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Gene ontology
Version 2014-12-22
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Details for protein-glutamine gamma-glutamyltransferase activity
2.3.2.13
Gene ontology ID
GO:0003810
Definition
Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links
Synonyms
1. factor XIIIa
2. fibrin stabilizing factor
3. fibrinoligase activity
4. glutaminylpeptide gamma-glutamyltransferase activity
5. polyamine transglutaminase activity
6. protein-glutamine:amine gamma-glutamyltransferase
7. R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
8. TGase activity
9. tissue transglutaminase
10. transglutaminase activity
References
1. EC 2.3.2.13
2. RESID AA0124
3. MetaCyc 2.3.2.13-RXN
4. Reactome: R-HSA-140851 "fibrin multimer -> fibrin multimer, crosslinked + NH4+"
5. Reactome: R-HSA-6810894 "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
catalytic activity, acting on a protein is a
transferase activity, transferring amino-acyl groups is a
protein-glutamine gamma-glutamyltransferase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
alpha-1,4-glucan-protein synthase (ADP-forming) activity is a
biotin-protein ligase activity is a
catalytic activity, acting on a glycoprotein is a
deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity is a
dihydrolipoyllysine-residue acetyltransferase activity is a
dihydrolipoyllysine-residue succinyltransferase activity is a
GPI-anchor transamidase activity is a
lipoate-protein ligase activity is a
peptidyl-aspartic acid 3-dioxygenase activity is a
peptidyl-lysine N6-palmitoyltransferase activity is a
peptidylamidoglycolate lyase activity is a
phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity is a
polypeptide N-acetylgalactosaminyltransferase activity is a
procollagen galactosyltransferase activity is a
procollagen glucosyltransferase activity is a
protein disulfide isomerase activity is a
protein methylesterase activity is a
protein methylthiotransferase activity is a
protein N-acetylglucosaminyltransferase activity is a
protein O-GlcNAc transferase activity is a
protein prenyltransferase activity is a
protein xylosyltransferase activity is a
protein-cysteine S-acyltransferase activity is a
protein-fructosamine 3-kinase activity is a
protein-glucosylgalactosylhydroxylysine glucosidase activity is a
protein-glutamic acid ligase activity is a
protein-glycine ligase activity is a
protein-ribulosamine 3-kinase activity is a
protein-tyrosine sulfotransferase activity is a
Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity is a
transferase activity, transferring amino-acyl groups is a
3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine gamma-glutamylcyclotransferase activity is a
agaritine gamma-glutamyltransferase activity is a
alanylphosphatidylglycerol synthase activity is a
aspartyltransferase activity is a
D-alanine gamma-glutamyltransferase activity is a
D-glutamyltransferase activity is a
eoxin D4 synthase activity is a
glutaminyl-peptide cyclotransferase activity is a
glutathione gamma-glutamylcysteinyltransferase activity is a
homophytochelatin synthase (dimmer forming) activity is a
homophytochelatin synthase activity (polymer-forming) is a
hypoglycin A gamma-glutamyl transpeptidase activity is a
leucyltransferase activity is a
leukotriene C4 gamma-glutamyl transferase activity is a
lysyltransferase activity is a
protein-glutamine gamma-glutamyltransferase activity is a
protein-lysine lysyltransferase activity is a
UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity is a
tubulin-tyrosine ligase activity is a
ubiquitin-like protein transferase activity is a
ubiquitinyl hydrolase activity is a
[acyl-carrier-protein] phosphodiesterase activity is a
[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase is a
[protein-PII] uridylyltransferase activity is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a