format-version: 1.2
date: 21:05:2009 21:34
auto-generated-by: OBO-Edit 2.000-beta49

[Term]
id: BTO:0000000
name: brenda source tissue ontology
namespace: BrendaTissueOBO
def: "A structured controlled vocabulary for the source of an enzyme. It comprises terms of tissues, cell lines, cell types and cell cultures from uni- and multicellular organisms." [curators:mgr]

[Term]
id: BTO:0000001
name: culture condition:-induced cell
namespace: BrendaTissueOBO
is_a: BTO:0000216 ! culture condition

[Term]
id: BTO:0000002
name: culture condition:1,4-dichlorobenzene-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000003
name: intestinal cell line
namespace: BrendaTissueOBO
relationship: DRV BTO:0000648 ! intestine

[Term]
id: BTO:0000004
name: culture condition:2,5-dihydroxybenzoate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000005
name: culture condition:2-aminobenzenesulfonate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000006
name: osteoblastoma cell
namespace: BrendaTissueOBO
def: "A benign tumor cell of bone. " [Fast Health Medical Dictionary:http\://www.fasthealth.com/dictionary/]
is_a: BTO:0000372 ! bone cancer cell
relationship: DRV BTO:0001593 ! osteoblast

[Term]
id: BTO:0000007
name: HEK-293 cell
namespace: BrendaTissueOBO
def: "Established from a human primary embryonal kidney transformed by adenovirus type 5." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
synonym: "293 cell" RELATED []
synonym: "A-293 cell" RELATED []
synonym: "A293 cell" RELATED []
synonym: "HEK cell" RELATED []
synonym: "HEK293 cell" RELATED []
synonym: "human embryonal kidney cell" RELATED []
synonym: "human embryonic kidney cell" RELATED []
is_a: BTO:0000067 ! kidney cell line
is_a: BTO:0002733 ! embryonic kidney cell line

[Term]
id: BTO:0000008
name: culture condition:3-chlorobenzoate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000009
name: culture condition:3-hydroxybenzoate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000010
name: culture condition:3-methylcrotonoyl-CoA-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000011
name: 3T3-L1 cell
namespace: BrendaTissueOBO
def: "L1 is a continuous substrain of 3T3 (Swiss albino) developed through clonal isolation. Cells undergo a pre-adipose to adipose like conversion as they progress from a rapidly dividing to a confluent and contact inhibited state. A high serum content in the medium enhances fat accumulation." [ATCC American Cell Type Culture Collection:http\://www.lgcstandards-atcc.org/]
relationship: DRV BTO:0000944 ! NIH-3T3 cell

[Term]
id: BTO:0000012
name: culture condition:4-(methoxymethyl)phenol-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000013
name: culture condition:4-chlorophenol-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000014
name: culture condition:4-hydroxybenzoate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000015
name: culture condition:4-methylmuconolactone-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000016
name: A-172 cell
namespace: BrendaTissueOBO
def: "Human brain glioblastoma cell line. Established from a 53 year old man." [ATCC American Cell Type Culture Collection:http\://www.lgcstandards-atcc.org/]
synonym: "A172 cell" RELATED []
is_a: BTO:0001530 ! glioblastoma cell line

[Term]
id: BTO:0000017
name: A-431 cell
namespace: BrendaTissueOBO
def: "Human epidermoid carcinoma established from the solid tumor of an 85-year-old woman; cells were reported to have large numbers of EGF binding sites; cell line was used as indicator cell line for anti-TGF binding." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
synonym: "A431 cell" RELATED []
is_a: BTO:0000297 ! carcinoma cell line

[Term]
id: BTO:0000018
name: A-549 cell
namespace: BrendaTissueOBO
def: "Human lung carcinoma established from an explanted lung tumor which was removed from a 58-year-old Caucasian man in 1972; cells were described to induce tumors in athmyic mice and to synthesize lecithin." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
synonym: "A549 cell" RELATED []
synonym: "NCI-A549 cell" RELATED []
is_a: BTO:0000762 ! lung cancer cell line

[Term]
id: BTO:0000019
name: A7r5 cell
namespace: BrendaTissueOBO
def: "Rat embryonic thoracic aorta smooth muscle cell line. The cells exhibit an increase in activity of the enzymes myokinase and creatine phosphokinase (CPK) as the culture reaches stationary phase. Muscle type CPK is synthesized after cell division has ceased." [ATCC American Cell Type Culture Collection:http\://www.lgcstandards-atcc.org/]
is_a: BTO:0000669 ! embryonic cell line
is_a: BTO:0001200 ! aorta thoracica smooth muscle cell line

[Term]
id: BTO:0000020
name: abdomen
namespace: BrendaTissueOBO
def: "1: The part of the body between the thorax and the pelvis; also: the cavity of this part of the trunk containing the chief viscera.\n2: The posterior section of the body behind the thorax in an arthropod." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=abdomen]
synonym: "abdominal cavity" RELATED []
relationship: part_of BTO:0001493 ! trunk

[Term]
id: BTO:0000021
name: head muscle
namespace: BrendaTissueOBO
is_a: BTO:0001103 ! skeletal muscle
relationship: part_of BTO:0000282 ! head

[Term]
id: BTO:0000022
name: abdominal ganglion
namespace: BrendaTissueOBO
def: "The visceral sac's nerve knot is called visceral ganglion. In contrary to the mostly paired other ganglia this nerve knot is unpaired. The visceral ganglion innerves the pallial organs as well as the inner organs." [:Biology, :Czihak, :Langer, :Ziegler, Snails Nervous System:1992]
synonym: "visceral ganglion" RELATED []
is_a: BTO:0000497 ! ganglion
relationship: part_of BTO:0001448 ! visceral hump

[Term]
id: BTO:0000023
name: pectoral muscle
namespace: BrendaTissueOBO
def: "Any of the muscles which connect the ventral walls of the chest with the bones of the upper arm and shoulder and of which there are two on each side of the human body." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=pectoral+muscle]
synonym: "breast muscle" RELATED []
synonym: "pectoralis muscle" RELATED []
is_a: BTO:0000508 ! thorax muscle

[Term]
id: BTO:0000024
name: abomasum
namespace: BrendaTissueOBO
def: "The fourth compartment of the ruminant stomach that follows the omasum and has a true digestive function." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=abomasum]
synonym: "fourth stomach" RELATED []
is_a: BTO:0001307 ! stomach

[Term]
id: BTO:0000025
name: amniotic cavity
namespace: BrendaTissueOBO
def: "The space within the amnion." [Medical Dictionary:http\://www.edoc.co.za/medilink/dict/359.html]
relationship: part_of BTO:0000065 ! amnion

[Term]
id: BTO:0000026
name: culture condition:galactose-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000027
name: achene
namespace: BrendaTissueOBO
def: "A small dry indehiscent one-seeded fruit (as of a sunflower) developing from a simple ovary and usually having a thin pericarp attached to the seed at only one point." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
is_a: BTO:0000486 ! fruit

[Term]
id: BTO:0000028
name: pancreatic acinar cell
namespace: BrendaTissueOBO
def: "Cells of the pancreas that secrete digestive enzymes, the archetypal secretory cell upon which much of the early work on the sequence of events in the secretory process was done. " [Online Medical Dictionary:http\://cancerweb.ncl.ac.uk/]
synonym: "exocrine pancreas cell" RELATED []
synonym: "pancreatic acinus" RELATED []
is_a: BTO:0000433 ! exocrine acinar cell
relationship: part_of BTO:0000434 ! exocrine pancreas

[Term]
id: BTO:0000029
name: adductor longus
namespace: BrendaTissueOBO
def: "Adductor arising from the superior ramus of the pubis and inserted into the middle third of the linea aspera." [Fast Health Medical Dictionary:http\://www.fasthealth.com/dictionary/]
synonym: "long adductor muscle" RELATED []
synonym: "musculus adductor longus" RELATED []
is_a: BTO:0000030 ! adductor

[Term]
id: BTO:0000030
name: adductor
namespace: BrendaTissueOBO
def: "Any of three powerful triangular muscles that contribute to the adduction of the human thigh." [Fast Health Medical Dictionary:http\://www.fasthealth.com/dictionary/]
synonym: "adductor muscle" RELATED []
is_a: BTO:0001367 ! thigh muscle
relationship: part_of BTO:0001376 ! thigh

[Term]
id: BTO:0000031
name: fruit peduncle
namespace: BrendaTissueOBO
relationship: part_of BTO:0000486 ! fruit

[Term]
id: BTO:0000032
name: colonic adenocarcinoma cell
namespace: BrendaTissueOBO
def: "A cell of an adenocarcinoma of the colon is a malignant neoplastic epithelial lesion, arising from the colonic mucosa." [Brown Medical School \, Digital Pathology:http\://www.brown.edu/Courses/Digital_Path/GI/colonic_adenocarcinoma.htm]
synonym: "adenocarcinoma cell, colon" RELATED []
synonym: "colon adenocarcinoma cell" RELATED []
is_a: BTO:0000035 ! colorectal adenocarcinoma cell
is_a: BTO:0000586 ! colonic cancer cell

[Term]
id: BTO:0000033
name: SW-403 cell
namespace: BrendaTissueOBO
def: "Human colon adenocarcinoma, established from the adenocarcinoma (grade III) of a 51-year-old Caucasian woman; cells were described to produce carcinoembryonic antigen (CEA) and to be tumorigenic in nude mice." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
synonym: "SW403 cell" RELATED []
is_a: BTO:0001913 ! colonic adenocarcinoma cell line

[Term]
id: BTO:0000034
name: apical meristem
namespace: BrendaTissueOBO
def: "A group of cells at the tip of the stem and root that give rise by cell division to the primary tissues and are ultimately responsible for the structural organization of the entire primary plant body." [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
synonym: "GRO:0000231" RELATED []
relationship: part_of BTO:0000247 ! shoot tip
relationship: part_of BTO:0001191 ! root tip
relationship: part_of BTO:0001300 ! stem

[Term]
id: BTO:0000035
name: colorectal adenocarcinoma cell
namespace: BrendaTissueOBO
def: "Adenocarcinoma cell related to the colon and/or rectum." [Medical Dictionary:http\://www.medterms.com/]
synonym: "adenocarcinoma cell, colorectal" RELATED []
is_a: BTO:0000193 ! rectal cancer cell
is_a: BTO:0000586 ! colonic cancer cell
is_a: BTO:0000604 ! adenocarcinoma cell

[Term]
id: BTO:0000036
name: gastric adenocarcinoma cell
namespace: BrendaTissueOBO
def: "A cell of any of a group of common stomach cancers, usually located in the antrum; it may present as a bulky mass with central ulceration invading the wall, a mass that narrows the antral lumen, a polypoid lesion, or a tumor that spreads superficially over the mucosal surface. It is common in Japan, Chile, Iceland, and Finland but the incidence is decreasing in North America and elsewhere. There may be links to certain dietary substances such as nitrosamines and benzpyrene." [Dorlands Medical Dictionary:MerckSource]
synonym: "adenocarcinoma cell of the stomach" RELATED []
synonym: "gastric carcinoma cell" RELATED []
is_a: BTO:0000498 ! gastric cancer cell
is_a: BTO:0000604 ! adenocarcinoma cell

[Term]
id: BTO:0000037
name: renal cell carcinoma cell
namespace: BrendaTissueOBO
def: "Carcinoma cell of the renal parenchyma usually occurring in middle age or later and composed of tubular cells in varying arrangements; symptoms depend on extent of invasion." [Dorlands Medical Dictionary:MerckSource]
synonym: "adenocarcinoma cell of kidney" RELATED []
synonym: "CCRCC cell" RELATED []
synonym: "clear cell carcinoma cell" RELATED []
synonym: "clear cell renal cell carcinoma cell" RELATED []
synonym: "Grawitz`s tumor cell" RELATED []
synonym: "hypernephroid carcinoma cell" RELATED []
synonym: "hypernephroma cell" RELATED []
synonym: "kidney adenocarcinoma cell" RELATED []
synonym: "renal adenocarcinoma cell" RELATED []
is_a: BTO:0000604 ! adenocarcinoma cell
is_a: BTO:0000680 ! kidney cancer cell

[Term]
id: BTO:0000038
name: SW-480 cell
namespace: BrendaTissueOBO
def: "Human colon adenocarcinoma, established from the tumor of a 50-year-old Caucasian man with colon adenocarcinoma." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
synonym: "SW480 cell" RELATED []
is_a: BTO:0001913 ! colonic adenocarcinoma cell line

[Term]
id: BTO:0000039
name: root cap
namespace: BrendaTissueOBO
def: "A thimble-shaped group of cells found at the tip of roots; it functions to protect the meristem." [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
synonym: "GRO:0005429" RELATED []
relationship: part_of BTO:0001191 ! root tip

[Term]
id: BTO:0000040
name: adenohypophysis
namespace: BrendaTissueOBO
def: "The anterior glandular lobe of the pituitary gland." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=adenohypophysis]
synonym: "anterior pituitary" RELATED []
synonym: "anterior pituitary gland" RELATED []
relationship: part_of BTO:0000496 ! anterior lobe

[Term]
id: BTO:0000041
name: medulla oblongata
namespace: BrendaTissueOBO
def: "The part of the vertebrate brain that is continuous posteriorly with the spinal cord and that contains the centers controlling involuntary vital functions." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=medulla+oblongata]
relationship: part_of BTO:0000758 ! myelencephalon

[Term]
id: BTO:0000042
name: animal
namespace: BrendaTissueOBO
def: "Any of a kingdom (Animalia) of living things including many-celled organisms and often many of the single-celled ones (as protozoans) that typically differ from plants in having cells without cellulose walls, in lacking chlorophyll and the capacity for photosynthesis, in requiring more complex food materials (as proteins), in being organized to a greater degree of complexity, and in having the capacity for spontaneous movement and rapid motor responses to stimulation." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=animal]
synonym: "animalia" RELATED []
synonym: "metazoa" RELATED []
is_a: BTO:0000000 ! brenda source tissue ontology

[Term]
id: BTO:0000043
name: cerebellar cortex
namespace: BrendaTissueOBO
def: "The superficial gray matter of the cerebellum. It consists of three layers, the stratum moleculare, stratum granulosum, and stratum purkinjense." [Dorlands Medical Dictionary:MerckSource]
synonym: "cortex cerebellaris" RELATED []
relationship: part_of BTO:0000232 ! cerebellum

[Term]
id: BTO:0000044
name: tear gland
namespace: BrendaTissueOBO
def: "An acinous gland that is about the size and shape of an almond, secretes tears, and is situated laterally and superiorly to the bulb of the eye in a shallow depression on the inner surface of the frontal bone." [Fast Health Medical Dictionary:http\://www.fasthealth.com/dictionary/]
synonym: "lacrimal gland" RELATED []
is_a: BTO:0000431 ! excretory gland
relationship: part_of BTO:0000439 ! eye

[Term]
id: BTO:0000045
name: adrenal cortex
namespace: BrendaTissueOBO
def: "The outer portion of the adrenal glands that produces several steroid hormones, including cortisol and aldosterone." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
synonym: "cortex glandulae suprarenalis" RELATED []
synonym: "suprarenal cortex" RELATED []
relationship: part_of BTO:0000047 ! adrenal gland

[Term]
id: BTO:0000046
name: Y-1 cell
namespace: BrendaTissueOBO
def: "Mouse adrenal cortex tumor. Mouse, LAF1 male; Tissue: adrenal cortex; Tumor: adrenal tumor." [HyperCLDB:http\://www.biotech.ist.unige.it/]
synonym: "Y1 cell" RELATED []
is_a: BTO:0000851 ! adrenal cortex cell line

[Term]
id: BTO:0000047
name: adrenal gland
namespace: BrendaTissueOBO
def: "Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=adrenal+gland]
synonym: "adrenal" RELATED []
synonym: "adrenal capsule" RELATED []
synonym: "atrabiliary capsule" RELATED []
synonym: "epinephros" RELATED []
synonym: "glandula suprarenalis" RELATED []
synonym: "suprarenal capsule" RELATED []
synonym: "suprarenal gland" RELATED []
is_a: BTO:0001488 ! endocrine gland
is_a: BTO:0001491 ! viscus

[Term]
id: BTO:0000048
name: zona glomerulosa
namespace: BrendaTissueOBO
def: "The outermost of the three layers of the adrenal cortex that consists of round masses of granular epithelial cells that stain deeply." [Fast Health Medical Dictionary:http\://www.fasthealth.com/dictionary/]
synonym: "glomerulosa" RELATED []
relationship: part_of BTO:0000045 ! adrenal cortex

[Term]
id: BTO:0000049
name: adrenal medulla
namespace: BrendaTissueOBO
def: "The inner, reddish-brown portion of the adrenal glands that synthesizes, stores, and releases epinephrine and norepinephrine." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
relationship: part_of BTO:0000047 ! adrenal gland

[Term]
id: BTO:0000050
name: zona fasciculata
namespace: BrendaTissueOBO
def: "The middle of the three layers of the adrenal cortex that consists of radially arranged columnar epithelial cells. " [Fast Health Medical Dictionary:http\://www.fasthealth.com/dictionary/]
relationship: part_of BTO:0000045 ! adrenal cortex

[Term]
id: BTO:0000051
name: tendon sheath
namespace: BrendaTissueOBO
def: "A synovial sheath covering a tendon (as in the hand or foot) . " [Fast Health Medical Dictionary:http\://www.fasthealth.com/dictionary/]
relationship: part_of BTO:0001356 ! tendon

[Term]
id: BTO:0000052
name: stoma
namespace: BrendaTissueOBO
def: "The epidermal complex consisting of two guard cells and the pore between them." [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
synonym: "GRO:0005350" RELATED []
synonym: "stomatal complex" RELATED []
relationship: part_of BTO:0000718 ! leaf epidermis

[Term]
id: BTO:0000053
name: albedo
namespace: BrendaTissueOBO
def: "The spongy white tissue on the inside of the rind of citrus fruit." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
relationship: part_of BTO:0000733 ! exocarp

[Term]
id: BTO:0000054
name: albumen gland
namespace: BrendaTissueOBO
def: "The posterior oviduct opens into the large white albumen gland which adds a layer of albumen to the zygote before it reaches the egg capsule gland." [Invertebrate Anatomy OnLine \, Ilyanassa obsoleta:http\://www.lander.edu/rsfox/310ilyanassaLab.html]
is_a: BTO:0000254 ! female reproductive gland
relationship: REL BTO:0000369 ! egg

[Term]
id: BTO:0000055
name: pars recta
namespace: BrendaTissueOBO
def: "Proximal straight tubule: part of the descending limb of the renal tubule, extending from the proximal convoluted tubule to the thin tubule." [Dorlands Medical Dictionary:MerckSource]
synonym: "pars recta tubuli renalis" RELATED []
relationship: part_of BTO:0001498 ! renal proximal tubule

[Term]
id: BTO:0000056
name: zona reticulata
namespace: BrendaTissueOBO
def: "The innermost of the three layers of the adrenal cortex that consists of irregularly arranged cylindrical masses of epithelial cells. " [Fast Health Medical Dictionary:http\://www.fasthealth.com/dictionary/]
relationship: part_of BTO:0000045 ! adrenal cortex

[Term]
id: BTO:0000057
name: aleurone layer
namespace: BrendaTissueOBO
def: "A group of cells rich in protein granules and located as the outer layer of the endosperm of many grain seeds." [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
synonym: "aleurone" RELATED []
synonym: "GRO:0005360" RELATED []
is_a: BTO:0000390 ! endosperm

[Term]
id: BTO:0000058
name: alimentary canal
namespace: BrendaTissueOBO
def: "The mucous membrane-lined tube of the digestive system through which food passes, in which digestion takes place, and from which wastes are eliminated. It extends from the mouth to the anus and includes the pharynx, esophagus, stomach, and intestines." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
synonym: "digestive canal" RELATED []
synonym: "digestive tract" RELATED []
synonym: "digestive tube" RELATED []
is_a: BTO:0001491 ! viscus

[Term]
id: BTO:0000059
name: renal epithelium
namespace: BrendaTissueOBO
synonym: "kidney epithelium" RELATED []
is_a: BTO:0000416 ! epithelium
relationship: part_of BTO:0000671 ! kidney

[Term]
id: BTO:0000060
name: alveolus
namespace: BrendaTissueOBO
def: "A tiny, thin-walled, capillary-rich sac in the lungs where the exchange of oxygen and carbon dioxide takes place." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
synonym: "air sac" RELATED []
synonym: "alveoli" RELATED []
relationship: part_of BTO:0000061 ! alveolar sac

[Term]
id: BTO:0000061
name: alveolar sac
namespace: BrendaTissueOBO
def: "Each large alveolar sac is like a grape cluster which contains ten or more alveoli." [The Probert Encyclopaedia \, Medicine:http\://www.probertencyclopaedia.com/E1B.HTM]
relationship: part_of BTO:0000136 ! bronchoalveolar system

[Term]
id: BTO:0000062
name: amastigote
namespace: BrendaTissueOBO
def: "Any of the bodies representing the morphologic (leishmanial) stage in the life cycle of all trypanosomatid protozoa resembling the typical adult form of members of the genus Leishmania, in which the oval or round cell has a nucleus, kinetoplast, and basal body but lacks a free-flowing flagellum, the flagellum being either very short or entirely absent." [Dorlands Medical Dictionary:MerckSource]
synonym: "aflagellate form" RELATED []
synonym: "Leishman-Donovan body" RELATED []
synonym: "leishmanial form" RELATED []
synonym: "micromastigote" RELATED []
synonym: "spheromastigote" RELATED []
is_a: BTO:0000092 ! trypanosome

[Term]
id: BTO:0000063
name: culture condition:ammonium malate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000064
name: amniochorion
namespace: BrendaTissueOBO
def: "Pertaining to the amnion and chorion." [Dorlands Medical Dictionary:MerckMedicus]
synonym: "Chorioamnion" RELATED []
is_a: BTO:0000473 ! fetal membrane

[Term]
id: BTO:0000065
name: amnion
namespace: BrendaTissueOBO
def: "A thin, tough, membranous sac that encloses the embryo or fetus of a mammal, bird, or reptile. It is filled with a serous fluid in which the embryo is suspended." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
is_a: BTO:0000473 ! fetal membrane

[Term]
id: BTO:0000066
name: amniocyte
namespace: BrendaTissueOBO
def: "A cell of fetal origin obtained in an amniotic fluid specimen." [Dorlands Medical Dictionary:MerckMedicus]
synonym: "amniotic cell" RELATED []
relationship: part_of BTO:0000065 ! amnion

[Term]
id: BTO:0000067
name: kidney cell line
namespace: BrendaTissueOBO
relationship: DRV BTO:0000671 ! kidney

[Term]
id: BTO:0000068
name: amniotic fluid
namespace: BrendaTissueOBO
def: "Fluid within the amniotic cavity produced by the amnion during the early embryonic period, and later by the lungs and kidneys; at first crystal clear, it later becomes cloudy. It protects the embryo and fetus from injury. The amount at term normally varies from 500 to 1500 mL." [Dorlands Medical Dictionary:MerckSource]
synonym: "acqua amnii" RELATED []
synonym: "liquor amnii" RELATED []
relationship: REL BTO:0000025 ! amniotic cavity

[Term]
id: BTO:0000069
name: WISH cell
namespace: BrendaTissueOBO
def: "Human amnion cell line with HeLa markers." [ATCC American Cell Type Culture Collection:http\://www.lgcstandards-atcc.org/]
is_a: BTO:0000110 ! amniotic cell line

[Term]
id: BTO:0000070
name: amoeba
namespace: BrendaTissueOBO
def: "Any of a large genus (Amoeba) of naked rhizopod protozoans with lobed and never anastomosing pseudopodia, without permanent organelles or supporting structures, and of wide distribution in fresh and salt water and moist terrestrial environments." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=amoeba]
is_a: BTO:0000284 ! organism form

[Term]
id: BTO:0000071
name: amoebocyte
namespace: BrendaTissueOBO
def: "A cell (as a phagocyte) having amoeboid form or movements." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=amoebocyte]
is_a: BTO:0001044 ! phagocyte
is_a: BTO:0002856 ! coelomocyte

[Term]
id: BTO:0000072
name: carpel
namespace: BrendaTissueOBO
def: "The female reproductive part of a flower, consisting of stigma, style, and ovary." [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
synonym: "GRO:0005441" RELATED []
synonym: "pistil" RELATED []
relationship: part_of BTO:0001733 ! gynoecium

[Term]
id: BTO:0000073
name: culture condition:aniline-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000074
name: antenna
namespace: BrendaTissueOBO
def: "One of a pair of slender movable segmented sensory organs on the head of insects, myriapods, and crustaceans." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=antenna]
is_a: BTO:0000202 ! sense organ
relationship: part_of BTO:0000282 ! head

[Term]
id: BTO:0000075
name: antennal gland
namespace: BrendaTissueOBO
def: "Excretory gland situated in the basal article of the antennal peduncle." [Crustacea Glossary:http\://atiniui.nhm.org/glossary/index.html?terms=Antennal+gland]
is_a: BTO:0000431 ! excretory gland
relationship: part_of BTO:0000074 ! antenna

[Term]
id: BTO:0000076
name: anterior midgut
namespace: BrendaTissueOBO
relationship: part_of BTO:0000863 ! midgut

[Term]
id: BTO:0000077
name: posterior midgut
namespace: BrendaTissueOBO
relationship: part_of BTO:0000863 ! midgut

[Term]
id: BTO:0000078
name: microglia
namespace: BrendaTissueOBO
alt_id: BTO:0000103
def: "MERGED DEFINITION:\nTARGET DEFINITION: The small, non-neural, interstitial cells of mesodermal origin that form part of the supporting structure of the central nervous system. They are of various forms and may have slender branched processes. They are migratory and act as phagocytes to waste products of nerve tissue. \n--------------------\nSOURCE DEFINITION: One of the small interstitial phagocytic cells of the microglia." [Dorlands Medical Dictionary:MerckSource]
synonym: "Hortega cell" RELATED []
synonym: "microglial cell" EXACT []
synonym: "microgliocyte" RELATED []
is_a: BTO:0000524 ! glia
is_a: BTO:0000801 ! macrophage

[Term]
id: BTO:0000079
name: anther
namespace: BrendaTissueOBO
def: "The male reproductive organ enclosing and containing the pollen grains. " [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
synonym: "GRO:0005596" RELATED []
relationship: part_of BTO:0001559 ! stamen

[Term]
id: BTO:0000080
name: male reproductive gland
namespace: BrendaTissueOBO
is_a: BTO:0001488 ! endocrine gland
relationship: part_of BTO:0000082 ! male reproductive system

[Term]
id: BTO:0000081
name: reproductive system
namespace: BrendaTissueOBO
def: "Reproductive: of, relating to, or capable of reproduction." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=reproductive]
relationship: part_of BTO:0001489 ! whole body

[Term]
id: BTO:0000082
name: male reproductive system
namespace: BrendaTissueOBO
def: "The reproductive system in men includes the prostate, the testes, and the penis. " [Cancer.gov Dictionary:http\://www.nci.nih.gov/dictionary]
is_a: BTO:0000081 ! reproductive system

[Term]
id: BTO:0000083
name: female reproductive system
namespace: BrendaTissueOBO
def: "The reproductive system in women includes the ovaries, the fallopian tubes, the uterus (womb), the cervix, and the vagina (birth canal)." [Cancer.gov Dictionary:http\://www.nci.nih.gov/dictionary]
synonym: "gynaecological tissue" RELATED []
is_a: BTO:0000081 ! reproductive system

[Term]
id: BTO:0000084
name: vermiform appendix
namespace: BrendaTissueOBO
def: "A narrow blind tube usually about three or four inches (7.6 to 10.2 centimeters) long that extends from the cecum in the lower right-hand part of the abdomen, has much lymphoid wall tissue, normally communicates with the cavity of the cecum, and represents an atrophied terminal part of the cecum. " [Fast Health Medical Dictionary:http\://www.fasthealth.com/dictionary/]
relationship: part_of BTO:0000166 ! cecum

[Term]
id: BTO:0000085
name: appressorium
namespace: BrendaTissueOBO
def: "The flattened thickened tip of a hyphal branch by which some parasitic fungi are attached to their host." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=appressorium]
relationship: part_of BTO:0000612 ! hypha

[Term]
id: BTO:0000086
name: culture condition:arabinose-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000087
name: arterial smooth muscle
namespace: BrendaTissueOBO
synonym: "arterial smooth muscle cell" RELATED []
is_a: BTO:0001260 ! smooth muscle
relationship: part_of BTO:0000573 ! artery

[Term]
id: BTO:0000088
name: cardiovascular system
namespace: BrendaTissueOBO
def: "The system of heart and blood vessels." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cardiovascular]
relationship: part_of BTO:0001489 ! whole body

[Term]
id: BTO:0000089
name: blood
namespace: BrendaTissueOBO
def: "1: The fluid that circulates in the heart, arteries, capillaries, and veins of a vertebrate animal carrying nourishment and oxygen to and bringing away waste products from all parts of the body.\n2: A comparable fluid of an invertebrate." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=blood]
relationship: part_of BTO:0000570 ! hematopoietic system

[Term]
id: BTO:0000090
name: ascidian
namespace: BrendaTissueOBO
def: "Any of a class (Ascidiacea) of solitary or colonial sessile tunicates that have an oral and an atrial siphon." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=ascidian]
synonym: "sea squirt" RELATED []
is_a: BTO:0000284 ! organism form

[Term]
id: BTO:0000091
name: ascites
namespace: BrendaTissueOBO
def: "Accumulation of serous fluid in the spaces between tissues and organs in the cavity of the abdomen." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=ascites]
synonym: "ascites fluid" RELATED []
relationship: part_of BTO:0000020 ! abdomen

[Term]
id: BTO:0000092
name: trypanosome
namespace: BrendaTissueOBO
def: "Any of a genus (Trypanosoma) of parasitic flagellate protozoans that infest the blood of various vertebrates including humans, are usually transmitted by the bite of an insect, and include some that cause serious disease (as sleeping sickness)." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=trypanosome]
is_a: BTO:0000464 ! flagellate

[Term]
id: BTO:0000093
name: MCF-7 cell
namespace: BrendaTissueOBO
def: "Human breast adenocarcinoma, established from the pleural effusion of a 69-year-old caucasian woman with metastatic mammary carcinoma (after radio- and hormone therapy) in 1970; cells were described of being positive for cytoplasmic estrogen receptors and  having the capability to form domes." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
synonym: "MCF7 cell" RELATED []
is_a: BTO:0001912 ! breast adenocarcinoma cell line

[Term]
id: BTO:0000094
name: ascites tumor cell
namespace: BrendaTissueOBO
relationship: DRV BTO:0000091 ! ascites

[Term]
id: BTO:0000095
name: F9 cell
namespace: BrendaTissueOBO
def: "Mouse embryonal carcinoma, initiated from a testicular teratocarcinoma of a strain 129 mouse." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
synonym: "F9 EC cell" RELATED []
synonym: "F9 embryonal carcinoma cell" RELATED []
synonym: "F9-EC cell" RELATED []
is_a: BTO:0000306 ! teratocarcinoma cell line
is_a: BTO:0001437 ! embryonic carcinoma cell line

[Term]
id: BTO:0000096
name: urinary bladder cell line
namespace: BrendaTissueOBO
relationship: DRV BTO:0001418 ! urinary bladder

[Term]
id: BTO:0000097
name: ascospore
namespace: BrendaTissueOBO
def: "Any of the spores contained in an ascus." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=ascospore]
synonym: "FAO:0000016" RELATED []
is_a: BTO:0001171 ! spore
relationship: part_of BTO:0002161 ! ascocarp

[Term]
id: BTO:0000098
name: astroblast
namespace: BrendaTissueOBO
def: "An embryonic astrocyte." [The Dictionary of Cell and Molecular Biology:Third Edition]
is_a: BTO:0000930 ! neuroblast

[Term]
id: BTO:0000099
name: astrocyte
namespace: BrendaTissueOBO
def: "A star-shaped cell, especially a neuroglial cell of nervous tissue." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
is_a: BTO:0000771 ! macroglia
relationship: DRV BTO:0000098 ! astroblast
relationship: part_of BTO:0003852 ! astroglia

[Term]
id: BTO:0000100
name: astrocytoma cell
namespace: BrendaTissueOBO
def: "A tumor cell composed of astrocytes; it is the most common type of primary brain tumor and is also found throughout the central nervous system. One classification groups astrocytomas according to their histologic appearance and distinguishes pilocytic, protoplasmic, gemistocytic, and fibrillary types. Another classification groups them in order of increasing malignancy as Grade I, Grade II, Grade III, and Grade IV types." [Dorlands Medical Dictionary:MerckSource]
synonym: "astrocytic glioma cell" RELATED []
is_a: BTO:0000526 ! glioma cell
relationship: DRV BTO:0000099 ! astrocyte

[Term]
id: BTO:0000101
name: astrocytoma cell line
namespace: BrendaTissueOBO
is_a: BTO:0000690 ! brain cancer cell line
relationship: DRV BTO:0000100 ! astrocytoma cell
relationship: DRV BTO:0001531 ! glial cell line

[Term]
id: BTO:0000102
name: blood clot
namespace: BrendaTissueOBO
def: "A semisolid gelatinous mass of coagulated blood that consists of red blood cells, white blood cells, and platelets entrapped in a fibrin network." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
synonym: "thrombus" RELATED []
relationship: DRV BTO:0000089 ! blood

[Term]
id: BTO:0000104
name: lymphoma cell line
namespace: BrendaTissueOBO
def: "Lymphoma means any neoplastic disorder of the lymphoid tissue." [Dorlands Medical Dictionary:MerckSource]
synonym: "lymphadenoma cell line" RELATED []
relationship: DRV BTO:0000785 ! lymphoma cell
relationship: DRV BTO:0001586 ! lymphoid cell line

[Term]
id: BTO:0000105
name: upper epidermis
namespace: BrendaTissueOBO
def: "The epidermal layer directed towards the axis." [Gramene DB:http\://dev.gramene.org/db/ontology/search/]
synonym: "adaxial epidermis" RELATED []
synonym: "GRO:0005683" RELATED []
is_a: BTO:0000718 ! leaf epidermis

[Term]
id: BTO:0000106
name: cranial ganglion
namespace: BrendaTissueOBO
is_a: BTO:0000497 ! ganglion

[Term]
id: BTO:0000107
name: B95-8 cell
namespace: BrendaTissueOBO
def: "Marmoset monkey lymphocytes, established from peripheral blood lymphocytes of a marmoset monkey (saguinus oedipus); cells were described to release high titers of Epstein-Barr virus (EBV) providing a source for transformation of B cells and establishment of continuous cell lines; this cell line has been assigned by the ZKBS (German Central Commission for Biological Safety) to risk group 2." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
is_a: BTO:0001522 ! B-lymphocyte cell line

[Term]
id: BTO:0000108
name: olfactory epithelium
namespace: BrendaTissueOBO
def: "Pseudostratified epithelium lining the olfactory region of the nasal cavity, and containing the receptors for the sense of smell." [Dorlands Medical Dictionary:MerckSource]
synonym: "nasal cavity olfactory epithelium" RELATED []
synonym: "nasal epithelium" RELATED []
synonym: "olfactory mucosa" RELATED []
is_a: BTO:0000912 ! nasal mucosa

[Term]
id: BTO:0000109
name: bacteroid
namespace: BrendaTissueOBO
def: "An irregularly shaped bacterium (as a rhizobium) found especially in root nodules of legumes." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=bacteroid]
is_a: BTO:0000284 ! organism form
relationship: REL BTO:0001190 ! root nodule

[Term]
id: BTO:0000110
name: amniotic cell line
namespace: BrendaTissueOBO
relationship: DRV BTO:0000065 ! amnion

[Term]
id: BTO:0000111
name: BALB/3T12-3 cell
namespace: BrendaTissueOBO
def: "Derived from a 14-17 day old BALB/c mouse embryo. The cells are tumorigenic, are insensitive to contact inhibition and are susceptible to transformation with SV40 virus." [HyperCLDB:http\://www.biotech.ist.unige.it/]
synonym: "3T12 cell" RELATED []
is_a: BTO:0001958 ! embryonic fibroblast cell line

[Term]
id: BTO:0000112
name: sieve cell
namespace: BrendaTissueOBO
def: "The phloem conducting cell in nonangiosperms; they are long and tapered with small sieve areas over much of their surfaces. " [Botany - An Introduction to Plant Biology \, Third Edition:http\://biology.jbpub.com/Botany/interactive_glossary_showterm.cfm?term=sieve]
relationship: part_of BTO:0001058 ! phloem

[Term]
id: BTO:0000113
name: cervical ganglion
namespace: BrendaTissueOBO
def: "Any of three sympathetic ganglia on each side of the neck.  " [Fast Health Medical Dictionary:http\://www.fasthealth.com/dictionary/]
is_a: BTO:0001333 ! sympathetic ganglion

[Term]
id: BTO:0000114
name: basidiocarp
namespace: BrendaTissueOBO
def: "The large fruiting body characteristic of the majority of fungi of the subphylum Basidiomycotina; it is composed of masses of intertwined hyphal elements and produces basidia. Mushrooms and toadstools are common examples." [Dorlands Medical Dictionary:MerckSource]
synonym: "FAO:0000012" RELATED []
is_a: BTO:0000487 ! fruitbody

[Term]
id: BTO:0000115
name: BC3H1 cell
namespace: BrendaTissueOBO
def: "Mouse brain tumor cell line. Established from a mouse tumor induced by nitrosoethylurea with properties characteristic of muscle; cells were described to synthesize adenylate and creatine phosphokinases." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
is_a: BTO:0000690 ! brain cancer cell line

[Term]
id: BTO:0000116
name: plant epidermis
namespace: BrendaTissueOBO
def: "A thin surface layer of tissue in higher plants formed by growth of a primary meristem." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=epidermis]
relationship: part_of BTO:0001461 ! whole plant

[Term]
id: BTO:0000117
name: culture condition:benzoate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000118
name: culture condition:benzoylformate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000119
name: berry
namespace: BrendaTissueOBO
def: "A simple fruit (as a currant, grape, tomato, or banana) with a pulpy or fleshy pericarp." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=berry]
is_a: BTO:0000486 ! fruit

[Term]
id: BTO:0000120
name: BHK-21 cell
namespace: BrendaTissueOBO
def: "Syrian hamster kidney BHK-21 is a subclone (clone 13) of the parental line established from the kidneys of five unsexed, one-day-old hamsters in 1961; cells can be used for virus replication studies." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
synonym: "baby hamster kidney cell" RELATED []
synonym: "BHK 21 cell" RELATED []
synonym: "BHK-21/C13 cell" RELATED []
is_a: BTO:0001131 ! BHK cell

[Term]
id: BTO:0000121
name: bile
namespace: BrendaTissueOBO
def: "A fluid secreted by the liver and poured into the small intestine via the bile ducts. Important constituents are conjugated bile salts, cholesterol, phospholipid, bilirubin diglucuronide, and electrolytes. Bile is alkaline due to its bicarbonate content, is golden brown to greenish yellow in color, and has a bitter taste. Bile secreted by the liver is concentrated in the gallbladder." [Dorlands Medical Dictionary:MerckSource]
synonym: "fel" RELATED []
synonym: "gall" RELATED []
is_a: BTO:0000346 ! digestive juice
relationship: DRV BTO:0000759 ! liver
relationship: REL BTO:0000493 ! gall bladder

[Term]
id: BTO:0000122
name: bile duct
namespace: BrendaTissueOBO
def: "Any of the ducts that convey bile in and from the liver." [Dorlands Medical Dictionary:MerckSource]
synonym: "biliary duct" RELATED []
synonym: "gall duct" RELATED []
relationship: part_of BTO:0000759 ! liver

[Term]
id: BTO:0000123
name: bladder
namespace: BrendaTissueOBO
def: "A membranous sac in animals that serves as the receptacle of a liquid or contains gas." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=bladder]
is_a: BTO:0001491 ! viscus

[Term]
id: BTO:0000124
name: microspore
namespace: BrendaTissueOBO
def: "Haploid cells produced by meiosis in the anthers of angiosperms; four microspores are produced from a single microsporocyte." [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
relationship: DRV BTO:0000540 ! pollen mother cell

[Term]
id: BTO:0000125
name: blast cell
namespace: BrendaTissueOBO
def: "In the monophyletic theory, the least differentiated, totipotential blood cell without commitment as to its particular series, from which all blood cells are derived, preceding a stem cell. " [Dorlands Medical Dictionary:MerckSource]
synonym: "blast" RELATED []
synonym: "hematoblast" RELATED []
synonym: "hematocytoblast" RELATED []
synonym: "hemocytoblast" RELATED []
relationship: part_of BTO:0000089 ! blood

[Term]
id: BTO:0000126
name: blastoderm
namespace: BrendaTissueOBO
def: "The mass of cells produced by cleavage of a fertilized ovum, forming the hollow sphere of the blastula, or the cellular cap above a floor of segmented yolk in the discoblastula of telolecithal eggs. " [Dorlands Medical Dictionary:MerckSource]
synonym: "germinal membrane" RELATED []
synonym: "membrana germinativa" RELATED []
relationship: part_of BTO:0000128 ! blastula
relationship: part_of BTO:0000535 ! germ cell

[Term]
id: BTO:0000127
name: blastospore
namespace: BrendaTissueOBO
def: "A fungal spore produced by budding." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=blastospore]
is_a: BTO:0001171 ! spore

[Term]
id: BTO:0000128
name: blastula
namespace: BrendaTissueOBO
def: "The usually spherical structure produced by cleavage of a zygote, consisting of a single layer of cells (blastoderm) surrounding a fluid-filled cavity (blastocoele)." [Dorlands Medical Dictionary:MerckSource]
synonym: "blastosphere" RELATED []
relationship: DRV BTO:0001508 ! morula

[Term]
id: BTO:0000129
name: basophil
namespace: BrendaTissueOBO
def: "Mammalian granulocyte with large heterochromatic basophilic granules that contain histamine bound to a protein and heparin-like mucopolysaccharide matrix. They are not phagocytic. Very similar to mast cells though it is not clear whether they have common lineage." [The Dictionary of Cell and Molecular Biology:Third Edition]
synonym: "basophil granulocyte" RELATED []
is_a: BTO:0000539 ! granulocyte

[Term]
id: BTO:0000130
name: neutrophil
namespace: BrendaTissueOBO
def: "A granulocyte that is the chief phagocytic white blood cell of the blood." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=neutrophil]
synonym: "neutrophil granulocyte" RELATED []
is_a: BTO:0000539 ! granulocyte
is_a: BTO:0001044 ! phagocyte

[Term]
id: BTO:0000131
name: blood plasma
namespace: BrendaTissueOBO
def: "The fluid portion of the blood in which the particulate components are suspended." [Dorlands Medical Dictionary:MerckSource]
synonym: "plasma" RELATED []
relationship: part_of BTO:0000089 ! blood

[Term]
id: BTO:0000132
name: blood platelet
namespace: BrendaTissueOBO
def: "A minute, nonnucleated, disklike cytoplasmic body found in the blood plasma of mammals that is derived from a megakaryocyte and functions to promote blood clotting" [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
synonym: "platelet" RELATED []
synonym: "thrombocyte" RELATED []
relationship: DRV BTO:0000843 ! megakaryocyte
relationship: part_of BTO:0000131 ! blood plasma

[Term]
id: BTO:0000133
name: blood serum
namespace: BrendaTissueOBO
def: "The cell-free portion of the blood from which the fibrinogen has been separated in the process of clotting." [Dorlands Medical Dictionary:MerckSource]
is_a: BTO:0001239 ! serum
relationship: part_of BTO:0000131 ! blood plasma

[Term]
id: BTO:0000134
name: bloodstream form
namespace: BrendaTissueOBO
def: "When living in the mammalian bloodstream T. brucei has neither a functional Krebs cycle nor oxidative phosphorylation nor does it store any carbohydrates. In the bloodstream form. Its metabolism is restricted to the glycolytic pathway alone. " [PMID:9013556]
is_a: BTO:0000092 ! trypanosome

[Term]
id: BTO:0000135
name: aorta
namespace: BrendaTissueOBO
def: "The great arterial trunk that carries blood from the heart to be distributed by branch arteries through the body." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=aorta]
relationship: part_of BTO:0000562 ! heart

[Term]
id: BTO:0000136
name: bronchoalveolar system
namespace: BrendaTissueOBO
def: "System pertaining to a bronchus and alveoli." [Dorlands Medical Dictionary:MerckSource]
relationship: part_of BTO:0000763 ! lung

[Term]
id: BTO:0000137
name: pulmonary artery endothelium
namespace: BrendaTissueOBO
is_a: BTO:0000393 ! endothelium
relationship: part_of BTO:0000778 ! pulmonary artery

[Term]
id: BTO:0000138
name: midbrain
namespace: BrendaTissueOBO
def: "The middle of the three primary divisions of the developing vertebrate brain or the corresponding part of the adult brain." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=midbrain]
synonym: "mesencephalon" RELATED []
relationship: part_of BTO:0000146 ! brain stem

[Term]
id: BTO:0000139
name: body wall
namespace: BrendaTissueOBO
def: "The portion of an animal body that consists of ectoderm and mesoderm, forms the external body surface, and encloses the body cavity." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
relationship: part_of BTO:0001489 ! whole body

[Term]
id: BTO:0000140
name: bone
namespace: BrendaTissueOBO
def: "The hard form of connective tissue that constitutes the majority of the skeleton of most vertebrates; it consists of an organic component (the cells and matrix) and an inorganic, or mineral, component; the matrix contains a framework of collagenous fibers and is impregnated with the mineral component, chiefly calcium phosphate (85 per cent) and calcium carbonate (10 per cent), which imparts the quality of rigidity to bone. " [Dorlands Medical Dictionary:MerckSource]
synonym: "osseous tissue" RELATED []
is_a: BTO:0000421 ! connective tissue
relationship: part_of BTO:0001486 ! skeletal system

[Term]
id: BTO:0000141
name: bone marrow
namespace: BrendaTissueOBO
def: "The soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
synonym: "bone marrow cell" RELATED []
synonym: "medulla ossium" RELATED []
relationship: part_of BTO:0001486 ! skeletal system

[Term]
id: BTO:0000142
name: brain
namespace: BrendaTissueOBO
def: "1: The portion of the vertebrate central nervous system that constitutes the organ of thought and neural coordination, includes all the higher nervous centers receiving stimuli from the sense organs and interpreting and correlating them to formulate the motor impulses, is made up of neurons and supporting and nutritive structures, is enclosed within the skull, and is continuous with the spinal cord through the foramen magnum.\n2: A nervous center in invertebrates comparable in position and function to the vertebrate brain." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=brain]
relationship: part_of BTO:0000227 ! central nervous system
relationship: part_of BTO:0000282 ! head

[Term]
id: BTO:0000143
name: substantia nigra
namespace: BrendaTissueOBO
def: "The substantia nigra is located in the mesencephalon (mid brain) region of the brain. It is part of the basal ganglia." [Anatomy of the Brain:http\://biology.about.com/library/organs/brain/blsubstantianigra.htm]
relationship: part_of BTO:0000138 ! midbrain
relationship: part_of BTO:0000235 ! basal ganglion

[Term]
id: BTO:0000144
name: meninx
namespace: BrendaTissueOBO
def: "Any of the three membranes that envelop the brain and spinal cord." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=meninx]
synonym: "meninges" RELATED []
relationship: part_of BTO:0000142 ! brain
relationship: part_of BTO:0000282 ! head
relationship: part_of BTO:0001279 ! spinal cord

[Term]
id: BTO:0000145
name: brain myelin
namespace: BrendaTissueOBO
relationship: part_of BTO:0000236 ! cerebral white matter

[Term]
id: BTO:0000146
name: brain stem
namespace: BrendaTissueOBO
def: "The part of the brain composed of the mesencephalon, pons, and medulla oblongata and connecting the spinal cord with the forebrain and cerebrum." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=brain+stem]
synonym: "brainstem" RELATED []
synonym: "truncus encephalicus" RELATED []
relationship: part_of BTO:0000142 ! brain

[Term]
id: BTO:0000147
name: microgametophyte
namespace: BrendaTissueOBO
def: "A plant body or cell lineage, formed by vegetative growth of the microspore, that produces the male gametes of a heterosporous plant. " [Jim Croft`s Flora of Australia:http\://www.cartage.org.lb/en/themes/Reference/dictionary/Biologie/M/182.html]
synonym: "GRO:0000162" RELATED []
synonym: "male gametophyte" RELATED []
is_a: BTO:0000495 ! gametophyte

[Term]
id: BTO:0000148
name: branch
namespace: BrendaTissueOBO
def: "A natural subdivision of a plant stem; especially: a secondary shoot or stem (as a bough) arising from a main axis (as of a tree)." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=branch]
synonym: "axillary shoot" RELATED []
synonym: "GRO:0005304" RELATED []
synonym: "lateral shoot" RELATED []
relationship: part_of BTO:0001300 ! stem

[Term]
id: BTO:0000149
name: breast
namespace: BrendaTissueOBO
def: "1: The fore or ventral part of the body between the neck and the abdomen.\n2: Either of the pair of mammary glands extending from the front of the chest in pubescent and adult human females and some other mammals." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=breast]
is_a: BTO:0000254 ! female reproductive gland
is_a: BTO:0000431 ! excretory gland
relationship: part_of BTO:0001368 ! thorax

[Term]
id: BTO:0000150
name: breast cancer cell
namespace: BrendaTissueOBO
alt_id: BTO:0001005
def: "Breast cancer is an uncontrolled growth of malignant breast tissue. Most breast cancers begin in the milk ducts: these are called intraductal cancers. A few, like lobular cancer, start in the milk sacs or lobes." [Online Medical Dictionary:http\://cancerweb.ncl.ac.uk/]
synonym: "breast adenocarcinoma cell" RELATED []
synonym: "breast carcinoma cell" RELATED []
synonym: "mammary carcinoma cell" RELATED []
synonym: "mammary tumor cell" RELATED []
is_a: BTO:0000604 ! adenocarcinoma cell
relationship: DRV BTO:0000149 ! breast

[Term]
id: BTO:0000151
name: extensor
namespace: BrendaTissueOBO
def: "A muscle that, upon contraction, tends to straighten a limb. The antagonist of a flexor muscle." [Illustrated Encyclopedia of Human Anatomic Variation:Part I Muscular System http\://www.vh.org/adult/provider/anatomy/AnatomicVariants/MuscularSystem/Terminology.html]
is_a: BTO:0001103 ! skeletal muscle

[Term]
id: BTO:0000152
name: infected cell
namespace: BrendaTissueOBO
is_a: BTO:0000214 ! cell culture

[Term]
id: BTO:0000153
name: Walker carcinoma 256 cell
namespace: BrendaTissueOBO
def: "A cell of a transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. " [Online Medical Dictionary:http\://cancerweb.ncl.ac.uk/]
synonym: "Walker carcinosarcoma 256 cell" RELATED []
is_a: BTO:0000150 ! breast cancer cell
is_a: BTO:0001207 ! sarcoma cell

[Term]
id: BTO:0000154
name: BRL-3A cell
namespace: BrendaTissueOBO
def: "Rat liver cell line. Established from the buffalo strain of rattus norvegicus." [ATCC American Cell Type Culture Collection:http\://www.lgcstandards-atcc.org/]
synonym: "BRL3A cell" RELATED []
relationship: DRV BTO:0001933 ! BRL cell

[Term]
id: BTO:0000155
name: bronchoalveolar lavage
namespace: BrendaTissueOBO
def: "A technique by which cells and fluid from bronchioles and lung alveoli are removed for diagnosis of disease or evaluation of treatment. A bronchoscope is wedged into a bronchus and sterile saline is pumped in and then removed along with the fluid and cells to be analyzed." [Dorlands Medical Dictionary:MerckSource]
synonym: "BAL cell" RELATED []
synonym: "bronchoalveolar lavage fluid" RELATED []
relationship: REL BTO:0000136 ! bronchoalveolar system

[Term]
id: BTO:0000156
name: brown adipose tissue
namespace: BrendaTissueOBO
def: "A mammalian heat-producing tissue occurring especially in human newborns and in hibernators." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=brown+fat]
synonym: "brown fat" RELATED []
is_a: BTO:0001487 ! adipose tissue

[Term]
id: BTO:0000157
name: aorta thoracica
namespace: BrendaTissueOBO
def: "Thoracic part of aorta: the proximal portion of the descending aorta, which proceeds from the arch of the aorta and gives rise to the bronchial, esophageal, pericardiac, and mediastinal branches, and the superior phrenic, posterior intercostal III to XI, and subcostal arteries; it is continuous through the diaphragm with the abdominal aorta. " [Dorlands Medical Dictionary:MerckSource]
synonym: "aorta thoracalis" RELATED []
synonym: "pars thoracica aortae" RELATED []
synonym: "thoracic aorta" RELATED []
is_a: BTO:0000135 ! aorta

[Term]
id: BTO:0000158
name: plant bud
namespace: BrendaTissueOBO
def: "A small lateral or terminal protuberance on the stem of a plant that may develop into a flower, leaf, or shoot." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=bud]
synonym: "bud" RELATED []
relationship: part_of BTO:0001300 ! stem

[Term]
id: BTO:0000159
name: bulb
namespace: BrendaTissueOBO
def: "A resting stage of a plant (as the lily, onion, hyacinth, or tulip) that is usually formed underground and consists of a short stem base bearing one or more buds enclosed in overlapping membranous or fleshy leaves." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=bulb]
is_a: BTO:0000720 ! plant form

[Term]
id: BTO:0000160
name: bundle sheath
namespace: BrendaTissueOBO
def: "Sheath of parenchyma or sclerenchyma cells surrounding the vascular bundles in leaves." [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
synonym: "GRO:0005726" RELATED []
relationship: part_of BTO:0000713 ! leaf

[Term]
id: BTO:0000161
name: lung fibroblast cell line
namespace: BrendaTissueOBO
is_a: BTO:0000353 ! lung cell line
is_a: BTO:0000453 ! fibroblast cell line
relationship: DRV BTO:0000764 ! lung fibroblast

[Term]
id: BTO:0000162
name: culture condition:butyrate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000163
name: corolla
namespace: BrendaTissueOBO
def: "Collective term for the petals of a flower." [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
synonym: "GRO:0005654" RELATED []
relationship: part_of BTO:0001727 ! perianth

[Term]
id: BTO:0000164
name: Burkitt lymphoma cell
namespace: BrendaTissueOBO
def: "Malignant tumour cell of lymphoblasts derived from B-lymphocytes. Most commonly affects children in tropical Africa: both Epstein-Barr virus and immunosuppression due to malarial infection are involved." [The Dictionary of Cell and Molecular Biology:Third Edition]
synonym: "African lymphoma cell" RELATED []
synonym: "Burkitt's lymphoma cell" RELATED []
is_a: BTO:0000785 ! lymphoma cell

[Term]
id: BTO:0000165
name: C2C12 cell
namespace: BrendaTissueOBO
def: "This is a subclone (produced by H. Blau, et al) of the mouse myoblast cell line established by D. Yaffe and O. Saxel. The C2C12 cell line differentiates rapidly, forming contractile myotubes and producing characteristic muscle proteins. Treatment with bone morphogenic protein 2 (BMP-2) cause a shift in the differentiation pathway from myoblastic to osteoblastic. " [ATCC American Cell Type Culture Collection:http\://www.lgcstandards-atcc.org/]
is_a: BTO:0000256 ! myoblast cell line

[Term]
id: BTO:0000166
name: cecum
namespace: BrendaTissueOBO
def: "The first part of the large intestine, forming a dilated pouch into which open the ileum, colon, and appendix vermiformis." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
synonym: "blind intestine" RELATED []
synonym: "blindgut" RELATED []
synonym: "caecum" RELATED []
synonym: "intestinum caecum" RELATED []
relationship: part_of BTO:0000706 ! large intestine
relationship: part_of BTO:0002273 ! ileocecum

[Term]
id: BTO:0000167
name: adenocarcinoma cell line
namespace: BrendaTissueOBO
is_a: BTO:0000297 ! carcinoma cell line
relationship: DRV BTO:0000604 ! adenocarcinoma cell

[Term]
id: BTO:0000168
name: carotid artery
namespace: BrendaTissueOBO
def: "A key artery located in the front of the neck that carries blood from the heart to the brain. Cholesterol plaques on the inner wall of the carotid artery can lead to stroke." [Online Medical Dictionary:http\://cancerweb.ncl.ac.uk/]
is_a: BTO:0000573 ! artery
relationship: part_of BTO:0000420 ! neck

[Term]
id: BTO:0000169
name: calyx
namespace: BrendaTissueOBO
def: "The usually green outer whorl of a flower consisting of sepals." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=calyx]
synonym: "GRO:0005653" RELATED []
relationship: part_of BTO:0001727 ! perianth

[Term]
id: BTO:0000170
name: cambium
namespace: BrendaTissueOBO
def: "A thin formative layer between the xylem and phloem of most vascular plants that gives rise to new cells and is responsible for secondary growth;\nA lateral meristem in vascular plants, including the vascular cambium and cork cambium, that forms parallel rows of cells resulting in secondary tissues." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cambium, The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
synonym: "GRO:0005597" RELATED []
relationship: DRV BTO:0001119 ! procambium
relationship: part_of BTO:0001188 ! root
relationship: part_of BTO:0001299 ! stele

[Term]
id: BTO:0000171
name: L-cell
namespace: BrendaTissueOBO
def: "A cultured line of C3H mouse FIBROBLASTS that do not adhere to one another and do not express CADHERINS." [Medical Dictionary Online:http\://www.online-medical-dictionary.org/]
is_a: BTO:0000453 ! fibroblast cell line

[Term]
id: BTO:0000172
name: pileus
namespace: BrendaTissueOBO
def: "The convex, concave, or flattened spore-bearing structure of some basidiomycetes that is attached superiorly to the stem and typically is expanded with gills or pores on the underside." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=pileus]
synonym: "cap" RELATED []
relationship: part_of BTO:0000487 ! fruitbody

[Term]
id: BTO:0000173
name: fruit capsule
namespace: BrendaTissueOBO
def: "A simple fruit that develops from a compound ovary with two or more carpels; capsules dehisce in many ways, example: cotton." [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
synonym: "plant capsule" RELATED []
is_a: BTO:0000486 ! fruit
is_a: BTO:0001287 ! sporangium

[Term]
id: BTO:0000174
name: embryonic structure
namespace: BrendaTissueOBO
def: "An anatomical structure that exists only before the organism is fully formed. In mammals, for example, a structure that exists only prior to the birth of the organism. This structure may be normal or abnormal." [Harvard Medical School:http\://dsg.harvard.edu/courses/hst952/UMLSSemanticTypes.doc]
is_a: BTO:0000284 ! organism form
is_a: BTO:0001489 ! whole body

[Term]
id: BTO:0000175
name: epithalamus
namespace: BrendaTissueOBO
def: "The caudal part of the roof and the adjoining lateral walls of the third ventricle of the diencephalon, comprising the habenular nuclei and their commissure, pineal body, and commissure of the epithalamus." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=epithalamus]
relationship: part_of BTO:0000342 ! diencephalon

[Term]
id: BTO:0000176
name: carcinoma cell
namespace: BrendaTissueOBO
def: "A cell of malignant new growth made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases." [Dorlands Medical Dictionary:MerckSource]
synonym: "basal cell epithelioma cell" RELATED []
synonym: "epithelial cancer cell" RELATED []
synonym: "epithelial carcinoma cell" RELATED []
synonym: "malignant epithelioma cell" RELATED []
is_a: BTO:0000415 ! epithelioma cell

[Term]
id: BTO:0000177
name: BG-1 cell
namespace: BrendaTissueOBO
def: "Ovarian adenocarcinoma cell line." [PMID:11578462]
synonym: "BG1 cell" RELATED []
is_a: BTO:0001882 ! ovary adenocarcinoma cell line

[Term]
id: BTO:0000178
name: adenoma cell
namespace: BrendaTissueOBO
def: "A benign epithelial tumor cell in which the cells form recognizable glandular structures or in which the cells are clearly derived from glandular epithelium." [Dorlands Medical Dictionary:MerckSource]
is_a: BTO:0000415 ! epithelioma cell

[Term]
id: BTO:0000179
name: Colo-205 cell
namespace: BrendaTissueOBO
def: "Human Caucasian colon adenocarcinoma cell line. Isolated from ascitic fluid of a 70-year-old Caucasian male with carcinoma of the colon." [HyperCLDB:http\://www.biotech.ist.unige.it/]
synonym: "Colo205 cell" RELATED []
is_a: BTO:0001913 ! colonic adenocarcinoma cell line

[Term]
id: BTO:0000180
name: cervical carcinoma cell
namespace: BrendaTissueOBO
def: "A cancer cell of the uterine cervix (the neck of the uterus)." [The Cancer Information Network \, Medical Terms Used In Oncology:http\://www.cancerlinksusa.com/tools/glossary.htm]
synonym: "carcinoma cell, cervical" RELATED []
synonym: "carcinoma cell. cervix" RELATED []
synonym: "cervical cancer cell" RELATED []
synonym: "cervix carcinoma cell" RELATED []
is_a: BTO:0001421 ! uterine cervix

[Term]
id: BTO:0000181
name: Lewis lung carcinoma cell line
namespace: BrendaTissueOBO
synonym: "LLC cell line" RELATED []
is_a: BTO:0000762 ! lung cancer cell line
relationship: DRV BTO:0000745 ! Lewis lung carcinoma cell

[Term]
id: BTO:0000182
name: HT-29 cell
namespace: BrendaTissueOBO
def: "Human colon adenocarcinoma, established from the primary tumor of a 44-year-old Caucasian woman with colon adenocarcinoma in 1964; described to be heterotransplantable forming well-differentiated grade I tumors." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
is_a: BTO:0001913 ! colonic adenocarcinoma cell line

[Term]
id: BTO:0000183
name: pancreatic cell line
namespace: BrendaTissueOBO
relationship: DRV BTO:0000988 ! pancreas

[Term]
id: BTO:0000184
name: medullary thyroid carcinoma cell
namespace: BrendaTissueOBO
def: "A cell ot a type of thyroid gland carcinoma that contains amyloid deposits and parafollicular cells and secretes calcitonin. It occurs in both an autosomal dominant form as a component of multiple endocrine neoplasia, types II and III, and in a nonfamilial form." [Dorlands Medical Dictionary:MerckSource]
synonym: "medullary carcinoma cell of thyroid gland" RELATED []
synonym: "MTC cell" RELATED []
synonym: "thyroid carcinoma cell, medullary" RELATED []
is_a: BTO:0000191 ! medullary carcinoma cell
is_a: BTO:0000196 ! thyroid cancer cell

[Term]
id: BTO:0000185
name: medullary breast carcinoma cell
namespace: BrendaTissueOBO
def: "A cell of a rare type of breast cancer that often can be treated successfully. It is marked by lymphocytes (a type of white blood cell) in and around the tumor that can be seen when viewed under a microscope.  " [Glossary of Cancer terms:http\://www.webref.org/cancer/m/medullary_breast_carcinoma.htm]
is_a: BTO:0000150 ! breast cancer cell
is_a: BTO:0000191 ! medullary carcinoma cell

[Term]
id: BTO:0000186
name: lobular carcinoma cell
namespace: BrendaTissueOBO
def: "A cell of an infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumours in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. " [Online Medical Dictionary:http\://cancerweb.ncl.ac.uk/]
is_a: BTO:0000150 ! breast cancer cell

[Term]
id: BTO:0000187
name: myeloblast
namespace: BrendaTissueOBO
def: "A large mononuclear nongranular bone-marrow cell; especially: one that is a precursor of a myelocyte." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=myeloblast]
relationship: part_of BTO:0000141 ! bone marrow

[Term]
id: BTO:0000188
name: colonic cell line
namespace: BrendaTissueOBO
is_a: BTO:0000003 ! intestinal cell line
relationship: DRV BTO:0000269 ! colon

[Term]
id: BTO:0000189
name: small cell lung cancer cell
namespace: BrendaTissueOBO
def: "A cell of a common, highly malignant form of bronchogenic carcinoma in the wall of a major bronchus, occurring mainly in middle-aged individuals with a history of tobacco smoking; it is radiosensitive and has small oval undifferentiated cells that are intensely hematoxyphilic. Metastasis to the hilum and to mediastinal lymph nodes is common. " [Dorlands Medical Dictionary:MerckSource]
synonym: "SCLC cell" RELATED []
synonym: "small cell carcinoma cell" RELATED []
synonym: "small cell lung carcinoma cell" RELATED []
is_a: BTO:0002061 ! bronchogenic carcinoma cell

[Term]
id: BTO:0000190
name: Ehrlich tumor carcinoma cell
namespace: BrendaTissueOBO
def: "A Ehrlich tumor carcinoma is a transplantable, poorly differentiated malignant tumour  which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms. " [Online Medical Dictionary:http\://cancerweb.ncl.ac.uk/]
is_a: BTO:0000150 ! breast cancer cell

[Term]
id: BTO:0000191
name: medullary carcinoma cell
namespace: BrendaTissueOBO
def: "A cell of a carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. " [Online Medical Dictionary:http\://cancerweb.ncl.ac.uk/]
synonym: "carcinoma molle cell" RELATED []
synonym: "carcinoma spongiosum cell" RELATED []
synonym: "cerebriform cancer cell" RELATED []
synonym: "cerebriform carcinoma cell" RELATED []
synonym: "encephaloid cancer cell" RELATED []
synonym: "soft cancer cell" RELATED []
is_a: BTO:0000176 ! carcinoma cell

[Term]
id: BTO:0000192
name: nasopharyngeal carcinoma cell
namespace: BrendaTissueOBO
def: "A cell of a disease in which cancer (malignant) cells are found in the tissues of the nasopharynx." [The Cancer Center at Saint Mary's Mercy Medical Center \, Glossary of Terms:http\://www.smcancercenter.com/resource/n.shtml]
synonym: "carcinoma cell, nasopharynx" RELATED []
synonym: "nasopharyngeal cancer cell" RELATED []
synonym: "nasopharynx cancer cell" RELATED []
synonym: "nasopharynx carcinoma cell" RELATED []
is_a: BTO:0000176 ! carcinoma cell
relationship: DRV BTO:0000662 ! nasopharynx

[Term]
id: BTO:0000193
name: rectal cancer cell
namespace: BrendaTissueOBO
def: "Cancer cell of the rectum." [Atlas of Gastroenterological Endoscopy:http\://www.endoskopischer-atlas.de/lexe.htm]
synonym: "carcinoma cell, rectal" RELATED []
synonym: "rectal carcinoma cell" RELATED []
relationship: DRV BTO:0001158 ! rectum

[Term]
id: BTO:0000194
name: endometrioid carcinoma cell
namespace: BrendaTissueOBO
def: "Ovarian carcinoma cell which resembles typical carcinoma of the endometrium and may be seen with a synchronous endometrial carcinoma. When they appear together, both tend to be of low stage. " [Online Medical Dictionary:http\://cancerweb.ncl.ac.uk/]
is_a: BTO:0001023 ! ovary cancer cell
relationship: DRV BTO:0001422 ! uterine endometrium

[Term]
id: BTO:0000195
name: CACO-2 cell
namespace: BrendaTissueOBO
def: "Human colon adenocarcinoma cell line, established from the primary colon tumor (adenocarcinoma) of a 72-year-old Caucasian man in 1974." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
synonym: "Caco-2 cell" RELATED []
is_a: BTO:0001913 ! colonic adenocarcinoma cell line

[Term]
id: BTO:0000196
name: thyroid cancer cell
namespace: BrendaTissueOBO
def: "Cancer cell of the thyroid gland." [Aristoteles University of Thessaloniki \, Dictionary of Medical Terms:http\://www.med.auth.gr/db/dictionary1/gr/]
synonym: "carcinoma cell, thyroid" RELATED []
synonym: "thyroid carcinoma cell" RELATED []
relationship: DRV BTO:0001379 ! thyroid gland

[Term]
id: BTO:0000197
name: carcinosarcoma cell
namespace: BrendaTissueOBO
def: "A cell of a malignant tumor that is a mixture of carcinoma (cancer of epithelial tissue, which is skin and tissue that lines or covers the internal organs) and sarcoma (cancer of connective tissue, such as bone, cartilage, and fat).  " [Medical Dictionary \, Hyperdictionary:http\://www.hyperdictionary.com/medical/carcinosarcoma]
is_a: BTO:0000176 ! carcinoma cell
is_a: BTO:0001207 ! sarcoma cell

[Term]
id: BTO:0000198
name: cardia
namespace: BrendaTissueOBO
def: "The opening of the esophagus into the stomach; also: the part of the stomach adjoining this opening." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cardia]
relationship: part_of BTO:0000959 ! esophagus

[Term]
id: BTO:0000199
name: cardiac muscle
namespace: BrendaTissueOBO
def: "The principal muscle tissue of the vertebrate heart made up of striated fibers that appear to be separated from each other under the electron microscope but that function in long-term rhythmic contraction as if in protoplasmic continuity." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cardiac+muscle]
synonym: "heart muscle" RELATED []
relationship: part_of BTO:0000562 ! heart
relationship: part_of BTO:0001369 ! vertebrate muscular system

[Term]
id: BTO:0000200
name: culture condition:2-chloropropionate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000201
name: pheochromocytoma cell line
namespace: BrendaTissueOBO
relationship: DRV BTO:0001054 ! pheochromocytoma cell

[Term]
id: BTO:0000202
name: sense organ
namespace: BrendaTissueOBO
def: "A bodily structure that receives a stimulus (as heat or sound waves) and is affected in such a manner as to initiate a wave of excitation in associated sensory nerve fibers which convey specific impulses to the central nervous system where they are interpreted as corresponding sensations: RECEPTOR." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=sense+organ]
relationship: part_of BTO:0001489 ! whole body

[Term]
id: BTO:0000203
name: respiratory system
namespace: BrendaTissueOBO
def: "A system of organs subserving the function of respiration and in air-breathing vertebrates consisting typically of the lungs and their nervous and circulatory supply and the channels by which these are continuous with the outer air." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=respiratory+system]
synonym: "respiratory tract" RELATED []
relationship: part_of BTO:0001489 ! whole body

[Term]
id: BTO:0000204
name: carotid body
namespace: BrendaTissueOBO
def: "A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control." [Online Medical Dictionary:http\://cancerweb.ncl.ac.uk/]
is_a: BTO:0000202 ! sense organ
relationship: part_of BTO:0000168 ! carotid artery

[Term]
id: BTO:0000205
name: nerve plexus
namespace: BrendaTissueOBO
def: "A plexus made up of intermingled nerve fibers." [Dorlands Medical Dictionary:MerckSource]
relationship: DRV BTO:0000925 ! nerve

[Term]
id: BTO:0000206
name: cartilage
namespace: BrendaTissueOBO
def: "A specialized, fibrous connective tissue, forming most of the temporary skeleton of the embryo, providing a model in which most of the bones develop, and constituting an important part of the growth mechanism of the organism. It exists in several types, the most important of which are hyaline cartilage, elastic cartilage, and fibrocartilage. Also used as a general term to designate a mass of such tissue in a particular site in the body. " [Dorlands Medical Dictionary:MerckSource]
is_a: BTO:0000421 ! connective tissue
relationship: part_of BTO:0001486 ! skeletal system

[Term]
id: BTO:0000207
name: tibial cartilage
namespace: BrendaTissueOBO
def: "Cartilage pertaining to the tibia." [Dorlands Medical Dictionary:MerckSource]
is_a: BTO:0000206 ! cartilage
is_a: BTO:0001252 ! tibia

[Term]
id: BTO:0000208
name: caryopsis
namespace: BrendaTissueOBO
def: "Simple, dry, indehiscent fruit with a single seed that is fused to the ovary wall, example: wheat." [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
synonym: "grain" RELATED []
is_a: BTO:0000486 ! fruit

[Term]
id: BTO:0000209
name: corpus epididymis
namespace: BrendaTissueOBO
def: "The body of the epididymis." [Dorlands Medical Dictionary:MerckSource]
relationship: part_of BTO:0000408 ! epididymis

[Term]
id: BTO:0000210
name: cauda epididymis
namespace: BrendaTissueOBO
def: "The tail of the epididymis." [Dorlands Medical Dictionary:MerckSource]
synonym: "epididymal cauda" RELATED []
relationship: part_of BTO:0000408 ! epididymis

[Term]
id: BTO:0000211
name: caudate nucleus
namespace: BrendaTissueOBO
def: "One of the centrally-located portions of the brain affected by Huntington's Disease. Speech and swallowing problems arise when this region and another region called the putamen are affected." [Dictionary of Huntington's Disease (HD) Terms:http\://www.hdsa-wi.org/dictionary.htm]
relationship: part_of BTO:0000418 ! neostriatum
relationship: part_of BTO:0001311 ! corpus striatum

[Term]
id: BTO:0000212
name: caudate putamen
namespace: BrendaTissueOBO
def: "A centrally-located portion of the brain affected by Huntington's Disease. The putamen is structurally similar to the caudate nucleus together with which it composes what is termed the striatum." [Dictionary of Huntington's Disease (HD) Terms:http\://www.hdsa-wi.org/dictionary.htm]
relationship: part_of BTO:0000418 ! neostriatum
relationship: part_of BTO:0002250 ! nucleus lentiformis

[Term]
id: BTO:0000213
name: cecum mucosa
namespace: BrendaTissueOBO
is_a: BTO:0000642 ! intestinal mucosa
relationship: part_of BTO:0000166 ! cecum

[Term]
id: BTO:0000214
name: cell culture
namespace: BrendaTissueOBO
def: "Cells taken from a living organism and grown under controlled conditions (in culture). Methods used to maintain cell lines or strains." [Glossary of Fermentation & Cell Culture Terms:http\://www.nbsc.com/files/papers/bp0600_gloss_36-44.pdf]
is_a: BTO:0001490 ! other source

[Term]
id: BTO:0000215
name: culture condition:galactonate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000216
name: culture condition
namespace: BrendaTissueOBO
relationship: part_of BTO:0000214 ! cell culture

[Term]
id: BTO:0000217
name: MH-7777A cell
namespace: BrendaTissueOBO
def: "Rat hepatoma, established from the liver tumor of a Buffalo rat; tumor cells were propagated in the hind leg." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
is_a: BTO:0000578 ! hepatoma cell line

[Term]
id: BTO:0000218
name: BALB/3T3 cell
namespace: BrendaTissueOBO
def: "The BALB/3T3 clone A31 is one of several cell lines (see BALB/3T12) developed in 1968 from disaggregated 14- to 17-day-old BALB/c mouse embryos." [ATCC American Cell Type Culture Collection:http\://www.lgcstandards-atcc.org/]
synonym: "BALB/3T3 clone A31" RELATED []
synonym: "BALBc/3T3 cell" RELATED []
is_a: BTO:0001958 ! embryonic fibroblast cell line

[Term]
id: BTO:0000219
name: MH-3924 cell
namespace: BrendaTissueOBO
def: "Rat Morris hepatoma cell line." [PMID:12798353, PMID:3716925]
synonym: "MH3924 cell" RELATED []
is_a: BTO:0000578 ! hepatoma cell line

[Term]
id: BTO:0000220
name: MH1C1 cell
namespace: BrendaTissueOBO
def: "Rat hepatoma, a clonal strain of epithelial cells was derived from a transplantable Morris hepatoma (#7795, Buffalo strain) in 1967; cells were described to synthesize and to secrete serum albumin and serum complement component C9." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
synonym: "MH 1 C 1 cell" RELATED []
is_a: BTO:0000578 ! hepatoma cell line

[Term]
id: BTO:0000221
name: cell suspension culture
namespace: BrendaTissueOBO
def: "Particles floating in (not necessarily on) a liquid medium, or the mix of particles and liquid itself." [Glossary of Fermentation & Cell Culture Terms:http\://www.nbsc.com/files/papers/bp0600_gloss_36-44.pdf]
is_a: BTO:0000214 ! cell culture

[Term]
id: BTO:0000222
name: myoblast
namespace: BrendaTissueOBO
def: "An embryonic cell that becomes a cell of muscle fiber." [Dorlands Medical Dictionary:MerckSource]
synonym: "sarcoblast" RELATED []
relationship: part_of BTO:0000379 ! embryo

[Term]
id: BTO:0000223
name: teratocarcinoma cell
namespace: BrendaTissueOBO
def: "A malignant tumor cell of the testis composed of teratoma and embryonal carcinoma." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
is_a: BTO:0000279 ! testicular cancer cell

[Term]
id: BTO:0000224
name: liver cell line
namespace: BrendaTissueOBO
relationship: DRV BTO:0000759 ! liver

[Term]
id: BTO:0000225
name: CEM cell
namespace: BrendaTissueOBO
def: "CEM is a camptothecin (CPT) resistant derivative of the human T cell leukemia cell line CCRF-CEM. The cell line was selected and subcloned in 1991 for resistance to CPT. Established from an 4-year-old caucasian female." [ATCC American Cell Type Culture Collection:http\://www.lgcstandards-atcc.org/]
relationship: DRV BTO:0000736 ! CCRF-CEM cell

[Term]
id: BTO:0000226
name: gitter cell
namespace: BrendaTissueOBO
def: "A microglial cell that is globular and swollen after having phagocytized debris from cells destroyed pathologically in the central nervous system." [Dorlands Medical Dictionary:MerckSource]
synonym: "compound granular corpuscle" RELATED []
synonym: "compound granule cell" RELATED []
is_a: BTO:0000078 ! microglia

[Term]
id: BTO:0000227
name: central nervous system
namespace: BrendaTissueOBO
def: "The central nervous system is that part of the nervous system that consists of the brain and spinal cord. The central nervous system (CNS) is one of the two major divisions of the nervous system. The other is the peripheral nervous system (PNS) which is outside the brain and spinal cord. " [Medical Dictionary:http\://www.medterms.com/]
synonym: "CNS" RELATED []
relationship: part_of BTO:0001484 ! nervous system

[Term]
id: BTO:0000228
name: C-1300 cell
namespace: BrendaTissueOBO
def: "Mouse neuroblastoma cell line." [PMID:11579158]
synonym: "C1300 cell" RELATED []
is_a: BTO:0000932 ! neuroblastoma cell line

[Term]
id: BTO:0000229
name: centrum semiovale
namespace: BrendaTissueOBO
def: "The white matter of the cerebral hemispheres which underlies the cerebral cortex and which, in horizontal sections superior to the corpus callosum, has a semioval shape; it contains projection, commissural, and association fibers." [Dorlands Medical Dictionary:MerckSource]
synonym: "semioval center" RELATED []
relationship: part_of BTO:0000236 ! cerebral white matter

[Term]
id: BTO:0000230
name: subarachnoid space
namespace: BrendaTissueOBO
def: "The space between the arachnoidea mater and the pia mater, containing cerebrospinal fluid and bridged by delicate trabeculae." [Dorlands Medical Dictionary:MerckSource]
synonym: "cavitas subarachnoidea" RELATED []
synonym: "spatium leptomeningeum" RELATED []
synonym: "spatium subarachnoideum" RELATED []
synonym: "subarachnoid cavity" RELATED []
relationship: part_of BTO:0000818 ! spinal column

[Term]
id: BTO:0000231
name: cerebral hemisphere
namespace: BrendaTissueOBO
def: "Either of the two hollow convoluted lateral halves of the cerebrum." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cerebral+hemisphere]
relationship: part_of BTO:0000239 ! telencephalon

[Term]
id: BTO:0000232
name: cerebellum
namespace: BrendaTissueOBO
def: "A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cerebellum]
relationship: part_of BTO:0000673 ! metencephalon

[Term]
id: BTO:0000233
name: cerebral cortex
namespace: BrendaTissueOBO
def: "The surface layer of gray matter of the cerebrum that functions chiefly in coordination of sensory and motor information." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cerebral+cortex]
synonym: "brain cortex" RELATED []
relationship: part_of BTO:0000231 ! cerebral hemisphere

[Term]
id: BTO:0000234
name: vein
namespace: BrendaTissueOBO
def: "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=vein]
is_a: BTO:0001102 ! blood vessel

[Term]
id: BTO:0000235
name: basal ganglion
namespace: BrendaTissueOBO
def: "Any of four deeply placed masses of gray matter (as the amygdala) in each cerebral hemisphere. Location: The basal ganglion is located deep within the cerebral hemispheres in the telencephalon region of the brain. It consists of the corpus stratium, subthalamic nucleus and the substantia nigra. " [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=basal+ganglion]
synonym: "basal nucleus" RELATED []
is_a: BTO:0000497 ! ganglion
relationship: part_of BTO:0000233 ! cerebral cortex

[Term]
id: BTO:0000236
name: cerebral white matter
namespace: BrendaTissueOBO
def: "Whitish nerve tissue, especially of the brain and spinal cord, consisting chiefly of myelinated nerve fibers." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
synonym: "white matter" RELATED []
relationship: part_of BTO:0000142 ! brain
relationship: part_of BTO:0001279 ! spinal cord

[Term]
id: BTO:0000237
name: cerebrospinal fluid
namespace: BrendaTissueOBO
def: "The serumlike fluid that circulates through the ventricles of the brain, the cavity of the spinal cord, and the subarachnoid space, functioning in shock absorption." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
synonym: "cerebral spinal fluid" RELATED []
synonym: "CSF" RELATED []
synonym: "spinal fluid" RELATED []
relationship: DRV BTO:0000258 ! choroid plexus
relationship: part_of BTO:0000230 ! subarachnoid space
relationship: part_of BTO:0001279 ! spinal cord

[Term]
id: BTO:0000238
name: cerebrovascular endothelial cell
namespace: BrendaTissueOBO
def: "Endothelial cell of or involving the cerebrum and the blood vessels supplying it." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cerebrovascular]
is_a: BTO:0001854 ! vascular endothelial cell
relationship: part_of BTO:0000239 ! telencephalon
relationship: part_of BTO:0001852 ! cerebrovascular endothelium

[Term]
id: BTO:0000239
name: telencephalon
namespace: BrendaTissueOBO
def: "An enlarged anterior or upper part of the brain; especially: the expanded anterior portion of the brain that in higher mammals overlies the rest of the brain, consists of cerebral hemispheres and connecting structures, and is considered to be the seat of conscious mental processes." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=telencephalon]
synonym: "cerebrum" RELATED []
relationship: part_of BTO:0000478 ! forebrain

[Term]
id: BTO:0000240
name: inferior cervical ganglion
namespace: BrendaTissueOBO
def: "An inconstant ganglion formed in place of the usual cervicothoracic ganglion by fusion of the lower two cervical ganglia in instances where the first thoracic ganglion remains separate." [Dorlands Medical Dictionary:MerckSource]
synonym: "ganglion cervicale inferioris" RELATED []
is_a: BTO:0000113 ! cervical ganglion

[Term]
id: BTO:0000241
name: cervical epithelium
namespace: BrendaTissueOBO
is_a: BTO:0000416 ! epithelium
relationship: part_of BTO:0001421 ! uterine cervix

[Term]
id: BTO:0000242
name: cervical mucus
namespace: BrendaTissueOBO
def: "A substance produced by the cervix and endocervical glands." [Dictionary of Terms:http\://www.dreamababy.com/dictionary.htm]
relationship: REL BTO:0001421 ! uterine cervix

[Term]
id: BTO:0000243
name: vagina
namespace: BrendaTissueOBO
def: "A canal in a female mammal that leads from the uterus to the external orifice of the genital canal." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=vagina]
is_a: BTO:0003099 ! internal female genital organ
relationship: part_of BTO:0000083 ! female reproductive system

[Term]
id: BTO:0000244
name: culture condition:chlorobenzene-induced cell
namespace: BrendaTissueOBO
is_a: BTO:0000001 ! culture condition:-induced cell

[Term]
id: BTO:0000245
name: culture condition:chlorobenzoate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000246
name: CHO cell
namespace: BrendaTissueOBO
def: "Chinese hamster ovary cell line, that was initiated from an ovary biopsy of an adult Chinese hamster in 1957." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
is_a: BTO:0000977 ! ovary cell line

[Term]
id: BTO:0000247
name: shoot tip
namespace: BrendaTissueOBO
def: "The terminal bud (0.1 - 1.0 mm) of a plant, which consists of the apical meristem (0.05 - 0.1 mm) and the immediate surrounding leaf primordia and developing leaves and adjacent stem tissue." [Dictionary of Genomics (Japan):http\://cny.new21.net/dictionary/s-e.html]
synonym: "GRO:0000370" RELATED []
synonym: "shoot apex" RELATED []
relationship: part_of BTO:0001243 ! shoot

[Term]
id: BTO:0000248
name: chondroclast
namespace: BrendaTissueOBO
def: "A giant cell of the class that is believed associated with the absorption of cartilage." [Dorlands Medical Dictionary:MerckSource]
is_a: BTO:0000801 ! macrophage
relationship: part_of BTO:0000206 ! cartilage

[Term]
id: BTO:0000249
name: chondrocyte
namespace: BrendaTissueOBO
def: "Cartilage cells. They make the structural components of cartilage." [Cancer.gov Dictionary:http\://www.nci.nih.gov/dictionary]
synonym: "cartilage cell" RELATED []
is_a: BTO:0000206 ! cartilage

[Term]
id: BTO:0000250
name: chondrosarcoma cell
namespace: BrendaTissueOBO
def: "Chondrosarcoma is a malignant tumor derived from cartilage cells or their precursors, but lacking direct osteoid formation; it occurs predominantly in the pelvis, femur, and shoulder girdle in middle-aged to older adults. It may be primary, arising from cartilage cells, or secondary to a pre-existing benign lesion." [Dorlands Medical Dictionary:MerckSource]
is_a: BTO:0000372 ! bone cancer cell
is_a: BTO:0001207 ! sarcoma cell

[Term]
id: BTO:0000251
name: chorioallantois
namespace: BrendaTissueOBO
def: "A vascular fetal membrane composed of the fused chorion and adjacent wall of the allantois that in the hen's egg is used as a living culture medium for viruses and for tissues." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=chorioallantois]
synonym: "chorioallantoic membrane" RELATED []
is_a: BTO:0000473 ! fetal membrane

[Term]
id: BTO:0000252
name: chorion
namespace: BrendaTissueOBO
def: "The outer membrane of the two membranes enclosing the embryo in reptiles, birds, and mammals. In placental mammals it contributes to the development of the placenta." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
is_a: BTO:0000473 ! fetal membrane

[Term]
id: BTO:0000253
name: BEN cell
namespace: BrendaTissueOBO
def: "Human lung carcinoma; established from the supraclavicular tumor cells-containing lymph node of a 71-year-old man with poorly differentiated carcinoma of the lung." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
is_a: BTO:0000762 ! lung cancer cell line

[Term]
id: BTO:0000254
name: female reproductive gland
namespace: BrendaTissueOBO
is_a: BTO:0001488 ! endocrine gland
relationship: part_of BTO:0000083 ! female reproductive system

[Term]
id: BTO:0000255
name: brain cell line
namespace: BrendaTissueOBO
relationship: DRV BTO:0000142 ! brain

[Term]
id: BTO:0000256
name: myoblast cell line
namespace: BrendaTissueOBO
relationship: DRV BTO:0000222 ! myoblast

[Term]
id: BTO:0000257
name: uterine cancer cell
namespace: BrendaTissueOBO
relationship: DRV BTO:0001424 ! uterus

[Term]
id: BTO:0000258
name: choroid plexus
namespace: BrendaTissueOBO
def: "The choroid plexus is tissue located in the spaces inside the brain called ventricles. The choroid plexus makes the fluid that fills the ventricles and surrounds the brain and spinal cord." [Cancer.gov Dictionary:http\://www.nci.nih.gov/dictionary]
relationship: part_of BTO:0001442 ! brain ventricle

[Term]
id: BTO:0000259
name: chromaffin cell
namespace: BrendaTissueOBO
def: "A type of amine precursor uptake and decarboxylation cells that stain readily with chromium salts, their cytoplasmic granules taking on a characteristic brown color; they are found especially in cells of the adrenal medulla and in paraganglia of the coccygeal gland and carotid gland, along the sympathetic nerves, and in various organs. They contain chromaffin granules. " [Dorlands Medical Dictionary:MerckSource]
synonym: "pheochrome cell" RELATED []
synonym: "pheochromocytes" RELATED []
relationship: part_of BTO:0000049 ! adrenal medulla

[Term]
id: BTO:0000260
name: ciliary body
namespace: BrendaTissueOBO
def: "Tissue that includes the group of muscles that act on the eye lens to produce accommodation and the arterial circle of the iris. The inner ciliary epithelium is continuous with the pigmented retinal epithelium, the outer ciliary epithelium secretes the aqueous humour." [The Dictionary of Cell and Molecular Biology:Third Edition]
relationship: part_of BTO:0000439 ! eye

[Term]
id: BTO:0000261
name: culture condition:mannitol-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000262
name: clove
namespace: BrendaTissueOBO
def: "One of the small bulbs (as in garlic) developed in the axils of the scales of a large bulb." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=clove]
is_a: BTO:0000159 ! bulb

[Term]
id: BTO:0000263
name: P-388D1(IL-1) cell
namespace: BrendaTissueOBO
def: "Mouse monocytes-macrophages, established from the ascites of a DBA/2 mouse with a lymphoid neoplasm induced by methylcholanthrene and subsequently enriched for adherent (monocyte-macrophage) cells by selection (yielding this IL1-producing subclone); reported to produce IL-1 after stimulation with LPS or PMA, to phagocytize latex articles and to synthesize lysozyme." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
is_a: BTO:0000984 ! P-388D1 cell

[Term]
id: BTO:0000264
name: bone marrow cell line
namespace: BrendaTissueOBO
relationship: DRV BTO:0000141 ! bone marrow

[Term]
id: BTO:0000265
name: coagulating gland
namespace: BrendaTissueOBO
is_a: BTO:0000080 ! male reproductive gland

[Term]
id: BTO:0000266
name: cob
namespace: BrendaTissueOBO
def: "The central axis/core of the ear (distal end of the lateral branch/ear shoot) upon which the kernels (caryopses) are borne. The cob is similar to the central spike of the tassel (male inflorescence) in that it produces multiple rows of paired spikelets (polystichous phyllotaxy)." [Maize DB:http\://www.maizemap.org/MMP_Downloads/POC/Zea_mays_anatomy_ontology_definitions.txt]
comment: Zea mays.
synonym: "GRO:0005440" RELATED []
is_a: BTO:0001278 ! spike

[Term]
id: BTO:0000267
name: cochlea
namespace: BrendaTissueOBO
def: "A division of the bony labyrinth of the inner ear of higher vertebrates that is usually coiled like a snail shell and is the seat of the hearing organ." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cochlea]
relationship: part_of BTO:0003381 ! vestibular system

[Term]
id: BTO:0000268
name: coleoptile
namespace: BrendaTissueOBO
def: "The first leaf of a monocotyledon forming a protective sheath about the plumule." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=coleoptile]
synonym: "GRO:0005373" RELATED []
relationship: part_of BTO:0001495 ! plumule

[Term]
id: BTO:0000269
name: colon
namespace: BrendaTissueOBO
def: "The part of the large intestine that extends from the cecum to the rectum." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=colon]
relationship: part_of BTO:0000706 ! large intestine
relationship: part_of BTO:0001613 ! colorectum

[Term]
id: BTO:0000270
name: colon ascendens
namespace: BrendaTissueOBO
def: "The portion of the colon between the cecum and the right colic flexure." [Dorlands Medical Dictionary:MerckSource]
synonym: "ascending colon" RELATED []
relationship: part_of BTO:0000269 ! colon

[Term]
id: BTO:0000271
name: colonic mucosa
namespace: BrendaTissueOBO
synonym: "colon mucosa" RELATED []
is_a: BTO:0000642 ! intestinal mucosa
relationship: part_of BTO:0000269 ! colon

[Term]
id: BTO:0000272
name: colon transversum
namespace: BrendaTissueOBO
def: "The portion of the colon that runs transversely across the upper part of the abdomen, from the right to the left colic flexure." [Dorlands Medical Dictionary:MerckSource]
relationship: part_of BTO:0000269 ! colon

[Term]
id: BTO:0000273
name: ink gland
namespace: BrendaTissueOBO
def: "The ink gland and ink sac are specializations of the rectal gland. " [The Columbia Encyclopedia:Sixth Edition. 2001]
is_a: BTO:0001157 ! rectal gland

[Term]
id: BTO:0000274
name: apical bud
namespace: BrendaTissueOBO
def: "The uppermost bud on a stem." [Glossary of Gardening Terms:http\://www.geocities.com/impatients63/DictB.htm]
synonym: "terminal bud" RELATED []
is_a: BTO:0000158 ! plant bud

[Term]
id: BTO:0000275
name: colonocyte
namespace: BrendaTissueOBO
relationship: REL BTO:0000305 ! crypt

[Term]
id: BTO:0000276
name: colostrum
namespace: BrendaTissueOBO
def: "Milk secreted for a few days after parturition and characterized by high protein and antibody content." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=colostrum]
is_a: BTO:0000868 ! milk

[Term]
id: BTO:0000277
name: columnella muscle
namespace: BrendaTissueOBO
def: "The muscle of the central column or axis of a spiral univalve shell." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=columella]
synonym: "columella muscle" RELATED []
is_a: BTO:0001262 ! soft body part
relationship: part_of BTO:0001266 ! invertebrate muscular system

[Term]
id: BTO:0000278
name: commercial preparation
namespace: BrendaTissueOBO
synonym: "commercial product" RELATED []
is_a: BTO:0001490 ! other source

[Term]
id: BTO:0000279
name: testicular cancer cell
namespace: BrendaTissueOBO
def: "Cancer that forms in tissues of the testis. Testicular cancer usually occurs in young or middle-aged men. Two main types of testicular cancer are seminomas (cancers that grow slowly and are sensitive to radiation therapy) and nonseminomas (different cell types that grow more quickly than seminomas)." [Dictionary of Cancer Terms:http\://www.cancer.gov/]
synonym: "testicular carcinoma cell" RELATED []
relationship: DRV BTO:0001363 ! testis

[Term]
id: BTO:0000280
name: cone
namespace: BrendaTissueOBO
def: "A mass of ovule-bearing or pollen-bearing scales or bracts in trees of the pine family or in cycads that are arranged usually on a somewhat elongated axis." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cone]
is_a: BTO:0000469 ! flower

[Term]
id: BTO:0000281
name: conidiophore
namespace: BrendaTissueOBO
def: "A specialized fungal hypha that produces conidia." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
is_a: BTO:0000612 ! hypha

[Term]
id: BTO:0000282
name: head
namespace: BrendaTissueOBO
def: "The upper or anterior division of the animal body that contains the brain, the chief sense organs, and the mouth." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=head]
relationship: part_of BTO:0001493 ! trunk

[Term]
id: BTO:0000283
name: conidium
namespace: BrendaTissueOBO
def: "An asexual spore produced on a conidiophore." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=conidium]
synonym: "conidiospore" RELATED []
is_a: BTO:0001171 ! spore
relationship: part_of BTO:0000281 ! conidiophore

[Term]
id: BTO:0000284
name: organism form
namespace: BrendaTissueOBO
is_a: BTO:0001489 ! whole body

[Term]
id: BTO:0000285
name: corm
namespace: BrendaTissueOBO
def: "A rounded thick modified underground stem base bearing membranous or scaly leaves and buds and acting as a vegetative reproductive structure." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=corm]
synonym: "GRO:0005787" RELATED []
is_a: BTO:0000720 ! plant form
is_a: BTO:0001300 ! stem

[Term]
id: BTO:0000286
name: cornea
namespace: BrendaTissueOBO
def: "The transparent part of the coat of the eyeball that covers the iris and pupil and admits light to the interior." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cornea]
relationship: part_of BTO:0000439 ! eye

[Term]
id: BTO:0000287
name: corneal epithelium
namespace: BrendaTissueOBO
def: "Posterior epithelium of cornea: the mesothelial layer covering the posterior surface of the posterior limiting lamina of the cornea; it was once believed to extend to the anterior surface of the stroma of the iris." [Dorlands Medical Dictionary:MerckSource]
synonym: "anterior endothelium of cornea" RELATED []
synonym: "corneal endothelium" RELATED []
synonym: "endothelium anterius corneae" RELATED []
synonym: "endothelium camerae anterioris bulbi" RELATED []
synonym: "endothelium corneale" RELATED []
synonym: "epithelium posterius corneae" RELATED []
relationship: part_of BTO:0000286 ! cornea

[Term]
id: BTO:0000288
name: corona
namespace: BrendaTissueOBO
def: "An appendage or series of united appendages on the inner side of the corolla in some flowers (as the daffodil, jonquil, or milkweed)." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=corona]
synonym: "paracorolla" RELATED []
relationship: part_of BTO:0000163 ! corolla

[Term]
id: BTO:0000289
name: cytotoxic T-cell
namespace: BrendaTissueOBO
def: "Subset of T-lymphocytes (mostly CD8+) responsible for lysing target cells and for killing virus-infected cells." [The Dictionary of Cell and Molecular Biology:Third Edition]
synonym: "CTL" RELATED []
synonym: "cytolytic T-cell" RELATED []
synonym: "cytolytic T-lymphocyte" RELATED []
synonym: "cytotoxic T-lymphocyte" RELATED []
synonym: "killer T-cell" RELATED []
synonym: "killer T-lymphocyte" RELATED []
is_a: BTO:0000782 ! T-lymphocyte

[Term]
id: BTO:0000290
name: coronary artery
namespace: BrendaTissueOBO
def: "Either of two arteries that arise one from the left and one from the right side of the aorta immediately above the semilunar valves and supply the tissues of the heart itself." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=coronary+artery]
is_a: BTO:0000573 ! artery

[Term]
id: BTO:0000291
name: corpus allatum
namespace: BrendaTissueOBO
def: "One of a pair of separate or fused bodies in many insects that are sometimes closely associated with the corpora cardiaca and that secrete hormones (as juvenile hormone)." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=allatum]
synonym: "corpora allata" RELATED []
is_a: BTO:0001488 ! endocrine gland
is_a: BTO:0001803 ! retrocerebral complex

[Term]
id: BTO:0000292
name: corpus luteum
namespace: BrendaTissueOBO
def: "A yellowish mass of progesterone-secreting endocrine tissue that forms immediately after ovulation from the ruptured graafian follicle in the mammalian ovary." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=corpus+luteum]
synonym: "luteal gland" RELATED []
is_a: BTO:0000389 ! mature ovarian follicle

[Term]
id: BTO:0000293
name: occipital lobe
namespace: BrendaTissueOBO
def: "This lobe is located at the back of the head and is involved in vision and reading." [Princeton University \, Department of Molecular Biology:http\://www.molbio.princeton.edu/courses/mb427/2000/projects/0008/anatobrainmain.html]
synonym: "occipital cortex" RELATED []
relationship: part_of BTO:0000445 ! cerebral lobe

[Term]
id: BTO:0000294
name: dermis
namespace: BrendaTissueOBO
def: "The sensitive vascular inner mesodermic layer of the skin." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=dermis]
synonym: "corium" RELATED []
synonym: "cutis" RELATED []
relationship: part_of BTO:0001253 ! skin

[Term]
id: BTO:0000295
name: WEHI-3 cell
namespace: BrendaTissueOBO
def: "Mouse, BALB/c, monocyte, monocytic leukemia cell line." [HyperCLDB:http\://www.biotech.ist.unige.it/]
is_a: BTO:0002332 ! monocytic leukemia cell line

[Term]
id: BTO:0000296
name: SW-1088 cell
namespace: BrendaTissueOBO
def: "Brain astrocytoma cell line. The SW 1088 cell line was initiated by A. Leibovitz at the Scott and White Clinic, Temple, Texas in 1975 from an astrocytoma taken from a 72 year old male Caucasian." [ATCC American Cell Type Culture Collection:http\://www.lgcstandards-atcc.org/]
synonym: "SW1088 cell" RELATED []
is_a: BTO:0000101 ! astrocytoma cell line

[Term]
id: BTO:0000297
name: carcinoma cell line
namespace: BrendaTissueOBO
is_a: BTO:0001120 ! epithelial cell line
relationship: DRV BTO:0000176 ! carcinoma cell

[Term]
id: BTO:0000298
name: COS-7 cell
namespace: BrendaTissueOBO
def: "African green monkey kidney derived from CV-1, a simian cell line (cercopithecus aethiops), by transformation with an origin-defective mutant of SV-40; cells were described to support the growth of SV-40 viruses." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
synonym: "COS7 cell" RELATED []
is_a: BTO:0000067 ! kidney cell line

[Term]
id: BTO:0000299
name: cotton fiber
namespace: BrendaTissueOBO
def: "Each seed of a cotton plant is surrounded with downy fiber, white or creamy in color and easily spun. The fibers flatten and twist naturally as they dry." [The Columbia Encyclopedia:Sixth Edition. 2001]
synonym: "cotton fibre" RELATED []
is_a: BTO:0000450 ! fiber
relationship: REL BTO:0001226 ! seed

[Term]
id: BTO:0000300
name: cotyledon
namespace: BrendaTissueOBO
def: "A seed leaf; the first leaf formed in a seed." [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
synonym: "GRO:0005358" RELATED []
is_a: BTO:0000713 ! leaf
relationship: DRV BTO:0001226 ! seed
relationship: part_of BTO:0001233 ! plant embryo

[Term]
id: BTO:0000301
name: crop
namespace: BrendaTissueOBO
def: "A pouched enlargement of the gullet of many birds that serves as a receptacle for food and for its preliminary maceration; also: an enlargement of the gullet of another animal (as an insect)." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=crop]
relationship: part_of BTO:0001049 ! pharynx

[Term]
id: BTO:0000302
name: ring gland
namespace: BrendaTissueOBO
def: "Hormonal cells involved in the production and release of ecdysone and juvenile hormone." [East Tennessee State University \, Department of Biological Sciences \, Dr. Karl H. Joplin:http\://www.etsu.edu/biology/joplin.htm]
relationship: part_of BTO:0000291 ! corpus allatum
relationship: part_of BTO:0000432 ! corpus cardiacum
relationship: part_of BTO:0000707 ! larva
relationship: part_of BTO:0001143 ! pupa
relationship: part_of BTO:0001368 ! thorax

[Term]
id: BTO:0000303
name: crown gall
namespace: BrendaTissueOBO
def: "A disease that affects many species of plants and is caused by a bacterium (Agrobacterium tumefaciens) which forms tumorous enlargements just below the ground on the stem." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=crown+gall]
is_a: BTO:0000677 ! plant tumor tissue

[Term]
id: BTO:0000304
name: PANC-1 cell
namespace: BrendaTissueOBO
def: "Human, Caucasian, pancreas, carcinoma cell line. Established from a pancreatic carcinoma of ductal origin from a 56-year-old Caucasian male. Cells possess the type B phenotype for G6PD." [HyperCLDB:http\://www.biotech.ist.unige.it/]
is_a: BTO:0000794 ! pancreatic cancer cell line

[Term]
id: BTO:0000305
name: crypt
namespace: BrendaTissueOBO
def: "A crypt is a deep pit that protrudes down into the connective tissue surrounding the small intestine. The epithelium at the base of the crypt is the site of stem cell proliferation and the differentiated cells move upwards and are shed 3-5 days later at the tips of the villi." [The Dictionary of Cell and Molecular Biology:Third Edition]
relationship: part_of BTO:0000651 ! small intestine
relationship: REL BTO:0000421 ! connective tissue

[Term]
id: BTO:0000306
name: teratocarcinoma cell line
namespace: BrendaTissueOBO
is_a: BTO:0001560 ! testicular cancer cell line
relationship: DRV BTO:0000223 ! teratocarcinoma cell

[Term]
id: BTO:0000307
name: crystalline style
namespace: BrendaTissueOBO
def: "The crystalline style, a gelatinous rod, projects into the stomach and stirs the contents as well as produces digestive enzymes to aid digestion. " [Aquaculture Curriculum Guide:http\://aquanic.org/publicat/govagen/ncae/bcccult.pdf]
comment: In mollusks, valves.
relationship: part_of BTO:0000511 ! gastrointestinal tract

[Term]
id: BTO:0000308
name: cytotoxic T-lymphocyte cell line
namespace: BrendaTissueOBO
synonym: "CTL cell line" RELATED []
is_a: BTO:0001045 ! T-lymphocyte cell line

[Term]
id: BTO:0000309
name: bundle sheath cell
namespace: BrendaTissueOBO
def: "Cells surrounding the vascular bundle in C4 plants." [PAE Virtual Glossary \, \"Plants \, Animals \, and the Environment\" Glossary derived from leading WCB/McGraw-Hill textbooks:http\://www.mhhe.com/biosci/pae/glossary.html]
synonym: "GRO:0005728" RELATED []
relationship: part_of BTO:0000160 ! bundle sheath

[Term]
id: BTO:0000310
name: protophloem
namespace: BrendaTissueOBO
def: "The first-formed phloem that develops from procambium, consists of narrow thin-walled cells capable of a limited amount of stretching, and is usually associated with a region of rapid growth." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=protophloem]
synonym: "GRO:0000346" RELATED []
relationship: DRV BTO:0001119 ! procambium

[Term]
id: BTO:0000311
name: culture filtrate
namespace: BrendaTissueOBO
relationship: part_of BTO:0000214 ! cell culture

[Term]
id: BTO:0000312
name: motoneuron
namespace: BrendaTissueOBO
def: "A neuron with a motor function; an efferent neuron conveying motor impulses." [Dorlands Medical Dictionary:MerckSource]
synonym: "motor neuron" RELATED []
is_a: BTO:0000938 ! neuron

[Term]
id: BTO:0000313
name: hypodermis
namespace: BrendaTissueOBO
def: "1: Subcutaneous tissue.  \n2: The outer cellular layer of the body of invertebrates which secretes the cuticular exoskeleton." [Dorlands Medical Dictionary:MerckSource]
is_a: BTO:0000634 ! integument

[Term]
id: BTO:0000314
name: neuroepithelium
namespace: BrendaTissueOBO
def: "1: Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue. \n2: The epithelium of the ectoderm, from which the central nervous system is developed." [Dorlands Medical Dictionary:MerckSource]
synonym: "sensory epithelium" RELATED []
is_a: BTO:0000416 ! epithelium
relationship: part_of BTO:0000315 ! ectoderm

[Term]
id: BTO:0000315
name: ectoderm
namespace: BrendaTissueOBO
def: "The outer of the three germ layers of the embryo (the other two being mesoderm and endoderm). Ectoderm gives rise to epidermis and neural tissue." [The Dictionary of Cell and Molecular Biology:Third Edition]
is_a: BTO:0000556 ! germ layer

[Term]
id: BTO:0000316
name: culture medium
namespace: BrendaTissueOBO
def: "A substance, either solid or liquid, used for the cultivation, isolation, identification, or storage of microorganisms." [Biology-Online Dictionary:http\://www.biology-online.org/dictionary/]
synonym: "growth medium" RELATED []
synonym: "medium" RELATED []
synonym: "nutrient medium" RELATED []
relationship: part_of BTO:0000214 ! cell culture

[Term]
id: BTO:0000317
name: caulonema
namespace: BrendaTissueOBO
def: "The secondary, bud-generating part of the filamentous moss protonema, typically reddish-brown, having few chloroplasts and consisting of long cells with oblique end walls." [Glossarium Polyglottum Bryoloigiae:http\://mobot.mobot.org/cgi-bin/search_vast?GLOSE=208]
relationship: part_of BTO:0001134 ! protonema

[Term]
id: BTO:0000318
name: CV-1 cell
namespace: BrendaTissueOBO
alt_id: BTO:0002653
def: "Normal kidney cell line. The CV-1 cell line was derived from the kidney of a male adult African green monkey by F.C. Jensen, et al. in March, 1964 for use in Rous sarcoma virus transformation studies." [ATCC American Cell Type Culture Collection:http\://www.lgcstandards-atcc.org/]
synonym: "CV 1 cell" RELATED []
synonym: "CV1 cell" RELATED []
is_a: BTO:0000067 ! kidney cell line
is_a: BTO:0000453 ! fibroblast cell line

[Term]
id: BTO:0000319
name: culture condition:cyclohexanol-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000320
name: cyst
namespace: BrendaTissueOBO
def: "A body resembling a cyst: as a \n1. capsule formed about a minute organism going into a resting or spore stage; also: this capsule with its contents.\n2. a resistant cover about a parasite produced by the parasite or the host." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cyst]
is_a: BTO:0000139 ! body wall
is_a: BTO:0000284 ! organism form

[Term]
id: BTO:0000321
name: plant cuticle
namespace: BrendaTissueOBO
def: "A thin continuous fatty or waxy film on the external surface of many higher plants that consists chiefly of cutin." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=cuticle]
synonym: "GRO:0005686" RELATED []
relationship: part_of BTO:0000718 ! leaf epidermis

[Term]
id: BTO:0000322
name: cytotrophoblast
namespace: BrendaTissueOBO
def: "The cellular (inner) layer of the trophoblast. " [Dorlands Medical Dictionary:MerckSource]
synonym: "Langhans' layer" RELATED []
relationship: part_of BTO:0001079 ! trophoblast

[Term]
id: BTO:0000323
name: culture condition:D-mandelate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000324
name: culture condition:D-arabinose-induced cell
namespace: BrendaTissueOBO
is_a: BTO:0000001 ! culture condition:-induced cell

[Term]
id: BTO:0000325
name: culture condition:D-galactose-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000326
name: culture condition:D-lyxose-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000327
name: culture condition:D-mannose-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000328
name: culture condition:D-phenylglycine-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000329
name: culture condition:D-ribose-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000330
name: culture condition:D-ribose-induced cell
namespace: BrendaTissueOBO
is_a: BTO:0000001 ! culture condition:-induced cell

[Term]
id: BTO:0000331
name: L-929 cell
namespace: BrendaTissueOBO
def: "Mouse connective tissue fibroblast, established from the normal subcutaneous areolar and adipose tissue of a male C3H/An mouse; used as target in TNF detection assays." [Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH:DSMZ]
synonym: "L929 cell" RELATED []
synonym: "NCTC clone 929" RELATED []
is_a: BTO:0000453 ! fibroblast cell line

[Term]
id: BTO:0000332
name: culture condition:dark-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000333
name: renal corpuscle
namespace: BrendaTissueOBO
def: "A mass of arterial capillaries enveloped in a capsule and attached to a tubule in the kidney." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
synonym: "Malphigian corpuscle" RELATED []
relationship: part_of BTO:0000924 ! nephron

[Term]
id: BTO:0000334
name: decidua parietalis
namespace: BrendaTissueOBO
def: "The part of the decidua in the pregnant human female lining the uterus . " [Fast Health Medical Dictionary:http\://www.fasthealth.com/dictionary/]
synonym: "decidua vera" RELATED []
relationship: part_of BTO:0001360 ! decidua

[Term]
id: BTO:0000335
name: deciduoma cell
namespace: BrendaTissueOBO
def: "1: A cell of a mass of tissue formed in the uterus following pregnancy that contains remnants of chorionic or decidual tissue.\n2: A cell of decidual tissue induced in the uterus (as by trauma) in the absence of pregnancy." [Fast Health Medical Dictionary:http\://www.fasthealth.com/dictionary/]
relationship: DRV BTO:0001360 ! decidua

[Term]
id: BTO:0000336
name: caput epididymis
namespace: BrendaTissueOBO
def: "The head of the epididymis." [Dorlands Medical Dictionary:MerckSource]
relationship: part_of BTO:0000408 ! epididymis

[Term]
id: BTO:0000337
name: dental follicle
namespace: BrendaTissueOBO
def: "The structure within the developing alveolar bone of the jaws enclosing the tooth germ. " [Dorlands Medical Dictionary:MerckSource]
synonym: "tooth follicle" RELATED []
is_a: BTO:0001511 ! tooth germ
relationship: REL BTO:0001090 ! mouth

[Term]
id: BTO:0000338
name: dental plaque
namespace: BrendaTissueOBO
def: "A soft, thin film of food debris, mucin, and dead epithelial cells deposited on the teeth, providing the medium for the growth of various bacteria. The main inorganic components are calcium and phosphorus, with small amounts of magnesium, potassium, and sodium; the organic matrix consists of polysaccharides, proteins, carbohydrates, lipids, and other components. Plaque plays an important etiologic role in the development of dental caries and periodontal and gingival diseases and provides the base for the development of materia alba; calcified plaque forms dental calculus." [Dorlands Medical Dictionary:MerckSource]
synonym: "bacterial plaque" RELATED []
relationship: REL BTO:0000397 ! tooth

[Term]
id: BTO:0000339
name: dental pulp
namespace: BrendaTissueOBO
def: "The soft sensitive tissue that fills the central cavity of a tooth." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=dental+pulp]
synonym: "dental pulp cell" RELATED []
relationship: part_of BTO:0000397 ! tooth

[Term]
id: BTO:0000340
name: culture condition:deoxyribonucleoside-induced cell
namespace: BrendaTissueOBO
is_a: BTO:0000001 ! culture condition:-induced cell

[Term]
id: BTO:0000341
name: diaphragm
namespace: BrendaTissueOBO
def: "The thin muscle below the lungs and heart that separates the chest from the abdomen." [Cancer.gov Dictionary:http\://www.nci.nih.gov/dictionary]
synonym: "diaphragm muscle" RELATED []
is_a: BTO:0000508 ! thorax muscle
relationship: part_of BTO:0000088 ! cardiovascular system

[Term]
id: BTO:0000342
name: diencephalon
namespace: BrendaTissueOBO
def: "The posterior subdivision of the forebrain." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=diencephalon]
synonym: "betweenbrain" RELATED []
synonym: "interbrain" RELATED []
relationship: part_of BTO:0000478 ! forebrain

[Term]
id: BTO:0000343
name: renal tubule
namespace: BrendaTissueOBO
def: "One of the minute, reabsorptive, secretory, and collecting canals, made up of basement membrane lined with epithelium, that form the substance of the kidneys." [Dorlands Medical Dictionary:MerckSource]
relationship: part_of BTO:0000924 ! nephron

[Term]
id: BTO:0000344
name: stratum corneum
namespace: BrendaTissueOBO
def: "The horny outer layer of the epidermis, consisting mainly of dead or peeling cells." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
synonym: "horny layer" RELATED []
relationship: part_of BTO:0000404 ! epidermis

[Term]
id: BTO:0000345
name: digestive gland
namespace: BrendaTissueOBO
def: "A gland, such as the liver or pancreas, that secretes into the alimentary canal substances necessary for digestion." [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
is_a: BTO:0001488 ! endocrine gland

[Term]
id: BTO:0000346
name: digestive juice
namespace: BrendaTissueOBO
synonym: "digestive fluid" RELATED []
relationship: DRV BTO:0000345 ! digestive gland

[Term]
id: BTO:0000347
name: reticulum
namespace: BrendaTissueOBO
def: "The second compartment of the stomach of a ruminant in which folds of the mucous membrane form hexagonal cells." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=reticulum]
is_a: BTO:0000480 ! forestomach

[Term]
id: BTO:0000348
name: omasum
namespace: BrendaTissueOBO
def: "The third division of the stomach of a ruminant animal, located between the abomasum and the reticulum" [The American HeritageŽ Dictionary of the English Language:Fourth Edition. 2000.]
is_a: BTO:0000480 ! forestomach

[Term]
id: BTO:0000349
name: gut cavity
namespace: BrendaTissueOBO
relationship: part_of BTO:0000545 ! gut

[Term]
id: BTO:0000350
name: culture condition:dimethylamine-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000351
name: disc
namespace: BrendaTissueOBO
def: "The central part of the flower head of a typical composite made up of closely packed tubular flowers." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=disc]
synonym: "discus" RELATED []
synonym: "disk" RELATED []
relationship: part_of BTO:0000469 ! flower

[Term]
id: BTO:0000352
name: culture condition:DL-mandelate-grown cell
namespace: BrendaTissueOBO
is_a: BTO:0001479 ! culture condition:-grown cell

[Term]
id: BTO:0000353
name: lung cell line
namespace: BrendaTissueOBO
relationship: DRV BTO:0000763 ! lung

[Term]
id: BTO:0000354
name: DON cell
namespace: BrendaTissueOBO
def: "Lung cell line, established from a 8-months-old male of Cricetulus griseus (hamster, Chinese)." [ATCC American Cell Type Culture Collection:http\://www.lgcstandards-atcc.org/]
is_a: BTO:0000353 ! lung cell line

[Term]
id: BTO:0000355
name: dormant eye
namespace: BrendaTissueOBO
def: "An undeveloped growth bud." [Gardening Glossary:http\://www.boldweb.com/greenweb/glossary.htm]
is_a: BTO:0000158 ! plant bud
relationship: part_of BTO:0000285 ! corm

[Term]
id: BTO:0000356
name: breast cancer cell line
namespace: BrendaTissueOBO
is_a: BTO:0000816 ! breast cell line
relationship: DRV BTO:0000150 ! breast cancer cell

[Term]
id: BTO:0000357
name: nectary
namespace: BrendaTissueOBO
def: "A plant gland that secretes nectar." [From Merriam-Webster's Online Dictionary at www.Merriam-Webster.com:http\://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=nectary]
relationship: part_of BTO:0000469 ! flower

[Term]
id: BTO:0000358
name: McA-RH7777 cell
namespace: BrendaTissueOBO
alt_id: BTO:0003305
def: "Liver, hepatoma; Morris hepatoma 7777 cell line, established from a rattus norvegicus female." [ATCC American Cell Type Culture Collection:http\://www.lgcstandards-atcc.org/]
synonym: "McArdle-RH7777 cell" RELATED []
synonym: "McArdleRH7777 cell" RELATED []
synonym: "McARH7777 hepatoma cell" RELATED []
is_a: BTO:0000578 ! hepatoma cell line

[Term]
id: BTO:0000359
name: middle cervical ganglion
namespace: BrendaTissueOBO
def: "A variable ganglion, often fused with the vertebral ganglion, on the sympathetic trunk at about the level of the cricoid cartilage; its postganglionic fibers are distributed mainly to the heart, cervical region, and upper limb." [Dorlands Medical Dictionary:MerckSource]
synonym: "ganglion cervicale medium" RELATED []
is_a: BTO:0000113 ! cervical ganglion

[Term]
id: BTO:0000360
name: posterior spinal root
namespace: BrendaTissueOBO
def: "The sensory division of each spinal nerve, attached centrally to the spinal cord and joining peripherally with the anterior (motor) root to form the nerve before it emerges through the intervertebral forame