Information on EC 1.3.1.48 - 15-oxoprostaglandin 13-oxidase:
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EC NUMBERCOMMENTARY
1.3.1.48-

RECOMMENDED NAMEGeneOntology No.
15-oxoprostaglandin 13-oxidaseGO:0047522

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+
show the reaction diagram		----

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
oxidation----
redox reaction----
redox reactionunidentified adenovirus--699958
reduction----

PATHWAYKEGG LinkMetaCyc Link
No entries in this field

SYSTEMATIC NAMEIUBMB Comments
11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductaseReduces 15-oxoprostaglandins to 13,14-dihydro derivatives. The enzyme from placenta is specific for NAD+.

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
15-ketoprostaglandin DELTA-13-reductase----
15-ketoprostaglandin DELTA13-reductase----
15-ketoprostaglandinDELTA13-reductaseRattus norvegicus--690204
15-oxoprostaglandin 13-reductase----
15-oxoprostaglandin DELTA13-reductase----
15-oxoprostaglandin-DELTA13-reductaseMus musculusQ8VDQ1-687562
Ad-PGRunidentified adenovirus--699958
bifunctional leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductaseCavia porcellus--656219
bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductaseRattus norvegicus-a beta-NADPH-dependent alkenal/one oxidoreductase which has a role for leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandinDELTA13-reductase690204
DELTA13-15-ketoprostaglandin reductase----
leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductaseSus scrofa--390828
leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductaseCavia porcellus--390829
leukotriene B4-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductaseunidentified adenovirus--699958
LTB4 12-HD/PGRCavia porcellus--656219
LTBDH/PGRunidentified adenovirus--699958
NAD(P)H-dependent alkenal/one oxidoreductaseRattus norvegicus--390830
PGRRattus norvegicus--690204
PGRunidentified adenovirus--699958
PGR-2Mus musculusQ8VDQ1-687562
prostaglandin 13-reductase----
prostaglandin DELTA13-reductase----
reductase, 15-oxo-DELTA13-prostaglandin----

CAS REGISTRY NUMBERCOMMENTARY
57406-74-3-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Bos taurus-390820, 390823, 390825, 390827--Manually annotated by BRENDA team
Cavia porcellus-390829, 656219, 674369--Manually annotated by BRENDA team
Gallus gallus-390820--Manually annotated by BRENDA team
Homo sapiens-390820, 390821, 390822, 390824--Manually annotated by BRENDA team
Mus musculus-687562Q8VDQ1UniprotManually annotated by BRENDA team
Rattus norvegicus-390826, 390830, 690204--Manually annotated by BRENDA team
Sus scrofa-390827, 390828--Manually annotated by BRENDA team
unidentified adenovirus-699958--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
(5S,12R)-dihydroxy-(6E,8Z,10Z,14E)-eicosatetraenoic acid + NADH?
show the reaction diagram		Cavia porcellus-15-keto-prostaglandin-13-reductase activity is 200fold higher than leukotrien B4-12hydroxydehydrogenase activity390829--?
(5S,12R)-dihydroxy-(6E,8Z,10Z,14E)-eicosatetraenoic acid + NADH?
show the reaction diagram		Sus scrofa-trivial name leukotriene B4, enzyme exhibits a 15-ketoprostaglandin-13-reductase and a very low leukotriene B4 12-hydroxydehydrogenase activity390827--?
(5S,6R)-dihydroxy-15-oxo-(7E,9E,11Z,13E)-eicosatetraenoic acid + NADH13,14-dihydro-(5S,6R)-dihydroxy-15-oxo-(7E,9E,11Z)-eicosatetraenoic acid + NAD+
show the reaction diagram		Sus scrofa-trivial name 15-oxo-lipoxin A4390828-390828?
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H(5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+
show the reaction diagram		Gallus gallus, Homo sapiens--390820-390820ir
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H(5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+
show the reaction diagram		Rattus norvegicus--390830-390830-
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H(5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H(5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+
show the reaction diagram		Sus scrofa--390827-390827ir
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H(5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+
show the reaction diagram		Bos taurus--390820-390820ir
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H(5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+
show the reaction diagram		Bos taurus--390827-390827ir
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H(5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+
show the reaction diagram		Homo sapiens-no substrates: 15-hydroxyprostaglandins, progesterone, cortisone, orotic acid, fumaric acid390822-390822-
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H(5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+
show the reaction diagram		Homo sapiens-no substrates: 15-hydroxyprostaglandins, progesterone, cortisone, orotic acid, fumaric acid390821-390821ir
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H(5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+
show the reaction diagram		Homo sapiens-55% of activity with 15-keto-prostaglandin E2390824-390824ir
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H(5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+
show the reaction diagram		Bos taurus-no substrate: prostaglandin E1390823-390823ir
(Z)-3-[(5-methoxy-3-oxo-2(3H)-benzofuranylidene)-methyl]benzoic acid + NAD(P)H[(5-methoxy-3-oxo-benzofurane)-methyl]benzoic acid + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
1-(p-carboxyphenyl)-5-cyano-3-oxo-1-pentene + NAD(P)H1-(p-carboxyphenyl)-5-cyano-3-oxo-pentane + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+
show the reaction diagram		Cavia porcellus--390829--?
11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+
show the reaction diagram		Sus scrofa--390827--?
11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+
show the reaction diagram		Bos taurus--390825-390825?
11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+
show the reaction diagram		Bos taurus--390827-390827?
11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+
show the reaction diagram		Homo sapiens-i.e. 15-ketoprostaglandin E2390820-390820?
11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+
show the reaction diagram		Homo sapiens-i.e. 15-ketoprostaglandin E2390821-390821?
11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+
show the reaction diagram		Homo sapiens-i.e. 15-ketoprostaglandin E2390822-390822?
11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+
show the reaction diagram		Homo sapiens-i.e. 15-ketoprostaglandin E2390824-390824?
11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+
show the reaction diagram		Bos taurus-i.e. 15-ketoprostaglandin E2390820-390820?
11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NADPH11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NADP+
show the reaction diagram		Rattus norvegicus--690204--?
15-ketoprostaglandin A1 + NAD(P)H?
show the reaction diagram		Homo sapiens--390821--?
15-ketoprostaglandin A1 + NAD(P)H?
show the reaction diagram		Homo sapiens-108% of activity with 15-keto-prostaglandin E2390824--?
15-ketoprostaglandin B1 + NAD(P)H?
show the reaction diagram		Homo sapiens--390821--?
15-ketoprostaglandin B1 + NAD(P)H?
show the reaction diagram		Homo sapiens-79% of activity with 15-keto-prostaglandin E2390824--?
15-ketoprostaglandin E + NAD(P)H?
show the reaction diagram		Bos taurus--390823---
15-ketoprostaglandin E + NAD(P)H?
show the reaction diagram		Gallus gallus, Homo sapiens, Bos taurus-second step in metabolism of E- and Falpha-type prostaglandins390820--?
15-ketoprostaglandin E1 + NADPH?
show the reaction diagram		Mus musculusQ8VDQ1-687562--?
15-ketoprostaglandin E1 + NADPH?
show the reaction diagram		Homo sapiens--390820, 390821, 390824---
15-ketoprostaglandin E1 + NADPH?
show the reaction diagram		Sus scrofa--390827---
15-ketoprostaglandin E1 + NADPH?
show the reaction diagram		Bos taurus--390820---
15-ketoprostaglandin E2 + NADPH13,14-dihydro-15-keto-prostaglandin E2 + NADP+
show the reaction diagram		Mus musculusQ8VDQ1-687562--?
15-ketoprostaglandin E2 + NADPH?
show the reaction diagram		Rattus norvegicus--690204--?
15-ketoprostaglandin F1alpha + NAD(P)H?
show the reaction diagram		Rattus norvegicus--390826--?
15-ketoprostaglandin F1alpha + NAD(P)H?
show the reaction diagram		Bos taurus--390820--?
15-ketoprostaglandin F1alpha + NADPH?
show the reaction diagram		Mus musculusQ8VDQ1-687562--?
15-ketoprostaglandin F2alpha + NADPH?
show the reaction diagram		Mus musculusQ8VDQ1-687562--?
15-ketoprostaglandin F2alpha + NADPH?
show the reaction diagram		Homo sapiens--390821, 390824---
15-ketoprostaglandin F2alpha + NADPH?
show the reaction diagram		Rattus norvegicus--390826---
15-oxoprostaglandin F1alpha + NAD(P)H?
show the reaction diagram		Gallus gallus, Homo sapiens, Bos taurus-second step in metabolism of E- and Falpha-type prostaglandins390820--?
3-nonen-2-one + NADPHnonane-2-one + NADP+
show the reaction diagram		Rattus norvegicus--390830-390830?
3-penten-2-one + NADPHpentane-2-one + NADP+
show the reaction diagram		Rattus norvegicus--390830-390830?
4-hydroxy-2-hexenal + NADPH4-hydroxyhexanal + NADP+
show the reaction diagram		Rattus norvegicus--390830-390830?
4-hydroxy-2-nonenal + NADPH4-hydroxynonanal + NADP+
show the reaction diagram		Rattus norvegicus--390830-390830?
4-hydroxy-2-nonenal + NADPH?
show the reaction diagram		Rattus norvegicus--690204--?
6,15-diketo-prostaglandin F1alpha + NAD(P)H?
show the reaction diagram		Bos taurus--390820--?
9,11-dihydroxy-15-oxoprosta-5,13-dien-1-oic acid + NAD(P)H9,11-dihydroxy-15-oxoprosta-5-en-1-oic aicd + NAD(P)+
show the reaction diagram		Homo sapiens-56% of activity with 15-keto-prostaglandin E2390824-390824-
9,11-dihydroxy-15-oxoprosta-5,13-dien-1-oic acid + NAD(P)H9,11-dihydroxy-15-oxoprosta-5-en-1-oic aicd + NAD(P)+
show the reaction diagram		Homo sapiens-i.e. 15-ketoprostaglandin F2alpha390821-390821-
9,11-dihydroxy-15-oxoprosta-5,13-dien-1-oic acid + NAD(P)H9,11-dihydroxy-15-oxoprosta-5-en-1-oic aicd + NAD(P)+
show the reaction diagram		Homo sapiens-i.e. 15-ketoprostaglandin F2alpha390822-390822-
9,11-dihydroxy-15-oxoprosta-5,13-dien-1-oic acid + NAD(P)H9,11-dihydroxy-15-oxoprosta-5-en-1-oic aicd + NAD(P)+
show the reaction diagram		Homo sapiens-i.e. 15-ketoprostaglandin F2alpha390824-390824-
acrolein + NADPHpropanal + NADP+
show the reaction diagram		Rattus norvegicus--390830-390830?
alpha-methylcinnamaldehyde + NADPH?
show the reaction diagram		Rattus norvegicus--390830--?
benzylidene acetone + NADPH?
show the reaction diagram		Rattus norvegicus--690204--?
benzylidene acetonphenone + NADPH?
show the reaction diagram		Rattus norvegicus--690204--?
beta-ionone + NAD(P)H?
show the reaction diagram		Rattus norvegicus--390826--?
chalcone + NADPH?
show the reaction diagram		Rattus norvegicus--390830--?
cinnamaldehyde + NADPH?
show the reaction diagram		Rattus norvegicus--690204--?
cinnamoylthiophene + NADPH?
show the reaction diagram		Rattus norvegicus--690204--?
curcumin + NAD(P)H?
show the reaction diagram		Rattus norvegicus--390826--?
ethylvinylketone + NADPHpentane-3-one + NADP+
show the reaction diagram		Rattus norvegicus--390830-390830?
leukotriene B4 + NADPH?
show the reaction diagram		Rattus norvegicus--690204--?
leukotriene B4 + NADPH?
show the reaction diagram		Sus scrofa--390827---
phenyl propenyl ketone + NADPH?
show the reaction diagram		Rattus norvegicus--690204--?
trans-2-(o-hydroxybenzylidene)acetophenone + NAD(P)H(o-hydroxybenzyl)acetophenone + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
trans-2-benzylidenecyclohexan-2-one + NAD(P)Hbenzylcyclohexan-2-one + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
trans-2-butenal + NAD(P)Hbutanal + NAD(P)+
show the reaction diagram		Rattus norvegicus--390830-390830-
trans-2-butenal + NAD(P)Hbutanal + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
trans-2-decenal + NADPHdecanal + NADP+
show the reaction diagram		Rattus norvegicus--390830-390830?
trans-2-dodecenal + NADPHdodecanal + NADP+
show the reaction diagram		Rattus norvegicus--390830-390830?
trans-2-hexenal + NAD(P)Hhexanal + NAD(P)+
show the reaction diagram		Rattus norvegicus--390830-390830-
trans-2-hexenal + NAD(P)Hhexanal + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
trans-2-hexenal + NADPH?
show the reaction diagram		Rattus norvegicus--690204--?
trans-2-nonenal + NADPHnonanal + NADP+
show the reaction diagram		Rattus norvegicus--390830-390830?
trans-2-octenal + NADPHoctanal + NADP+
show the reaction diagram		Rattus norvegicus--390830-390830?
trans-2-pentenal + NADPHpentanal + NADP+
show the reaction diagram		Rattus norvegicus--390830-390830?
trans-3-(2-furyl)acrolein + NAD(P)H2-furylpropanal + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
trans-4-furyl-3-buten-2-one + NAD(P)H4-furyl-butane-2-one + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
trans-benzylideneacetone + NAD(P)Hbenzylacetone + NAD(P)+
show the reaction diagram		Rattus norvegicus--390830-390830-
trans-benzylideneacetone + NAD(P)Hbenzylacetone + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
trans-benzylideneacetophenone + NAD(P)Hbenzylacetophenone + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
trans-cinnamaldehyde + NAD(P)H?
show the reaction diagram		Rattus norvegicus--390830---
trans-cinnamaldehyde + NAD(P)H?
show the reaction diagram		Rattus norvegicus--390826--?
trans-cinnamic acid ethyl ester + NAD(P)H?
show the reaction diagram		Rattus norvegicus--390826--?
trans-cinnamoyl thiophene + NAD(P)H?
show the reaction diagram		Rattus norvegicus--390826--?
trans-methylvinylketone + NAD(P)Hbutane-2-one + NAD(P)+
show the reaction diagram		Rattus norvegicus--390830-390830-
trans-methylvinylketone + NAD(P)Hbutane-2-one + NAD(P)+
show the reaction diagram		Rattus norvegicus--390826-390826?
trans-phenyl-1-propenyl ketone + NAD(P)Hphenylpropane-1-one + NAD+
show the reaction diagram		Rattus norvegicus--390826-390826?
trans-trans-2,4-hexadienal + NAD(P)H?
show the reaction diagram		Rattus norvegicus--390830---
trans-trans-2,4-hexadienal + NAD(P)H?
show the reaction diagram		Rattus norvegicus--390826--?
methyl vinyl ketone + NADPH?
show the reaction diagram		Rattus norvegicus--690204--?
additional information?-Cavia porcellus-essential enzyme for eicosanoid inactivation656219---
additional information?-Mus musculusQ8VDQ1not active towards 6-keto-prostaglandin F1alpha, prostaglandin F2beta, 11beta-prostaglandin F2alpha, 13,14-dihydro-15-keto-prostaglandin D2, 13,14-dihydro-15-keto-prostaglandin E2, 13,14-dihydro-15-keto-PGF2alpha, and leukotriene B4687562---
additional information?-unidentified adenovirus-bifunctional enzyme capable of inactivating leukotriene B4 and 15-oxo-prostaglandins, enzyme plays a role in growth suppressive functions in lung cancer699958---

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
15-ketoprostaglandin E + NAD(P)H?
show the reaction diagram		Gallus gallus, Homo sapiens, Bos taurus-second step in metabolism of E- and Falpha-type prostaglandins390820--
15-oxoprostaglandin F1alpha + NAD(P)H?
show the reaction diagram		Gallus gallus, Homo sapiens, Bos taurus-second step in metabolism of E- and Falpha-type prostaglandins390820--
additional information?-Cavia porcellus-essential enzyme for eicosanoid inactivation656219--
additional information?-unidentified adenovirus-bifunctional enzyme capable of inactivating leukotriene B4 and 15-oxo-prostaglandins, enzyme plays a role in growth suppressive functions in lung cancer699958--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
NAD(P)HHomo sapiens--390820, 390821, 390822, 390824 2D-image
NAD(P)HBos taurus-bovine lung: enzyme can use both NADPH and NADH390820, 390823 2D-image
NAD(P)HBos taurus-enzyme from iris-ciliary body prefers NADPH390825 2D-image
NAD(P)HRattus norvegicus-in crude extracts: NADH is 30% as effective as NADPH, in purified enzyme: NADH is 10% as effectic as NADPH390826 2D-image
NAD(P)HBos taurus--390827 2D-image
NAD(P)HSus scrofa-3fold higher activity with NADPH compared to NADH390827 2D-image
NAD(P)Hunidentified adenovirus--699958 2D-image
NADHHomo sapiens-human placenta: enzyme can use only NADH390820, 390821, 390822, 390824 2D-image
NADHSus scrofa-reduction of 15-oxo-lipoxin A4 to 13,14-dihydro lipoxin A4 depends on NADH390828 2D-image
NADPHMus musculusQ8VDQ1-687562 2D-image
NADPHRattus norvegicus--690204 2D-image
nicotinamide hypoxanthine dinucleotideHomo sapiens--390821 2D-image

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
No entries in this field

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
13,14-Dihydro-15-prostaglandin E2Homo sapiens-competitive product inhibition390824 2D-image
15-keto prostaglandin F2alphaRattus norvegicus-43.06% residual activity at 0.1 mM690204 2D-image
benzylidene acetophenoneRattus norvegicus-21.09% residual activity at 0.5 mM690204 2D-image
Cibacron blue 3 G-AHomo sapiens-competitive inhibition vs. NADH, noncompetitive vs. 15-keto-prostaglandin E2390821 2D-image
Cibacron blue 3 G-AHomo sapiens--390824 2D-image
DicoumarolBos taurus-0.1 mM, 86% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2390825 2D-image
DicoumarolRattus norvegicus-0.1 mM, complete inhibition390826 2D-image
DicoumarolRattus norvegicus-11.45% residual activity at 0.1 mM690204 2D-image
DisulfiramBos taurus-0.1 mM, 61% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2390825 2D-image
IndomethacinBos taurus-0.1 mM, 97% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2390825 2D-image
IndomethacinRattus norvegicus-0.1 mM, 95% inhibition390826 2D-image
IndomethacinCavia porcellus--674369 2D-image
NADHHomo sapiens-uncompetitive inhibition at high concentrations390824 2D-image
NADP+Bos taurus--390820, 390823 2D-image
NADPHHomo sapiens-competitive inhibition vs. NADH, noncompetitive vs. 15-keto-prostaglandin E2390821 2D-image
NADPHHomo sapiens--390824 2D-image
p-chloromercuribenzoateBos taurus, Homo sapiens--390820 2D-image
p-chloromercuribenzoateHomo sapiens-0.0001 mM, 85% inhibition390821, 390824 2D-image
p-chloromercuribenzoateBos taurus-0.1 mM, complete inhibition390823 2D-image
p-chloromercuribenzoateRattus norvegicus-0.1 mM, 97% inhibition390826 2D-image
quercitrinBos taurus-0.1 mM, 76% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2390825 2D-image
quercitrinRattus norvegicus-95% inhibition390826 2D-image
quercitrinRattus norvegicus-13.14% residual activity at 0.1 mM690204 2D-image
IndomethacinRattus norvegicus-14.22% residual activity at 0.1 mM690204 2D-image
additional informationRattus norvegicus-finasteride has no inhibitory effect690204-

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.093-(5S,12R)-dihydroxy-(6E,8Z,10Z,14E)-eicosatetraenoic acidCavia porcellus--390829 2D-image
0.0085-15-Keto-prostaglandin E2Cavia porcellus--390829 2D-image
0.0075-15-Ketoprostaglandin A1Homo sapiens--390821, 390824 2D-image
0.0112-15-Ketoprostaglandin B1Homo sapiens--390821, 390824 2D-image
0.0039-15-ketoprostaglandin E1Homo sapiens--390821, 390824 2D-image
0.0077-15-ketoprostaglandin E1Sus scrofa--390827 2D-image
0.0083-15-ketoprostaglandin E1Sus scrofa-recombinant enzyme390827 2D-image
0.01-15-ketoprostaglandin E1Homo sapiens-human placenta390820 2D-image
0.03-15-ketoprostaglandin E1Bos taurus-bovine lung390820 2D-image
0.0344-15-ketoprostaglandin E1Mus musculusQ8VDQ1in 0.1 M Tris-HCl (pH 7.4), at 37°C687562 2D-image
0.0078-15-Ketoprostaglandin E2Rattus norvegicus-in 100 mM phosphate buffer (pH 7.4), at 25°C690204 2D-image
0.0127-15-Ketoprostaglandin E2Homo sapiens--390821, 390824 2D-image
0.0182-15-Ketoprostaglandin E2Sus scrofa-recombinant enzyme390827 2D-image
0.019-15-Ketoprostaglandin E2Sus scrofa--390827 2D-image
0.0496-15-Ketoprostaglandin E2Mus musculusQ8VDQ1in 0.1 M Tris-HCl (pH 7.4), at 37°C687562 2D-image
0.062-15-Ketoprostaglandin E2Bos taurus--390820 2D-image
0.07-15-Ketoprostaglandin E2Homo sapiens--390822 2D-image
0.0592-15-ketoprostaglandin F1alphaMus musculusQ8VDQ1in 0.1 M Tris-HCl (pH 7.4), at 37°C687562 2D-image
0.184-15-ketoprostaglandin F1alphaBos taurus--390820 2D-image
0.000213-15-Ketoprostaglandin F2alphaRattus norvegicus--390826 2D-image
0.0108-15-Ketoprostaglandin F2alphaHomo sapiens--390821, 390824 2D-image
0.1088-15-Ketoprostaglandin F2alphaMus musculusQ8VDQ1in 0.1 M Tris-HCl (pH 7.4), at 37°C687562 2D-image
0.001-15-oxoprostaglandin E1Rattus norvegicus--390830 2D-image
0.016-3-nonen-2-oneRattus norvegicus--390830 2D-image
0.49-3-penten-2-oneRattus norvegicus--390830 2D-image
0.21-4-hydroxy-2-hexenalRattus norvegicus--390830 2D-image
0.12-4-hydroxy-2-nonenalRattus norvegicus--390830 2D-image
0.461-4-hydroxy-2-nonenalRattus norvegicus-in 100 mM phosphate buffer (pH 7.4), at 25°C690204 2D-image
0.258-6,15-diketo-prostaglandin F1alphaBos taurus--390820 2D-image
0.15-acroleinRattus norvegicus--390830 2D-image
1.7-alpha-methylcinnamaldehydeRattus norvegicus--390830 2D-image
0.0277-benzylidene acetoneRattus norvegicus-in 100 mM phosphate buffer (pH 7.4), at 25°C690204 2D-image
0.039-benzylidene acetoneRattus norvegicus--390830 2D-image
0.1399-benzylidene acetonphenoneRattus norvegicus-in 100 mM phosphate buffer (pH 7.4), at 25°C690204 2D-image
0.18-chalconeRattus norvegicus--390830 2D-image
0.075-cinnamaldehydeRattus norvegicus--390830 2D-image
1.426-cinnamaldehydeRattus norvegicus-in 100 mM phosphate buffer (pH 7.4), at 25°C690204 2D-image
0.0791-cinnamoylthiopheneRattus norvegicus-in 100 mM phosphate buffer (pH 7.4), at 25°C690204 2D-image
3.9-CrotonaldehydeRattus norvegicus--390830 2D-image
0.11-ethylvinylketoneRattus norvegicus--390830 2D-image
0.063-hypoxanthine dinucleotideHomo sapiens--390821, 390824-
0.01-leukotriene B4Sus scrofa-recombinant enzyme390827 2D-image
0.1289-Methyl vinyl ketoneRattus norvegicus-in 100 mM phosphate buffer (pH 7.4), at 25°C690204 2D-image
0.58-methylvinylketoneRattus norvegicus--390830 2D-image
0.032-NADHHomo sapiens--390821, 390824 2D-image
0.0548-NADHHomo sapiens--390822 2D-image
0.0880.094NADHBos taurus--390823, 390827 2D-image
0.091-NADHBos taurus--390820 2D-image
0.153-NADHSus scrofa--390827 2D-image
0.16-NADHSus scrofa-recombinant enzyme390827 2D-image
0.0050.009NADPHBos taurus--390823 2D-image
0.008-NADPHBos taurus--390820 2D-image
0.015-NADPHSus scrofa--390827 2D-image
0.016-NADPHSus scrofa-recombinant enzyme390827 2D-image
0.0946-NADPHMus musculusQ8VDQ1in 0.1 M Tris-HCl (pH 7.4), at 37°C687562 2D-image
0.0123-phenyl propenyl ketoneRattus norvegicus-in 100 mM phosphate buffer (pH 7.4), at 25°C690204 2D-image
0.41-trans,trans-2,4-nonadienalRattus norvegicus--390830 2D-image
0.04-trans-2-decenalRattus norvegicus--390830 2D-image
0.06-trans-2-dodecenalRattus norvegicus--390830 2D-image
1-trans-2-hexenalRattus norvegicus--390830 2D-image
2.194-trans-2-hexenalRattus norvegicus-in 100 mM phosphate buffer (pH 7.4), at 25°C690204 2D-image
0.046-trans-2-nonenalRattus norvegicus--390830 2D-image
0.36-trans-2-octenalRattus norvegicus--390830 2D-image
2.4-trans-2-pentenalRattus norvegicus--390830 2D-image

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.7115-ketoprostaglandin EBos taurus--390823 2D-image
0.12-15-ketoprostaglandin E1Mus musculusQ8VDQ1in 0.1 M Tris-HCl (pH 7.4), at 37°C687562 2D-image
0.517-15-ketoprostaglandin E1Sus scrofa-cofactor NADH390827 2D-image
1.52-15-ketoprostaglandin E1Sus scrofa-cofactor NADPH390827 2D-image
0.19-15-Ketoprostaglandin E2Mus musculusQ8VDQ1in 0.1 M Tris-HCl (pH 7.4), at 37°C687562 2D-image
0.22-15-ketoprostaglandin F1alphaMus musculusQ8VDQ1in 0.1 M Tris-HCl (pH 7.4), at 37°C687562 2D-image
0.25-15-Ketoprostaglandin F2alphaMus musculusQ8VDQ1in 0.1 M Tris-HCl (pH 7.4), at 37°C687562 2D-image
40-15-oxoprostaglandin E1Rattus norvegicus--390830 2D-image
19.8-3-nonen-2-oneRattus norvegicus--390830 2D-image
18.5-3-penten-2-oneRattus norvegicus--390830 2D-image
13.4-4-hydroxy-2-hexenalRattus norvegicus--390830 2D-image
67.3-4-hydroxy-2-nonenalRattus norvegicus--390830 2D-image
3.72-acroleinRattus norvegicus--390830 2D-image
13.1-alpha-methylcinnamaldehydeRattus norvegicus--390830 2D-image
54.7-benzylidene acetoneRattus norvegicus--390830 2D-image
32.3-chalconeRattus norvegicus--390830 2D-image
15.7-cinnamaldehydeRattus norvegicus--390830 2D-image
8.05-CrotonaldehydeRattus norvegicus--390830 2D-image
160-ethylvinylketoneRattus norvegicus--390830 2D-image
156-methylvinylketoneRattus norvegicus--390830 2D-image
0.16-NADPHMus musculusQ8VDQ1in 0.1 M Tris-HCl (pH 7.4), at 37°C687562 2D-image
17.2-trans,trans-2,4-nonadienalRattus norvegicus--390830 2D-image
70.8-trans-2-decenalRattus norvegicus--390830 2D-image
60.2-trans-2-dodecenalRattus norvegicus--390830 2D-image
28.8-trans-2-hexenalRattus norvegicus--390830 2D-image
94.5-trans-2-nonenalRattus norvegicus--390830 2D-image
89.7-trans-2-octenalRattus norvegicus--390830 2D-image
16.8-trans-2-pentenalRattus norvegicus--390830 2D-image

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.079-13,14-Dihydro-15-prostaglandin E2Homo sapiens--390824 2D-image
1.25e-05-Cibacron Blue 3G-AHomo sapiens--390821, 390824 2D-image
1e-05-NADPHHomo sapiens--390821, 390824 2D-image

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
0.00026-Bos taurus-enzyme activity in cornea, substrate 15-ketoprostaglandin, cofactor NADPH390825
0.000389-Bos taurus-enzyme activity in retina, substrate 15-ketoprostaglandin, cofactor NADPH390825
0.00085-Bos taurus-enzyme activity in retinal pigment epithelium, substrate 15-ketoprostaglandin, cofactor NADPH390825
0.000945-Bos taurus-enzyme purified from iris-ciliary cytosol390825
0.0012-Bos taurus-enzyme activity in ciliary body, substrate 15-ketoprostaglandin, cofactor NADPH390825
0.00145-Bos taurus-enzyme activity in iris, substrate 15-ketoprostaglandin, cofactor NADPH390825
0.0405-Homo sapiens--390822
0.115-Mus musculusQ8VDQ1using 15-ketoprostaglandin E1 as a substrate, at 37°C687562
0.1784-Mus musculusQ8VDQ1using 15-ketoprostaglandin E2 as a substrate, at 37°C687562
0.2064-Mus musculusQ8VDQ1using 15-ketoprostaglandin F1alpha as a substrate, at 37°C687562
0.2309-Mus musculusQ8VDQ1using 15-ketoprostaglandin F2alpha as a substrate, at 37°C687562
0.393-Homo sapiens--390824
0.425-Homo sapiens--390821
1.067-Bos taurus--390820, 390823
2.05-Rattus norvegicus--390826
2.56-Sus scrofa--390827
2.6-Sus scrofa-recombinant enzyme expressed in Escherichia coli390827
additional information-unidentified adenovirus-after restoration of LTBDH/PGR expression in LTBDH/PGR-negative (H1299) or -low (A549) lung cancer cell lines, the restored enzyme induces apoptosis and growth inhibition in vitro, restoration of LTBDH/PGR expression is effective in preventing lung cancer growth in vitro and in vivo; cell cycle alterations induced by LTBDH/PGR over-expression are assessed with Ad-GFP or Ad-PGR after infection at 100 MOI for 72 h, after infection with Ad-PGR, the apoptosis population in A549 cells and H1299 cells is 8.59% and 9.57%, whereas apoptosis population is not detected significantly in H157 infected cells; effects of induced expression of LTBDH/PGR in H1299 cells, LTBDH/PGR expression increases in a dose and time dependent manner after tetracycline treatment, marked expression is observed at day 4 and significantly affects cell proliferation beginning day 5 causing reduction in cell number and suggesting that LTBDH/PGR expression inhibit growth of H1299 cells; the expression of apoptosis-related proteins BAX, Bcl-2 and CD44 in H1299 and H157 cells is not changed by LTBDH/PGR over-expression except for BAX which is decreased in H157 cells, endogenous p53 and p21 are not expressed in both H1299 and H157 cells699958

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
5.5-Homo sapiens--390822
7.5-unidentified adenovirus-assay at699958

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
6.57.5Homo sapiens-spontaneous oxidation of NADH below pH 6.0390822
6.58Rattus norvegicus--390826

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
25-Homo sapiens-assay at390821, 390822, 390824
37-Bos taurus-assay at390820, 390823
37-unidentified adenovirus-assay at699958

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
3T3-L1 cellMus musculusQ8VDQ1-687562Manually annotated by BRENDA team
A-549 cellunidentified adenovirus-human lung adenocarcinoma cell, infected with 15-oxo-prostaglandin 13-reductase699958Manually annotated by BRENDA team
adipocyteMus musculusQ8VDQ1-687562Manually annotated by BRENDA team
adrenal glandRattus norvegicus--390826Manually annotated by BRENDA team
brainRattus norvegicus--390826Manually annotated by BRENDA team
ciliary bodyBos taurus--390825Manually annotated by BRENDA team
corneaBos taurus--390825Manually annotated by BRENDA team
heartGallus gallus--390820Manually annotated by BRENDA team
heartRattus norvegicus--390826Manually annotated by BRENDA team
irisBos taurus--390825Manually annotated by BRENDA team
kidneyRattus norvegicus--390826Manually annotated by BRENDA team
liverRattus norvegicus--390826, 690204Manually annotated by BRENDA team
liverCavia porcellus--390829Manually annotated by BRENDA team
lungBos taurus--390820, 390823, 390827Manually annotated by BRENDA team
lungRattus norvegicus--390826Manually annotated by BRENDA team
lungSus scrofa--390827, 390828Manually annotated by BRENDA team
lung cancer cell lineunidentified adenovirus--699958Manually annotated by BRENDA team
NCI-H1299 cellunidentified adenovirus-infected with 15-oxo-prostaglandin 13-reductase699958Manually annotated by BRENDA team
NCI-H157 cellunidentified adenovirus-infected with 15-oxo-prostaglandin 13-reductase699958Manually annotated by BRENDA team
pancreasRattus norvegicus--390826Manually annotated by BRENDA team
placentaHomo sapiens--390820, 390821, 390822, 390824Manually annotated by BRENDA team
retinaBos taurus-retinal pigment epithelium choroid390825Manually annotated by BRENDA team
small intestineRattus norvegicus--390826Manually annotated by BRENDA team
spleenRattus norvegicus--390826Manually annotated by BRENDA team
testisRattus norvegicus--390826Manually annotated by BRENDA team

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
cytosolBos taurus--5829390825Manually annotated by BRENDA team
cytosolRattus norvegicus--5829690204Manually annotated by BRENDA team

PDBSCOPCATHORGANISM
1v3t, downloadSCOP (1v3t)CATH (1v3t)Cavia porcellus
1v3u, downloadSCOP (1v3u)CATH (1v3u)Cavia porcellus
1v3v, downloadSCOP (1v3v)CATH (1v3v)Cavia porcellus
2dm6, downloadSCOP (2dm6)CATH (2dm6)Cavia porcellus
2vna, downloadSCOP (2vna)CATH (2vna)Homo sapiens
2w4q, downloadSCOP (2w4q)CATH (2w4q)Homo sapiens
2w98, downloadSCOP (2w98)CATH (2w98)Homo sapiens
2y05, downloadSCOP (2y05)CATH (2y05)Homo sapiens
2zb4, downloadSCOP (2zb4)CATH (2zb4)Homo sapiens
2zb7, downloadSCOP (2zb7)CATH (2zb7)Homo sapiens
2zb8, downloadSCOP (2zb8)CATH (2zb8)Homo sapiens
2zb3, downloadSCOP (2zb3)CATH (2zb3)Mus musculus

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
42000-Rattus norvegicus-gel filtration390826
55000-Bos taurus-gel filtration390825
56000-Bos taurus-gel filtration390820, 390823
68500-Homo sapiens-gel filtration390820, 390824

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
dimerHomo sapiens-2 * 35000, SDS-PAGE390824
monomerBos taurus-1 * 57000, SDS-PAGE390825
monomerRattus norvegicus-1 * 39500, SDS-PAGE390826

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
crystal structure of the bifunctional leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, the binary complex structure with NADP+, and the ternary complex structure with NADP+ and 15-oxo-prostaglandin E2, batch method using the automated crystallization system TERA by mixing equal volumes of protein solution (20 mM Tris-HCL, pH 8.0, 150 mM NaCl, 1 mM dithiothreitol) and precipitating solution (100 mM 4-morpholineethanesulfonic acid, pH 5.5-6.8), 17.5-27.5% polyethylene glycol 4000, 50 mM MgCl2 at 18°CCavia porcellus-656219
leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex in ternary complex with indomethacin and NADP+. Indomethacin binds in anti-configuration at one of the active side clefts of the homodimer interface of the enzyme. The chlorobenzene is buried in the hydrophobic pore and the carboxyl group interacts with the guanidino group of R56 and the phenolic hydroxyl group of Y262Cavia porcellus-674369

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
No entries in this field

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-4°C, 0.1 M sodium phosphate, pH 7.4, 1 mM EDTA, 1 mM mercaptoethanol, stable for more than 1 monthBos taurus-390820, 390823
-80°C, NADH-linked activity is lost overnightBos taurus-390825
-80°C, stable for more than 1 yearBos taurus-390820
0°C, NADPH-linked activity is lost after a few hoursBos taurus-390825
-20°C, 50% glycerol v/v, 5 mM potassium phosphate, 1 mM EDTA, pH 7.0, stable for at least 6 monthsHomo sapiens-390821, 390824
4°C, stable for several weeks in absence of glycerolHomo sapiens-390821

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-Bos taurus-390820, 390823, 390825
-Cavia porcellus-656219
recombinant enzymeCavia porcellus-390829
-Homo sapiens-390821, 390822, 390824
glutathione-Sepharose column chromatographyMus musculusQ8VDQ1687562
2',5'-ADP Sepharose 4B column chromatography and HisTrap HP column chromatographyRattus norvegicus-690204
DEAE-cellulose, phenyl-toyopearl, blue-toyopearl, hydroxyapatite, liver enzymeRattus norvegicus-390826
recombinant enzymeRattus norvegicus-390830
native and recombinant enzymeSus scrofa-390827

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
expression in Escherichia coli as glutathione-S-transferase fusion proteinCavia porcellus-390829
expressed in Escherichia coli strain XL1-BlueMus musculusQ8VDQ1687562
expressed in Escherichia coli Top10 cellsRattus norvegicus-690204
expression in Escherichia coliRattus norvegicus-390830
-Sus scrofa-390828
expression in Escherichia coliSus scrofa-390827
effects of LTBDH/PGR expression in LTBDH/PGR-negative and -positive lung cancer cells by infection with adenovirus carrying the LTBDH/PGR gene and by stable transfection with an inducible LTBDH/PGR expression vectorunidentified adenovirus-699958

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

DISEASETITLE OF PUBLICATIONLINK TO PUBMED
Adenoviridae InfectionsRestoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo. PubMed
Lung NeoplasmsRestoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo. PubMed

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISMLINK TO PUBMEDSOURCE
390820Hansen, H.S.Purification and assay of 15-ketoprostaglandin delta 13-reductase from bovine lungMethods Enzymol.86156-1671982Bos taurus, Gallus gallus, Homo sapiens PubMed
390821Jarabak, J.Isolation and properties of a 15-ketoprostaglandin delta 13-reductase from human placentaMethods Enzymol.86163-1671982Homo sapiens PubMed
390822Westbrook, C.; Jarabak, J.Purification and partial characterization of an NADH-linked delta13-15-ketoprostaglandin reductase from human placentaBiochem. Biophys. Res. Commun.66541-5461975Homo sapiens PubMed
390823Hansen, H.S.Purification and characterization of a 15-ketoprostaglandin delta 13-reductase from bovine lungBiochim. Biophys. Acta574136-1451979Bos taurus PubMed
390824Westbrook, C.; Jarabak, J.15-Ketoprostaglandin delta13 reductase from human placenta: purification, kinetics, and inhibitor bindingArch. Biochem. Biophys.185429-4421978Homo sapiens PubMed
390825Nikaido, H.; Moriishi, M.; Mishima, H.K.; Kitamura, S.; Tatsumi, K.15-Ketoprostaglandin delta 13-reductase activity in bovine ocular tissuesCurr. Eye Res.1217-22.1993Bos taurus PubMed
390826Kitamura, S.; Katsura, H.; Tatsumi, K.Purification of a 15-ketoprostaglandin DELTA13-reductase from rat liver and its ability to reduce the double bond of xenobioticsBiochem. Mol. Biol. Int.30839-8471993Rattus norvegicus PubMed
390827Ensor, C.M.; Zhang, H.; Tai, H.H.Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lungBiochem. J.330103-1081998Bos taurus, Sus scrofa-
390828Clish, C.B.; Levy, B.D.; Chiang, N.; Tai, H.H.; Serhan, C.N.Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-oxoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammationJ. Biol. Chem.27525372-253802000Sus scrofa PubMed
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