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Gene ontology
Version 2014-12-22
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Details for peptide-methionine (S)-S-oxide reductase activity
1.8.4.11
Gene ontology ID
GO:0008113
Definition
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin
Synonyms
1. methionine S-oxide reductase (S-form oxidizing) activity
2. methionine S-oxide reductase activity
3. methionine sulfoxide (protein) reductase activity
4. methionine sulfoxide reductase A activity
5. methionine sulfoxide reductase activity
6. methionine sulphoxide reductase A activity
7. MsrA
8. peptide Met(O) reductase activity
9. peptide methionine sulfoxide reductase activity
10. peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity
11. peptide-methionine-(S)-S-oxide reductase activity
12. protein-methionine-S-oxide reductase activity
References
1. EC 1.8.4.11
2. GOC: mah
3. GOC: vw
4. PMID 11169920
5. MetaCyc RXN-8668
6. MetaCyc RXN-8669
7. Reactome: R-HSA-1222363 "MsrA/B reduces peptide-methionine S/R-sulfoxides"
8. Reactome: R-HSA-5676940 "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine"
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derives from the parent element
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