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Gene ontology
Version 2014-12-22
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Details for alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
2.4.99.8
Gene ontology ID
GO:0003828
Definition
Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Synonyms
1. alpha-2,8-sialyltransferase activity
2. alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity
3. CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity
4. CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity
5. CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity
6. cytidine monophosphoacetylneuraminate-ganglioside GM3
7. ganglioside GD3 synthase activity
8. ganglioside GD3 synthetase sialyltransferase activity
9. GD3 synthase activity
10. SAT-2
References
1. EC 2.4.99.8
2. MetaCyc 2.4.99.8-RXN
3. Reactome: R-HSA-1022133 "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans"
4. Reactome: R-HSA-4084978 "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues"
5. Reactome: R-HSA-422454 "Polysialylation of NCAM1"
6. RHEA: 19313
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