Information on EC 1.13.12.3 - tryptophan 2-monooxygenase:
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The expected taxonomic range for this enzyme is: Proteobacteria

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EC NUMBERCOMMENTARY
1.13.12.3-

RECOMMENDED NAMEGeneOntology No.
tryptophan 2-monooxygenaseGO:0050361

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
L-tryptophan + O2 = (indol-3-yl)acetamide + CO2 + H2O
show the reaction diagram		----

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
oxidation----
oxidative decarboxylation----
redox reaction----
reduction----

PATHWAYKEGG LinkMetaCyc Link
indole-3-acetate biosynthesis III (bacteria)-PWY-3161
Tryptophan metabolism00380 -

SYSTEMATIC NAMEIUBMB Comments
L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)-

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
oxygenase, tryptophan 2-mono-----

CAS REGISTRY NUMBERCOMMENTARY
37256-65-8-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Agrobacterium rhizogenes-439349--Manually annotated by BRENDA team
Agrobacterium tumefaciensenzyme is a product of the T-DNA tns-1 gene of the octopine-type plasmid pTiAGNC439344--Manually annotated by BRENDA team
Pseudomonas savastanoi-439341, 439343, 439344, 439345, 439346, 439347, 439348, 654682, 654683--Manually annotated by BRENDA team
Pseudomonas savastanoievidence for extrachromosomal nature of gene involved in indole-3-acetic acid synthesis439342--Manually annotated by BRENDA team
Pseudomonas savastanoirecombinant672116--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
5-hydroxytryptophan + O25-hydroxyindole-3-acetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi-at 17% the rate of that for L-tryptophan439341--?
5-methyltryptophan + O25-methylindole-3-acetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi--439342--?
D,L-3-phenyl-2-hydrazinopropanoic acid + O22-phenylacetohydrazide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi--439347--?
D,L-3-pyridylalanine + O22-pyridylacetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi--439347--?
D,L-N-methyl-phenylalanine + O2N-methyl-2-phenylacetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi--439347--?
L-alanine + O2acetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi--439347--?
L-alanine + O2acetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi-oxidation of alanine occurrs through a hydride transfer mechanism672116--?
L-methionine + O23-(methylthio)propanamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi--439347--?
L-phenylalanine + O2phenylacetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi--439347--?
L-phenylalanine + O2phenylacetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi-weak activity439341--?
L-tryptophan + O2indole-3-acetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi--439342, 439343, 439344, 439345, 439347, 439348, 654682, 654683--?
L-tryptophan + O2indole-3-acetamide + CO2 + H2O
show the reaction diagram		Agrobacterium rhizogenes--439349--?
L-tryptophan + O2indole-3-acetamide + CO2 + H2O
show the reaction diagram		Agrobacterium tumefaciens--439344--?
L-tryptophan + O2indole-3-acetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi-specific for L-isomer of tryptophan439341--?
L-tryptophan + O2?
show the reaction diagram		Pseudomonas savastanoi-oxidative decarboxylation of L-tryptophan during the biosynthesis of indoleacetic acid672116--?
L-tyrosine + O24-hydroxyphenylacetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi-weak activity439341--?
additional information?-Pseudomonas savastanoi-no activity with: indole-3-pyruvate, indole-3-acetaldehyde, alpha-methyltryptophan, indole-3-acetic acid439341---

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
L-tryptophan + O2indole-3-acetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi--439342, 439343, 439344, 439345, 439347--
L-tryptophan + O2indole-3-acetamide + CO2 + H2O
show the reaction diagram		Agrobacterium tumefaciens--439344--
L-tryptophan + O2indole-3-acetamide + CO2 + H2O
show the reaction diagram		Pseudomonas savastanoi-specific for L-isomer of tryptophan439341--
L-tryptophan + O2?
show the reaction diagram		Pseudomonas savastanoi-oxidative decarboxylation of L-tryptophan during the biosynthesis of indoleacetic acid672116--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
FADPseudomonas savastanoi-enzyme contains 0.73 FAD molecules per subunit, addition of FAD to partially purified preparation has no effect on activity439343 2D-image
FADPseudomonas savastanoi--439346, 439347, 439348, 672116 2D-image

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
No entries in this field

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
2-mercaptoethanolPseudomonas savastanoi-weak439341 2D-image
2-methyl methanethiolsulfonatePseudomonas savastanoi--439347 2D-image
2-Oxo-3-pentynoatePseudomonas savastanoi--439348 2D-image
3-IndoleacetamidePseudomonas savastanoi--654682 2D-image
3-indolepyruvatePseudomonas savastanoi--654682 2D-image
BaCl2Pseudomonas savastanoi-weak439341 2D-image
CaCl2Pseudomonas savastanoi-little or no effect439341 2D-image
CuCl2Pseudomonas savastanoi--439341 2D-image
D-methioninePseudomonas savastanoi-competitive inhibition439347 2D-image
D-phenylalaninePseudomonas savastanoi-competitive inhibition439347 2D-image
D-tryptophanPseudomonas savastanoi-weak439341 2D-image
D-tryptophanPseudomonas savastanoi-competitive inhibitor439347 2D-image
DiethylpyrocarbonatePseudomonas savastanoi--439347 2D-image
diethylthiocarbonatePseudomonas savastanoi--439347 2D-image
EDTAPseudomonas savastanoi-little or no effect439341 2D-image
HgCl2Pseudomonas savastanoi--439341 2D-image
Hydrocinnamic acidPseudomonas savastanoi-competitive inhibition439347 2D-image
hydroxylaminePseudomonas savastanoi--439341 2D-image
Indole-3-acetaldehydePseudomonas savastanoi-weak439341 2D-image
Indole-3-acetamidePseudomonas savastanoi-end product inhibition439341, 439343 2D-image
Indole-3-acetamidePseudomonas savastanoi--439347, 654683 2D-image
indole-3-acetic acidPseudomonas savastanoi--439341, 439343, 439347 2D-image
Indole-3-pyruvatePseudomonas savastanoi--654683 2D-image
iodoacetamidePseudomonas savastanoi--439341 2D-image
IsoniazidPseudomonas savastanoi--439341 2D-image
K3Fe(CN)6Pseudomonas savastanoi-weak439341 2D-image
KCNPseudomonas savastanoi-little or no effect439341 2D-image
L-cysteinePseudomonas savastanoi--439341 2D-image
L-glutathionePseudomonas savastanoi-reduced439341 2D-image
N-ethylmaleimidePseudomonas savastanoi--439347 2D-image
phenylacetamidePseudomonas savastanoi-competitive inhibition439347 2D-image
PhenylethylaminePseudomonas savastanoi-competitive inhibition439347 2D-image
phenyllactic acidPseudomonas savastanoi-competitive inhibition439347 2D-image
Phenylpyruvic acidPseudomonas savastanoi-competitive inhibition439347 2D-image
QuinacrinePseudomonas savastanoi-weak439341 2D-image
SemicarbazidePseudomonas savastanoi--439341 2D-image
tryptaminePseudomonas savastanoi-competitive inhibition439347 2D-image
VinylglycinePseudomonas savastanoi--439347 2D-image

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
1.3-D,L-3-phenyl-2-hydrazinopropanoic acidPseudomonas savastanoi--439347 2D-image
32-D,L-3-pyridylalaninePseudomonas savastanoi--439347 2D-image
22.6-D,L-N-methyl-phenylalaninePseudomonas savastanoi--439347 2D-image
22.6-L-alaninePseudomonas savastanoi--439347 2D-image
22.4-L-methioninePseudomonas savastanoi--439347 2D-image
2.4-L-phenylalaninePseudomonas savastanoi--439347 2D-image
0.036-L-tryptophanPseudomonas savastanoi--439347 2D-image
0.04-L-tryptophanPseudomonas savastanoi-pH 8.3, 25°C, wild-type654683 2D-image
0.05-L-tryptophanPseudomonas savastanoi--439343 2D-image
1-L-tryptophanPseudomonas savastanoi-pH 8.3, 25°C, mutant Y413F654683 2D-image
1.48-L-tryptophanPseudomonas savastanoi-pH 8.3, 25°C, mutant Y413A654683 2D-image
0.067-O2Pseudomonas savastanoi-pH 8.3, 25°C, mutant R98A654682 2D-image
0.09-O2Pseudomonas savastanoi-pH 8.3, 25°C, wild-type654682, 654683 2D-image
0.12-O2Pseudomonas savastanoi-pH 8.3, 25°C, mutant Y413A654683 2D-image
0.14-O2Pseudomonas savastanoi-pH 8.3, 25°C, mutant R98K654682 2D-image
0.22-O2Pseudomonas savastanoi-pH 8.3, 25°C, mutant Y413F654683 2D-image
0.04-tryptophanPseudomonas savastanoi-pH 8.3, 25°C, wild-type654682 2D-image
3.3-tryptophanPseudomonas savastanoi-pH 8.3, 25°C, mutant R98A654682 2D-image
30-tryptophanPseudomonas savastanoi-pH 8.3, 25°C, mutant R98K654682 2D-image

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.0000167-D,L-3-phenyl-2-hydrazinopropanoic acidPseudomonas savastanoi--439347 2D-image
0.00075-D,L-3-pyridylalaninePseudomonas savastanoi--439347 2D-image
0.000317-D,L-N-methyl-phenylalaninePseudomonas savastanoi--439347 2D-image
0.000317-L-alaninePseudomonas savastanoi--439347 2D-image
0.00155-L-methioninePseudomonas savastanoi--439347 2D-image
0.00305-L-phenylalaninePseudomonas savastanoi--439347 2D-image
0.00367-L-tryptophanPseudomonas savastanoi--439347 2D-image
0.69-L-tryptophanPseudomonas savastanoi-pH 8.3, 25°C, mutant Y413A654683 2D-image
4-L-tryptophanPseudomonas savastanoi-pH 8.3, 25°C, mutant Y413F654683 2D-image
13.2-L-tryptophanPseudomonas savastanoi-pH 8.3, 25°C, wild-type654683 2D-image
0.21-tryptophanPseudomonas savastanoi-pH 8.3, 25°C, mutant R98A654682 2D-image
1.05-tryptophanPseudomonas savastanoi-pH 8.3, 25°C, mutant R98K654682 2D-image
13.2-tryptophanPseudomonas savastanoi-pH 8.3, 25°C, wild-type654682 2D-image

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
16-3-IndoleacetamidePseudomonas savastanoi-pH 8.3, 25°C, wild-type654682 2D-image
20-3-IndoleacetamidePseudomonas savastanoi-pH 8.3, 25°C, mutant R98K654682 2D-image
45-3-IndoleacetamidePseudomonas savastanoi-pH 8.3, 25°C, mutant R98A654682 2D-image
40-3-indolepyruvatePseudomonas savastanoi-pH 8.3, 25°C, wild-type654682 2D-image
471-3-indolepyruvatePseudomonas savastanoi-pH 8.3, 25°C, mutant R98K654682 2D-image
670-3-indolepyruvatePseudomonas savastanoi-pH 8.3, 25°C, mutant R98A654682 2D-image
0.69-Indole-3-acetamidePseudomonas savastanoi-pH 8.3, 25°C, mutant Y413A654683 2D-image
4-Indole-3-acetamidePseudomonas savastanoi-pH 8.3, 25°C, mutant Y413F654683 2D-image
13.2-Indole-3-acetamidePseudomonas savastanoi-pH 8.3, 25°C, wild-type654683 2D-image
0.69-Indole-3-pyruvatePseudomonas savastanoi-pH 8.3, 25°C, mutant Y413A654683 2D-image
4-Indole-3-pyruvatePseudomonas savastanoi-pH 8.3, 25°C, mutant Y413F654683 2D-image
13.2-Indole-3-pyruvatePseudomonas savastanoi-pH 8.3, 25°C, wild-type654683 2D-image

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
0.25-Pseudomonas savastanoi--439341
12.7-Pseudomonas savastanoi--439347
13.28-Pseudomonas savastanoi--439343

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
7.29.2Pseudomonas savastanoi--439341

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
4.511Pseudomonas savastanoi--439347
5.510Pseudomonas savastanoi-pH 5.5: about 50% of activity maximum, pH 10: about 55% of activity maximum439341

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
25-Pseudomonas savastanoi-assay at439341

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
3545Pseudomonas savastanoi--439347

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
No entries in this field

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
No entries in this field

PDBSCOPCATHORGANISM
4iv9, downloadSCOP (4iv9)CATH (4iv9)Pseudomonas syringae pv. savastanoi

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
61780-Pseudomonas savastanoi-calculation from nucleotide sequence439344
62000-Pseudomonas savastanoi-amino acid composition439343
85000-Pseudomonas savastanoi-gel filtration439343

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
monomerPseudomonas savastanoi-1 * 62000, SDS-PAGE439343

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
55-Pseudomonas savastanoi-pH 7.4, protein concentration above 4 mg/ml, 2 min, stable, 40% loss of activity after 5 min439341

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
FAD has no effect on stabilityPseudomonas savastanoi-439343

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-10°C, protein concentration 4 mg/ml, 2 months, less than 10% loss of activityPseudomonas savastanoi-439341
-10°C, protein concentration less than 0.3 mg/ml, 40% loss of activity after 24 hPseudomonas savastanoi-439341
-20°C, several weeks without significant loss in activityPseudomonas savastanoi-439347
4°C, several weeks without significant loss in activityPseudomonas savastanoi-439347

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-Pseudomonas savastanoi-439341, 439343, 439347
recombinantPseudomonas savastanoi-672116

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
expression in Escherichia coliAgrobacterium rhizogenes, Agrobacterium rhizogenes 30148-439349
-Pseudomonas savastanoi-439347, 439348
evidence for extrachromosomal nature of gene involved in indole-3-acetic acid synthesisPseudomonas savastanoi-439342
expression in Escherichia coliPseudomonas savastanoi-439345

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
C339APseudomonas savastanoi-slight decrease in activity with tryptophan or methionine439346
C511SPseudomonas savastanoi-high decrease in activity with tryptophan or methionine439346
H338NPseudomonas savastanoi-slight decrease in activity with tryptophan or methionine439346
R98APseudomonas savastanoi-decrease in Vmax, increase in Km-value of tryptophan654682
R98KPseudomonas savastanoi-decrease in Vmax, increase in Km-value of tryptophan654682
Y413APseudomonas savastanoi-200fold reduction in first-order rate constant for reduction, 33fold decrease in rate constant for oxidation, conversion of enzyme to oxidase654683
Y413FPseudomonas savastanoi-35fold reduction in first-order rate constant for reduction, 11fold decrease in rate constant for oxidation, conversion of enzyme to oxidase654683

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISM (UNIPROT ACCESSION NO.)LINK TO PUBMEDSOURCE
439341Kosuge, T.; Heskett, M.G.; Wilson, E.E.Microbial synthesis and degradation of indole-3-acetic acid. I. The conversion of L-tryptophan to indole-3-acetamide by an enzyme system from Pseudomonas savastanoiJ. Biol. Chem.2413738-37441966Pseudomonas savastanoi PubMed
439342Comai, L.; Kosuge, T.Involvement of plasmid deoxyribonucleic acid in indoleacetic acid synthesis in Pseudomonas savastanoiJ. Bacteriol.143950-9571980Pseudomonas savastanoi PubMed
439343Hutcheson, S.W.; Kosuge, T.Regulation of 3-indoleacetic acid production in Pseudomonas syringae pv. savastanoi. Purification and properties of tryptophan 2-monooxygenaseJ. Biol. Chem.2606281-62871985Pseudomonas savastanoi PubMed
439344Yamada, T.; Palm, C.J.; Brooks, B.; Kosuge, T.Nucleotide sequences of the Pseudomonas savastanoi indoleacetic acid genes show homology with Agrobacterium tumefaciens T-DNAProc. Natl. Acad. Sci. USA826522-65261985Agrobacterium tumefaciens, Pseudomonas savastanoi PubMed
439345Comai, L.; Kosuge, T.Cloning characterization of iaaM, a virulence determinant of Pseudomonas savastanoiJ. Bacteriol.14940-461982Pseudomonas savastanoi PubMed
439346Sobrado, P.; Fitzpatrick, P.F.Analysis of the roles of amino acid residues in the flavoprotein tryptophan 2-monooxygenase modified by 2-oxo-3-pentynoate: characterization of His338, Cys339, and Cys511 mutant enzymesArch. Biochem. Biophys.40224-302002Pseudomonas savastanoi PubMed
439347Emanuele, J.J.; Heasley, C.J.; Fitzpatrick, P.F.Purification and characterization of the flavoprotein tryptophan 2-monooxygenase expressed at high levels in Escherichia coliArch. Biochem. Biophys.316241-2481995Pseudomonas savastanoi PubMed
439348Gadda, G.; Dangott, L.J.; Johnson, W.H., Jr.; Whitman, C.P.; Fitzpatrick, P.F.Characterization of 2-oxo-3-pentynoate as an active-site-directed inactivator of flavoprotein oxidase: identification of active-site peptides in tryptophan 2-monooxygenaseBiochemistry385822-58281999Pseudomonas savastanoi PubMed
439349Lemcke, K.; Prinsen, E.; van Onckelen, H.; Schmulling, T.The ORF8 gene product of Agrobacterium rhizogenes TL-DNA has tryptophan 2-monooxygenase activityMol. Plant Microbe Interact.13787-7902000Agrobacterium rhizogenes PubMed
654682Sobrado, P.; Fitzpatrick, P.F.Analysis of the role of the active site residue Arg98 in the flavoprotein tryptophan 2-monooxygenase, a member of the L-amino oxidase familyBiochemistry4213826-138322003Pseudomonas savastanoi PubMed
654683Sobrado, P.; Fitzpatrick, P.F.Identification of Tyr413 as an active site residue in the flavoprotein tryptophan 2-monooxygenase and analysis of its contribution to catalysisBiochemistry4213833-138382003Pseudomonas savastanoi PubMed
672116Ralph, E.C.; Anderson, M.A.; Cleland, W.W.; Fitzpatrick, P.F.Mechanistic studies of the flavoenzyme tryptophan 2-monooxygenase: deuterium and (15)N kinetic isotope effects on alanine oxidation by an l-amino acid oxidaseBiochemistry4515844-158522006Pseudomonas savastanoi PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 1.13.12.3)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)