Information on EC 1.1.1.225 - chlordecone reductase:
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The lowest common taxonomy group for this enzyme is: Euarchontoglires

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EC NUMBERCOMMENTARY
1.1.1.225-

RECOMMENDED NAMEGeneOntology No.
chlordecone reductaseGO:0047743

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
chlordecone alcohol + NADP+ = chlordecone + NADPH + H+
show the reaction diagram		----

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
oxidation----
redox reaction----
reduction----

PATHWAYKEGG LinkMetaCyc Link
No entries in this field

SYSTEMATIC NAMEIUBMB Comments
chlordecone-alcohol:NADP+ 2-oxidoreductaseChlordecone is an organochlorine pesticide.

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
CDR----
reductase, chlordecone----

CAS REGISTRY NUMBERCOMMENTARY
102484-73-1-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
Homo sapiens-286316, 286317, 286318, 286319--Manually annotated by BRENDA team
Meriones unguiculatus-286316, 286318--Manually annotated by BRENDA team
no activity in Cavia porcellus-286316--Manually annotated by BRENDA team
no activity in Mesocricetus auratus-286316, 286318--Manually annotated by BRENDA team
no activity in Mus musculus-286316, 286318--Manually annotated by BRENDA team
no activity in Rattus norvegicus-286316, 286318--Manually annotated by BRENDA team
Oryctolagus cuniculus-286316, 286318--Manually annotated by BRENDA team

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY/
Substrate		 LITERATURE/
Substrate		 COMMENTARY/
Product		 LITERATURE/
Product		 Reversibility
r=reversible
ir=irreversible
?=not specified
1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPHchlordecone alcohol + NADP+
show the reaction diagram		Homo sapiens, Oryctolagus cuniculus, Meriones unguiculatus--286318-286318?
1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPHchlordecone alcohol + NADP+
show the reaction diagram		Homo sapiens, Oryctolagus cuniculus, Meriones unguiculatus-organochlorine pesticide, trivial names: chlordecone or kepone286316-286316?

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY SUBSTRATELITERATURE
(Substrate)		COMMENTARY PRODUCTLITERATURE
(Product)
No entries in this field

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
NADPHHomo sapiens, Meriones unguiculatus, Oryctolagus cuniculus--286316, 286318 2D-image
additional informationHomo sapiens-no activity with NADH286318-

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
No entries in this field

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
Cu2+Homo sapiens, Meriones unguiculatus-slight inhibition286318 2D-image
Ethacrynic acidHomo sapiens, Meriones unguiculatus--286316, 286318 2D-image
Hg2+Homo sapiens, Meriones unguiculatus-slight inhibition286318 2D-image
p-chloromercuribenzoateHomo sapiens--286316, 286318 2D-image
p-chloromercuribenzoateMeriones unguiculatus-strong inhibition286316 2D-image
p-chloromercuribenzoateMeriones unguiculatus--286318 2D-image
quercetinHomo sapiens--286316, 286318 2D-image
quercetinMeriones unguiculatus-weak inhibition286316 2D-image
quercetinMeriones unguiculatus--286318 2D-image
IndomethacinHomo sapiens, Meriones unguiculatus--286316, 286318 2D-image
additional informationHomo sapiens, Meriones unguiculatus-not inhibited by phenobarbital286316, 286318-

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
0.0026-ChlordeconeMeriones unguiculatus--286316 2D-image
0.003-ChlordeconeHomo sapiens, Meriones unguiculatus--286318 2D-image
0.005-NADPHMeriones unguiculatus--286316 2D-image

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
0.008-Homo sapiens--286318

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
6.5-Meriones unguiculatus--286316
7.5-Homo sapiens-2 optima: pH 7.5 and 9.0286318
9-Homo sapiens-2 optima: pH 7.5 and 9.0286318

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
brainMeriones unguiculatus--286316Manually annotated by BRENDA team
heartMeriones unguiculatus--286316Manually annotated by BRENDA team
intestineMeriones unguiculatus--286316Manually annotated by BRENDA team
kidneyMeriones unguiculatus--286316Manually annotated by BRENDA team
liverHomo sapiens, Meriones unguiculatus, Oryctolagus cuniculus--286316, 286318Manually annotated by BRENDA team
spleenMeriones unguiculatus--286316Manually annotated by BRENDA team
lungMeriones unguiculatus--286316Manually annotated by BRENDA team
additional informationMeriones unguiculatus-found in all tissues, highest activity in liver, intestine and kidney286316Manually annotated by BRENDA team

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
cytoplasmHomo sapiens, Meriones unguiculatus, Oryctolagus cuniculus--5737286316, 286318Manually annotated by BRENDA team

PDBSCOPCATHORGANISM
No entries in this field

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
No entries in this field

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-70°C, 50% glycerolHomo sapiens-286318

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
-Homo sapiens-286318

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
expressed in Escherichia coliHomo sapiens-286317
gene is located on chromosome 10 at 10p14-p15Homo sapiens-286319

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

DISEASETITLE OF PUBLICATIONLINK TO PUBMED
No entries in this field

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISMLINK TO PUBMEDSOURCE
286316Molowa, D.T.; Wrighton, S.A.; Blanke, R.V.; Guzelian, P.S.Characterization of a unique aldo-keto reductase responsible for the reduction of chlordecone in the liver of the gerbil and manJ. Toxicol. Environ. Health17375-3841986Homo sapiens, Meriones unguiculatus, no activity in Cavia porcellus, no activity in Mesocricetus auratus, no activity in Mus musculus, no activity in Rattus norvegicus, Oryctolagus cuniculus PubMed
286317Winters, C.J.; Molowa, D.T.; Guzelian, P.S.Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductaseBiochemistry291080-10871990Homo sapiens PubMed
286318Molowa, D.T.; Shayne, A.G.; Guzelian, P.S.Purification and characterization of chlordecone reductase from human liverJ. Biol. Chem.26112624-126271986Homo sapiens, Meriones unguiculatus, no activity in Mesocricetus auratus, no activity in Mus musculus, no activity in Rattus norvegicus, Oryctolagus cuniculus PubMed
286319Khanna, M.; Qin, I.; Belkin, S.; Sparkes, R.S.; Cheng, K.C.Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridizationGenomics25588-5901995Homo sapiens PubMed

LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.225)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)