)Bacillus subtilis (strain 168)
3k92, downloadSCOP (3k92)CATH (3k92)Bacillus subtilis (strain 168)
1aup, downloadSCOP (1aup)CATH (1aup)Clostridium symbiosum
1bgv, downloadSCOP (1bgv)CATH (1bgv)Clostridium symbiosum
1hrd, downloadSCOP (1hrd)CATH (1hrd)Clostridium symbiosum
1k89, downloadSCOP (1k89)CATH (1k89)Clostridium symbiosum
2yfh, downloadSCOP (2yfh)CATH (2yfh)Escherichia coli (strain K12)
2yfq, downloadSCOP (2yfq)CATH (2yfq)Peptostreptococcus asaccharolyticus
1v9l, downloadSCOP (1v9l)CATH (1v9l)Pyrobaculum islandicum
1euz, downloadSCOP (1euz)CATH (1euz)Thermococcus profundus

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
45000-Bacillus subtilis-SDS-PAGE689048
46000-Bacillus subtilis-SDS-PAGE672660
48000-Entodinium caudatumQ9TVN3sequence analysis673715
87000-Clostridium symbiosum-F187D mutant, gel filtration391576
98000-Phycomyces blakesleeanus-gel filtration391564
110000130000Starkeya novella-sucrose density gradient sedimentation391541
165000175000Bacillus cereus-GDHA, gel filtration391555
180000-Chlorella sorokiniana-gel filtration391545
210000250000Blastocladiella emersonii-sucrose density gradient sedimentation391541
210000-Pisum sativum-gel filtration391541
220000-Pyrobaculum islandicum-gel filtration391589
225000-Achlya sp., Pythium debaryanum-sucrose density gradient sedimentation391541
226000-Salinibacter ruber-gel filtration655623
230000-Lemna minor-gel filtration391568
230000-Pisum sativum-sedimentation equilibrium analysis391568
240000250000Bacillus cereus-GDH B, gel filtration391555
250000-Sporosarcina ureae-gel filtration391580
250800-Clostridium botulinum-gel filtration391566
252000-Vitis vinifera-gel filtration391561
260000-Amphibacillus xylanus-gel filtration391588
266000-Peptoniphilus asaccharolyticus-gel filtration391551, 391571
268000282000Clostridium sp.-sedimentation equilibrium391541
270000-Peptoniphilus asaccharolyticus-gel filtration391541
270000-Lupinus luteus-gel filtration391547
270000-Bacillus cereus-gel filtration391629
270000-Bacillus subtilisP39633gel filtration672661
280000-Pyrobaculum islandicum-recombinant enzyme, gel filtration671995
284000-Pyrococcus sp.-gel filtration391582
289000-Thermus thermophilus-gel filtration391584
290000-Alicyclobacillus acidocaldarius-gel filtration391578
290000-Haloferax mediterraneiQ977U6recombinant NAD-GDH673495
295000-Synechocystis sp.-gel filtration391542
299000-Pyrobaculum islandicum-recombinant, heat-activated enzyme, gel filtration671995
300000-Clostridium difficile-gel filtration391575
300000-Psychrobacter sp.-NAD+-dependent enzyme, gel filtration391579
300000-Psychrobacter sp.-gel filtration655253
310000-Neurospora crassa-gel filtration391556
310000-Haloferax mediterraneiQ977U6wild-type NAD-GDH673495
330000-Neurospora crassa-amino acid data391550
330000-Bos taurus-non-denaturing PAGE391591
337000-Pyrobaculum islandicum-recombinant, urea-activated enzyme, gel filtration671995
350000390000Clostridium sp.-gel filtration391541
356000-Dictyostelium discoideum-gel filtration391549
380000-Crithidia fasciculata-gel filtration391544
460000-Cyberlindnera jadinii-sedimentation equilibrium391570
470000-Laccaria bicolor-gel filtration391583
474000-Agaricus bisporus-gel filtration391581
480000-Neurospora crassa-sedimentation equilibrium analysis391552
670000-Emericella nidulans-gel filtration391567
1100000-Streptomyces clavuligerus-gel filtration391586

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
?Haloferax mediterraneiQ977U6x * 54000, SDS-PAGE, x * 47950, sequence analysis673495
dimerPhycomyces blakesleeanus-2 * 54000, SDS-PAGE391564
dimerClostridium symbiosum-F187D mutant, 2 * 47000391576
dimerPsychrobacter sp.-NAD+-dependent enzyme, 2 * 160000, SDS-PAGE391579
dimerPsychrobacter sp.-2 * 160000, SDS-PAGE655253
hexamerSynechocystis sp.-6 * 48500, SDS-PAGE391542
hexamerLupinus luteus-6 * 45000, SDS-PAGE391547
hexamerDictyostelium discoideum-6 * 54000, SDS-PAGE391549
hexamerNeurospora crassa-6 * 51500, SDS-PAGE391550
hexamerVitis vinifera-6 * 42500, SDS-PAGE391561
hexamerClostridium botulinum-6 * 42500, SDS-PAGE391566
hexamerClostridium difficile-6 * 45000, SDS-PAGE391575
hexamerAlicyclobacillus acidocaldarius-6 * 48000, SDS-PAGE391578
hexamerSporosarcina ureae-6 * 42000, SDS-PAGE391580
hexamerPyrococcus sp.-6 * 43000, SDS-PAGE391582
hexamerThermus thermophilus-6 * 48000, SDS-PAGE391584
hexamerStreptomyces clavuligerus-6 * 183000, SDS-PAGE391586
hexamerAmphibacillus xylanus-6 * 45000, SDS-PAGE391588
hexamerPyrobaculum islandicum-6 * 36000, SDS-PAGE391589
hexamerBos taurus-6 * 57500, SDS-PAGE391591
hexamerSalinibacter ruber-6 * 40000, SDS-PAGE655623
hexamerPyrobaculum islandicum-6 * 47000, SDS-PAGE671995
hexamerBacillus subtilisP396336 * 46000, SDS-PAGE, 6 * 46587, MALDI-MS, 6 * 46553, sequence analysis672661
hexamerClostridium symbiosum-x-ray crystallography686665
hexamerArabidopsis thaliana, Nicotiana plumbaginifolia, Nicotiana tabacum--688076
hexamerClostridium symbiosum-native PAGE701137
hexamer or pentamerPeptoniphilus asaccharolyticus-5 * or 6 * 49000, SDS-PAGE391571
homohexamerJanthinobacterium lividumA5LH946 * 169360, deduced from amino acid sequence; 6 * 170000, SDS-PAGE692832
tetramerChlorella sorokiniana-4 * 45000, SDS-PAGE391545
tetramerNeurospora crassa-4 * 116000, sedimentation equilibrium analysis after treatment with 6 M guanidine HCl and 0.5% mercaptoethanol391552
tetramerLemna minor, Pisum sativum-4 * 58500, SDS-PAGE391568
tetramerCyberlindnera jadinii-4 * 116000, SDS-PAGE391570
tetramerAgaricus bisporus-4 * 116000, SDS-PAGE391581
tetramerLaccaria bicolor-4 * 116000, SDS-PAGE391583
homotrimerThermus thermophilus-method not specified697661
additional informationSynechocystis sp.--391542

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
nitrosylationBos taurus-results reveal both hemin-H2O2-NO2 and 3-morpholinosydnonimine hydrochloride can cause inactivation of GDH through protein oxidation and tyrosine nitration, the impact of the effect of protein oxidation (not thiol oxidation) on enzyme activity is stronger than that of protein tyrosine nitration. Mass spectrometric analysis indicate that nitrated tyrosine residues by hemin-H2O2-NO2 are Tyr262 and Tyr471 while by 3-morpholinosydnonimine hydrochloride are Tyr401 and Tyr493698313

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
co-crystallization of GDH with hexachlorophene and 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one is performed using the hanging drop, vapor-diffusion method at room temperature. In both cases, the drops are formed using a 1:1 mix of protein and reservoir solutionsBos taurusP00366698927
purified recombinant wild-type and SeMet-labeled GDHs, hanging drop vapour diffusion method, at 20°C, protein in 10 mM Tris-HCl, pH 7.0, mixing of 0.002 ml of protein solution with 0.001 ml of reservoir solution containing 2.0 M ammonium sulfate, 0.1 M sodium cacodylate, pH 6.5, 200 mM NaCl, and equilibration with 0.5 ml reservoir solution, X-ray diffraction structure determination and analysis at 3.5 A resolutionPeptoniphilus asaccharolyticusP28997710758
3D structure determined by X-ray diffraction method, refined at a resolution of 2.9 A with a crystallographic R-factor of 19.9%. Crystals belonging to the space group P2(1)2(1)2(1) are grown in hanging drops in which 0.005 ml NAD+ is equilibrated against a reservoir containing 24% v/v polyethylene glycol monomethylether 550, 100 mM NaCl and 100 mM Tris-HClPyrobaculum islandicum-656554
-Thermotoga maritima-391590

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
4-Mytilus edulis-15 min, 30°C, inactivation391554
6.57.2Mytilus edulis-15 min, 30°C, stable391554
7-Clostridium symbiosum-the wild type enzyme shows pH-dependent inactivation and conformational change and loses 91% of its activity over a few min on transfer from pH 7.0 to pH 8.8686665
8-Mytilus edulis-15 min, 30°C, inactivation391554

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
04Sporosarcina ureae-complete inactivation391580
0-Bacillus cereus--391629
2025Bacillus cereus-no activity in cell extracts prepared at 0 to 4°C, high activities between 20°C and 25°C, 70% activity is retained after 2 h at 0°C in the presence of 20% glycerol391629
30-Psychrobacter sp.-about 45% loss of activity after 15 min, about 60% loss of activity after 30 min655253
4050Janthinobacterium lividumA5LH94the enzyme is stable for 10 min at temperatures up to 40°C but is completely inactivated by incubation for 10 min at 50°C692832
40-Psychrobacter sp.-about 60% loss of activity after 5 min, about 80% loss of activity after 15 min655253
41-Bacillus subtilisP3963350% of its activity remains after incubation of the wild-type enzyme for 20 min672661
50-Neurospora crassa-6 min, complete loss of activity391552
50-Clostridium symbiosum-the wild-type GDH retains only approximately 48% of starting activity after incubation at 50°C for 30 min in potassium phosphate (pH 7.0), mutant enzymes W243F and W449F show slightly enhanced stability, retaining approximately 5% more activity over the 30 min period, mutants W310F and W393F show greater stabilization retaining 78% and 82% of their activities, respectively, W64F retains only 37% activity after 30 min686665
55-Symbiodinium microadriaticum-half-life: 60 min391559
65-Synechocystis sp.-20 min, 50% loss of activity391542
70-Clostridium botulinum-10 min, 40% loss of activity391566
70-Peptoniphilus asaccharolyticus-24 h, stable655641
72-Peptoniphilus asaccharolyticus-half-life: 410 min655641
75-Sporosarcina ureae-15 min, complete inactivation391580
78-Peptoniphilus asaccharolyticus-half-life: 50 min655641
80-Peptoniphilus asaccharolyticus-10 min, complete inactivation391551
82-Peptoniphilus asaccharolyticus-half-life: 30 min655641
85-Amphibacillus xylanus-120 min, 50% activity loss391588
100-Pyrobaculum islandicum-no loss of activity after 2 h391589

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
extremely unstable at 0°C to 4°C due to the dissociation of the holoenzyme into catalytically inactive subunitsBacillus cereus-391629
the enzyme resists proteolysis by trypsin, chymotrypsin or endoproteinase Glu-C at 25°C. Above 30°C the enzyme became cleavable by chymotrypsin, at a single site. Proteolysis is accompanied by the loss of enzyme activity. Proteolysis is prevented by either of the substrates 2-oxoglutarate or L-glutamate but not by the coenzymes NAD+ or NADHClostridium symbiosum-656115
the enzyme resists proteolysis by trypsin, chymotrypsin or endoproteinase Glu-C at 25°C. Above 30°C the enzyme becomes cleavable by chymotrypsin, at a single site. Proteolysis is accompanied by the loss of enzyme activity. Proteolysis is prevented by either of the substrates 2-oxoglutarate or L-glutamate but not by the coenzymes NAD+ or NADHClostridium symbiosum-656115
guanidine hydrochloride, 1.0 M, complete denaturationEmericella nidulans-391567
ammonium sulfate improves stabilityLaccaria bicolor-391583
2-oxoglutarate stabilizesMytilus edulis-391554
ADP stabilizesMytilus edulis-391554
NADH stabilizesMytilus edulis-391554
DTT stabilizesNeurospora crassa-391552
isophthalate stabilizesNeurospora crassa-391552
NaCl, 0.1 M, stabilizesNeurospora crassa-391550
potassium phosphate buffer, high concentration, stabilizesNeurospora crassa-391556
presence of sulfhydryl groups in the environment stabilizesNeurospora crassa-391556
strong dependence on high salt concentrations for stabilitySalinibacter ruber-655623
repeated freezing and thawing: loss of activityVigna unguiculata-391553

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
4-5°C, 0.066 M phosphate buffer, pH 7.4 or 0.01 M arginine buffer, pH 9.5, 20 days, stableBacillus cereus-391555
-20°C, loss of activity overnightClostridium botulinum-391566
4°C, 3 days, stableClostridium botulinum-391566
-15°C, 50 mM Tris-HCl, pH 7.5, 0.1 M KCl, stable for several monthsClostridium difficile-391575
-20°CClostridium symbiosum-672020
-20°C, up to 1 year, stableLupinus luteus-391547
-20°C, gradual loss of activityNeurospora crassa-391552
4°C, suspension of 50% saturated ammonium sulfate, 0.1 mM DTT, 25 mM glutamate, stable for monthsNeurospora crassa-391552
4°C, more than 90% of original activity retained after 20 daysSymbiodinium microadriaticum-391559
-20°C, several monthsVigna unguiculata-391553
-5°C, 20% loss of activity after 3 monthsVigna unguiculata-391553

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-Acanthamoeba culbertsoni-391560
-Agaricus bisporus-391581
-Alicyclobacillus acidocaldarius-391578
-Amphibacillus xylanus-391588
DEAE-Sephacel column chromatographyAspergillus niger-686726
NAD-GDH is best obtained from proline grown Aspergillus niger myceliaAspergillus niger-697654
18-22°C, 20% glycerol, heat treatment, ammonium sulfate, gel filtration, ion-exchange chromatographyBacillus cereus-391629
2 isoenzymes GDHA, GDHBBacillus cereus-391555
Ni2+ HiTrap chelating column chromatographyBacillus subtilis-689048
to homogeneityBacillus subtilis-672660
to homogeneity, about 39foldBacillus subtilisP39633672661
overexpression of GDHB in Escherichia coliBacteroides fragilis-391577
GDH I and IIBos taurus-391591
DEAE-cellulose column chromatography and Super-Q Toyopearl column chromatographyBrassica napus-689656
-Chlorella sorokiniana-391545
-Clostridium botulinum-391566
overexpression in Escherichia coliClostridium difficile-391575
gel filtrationClostridium symbiosum-673612
overexpression of F187D mutant in Escherichia coliClostridium symbiosum-391576
Remazol-Red column chromatographyClostridium symbiosum-686665
to homogeneityClostridium symbiosum-672020
using dye-affintiy chromatography and anion-exchange chromatographyClostridium symbiosum-701137
-Crithidia fasciculata-391544
-Cucurbita pepo-391573
-Cyberlindnera jadinii-391570
-Dictyostelium discoideum-391549
activated and non-activated formDictyostelium discoideum-391585
-Doryteuthis pealeii-391558
-Emericella nidulans-391567
gel filtration, native enzyme 232fold purified, recombinant enzyme 5.4fold purifiedHaloferax mediterraneiQ977U6673495
to homogeneityHomo sapiens-673480
DEAE-Toyopearl column chromatography, butyl-Toyopearl column chromatography, and Superdex 200 gel filtrationJanthinobacterium lividumA5LH94692832
recombinant enzyme from Escherichia coli TOP10 cells by hydrophobic interaction chromatographyJanthinobacterium lividumA5LH94711526
-Laccaria bicolor-391583
-Lemna minor-391568
4 isoenzymesLupinus luteus-391547
2 isoenzymes: GDH-I and GDH-IIMedicago sativa-391569
-Mytilus edulis-391554
-Neurospora crassa-391550, 391552, 391556
by sonication and centrifugationOryza sativaQ852M0670544
-Peptoniphilus asaccharolyticus-391551, 391571
Q sepharose column chromatographyPeptoniphilus asaccharolyticus-686673
recombinant enzymePeptoniphilus asaccharolyticus-655641
-Phycomyces blakesleeanus-391564
-Pinus sylvestris-391574
-Pisum sativum-391546, 391568
-Psychrobacter sp.-655253
NAD+-dependent and NADP+-dependent GDHPsychrobacter sp.-391579
-Pyrobaculum islandicum-391589, 671995
overexpression in Escherichia coliPyrococcus sp.-391582
-Salinibacter ruber-655623
-Sporosarcina ureae-391580
-Streptomyces clavuligerus-391586
-Streptomyces fradiae-391587
-Symbiodinium microadriaticum-391559
overexpression of mutants in Escherichia coliThermotoga maritima-391590
-Thermus thermophilus-391584
GDH is readily adsorbed on highly activated anionic exchangers (HAAE), but hardly adsorbed on lowly activated supports (LAAE) or on highly activated epoxy supports. Using amino-epoxy supports, GDH immobilizes on HAAE-epoxy and more slowly on LAAE-epoxy supports. Both immobilized biocatalysts are incubated at pH 10 for different times to increase the multipoint covalent attachment. Lowly activated anionic exchangers-epoxy-GDH is stable at pH 4 and 25°C, the enzyme stability does not depend on the enzyme concentration and does not release any subunit to the supernatant, in opposition to the results obtained using HAAE-epoxy supportsThermus thermophilus-697661
-Vigna unguiculata-391553
7 isoenzymesVitis vinifera-391561

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
expressed in Escherichia coli BL21(DE3)/pLysS cellsBacillus subtilis-689048
expression in Escherichia coliBacillus subtilis-672660
expression in Escherichia coli MV1184Bacillus subtilisP39633672661
ligated to plasmid pT7Blue vector and cloned into Escherichia coli DH5aBrassica oleraceaQ50JE9672773
expressed in Escherichia coliClostridium symbiosum-686665, 697928, 701137
expression in Escherichia coli TG1Clostridium symbiosum-673612
expression in Escherichia coli TG1 cellsClostridium symbiosum-672020
expressed in Escherichia coli XLOLREntodinium caudatumQ9TVN3673715
expression in Escherichia coliHalobacterium salinarumP29051655606
ligated to NdeI/BamHI digested pET3a, expression in Escherichia coli BL21 (DE3)Haloferax mediterraneiQ977U6673495
expression of isoenzymes in Escherichia coli as soluble proteinsHomo sapiens-673480
expressed in Escherichia coli Top10 cellsJanthinobacterium lividumA5LH94692832
recombinant expression in Escherichia coli TOP10 cellsJanthinobacterium lividumA5LH94711526
gene msmeg_4699, semi-quantitative real-time PCR expression analysisMycobacterium smegmatisA0R1C2711601
tobacco transformed with either an antisense or sense copy of a beta-subunit gene of tomato GDH, transgenic plants recover with between 0.5- and 34-times normal leaf GDH activity; tobacco transformed with either an antisense or sense copy of a beta-subunit gene of tomato GDH, transgenic plants recover with between 0.5- and 34-times normal leaf GDH activityNicotiana tabacumQ67C42, Q67C43676690
expression in Escherichia coli BL21 cellsOryza sativaQ852M0670544
expressed in Escherichia coli strain TG1Peptoniphilus asaccharolyticus-686673
expression of wild-type GDH in Escherichia coli strain BL21(DE3), and of the SeMet-labeled enzyme in Escherichia coli strain B834 (DE3)Peptoniphilus asaccharolyticusP28997710758
overexpression in Escherichia coliPeptoniphilus asaccharolyticus-655641
expressed in Escherichia coli (DE3)-codon plus-RIL cellsPyrobaculum islandicum-671995
expressed in Solanum lycopersicum line S77-HSolanum lycopersicum-694766
overexpressed in Escherichia coliThermus thermophilus-697661

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
enzyme expression is upregulated under N2-starvation, overviewMycobacterium smegmatisA0R1C2711601
under nitrogen- and phosphorus-deficient conditions, respectively: OsGDH2 expression is largely reduced by both nitrogen- and phosphorus-deprivation after 1 hOryza sativa-700724
under nitrogen- and phosphorus-deficient conditions, respectively: In shoots, OsGDH2 is dramatically induced after nitorgen-deprivation for 1 day, with 5.4fold increase, respectively. Its expression increases greatly after 7 days of phosphorus-deprivation; under nitrogen- and phosphorus-deficient conditions, respectively: In shoots, OsGDH3 is dramatically induced after nitorgen-deprivation for 1 day, with 9.7fold increase, respectively. OsGDH3 expression is also up-regulated by 3.1fold after phosphorus-deprivation for 7 days. OsGDH3 transcript is undetectable under the normal conditions in roots, and increases by 7.6fold after phosphorus-deprivation for 1 dayOryza sativa-700724

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
E27FBacillus subtilisP39633improved thermostability as compared to wild-type672661
E27KBacillus subtilisP39633slightly improved thermostability as compared to wild-type672661
E27VBacillus subtilisP39633slightly improved thermostability as compared to wild-type672661
G255ABacillus subtilisP39633no significant thermostability672661
G82KBacillus subtilis-dramatically switches to increased specificity for oxaloacetate, 280fold higher than those for 2-oxoglutarate672660
G82RBacillus subtilis-specific activity not drastically altered compared to the wild-type672660
K80RBacillus subtilis-specific activity not drastically altered compared to the wild-type672660
M101KBacillus subtilis-specific activity not drastically altered compared to the wild-type672660
M101SBacillus subtilis-dramatically switches to increased specificity for oxaloacetate, 495fold higher than those for 2-oxoglutarate672660
Q144CBacillus subtilisP39633improved thermostability as compared to wild-type672661
Q144DBacillus subtilisP39633slightly improved thermostability as compared to wild-type672661
Q144KBacillus subtilisP39633no improved thermostability as compared to wild-type672661
Q144RBacillus subtilisP39633highly improved thermostability as compared to wild-type672661
W100RBacillus subtilisP39633no significant thermostability672661
D165NClostridium symbiosum-residual 2% of wild-type activity when purified after expression in Escherichia coli at 37°C, cells induced at 8°C are 1000fold less active than that produced at 37°C, spontaneous deamidation, which depends on the residual catalytic machinery of the mutated GDH active site672020
D165N/K125AClostridium symbiosum-correctly folded, no significant deamidation673612
D263KClostridium symbiosum-site-directed mutagenesis, the mutant shows altered binding kinetics for cofactors compared to the wild-type enzyme, the mutant shows increased dissociation constants for NAD+, NADH, and NADPH, but decreased for DTNB leading to inactivation by the inhibitor711875
F187DClostridium symbiosum-dimeric form of enzyme391576
F238SClostridium symbiosum-site-directed mutagenesis, the mutant shows altered binding kinetics for cofactors compared to the wild-type enzyme, the mutant shows increased dissociation constants711875
P262SClostridium symbiosum-site-directed mutagenesis, the mutant shows altered binding kinetics for cofactors compared to the wild-type enzyme, the mutant shows increased dissociation constants711875
W243FClostridium symbiosum-decreased activity compared to the wild type enzyme, more thermostable than the wild type enzyme686665
W310FClostridium symbiosum-more thermostable than the wild type enzyme686665
W393FClostridium symbiosum-increased activity compared to the wild type enzyme, more thermostable than the wild type enzyme686665
W449FClostridium symbiosum-decreased activity compared to the wild type enzyme, more thermostable than the wild type enzyme686665
W64FClostridium symbiosum-65% wild type enzyme activity, less thermostable than the wild type enzyme686665
Y187MHomo sapiens-no further stimulation of the mutated GDH isoenzymes by ADP in contrast to the wild-type673480
D245KPeptoniphilus asaccharolyticus-the mutation shows reduced activity and 36.4fold discrimination against NADPH compared to NADH686673
E243DPeptoniphilus asaccharolyticus-the mutation shows reduced activity and 130fold discrimination against NADPH compared to NADH686673
E243KPeptoniphilus asaccharolyticus-the mutation shows reduced activity and almost no discrimination against NADPH compared to NADH686673
E243RPeptoniphilus asaccharolyticus-the mutation shows reduced activity and almost no discrimination against NADPH compared to NADH686673
W244SPeptoniphilus asaccharolyticus-the mutation shows reduced activity and 205fold discrimination against NADPH compared to NADH686673
molecular biologyPseudomonas fluorescens-alpha-ketoglutarate dehydrogenase and GDH play a critical role in modulating alpha-ketoglutarate homeostasis698620
G376KThermotoga maritima-faster thermal inactivation, higher specific activity at 58°C391590
N97DThermotoga maritima-faster thermal inactivation391590
N97D/G376KThermotoga maritima-faster thermal inactivation, higher specific activity at 58°C391590
F238S/P262SClostridium symbiosum-site-directed mutagenesis, the mutant shows altered binding kinetics for cofactors compared to the wild-type enzyme, the mutant shows increased dissociation constants711875
additional informationClostridium symbiosum-an active chimera (CEC) consisting of the substrate-binding domain (domain I) of CsGDH and the coenzyme-binding domain (domain II) of Escherichia coli GDH is generated. Kinetic constants of chimeric protein: Km values for substrates L-glutamate, 2-oxoglutarate, NH4Cl highly increased compared to wild-type, Vmax values also highly increased compared to wild-type. The CEC chimera, like Escherichia coli GDH, has a marked preference for NADP(H) as coenzyme. selectivity for the phosphorylated coenzyme does indeed reside solely in domain II. Positive cooperativity toward L-glutamate, characteristic of wild-type CsGDH, retains with domain I. Although glutamate cooperativity occurs only at higher pH values in the wild-tpye CsGDH, the chimeric protein shows it over the full pH range explored. The chimera is capable of catalyzing severalfold higher reaction rates (Vmax) in both directions than either of the parent enzymes from which it is constructed701137

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
after 10fold dilution of the enzyme denatured with 3 M guanidine hydrochloride, the enzyme does not recover its activity, whereas after dialysis, the protein recovers 10% of the original activity valueThermus thermophilus-656633

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
biotechnologyBenjaminiella poitrasii-a strategy to control flocculation is investigated using dimorphic yeast, Benjaminiella poitrasii as a model. Parent form of this yeast (Y) exhibit faster flocculation (11.1 min) than the monomorphic yeast form mutant Y-5 (12.6 min). Flocculation of both Y and Y-5 can be altered by supplementing either substrates or inhibitor of NAD-glutamate dehydrogenase (NAD-GDH) in the growth media. The rate of flocculation is promoted by alpha-ketoglutarate or isophthalic acid and decelerated by glutamate with a statistically significant inverse correlation to corresponding NAD-GDH levels. This opens up new possibilities of using NAD-GDH modulating agents to control flocculation in fermentations for easier downstream processing; the rate of flocculation is promoted by a-ketoglutarate or isophthalic acid and decelerated by glutamate with a statistically significant inverse correlation to corresponding NAD-GDH levels. These interesting findings open up new possibilities of using NAD-GDH modulating agents to control flocculation in fermentations for easier downstream processing696792
diagnosticsHomo sapiens-GLDH, gama-glutamyltransferase, aspartate-aminotransferase, alanine-aminotransferase and erythrocyte mean cell volume are assessed in 238 alcoholics admitted to hospital: on admission, after 24 h and after 7 days. All the values are significantly higher than those in healthy persons. The fastest activity decrease is seen in GLDH. The kinetics of GLDH and aspartate-aminotranferase are more applicable than gama-glutamyltransferase kinetics after a week, but GLDH kinetics are most reliable. GLDH is the most specific laboratory marker with almost 90% specificity. The sensitivity of combination erythrocyte mean cell volume and GLDH kinetics after 1 week of abstinence is pathognomonic by 97.2%. GLDH is an equally accurate marker of alcoholism in comparison to others695431
medicineHomo sapiens-the findings emphasize the integration of glucose metabolism, glutamine metabolism, and oncogenic signaling in glioblastoma cells and suggest that exploiting compensatory pathways of glutamine metabolism can improve the efficacy of cancer treatments that impair glucose utilization697113
molecular biologyMus musculus-GDH is essential for the full development of the secretory response in beta-cells698996
agricultureNicotiana tabacum-GDH genes involved in leaf senescence are also a component of the plant defence response during plant–pathogen interaction, GDH behaves like a non-specific stress-related gene675147
degradationNicotiana tabacum-clarification of the in vivo direction of the reaction catalyzed by GDH isoenzyme 1, the enzyme catabolizes L-glutamate in roots, and does not assimilate NH4+ in source leaves676630
medicineRattus norvegicus-prolonged exposure to Corydalis ternata may be one of the ways to regulate glutamate concentration in brain through the activation of GDH673480
diagnosticsStreptococcus suis-GDH electrophoretic type (ETs) and sequence types may serve as useful markers in predicting the pathogenic behavior of strains of this serotype and that the molecular basis for the observed differences in the ETs is amino acid substitutions and not deletion, insertion, or processing uniqueness699188
biotechnologyThermus thermophilus-method describes immobilization of enzymes by the maximum amount of subunits and rigidification of the enzyme subunits involved in the immobilization697661
agricultureTriticum aestivum-plays some role in triticale plant’s defence against effects of different types of environmental stresses671178
additional informationBacillus subtilisP39633Q144R can be used as a template gene to modify the substrate specificity of Bacillus subtilis GluDH for industrial use672661
food industryBrassica oleraceaQ50JE9plays an essential role during postharvest senescence, its expression most likely is controlled by multigenes and regulated either transcriptionally or posttranscriptionally672773
additional informationClostridium symbiosum-reactivation of D165N is a consequence of the catalytic chemistry of the enzyme’s active site673612
additional informationEntodinium caudatumQ9TVN3high sequence similarity to GDH genes from the Bacteroides, GDH is an anabolic enzyme catalysing the assimilation of ammonia by Entodinium caudatum in the rumen, the gene is probably acquired by lateral gene transfer from a ruminal bacterium673715
molecular biologyNicotiana tabacum-GDH, in conjunction with NADH-glutamte synthase, contributes to the control of leaf glutamate homeostasis, an amino acid that plays a central signaling and metabolic role at the interface of the carbon and nitrogen assimilatory pathways700719
additional informationNicotiana tabacum-glutamine synthetase-GOGAT pathway and GDH play distinct roles in the source-sink nitrogen cycle of tobacco leaves, regardless of leaf age, [15N]ammonium does not depend on GDH676596
additional informationNicotiana tabacumQ67C42, Q67C43GDH gene expression and translation are apparently subject to complex regulation; large modulation of GDH beta-subunit titre does not affect plant viability under ideal growing conditions, GDH gene expression and translation are apparently subject to complex regulation676690
additional informationOryza sativaQ852M0induction of GDH1 and GDH2 transcripts along the root do not coincide with that of NADH-GOGAT expression670544
additional informationPhaseolus vulgaris-possible role of enzyme under Hg-stress673970
additional informationPyrobaculum islandicum-subunit rearrangement, i.e., a change in the quaternary structure of the hexameric recombinant GDH, is essential for activation of the enzyme671995
degradationTriticum aestivum-at high salinity glutamate seems to be preferentially produced through the process catalyzed by NADH-GDH, whereas GS-catalysis might be the main glutamate synthesis pathway under low salinity675664
additional informationTriticum aestivum-shift in GDH cellular compartmentation is important during leaf nitrogen remobilization663075

DISEASETITLE OF PUBLICATIONLINK TO PUBMED
3-hydroxyacyl-coa dehydrogenase deficiencyMechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. PubMed
3-hydroxyacyl-coa dehydrogenase deficiencyTwo genetic forms of hyperinsulinemic hypoglycemia caused by dysregulation of glutamate dehydrogenase. PubMed
Abscess[Application of serum glutamic dehydrogenase for the diagnosis of hepatic carcinoma and abscess and for the evaluation of their treatment (author's transl)] PubMed
AcidosisActivation of oxoglutarate dehydrogenase in the kidney in response to acute acidosis. PubMed
AcidosisAdaptation of renal tricarboxylic acid cycle metabolism to various acid-base states: study with [3-13C,5-15N]glutamine. PubMed
AcidosisAmmoniagenesis by cultured human renal cortical epithelial cells: study with 15N. PubMed
AcidosisBiochemical and histocytochemical studies on response of ammonia-producing enzymes for nh4cl-induced acidosis. PubMed
AcidosisBiochemical pathways and modulators of renal ammoniagenesis. PubMed
AcidosisChanges in the profile of liver enzymes in newborn calves induced by experimental, subclinical acidosis in pregnant cows and osmotic diarrhoea. PubMed
AcidosisEffect of acute metabolic acidosis on ammonia metabolism in kidney. PubMed
AcidosisEffect of altered acid-base balance and of various agonists on levels of renal glutamate dehydrogenase mRNA. PubMed
AcidosisEvidence of activation of the renal glutamate dehydrogenase pathway in intact acidotic dogs. PubMed
AcidosisHormonal regulation of glutamine metabolism by OK cells. PubMed
AcidosisInhibition of glutamine synthetase in the mouse kidney: a novel mechanism of adaptation to metabolic acidosis. PubMed
AcidosisMetabolism and transport of L-glutamine and L-alanine by renal tubules of chickens. PubMed
AcidosisMetabolism of glutamine and glutamate by rat renal tubules. Study with 15N and gas chromatography-mass spectrometry. PubMed
AcidosisMetabolism of [2-13C]succinate in renal cells determined by 13C NMR. PubMed
AcidosisNewer aspects of glutamine/glutamate metabolism: the role of acute pH changes. PubMed
AcidosispH-responsive stabilization of glutamate dehydrogenase mRNA in LLC-PK1-F+ cells. PubMed
AcidosisRegulation of glutamate dehydrogenase by branched-chain amino acids in skeletal muscle from rats and chicks. PubMed
AcidosisRenal metabolite concentrations and the activities of glutaminase and glutamate dehydrogenase during recovery from metabolic acidosis in the rat. PubMed
AcidosisThe kidney of chicken adapts to chronic metabolic acidosis: in vivo and in vitro studies. PubMed
AcidosisThe role of glutamate dehydrogenase in mammalian ammonia metabolism. PubMed
Acidosis[Interrelation of fetal metabolism and late pregnancy in animals] PubMed
Acquired Immunodeficiency SyndromeChronic subclinical ovine fascioliasis: plasma glutamate dehydrogenase, gamma-glutamyl transpeptidase and aspartate aminotransferase activities and their significance as diagnostic aids. PubMed
AcrodyniagdhB, a gene encoding a second quinoprotein glucose dehydrogenase in Pantoea citrea, is required for pink disease of pineapple. PubMed
AcrodyniaIdentification and characterization of a Pantoea citrea gene encoding glucose dehydrogenase that is essential for causing pink disease of pineapple. PubMed
Adenocarcinoma[Oxidoreductase activity in the cells of stomach cancer] PubMed
Adrenocortical HyperfunctionEffect of serum storage, anti-inflammatory oral doses of prednisone, and spontaneous hyperadrenocorticism on serum glutamate dehydrogenase activity in dogs. PubMed
Alzheimer DiseaseGlutamate metabolizing enzymes in prefrontal cortex of Alzheimer's disease patients. PubMed
Alzheimer DiseaseImplications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients. PubMed
Alzheimer DiseaseLymphocyte glutamate dehydrogenase activity in normal aging and neurological diseases. PubMed
Alzheimer DiseasePlasma concentrations of glutamate and its metabolites in patients with Alzheimer's disease. PubMed
Alzheimer Disease[Impaired cerebral glutamate metabolism in mental diseases (Alzheimer's disease, schizophrenia] PubMed
Amyotrophic Lateral SclerosisAmyotrophic lateral sclerosis: glutamate dehydrogenase and transmitter amino acids in the spinal cord. PubMed
Amyotrophic Lateral SclerosisGlutamate dehydrogenase activity in amyotrophic lateral sclerosis. PubMed
AnemiaNTP Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). PubMed
AsbestosisBiochemical mechanisms in asbestos toxicity. PubMed
AtaxiaD-Serine regulates cerebellar LTD and motor coordination through the ?2 glutamate receptor. PubMed
AtaxiaGlutamate dehydrogenase deficiency in Machado-Joseph disease. PubMed
AtaxiaGlutamate dehydrogenase deficiency in patients with olivopontocerebellar atrophy. PubMed
AtaxiaLeucocyte glutamate dehydrogenase in various hereditary ataxias. PubMed
AtaxiaLeukocyte glutamate dehydrogenase and CSF amino acids in late onset ataxias. PubMed,  PubMed
AtaxiaThe N-terminal domain of GluD2 (GluRdelta2) recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo. PubMed
Basal Ganglia DiseasesDegenerative neurological disorders associated with deficiency of glutamate dehydrogenase. PubMed
beta-ThalassemiaGlycerol-3-phosphate dehydrogenase activity in the red cells of patients with thalassemia. PubMed
Brain Concussion[Changes in the activities of oxidoreductases, content of malondialdehyde and medium weight molecules in the blood of patients with craniocerebral injuries of different severity] PubMed
Brain Diseases, MetabolicDifferential effects of fatty acyl coenzyme A derivatives on citrate synthase and glutamate dehydrogenase. PubMed
Brain Neoplasms[Activities of glutamate dehydrogenase and aspartate aminotransferase in human brain tumors] PubMed
CarcinomaEnzyme activities and level of SH groups in breast carcinomas. PubMed
CarcinomaEnzyme activities in human breast tumours. PubMed
CarcinomaFlow-cytometric determination of dehydrogenase activities in primary human gastrointestinal tumor cell lines. PubMed
Carcinoma[Application of serum glutamic dehydrogenase for the diagnosis of hepatic carcinoma and abscess and for the evaluation of their treatment (author's transl)] PubMed
Carcinoma[Glutamate dehydrogenase from human liver. VI. Glutamate dehydrogenase in primary liver cell carcinomas] PubMed
Carcinoma[Laboratory tests in the diagnosis of stomach cancer] PubMed
Carcinoma, Ehrlich TumorChanges in enzyme pattern of Ehrlich ascites tumor cells following serial cultivation in media with increased (hypertonic) NaCl content. PubMed
Carcinoma, Ehrlich TumorEnzyme activities of six different dehydrogenases in Ehrlich ascites cells measured by flow cytometry. PubMed
Carcinoma, HepatocellularCharacterization of glutamate dehydrogenase isoproteins purified from the cerebellum of normal subjects and patients with degenerative neurological disorders, and from human neoplastic cell lines. PubMed
Carcinoma, HepatocellularEffects of glutamate dehydrogenase, choline oxidase, and glucose-6-phosphatase on 67Ga accumulation in lysosome. PubMed
Carcinoma, HepatocellularGlutamate dehydrogenase activity related to histopathological grade of hepatocellular carcinoma in man. PubMed
Carcinoma, HepatocellularProceedings: Grade of histological differentiation, glutamate dehydrogenase activity and alphafetoprotein production in human hepatocellular carcinoma. PubMed
Carcinoma, HepatocellularSerum level of ornithine carbamoyltransferase is influenced by the state of Kupffer cells. PubMed
Carcinoma, HepatocellularThe comparative enzymology and cell origin of rat hepatomas. II. Glutamate dehydrogenase, choline oxidase, and glucose-6-phosphatase. PubMed
Carcinoma, Hepatocellular[Evaluation of serum glutamic dehydrogenase activity in the diagnosis and treatment of hepatocellular carcinoma and liver metastasis] PubMed
Carcinoma, Hepatocellular[Glutamate dehydrogenase from human liver. VI. Glutamate dehydrogenase in primary liver cell carcinomas] PubMed
Cell Transformation, NeoplasticGlutaminolysis and glycolysis regulation by troglitazone in breast cancer cells: relationship to mitochondrial membrane potential. PubMed
Cerebellar AtaxiaGlutamate dehydrogenase (GDH) deficiency in different types of progressive hereditary cerebellar ataxia. PubMed
Cerebellar AtaxiaLeukocyte glutamate dehydrogenase and CSF amino acids in late onset ataxias. PubMed,  PubMed
Chagas DiseaseComparative study of enzymes in testes and ovaries from adult Dipetalogaster maximus (Uhler) and triatoma infestans (Klug) (Hemiptera: Reduviidae). correlation with fine structural organization. PubMed
CholestasisActivities of APh, gamma-GT, GlDH and GPT and bile acid concentrations in serum after bile duct obstruction and cycloheximide in the rat. PubMed
CholestasisValue of so called cholestasis markers in the dog: an experimental study. PubMed
Coccidiosis[Alteration of enzyme activities in serum of Eimeria stiedai infected rabbits (author's transl)] PubMed
CoinfectionDominance of Giardia assemblage B in León, Nicaragua. PubMed
CoinfectionHigh genetic polymorphism among Giardia duodenalis isolates from Sahrawi children. PubMed
CoinfectionMultiple-subgenotype infections of Giardia intestinalis detected in Palestinian clinical cases using a subcloning approach. PubMed
CoinfectionSubclass profile of specific IgG antibodies in rats challenged during acute and chronic primary infection with Fasciola hepatica. PubMed
Cold IschemiaDetermination of hepatocellular enzymes in effluent of human liver grafts for preoperative evaluation of transplant quality. PubMed
Colonic NeoplasmsEmergency presentation of colon cancer is most frequent during summer. PubMed
ComaAcute metabolic effects of ammonia on the enzymes of glutamate metabolism in isolated astroglial cells. PubMed
ComaEffect of total hepatectomy on selected cerebral substrates and enzymes of the glycolytic pathways and Krebs cycle. PubMed
Congenital HyperinsulinismA Japanese case of congenital hyperinsulinism with hyperammonemia due to a mutation in glutamate dehydrogenase (GLUD1) gene. PubMed
Congenital HyperinsulinismBiochemical evaluation of an infant with hypoglycemia resulting from a novel de novo mutation of the GLUD1 gene and hyperinsulinism-hyperammonemia syndrome. PubMed
Congenital HyperinsulinismCalcium-stimulated insulin secretion in diffuse and focal forms of congenital hyperinsulinism. PubMed
Congenital HyperinsulinismDisorders of glutamate metabolism. PubMed
Congenital HyperinsulinismGlutaminolysis and insulin secretion: from bedside to bench and back. PubMed
Congenital HyperinsulinismHyperinsulinism in infancy and childhood: when an insulin level is not always enough. PubMed
Congenital HyperinsulinismHyperinsulinism/hyperammonemia syndrome: insights into the regulatory role of glutamate dehydrogenase in ammonia metabolism. PubMed
Congenital HyperinsulinismMechanisms of Disease: advances in diagnosis and treatment of hyperinsulinism in neonates. PubMed
Congenital HyperinsulinismMolecular characterisation of glutamate dehydrogenase gene defects in Japanese patients with congenital hyperinsulinism/hyperammonaemia. PubMed
Congenital HyperinsulinismNeurological aspects of hyperinsulinism-hyperammonaemia syndrome. PubMed
Congenital HyperinsulinismRare forms of congenital hyperinsulinism. PubMed
Congenital HyperinsulinismSpectrum of glutamate dehydrogenase mutations in Japanese patients with congenital hyperinsulinism and hyperammonemia syndrome. PubMed
Congenital Hyperinsulinism[Hyperinsulinism in infancy and childhood: when an insulin level is not always enough.] PubMed
Congenital Hyperinsulinism[Mutation analysis of the GLUD1 gene in patients with glutamate dehydrogenase congenital hyperinsulinism.] PubMed
Cystic FibrosisTiming and sequence of differentiation of embryonic rat hepatocytes along the biliary epithelial lineage. PubMed
CystsComparison of two target genes for detection and genotyping of Giardia lamblia in human feces by PCR and PCR-restriction fragment length polymorphism. PubMed
CystsDiscrimination of all genotypes of Giardia duodenalis at the glutamate dehydrogenase locus using PCR-RFLP. PubMed
CystsGiardia intestinalis in Thailand: identification of genotypes. PubMed
CystsHigh genetic polymorphism among Giardia duodenalis isolates from Sahrawi children. PubMed
CystsHistoenzymological study of selected dehydrogenase enzymes in Pneumocystis carinii. PubMed
CystsImproved sensitivity of PCR amplification of glutamate dehydrogenase gene for detection and genotyping of Giardia duodenalis in stool specimen. PubMed
CystsMolecular characterisation of Giardia isolates from clinical infections following a waterborne outbreak. PubMed
CystsMolecular identification of Giardia duodenalis isolates from humans, dogs, cats and cattle from the state of São Paulo, Brazil, by sequence analysis of fragments of glutamate dehydrogenase (gdh) coding gene. PubMed
CystsSarcocystis fusiformis: some protein metabolic enzymes in various fractions of sarcocysts of buffalo (Bubalus bubalis). PubMed
CystsSynthesis of pyruvate: ferredoxin oxidoreductase and alcohol dehydrogenase E enzymes during Giardia intestinalis excystation. PubMed
CystsTranscription of metabolic enzyme genes during the excystation of Giardia lamblia. PubMed
DehydrationComparative study of enzymes related to proline metabolism in tepary bean (Phaseolus acutifolius) and common bean (Phaseolus vulgaris) under drought and irrigated conditions, and various urea concentrations. PubMed
Dementia[Geriatric day hospital: what evidence? A systematic review]. PubMed
Dental Plaque[Biochemical studies of glutamate dehydrogenase in fusobacterium from human dental plaque (author's transl)] PubMed
Diabetes Mellitus, Experimental[Changes of some energy exchange parameters in the rat heart under insulin hypoglycemia] PubMed
Diabetes, GestationalLow mitochondrial glycerophosphate dehydrogenase activity in lymphocytes of women with gestational diabetes. PubMed
DiphtheriaFolding funnels and conformational transitions via hinge-bending motions. PubMed
Down SyndromeMitochondrial enzyme deficiencies in Down's syndrome. PubMed
Dysentery[Findings concerning characteristics of responses to administration of vaccines containing antigenic complexes of enteric bacteria and tetanus toxoid] PubMed
DystoniaGeneralized dystonia in a patient with a novel mutation in the GLUD1 gene. PubMed
Endotoxemia[The effect of triamcinolone acetonide on the liver mitochondria in endotoxemia] PubMed
Epilepsies, MyoclonicMyoclonic absence epilepsy with photosensitivity and a gain of function mutation in glutamate dehydrogenase. PubMed
Epilepsies, PartialEnzyme changes in actively spiking areas of human epileptic cerebral cortex. PubMed
Epilepsies, PartialFamilial increase in plasma glutamic acid in epilepsy. PubMed
EpilepsyCentral nervous system hyperexcitability associated with glutamate dehydrogenase gain of function mutations. PubMed
EpilepsyDifferential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy. PubMed
EpilepsyExpression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsy. PubMed
EpilepsyHyperinsulinism-hyperammonaemia syndrome: novel mutations in the GLUD1 gene and genotype-phenotype correlations. PubMed
EpilepsyMyoclonic absence epilepsy with photosensitivity and a gain of function mutation in glutamate dehydrogenase. PubMed
EpilepsyNeurological aspects of hyperinsulinism-hyperammonaemia syndrome. PubMed
Epilepsy[Glutamate dehydrogenase determination in epilepsy] PubMed
Epilepsy[Metabolic investigations of epileptic seizures: the role of aminotransferases and glutamate dehydrogenase in convulsions] PubMed
Epilepsy, AbsenceSpecific alteration in the expression of glial fibrillary acidic protein, glutamate dehydrogenase, and glutamine synthetase in rats with genetic absence epilepsy. PubMed
Epilepsy, GeneralizedFamilial increase in plasma glutamic acid in epilepsy. PubMed
Epilepsy, GeneralizedTwo genetic forms of hyperinsulinemic hypoglycemia caused by dysregulation of glutamate dehydrogenase. PubMed
Epilepsy, Temporal LobeDifferential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy. PubMed
Epilepsy, Temporal LobeExpression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsy. PubMed
FascioliasisBiochemical indicators of liver injury in calves with experimental fascioliasis. PubMed
FascioliasisChronic subclinical ovine fascioliasis: plasma glutamate dehydrogenase, gamma-glutamyl transpeptidase and aspartate aminotransferase activities and their significance as diagnostic aids. PubMed
FascioliasisResponse of goats to repeated infections with Fasciola gigantica. PubMed
Fatty LiverBiochemical changes associated with the fatty liver syndrome in cows. PubMed
Fatty LiverClinicopathological evaluation of downer dairy cows with fatty liver. PubMed
Fatty LiverEvaluation of ornithine carbamoyl transferase and other serum and liver-derived analytes in diagnosis of fatty liver and postsurgical outcome of left-displaced abomasum in dairy cows. PubMed
Fatty LiverGlucose and insulin responses to glucagon injection in dairy cows with ketosis and fatty liver. PubMed
Fatty LiverPolyenylphosphatidylcholine attenuates alcohol-induced fatty liver and hyperlipemia in rats. PubMed
Fatty Liver, AlcoholicHepatic gamma-glutamyltransferase activity in alcoholic fatty liver: comparison with other liver enzymes in man and rats. PubMed
FavismSerum glutamic oxalacetic transaminase, glutamic pyruvic transaminase, gamma-glutamyl transpeptidase and glutamic dehydrogenase levels in favism. PubMed
FibrosarcomaGlutamate dehydrogenase activity in subcellular fractions of mouse fibrosarcoma. PubMed
Friedreich AtaxiaAbnormalities of mitochondrial enzymes in hereditary ataxias. PubMed
GallstonesClinical and pathological studies in cattle with hepatic disease. PubMed
GiardiasisComparison of two target genes for detection and genotyping of Giardia lamblia in human feces by PCR and PCR-restriction fragment length polymorphism. PubMed
GiardiasisHigh prevalence Giardia duodenalis assemblage B and potentially zoonotic subtypes in sporadic human cases in Western Australia. PubMed
Gingivitis[Activity of glutamate dehydrogenase, gamma-glutamyltranspeptidase and creatine kinase in saliva in gingivitis] PubMed
GlioblastomaGlioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or akt signaling. PubMed
Glioblastoma[Primary and secondary glioblastoma. Distinction by glutamate dehydrogenase activity] PubMed
GliomaCharacterization of glutamate dehydrogenase isoproteins purified from the cerebellum of normal subjects and patients with degenerative neurological disorders, and from human neoplastic cell lines. PubMed
glutamate dehydrogenase deficiencyClinical expression of glutamate dehydrogenase deficiency. PubMed
glutamate dehydrogenase deficiencyDecreased glutamate dehydrogenase protein in spinocerebellar degeneration. PubMed
glutamate dehydrogenase deficiencyDecreased viability of skin fibroblasts from patients with glutamate dehydrogenase deficiency. PubMed
glutamate dehydrogenase deficiencyGlutamate dehydrogenase (GDH) deficiency in different types of progressive hereditary cerebellar ataxia. PubMed
glutamate dehydrogenase deficiencyGlutamate dehydrogenase and aspartate aminotransferase in leukocytes of patients with motor neuron disease. PubMed
glutamate dehydrogenase deficiencyGlutamate dehydrogenase and its isozyme activity in olivopontocerebellar atrophy. PubMed
glutamate dehydrogenase deficiencyGlutamate dehydrogenase deficiency in cerebellar degenerations: clinical, biochemical and molecular genetic aspects. PubMed
glutamate dehydrogenase deficiencyGlutamate dehydrogenase deficiency in Machado-Joseph disease. PubMed
glutamate dehydrogenase deficiencyGlutamate dehydrogenase deficiency in patients with olivopontocerebellar atrophy. PubMed
glutamate dehydrogenase deficiencyGlutamate dehydrogenase deficiency in spinocerebellar degenerations. PubMed
glutamate dehydrogenase deficiencyGlutamate dehydrogenase deficiency in three patients with spinocerebellar ataxia: a new enzymatic defect? PubMed
glutamate dehydrogenase deficiencyGlutamate dehydrogenase deficiency in three patients with spinocerebellar syndrome. PubMed
glutamate dehydrogenase deficiencyGlutamate dehydrogenase isoenzymes in the bovine retina and human leukocyte. PubMed
glutamate dehydrogenase deficiencyMultiple system degeneration with glutamate dehydrogenase deficiency: pathology and biochemistry. PubMed
glutamate dehydrogenase deficiencyMutation analysis in glutaric aciduria type I. PubMed
glutamate dehydrogenase deficiencyNeonatal hyperinsulinemic hypoglycemia. Two case reports. PubMed
glutamate dehydrogenase deficiencyNeurological disorders associated with deficiency of glutamate dehydrogenase. PubMed
glutamate dehydrogenase deficiencyNeurophysiologic study of olivopontocerebellar atrophy with or without glutamate dehydrogenase deficiency. PubMed
glutamate dehydrogenase deficiencyPathology of olivopontocerebellar atrophy with glutamate dehydrogenase deficiency. PubMed
glutamate dehydrogenase deficiencyThe natural history of hyperuricemia among asymptomatic relatives of patients with gout. PubMed
Heart FailureThe diagnostic significance of liver cell inhomogeneity: serum enzymes in patients with central liver necrosis and the distribution of glutamate dehydrogenase in normal human liver. PubMed
Heart Failure[Fibrosing reaction of nutmeg liver] PubMed
Hepatic EncephalopathyEffects of acute hepatic encephalopathy and in vitro treatment with ammonia on glutamate oxidation in bulk-isolated astrocytes and mitochondria of the rat brain. PubMed
Hepatic EncephalopathyHistochemical studies in experimental portal-systemic encephalopathy. PubMed
Hepatic EncephalopathyHyperammonemia and hepatic encephalopathy stimulate rat cerebral synaptic mitochondrial glutamate dehydrogenase activity specifically in the direction of glutamate oxidation. PubMed
Hepatic Encephalopathy[Changes of glutamic dehydrogenase and ornithine carbamyl transferase activities in sera in patients with hepatic encephalopathy] PubMed
Hepatic Encephalopathy[The enzymatic activity of ammonia metabolism in the liver during the parenteral nitrogen feeding of animals with experimental liver failure] PubMed
Hepatic Insufficiency[The enzymatic activity of ammonia metabolism in the liver during the parenteral nitrogen feeding of animals with experimental liver failure] PubMed
HepatitisA diagnostic approach to different types of non-A non-B acute hepatitis through the evaluation of the lobular distribution of hepatocytic damage. PubMed
HepatitisGlutamate dehydrogenase: a reliable marker of liver cell necrosis in the alcoholic. PubMed
HepatitisMultivariate analysis of an enzymic profile for the differential diagnosis of viral hepatitis. PubMed
HepatitisT cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay? PubMed
Hepatitis[Clinical evaluation of glutamate dehydrogenase in viral hepatitis and jaundice of other origins] PubMed
Hepatitis[Comparative studies on vitamin B 12 and glutamic dehydrogenase serum levels in children with acute viral hepatitis] PubMed
Hepatitis[Glutamate dehydrogenase activity in the blood serum in viral hepatitis and other liver diseases] PubMed
Hepatitis[Glutamate dehydrogenase in the course of viral hepatitis] PubMed
Hepatitis[Glutamate dehydrogenase in viral hepatitis] PubMed
Hepatitis[Glutamic dehydrogenase and alcohol dehydrogenase of blood in various conditions of experimental hepatic necrosis: hepatitis due to MHV-3 virus, acute poisoning due to carbon tetrachloride.] PubMed
Hepatitis[Research on the diagnostic value of some enzyme activities in icteric hepatitis in childhood. I. Ornithine carbamoyltransferase and glutamate dehydrogenase] PubMed
Hepatitis[Significance of the determination of glutamate dehydrogenase (GLDH) in viral hepatitis in childhood] PubMed
Hepatitis[Significance of the proteinogram and the determination of glutamate dehydrogenase in atypical forms of viral hepatitis] PubMed
Hepatitis A[Drug-induced hepatitis] PubMed
Hepatitis, AlcoholicSerum glutamate dehydrogenase is not a reliable marker of liver cell necrosis in alcoholics. PubMed
Hepatitis, Alcoholic[Glutamate dehydrogenase and acute alcoholic hepatitis] PubMed
Hepatitis, ChronicChronic hepatitis induced by alcohol. PubMed
Hepatitis, ChronicHepatic activity and mRNA expression of aspartate aminotransferase isoenzymes in alcoholic and nonalcoholic liver disease. PubMed
Hepatitis, ChronicMultivariate analysis of an enzymic profile for the differential diagnosis of viral hepatitis. PubMed
HyperalgesiaIntraplantar injection of gangliosides produces nociceptive behavior and hyperalgesia via a glutamate signaling mechanism. PubMed
HypercholesterolemiaThe influence of fluoride ions upon selected enzymes of protein metabolism in blood plasma of rabbits with hypercholesterolemia. PubMed
HyperglycemiaEffects of sodium nitroprusside on blood glucose concentration, B-cell morphology and islet glutamate dehydrogenase activity in mice. PubMed
HyperinsulinismA Japanese case of congenital hyperinsulinism with hyperammonemia due to a mutation in glutamate dehydrogenase (GLUD1) gene. PubMed
HyperinsulinismCalcium-stimulated insulin secretion in diffuse and focal forms of congenital hyperinsulinism. PubMed
HyperinsulinismClinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism. PubMed
HyperinsulinismCongenital hyperinsulinism: molecular basis of a heterogeneous disease. PubMed
HyperinsulinismDiazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. PubMed
HyperinsulinismDominantly inherited hyperinsulinaemic hypoglycaemia. PubMed
HyperinsulinismFrom pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis. PubMed
HyperinsulinismFunctional hyperactivity of hepatic glutamate dehydrogenase as a cause of the hyperinsulinism/hyperammonemia syndrome: effect of treatment. PubMed
HyperinsulinismHunting for a hypoglycemia gene: severe neonatal hypoglycemia in a consanguineous family. PubMed
HyperinsulinismHyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. PubMed
HyperinsulinismHyperinsulinism of the newborn. PubMed
HyperinsulinismImpaired FAD-glycerophosphate dehydrogenase activity in islet and liver homogenates of fa/fa rats. PubMed
HyperinsulinismMechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. PubMed
HyperinsulinismMitochondrial signals in glucose-stimulated insulin secretion in the beta cell. PubMed
HyperinsulinismProtein causes hyperinsulinemia: a Chinese patient with hyperinsulinism/hyperammonaemia syndrome due to a glutamate dehydrogenase gene mutation. PubMed
HyperinsulinismShort-chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with hyperinsulinism: a novel glucose-fatty acid cycle? PubMed
HyperinsulinismShort-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. PubMed
HyperinsulinismStimulatory effects of malathion on the key enzymes activities of insulin secretion in langerhans islets, glutamate dehydrogenase and glucokinase. PubMed
HyperinsulinismThe genetics of neonatal hyperinsulinism. PubMed
HyperinsulinismTwo genetic forms of hyperinsulinemic hypoglycemia caused by dysregulation of glutamate dehydrogenase. PubMed
HyperinsulinismTwo unrelated Chinese patients with hyperinsulinism /hyperammonemia (HI/HA) syndrome due to mutations in glutamate dehydrogenase gene. PubMed
HyperkalemiaComparison of classic hypoadrenocorticism with glucocorticoid-deficient hypoadrenocorticism in dogs: 46 cases (1985-2005). PubMed
HyperlipidemiasPolyenylphosphatidylcholine attenuates alcohol-induced fatty liver and hyperlipemia in rats. PubMed
Hyperoxaluria, PrimaryEnzymological characterization of a feline analogue of primary hyperoxaluria type 2: a model for the human disease. PubMed
HypersensitivityGlutaminolysis and insulin secretion: from bedside to bench and back. PubMed
Hyperthyroidism[Effect of experimental changes in thyroid function on oxidative metabolism and glutamate dehydrogenase activity in the limbic system of the rat] PubMed
HypoglycemiaBiochemical evaluation of an infant with hypoglycemia resulting from a novel de novo mutation of the GLUD1 gene and hyperinsulinism-hyperammonemia syndrome. PubMed
HypoglycemiaCentral nervous system hyperexcitability associated with glutamate dehydrogenase gain of function mutations. PubMed
HypoglycemiaEffects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice. PubMed
HypoglycemiaFamilial leucine-sensitive hypoglycemia of infancy due to a dominant mutation of the beta-cell sulfonylurea receptor. PubMed
HypoglycemiaGlutaminolysis and insulin secretion: from bedside to bench and back. PubMed
HypoglycemiaGREEN TEA POLYPHENOLS CONTROL DYSREGULATED GLUTAMATE DEHYDROGENASE IN TRANSGENIC MICE BY HIJACKING THE ADP ACTIVATION SITE. PubMed
HypoglycemiaMyoclonic absence epilepsy with photosensitivity and a gain of function mutation in glutamate dehydrogenase. PubMed
HypoglycemiaOverexpression of constitutively activated glutamate dehydrogenase induces insulin secretion through enhanced glutamate oxidation. PubMed
HypoglycemiaProtein-sensitive hypoglycemia without leucine sensitivity in hyperinsulinism caused by K(ATP) channel mutations. PubMed
HypoglycemiaRegulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets. PubMed
HypoglycemiaTwo genetic forms of hyperinsulinemic hypoglycemia caused by dysregulation of glutamate dehydrogenase. PubMed
HypoglycemiaUnregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion: identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamate dehydrogenase. PubMed
Hypoglycemia[Parameters of energy and nitrogen metabolism in rats under insulin-induced hypoglycemia] PubMed
Hypokinesia[Activity of various oxidases and transaminases in the rat liver in the readaptation period after hypokinesia up to 30 days] PubMed
HyponatremiaComparison of classic hypoadrenocorticism with glucocorticoid-deficient hypoadrenocorticism in dogs: 46 cases (1985-2005). PubMed
Hypothyroidism[Effect of experimental changes in thyroid function on oxidative metabolism and glutamate dehydrogenase activity in the limbic system of the rat] PubMed
InfectionAlgorithm combining toxin immunoassay and stool culture for diagnosis of Clostridium difficile infection. PubMed
InfectionAlgorithm proposal based on the C. Diff Quik Chek Complete ICT device for detecting Clostridium difficile infection. PubMed
InfectionAn integrated analysis of enzyme activities, cofactor pools and metabolic fluxes in baculovirus-infected Spodoptera frugiperda Sf9 cells. PubMed
InfectionCharacterization of Streptococcus suis serotype 2 blood infections using RT-qPCR to quantify glutamate dehydrogenase copy numbers. PubMed
InfectionChronic subclinical ovine fascioliasis: plasma glutamate dehydrogenase, gamma-glutamyl transpeptidase and aspartate aminotransferase activities and their significance as diagnostic aids. PubMed
InfectionClostridium difficile testing algorithms: What is practical and feasible? PubMed
InfectionDetection of glutamate dehydrogenase enzyme activity in Plasmodium falciparum infection. PubMed
InfectionDoes my patient have Clostridium difficile infection? PubMed
InfectionEfficacy of an injectable combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle. PubMed
InfectionEvaluation of a simultaneous detection kit for the glutamate dehydrogenase antigen and toxin A/B in feces for diagnosis of Clostridium difficile infection. PubMed
InfectionEvolution of Testing Algorithms at a University Hospital for Detection of Clostridium difficile Infections. PubMed
InfectionGlutamate dehydrogenase antigen detection in Plasmodium falciparum infections. PubMed
InfectionGlutamate dehydrogenase for laboratory diagnosis of Clostridium difficile infection. PubMed
InfectionLaboratory diagnosis of clostridium difficile infection. An evaluation of tests for faecal toxin, glutamate dehydrogenase, lactoferrin and toxigenic culture in the diagnostic laboratory. PubMed
InfectionMixed Giardia duodenalis assemblage infections in children and adults in South India. PubMed
InfectionPlasma aspartate aminotransferase (AST), glutamate dehydrogenase (GLDH) and gamma-glutamyl transpeptidase (GGT) activities in water buffaloes with experimental subclinical fasciolosis. PubMed
InfectionRapid identification of Giardia duodenalis assemblages in NSW using terminal-restriction fragment length polymorphism. PubMed
InfectionResponse of goats to repeated infections with Fasciola gigantica. PubMed
InfectionSerum and bile antibody responses (IgG and IgA) during subclinical Fasciola hepatica infection in sheep. PubMed
InfectionSerum enzyme tests in hepatosplenic schistosomiasis. PubMed
InfectionStudies on ammonia-metabolizing enzymes during Plasmodium yoelii infection and pyrimethamine treatment in mice. PubMed
InfectionSusceptibility to homologous reinfection with Fasciola gigantica in goats. PubMed
InfectionThe effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep. PubMed
InfectionThe effects of fascioliasis on the activities of some drug-metabolizing enzymes in desert sheep liver. PubMed
InfectionThe fate of glutamate in different brain regions of the chick during Newcastle disease virus infection. PubMed
InfectionThe resistance of sheep to Fasciola hepatica: studies on the pathophysiology of challenge infections. PubMed
InfectionThe zoonotic potential of Giardia and Cryptosporidium in Norwegian sheep: A longitudinal investigation of 6 flocks of lambs. PubMed
Infection[Alteration of enzyme activities in serum of Eimeria stiedai infected rabbits (author's transl)] PubMed
Infectious MononucleosisGlutamate dehydrogenase activity in lymphocytes of B-cell chronic lymphocytic leukaemia patients. PubMed
Insulin ResistanceBlood profiles in dairy cows with displaced abomasum. PubMed
InsulinomaCalcium-stimulated insulin secretion in diffuse and focal forms of congenital hyperinsulinism. PubMed
InsulinomaOverexpression of constitutively activated glutamate dehydrogenase induces insulin secretion through enhanced glutamate oxidation. PubMed
InsulinomaSIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. PubMed
InsulinomaUnregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion: identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamate dehydrogenase. PubMed
Intestinal Diseases[Alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutamate dehydrogenase (GLDH), alkaline phosphatase (AP) and gamma-glutamyltransferase (GGP) in intestinal diseases of dogs] PubMed
KetosisGlucose and insulin responses to glucagon injection in dairy cows with ketosis and fatty liver. PubMed
LeptospirosisClinical and pathological studies in cattle with hepatic disease. PubMed
LeukemiaGlutamic acid dehydrogenase and glutamic-oxalacetic transaminase of blood in leukemia and cancer. PubMed
Leukemia[Characteristics of leukemic blood cells. V. Glutamic acid dehydrogenase in leukemias and summary.] PubMed
Leukemia, LymphoidGlutamate dehydrogenase activity in lymphocytes of B-cell chronic lymphocytic leukaemia patients. PubMed
LipidosesClinical and pathological studies in cattle with hepatic disease. PubMed
LipidosesClinical and pathological studies in horses with hepatic disease. PubMed
LipidosesEffect on liver function of acetonaemia and the fat cow syndrome in cattle. PubMed
Liver Cirrhosis[Assessment of glutamic dehydrogenase activity in liver cirrhosis] PubMed
Liver Cirrhosis[Glutamate dehydrogenase in liver cirrhosis and liver stasis] PubMed
Liver Cirrhosis, AlcoholicHepatic activity and mRNA expression of aspartate aminotransferase isoenzymes in alcoholic and nonalcoholic liver disease. PubMed
Liver DiseasesAdaptation of methods for glutamate dehydrogenase and alcohol dehydrogenase activities to a centrifugal analyser: assessment of their clinical use in anoxic states of the liver. PubMed
Liver DiseasesBiochemical markers of chronic alcoholism. PubMed
Liver DiseasesField study of dairy cows with reduced appetite in early lactation: clinical examinations, blood and rumen fluid analyses. PubMed
Liver DiseasesIschemic preconditioning protects from hepatic ischemia/reperfusion-injury by preservation of microcirculation and mitochondrial redox-state. PubMed
Liver DiseasesMasking by enzyme inhibitor of raised serum glutamate dehydrogenase activity in Reye's syndrome. PubMed
Liver DiseasesMitochondrial enzyme activities in liver biopsies from patients with alcoholic liver disease. PubMed
Liver DiseasesMitochondrial enzymes in human serum: comparative determinations of glutamate dehydrogenase and mitochondrial aspartate aminotransferase in healthy persons and patients with chronic liver diseases. PubMed
Liver DiseasesMultivariate analysis of an enzymic profile for the differential diagnosis of viral hepatitis. PubMed
Liver DiseasesNephrotoxicity and hepatotoxicity in calves apparently caused by experimental feeding with Narthecium ossifragum. PubMed
Liver DiseasesThe diagnostic significance of liver cell inhomogeneity: serum enzymes in patients with central liver necrosis and the distribution of glutamate dehydrogenase in normal human liver. PubMed
Liver DiseasesThe effect of thioacetamide on urea cycle enzymes of rat liver. PubMed
Liver DiseasesThe mechanism of release of hepatic enzymes in various liver diseases. II. Altered activity ratios of GOT to GPT in serum and liver of patients with liver diseases. PubMed
Liver DiseasesThe mechanism of the release of hepatic enzymes in various liver diseases. 1. Alterations in cytoplasmic and mitochondrial enzyme activities in serum. PubMed
Liver Diseases[Activity of glutamic acid dehydrogenase in serum of patients with liver diseases] PubMed
Liver Diseases[Glutamate dehydrogenase activity in the blood serum in viral hepatitis and other liver diseases] PubMed
Liver Diseases[On the influence of surgery on the biliary system, especially in liver diseases, on the serum level of the enzymes sorbitol dehydrogenase, glutamic-pyruvic transaminase, lactate dehydrogenase and glutamic dehydrogenase.] PubMed
Liver Diseases, AlcoholicAdaptation of methods for glutamate dehydrogenase and alcohol dehydrogenase activities to a centrifugal analyser: assessment of their clinical use in anoxic states of the liver. PubMed
Liver Diseases, AlcoholicBiochemical markers of chronic alcoholism. PubMed
Liver Diseases, AlcoholicPlasma glutamate dehydrogenase: clinical application in patients with alcoholic liver disease. PubMed
Liver Diseases, AlcoholicSerum glutamate dehydrogenase as a marker of hepatocyte necrosis in alcoholic liver disease. PubMed
Liver Diseases, AlcoholicSerum glutamate dehydrogenase in alcoholic liver disease. PubMed
Liver Diseases, AlcoholicSerum level of ornithine carbamoyltransferase is influenced by the state of Kupffer cells. PubMed
Liver FailureHyperammonemia and hepatic encephalopathy stimulate rat cerebral synaptic mitochondrial glutamate dehydrogenase activity specifically in the direction of glutamate oxidation. PubMed
Liver Neoplasms[On the practical utility of determining in conjunction with transaminases the values of glutamate dehydrogenase in the blood of patients with cholostatic jaundice and primary or metastatic hepatic neoplasm] PubMed
Machado-Joseph DiseaseGlutamate and malate dehydrogenase activities in Joseph disease and olivopontocerebellar atrophy. PubMed
Machado-Joseph DiseaseGlutamate dehydrogenase deficiency in Machado-Joseph disease. PubMed
MalariaAbsence of alpha-ketoglutarate dehydrogenase activity and presence of CO2-fixing activity in Plasmodium falciparum grown in vitro in human erythrocytes. PubMed
MalariaChloroquine is a potent inhibitor of glutamate dehydrogenase in liver and kidney-cortex of rabbit. PubMed
MalariaDetection of glutamate dehydrogenase enzyme activity in Plasmodium falciparum infection. PubMed
MalariaGlutamate dehydrogenase antigen detection in Plasmodium falciparum infections. PubMed
MalariaGlutamate dehydrogenase, the marker protein of Plasmodium falciparum--cloning, expression and characterization of the malarial enzyme. PubMed
MalariaGlutathione reductase and glutamate dehydrogenase of Plasmodium falciparum, the causative agent of tropical malaria. PubMed
MalariaStudies on enzyme variation in the murine malaria parasites Plasmodium berghei, P. yoelii, P. vinckei and P. chabaudi by starch gel electrophoresis. PubMed
Malaria[Preparation of a monoclonal antibodies against Plasmodium falciparum glutamate dehydrogenase and establishment of colloidal gold-immunochromatographic assay] PubMed
Malaria, Falciparum[Preparation of a monoclonal antibodies against Plasmodium falciparum glutamate dehydrogenase and establishment of colloidal gold-immunochromatographic assay] PubMed
MalnutritionEffects of undernutrition and protein deficiency on glutamate dehydrogenase and decarboxylase in rat brain. PubMed
MalnutritionExpression of a bacterial aspartase gene in Aspergillus nidulans: an efficient system for selecting multicopy transformants. PubMed
MalnutritionThe Physical Functional Capacity of Frail Elderly Persons Undergoing Ambulatory Rehabilitation is Related to Their Nutritional Status. PubMed
Maple Syrup Urine DiseaseEnzymatic method for branched chain alpha-ketoacid determination: application to rapid analysis of urine and plasma samples from maple syrup urine disease patients. PubMed
Motor Neuron DiseaseGlutamate dehydrogenase and aspartate aminotransferase in leukocytes of patients with motor neuron disease. PubMed
Motor Neuron DiseaseLymphocyte glutamate dehydrogenase activity in normal aging and neurological diseases. PubMed
Multiple Sclerosis[Cerebral form of glutamate dehydrogenase activity in autonomic paroxysms (attacks of panic)] PubMed
Multiple System AtrophyCharacterization of glutamate dehydrogenase isoproteins purified from the cerebellum of normal subjects and patients with degenerative neurological disorders, and from human neoplastic cell lines. PubMed
Multiple System AtrophyGlutamate dehydrogenase deficiency in cerebellar degenerations: clinical, biochemical and molecular genetic aspects. PubMed
Multiple System AtrophyGlutamate dehydrogenase deficiency in Machado-Joseph disease. PubMed
Multiple System AtrophyLeukocyte glutamate dehydrogenase activity in patients with degenerative neurological disorders. PubMed
Multiple System AtrophyLow leukocyte glutamate dehydrogenase activity does not correlate with a particular type of multiple system atrophy. PubMed
Multiple System AtrophyNovel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene. PubMed
Myocardial InfarctionSystemic short-term fibrinolysis with high-dose streptokinase in acute myocardial infarction: time course of biochemical parameters. PubMed
Myocardial Infarction[Enzyme diagnosis of liver dysfunction in acute myocardial infarct and its complications] PubMed
Neoplasm MetastasisValue of alkaline phosphatase, 5'-nucleotidase, gamma-glutamyltransferase, and glutamate dehydrogenase activity measurements (single and combined) in serum in diagnosis of metastasis to the liver. PubMed
Neoplasm Metastasis[Evaluation of serum glutamic dehydrogenase activity in the diagnosis and treatment of hepatocellular carcinoma and liver metastasis] PubMed
NeoplasmsChanges in enzyme pattern of Ehrlich ascites tumor cells following serial cultivation in media with increased (hypertonic) NaCl content. PubMed
NeoplasmsClinical and pathological studies in horses with hepatic disease. PubMed
NeoplasmsEnzyme activities of six different dehydrogenases in Ehrlich ascites cells measured by flow cytometry. PubMed
NeoplasmsEnzyme pathology of the liver in patients with and without nonhepatic cancer. PubMed
NeoplasmsFlow-cytometric determination of dehydrogenase activities in primary human gastrointestinal tumor cell lines. PubMed
NeoplasmsGlutamic acid dehydrogenase and glutamic-oxalacetic transaminase of blood in leukemia and cancer. PubMed
NeoplasmsGREEN TEA POLYPHENOLS CONTROL DYSREGULATED GLUTAMATE DEHYDROGENASE IN TRANSGENIC MICE BY HIJACKING THE ADP ACTIVATION SITE. PubMed
NeoplasmsHepatic mitochondrial enzyme activity and serum amino acid composition in rats treated with tumor necrosis factor. PubMed
NeoplasmsIncreased susceptibility of carbamylated glutamate dehydrogenase to proteolysis. PubMed
NeoplasmsInfluence of formulation parameters on gadolinium entrapment and tumor cell uptake using folate-coated nanoparticles. PubMed
NeoplasmsL-carnitine could not improve hepatic warm ischemia-reperfusion injury despite ameliorated blood flow. PubMed
NeoplasmsProminent glutamine oxidation activity in mitochondria of avian transplantable hepatoma induced by MC-29 virus. PubMed
NeoplasmsShort-term metabolic fate of L-[13N]glutamate in the Walker 256 carcinosarcoma in vivo. PubMed
NeoplasmsSilibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupffer cells. PubMed
NeoplasmsThe pathway of glutamate oxidation in isolated mitochondria from the avian hepatomatous growth induced by MC-29 virus. PubMed
NeoplasmsValue of alkaline phosphatase, 5'-nucleotidase, gamma-glutamyltransferase, and glutamate dehydrogenase activity measurements (single and combined) in serum in diagnosis of metastasis to the liver. PubMed
Neoplasms[Oxidoreductase activity in the cells of stomach cancer] PubMed
Neoplasms[Studies of glutamate dehydrogenase activity in normal tissues and in malignant tumors] PubMed
Nervous System DiseasesCharacterization of glutamate dehydrogenase isoproteins purified from the cerebellum of normal subjects and patients with degenerative neurological disorders, and from human neoplastic cell lines. PubMed
Nervous System DiseasesDegenerative neurological disorders associated with deficiency of glutamate dehydrogenase. PubMed
Nervous System DiseasesFitting neurological protein aggregation kinetic data via a 2-step, minimal/'Ockham's razor' model: the Finke-Watzky mechanism of nucleation followed by autocatalytic surface growth. PubMed
Nervous System DiseasesGlutamate dehydrogenase deficiency in cerebellar degenerations: clinical, biochemical and molecular genetic aspects. PubMed
Nervous System DiseasesLeukocyte glutamate dehydrogenase activity in patients with degenerative neurological disorders. PubMed
Nervous System DiseasesLeukocyte glutamate dehydrogenase in patients with degenerative neurological disorders. PubMed
Nervous System DiseasesLevels of glutamic acid decarboxylase (GAD), gamma amino butyric acid transaminase (GABA-T), glutamic acid dehydrogenase (GLDH) and proteins in cerebrospinal fluid of certain neurological disorders. PubMed
Nervous System DiseasesNeurological aspects of hyperinsulinism-hyperammonaemia syndrome. PubMed
Nervous System DiseasesNeurological disorders associated with deficiency of glutamate dehydrogenase. PubMed
Nervous System DiseasesNovel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene. PubMed
NeuroblastomaHuman GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum. PubMed
NeuroblastomaSmall-interfering-RNA-mediated silencing of human glutamate dehydrogenase induces apoptosis in neuroblastoma cells. PubMed
Neurodegenerative DiseasesActivation of two types of brain glutamate dehydrogenase isoproteins by gabapentin. PubMed
Neurodegenerative DiseasesCellular and regional expression of glutamate dehydrogenase in the rat nervous system: non-radioactive in situ hybridization and comparative immunocytochemistry. PubMed
Neurodegenerative DiseasesDifferential Levels of Glutamate Dehydrogenase 1 (GLUD1) in BALB/c and C57BL/6 Mice and the Effects of Over-Expression of Glud1 Gene on Glutamate Release in Striatum. PubMed
Neurodegenerative DiseasesRegional distribution of astrocytes with intense immunoreactivity for glutamate dehydrogenase in rat brain: implications for neuron-glia interactions in glutamate transmission. PubMed
Neurodegenerative DiseasesThe human GLUD2 glutamate dehydrogenase and its regulation in health and disease. PubMed
Neurodegenerative DiseasesUnaltered cytochrome oxidase, glutamate dehydrogenase and glutaminase activities in platelets from patients with sporadic amyotrophic lateral sclerosis--a study of potential pathogenetic mechanisms in neurodegenerative diseases. PubMed
Odontogenic CystsOdontogenic keratocysts: a clinical and histological study with special reference to enzyme histochemistry. PubMed
Olivopontocerebellar AtrophiesAbnormal glutamate metabolism in an adult-onset degenerative neurological disorder. PubMed
Olivopontocerebellar AtrophiesAbnormal platelet glutamate dehydrogenase activity and activation in dominant and nondominant olivopontocerebellar atrophy. PubMed
Olivopontocerebellar AtrophiesAbnormalities of mitochondrial enzymes in hereditary ataxias. PubMed
Olivopontocerebellar AtrophiesCerebellar glutamate metabolizing enzymes in spinocerebellar ataxia type I. PubMed
Olivopontocerebellar AtrophiesDegenerative neurological disorders associated with deficiency of glutamate dehydrogenase. PubMed
Olivopontocerebellar AtrophiesGlutamate and malate dehydrogenase activities in Joseph disease and olivopontocerebellar atrophy. PubMed
Olivopontocerebellar AtrophiesGlutamate dehydrogenase and its isozyme activity in olivopontocerebellar atrophy. PubMed
Olivopontocerebellar AtrophiesGlutamate dehydrogenase deficiency in patients with olivopontocerebellar atrophy. PubMed
Olivopontocerebellar AtrophiesGlutamate dehydrogenase deficiency in spinocerebellar degenerations. PubMed
Olivopontocerebellar AtrophiesGlutamate dehydrogenase in olivopontocerebellar atrophies: leukocytes, fibroblasts, and muscle mitochondria. PubMed
Olivopontocerebellar AtrophiesLow leukocyte glutamate dehydrogenase activity does not correlate with a particular type of multiple system atrophy. PubMed
Olivopontocerebellar AtrophiesLymphocyte glutamate dehydrogenase activity in normal aging and neurological diseases. PubMed
Olivopontocerebellar AtrophiesMultiple system degeneration with glutamate dehydrogenase deficiency: pathology and biochemistry. PubMed
Olivopontocerebellar AtrophiesNeurological disorders associated with deficiency of glutamate dehydrogenase. PubMed
Olivopontocerebellar AtrophiesNeurophysiologic study of olivopontocerebellar atrophy with or without glutamate dehydrogenase deficiency. PubMed
Olivopontocerebellar AtrophiesOlivopontocerebellar atrophy with retinal degeneration. An electroretinographic and histopathologic investigation. PubMed
Olivopontocerebellar AtrophiesOral glutamate loading in disorders with spinocerebellar and extrapyramidal involvement: effect on plasma glutamate, aspartate and taurine. PubMed
Olivopontocerebellar AtrophiesPathology of olivopontocerebellar atrophy with glutamate dehydrogenase deficiency. PubMed
Pain[Expression of the paternal genes for lactate dehydrogenase, glutamate dehydrogenase and acetylcholinesterase in the development of hybrid fish between species from the families of Cobitidae and Cyprinidae] PubMed
Pancreatic NeoplasmsFlow-cytometric determination of dehydrogenase activities in primary human gastrointestinal tumor cell lines. PubMed
Pancreatitis[Glutamate dehydrogenase activity in the pancreatic tissue in acute experimental pancreatitis and under the action of sodium thiosulphate] PubMed
ParalysisGlutamate dehydrogenase (GDH) deficiency in different types of progressive hereditary cerebellar ataxia. PubMed
Parkinson DiseaseGain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset. PubMed
Parkinson DiseaseLeukocyte glutamate dehydrogenase activity in patients with degenerative neurological disorders. PubMed
Parkinson DiseaseLymphocyte glutamate dehydrogenase activity in normal aging and neurological diseases. PubMed
Parkinson DiseaseThe human GLUD2 glutamate dehydrogenase and its regulation in health and disease. PubMed
Parkinson Disease[Cytochemical activity of mitochondrial enzymes in Parkinson's disease] PubMed
Parkinsonian DisordersDecreased glutamate dehydrogenase protein in spinocerebellar degeneration. PubMed
Parkinsonian DisordersGlutamate dehydrogenase deficiency in patients with olivopontocerebellar atrophy. PubMed
Parkinsonian DisordersLeukocyte glutamate dehydrogenase activity in patients with degenerative neurological disorders. PubMed
Parkinsonian DisordersRehabilitation outcomes of older patients at 6 months follow-up after discharged from a geriatric day hospital (GDH). PubMed
Periodontitis[Activity of glutamate dehydrogenase, gamma-glutamyltranspeptidase and creatine kinase in saliva in gingivitis] PubMed
Peripheral Nervous System DiseasesGlutamate dehydrogenase deficiency in patients with olivopontocerebellar atrophy. PubMed
Protein DeficiencyEffects of undernutrition and protein deficiency on glutamate dehydrogenase and decarboxylase in rat brain. PubMed
Pyelonephritis[Glutamic dehydrogenase activities in renal tissue during experimental and human ehronie pyelonephritis (author's transl)] PubMed
Reye SyndromeAbsence of diffusible inhibitor of glutamate dehydrogenase in the hepatocytes of Reye syndrome patients. PubMed
Reye SyndromeEffects of peroxidized polyunsaturated fatty acids on mitochondrial function and structure: pathogenetic implications for Reye's syndrome. PubMed
Reye SyndromeGlutamate dehydrogenase in Reye's syndrome. Evidence for the presence of an altered enzyme in serum with increased susceptibility to inhibition by GTP. PubMed
Reye SyndromeMasking by enzyme inhibitor of raised serum glutamate dehydrogenase activity in Reye's syndrome. PubMed
Reye SyndromeQuantitative evaluation of the extent of hepatic enzyme changes in Reye syndrome compared with normal liver or with non-Reye liver disorders: objective criteria for animal models. PubMed
Reye SyndromeSerum glutamate dehydrogenase and ornithine carbamyl transferase in Reye's syndrome. PubMed
SarcoidosisLactate, malate and glutamate dehydrogenase activity in mediastinal lymph nodes in sarcoidosis. PubMed
Sarcoma, YoshidaEffects of glutamate dehydrogenase, choline oxidase, and glucose-6-phosphatase on 67Ga accumulation in lysosome. PubMed
SchistosomiasisSerum isocitric dehydrogenase and glutamic dehydrogenase in schistosomiasis. PubMed
Schistosomiasis mansoniSerum enzyme tests in hepatosplenic schistosomiasis. PubMed
SeizuresAnticonvulsant drugs, brain glutamate dehydrogenase activity and oxygen consumption. PubMed
SeizuresBiochemical evaluation of an infant with hypoglycemia resulting from a novel de novo mutation of the GLUD1 gene and hyperinsulinism-hyperammonemia syndrome. PubMed
SeizuresCentral nervous system hyperexcitability associated with glutamate dehydrogenase gain of function mutations. PubMed
SeizuresDifferential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy. PubMed
SeizuresEffect of vigabatrin on glutamate dehydrogenase in the hippocampus of seizure prone gerbils. PubMed
SeizuresEffects of acute hyperammonemia in vivo on oxidative metabolism in nonsynaptic rat brain mitochondria. PubMed
SeizuresNeurological aspects of hyperinsulinism-hyperammonaemia syndrome. PubMed
Seizures[Metabolic investigations of epileptic seizures: the role of aminotransferases and glutamate dehydrogenase in convulsions] PubMed
Sexually Transmitted DiseasesPopulation genetics of Neisseria gonorrhoeae in a high-prevalence community using a hypervariable outer membrane porB and 13 slowly evolving housekeeping genes. PubMed
Spinal Cord IschemiaPreventive effects of intrathecal methylprednisolone administration on spinal cord ischemia in rats: the role of excitatory amino acid metabolizing systems. PubMed
Spinocerebellar AtaxiasCerebellar glutamate metabolizing enzymes in spinocerebellar ataxia type I. PubMed
Spinocerebellar AtaxiasDecreased glutamate dehydrogenase protein in spinocerebellar degeneration. PubMed
Spinocerebellar AtaxiasGlutamate dehydrogenase deficiency in three patients with spinocerebellar ataxia: a new enzymatic defect? PubMed
Spinocerebellar AtaxiasGlutamate dehydrogenase deficiency in three patients with spinocerebellar syndrome. PubMed
Spinocerebellar DegenerationsDecreased glutamate dehydrogenase protein in spinocerebellar degeneration. PubMed
Spinocerebellar DegenerationsGlutamate dehydrogenase deficiency in Machado-Joseph disease. PubMed
Spinocerebellar DegenerationsGlutamate dehydrogenase deficiency in spinocerebellar degenerations. PubMed
Spinocerebellar DegenerationsGlutamate metabolism of leukocytes and skin fibroblasts in spinocerebellar degeneration with lowered glutamate dehydrogenase activity. PubMed
Spinocerebellar DegenerationsLeucocyte glutamate dehydrogenase in various hereditary ataxias. PubMed
Spinocerebellar DegenerationsLow leukocyte glutamate dehydrogenase activity does not correlate with a particular type of multiple system atrophy. PubMed
Spinocerebellar DegenerationsNormal cerebellar glutamate dehydrogenase protein in spinocerebellar degeneration. PubMed
Spinocerebellar DegenerationsPartially deficient glutamate dehydrogenase activity and attenuated oscillatory potentials in patients with spinocerebellar degeneration. PubMed
Spinocerebellar Degenerations[Dual nature of excitatory amino acids in the vertebrate retina] PubMed
Spinocerebellar Degenerations[Glutamate dehydrogenase and its isozyme activity in spinocerebellar degeneration] PubMed
StarvationAmino-acid metabolism enzyme activities in rat white adipose tissue. PubMed
StarvationChanges in Viability, Cell Composition, and Enzyme Levels During Starvation of Continuously Cultured (Ammonia-Limited) Selenomonas ruminantium. PubMed
StarvationDistinctive properties and expression profiles of glutamine synthetase from a plant symbiotic fungus. PubMed
StarvationEffect of 24-hour starvation on amino acid pool composition and enzyme activities of rat brown adipose tissue. PubMed
StarvationEffect of glucose starvation on the nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase of yeast. PubMed
StarvationGlutamate deamination by glutamate dehydrogenase plays a central role in amino acid catabolism in plants. PubMed
StarvationLong-term nutritional effects on the primary liver and kidney metabolism in rainbow trout. Adaptive response to starvation and a high-protein, carbohydrate-free diet on glutamate dehydrogenase and alanine aminotransferase kinetics. PubMed
StarvationMetabolic pathways of ammoniogenesis in the shrimp Crangon crangon L.: possible role of glutamate dehydrogenase. PubMed
StarvationMuliple sites of action of cycloheximide in addition to inhibition of protein synthesis in Physarum polycephalum. PubMed
StarvationMutation-induced metabolite pool alterations in Corynebacterium glutamicum: towards the identification of nitrogen control signals. PubMed
StarvationNAD(H)-dependent glutamate dehydrogenase is essential for the survival of Arabidopsis thaliana during dark-induced carbon starvation. PubMed
StarvationNew insights towards the function of glutamate dehydrogenase revealed during source-sink transition of tobacco (Nicotiana tabacum) plants grown under different nitrogen regimes. PubMed
StarvationPhosphorylation of NAD-dependent glutamate dehydrogenase from yeast. PubMed
StarvationRegulation of Saccharomyces cerevisiae nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase by proteolysis during carbon starvation. PubMed
StarvationStress-induced changes in glutamate dehydrogenase activity imply its role in adaptation to C and N metabolism in lupine embryos. PubMed
StarvationThe dynamics of local kinetic parameters of glutamate dehydrogenase in rat liver. PubMed
StarvationThe influence of high dietary protein, energy and mineral intake on deficient young camel (Camelus dromedarius)--I. Changes in metabolic profiles and growth performance. PubMed
StarvationThe two-component, ATP-dependent Clp protease of Escherichia coli. Purification, cloning, and mutational analysis of the ATP-binding component. PubMed
Stomach NeoplasmsFlow-cytometric determination of dehydrogenase activities in primary human gastrointestinal tumor cell lines. PubMed
Striatonigral DegenerationLow leukocyte glutamate dehydrogenase activity does not correlate with a particular type of multiple system atrophy. PubMed
Stroke[Geriatric day hospital: what evidence? A systematic review]. PubMed
Subacute Sclerosing PanencephalitisPromoter specificity of sigma G-containing RNA polymerase from sporulating cells of Bacillus subtilis: identification of a group of forespore-specific promoters. PubMed
sulfite oxidase deficiencyA mechanism of sulfite neurotoxicity: direct inhibition of glutamate dehydrogenase. PubMed
Supranuclear Palsy, ProgressiveLeukocyte glutamate dehydrogenase activity in patients with degenerative neurological disorders. PubMed
TauopathiesIdentification of non-Alzheimer's disease tauopathies-related proteins by proteomic analysis. PubMed
Thiamine DeficiencyPhysiological studies on the effects of nutritional imbalance on the central nervous system. II. Effects of thiamine deficiency on oxidative enzymes in the brain of chicken, Gallus domesticus. PubMed
ThrombocytopeniaNTP Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). PubMed
Thyrotoxicosis[Effect of experimental changes in thyroid function on oxidative metabolism and glutamate dehydrogenase activity in the limbic system of the rat] PubMed
TuberculosisThe gdhB gene of Pseudomonas aeruginosa encodes an arginine-inducible NAD(+)-dependent glutamate dehydrogenase which is subject to allosteric regulation. PubMed
Typhoid Fever[Enzymatic activity in the lung cells to the intrapulmonary administration of antigen] PubMed
Typhoid Fever[The effect of lipids from typhoid endotoxin on the activity of some liver enzymes] PubMed
Vitamin E DeficiencyCombined vitamin E deficiency and ethanol pretreatment: liver glutathione and enzyme changes. PubMed

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISMLINK TO PUBMEDSOURCE
391451Schmidt, C.N.G.; Jervis, L.Partial purification and characterization of glutamate synthase from a thermophilic bacillusJ. Gen. Microbiol.1281713-17181982Geobacillus stearothermophilus-
391453Nisbet, B.A.; Slaughter, J.C.Glutamate dehydrogenase and glutamate synthase from the yeast Kluyveromyces fragilis: Variability in occurrence and propertiesFEMS Microbiol. Lett.7319-3211980Kluyveromyces marxianus-
391541Smith, E.L.; Austen, B.M.; Blumenthal, K.M.; Nyc, J.F.Glutamate dehydrogenaseThe Enzymes, 3rd Ed. (Boyer, P.D., ed.)11293-3671975Achlya sp., Apodachlya sp., Blastocladiella emersonii, Clostridium sp., Micrococcus aerogenes, Neurospora crassa, Peptoniphilus asaccharolyticus, Pisum sativum, Pythium debaryanum, Saccharomyces cerevisiae, Starkeya novella-
391542Chavez, S.; Candau, P.An NAD-specific glutamate dehydrogenase from cyanobacteria. Identification and propertiesFEBS Lett.28535-381991Synechocystis sp. PubMed
391543Stone, S.R.; Copeland, L.; Heyde, E.Glutamate dehydrogenase of lupin nodules: kinetics of the deamination reactionArch. Biochem. Biophys.199550-5591980Lupinus luteus PubMed
391544Higa, A.I.; de Cazzulo, B.M.F.; Cazzulo, J.J.Some properties of the NAD-specific glutamate dehydrogenase from Crithidia fasciculataJ. Gen. Microbiol.113429-4321979Crithidia fasciculata-
391545Meredith, M.J.; Gronostajski, R.M.; Schmidt, R.R.Physical and kinetic properties of the nicotinamide adenine dinucleotide-specific glutamate dehydrogenase purified from Chlorella sorokinianaPlant Physiol.61967-9741978Chlorella sorokiniana PubMed
391546Garland, W.J.; Dennis, D.T.Steady-state kinetics of glutamate dehydrogenase from Pisum sativum L. mitochondriaArch. Biochem. Biophys.182614-6251977Pisum sativum PubMed
391547Stone, S.R.; Copeland, L.; Kennedy, I.R.Glutamate dehydroenase of lupin nodules: Purification and propertiesPhytochemistry181273-12781979Lupinus luteus-
391548Syed, S.E.H.; Engel, P.C.; Parker, D.M.Functional studies of a glutamate dehydrogenase with known three-dimensional structure: steady-state kinetics of the forward and reverse reactions catalysed by the NAD(+)-dependent glutamate dehydrogenase of Clostridium symbiosumBiochim. Biophys. Acta1115123-1301991Clostridium symbiosum PubMed
391549Pamula, F.; Wheldrake, J.F.The NAD-dependent glutamate dehydrogenase from Dictyostelium discoideum: purification and propertiesArch. Biochem. Biophys.291225-2301991Dictyostelium discoideum PubMed
391550Strickland, W.N.; Jacobson, J.W.; Strickland, M.The amino acid composition and some properties of the NAD+-specific glutamate dehydrogenase from Neurospora crassaBiochim. Biophys. Acta25121-301991Neurospora crassa-
391551Johnson, W.M.; Westlake, D.W.S.Purification and characterization of glutamic acid dehydrogenase and alpha-ketoglutaric acid reductase from Peptococcus aerogenesCan. J. Microbiol.18881-8921972Peptoniphilus asaccharolyticus PubMed
391552Veronese, F.M.; Nyc, J.F.; Degani, Y.; Brown, D.M.; Smith, E.L.Nicotinamide adenine dinucleotide-specific glutamate dehydrogenase of Neurospora. I. Purification and molecular propertiesJ. Biol. Chem.2497922-79281974Neurospora crassa PubMed
391553Fawole, M.O.; Boulter, D.Purification and properties of glutamate dehydrogenase from Vigna unguiculata (L.) Walp.Planta13497-1021977Vigna unguiculata-
391554Ruano, A.R.; Riano, J.L.A.; Amil, M.R.; Santos, M.J.H.Some enzymatic properties of NAD+-dependent glutamate dehydrogenase of mussel hepatopancreas (Mytilus edulis L.) requirement of ADPComp. Biochem. Physiol. B82197-2021985Mytilus edulis-
391555Verma, N.S.; Sharma, D.; Gollakota, K.G.Purification & properties of isozymes of glutamate dehydrogenase form Bacillus cereus TIndian J. Biochem. Biophys.13344-3461976Bacillus cereus PubMed
391556Grover, A.K.; Kapoor, M.Studies on the regulation, subunit structure, and some properties of NAD-specific glutamate dehydrogenase of NeurosporaJ. Exp. Bot.24847-8611973Neurospora crassa-
391557Batrel, Y.; Le Gal, Y.Nitrogen metabolism in Arenicola marina. Characterization of a NAD dependent glutamate dehydrogenaseComp. Biochem. Physiol. B78119-1241984Arenicola marina-
391558Storey, K.B.; Fields, J.H.A.; Hochachka, P.W.Purification and properties of glutamate dehydrogenase from the mantle muscle of the squid, Loligo pealeii. Role of the enzyme in energy production from amino acidsJ. Exp. Zool.205111-1181978Doryteuthis pealeii PubMed
391559Dudler, N.; Miller, D.J.Characterization of two glutamate dehydrogenases from the symbiotic microalga Symbiodinium microadriaticum isolated from the coral Acropora formosaMar. Biol.97427-4301988Symbiodinium microadriaticum-
391560Singh, U.S.; Rao, V.K.M.Characterization of L-glutamate dehydrogenase activity of axenically grown Acanthamoeba culbertsoniIndian J. Biochem. Biophys.20146-1481983Acanthamoeba culbertsoni PubMed
391561Loulakakis, C.A.; Roubelakis-Angelakis, K.A.Intracellular localization and properties of NADH-glutamate dehydrogenase from Vitis vinifera L.: Purification and characterization of the major leaf isoenzymeJ. Exp. Bot.411223-12301990Vitis vinifera-
391562Ramirez, H.; Delgado, M.J.; Garcia-Peregrin, E.Some properties of glutamate dehydrogenase from Agave americana L. leavesZ. Pflanzenphysiol.84109-1191977Agave americana-
391564Van Laere, A.J.Purification and properties of NAD-dependent glutamate dehydrogenase from Phycomyces sporesJ. Gen. Microbiol.1341597-16011988Phycomyces blakesleeanus PubMed
391566Hammer, B.A.; Johnson, E.A.Purification, properties, and metabolic roles of NAD+-glutamate dehydrogenase in Clostridium botulinum 113BArch. Microbiol.150460-4641988Clostridium botulinum PubMed
391567Stevens, L.; Duncan, D.; Robertson, P.Purification and characterisation of NAD-glutamate dehydrogenase from Aspergillus nidulansFEMS Microbiol. Lett.57173-1781989Emericella nidulans PubMed
391568Scheid, H.W.; Ehmke, A.; Hartmann, T.Plant NAD-dependent glutamate dehydrogenase. Purification, molecular properties and metal ion activation of the enzymes from Lemna minor and Pisum sativumZ. Naturforsch. C35213-2211980Lemna minor, Pisum sativum-
391569Nagel, M.; Hartmann, T.Glutamate dehydrogenase from Medicago sativa L., purification and comparative kinetic studies of the organ-specific multiple formsZ. Naturforsch. C35406-4151980Medicago sativa PubMed
391570Hemmings, B.A.Purification and properties of the phospho and dephospho forms of yeast NAD-dependent glutamate dehydrogenaseJ. Biol. Chem.2557925-79321980Cyberlindnera jadinii PubMed
391571Hornby, D.P.; Engel, P.C.Characterization of Peptostreptococcus asaccharolyticus glutamate dehydrogenase purified by dye-ligand chromatographyJ. Gen. Microbiol.1302385-23941984Peptoniphilus asaccharolyticus PubMed
391572Yamaya, T.; Oaks, A.; Matsumoto, H.Characteristics of glutamate dehydrogenase in mitochondria prepared from corn shootsPlant Physiol.761009-10131984Zea mays PubMed
391573El-Shora, H.M.; Abo-Kassem, E.M.Kinetic characterization of glutamate dehydrogenase of marrow cotyledonsPlant Sci.1611047-10532001Cucurbita pepo-
391574Schlee, D.; Thoeringer, C.; Tintemann, H.Purification and properties of glutamate dehydrogenase in Scots pine (Pinus sylvestris) needlesPhysiol. Plant.92467-4721994Pinus sylvestris-
391575Anderson, B.M.; Anderson, C.D.; Van Tassell, R.L.; Lyerly, D.M.; Wilkins, T.D.Purification and characterization of Clostridium difficile glutamate dehydrogenaseArch. Biochem. Biophys.300483-4881993Clostridium difficile PubMed
391576Pasquo, A.; Britton, K.L.; Stillman, T.J.; Rice, D.W.; Coelfen, H.; Harding, S.E.; Scandurra, R.; Engel, P.C.Construction of a dimeric form of glutamate dehydrogenase from Clostridium symbiosum by site-directed mutagenesisBiochim. Biophys. Acta1297149-1581996Clostridium symbiosum PubMed
391577Abrahams, G.L.; Iles, K.D.; Abratt, V.R.The Bacteroides fragilis NAD-specific glutamate dehydrogenase enzyme is cell surface-associated and regulated by peptides at the protein levelAnaerobe7135-1422001Bacteroides fragilis-
391578Consalvi, V.; Chiaraluce, R.; Millevoi, S.; Pasquo, A.; Politi, L.; De Rosa, M.; Scandurra, R.NAD-dependent glutamate dehydrogenase from the thermophilic eubacterium Bacillus acidocaldariusComp. Biochem. Physiol. B109691-6991994Alicyclobacillus acidocaldarius-
391579Camardella, L.; Di Fraia, R.; Antignani, A.; Ciardiello, M.A.; di Prisco, G.; Coleman, J.K.; Buchon, L.; Guespin, J.; Russell, N.J.The Antarctic Psychrobacter sp. TAD1 has two cold-active glutamate dehydrogenases with different cofactor specificities. Characterisation of the NAD+-dependent enzymeComp. Biochem. Physiol. A131559-567.2002Psychrobacter sp. PubMed
391580Jahns, T.; Kaltwasser, H.Purification and properties of a heat-stable and cold-labile NAD-specific glutamate dehydrogenase from Sporosarcina ureaeArch. Microbiol.161531-5341994Sporosarcina ureae-
391581Kersten, M.A.S.H.; Muller, Y.; Baars, J.J.P.; Op den Camp, H.J.M.; Van der Drift, C.; Van Griensven, L.J.L.D.; Visser, J.; Schaap, P.J.NAD+-dependent glutamate dehydrogenase of the edible mushroom Agaricus bisporus: biochemical and molecular characterizationMol. Gen. Genet.261452-4621999Agaricus bisporus PubMed
391582Jongsareejit, B.; Fujiwara, S.; Takagi, M.; Imanaka, T.Comparison of two glutamate producing enzymes from the hyperthermophilic archaeon Pyrococcus sp. KOD1FEMS Microbiol. Lett.158243-2481998Pyrococcus sp.-
391583Garnier, A.; Berredjem, A.; Botton, B.Purification and characterization of the NAD-dependent glutamate dehydrogenase in the ectomycorrhizal fungus Laccaria bicolor (Maire) OrtonFungal Genet. Biol.22168-1761997Laccaria bicolor PubMed
391584Ruiz, J.L.; Ferrer, J.; Camacho, M.; Bonete, M.J.NAD-specific glutamate dehydrogenase from Thermus thermophilus HB8: purification and enzymic propertiesFEMS Microbiol. Lett.15915-201998Thermus thermophilus-
391585Pamula, F.; Wheldrake, J.F.Kinetic properties and the mechanism of activation of NAD-dependent glutamate dehydrogenase from Dictyostelium discoideumBiochem. Mol. Biol. Int.38729-738.1996Dictyostelium discoideum PubMed
391586Minambres, B.; Olivera, E.R.; Jensen, R.A.; Luengo, J.M.A new class of glutamate dehydrogenases (GDH)J. Biol. Chem.27539529-395422000Streptomyces clavuligerus PubMed
391587Nguyen, K.T.; Nguyen, L.T.; Kopecky, J.; Behal, V.Properties of NAD-dependent glutamate dehydrogenase from the tylosin producer Streptomyces fradiaeCan. J. Microbiol.431005-10101997Streptomyces fradiae-
391588Jahns, T.Unusually stable NAD-specific glutamate dehydrogenase from the alkaliphile Amphibacillus xylanusAntonie Leeuwenhoek7089-951996Amphibacillus xylanus PubMed
391589Kujo, C.; Ohshima, T.Enzymological characteristics of the hyperthermostable NAD-dependent glutamate dehydrogenase from the archaeon Pyrobaculum islandicum and effects of denaturants and organic solventsAppl. Environ. Microbiol.642152-21571998Pyrobaculum islandicum PubMed
391590Lebbink, J.H.; Knapp, S.; van der Oost, J.; Rice, D.; Ladenstein, R.; de Vos, W.M.Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. II: construction of a 16-residue ion-pair network at the subunit interfaceJ. Mol. Biol.289357-3691999Thermotoga maritima PubMed
391591Cho, S.W.; Lee, J.; Choi, S.Y.Two soluble forms of glutamate dehydrogenase isoproteins from bovine brainEur. J. Biochem.233340-3461995Bos taurus PubMed
391629Jahns, T.; Kaltwasser, H.Properties of the cold-labile NAD+-specific glutamate dehydrogenase from Bacillus cereus DSM 31J. Gen. Microbiol.139775-7801993Bacillus cereus PubMed
655253Camardella, L.; di Fraia, R.; Antignani, A.; Ciardiello, M.A.; di Prisco, G.; Coleman, J.K.; Buchon, L.; Guespin, J.; Russell, N.J.The antarctic Psychrobacter sp. TAD1 has two cold-active glutamate dehydrogenases with different cofactor specificities. Characterisation of the NAD+-dependent enzymeComp. Biochem. Physiol. A131A559-5672002Psychrobacter sp.-
655606Hayden, B.M.; Bonete, M.J.; Brown, P.E.; Moir, A.J.; Engel, P.C.Glutamate dehydrogenase of Halobacterium salinarum: evidence that the gene sequence currently assigned to the NADP+-dependent enzyme is in fact that of the NAD+-dependent glutamate dehydrogenaseFEMS Microbiol. Lett.21137-412002Halobacterium salinarum PubMed
655623Bonete, M.J.; Perez-Pomares, F.; Diaz, S.; Ferrer, J.; Oren, A.Occurrence of two different glutamate dehydrogenase activities in the halophilic bacterium Salinibacter ruberFEMS Microbiol. Lett.226181-1862003Salinibacter ruber PubMed
655641Carrigan, J.B.; Coughlan, S.; Engel, P.C.Properties of the thermostable glutamate dehydrogenase of the mesophilic anaerobe Peptostreptoccus asaccharolyticus purified by a novel method after over-expression in an Escherichia coli hostFEMS Microbiol. Lett.24453-592005Peptoniphilus asaccharolyticus PubMed
656115Aghajanian, S.; Hovsepyan, M.; Geoghegan, K.F.; Chrunyk, B.A.; Engel, P.C.A thermally sensitive loop in clostridial glutamate dehydrogenase detected by limited proteolysisJ. Biol. Chem.2781067-10742003Clostridium symbiosum PubMed
656554Bhuiya, M.W.; Sakuraba, H.; Ohshima, T.; Imagawa, T.; Katunuma, N.; Tsuge, H.The first crystal structure of hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicumJ. Mol. Biol.345325-3372005Pyrobaculum islandicum PubMed
656633Ruiz, J.L.; Ferrer, J.; Pire, C.; Llorca, F.I.; Bonete, M.J.Denaturation studies by fluorescence and quenching of thermophilic protein NAD+-glutamate dehydrogenase from Thermus thermophilus HB8J. Protein Chem.22295-3012003Thermus thermophilus PubMed
657131Paczek, V.; Dubois, F.; Sangwan, R.; Morot-Gaudry, J.F.; Roubelakis-Angelakis, K.A.; Hirel, B.Cellular and subcellular localisation of glutamine synthetase and glutamate dehydrogenase in grapes gives new insights on the regulation of carbon and nitrogen metabolismPlanta216245-2542002Vitis vinifera PubMed
661800Joannou, C.L.; Brown, P.R.NAD-dependent glutamate dehydrogenase from Pseudomonas aeruginosa is a membrane-bound enzymeFEMS Microbiol. Lett.69205-2091992Pseudomonas aeruginosa PubMed
663075Kichey, T.; Le Gouis, J.; Sangwan, B.; Hirel, B.; Dubois, F.Changes in the cellular and subcellular localization of glutamine synthetase and glutamate dehydrogenase during flag leaf senescence in wheat (Triticum aestivum L.)Plant Cell Physiol.46964-9742005Triticum aestivum PubMed
670544Abiko, T.; Obara, M.; Ushioda, A.; Hayakawa, T.; Hodges, M.; Yamaya, T.Localization of NAD-isocitrate dehydrogenase and glutamate dehydrogenase in rice roots: candidates for providing carbon skeletons to NADH-glutamate synthasePlant Cell Physiol.461724-17342005Oryza sativa PubMed
671178Kwinta, J.; Kozlik, D.Glutamine synthetase and glutamate dehydrogenase in cadmium-stressed triticale seedlingsActa Physiol. Plant.28339-3472006Triticum aestivum-
671995Goda, S.; Kojima, M.; Nishikawa, Y.; Kujo, C.; Kawakami, R.; Kuramitsu, S.; Sakuraba, H.; Hiragi, Y.; Ohshima, T.Intersubunit interaction induced by subunit rearrangement is essential for the catalytic activity of the hyperthermophilic glutamate dehydrogenase from Pyrobaculum islandicumBiochemistry4415304-153132005Pyrobaculum islandicum PubMed
672020Paradisi, F.; Dean, J.L.; Geoghegan, K.F.; Engel, P.C.Spontaneous chemical reversion of an active site mutation: deamidation of an asparagine residue replacing the catalytic aspartic acid of glutamate dehydrogenaseBiochemistry443636-36432005Clostridium symbiosum PubMed
672660Khan, I.H.; Kim, H.; Ashida, H.; Ishikawa, T.; Shibata, H.; Sawa, Y.Altering the substrate specificity of glutamate dehydrogenase from Bacillus subtilis by site-directed mutagenesisBiosci. Biotechnol. Biochem.691802-18052005Bacillus subtilis PubMed
672661Khan, M.I.; Ito, K.; Kim, H.; Ashida, H.; Ishikawa, T.; Shibata, H.; Sawa, Y.Molecular properties and enhancement of thermostability by random mutagenesis of glutamate dehydrogenase from Bacillus subtilisBiosci. Biotechnol. Biochem.691861-18702005Bacillus subtilis PubMed
672773Baclayon, D.P.; Matsui, T.; Suzuki, H.; Kosugi, Y.Cloning, sequencing and expression analysis of a cDNA encoding glutamate dehydrogenase gene in broccoli during postharvest senescenceBiotechnology5118-1242006Brassica oleracea-
673480Lee, K.H.; Huh, J.W.; Choi, M.M.; Yoon, S.Y.; Yang, S.J.; Hong, H.N.; Cho, S.W.Regulation of glutamate level in rat brain through activation of glutamate dehydrogenase by Corydalis ternataExp. Mol. Med.37371-3772005Homo sapiens, Rattus norvegicus PubMed
673495Diaz, S.; Perez-Pomares, F.; Pire, C.; Ferrer, J.; Bonete, M.J.Gene cloning, heterologous overexpression and optimized refolding of the NAD-glutamate dehydrogenase from Haloferax mediterraneiExtremophiles10105-1152006Haloferax mediterranei PubMed
673612Paradisi, F.; Woolfson, R.; Geoghegan, K.F.; Engel, P.C.Identification of the residue responsible for catalysing regeneration of activity in the inactive glutamate dehydrogenase mutant D165NFEBS Lett.5792830-28322005Clostridium symbiosum PubMed
673715Newbold, C.J.; McEwan, N.R.; Calza, R.E.; Chareyron, E.N.; Duval, S.M.; Eschenlauer, S.C.; McIntosh, F.M.; Nelson, N.; Travis, A.J.; Wallace, R.J.An NAD(+)-dependent glutamate dehydrogenase cloned from the ruminal ciliate protozoan, Entodinium caudatumFEMS Microbiol. Lett.247113-1212005Entodinium caudatum PubMed
673970Gupta, P.; Gadre, R.Increase in NADH-glutamate dehydrogenase activity by mercury in excised bean leaf segmentsIndian J. Exp. Biol.43824-8282005Phaseolus vulgaris PubMed
674303Saum, S.H.; Sydow, J.F.; Palm, P.; Pfeiffer, F.; Oesterhelt, D.; Mueller, V.Biochemical and molecular characterization of the biosynthesis of glutamine and glutamate, two major compatible solutes in the moderately halophilic bacterium Halobacillus halophilusJ. Bacteriol.1886808-68152006Halobacillus halophilus PubMed
675147Pageau, K.; Reisdorf-Cren, M.; Morot-Gaudry, J.F.; Masclaux-Daubresse, C.The two senescence-related markers, GS1 (cytosolic glutamine synthetase) and GDH (glutamate dehydrogenase), involved in nitrogen mobilization, are differentially regulated during pathogen attack and by stress hormones and reactive oxygen species in Nicotiana tabcum L. leavesJ. Exp. Bot.57547-5572006Nicotiana tabacum PubMed
675663Wang, Z.Q.; Yuan, Y.Z.; Ou, J.Q.; Lin, Q.H.; Zhang, C.F.Glutamine synthetase and glutamate dehydrogenase contribute differentially to proline accumulation in leaves of wheat (Triticum aestivum) seedlings exposed to different salinityJ. Plant Physiol.164695-7012007Triticum aestivum PubMed
675664Wang, Z.Q.; Yuan, Y.Z.; Ou, J.Q.; Lin, Q.H.; Zhang, C.F.Glutamine synthetase and glutamate dehydrogenase contribute differentially to proline accumulation in leaves of wheat (Triticum aestivum) seedlings exposed to different salinityJ. Plant Physiol.164695—7012007Triticum aestivum PubMed
676596Masclaux-Daubresse, C.; Reisdorf-Cren, M.; Pageau, K.; Lelandais, M.; Grandjean, O.; Kronenberger, J.; Valadier, M.H.; Feraud, M.; Jouglet, T.; Suzuki, A.Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobaccoPlant Physiol.140444-4562006Nicotiana tabacum PubMed
676630Purnell, M.P.; Botella, J.R.Tobacco isoenzyme 1 of NAD(H)-dependent glutamate dehydrogenase catabolizes glutamate in vivoPlant Physiol.143530-5392007Nicotiana tabacum PubMed
676690Purnell, M.P.; Skopelitis, D.S.; Roubelakis-Angelakis, K.A.; Botella, J.R.Modulation of higher-plant NAD(H)-dependent glutamate dehydrogenase activity in transgenic tobacco via alteration of beta subunit levelsPlanta222167-1802005Nicotiana tabacum PubMed
685127Li, M.; Allen, A.; Smith, T.J.High throughput screening reveals several new classes of glutamate dehydrogenase inhibitorsBiochemistry4615089-151022007Bos taurus PubMed
686665Hamza, M.A.; Martin, S.R.; Engel, P.C.The contribution of tryptophan residues to conformational changes in clostridial glutamate dehydrogenase - W64 and W449 as mediators of the cooperative response to glutamateFEBS J.2744126-41342007Clostridium symbiosum PubMed
686673Carrigan, J.B.; Engel, P.C.Probing the determinants of coenzyme specificity in Peptostreptococcus asaccharolyticus glutamate dehydrogenase by site-directed mutagenesisFEBS J.2745167-51742007Peptoniphilus asaccharolyticus PubMed
686726Choudhury, R.; Punekar, N.S.Competitive inhibition of glutamate dehydrogenase reactionFEBS Lett.5812733-27362007Aspergillus niger PubMed
688076Forde, B.G.; Lea, P.J.Glutamate in plants: metabolism, regulation, and signallingJ. Exp. Bot.582339-23582007Arabidopsis thaliana, Nicotiana plumbaginifolia, Nicotiana tabacum PubMed
688188Yang, X.; Zhang, Q.; Li, L.; Shen, R.Structural features of aluminium(III) complexes with bioligands in glutamate dehydrogenase reaction system - a reviewJ. Inorg. Biochem.1011242-12502007Homo sapiens PubMed
688640Lehmann, T.; Ratajczak, L.The pivotal role of glutamate dehydrogenase (GDH) in the mobilization of N and C from storage material to asparagine in germinating seeds of yellow lupineJ. Plant Physiol.165149-1582008Lupinus luteus PubMed
689048Commichau, F.M.; Herzberg, C.; Tripal, P.; Valerius, O.; Stuelke, J.A regulatory protein-protein interaction governs glutamate biosynthesis in Bacillus subtilis: the glutamate dehydrogenase RocG moonlights in controlling the transcription factor GltCMol. Microbiol.65642-6542007Bacillus subtilis PubMed
689656Watanabe, M.; Itho, Y.; Jo, Y.; Yasuda, K.; Kamachi, K.; Watanabe, Y.Redox and translational regulation of glutamate dehydrogenase alpha subunits in Brassica napus under wounding stressPlant Sci.1721182-11922007Brassica napus-
689705Rosso, L.; Marques, A.C.; Reichert, A.S.; Kaessmann, H.Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selectionPLoS Genet.4e10001502008Chlorocebus sabaeus, Gorilla gorilla, Homo sapiens, Pan troglodytes, Pongo pygmaeus, Symphalangus syndactylus PubMed
692832Kawakami, R.; Sakuraba, H.; Ohshima, T.Gene cloning and characterization of the very large NAD-dependent L-glutamate dehydrogenase from the psychrophile Janthinobacterium lividum, isolated from cold soilJ. Bacteriol.1895626-56332007Janthinobacterium lividum PubMed
694766Purnell, M.P.; Skopelitis, D.S.; Roubelakis-Angelakis, K.A.; Botella, J.R.Modulation of higher-plant NAD(H)-dependent glutamate dehydrogenase activity in transgenic tobacco via alteration of beta subunit levelsPlanta22513252007Nicotiana tabacum, Solanum lycopersicum-
695431Kravos, M.; Malesic, I.Glutamate dehydrogenase as a marker of alcohol dependenceAlcohol Alcohol.4539-442010Homo sapiens PubMed
696792Joshi, C.V.; Ghormade, V.; Kunde, P.; Kulkarni, P.; Mamgain, H.; Bhat, S.; Paknikar, K.M.; Deshpande, M.V.Flocculation of dimorphic yeast Benjaminiella poitrasii is altered by modulation of NAD-glutamate dehydrogenaseBiores. Technol.1011393-13952009Benjaminiella poitrasii PubMed
697113Yang, C.; Sudderth, J.; Dang, T.; Bachoo, R.G.; McDonald, J.G.; DeBerardinis, R.J.Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signalingCancer Res.697986-79932009Homo sapiens PubMed
697654Choudhury, R.; Noor, S.; Varadarajalu, L.; Punekar, N.Delineation of an in vivo inhibitor for Aspergillus glutamate dehydrogenaseEnzyme Microb. Technol.42151-1592008Aspergillus niger PubMed
697661Bolivar, J.; Mateo, C.; Rocha-Martin, J.; Cava, F.; Berenguer, J.; Fernandez-Lafuente, R.; Guisan, J.The adsorption of multimeric enzymes on very lowly activated supports involves more enzyme subunits: Stabilization of a glutamate dehydrogenase from Thermus thermophilus by immobilization on heterofunctional supportsEnzyme Microb. Technol.44139-1442009Thermus thermophilus-
697928Hamza, M.A.; Engel, P.C.Homotropic allosteric control in clostridial glutamate dehydrogenase: different mechanisms for glutamate and NAD+?FEBS Lett.5821816-18202008Clostridium symbiosum PubMed
698313Zhang, Y.; Lu, N.; Gao, Z.Hemin-H2O2-NO2(-) induced protein oxidation and tyrosine nitration are different from those of SIN-1: a study on glutamate dehydrogenase nitrative/oxidative modificationInt. J. Biochem. Cell Biol.41907-9152009Bos taurus PubMed
698620Mailloux, R.J.; Singh, R.; Brewer, G.; Auger, C.; Lemire, J.; Appanna, V.D.alpha-Ketoglutarate dehydrogenase and glutamate dehydrogenase work in tandem to modulate the antioxidant alpha-ketoglutarate during oxidative stress in Pseudomonas fluorescensJ. Bacteriol.1913804-38102009Pseudomonas fluorescens PubMed
698927Li, M.; Smith, C.J.; Walker, M.T.; Smith, T.J.Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamicsJ. Biol. Chem.28422988-230002009Bos taurus, Escherichia coli, Tetrahymena PubMed
698996Carobbio, S.; Frigerio, F.; Rubi, B.; Vetterli, L.; Bloksgaard, M.; Gjinovci, A.; Pournourmohammadi, S.; Herrera, P.L.; Reith, W.; Mandrup, S.; Maechler, P.Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasisJ. Biol. Chem.284921-9292009Mus musculus PubMed
699188Kutz, R.; Okwumabua, O.Differentiation of highly virulent strains of Streptococcus suis serotype 2 according to glutamate dehydrogenase electrophoretic and sequence typeJ. Clin. Microbiol.463201-32072008Streptococcus suis PubMed
700651Lehmann, T.; Skrok, A.; Dabert, M.Stress-induced changes in glutamate dehydrogenase activity imply its role in adaptation to C and N metabolism in lupine embryosPhysiol. Plant.13835-472010Lupinus luteus PubMed
700719Labboun, S.; Terce-Laforgue, T.; Roscher, A.; Bedu, M.; Restivo, F.M.; Velanis, C.N.; Skopelitis, D.S.; Moshou, P.N.; Roubelakis-Angelakis, K.A.; Suzuki, A.; Hirel, B.Resolving the role of plant glutamate dehydrogenase. I. In vivo real time nuclear magnetic resonance spectroscopy experimentsPlant Cell Physiol.501761-17732009Nicotiana tabacum PubMed
700724Qiu, X.; Xie, W.; Lian, X.; Zhang, Q.Molecular analyses of the rice glutamate dehydrogenase gene family and their response to nitrogen and phosphorous deprivationPlant Cell Rep.281115-11262009Oryza sativa PubMed
701137Sharkey, M.A.; Engel, P.C.Modular coenzyme specificity: a domain-swopped chimera of glutamate dehydrogenaseProteins77268-2782009Clostridium symbiosum PubMed
701268Fontaine, J.X.; Ravel, C.; Pageau, K.; Heumez, E.; Dubois, F.; Hirel, B.; Le Gouis, J.A quantitative genetic study for elucidating the contribution of glutamine synthetase, glutamate dehydrogenase and other nitrogen-related physiological traits to the agronomic performance of common wheatTheor. Appl. Genet.119645-6622009Triticum aestivum PubMed
710758Oliveira, T.F.; Carrigan, J.B.; Hamza, M.A.; Sharkey, M.A.; Engel, P.C.; Khan, A.R.Crystallization and preliminary structural analyses of glutamate dehydrogenase from Peptoniphilus asaccharolyticusActa Crystallogr. Sect. F66523-5262010Peptoniphilus asaccharolyticus PubMed
711526Kawakami, R.; Oyama, M.; Sakuraba, H.; Ohshima, T.The unique kinetic behavior of the very large NAD-dependent glutamate dehydrogenase from Janthinobacterium lividumBiosci. Biotechnol. Biochem.74884-8872010Janthinobacterium lividum PubMed
711601Harper, C.J.; Hayward, D.; Kidd, M.; Wiid, I.; van Helden, P.Glutamate dehydrogenase and glutamine synthetase are regulated in response to nitrogen availability in Myocbacterium smegmatisBMC Microbiol.101382010Mycobacterium smegmatis PubMed
711875Griffin, J.; Engel, P.C.The -SH protection method for determining accurate K(d) values for enzyme-coenzyme complexes of NAD-dependent glutamate dehydrogenase and engineered mutants: evidence for nonproductive NADPH complexesEnzyme Res.20109514722010Clostridium symbiosum PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 1.4.1.2)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)