Information on EC 1.11.1.12 - phospholipid-hydroperoxide glutathione peroxidase:
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EC NUMBERCOMMENTARY
1.11.1.12-

RECOMMENDED NAMEGeneOntology No.
phospholipid-hydroperoxide glutathione peroxidaseGO:0047066

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O
show the reaction diagram		a protein containing a selenocysteine residue. The products of EC 1.13.11.12 on phospholipids can act as acceptor, H2O2 can also act, but much more slowly. The product of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptor; H2O2 can also act, but much more slowly (cf. EC1.11.1.9 glutathione peroxidase)---
2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O
show the reaction diagram		tert-uni ping-pong mechanismSus scrofa-394864
2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O
show the reaction diagram		ping-pong mechanismSus scrofa-394865
2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O
show the reaction diagram		ping-pong mechanism with formation of ternary complexesSus scrofa-394867
2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O
show the reaction diagram		tert-uni ping-pong mechanismHomo sapiens-394873

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
oxidation----
oxidationMomordica charantiaQ8W259-696173
oxidationMus musculus--696435
oxidationanimal--696970
oxidationBombus ignitusC3VVL8-697468
oxidationCyprinus carpio--697470
oxidationRattus norvegicus--697778
oxidationTaiwanofungus camphoratusB8K1J5-698037
oxidationHomo sapiens--698045
oxidationOryza sativa--701033
oxidationSaccharomyces cerevisiae--701118
oxidationSchistosoma mansoni--701138
oxidationBos taurus--701272
redox reaction----
reduction----
reductionHomo sapiens-GPx4 can catalyze the GSH-dependent two-electron reduction of various phospholipid-, cholesterol-, and cholesteryl ester-derived hydroperoxides in solubilized as well as membrane- or lipoprotein-bound form675048
reductionRaphanus sativus-GSH-dependent peroxidase activity with the largest affinity to and the highest catalytic efficiency on phosphatidylcholine hydroperoxide676554
reductionMomordica charantiaQ8W259-696173
reductionMus musculus--696435
reductionanimal--696970
reductionBombus ignitusC3VVL8-697468
reductionCyprinus carpio--697470
reductionRattus norvegicus--697778
reductionTaiwanofungus camphoratusB8K1J5-698037
reductionHomo sapiens--698045
reductionOryza sativa--701033
reductionSaccharomyces cerevisiae--701118
reductionSchistosoma mansoni--701138
reductionBos taurus--701272

PATHWAYKEGG LinkMetaCyc Link
glutathione redox reactions I-PWY-4081

SYSTEMATIC NAMEIUBMB Comments
glutathione:lipid-hydroperoxide oxidoreductaseA protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptor; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase).

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
AC-PHGPxTaiwanofungus camphoratusB8K1J5-698037
Bi-PHGPxBombus ignitusC3VVL8-697468
class 4 GPxSchistosoma mansoni--701138
CsGPx1Clonorchis sinensisA0SWV9, A0SWW0, A0SWW1, A0SWW2-687186
CsGPx2Clonorchis sinensisA0SWV9, A0SWW0, A0SWW1, A0SWW2-687186
CsGPx3Clonorchis sinensisA0SWV9, A0SWW0, A0SWW1, A0SWW2-687186
CsGPx4Clonorchis sinensisA0SWV9, A0SWW0, A0SWW1, A0SWW2-687186
DMPHGPxDrosophila melanogaster--659647
glutathione peroxidase 4Mus musculus--696435
glutathione peroxidase-4Homo sapiens--698045
glutathione-dependent phospholipid peroxidaseSaccharomyces cerevisiae--701118
GPXHomo sapiens--673807
GPx-4Homo sapiens--672372, 688924
GPx-4Bos taurusQ9N2J2-673343
GPX3Saccharomyces cerevisiae--701118
GPx4Mus musculus--674370, 674598, 696435
GPx4Homo sapiens--675048, 685185, 698045
GPx4Mus musculusO70325; 686888
GPx4Bombus ignitusC3VVL8-697468
GPx4Rattus norvegicus--701060
GPx4Bos taurus--701272
GPx41Hydra vulgarisQ072C7mitochondrial form673837
GPx4ACyprinus carpio--697470
GPx4BCyprinus carpio--697470
GPXhs2Solanum lycopersicum--658606
GPXle1Solanum lycopersicum--658606
hydroperoxide glutathione peroxidase----
Hyr1Saccharomyces cerevisiae--701118
Hyr1/YIR037WSaccharomyces cerevisiae--701118
non-selenocysteine PHGPxHomo sapiens--659398
NPGPxHomo sapiens--659398
nPHGPxMus musculus--675965
OsPHGPxOryza sativa--686071, 687471, 701033
peroxidation-inhibiting protein----
peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)----
PHGPX----
PHGPXHomo sapiens--658247, 658926, 671327, 671713, 673931, 675048, 685440, 686896
PHGPXRattus norvegicus--658758, 671833, 673176, 674502, 685440, 688724, 697778
PHGPXDrosophila melanogaster, Venturia canescens--659647
PHGPXBos taurus--673343, 701272
PHGPXHydra vulgarisQ072C7-673837
PHGPXMus musculus--673845, 674370, 675965, 685440, 686888, 688464, 696435
PHGPXRhipicephalus microplusQ2XW19-674008
PHGPXRaphanus sativus--676554
PHGPXSus scrofa--685440
PHGPXClonorchis sinensisA0SWV9, A0SWW0, A0SWW1, A0SWW2-687186
PHGPXanimal--696970
PHGPXBombus ignitusC3VVL8-697468
PHGPXOryza sativa--701033
PHGPXSaccharomyces cerevisiae--701118
phospholipid glutathione peroxidaseSchistosoma mansoni--701138
phospholipid hydroperoxide glutathione peroxidase----
phospholipid hydroperoxide glutathione peroxidaseHomo sapiens--658247, 658926, 671327, 671713, 673807, 673931, 685440, 686896
phospholipid hydroperoxide glutathione peroxidaseRattus norvegicus--658758, 671833, 673176, 674502, 685440, 697778, 701060
phospholipid hydroperoxide glutathione peroxidaseBos taurus--673343, 701272
phospholipid hydroperoxide glutathione peroxidaseHydra vulgarisQ072C7-673837
phospholipid hydroperoxide glutathione peroxidaseMus musculus--673845, 674370, 674598, 675965, 685440, 686888, 696435
phospholipid hydroperoxide glutathione peroxidaseRaphanus sativus--676554
phospholipid hydroperoxide glutathione peroxidaseSus scrofa--685440
phospholipid hydroperoxide glutathione peroxidaseMomordica charantiaQ8W259-696173
phospholipid hydroperoxide glutathione peroxidaseanimal--696970
phospholipid hydroperoxide glutathione peroxidaseTaiwanofungus camphoratusB8K1J5-698037
phospholipid hydroperoxide glutathione peroxidaseOryza sativa--701033
phospholipid hydroperoxide glutathione peroxidase ACyprinus carpio--697470
phospholipid hydroperoxide glutathione peroxidase BCyprinus carpio--697470
phospholipid hydroperoxide glutathione peroxidase-4Homo sapiensP36969-685185
phospholipid-hydroperoxide glutathione peroxidaseBombus ignitusC3VVL8-697468
phospholipid-hydroperoxide glutathione peroxidasesDrosophila melanogaster, Venturia canescens--659647
selenium-dependent glutathione peroxidase type-4Homo sapiens--675048
seleno GPxSchistosoma mansoni--701138
selenoperoxidaseHomo sapiens--675048
selenoprotein PHomo sapiens--394873
sperm nucleus-specific glutathione peroxidaseMus musculus--675965
type-4 glutathione peroxidaseRattus norvegicus--701060
VcPHGPxVenturia canescens--659647
McPHGPxMomordica charantiaQ8W259-696173
additional informationCitrus sinensis-salt-sensitive cell line is inducible by abscisic acid and 10fold by NaCl 0.2 M, salt-tolerant cell line is not394872

CAS REGISTRY NUMBERCOMMENTARY
97089-70-8-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
animalinvertebrate animals, the GPx genes are isolated from various platyhelminths via in silico screening696970--Manually annotated by BRENDA team
Bombus ignitus-697468C3VVL8UniProtManually annotated by BRENDA team
Bos taurus-394867, 394876--Manually annotated by BRENDA team
Bos taurus-673343Q9N2J2UniprotManually annotated by BRENDA team
Bos taurusbull, three Italian beef breeds, Chianina, Marchigiana, Romagnola701272--Manually annotated by BRENDA team
Canis lupus familiaris-394867--Manually annotated by BRENDA team
Citrus sinensisShamouti orange, encoding gene csa394872--Manually annotated by BRENDA team
Clonorchis sinensis-687186A0SWV9, A0SWW0, A0SWW1, A0SWW2SwissProtManually annotated by BRENDA team
Cyprinus carpio-697470--Manually annotated by BRENDA team
Drosophila melanogaster-659647--Manually annotated by BRENDA team
Homo sapiens-394873, 394878, 394879, 658247, 658926, 659398, 671327, 671713, 672372, 673807, 673931, 675048, 685440, 686896, 688924, 698045--Manually annotated by BRENDA team
Homo sapiens-685185P36969SwissProtManually annotated by BRENDA team
Hydra vulgarismitochondrial enzyme673837Q072C7TrEMBLManually annotated by BRENDA team
Mesocricetus auratus-658251--Manually annotated by BRENDA team
Momordica charantia-696173Q8W259UniProtManually annotated by BRENDA team
Mus musculus-673845, 674370, 674598, 675965, 685440, 686888, 696435--Manually annotated by BRENDA team
Mus musculus-686405O70325SwissProtManually annotated by BRENDA team
Mus musculusmale688464--Manually annotated by BRENDA team
Mus musculustransgenic mice in which PHGPx is overexpressed solely in the mitochondrion686888O70325SwissProtManually annotated by BRENDA team
Oryza sativa-686071, 687471, 701033--Manually annotated by BRENDA team
Raphanus sativus-676554--Manually annotated by BRENDA team
Rattus norvegicus-394866, 394867, 394871, 394877, 394880, 394883, 658758, 671833, 673176, 685440, 688724, 689838, 697778, 701060--Manually annotated by BRENDA team
Rattus norvegicus-674502P36970SwissProtManually annotated by BRENDA team
Rhipicephalus micropluscattle tick674008Q2XW19TrEMBLManually annotated by BRENDA team
Saccharomyces cerevisiae-701118--Manually annotated by BRENDA team
Saccharomyces cerevisiaegenes GPX1, GPX2 and GPX3394874--Manually annotated by BRENDA team
Schistosoma mansoni-701138--Manually annotated by BRENDA team
Schistosoma mansoniblood fluke, parasite platyhelminth394882--Manually annotated by BRENDA team
Solanum lycopersicum-658606--Manually annotated by BRENDA team
Sus scrofa-394864, 394865, 394867, 394868, 394869, 394870, 394881, 685440--Manually annotated by BRENDA team
Taiwanofungus camphoratus-698037B8K1J5UniProtManually annotated by BRENDA team
Trypanosoma cruziAmerican trypanosome394875--Manually annotated by BRENDA team
Venturia canescens-659647--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
glutathione + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-3-phosphatidylcholine?
show the reaction diagram		Homo sapiens--394873, 394878--?
glutathione + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-L-3-phosphatidylcholine?
show the reaction diagram		Oryza sativa--687471--?
glutathione + 3beta-hydroxycholest-5-ene-7alpha-hydroperoxidecholest-5-ene-3beta,7alpha-diol + ?
show the reaction diagram		Rattus norvegicus--701060--?
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Mus musculus--696435--?
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Homo sapiens--698045--?
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Rattus norvegicus--697778--?
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Bos taurus--701272--?
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Schistosoma mansoni--701138--?
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Cyprinus carpio--697470--?
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		animal--696970--?
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Bombus ignitusC3VVL8-697468--?
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Momordica charantiaQ8W259-696173--?
glutathione + cardiolipine?
show the reaction diagram		Rattus norvegicus--394883--?
glutathione + cardiolipine?
show the reaction diagram		Sus scrofa--394864--?
glutathione + cholesterol hydroperoxide?
show the reaction diagram		Homo sapiens--675048--?
glutathione + cholesterol hydroperoxides?
show the reaction diagram		Rattus norvegicus, Sus scrofa--394867--?
glutathione + cholesterol hydroperoxides?
show the reaction diagram		Sus scrofa--394870, 394881--?
glutathione + cholesterol hydroperoxides?
show the reaction diagram		Bos taurus, Canis lupus familiaris--394867--?
glutathione + cumene hydroperoxide?
show the reaction diagram		Homo sapiens--394878--?
glutathione + cumene hydroperoxide?
show the reaction diagram		Rattus norvegicus--394871, 394880, 701060--?
glutathione + cumene hydroperoxide?
show the reaction diagram		Sus scrofa--394864, 394865, 394868--?
glutathione + cumene hydroperoxide?
show the reaction diagram		Trypanosoma cruzi--394875--?
glutathione + cumene hydroperoxide?
show the reaction diagram		Schistosoma mansoni--394882--?
glutathione + cumene hydroperoxide?
show the reaction diagram		Bos taurus-no activity394876---
glutathione + dilinoleoyl phosphatidylcholine hydroperoxide?
show the reaction diagram		Homo sapiens--394879--?
glutathione + dilinoleoyl phosphatidylcholine hydroperoxide?
show the reaction diagram		Sus scrofa-and derivatives of dilinoyl phosphatidylcholine hydroperoxide394864--?
glutathione + fatty acid hydroperoxides?
show the reaction diagram		Sus scrofa--394867--?
glutathione + H2O2?
show the reaction diagram		Homo sapiens--394878--?
glutathione + H2O2?
show the reaction diagram		Rattus norvegicus--394867, 394871, 394880--?
glutathione + H2O2?
show the reaction diagram		Sus scrofa--394864, 394865, 394867--?
glutathione + H2O2?
show the reaction diagram		Bos taurus, Canis lupus familiaris--394867--?
glutathione + H2O2?
show the reaction diagram		Trypanosoma cruzi--394875--?
glutathione + H2O2?
show the reaction diagram		Raphanus sativus--676554--?
glutathione + H2O2?
show the reaction diagram		Schistosoma mansoni--394882--?
glutathione + H2O2?
show the reaction diagram		Oryza sativa--687471--?
glutathione + H2O2?
show the reaction diagram		Momordica charantiaQ8W259-696173--?
glutathione + H2O2?
show the reaction diagram		Homo sapiens-no activity394873---
glutathione + H2O2?
show the reaction diagram		Bos taurus-no activity394876---
glutathione + H2O2?
show the reaction diagram		Schistosoma mansoni-activity assay701138--?
glutathione + H2O2?
show the reaction diagram		Bombus ignitusC3VVL8activity assay697468--?
glutathione + KKSQCCQQKT?
show the reaction diagram		Rattus norvegicusP36970-674502--?
glutathione + KPPCCPPK?
show the reaction diagram		Rattus norvegicusP36970-674502--?
glutathione + L-alpha-phosphatidylcholine hydroperoxide?
show the reaction diagram		Homo sapiens--672372, 675048--?
glutathione + L-alpha-phosphatidylcholine hydroperoxide?
show the reaction diagram		Rattus norvegicus--394871, 394880, 671833, 701060--?
glutathione + L-alpha-phosphatidylcholine hydroperoxide?
show the reaction diagram		Sus scrofa--394864, 394865, 394868--?
glutathione + L-alpha-phosphatidylcholine hydroperoxide?
show the reaction diagram		Bos taurusQ9N2J2-673343--?
glutathione + L-alpha-phosphatidylcholine hydroperoxide?
show the reaction diagram		Trypanosoma cruzi--394875--?
glutathione + L-alpha-phosphatidylcholine hydroperoxide?
show the reaction diagram		Schistosoma mansoni--394882--?
glutathione + L-alpha-phosphatidylcholine hydroperoxide?
show the reaction diagram		Mus musculusO70325L-alpha-phosphatidylcholine hydroperoxide is a specific substrate of GPx4686888--?
glutathione + LDL hydroperoxides?
show the reaction diagram		Rattus norvegicus--394880--?
glutathione + linoleic acid hydroperoxide?
show the reaction diagram		Homo sapiens--394878--?
glutathione + linoleic acid hydroperoxide?
show the reaction diagram		Sus scrofa--394864, 394865--?
glutathione + linoleic acid hydroperoxide?
show the reaction diagram		Trypanosoma cruzi--394875--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Mus musculus--673845, 674370--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Homo sapiens--394878, 394879, 673931--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Rattus norvegicus--394867, 394871, 394880, 394883--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Sus scrofa--394869---
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Sus scrofa--394864, 394865, 394868--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Sus scrofa--394870--ir
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Saccharomyces cerevisiae--394874--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Bos taurus--394867, 394876--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Canis lupus familiaris--394867--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Trypanosoma cruzi--394875--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Schistosoma mansoni--394882--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Citrus sinensis--394872--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Hydra vulgarisQ072C7-673837--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Homo sapiens-dithiothreitol, 2-mercaptoethanol, cysteine and homocysteine also serve as reducing agents394873--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Sus scrofa-reduces hydroperoxides of phosphatidylcholine and cholesteryllinolate alone or associated to oxidized LDL and oxidized HDL394881--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Sus scrofa-wide specificity for lipid hydroperoxides394867--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Rattus norvegicus-dithiothreitol and dithioerythritol are 3fold more active than glutathione, while 2-mercaptoethanol and L-cysteine show 50% and 20% of the activity with glutathione as reductants, respectively394880--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Sus scrofa-the oxidized active site of the enzyme can also be reduced by mercaptoethanol394867--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Homo sapiens-protection of biomembranes against oxidative damage394873, 394878--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Rattus norvegicus, Sus scrofa-protection of biomembranes against oxidative damage394867--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Sus scrofa-protection of biomembranes against oxidative damage394868--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Saccharomyces cerevisiae-protection of biomembranes against oxidative damage394874--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Bos taurus, Canis lupus familiaris-protection of biomembranes against oxidative damage394867--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Sus scrofa-enzyme reduces amphiphilic peroxides, possibly at the water-lipid interface394865--?
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Sus scrofa-role in cellular detoxification of a wide variety of lipid hydroperoxides in membranes and internalized lipoproteins394870--?
glutathione + phosphatidic acid hydroperoxide?
show the reaction diagram		Sus scrofa--394864--?
glutathione + phosphatidylcholine hydroperoxide?
show the reaction diagram		Raphanus sativus--676554--?
glutathione + phosphatidylcholine hydroperoxide?
show the reaction diagram		Momordica charantiaQ8W259-696173--?
glutathione + phosphatidylcholine hydroperoxide?
show the reaction diagram		Homo sapiens-activity assay698045--?
glutathione + phosphatidylcholine hydroperoxide?
show the reaction diagram		Bos taurus-activity assay701272--?
glutathione + phosphatidylcholine hydroperoxide?
show the reaction diagram		Bombus ignitusC3VVL8activity assay697468--?
glutathione + phosphatidylethanolamine hydroperoxide?
show the reaction diagram		Sus scrofa--394864--?
glutathione + phosphatidylserine hydroperoxide?
show the reaction diagram		Sus scrofa--394864--?
glutathione + phospholipid hydroperoxides?
show the reaction diagram		Rattus norvegicus--394867, 394871--?
glutathione + phospholipid hydroperoxides?
show the reaction diagram		Sus scrofa--394867, 394881--?
glutathione + phospholipid hydroperoxides?
show the reaction diagram		Bos taurus--394867, 394876--?
glutathione + PKPPCCPPKP?
show the reaction diagram		Rattus norvegicusP36970-674502--?
glutathione + PKSPCCPPKP?
show the reaction diagram		Rattus norvegicusP36970-674502--?
glutathione + PKSPCCPPKS?
show the reaction diagram		Rattus norvegicusP36970-674502--?
glutathione + PPCCPP?
show the reaction diagram		Rattus norvegicusP36970-674502--?
glutathione + PPKPCCPPKP?
show the reaction diagram		Rattus norvegicusP36970-674502--?
glutathione + PPPPCCPPPP?
show the reaction diagram		Rattus norvegicusP36970-674502--?
glutathione + QKPPCCPKSP?
show the reaction diagram		Rattus norvegicusP36970-674502--?
glutathione + QKSPCCPKSP?
show the reaction diagram		Rattus norvegicusP36970-674502--?
glutathione + t-butyl hydroperoxide?
show the reaction diagram		Raphanus sativus--676554--?
glutathione + tert-butyl hydroperoxide?
show the reaction diagram		Rattus norvegicus--394867, 394880, 394883--?
glutathione + tert-butyl hydroperoxide?
show the reaction diagram		Sus scrofa--394867, 394868--?
glutathione + tert-butyl hydroperoxide?
show the reaction diagram		Bos taurus, Canis lupus familiaris--394867--?
glutathione + tert-butyl hydroperoxide?
show the reaction diagram		Trypanosoma cruzi--394875--?
glutathione + tert-butyl hydroperoxide?
show the reaction diagram		Oryza sativa--687471--?
glutathione + tert-butyl hydroperoxide?
show the reaction diagram		Citrus sinensis--394872--?
glutathione + tert-butyl hydroperoxide?
show the reaction diagram		Homo sapiens-no activity394873---
glutathione + tert-butyl-hydroperoxide?
show the reaction diagram		Momordica charantiaQ8W259-696173--?
glutathione + tert-butyl-hydroperoxide?
show the reaction diagram		Schistosoma mansoni-activity assay701138--?
glutathione + tert-butylhydroperoxide?
show the reaction diagram		Homo sapiens--673807--?
GSH + cumene hydroperoxideGSSG + ?
show the reaction diagram		Drosophila melanogaster--659647--?
GSH + cumene hydroperoxideGSSG + ?
show the reaction diagram		Solanum lycopersicum--658606--?
GSH + H2O2GSSG + ?
show the reaction diagram		Drosophila melanogaster-about 50% of the activity with cumene hydroperoxide659647--?
GSH + linoleic acid hydroperoxideGSSG + ?
show the reaction diagram		Solanum lycopersicum--658606--?
GSH + phosphatidylcholine dilinoleoyl hydroperoxideGSSG + ?
show the reaction diagram		Solanum lycopersicum--658606--?
GSH + tert-butyl hydroperoxideGSSG + ?
show the reaction diagram		Solanum lycopersicum--658606--?
thioredoxin + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-L-3-phosphatidylcholine?
show the reaction diagram		Oryza sativa--687471--?
GSH + tert-butyl hydroperoxideGSSG + ?
show the reaction diagram		Drosophila melanogaster-about 80% of the activity with cumene hydroperoxide659647--?
additional information?-Rattus norvegicus, Sus scrofa, Bos taurus, Canis lupus familiaris-reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives394867---
additional information?-Homo sapiens-enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes394878---
additional information?-Rattus norvegicus, Sus scrofa-enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes394867---
additional information?-Sus scrofa-enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes394868, 394870---
additional information?-Bos taurus, Canis lupus familiaris-enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes394867---
additional information?-Homo sapiens-phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase are counterparts in the metabolism of hydroperoxy lipids394879---
additional information?-Rattus norvegicus-mitochondrial enzyme inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis394883---
additional information?-Rattus norvegicus-controlled by gonadotropin394880---
additional information?-Homo sapiens-enzyme inhibits peroxidation of microsomes394878---
additional information?-Drosophila melanogaster-in addition to a structural role, PHGPx may also be involved in the non-enzymatic protection of sperm surface against detrimental effects caused by accumulation of modified lipids659647---
additional information?-Homo sapiens-the enzyme appears to be indispensable for structural integrity of spermatozoa and to codetermine sperm motility and viability658247---
additional information?-Venturia canescens-the enzyme is not enzymatically active but may be able to interact with modified phospholipids on the membrane, thereby masking or removing potentially damaging lipids from the surface of the parasitpoid‘s eggs659647---
additional information?-Homo sapiens-the enzyme plays an essential role in breast cancer cells in alleviating oxidative stress generated from polyunsaturated fatty acid metabolism659398---
additional information?-Mesocricetus auratus-tyrosine phosphorylation of the enzyme may represent an important event in the signaling cascade associated with capacitation that may impact the regulation of hyperactivation of sperm motility and/or mitochondrial function658251---
additional information?-Solanum lycopersicum-the enzyme shows phospholipid hydroperoxide glutathione peroxidase activity and thioredoxin peroxidase activity. Thioredoxin peroxidase activity is higher than phospholipid hydroperoxidase activity in terms of efficiency and substrate affinities. No activity with glutathione + H2O2658606---
additional information?-Sus scrofa-PhGPx prevents NF-kappaB activation, oxLDL-induced proliferation and linoleic acid-induced apoptosis685440---
additional information?-Mus musculus-PHGPx-/- mice are embryonically lethal at gestation day 7.5. PHGPx+/- mice cells show decreased life span after exposure to irradiation and increased susceptibility to oxidative and genotoxic stress685440---
additional information?-Homo sapiens-GPx4 can react with H2O2 and a wide range of lipid hydroperoxides including oxidized phospholipids and cholesterol hydroperoxides698045---
additional information?-Taiwanofungus camphoratusB8K1J5PHGPx is an antioxidant enzyme that can reduce peroxidized phospholipids produced in cell membranes698037---
additional information?-Mus musculus-preferred substrates are found to be hydroperoxide groups of phosphatidylcholine and on cumene and t-butyl hydroperoxides696435---
additional information?-Oryza sativa-reduces lipid hydroperoxides in biomembranes701033---
additional information?-Saccharomyces cerevisiae-specifically detoxifies phospholipid peroxide701118---

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Mus musculus--696435--
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Homo sapiens--698045--
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Rattus norvegicus--697778--
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Bos taurus--701272--
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Schistosoma mansoni--701138--
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Cyprinus carpio--697470--
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		animal--696970--
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Bombus ignitusC3VVL8-697468--
glutathione + a lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Momordica charantiaQ8W259-696173--
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Homo sapiens--394879--
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Rattus norvegicus--394880, 394883--
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Citrus sinensis--394872--
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Homo sapiens-protection of biomembranes against oxidative damage394873, 394878--
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Rattus norvegicus, Sus scrofa-protection of biomembranes against oxidative damage394867--
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Sus scrofa-protection of biomembranes against oxidative damage394868--
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Saccharomyces cerevisiae-protection of biomembranes against oxidative damage394874--
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Bos taurus, Canis lupus familiaris-protection of biomembranes against oxidative damage394867--
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Sus scrofa-enzyme reduces amphiphilic peroxides, possibly at the water-lipid interface394865--
glutathione + lipid hydroperoxideglutathione disulfide + lipid + H2O
show the reaction diagram		Sus scrofa-role in cellular detoxification of a wide variety of lipid hydroperoxides in membranes and internalized lipoproteins394870--
additional information?-Homo sapiens-enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes394878--
additional information?-Rattus norvegicus, Sus scrofa-enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes394867--
additional information?-Sus scrofa-enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes394868, 394870--
additional information?-Bos taurus, Canis lupus familiaris-enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes394867--
additional information?-Homo sapiens-phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase are counterparts in the metabolism of hydroperoxy lipids394879--
additional information?-Rattus norvegicus-mitochondrial enzyme inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis394883--
additional information?-Rattus norvegicus-controlled by gonadotropin394880--
additional information?-Homo sapiens-enzyme inhibits peroxidation of microsomes394878--
additional information?-Drosophila melanogaster-in addition to a structural role, PHGPx may also be involved in the non-enzymatic protection of sperm surface against detrimental effects caused by accumulation of modified lipids659647--
additional information?-Homo sapiens-the enzyme appears to be indispensable for structural integrity of spermatozoa and to codetermine sperm motility and viability658247--
additional information?-Venturia canescens-the enzyme is not enzymatically active but may be able to interact with modified phospholipids on the membrane, thereby masking or removing potentially damaging lipids from the surface of the parasitpoid‘s eggs659647--
additional information?-Homo sapiens-the enzyme plays an essential role in breast cancer cells in alleviating oxidative stress generated from polyunsaturated fatty acid metabolism659398--
additional information?-Mesocricetus auratus-tyrosine phosphorylation of the enzyme may represent an important event in the signaling cascade associated with capacitation that may impact the regulation of hyperactivation of sperm motility and/or mitochondrial function658251--
additional information?-Sus scrofa-PhGPx prevents NF-kappaB activation, oxLDL-induced proliferation and linoleic acid-induced apoptosis685440--
additional information?-Mus musculus-PHGPx-/- mice are embryonically lethal at gestation day 7.5. PHGPx+/- mice cells show decreased life span after exposure to irradiation and increased susceptibility to oxidative and genotoxic stress685440--

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
glutathioneHomo sapiens--673807, 698045 2D-image
glutathioneRattus norvegicus--674502, 697778 2D-image
glutathioneRaphanus sativus--676554 2D-image
glutathioneMomordica charantiaQ8W259-696173 2D-image
glutathioneMus musculus--696435 2D-image
glutathioneanimal--696970 2D-image
glutathioneBombus ignitusC3VVL8-697468 2D-image
glutathioneCyprinus carpio--697470 2D-image
glutathioneTaiwanofungus camphoratusB8K1J5-698037 2D-image
glutathioneOryza sativa--701033 2D-image
glutathioneSchistosoma mansoni--701138 2D-image
glutathioneBos taurus--701272 2D-image

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
SeSus scrofa-1 g-atom Se per mol protein; Se in selenol form394864
SeBos taurus, Canis lupus familiaris, Rattus norvegicus, Sus scrofa-enzyme contains a selenocysteine residue at the active site394867
SeSus scrofa--394870
SeHomo sapiens-10 selenocysteines per protein molecule394873
SeBos taurus--394876
SeRattus norvegicus--394877, 394880
SeHomo sapiens--394878
SeHomo sapiens-enzyme contains a selenocysteine residue at the active site394879
SeSchistosoma mansoni--394882
SeRhipicephalus microplusQ2XW19TGA-encoded selenocysteine at residue 46 and active site residues Gln82 and Trp135 that interact with the selenocysteine674008
seleniumHomo sapiens-selenoprotein658247
seleniumRattus norvegicus-selenoprotein658758
seleniumMomordica charantiaQ8W259-696173
seleniumMus musculus--696435
seleniumBombus ignitusC3VVL8-697468
seleniumCyprinus carpio--697470
seleniumHomo sapiens--698045
seleniumSchistosoma mansoni--701138
seleniumBos taurus--701272

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
alpha-tocopherolBos taurus-complete inhibition of glutathione oxidation394876 2D-image
deoxycholateSus scrofa--394865 2D-image
deoxycholateHomo sapiens-in reaction with cumene hydroperoxide and linoleic acid hydroperoxide394878 2D-image
iodoacetateSus scrofa--394864 2D-image
iodoacetateSchistosoma mansoni--394882 2D-image
iodoacetateHomo sapiens-2 mM, complete inhibition672372 2D-image
MercaptosuccinateHomo sapiens-0.1 mM673807 2D-image
unsaturated fatty acidsSus scrofa--394865-

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
17-beta-estradiolBos taurusQ9N2J2causes increase in GPx-4 activity673343 2D-image
deoxycholateHomo sapiens-activity is slightly enhanced, but is enhanced by 50% together with Triton X-100394873 2D-image
H2O2Oryza sativa--701033 2D-image
NaClOryza sativa--701033 2D-image
selenoprotein PHomo sapiens-2 nM, 3fold stimulation of activity after 24h673807-
Sodium seleniteHomo sapiens-100 nM, 3fold stimulation of activity after 24h673807 2D-image
Triton X-100Sus scrofa--394864, 394865 2D-image
Triton X-100Homo sapiens--394873 2D-image

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.00014-1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-L-3-phosphatidylcholineOryza sativa-cosubstrate: glutathione687471 2D-image
0.0362-1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-L-3-phosphatidylcholineOryza sativa-cosubstrate: thioredoxin687471 2D-image
0.0017-cumene hydroperoxideTrypanosoma cruzi-recombinant enzyme394875 2D-image
0.119-cumene hydroperoxideSolanum lycopersicum--658606 2D-image
608-cumene hydroperoxideSolanum lycopersicum--658606 2D-image
1.37-glutathioneBos taurus--394876 2D-image
0.0008656-H2O2Bombus ignitusC3VVL8apparent KM697468 2D-image
0.6383-H2O2Momordica charantiaQ8W259apparent KM696173 2D-image
0.799-H2O2Oryza sativa-cosubstrate: glutathione687471 2D-image
0.00074-L-alpha-phosphatidylcholine hydroperoxideTrypanosoma cruzi-recombinant enzyme394875-
0.00058-linoleic acid hydroperoxideTrypanosoma cruzi-recombinant enzyme394875-
0.0393-linoleic acid hydroperoxideSolanum lycopersicum--658606-
0.0827-linoleic acid hydroperoxideSolanum lycopersicum--658606-
0.0121-phosphatidylcholine dilinoleoyl hydroperoxideSolanum lycopersicum--658606-
0.0249-phosphatidylcholine dilinoleoyl hydroperoxideSolanum lycopersicum--658606-
0.0002353-phosphatidylcholine hydroperoxideBombus ignitusC3VVL8apparent KM697468 2D-image
0.01113-phosphatidylcholine hydroperoxideMomordica charantiaQ8W259apparent KM696173 2D-image
0.011-phospholipid hydroperoxideBos taurus--394876-
0.0056-tert-butyl hydroperoxideTrypanosoma cruzi-recombinant enzyme394875 2D-image
0.0953-tert-butyl hydroperoxideSolanum lycopersicum--658606 2D-image
0.128-tert-butyl hydroperoxideSolanum lycopersicum--658606 2D-image
4.344-tert-butyl hydroperoxideOryza sativa-cosubstrate: glutathione687471 2D-image
2.932-tert-butyl-hydroperoxideMomordica charantiaQ8W259apparent KM696173 2D-image

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
91-(beta-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-gamma-palmitoyl)-L-alpha-phosphatidylcholineHomo sapiens--394878 2D-image
additional information-additional informationHomo sapiens-mutant compared to wild-type enzyme394879-

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.019-alpha-tocopherolBos taurus--394876 2D-image

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
0.0038-Homo sapiens-crude platelet homogenate672372
0.0048-Homo sapiens-cytosolic fraction672372
0.006-Homo sapiens-mitochondrial fraction672372
0.0062-Rattus norvegicus--394867
0.009-Homo sapiens--394878
0.0096-Homo sapiens-membrane fraction672372
0.032-Schistosoma mansoni--394882
0.04-Bos taurus-low-PHGPx group701272
0.051-Rattus norvegicus-enzyme from tissue lysate, using L-alpha-phosphatidylcholine hydroperoxide as peroxide substrate, at 37°C701060
0.0539-Bos taurus-low-PHGPx, Chianina701272
0.056-Bos taurus-low-PHGPx, Marchigiana701272
0.0746-Bos taurus-low-PHGPx, Romagnola701272
0.13-Bos taurus-high-PHGPx group701272
0.2242-Bos taurus-high-PHGPx, Chianina701272
0.2447-Bos taurus-high-PHGPx, Romagnola701272
0.2453-Bos taurus-high-PHGPx, Marchigiana701272
0.3-Rattus norvegicusP36970in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM KKSQCCQQKT as substrate674502
0.4-Rattus norvegicusP36970in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM KPPCCPPK as substrate674502
0.9-Sus scrofa-substrate tert-butyl hydroperoxide394868
2.03-Homo sapiens-addition of Triton X-100 and deoxycholate394873
2.2-Sus scrofa-substrate phosphatidylcholine394868
3.8-Sus scrofa-substrate cumene hydroperoxide394868
7-Bos taurus-purified enzyme394876
13.6-Rattus norvegicusP36970in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM PKSPCCPPKP as substrate674502
21.5-Rattus norvegicus-enzyme after 422fold purification, using L-alpha-phosphatidylcholine hydroperoxide as peroxide substrate, at 37°C701060
25.2-Rattus norvegicusP36970in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM PPKPCCPPKP as substrate674502
28.3-Rattus norvegicusP36970in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM PKPPCCPPKP as substrate674502
36-Rattus norvegicusP36970in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM QKSPCCPKSP as substrate674502
37.5-Rattus norvegicusP36970in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM QKPPCCPKSP as substrate674502
42-Rattus norvegicusP36970in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM PKSPCCPPKS as substrate674502
69-Rattus norvegicusP36970in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM PPPPCCPPPP as substrate674502
90-Schistosoma mansoni-partially purified enzyme394882
107-Sus scrofa-purified enzyme394868
160-Homo sapiens-purified enzyme, substrate linoleic acid hydroperoxide394878
160.2-Rattus norvegicusP36970in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM PPCCPP as substrate674502
190-Homo sapiens-purified enzyme, substrate cumene hydroperoxide394878
195.1-Sus scrofa-purified enzyme394864
210-Homo sapiens-purified enzyme, substrate H2O2394878
310.1-Sus scrofa-purified enzyme394867
336-Homo sapiens-purified enzyme, substrate (beta-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-gamma-palmitoyl)-L-alpha-phosphatidylcholine394878
109900-Rattus norvegicus-purified enzyme from cytosol394880
146300-Rattus norvegicus-purified enzyme from mitochondria394880
additional information-Rattus norvegicus-activity distribution in rat tissues394871
additional information-Rattus norvegicus-activity is age-dependent394877
additional information-Homo sapiens-mutant compared to wild-type enzyme394879
additional information-Rattus norvegicus-specific activity of cytosolic and mitochondrial enzymes with several hydroperoxide substrates and reducing agents394880
additional information-Sus scrofa-reduction of hydroperoxides of phosphatidylcholine and cholesteryllinolate associated to oxidized LDL and oxidized HDL394881

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
6.5-Bombus ignitusC3VVL8-697468
7.4-Bos taurus, Canis lupus familiaris, Rattus norvegicus, Sus scrofa-assay at394867
7.4-Homo sapiens-assay at394879
7.4-Sus scrofa-assay at394881
7.4-Homo sapiens-activity assay698045
7.4-Schistosoma mansoni-activity assay701138
7.5-Rattus norvegicus-assay at394880
7.5-Bombus ignitusC3VVL8activity assay697468
7.5-Bos taurus-activity assay701272
7.6-Sus scrofa-assay at394864
7.6-Homo sapiens-assay at394878
8-Homo sapiens-assay at394873
8-Saccharomyces cerevisiae-activity assay701118
8.5-Raphanus sativus--676554
9-Momordica charantiaQ8W259activity assay696173
9-Taiwanofungus camphoratusB8K1J5-698037
9.3-Oryza sativa--687471

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
411Bombus ignitusC3VVL8-697468
810.5Momordica charantiaQ8W259-696173
811Oryza sativa-pH 8.0: about 40% of maximal activity, pH 11: about 80% of maximal activity687471
89.5Raphanus sativus--676554

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
23-Taiwanofungus camphoratusB8K1J5activity assay at room temperature, ferrithiocyanate assay698037
23-Bos taurus-activity assay at room temperature701272
25-Schistosoma mansoni-activity assay701138
27-Oryza sativa--687471
27.5-Raphanus sativus--676554
30-Bombus ignitusC3VVL8-697468
37-Rattus norvegicus, Sus scrofa-assay at394867
37-Homo sapiens-assay at394873, 394878, 394879
37-Rattus norvegicus-assay at394880
37-Sus scrofa-assay at394881
40-Momordica charantiaQ8W259activity assay696173

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
1040Oryza sativa-10°C: 80% of maximal activity, 40°C: 60% of maximal activity687471
1045Raphanus sativus--676554
3050Momordica charantiaQ8W259-696173

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
8.5-Oryza sativa-isoelectric focusing electrophoresis687471

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
A2780/CP70 cellHomo sapiens-knockdown of GPx-4 by small interfering RNA technique in a human ovarian cancer cell line significantly enhances the cytotoxic effect of docosahexaenoic acid in a time- and concentration-dependent manner. This cytotoxic effect of docosahexaenoic acid is reversed by pretreatment with vitamin E, suggesting that the enhanced toxicity ofGPx-4 knockdown is due to changes in the ability of the cells to handle oxidative stress688924Manually annotated by BRENDA team
adrenal glandMus musculus--673845Manually annotated by BRENDA team
aortaHomo sapiens-transgenic mouse698045Manually annotated by BRENDA team
arteryMus musculus-smooth muscle cells688464Manually annotated by BRENDA team
blood plateletHomo sapiens-resting blood platelet672372Manually annotated by BRENDA team
boneMus musculus--673845Manually annotated by BRENDA team
bone marrowHomo sapiens--671327Manually annotated by BRENDA team
brainRattus norvegicus--394866, 394867, 394871Manually annotated by BRENDA team
brainBos taurus, Canis lupus familiaris, Sus scrofa--394867Manually annotated by BRENDA team
brainHomo sapiens--671327Manually annotated by BRENDA team
brainMus musculus--674370, 674598Manually annotated by BRENDA team
brainCyprinus carpio--697470Manually annotated by BRENDA team
breast cancer cellHomo sapiens--659398Manually annotated by BRENDA team
breast cancer cell lineHomo sapiens-COH-BR1 cells675048Manually annotated by BRENDA team
breast invasive ductal carcinomaHomo sapiens-PHGPx expression levels are downregulated in poorly differentiated (grade 3) breast invasive ductal carcinoma. PHGPx expression levels decrease gradually with tumor grade from grade 1 to grade 3. Downregulation of PHGPx in cases that showed p53 accumulation compared with cases without p53 immunostaining is observed. PHGPx is downregulated in cases without progesterone receptors immunostaining compared with cases with PR immunostaining686896Manually annotated by BRENDA team
C81-61 cellHomo sapiens-treatment with docosahexaenoic acid results in 95% decrease in GPx-4 level688924Manually annotated by BRENDA team
callusCitrus sinensis-ovular callus, salt-sensitive and adapted salt-tolerant cell lines394872Manually annotated by BRENDA team
cerebellar Purkinje cellMus musculus--688464Manually annotated by BRENDA team
cerebellumHomo sapiens--671327Manually annotated by BRENDA team
cerebellumMus musculus-white matter688464Manually annotated by BRENDA team
cerebellumCyprinus carpio--697470Manually annotated by BRENDA team
colonHomo sapiens--671327Manually annotated by BRENDA team
embryoMus musculus--696435Manually annotated by BRENDA team
endothelial cell lineHomo sapiens--673807Manually annotated by BRENDA team
epidermisBombus ignitusC3VVL8-697468Manually annotated by BRENDA team
epididymisMus musculus--688464Manually annotated by BRENDA team
erythrocyteHomo sapiens--672372Manually annotated by BRENDA team
fat bodyBombus ignitusC3VVL8extraction of genomic DNA697468Manually annotated by BRENDA team
fat padHomo sapiens--659398Manually annotated by BRENDA team
fibroblastMus musculus--674370Manually annotated by BRENDA team
fibrosarcoma cellMus musculus--674370Manually annotated by BRENDA team
flag leafOryza sativa--701033Manually annotated by BRENDA team
forestomachMus musculus-keratinized surface epithelium688464Manually annotated by BRENDA team
fruitbodyTaiwanofungus camphoratusB8K1J5-698037Manually annotated by BRENDA team
gut epitheliumMus musculus--673845Manually annotated by BRENDA team
heartSus scrofa--394864, 394865, 394867, 394868, 394869, 394870, 394881Manually annotated by BRENDA team
heartRattus norvegicus--394867, 394871Manually annotated by BRENDA team
heartBos taurus--394867Manually annotated by BRENDA team
heartHomo sapiens--671327Manually annotated by BRENDA team
heartMus musculus--673845, 674370, 674598, 686888Manually annotated by BRENDA team
heartMus musculus-parenchym688464Manually annotated by BRENDA team
heartCyprinus carpio--697470Manually annotated by BRENDA team
hemolymphBombus ignitusC3VVL8-697468Manually annotated by BRENDA team
HL-60 cellHomo sapiens--671713Manually annotated by BRENDA team
HL-60 cellHomo sapiens-treatment with docosahexaenoic acid results in 60% decrease in GPx-4 level688924Manually annotated by BRENDA team
HT-29 cellHomo sapiens-treatment with docosahexaenoic acid results in 90% decrease in GPx-4 level688924Manually annotated by BRENDA team
ileumMus musculus--688464Manually annotated by BRENDA team
integumentSchistosoma mansoni--701138Manually annotated by BRENDA team
intestineMus musculus--674370Manually annotated by BRENDA team
intestineMus musculus-Paneth cells688464Manually annotated by BRENDA team
jejunumMus musculus--688464Manually annotated by BRENDA team
kidneyRattus norvegicus--394867, 394871Manually annotated by BRENDA team
kidneyBos taurus, Canis lupus familiaris, Sus scrofa--394867Manually annotated by BRENDA team
kidneyHomo sapiens--659398, 671327Manually annotated by BRENDA team
kidneyMus musculus--673845, 674370Manually annotated by BRENDA team
kidneyMus musculus-; tubular epithelium688464Manually annotated by BRENDA team
kidneyCyprinus carpio--697470Manually annotated by BRENDA team
L929 cellMus musculus--674370Manually annotated by BRENDA team
leafRaphanus sativus--676554Manually annotated by BRENDA team
leafOryza sativa--701033Manually annotated by BRENDA team
leukemia cellRattus norvegicus-basophil leucemia cell line S1 wild-type cell line and (RBL)2H3 cell line overexpressing mitochondrial phospholipid hydroperoxide glutathione peroxidase394883Manually annotated by BRENDA team
leukocyteHomo sapiens--671713Manually annotated by BRENDA team
leukocyteRattus norvegicus--671833Manually annotated by BRENDA team
liverSus scrofa--394867, 394868Manually annotated by BRENDA team
liverRattus norvegicus--394867, 394871Manually annotated by BRENDA team
liverBos taurus, Canis lupus familiaris--394867Manually annotated by BRENDA team
liverHomo sapiens--394878, 659398, 671327Manually annotated by BRENDA team
liverMus musculus--673845, 674370Manually annotated by BRENDA team
liverMus musculus-parenchym688464Manually annotated by BRENDA team
liverCyprinus carpio--697470Manually annotated by BRENDA team
lungRattus norvegicus--394867, 394871Manually annotated by BRENDA team
lungHomo sapiens--659398, 671327Manually annotated by BRENDA team
lungMus musculus--673845, 674370Manually annotated by BRENDA team
lungMus musculus-parenchym688464Manually annotated by BRENDA team
mammary glandHomo sapiens-expression level may vary during mammary gland development659398Manually annotated by BRENDA team
MCF-7 cellHomo sapiens-treatment with docosahexaenoic acid results in 90% decrease in GPx-4 level688924Manually annotated by BRENDA team
MEF cellMus musculus--696435Manually annotated by BRENDA team
metacercariaClonorchis sinensisA0SWV9, A0SWW0, A0SWW1, A0SWW2; 687186Manually annotated by BRENDA team
metacercariumClonorchis sinensisA0SWV9, A0SWW0, A0SWW1, A0SWW2; 687186Manually annotated by BRENDA team
midbrainCyprinus carpio--697470Manually annotated by BRENDA team
midgutBombus ignitusC3VVL8-697468Manually annotated by BRENDA team
MM1.R cellHomo sapiens-treatment with docosahexaenoic acid results in 60% decrease in GPx-4 level688924Manually annotated by BRENDA team
MM1.S cellHomo sapiens-treatment with docosahexaenoic acid results in 21% decrease in GPx-4 level688924Manually annotated by BRENDA team
muscleRattus norvegicus--394867, 394871Manually annotated by BRENDA team
muscleBombus ignitusC3VVL8-697468Manually annotated by BRENDA team
muscleCyprinus carpio--697470Manually annotated by BRENDA team
neurohypophysisMus musculus-pituicytes688464Manually annotated by BRENDA team
neutrophilHomo sapiens--671713Manually annotated by BRENDA team
neutrophilRattus norvegicus--671833Manually annotated by BRENDA team
olfactory epitheliumMus musculus--673845Manually annotated by BRENDA team
olfactory lobeCyprinus carpio--697470Manually annotated by BRENDA team
ovaryMus musculus--674370Manually annotated by BRENDA team
oviduct epitheliumBos taurusQ9N2J2-673343Manually annotated by BRENDA team
PANC-1 cellHomo sapiens-treatment with docosahexaenoic acid results in 95% decrease in GPx-4 level688924Manually annotated by BRENDA team
pancreasMus musculus--673845Manually annotated by BRENDA team
pancreasMus musculus-exocrine portion688464Manually annotated by BRENDA team
pancreatic cancer cellHomo sapiens--673931Manually annotated by BRENDA team
pituicyteMus musculus--688464Manually annotated by BRENDA team
placentaHomo sapiens--671327Manually annotated by BRENDA team
plasmaHomo sapiens-extracellular localisation394873Manually annotated by BRENDA team
prostate glandHomo sapiens--671327Manually annotated by BRENDA team
RAJI cellHomo sapiens-treatment with docosahexaenoic acid results in 85% decrease in GPx-4 level688924Manually annotated by BRENDA team
RBL-2H3 cellRattus norvegicus-PHGPx-overexpressed cell697778Manually annotated by BRENDA team
retinaBos taurus--394876Manually annotated by BRENDA team
RINm5F cellRattus norvegicus-100 nM 8(S/R)-hydroxy-11(S),12S-trans-epoxyeicosa-5Z,9E,14Z-trienoic acid upregulates phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA and protein expressions. Under persistent oxidative stress the formation of 8(S/R)-hydroxy-11(S),12S-trans-epoxyeicosa-5Z,9E,14Z-trienoic acid and the 8(S/R)-hydroxy-11(S),12S-trans-epoxyeicosa-5Z,9E,14Z-trienoic acid-induced upregulation of PHGPx constitute a compensatory defense response to protect the vitality and functionality of the cell689838Manually annotated by BRENDA team
seedlingOryza sativa--701033Manually annotated by BRENDA team
shootOryza sativa--701033Manually annotated by BRENDA team
skeletal muscleHomo sapiens--671327Manually annotated by BRENDA team
skinMus musculus--673845Manually annotated by BRENDA team
small intestineHomo sapiens--671327Manually annotated by BRENDA team
smooth muscle cellMus musculus-of arteries688464Manually annotated by BRENDA team
spermHomo sapiens-enzyme is transformed to an oxidatively inactivated protein in mature sperm, where it is a major constituent of the mitochondrial capsule in the midpiece658247Manually annotated by BRENDA team
spermMesocricetus auratus-mitochondrial capsule658251Manually annotated by BRENDA team
spermMus musculus--675965Manually annotated by BRENDA team
spermatidHomo sapiens-enzyme is expressed as active peroxidase658247Manually annotated by BRENDA team
spermatocyteMus musculusO70325PHGPx expression is tightly regulated in pachytene spermatocytes, with any spatial-temporal increase in PHGPx expression resulting in damage to spermatogenesis and eventual loss of haploid cells686405Manually annotated by BRENDA team
spermatozoonRattus norvegicus--394867, 658758, 674502Manually annotated by BRENDA team
spermatozoonBos taurus--394867, 701272Manually annotated by BRENDA team
spermatozoonRattus norvegicus-epididymal, hormone regulated appearance394877Manually annotated by BRENDA team
spermatozoonHomo sapiens-activity does not differ between normo- and hypomotile human sperm samples658926Manually annotated by BRENDA team
spermatozoonHomo sapiens--671327Manually annotated by BRENDA team
spermatozoonMus musculus--696435Manually annotated by BRENDA team
spinal cordHomo sapiens--671327Manually annotated by BRENDA team
spleenHomo sapiens--671327Manually annotated by BRENDA team
spleenMus musculus--673845, 674370Manually annotated by BRENDA team
spleenMus musculus-red pulp688464Manually annotated by BRENDA team
sternal cartilageMus musculus--673845Manually annotated by BRENDA team
stomachHomo sapiens--671327Manually annotated by BRENDA team
stomachMus musculus--688464Manually annotated by BRENDA team
submandibular glandMus musculus--673845Manually annotated by BRENDA team
submucosal glandMus musculus--688464Manually annotated by BRENDA team
telencephalonMus musculus--688464Manually annotated by BRENDA team
testisRattus norvegicus--394867, 673176, 701060Manually annotated by BRENDA team
testisRattus norvegicus-hormone regulated appearance394877Manually annotated by BRENDA team
testisRattus norvegicus-strongly linked to mitochondria of cells undergoing differentiation to spermatozoa, under gonadotropin control394880Manually annotated by BRENDA team
testisHomo sapiens--659398, 671327Manually annotated by BRENDA team
testisMus musculus--673845, 674370, 696435Manually annotated by BRENDA team
testisMus musculus-PHGPx mRNA is highly expressed in spermiogenic cells and Leydig cell688464Manually annotated by BRENDA team
testisRattus norvegicus-treatment with testosterone slightly decreases PHGPx mRNA levels in testes by the reverse transcription-polymerase chain reaction. Anti-androgenic compounds (flutamide, ketoconazole, and diethylhexyl phthalate) and estrogenic compounds (nonylphenol, octylphenol, and diethylstilbestrol) significantly upregulate PHGPx mRNA in the testes. Endocrine disrupting chemicals might have a detrimental effect on spermatogenesis via abnormal enhancement of PHGPx expression in testes688724Manually annotated by BRENDA team
testisBos taurus--701272Manually annotated by BRENDA team
thymusMus musculus--673845Manually annotated by BRENDA team
thyroid glandHomo sapiens--671327Manually annotated by BRENDA team
thyroid glandMus musculus-parafollicular cells and follicular basement membrane688464Manually annotated by BRENDA team
tongueMus musculus--673845Manually annotated by BRENDA team
tracheaHomo sapiens--671327Manually annotated by BRENDA team
uterusHomo sapiens--671327Manually annotated by BRENDA team
uterusMus musculus--674370Manually annotated by BRENDA team
white adipose tissueHomo sapiens--659398Manually annotated by BRENDA team
whole bodyBombus ignitusC3VVL8cDNA library697468Manually annotated by BRENDA team

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
cytoplasmHomo sapiens--5737659398Manually annotated by BRENDA team
cytosolRattus norvegicus--5829394867, 394877, 394880, 673176, 685440Manually annotated by BRENDA team
cytosolSus scrofa--5829394867Manually annotated by BRENDA team
cytosolHomo sapiens--5829394878, 672372, 673807, 685185Manually annotated by BRENDA team
cytosolSchistosoma mansoni--5829394882Manually annotated by BRENDA team
cytosolMus musculus--5829673845, 674370, 674598, 696435Manually annotated by BRENDA team
cytosolRaphanus sativus--5829676554Manually annotated by BRENDA team
membraneHomo sapiens--16020672372Manually annotated by BRENDA team
membraneBos taurusQ9N2J2-16020673343Manually annotated by BRENDA team
microsomeRattus norvegicus---394867, 394871, 394877Manually annotated by BRENDA team
microsomeBos taurus, Canis lupus familiaris, Sus scrofa---394867Manually annotated by BRENDA team
mitochondrionRattus norvegicus-inner membrane5739394866Manually annotated by BRENDA team
mitochondrionRattus norvegicus--5739394880, 394883, 673176, 674502, 697778Manually annotated by BRENDA team
mitochondrionMesocricetus auratus--5739658251Manually annotated by BRENDA team
mitochondrionHomo sapiens--5739672372Manually annotated by BRENDA team
mitochondrionHydra vulgarisQ072C7-5739673837Manually annotated by BRENDA team
mitochondrionMus musculus-only in testicle5739673845Manually annotated by BRENDA team
mitochondrionHomo sapiens-L-form of the enzyme5739673931Manually annotated by BRENDA team
mitochondrionMus musculus--5739674370, 674598, 696435Manually annotated by BRENDA team
mitochondrionRaphanus sativus--5739676554Manually annotated by BRENDA team
nucleusRattus norvegicus--5634673176Manually annotated by BRENDA team
nucleusMus musculus-only in testicle5634673845Manually annotated by BRENDA team
nucleusMus musculus--5634674370, 674598, 675965, 696435Manually annotated by BRENDA team
particle-boundBos taurus-high-salt extract from retina-394876Manually annotated by BRENDA team
mitochondrionMus musculusO70325; transgenic mice in which PHGPx is overexpressed solely in the mitochondrion. Mitochondria-specific GPx4 overexpression protects cardiac contractile function and preserves electron transport chain complex activities following ischemia/reperfusion5739686888Manually annotated by BRENDA team
additional informationSus scrofa-interfacial character of the enzyme-394864Manually annotated by BRENDA team
additional informationHomo sapiens-extracellular localisation-394873Manually annotated by BRENDA team
additional informationMus musculusO70325not detected in the nucleus-686888Manually annotated by BRENDA team

PDBSCOPCATHORGANISM
2gs3, downloadSCOP (2gs3)CATH (2gs3)Homo sapiens
2obi, downloadSCOP (2obi)CATH (2obi)Homo sapiens

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
6000-Bos taurus-below, retina enzyme, gel filtration394876
16100-Homo sapiens-gel filtration394878
18000-Taiwanofungus camphoratusB8K1J5His6-tagged fusion protein, determined by SDS-PAGE698037
18300-Rattus norvegicus-recombinant enzyme, glutathione-S-transferase-tag cut off, SDS-PAGE394877
18500-Raphanus sativus-cytosolic enzyme form, SDS-PAGE676554
19000-Bombus ignitusC3VVL8determined by SDS-PAGE697468
19400-Schistosoma mansoni-determined by gel filtration701138
20000-Bos taurus, Canis lupus familiaris, Rattus norvegicus, Sus scrofa--394867
20000-Sus scrofa-gel filtration394868
20000-Schistosoma mansoni-gel filtration394882
20000-Rattus norvegicus-mitochondrial and cytosolic enzyme form, SDS-PAGE673176
20000-Mus musculus--696435
20000-Rattus norvegicus-SDS-PAGE701060
21000-Homo sapiens-20 to 22 kDa698045
21480-Hydra vulgarisQ072C7calculated from sequence of cDNA673837
21500-Raphanus sativus-mitochondrial enzyme form, SDS-PAGE676554
22000-Rattus norvegicus-gel filtration394880
22500-Momordica charantiaQ8W259His6-McPHGPx fusion protein, determined by SDS-PAGE696173
23000-Sus scrofa-gel filtration394864
34000-Rattus norvegicus-nucleic enzyme form, SDS-PAGE673176
69000-Homo sapiens-native PAGE394873

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
?Rattus norvegicus-x * 20000, cytosolic enzyme form, SDS-PAGE; x * 25900, truncated form of nuclear enzyme, lacking the basic nuclear localization signal, SDS-PAGE658758
?Oryza sativa-x * 21000, recombinant enzyme containing a six-histidine tag at its N-terminus, SDS-PAGE687471
monomerSus scrofa-1 * 20000, SDS-PAGE; 1 * 23000, SDS-PAGE394864
monomerSus scrofa-1 * 20000, SDS-PAGE394867, 394868
monomerBos taurus, Canis lupus familiaris, Rattus norvegicus--394867
monomerHomo sapiens-1 * 66000, SDS-PAGE394873
monomerBos taurus-1 * 6000, about, retina enzyme, SDS-PAGE394876
monomerRattus norvegicus-1 * 18300-20000, recombinant and wild-type, SDS-PAGE394877
monomerRattus norvegicus-1 * 22000, SDS-PAGE394880
monomerSchistosoma mansoni-1 * 20000, SDS-PAGE394882
monomerHomo sapiens-1 * 20000, non-mitochondrial S-form of the enzyme; 1 * 23000, mitochondrial L-form of the enzyme672372
monomerMomordica charantiaQ8W259-696173
monomerMus musculus--696435
monomerCyprinus carpio--697470
monomerTaiwanofungus camphoratusB8K1J5-698037
monomerHomo sapiens--698045
monomerSchistosoma mansoni--701138
additional informationRattus norvegicus-cytosolic enzyme shows also a minor component in SDS-PAGE at higher molecular weight, which is not further characterized394880
additional informationHomo sapiensP36969like the wild-type enzyme, the U46C mutant exhibits a strong tendency toward protein polymerization, which was prevented by reductants685185

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
phosphoproteinMesocricetus auratus-tyrosine phosphorylation generates multiple isoforms of the mitochondrial capsule protein during sperm capacitation658251

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
sparse matrix crystallization method, crystal structure of the catalytically active U46C mutant of human GPx4 to 1.55 A resolutionHomo sapiensP36969685185
the crystal structure is solved to a resolution of 2.0 ASaccharomyces cerevisiae-701118
the crystal structures of the Sec43Cys and Sec43Ser mutants are solved at resolutions of 1.0 A and 1.7 A, respectivelySchistosoma mansoni-701138

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
40-Bombus ignitusC3VVL8thermal stability shows that the activity is significantly decreased when the temperature is higher than 40°C697468
65-Sus scrofa-complete loss of activity after 5 min394868
additional information-Citrus sinensis-heat stress at 37°C leads to increase in RNA transcript level in salt-sensitive cell line and slightly also in salt-tolerant cell line, exposure to 4°C had no effect394872

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
presence of thiol, e.g. 2-mercaptoethanol, during purification is necessary for stabilizationRattus norvegicus-394880
alpha-tocopherol stabilizes triple mutant against H2O2 and unsaturated linolenateSaccharomyces cerevisiae-394874

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
ureaOryza sativa-with the increase of urea concentration, the residual activity of OsPHGPx decreases correspondingly. When the urea concentration is above 5.0 mol/l, there is no residual activity. The unfolding process comprises of three zones: the native base-line zone between 0 and 2. 5 mol/l urea, the transition zone between 2.5 and 5.5 mol/l urea, and the denatured base-line zone above 5.5 mol/l urea. The transition zone has a midpoint at about 4.0 mol/l urea686071

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-40°C, about 30% loss of activity during 1 freeze-thaw-cycleHomo sapiens-394878
4°C, loss of 10% activity in 1 weekHomo sapiens-394878
-20°C, 10% glycerol, stable for several monthsSus scrofa-394867

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
using a HisTrap columnBombus ignitusC3VVL8697468
-Bos taurus-394876
-Drosophila melanogaster-659647
-Homo sapiens-394873, 394878, 672372
large-scale, wild-type and mutant SeC46C from baculovirus/insect cell expression system and mutant SeC46C from expression in Escherichia coli as His-tagged fusion proteinHomo sapiens-394879
by nickel affinity chromatographyMomordica charantiaQ8W259696173
-Oryza sativa-687471
recombinant enzymeOryza sativa-686071
Percoll step gradient and nickel affinity chromatographyRaphanus sativus-676554
ammonium sulfate precipitation, DEAE-Sepharose column chromatography, Sephadex G-50 gel filtration, and HiTrap SP column chromatographyRattus norvegicus-701060
from cytosol and mitochondriaRattus norvegicus-394880
partiallyRattus norvegicus-394866
partially from testis and to homogenity from sperm as recombinant enzyme expressed in Escherichia coli and as wild-type enzymeRattus norvegicus-394877
on a Ni-NTA column, further purified by gel filtrationSaccharomyces cerevisiae-701118
wild-type and mutant proteinsSaccharomyces cerevisiae-394874
partiallySchistosoma mansoni-394882
Sec43Cys is purified on a GSH-Sepharose column, Sec43Ser is purified by ionic exchange chromatography, the GST-tags are cleaved with bovine thrombinSchistosoma mansoni-701138
-Sus scrofa-394864, 394867, 394868, 394869
by Ni2+-nitrilotriacetic acid SepharoseTaiwanofungus camphoratusB8K1J5698037
recombinant enzyme from Escherichia coliTrypanosoma cruzi-394875
-Venturia canescens-659647

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
the baculovirus expression vector system, using the Autographa californica nucleopolyhedrovirus and the Sf9 insect cell line, is used to produce recombinant Bi-PHGPx proteins, the cDNA fragment containing the full-length open reading frame is inserted into the transfer vector pBAC1Bombus ignitusC3VVL8697468
expression in Escherichia coli; expression in Escherichia coli; expression in Escherichia coli; expression in Escherichia coliClonorchis sinensisA0SWV9, A0SWW0, A0SWW1, A0SWW2687186
for sequencingCyprinus carpio-697470
expression in Escherichia coliDrosophila melanogaster-659647
expressed in MIA PaCa-2 and AsPC-1 human pancreatic cancer cellsHomo sapiens-673931
expressed in tumor cell transfectant clone 7G4Homo sapiens-675048
expression of mutant enzyme U46C in Escherichia coliHomo sapiensP36969685185
expression of wild-type enzyme and SeC46C mutant in baculovirus/insect cell system and expression of mutant SeC46C as His-tagged fusion protein in Escherichia coliHomo sapiens-394879
transgenic mice overexpressing human GPx4 are generatedHomo sapiens-698045
into the vector pET-28a+ for expression in Escherichia coli BL21DE3 cells, into the vector YEpGAP112 for a functional complementation test in yeastMomordica charantiaQ8W259696173
production of a transgenic mouse line overexpressing mPHGPx in the testis during the prophase of the first meiotic division, when the endogenous mPHGPx level is markedly lower than in the postmeiotic phase. Such mPHGPx overexpression is associated with male germ apoptosis, seminiferous tubule disorganization and reduced fertilityMus musculusO70325686405
expression in Escherichia coliOryza sativa-686071
the entire encoding region for Oryza sativa PHGPx is expressed in Escherichia coli M15Oryza sativa-687471
expressed in Escherichia coliRaphanus sativus-676554
expression vector encoding mitochondrial enzyme for overexpression in (RBL)2H3 cell lineRattus norvegicus-394883
spermatozoa enzyme, expression in Escherichia coli as glutathione-S-transferase fusion proteinRattus norvegicus-394877
the open reading frame of Hyr1/YIR037W is cloned into a pET28a-derived vector for expression in Escherichia coli Rosetta DE3 cellsSaccharomyces cerevisiae-701118
the triple deletion mutant gpx1delta/gpx2delta/gpx3delta is not growing with medium containing unsaturated linolenate; wild-type enzyme gpx1, gpx2, gpx3 and mutants, expression in Escherichia coliSaccharomyces cerevisiae-394874
the codon optimized gene is cloned into the vector pGex4T-1 for expression in Escherichia coli BL21DE3 cellsSchistosoma mansoni-701138
expression in Escherichia coliSolanum lycopersicum-658606
into the vector pYEX-S1 for transformation into Saccharomyces cerevisiae cellsTaiwanofungus camphoratusB8K1J5698037
His-tagged protein termed TcGPX1, expression in Escherichia coliTrypanosoma cruzi-394875
expression in Escherichia coliVenturia canescens-659647

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
Bi-PHGPx transcripts are up-regulated by stresses, such as wounding, H2O2 exposure, external temperature shock, and starvationBombus ignitusC3VVL8697468
PHGPx expression is up-regulated in spermatozoa by unknown mechanismsBos taurus-701272
10 mg/l Cd2+ down-regulates gpx4b in liver and olfactory lobe tissues; in the liver of the carp exposed to 7°C temperature drop, the gpx4a gene is down-regulated as early as 1 h after cold shock to 75%Cyprinus carpio-697470
in liver direct exposure to low temperature increases the transcription of gpx4b by 2.5foldCyprinus carpio-697470
expression in rice seedlings can be markedly induced by H2O2 and NaClOryza sativa-701033

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
Sec43CysSchistosoma mansoni-mutation of the selenium cysteine in the active site701138
Sec43SerSchistosoma mansoni-mutation of the selenium cysteine in the active site701138
SeC46CHomo sapiens-expression of mutant in Escherichia coli as His-tagged fusion protein and in baculovirus/insect cell system, site directed mutagenesis to avoid recognition problems of selenocysteine encoded by TGA stop codon in the expression systems, mutant has reduced specific acitvity394879
additional informationRattus norvegicus-(RBL)2H3 cell line stably overexpressing mitochondrial phospholipid hydroperoxide glutathione peroxidase from transfected expression plasmid394883
C82SSaccharomyces cerevisiae-in the presence of thioredixin system, wild-type Hyr1 can consume H2O2 rapidly, while the C82S mutant totally abolish the activity, indicating the important role of Cys82 in Trx2 specifity701118
additional informationSaccharomyces cerevisiae-deletion mutants of gpx1delta, gpx2delta and gpx3delta showing diminished enzyme activity, triple mutant gpx1delta/gpx2delta/gpx3delta has almost no remaining activity394874

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
analysisHomo sapiens-because the content of enzyme, irrespective of the cause of alteration, is correlated with fertility-related parameters, PHGPx can be considered a predictive measure for fertilization capacity658247
medicineHomo sapiens-tumor growth inhibitor673931
medicineHomo sapiens-PHGPx downregulation could be related with a poorer prognosis in breast invasive ductal carcinoma686896
medicineHomo sapiens-overexpression of GPx4 inhibits the development of atherosclerosis by decreasing lipid peroxidation and inhibiting the sensitivity of vascular cells to oxidized lipids698045
medicineRattus norvegicus-PHGPx is useful as a biomarker to screen for detrimental effects of exogenous endocrine disrupting chemicals in testes688724
additional informationanimal-comparative analysis of invertebrate GPx genes provides information evidence to support the modular pathways of GPx evolution, which have been accompanied with sporadic expansion-deletion and exon-intron remodeling, the study would be beneficial to get detailed insights into the complex GPx evolution, and to understand the molecular basis of the specialized physiological implications of the antioxidant system in their respective organisms696970
additional informationBos taurus-an assay for sperm PHGPx activity emerges as a unique tool to evaluate semen quality for sire selection701272

DISEASETITLE OF PUBLICATIONLINK TO PUBMED
AdenocarcinomaTissue microarray assessment of selenoprotein P expression in gastric adenocarcinoma. PubMed
AdenomaInverse mRNA expression of the selenocysteine-containing proteins GI-GPx and SeP in colorectal adenomas compared with adjacent normal mucosa. PubMed
Alzheimer DiseaseAssociation of selenoprotein p with Alzheimer's pathology in human cortex. PubMed
Alzheimer DiseaseDelineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease. PubMed
Alzheimer DiseaseRole of selenoprotein P in Alzheimer's disease. PubMed
AtherosclerosisOverexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFkappaB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells. PubMed
AtherosclerosisSerum selenoprotein p levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis. PubMed
AtherosclerosisSuppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. PubMed
Barrett EsophagusGenetic Variation in GPX1 Is Associated with GPX1 Activity in a Comprehensive Analysis of Genetic Variations in Selenoenzyme Genes and Their Activity and Oxidative Stress in Humans. PubMed
Brain InjuriesRole for glutathione peroxidase-4 in brain development and neuronal apoptosis: specific induction of enzyme expression in reactive astrocytes following brain injury. PubMed
Breast NeoplasmsIdentification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. PubMed
Breast NeoplasmsImpaired expression of glutathione peroxidase-4 gene in peripheral blood mononuclear cells: A biomarker of increased breast cancer risk. PubMed
Breast NeoplasmsPhospholipid hydroperoxide glutathione peroxidase induces a delay in G1 of the cell cycle. PubMed
Breast NeoplasmsPhospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy. PubMed
Burkitt LymphomaCloning of phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an anti-apoptotic and growth promoting gene of Burkitt lymphoma cells. PubMed
CarcinomaInverse regulation of lipid-peroxidizing and hydroperoxyl lipid-reducing enzymes by interleukins 4 and 13. PubMed
CarcinomaPHGPx overexpression induces an increase in COX-2 activity in colon carcinoma cells. PubMed
Carcinoma, DuctalPhospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma. PubMed
Carcinoma, HepatocellularDirect separation of hydroperoxy- and hydroxy-phosphatidylcholine derivatives: application to the assay of phospholipid hydroperoxide glutathione peroxidase. PubMed
Carcinoma, HepatocellularHepatitis B virus X protein induces TNF-alpha expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2. PubMed
Carcinoma, HepatocellularMolecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression. PubMed
Carcinoma, HepatocellularmRNA stability and selenocysteine insertion sequence efficiency rank gastrointestinal glutathione peroxidase high in the hierarchy of selenoproteins. PubMed
Carcinoma, HepatocellularNano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice. PubMed
Carcinoma, HepatocellularPolysome distribution of phospholipid hydroperoxide glutathione peroxidase mRNA: evidence for a block in elongation at the UGA/selenocysteine codon. PubMed
Carcinoma, HepatocellularPossible involvement of reactive oxygen species in D-galactosamine-induced sensitization against tumor necrosis factor-alpha-induced hepatocyte apoptosis. PubMed
Carcinoma, HepatocellularSelective control of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNA stability by selenium supply. PubMed
Carcinoma, HepatocellularSelenoprotein P mRNA expression in human hepatic tissues. PubMed
Carcinoma, HepatocellularStimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor. PubMed
Carcinoma, Squamous CellDepletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells. PubMed
Carcinoma, Squamous CellInhibition of arachidonate metabolism in human epidermoid carcinoma a431 cells overexpressing phospholipid hydroperoxide glutathione peroxidase. PubMed
Carcinoma, Squamous CellInvolvement of reactive oxygen species in arsenite-induced downregulation of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells. PubMed
Carcinoma, Squamous CellRegulation of cyclooxygenase and 12-lipoxygenase catalysis by phospholipid hydroperoxide glutathione peroxidase in A431 cells. PubMed
Carcinoma, Squamous CellThe CCAAT-box binding factor NF-Y is required for the expression of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells. PubMed
CardiomegalyCytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice. PubMed
CataractEffect of plant-based feed ingredients on osmoregulation in the Atlantic salmon lens. PubMed
CholangiocarcinomaVitellocyte-specific expression of phospholipid hydroperoxide glutathione peroxidases in Clonorchis sinensis. PubMed
Colonic NeoplasmsExpression profiling and genetic alterations of the selenoproteins GI-GPx and SePP in colorectal carcinogenesis. PubMed
Colorectal NeoplasmsAberrant expression of selenoproteins in the progression of colorectal cancer. PubMed
Colorectal NeoplasmsEvidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. PubMed
Colorectal NeoplasmsGlutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells. PubMed
Colorectal NeoplasmsProinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction. PubMed
Diabetes ComplicationsTestis glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase activities in aminoguanidine-treated diabetic rats. PubMed
Esophageal NeoplasmsGenetic Variation in GPX1 Is Associated with GPX1 Activity in a Comprehensive Analysis of Genetic Variations in Selenoenzyme Genes and Their Activity and Oxidative Stress in Humans. PubMed
FowlpoxSECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes. PubMed
Hepatitis BHepatitis B virus X protein induces TNF-alpha expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2. PubMed
HyperglycemiaAttenuation of hepatic expression and secretion of selenoprotein P by metformin. PubMed
HypersensitivityReverse genetic analysis of the glutathione metabolic pathway suggests a novel role of PHGPX and URE2 genes in aluminum resistance in Saccharomyces cerevisiae. PubMed
HypersensitivitySelenoperoxidase-mediated cytoprotection against the damaging effects of tert-butyl hydroperoxide on leukemia cells. PubMed
HypertensionThe C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension. PubMed
Idiopathic Pulmonary FibrosisInvolvement of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis. PubMed
InfectionAlternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P. PubMed
InfectionSuppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase. PubMed
InfertilityEssential role of the apolipoprotein E receptor-2 in sperm development. PubMed
InfertilityGenetic variations of gpx-4 and male infertility in humans. PubMed
InfertilityHepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice. PubMed
InfertilityMolecular genetics of human male infertility: from genes to new therapeutic perspectives. PubMed
Infertility[Biological significance of lipid hydroperoxide and its reducing enzyme, phospholipid hydroperoxide glutathione peroxidase, in mammalian cells] PubMed
Infertility, MaleGenetic variations of gpx-4 and male infertility in humans. PubMed
Infertility, MaleMale fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase. PubMed
Infertility, MaleMitochondrial glutathione peroxidase 4 disruption causes male infertility. PubMed
Infertility, MaleNew Strategy of Functional Analysis of PHGPx Knockout Mice Model Using Transgenic Rescue Method and Cre-LoxP System. PubMed
Infertility, MaleOral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels. PubMed
Infertility, MaleTestosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation. PubMed
Infertility, Male[Association between single nucleotide polymorphisms of 5'-untranslated region of GPx4 gene and male infertility]. PubMed
Insulin ResistanceA liver-derived secretory protein, selenoprotein P, causes insulin resistance. PubMed
Insulin ResistanceInverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes. PubMed
Insulin ResistanceS-Adenosylmethionine Dependent Protein Methylation is Required for Expression of Selenoprotein P and Gluconeogenic Enzymes in Human Hepatocytes. PubMed
Insulin ResistanceSerum selenoprotein p levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis. PubMed
InsulinomaBiosynthesis of hepoxilins: evidence for the presence of a hepoxilin synthase activity in rat insulinoma cells. PubMed
Kashin-Beck DiseaseSelenoprotein P gene r25191g/a polymorphism and quantification of selenoprotein P mRNA level in patients with Kashin-Beck disease. PubMed
Kashin-Beck DiseaseSNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease. PubMed
LeukemiaAlteration of gene expressions by the overexpression of mitochondrial phospholipid hydroperoxide glutathione peroxidase (mtPHGPx). PubMed
LeukemiaAmplification and hyperexpression of the catalase gene in selenoperoxidase-deficient leukemia cells. PubMed
LeukemiaCytoprotection against merocyanine 540-sensitized photoinactivation of the Na+,K(+)-adenosine triphosphatase in leukemia cells: glutathione and selenoperoxidase involvement. PubMed
LeukemiaInduction of phospholipid hydroperoxide glutathione peroxidase in human polymorphonuclear neutrophils and HL60 cells stimulated with TNF-alpha. PubMed
LeukemiaOverexpression of phospholipid hydroperoxide glutathione peroxidase suppressed cell death due to oxidative damage in rat basophile leukemia cells (RBL-2H3). PubMed
LeukemiaSelenoperoxidase-mediated cytoprotection against merocyanine 540-sensitized photoperoxidation and photokilling of leukemia cells. PubMed
Leukemia L1210Hyperexpression of catalase in selenium-deprived murine L1210 cells. PubMed
Leukemia L1210Selenoperoxidase-dependent glutathione cycle activity in peroxide-challenged leukemia cells. PubMed
Liver CirrhosisSelenoprotein P mRNA expression in human hepatic tissues. PubMed
Movement DisordersSelenium and brain function: a poorly recognized liaison. PubMed
Muscular AtrophyDenervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria. PubMed
Neoplasm MetastasisTissue microarray assessment of selenoprotein P expression in gastric adenocarcinoma. PubMed
NeoplasmsA thin layer chromatographic method for determining the enzymatic activity of peroxidases catalyzing the two-electron reduction of lipid hydroperoxides. PubMed
NeoplasmsAbsence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity. PubMed
NeoplasmsBlocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy. PubMed
NeoplasmsCoenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells. PubMed
NeoplasmsEffect of selenium on expression of selenoproteins in mouse fibrosarcoma cells. PubMed
NeoplasmsEffects of selenium status, dietary glucosinolate intake and serum glutathione S-transferase ? activity on the risk of benign prostatic hyperplasia. PubMed
NeoplasmsEnhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species. PubMed
NeoplasmsEstablishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial. PubMed
NeoplasmsGlutathione peroxidases and redox-regulated transcription factors. PubMed
NeoplasmsHepatitis B virus X protein induces TNF-alpha expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2. PubMed
NeoplasmsInhibitory effect of phospholipid hydroperoxide glutathione peroxidase on the activity of lipoxygenases and cyclooxygenases. PubMed
NeoplasmsInteraction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk. PubMed
NeoplasmsOverexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFkappaB activation and interleukin-6 release. PubMed
NeoplasmsPhospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma. PubMed
NeoplasmsPhospholipid hydroperoxide glutathione peroxidase is the 18-kDa selenoprotein expressed in human tumor cell lines. PubMed
NeoplasmsPhospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity. PubMed
NeoplasmsPhospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy. PubMed
NeoplasmsRelative abundance of selenoprotein p isoforms in human plasma depends on genotype, se intake, and cancer status. PubMed
NeoplasmsSelenium, but not lycopene or vitamin E, decreases growth of transplantable dunning R3327-H rat prostate tumors. PubMed
NeoplasmsSelenoperoxidase-dependent glutathione cycle activity in peroxide-challenged leukemia cells. PubMed
NeoplasmsSelenoprotein P in plasma in relation to cancer morbidity in middle-aged Swedish men. PubMed
NeoplasmsSelenoproteins and human health: Insights from epidemiological data. PubMed
NeoplasmsStudies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach. PubMed
NeoplasmsSuppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase. PubMed
NeoplasmsTissue microarray assessment of selenoprotein P expression in gastric adenocarcinoma. PubMed
Ovarian NeoplasmsPhospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity. PubMed
Pancreatic NeoplasmsSelenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells. PubMed
Pancreatic NeoplasmsSuppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase. PubMed
phospholipid-hydroperoxide glutathione peroxidase deficiencyAltered hippocampus synaptic function in Selenoprotein P deficient mice. PubMed
phospholipid-hydroperoxide glutathione peroxidase deficiencyPhysiological role of phospholipid hydroperoxide glutathione peroxidase in mammals. PubMed
Pre-EclampsiaSpecific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood. PubMed
Prediabetic StateSerum selenoprotein p levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis. PubMed
Prostatic NeoplasmsInteraction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk. PubMed
Prostatic NeoplasmsReduced serum selenoprotein P concentrations in German prostate cancer patients. PubMed
ProteinuriaEffect of selenium-deficient diet on tubular epithelium in normal rats. PubMed
SeizuresSelenium and brain function: a poorly recognized liaison. PubMed
SepsisNew assay for the measurement of selenoprotein P as a sepsis biomarker from serum. PubMed
Shock, SepticEffects of high doses of selenium, as sodium selenite, in septic shock patients a placebo-controlled, randomized, double-blind, multi-center phase II study--selenium and sepsis. PubMed
Shock, SepticSeleno-enzymes and seleno-compounds: the two faces of selenium. PubMed
Shock, SepticSelenoprotein P, Rather than Glutathione Peroxidase, as a Potential Marker of Septic Shock and Related Syndromes. PubMed
SilicosisSerum selenium and selenoprotein P in patients with silicosis. PubMed
StarvationMolecular characterization of a phospholipid-hydroperoxide glutathione peroxidase from the bumblebee Bombus ignitus. PubMed
StarvationMolecular characterization of phospholipid hydroperoxide glutathione peroxidases from Hydra vulgaris. PubMed
StrokeDepressed serum selenoprotein P: possible new predicator of increased risk for cerebrovascular events. PubMed
StrokeThe C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension. PubMed
Thyroid DiseasesBone Turnover and Bone Mineral Density Are Independently Related to Selenium Status in Healthy Euthyroid Postmenopausal Women. PubMed
ThyroiditisSelenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3. PubMed
Trypanosomiasis, AfricanAlternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P. PubMed
Vitamin E DeficiencyVitamin E deficiency has different effects on brain and liver phospholipid hydroperoxide glutathione peroxidase activities in the rat. PubMed
Wilms TumorMolecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression. PubMed

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISMLINK TO PUBMEDSOURCE
394864Ursini, F.; Maiorini, M.; Gregolin, C.The selenoenzyme phospholipid hydroperoxide glutathione peroxidaseBiochim. Biophys. Acta83962-701985Sus scrofa PubMed
394865Maiorino, M.; Roveri, A.; Gregolin, C.; Ursini, F.Different effects of Triton X-100, deoxycholate, and fatty acids on the kinetics of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidaseArch. Biochem. Biophys.251600-6051986Sus scrofa PubMed
394866Panfili, E.; Sandri, G.; Ernster, L.Distribution of glutathione peroxidases and glutathione reductase in rat brain mitochondriaFEBS Lett.29035-371991Rattus norvegicus PubMed
394867Maiorino, M.; Gregolin, C.; Ursini, F.Phospholipid hydroperoxide glutathione peroxidaseMethods Enzymol.186448-4571990Bos taurus, Canis lupus familiaris, Rattus norvegicus, Sus scrofa PubMed
394868Ursini, F.; Maiorino, M.; Valente, M.; Ferri, L.; Gregolin, C.Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxidesBiochim. Biophys. Acta710197-2111982Sus scrofa PubMed
394869Maiorino, M.; Ursini, F.; Leonelli, M.; Finato, N.; Gregolin, C.A pig heart peroxidation inhibiting protein with glutathione peroxidase activity on phospholipid hydroperoxidesBiochem. Int.5575-5811982Sus scrofa-
394870Thomas, J.P.; Geiger, P.G.; Maiorino, M.; Ursini, F.; Girotti, A.W.Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteinsBiochim. Biophys. Acta1045252-2601990Sus scrofa PubMed
394871Zhang, L.; Maiorini, M.; Roveri, A.; Ursini, F.Phospholipid hydroperoxide glutathione peroxidase: specific activity in tissues of rats of different age and comparison with other glutathione peroxidasesBiochim. Biophys. Acta1006140-1431989Rattus norvegicus PubMed
394872Avsian-Kretchmer, O.; Eshdat, Y.; Gueta-Dahan, Y.; Ben-Hayyim, G.Regulation of stress-induced phospholipid hydroperoxide glutathione peroxidase expression in citrusPlanta209469-4771999Citrus sinensis PubMed
394873Saito, Y.; Hayashi, T.; Tanaka, A.; Watanabe, Y.; Suzuki, M.; Saito, E.; Takahashi, K.Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein PJ. Biol. Chem.2742866-28711999Homo sapiens PubMed
394874Avery, A.M.; Avery, S.V.Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidasesJ. Biol. Chem.27633730-337352001Saccharomyces cerevisiae PubMed
394875Wilkinson, S.R.; Meyer, D.J.; Kelly, J.M.Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activityBiochem. J.352755-7612000Trypanosoma cruzi PubMed
394876Lam, K.W.; Wang, L.; Hong, B.S.; Treble, D.Purification of phospholipid hydroperoxide glutathione peroxidase from bovine retinaCurr. Eye Res.129-151993Bos taurus PubMed
394877Tramer, F.; Micali, F.; Sandri, G.; Bertoni, A.; Lenzi, A.; Gandini, L.; Panfili, E.Enzymatic and immunochemical evaluation of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in testes and epididymal spermatozoa of rats of different agesInt. J. Androl.2572-832002Rattus norvegicus PubMed
394878Chambers, S.J.; Lambert, N.; Williamson, G.Purification of a cytosolic enzyme from human liver with phospholipid hydroperoxide glutathione peroxidase activityInt. J. Biochem.261279-12861994Homo sapiens PubMed
394879Schnurr, K.; Borchert, A.; Gerth, C.; Anton, M.; Kuhn, H.Bacterial and nonbacterial expression of wild-type and mutant human phospholipid hydroperoxide glutathione peroxidase and purification of the mutant enzyme in the milligram scaleProtein Expr. Purif.19403-4102000Homo sapiens PubMed
394880Roveri, A.; Maiorino, M.; Nisii, C.; Ursini, F.Purification and characterization of phospholipid hydroperoxide glutathione peroxidase from rat testis mitochondrial membranesBiochim. Biophys. Acta1208211-2211994Rattus norvegicus PubMed
394881Sattler, W.; Maiorino, M.; Stocker, R.Reduction of HDL- and LDL-associated cholesterylester and phospholipid hydroperoxides by phospholipid hydroperoxide glutathione peroxidase and ebselen (PZ 51)Arch. Biochem. Biophys.309214-2211994Sus scrofa PubMed
394882Maiorino, M.; Roche, C.; Kiess, M.; Koenig, K.; Gawlik, D.; Matthes, M.; Naldini, E.; Pierce, R.; Flohe, L.A selenium-containing phospholipid-hydroperoxide glutathione peroxidase in Schistosoma mansoniEur. J. Biochem.238838-8441996Schistosoma mansoni PubMed
394883Nomura, K.; Imai, H.; Koumura, T.; Kobayashi, T.; Nakagawa, Y.Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosisBiochem. J.351183-1932000Rattus norvegicus PubMed
658247Foresta, C.; Flohe, L.; Garolla, A.; Roveri, A.; Ursini, F.; Maiorino, M.Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidaseBiol. Reprod.67967-9712002Homo sapiens PubMed
658251Nagdas, S.K.; Winfrey, V.P.; Olson, G.E.Tyrosine phosphorylation generates multiple isoforms of the mitochondrial capsule protein, phospholipid hydroperoxide glutathione peroxidase (PHGPx), during hamster sperm capacitationBiol. Reprod.72164-1712005Mesocricetus auratus PubMed
658606Herbette, S.; Lenne, C.; Leblanc, N.; Julien, J.L.; Drevet, J.R.; Roeckel-Drevet, P.Two GPX-like proteins from Lycopersicon esculentum and Helianthus annuus are antioxidant enzymes with phospholipid hydroperoxide glutathione peroxidase and thioredoxin peroxidase activitiesEur. J. Biochem.2692414-24202002Solanum lycopersicum PubMed
658758Maiorino, M.; Mauri, P.; Roveri, A.; Benazzi, L.; Toppo, S.; Bosello, V.; Ursini, F.Primary structure of the nuclear forms of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in rat spermatozoaFEBS Lett.579667-6702005Rattus norvegicus PubMed
658926Tramer, F.; Caponecchia, L.; Sgro, P.; Martinelli, M.; Sandri, G.; Panfili, E.; Lenzi, A.; Gandini, L.Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR)does not differ between normo- and hypomotile human sperm samplesInt. J. Androl.2788-932004Homo sapiens PubMed
659398Utomo, A.; Jiang, X.; Furuta, S.; Yun, J.; Levin, D.S.; Wang, Y.C.; Desai, K.V.; Green, J.E.; Chen, P.L.; Lee, W.H.Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cellsJ. Biol. Chem.27943522-435292004Homo sapiens PubMed
659647Li, D.; Blasevich, F.; Theopold, U.; Schmidt, O.Possible function of two insect phospholipid-hydroperoxide glutathione peroxidasesJ. Insect Physiol.491-92003Drosophila melanogaster, Venturia canescens PubMed
671327Diaconu, M.; Tangat, Y.; Boehm, D.; Kuehn, H.; Michelmann, H.W.; Schreiber, G.; Haidl, G.; Glander, H.J.; Engel, W.; Nayernia, K.Failure of phospholipid hydroperoxide glutathione peroxidase expression in oligoasthenozoospermia and mutations in the PHGPx geneAndrologia38152-1572006Homo sapiens PubMed
671713Hattori, H.; Imai, H.; Furuhama, K.; Sato, O.; Nakagawa, Y.Induction of phospholipid hydroperoxide glutathione peroxidase in human polymorphonuclear neutrophils and HL60 cells stimulated with TNF-alphaBiochem. Biophys. Res. Commun.337464-4732005Homo sapiens PubMed
671833Hattori, H.; Imai, H.; Hanamoto, A.; Furuhama, K.; Nakagawa, Y.Up-regulation of phospholipid hydroperoxide glutathione peroxidase in rat casein-induced polymorphonuclear neutrophilsBiochem. J.389279-2872005Rattus norvegicus PubMed
672372Januel, C.; El Hentati, F.; Carreras, M.; Arthur, J.R.; Calzada, C.; Lagarde, M.; Vericel, E.Phospholipid-hydroperoxide glutathione peroxidase (GPx-4) localization in resting platelets, and compartmental change during platelet activationBiochim. Biophys. Acta17611228-12342006Homo sapiens PubMed
673176Puglisi, R.; Tramer, F.; Carlomagno, G.; Gandini, L.; Panfili, E.; Stefanini, M.; Lenzi, A.; Mangia, F.; Boitani, C.PHGPx in spermatogenesis: how many functions?Contraception72291-2932005Rattus norvegicus PubMed
673343Lapointe, J.; Kimmins, S.; Maclaren, L.A.; Bilodeau, J.F.Estrogen selectively up-regulates the phospholipid hydroperoxide glutathione peroxidase in the oviductsEndocrinology1462583-25922005Bos taurus PubMed
673807Steinbrenner, H.; Bilgic, E.; Alili, L.; Sies, H.; Brenneisen, P.Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activityFree Radic. Res.40936-9432006Homo sapiens PubMed
673837Dash, B.; Metz, R.; Huebner, H.J.; Porter, W.; Phillips, T.D.Molecular characterization of phospholipid hydroperoxide glutathione peroxidases from Hydra vulgarisGene3811-122006Hydra vulgaris PubMed
673845Schneider, M.; Vogt Weisenhorn, D.M.; Seiler, A.; Bornkamm, G.W.; Brielmeier, M.; Conrad, M.Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidaseGene Expr. Patterns6489-4942006Mus musculus PubMed
673931Liu, J.; Du, J.; Zhang, Y.; Sun, W.; Smith, B.J.; Oberley, L.W.; Cullen, J.J.Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidaseHum. Gene Ther.17105-1162006Homo sapiens PubMed
674008Cossio-Bayugar, R.; Miranda, E.; Holman, P.J.Molecular cloning of a phospholipid-hydroperoxide glutathione peroxidase gene from the tick, Boophilus microplus (Acari: Ixodidae)Insect Biochem. Mol. Biol.351378-13872005Rhipicephalus microplus PubMed
674370Imai, H.; Saito, M.; Kirai, N.; Hasegawa, J.; Konishi, K.; Hattori, H.; Nishimura, M.; Naito, S.; Nakagawa, Y.Identification of the positive regulatory and distinct core regions of promoters, and transcriptional regulation in three types of mouse phospholipid hydroperoxide glutathione peroxidaseJ. Biochem.140573-5902006Mus musculus PubMed
674502Maiorino, M.; Roveri, A.; Benazzi, L.; Bosello, V.; Mauri, P.; Toppo, S.; Tosatto, S.C.; Ursini, F.Functional interaction of phospholipid hydroperoxide glutathione peroxidase with sperm mitochondrion-associated cysteine-rich protein discloses the adjacent cysteine motif as a new substrate of the selenoperoxidaseJ. Biol. Chem.28038395-384022005Rattus norvegicus PubMed
674598Borchert, A.; Wang, C.C.; Ufer, C.; Schiebel, H.; Savaskan, N.E.; Kuhn, H.The role of phospholipid hydroperoxide glutathione peroxidase isoforms in murine embryogenesisJ. Biol. Chem.28119655-196642006Mus musculus PubMed
675048Kriska, T.; Girotti, A.W.A thin layer chromatographic method for determining the enzymatic activity of peroxidases catalyzing the two-electron reduction of lipid hydroperoxidesJ. Chromatogr. B82758-642005Homo sapiens PubMed
675965Conrad, M.; Moreno, S.G.; Sinowatz, F.; Ursini, F.; Koelle, S.; Roveri, A.; Brielmeier, M.; Wurst, W.; Maiorino, M.; Bornkamm, G.W.The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stabilityMol. Cell. Biol.257637-76442005Mus musculus PubMed
676554Yang, X.D.; Dong, C.J.; Liu, J.Y.A plant mitochondrial phospholipid hydroperoxide glutathione peroxidase: its precise localization and higher enzymatic activityPlant Mol. Biol.62951-9622006Raphanus sativus PubMed
685185Scheerer, P.; Borchert, A.; Krauss, N.; Wessner, H.; Gerth, C.; Hoehne, W.; Kuhn, H.Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4)Biochemistry469041-90492007Homo sapiens PubMed
685440Conrad, M.; Schneider, M.; Seiler, A.; Bornkamm, G.W.Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammalsBiol. Chem.3881019-10252007Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa PubMed
686071Wang, F.; Zhou, H.; Kong, B.; Fan, J.; Chen, H.; Liu, J.Urea-induced inactivation and unfolding of recombinant phospholipid hydroperoxide glutathione peroxidase from Oryza sativaChem. Res. Chin. Univ.23562-5662007Oryza sativa PubMed
686405Puglisi, R.; Bevilacqua, A.; Carlomagno, G.; Lenzi, A.; Gandini, L.; Stefanini, M.; Mangia, F.; Boitani, C.Mice overexpressing the mitochondrial phospholipid hydroperoxide glutathione peroxidase in male germ cells show abnormal spermatogenesis and reduced fertilityEndocrinology1484302-43092007Mus musculus PubMed
686888Dabkowski, E.R.; Williamson, C.L.; Hollander, J.M.Mitochondria-specific transgenic overexpression of phospholipid hydroperoxide glutathione peroxidase (GPx4) attenuates ischemia/reperfusion-associated cardiac dysfunctionFree Radic. Biol. Med.45855-8652008Mus musculus PubMed
686896Cejas, P.; Garcia-Cabezas, M.A.; Casado, E.; Belda-Iniesta, C.; De Castro, J.; Fresno, J.A.; Sereno, M.; Barriuso, J.; Espinosa, E.; Zamora, P.; Feliu, J.; Redondo, A.; Hardisson, D.A.; Renart, J.; Gonzalez-Baron, M.Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinomaFree Radic. Res.41681-6872007Homo sapiens PubMed
687186Cai, G.B.; Bae, Y.A.; Kim, S.H.; Sohn, W.M.; Lee, Y.S.; Jiang, M.S.; Kim, T.S.; Kong, Y.Vitellocyte-specific expression of phospholipid hydroperoxide glutathione peroxidases in Clonorchis sinensisInt. J. Parasitol.381613-16232008Clonorchis sinensis PubMed
687471Wang, Z.; Wang, F.; Duan, R.; Liu, J.Y.Purification and physicochemical characterization of a recombinant phospholipid hydroperoxide glutathione peroxidase from Oryza sativaJ. Biochem. Mol. Biol.40412-4182007Oryza sativa PubMed
688464Baek, I.J.; Seo, D.S.; Yon, J.M.; Lee, S.R.; Jin, Y.; Nahm, S.S.; Jeong, J.H.; Choo, Y.K.; Kang, J.K.; Lee, B.J.; Yun, Y.W.; Nam, S.Y.Tissue expression and cellular localization of phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA in male miceJ. Mol. Histol.38237-2442007Mus musculus PubMed
688724Baek, I.J.; Yon, J.M.; Lee, S.R.; Jin, Y.; Kim, M.R.; Ahn, B.; Hong, J.T.; Choo, Y.K.; Lee, B.J.; Yun, Y.W.; Nam, S.Y.Effects of endocrine disrupting chemicals on expression of phospholipid hydroperoxide glutathione peroxidase mRNA in rat testesJ. Vet. Sci.8213-2182007Rattus norvegicus PubMed
688924Ding, W.Q.; Lind, S.E.Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicityMol. Cancer Ther.61467-14742007Homo sapiens PubMed
689838Zafiriou, M.P.; Deva, R.; Ciccoli, R.; Siafaka-Kapadai, A.; Nigam, S.Biological role of hepoxilins: upregulation of phospholipid hydroperoxide glutathione peroxidase as a cellular response to oxidative stress?Prostaglandins Leukot. Essent. Fatty Acids77209-2152007Rattus norvegicus PubMed
696173Dong, C.J.; Yang, X.D.; Liu, J.Y.Enzymatic properties of a recombinant phospholipid hydroperoxide glutathione peroxidase from Momordica charantia and its complementation function in yeastBiochemistry (Moscow)74502-5082009Momordica charantia PubMed
696435Conrad, M.Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4Biochim. Biophys. Acta17901575-15852009Mus musculus PubMed
696970Bae, Y.; Cai, G.; Kim, S.; Zo, Y.; Kong, Y.Modular evolution of glutathione peroxidase genes in association with different biochemical properties of their encoded proteins in invertebrate animalsBMC Evol. Biol.91-132009animal PubMed
697468Hu, Z.; Lee, K.S.; Choo, Y.M.; Yoon, H.J.; Kim, I.; Wei, Y.D.; Gui, Z.Z.; Zhang, G.Z.; Sohn, H.D.; Jin, B.R.Molecular characterization of a phospholipid-hydroperoxide glutathione peroxidase from the bumblebee Bombus ignitusComp. Biochem. Physiol. B15554-612010Bombus ignitus PubMed
697470Hermesz, E.; Ferencz, A.Identification of two phospholipid hydroperoxide glutathione peroxidase (gpx4) genes in common carpComp. Biochem. Physiol. C150101-1062009Cyprinus carpio PubMed
697778Kadota, Y.; Suzuki, S.; Ideta, S.; Fukinbara, Y.; Kawakami, T.; Imai, H.; Nakagawa, Y.; Sato, M.Enhanced metallothionein gene expression induced by mitochondrial oxidative stress is reduced in phospholipid hydroperoxide glutathione peroxidase-overexpressed cellsEur. J. Pharmacol.626166-1702009Rattus norvegicus PubMed
698037Chen, H.; Lin, C.; Ken, C.; Wen, L.; Lin, C.Putative phospholipid hydroperoxide glutathione peroxidase from Antrodia camphorataFood Chem.115476-4822009Taiwanofungus camphoratus-
698045Guo, Z.; Ran, Q.; Roberts, L.J.; Zhou, L.; Richardson, A.; Sharan, C.; Wu, D.; Yang, H.Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient miceFree Radic. Biol. Med.44343-3522008Homo sapiens PubMed
701033Li, T.; Yang, X.; Liu, J.Tissue and induction expression profiles of rice phospholipid hydroperoxide glutathione peroxidase at protein levelProg. Biochem. Biophys.3677-822009Oryza sativa-
701060Kernstock, R.M.; Girotti, A.W.New strategies for the isolation and activity determination of naturally occurring type-4 glutathione peroxidaseProtein Expr. Purif.62216-2222008Rattus norvegicus PubMed
701118Zhang, W.; He, Y.; Yang, Z.; Yu, J.; Chen, Y.; Zhou, C.Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiaeProteins Struct. Funct. Genet.731058-10622008Saccharomyces cerevisiae PubMed
701138Dimastrogiovanni, D.; Anselmi, M.; Miele, A.E.; Boumis, G.; Petersson, L.; Angelucci, F.; Nola, A.D.; Brunori, M.; Bellelli, A.Combining crystallography and molecular dynamics: The case of Schistosoma mansoni phospholipid glutathione peroxidaseProteins78259-2702009Schistosoma mansoni PubMed
701272Stradaioli, G.; Sylla, L.; Monaci, M.; Maiorino, M.Phospholipid hydroperoxide glutathione peroxidase in bull spermatozoa provides a unique marker in the quest for semen quality analysisTheriogenology7291-982009Bos taurus PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 1.11.1.12)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)