Purification of wheat germ RNA ligase. II. Mechanism of action of wheat germ RNA ligase

Pick, L.; Furneaux, H.; Hurwitz, J.; J. Biol. Chem. 261, 6694-6704 (1986)

 show all sequences of 6.5.1.3

Data extracted from this reference:

Activating Compound
Activating Compound Commentary Organism Structure
RNA stimulates exchange reaction between ATP and diphosphate Triticum aestivum
Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Triticum aestivum
-
-
-
Purification (Commentary)
Commentary Organism
-
 Triticum aestivum
Reaction
Reaction Commentary Organism
ATP + (ribonucleotide)n + (ribonucleotide)m = AMP + diphosphate + (ribonucleotide)n+m mechanism Triticum aestivum
Source Tissue
Source Tissue Commentary Organism Textmining
germ
-
 Triticum aestivum
-
Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
ATP + (ribonucleotide)n + (ribonucleotide)m poly(A) containing 5'-P-2,3-cyclic P termini 1984 Triticum aestivum AMP + phosphate + (ribonucleotide)n+m
-
 1984 Triticum aestivum
-
dATP + (ribonucleotide)n + (ribonucleotide)m
-
 1984 Triticum aestivum dAMP + phosphate + (ribonucleotide)n+m
-
-
-
-
More RNA-stimulated exchange reaction between ATP and diphosphate 1984 Triticum aestivum ?
-
-
-
-
Activating Compound (protein specific)
Activating Compound Commentary Organism Structure
RNA stimulates exchange reaction between ATP and diphosphate Triticum aestivum
Purification (Commentary) (protein specific)
Commentary Organism
-
 Triticum aestivum
Source Tissue (protein specific)
Source Tissue Commentary Organism Textmining
germ
-
 Triticum aestivum
-
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
ATP + (ribonucleotide)n + (ribonucleotide)m poly(A) containing 5'-P-2,3-cyclic P termini 1984 Triticum aestivum AMP + phosphate + (ribonucleotide)n+m
-
 1984 Triticum aestivum
-
dATP + (ribonucleotide)n + (ribonucleotide)m
-
 1984 Triticum aestivum dAMP + phosphate + (ribonucleotide)n+m
-
-
-
-
More RNA-stimulated exchange reaction between ATP and diphosphate 1984 Triticum aestivum ?
-
-
-
-

See also following references to EC number 6.5.1.3 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
713745ParkDetection of single-base mutat ...Enterobacteria phage T4Anal. Biochem.414303-3052011-------------2--------1-----------------------------------1---------------
714046MakinoUse of domain enzymes from whe ...Triticum aestivumBiochem. Biophys. Res. Commun.4041050-10542011-------------3--------2-----------------------------------2---------------
714026MakinoIn vitro dissection revealed t ...Triticum aestivumBiochem. Biophys. Res. Commun.397762-7662010-------------4--------2-----------------------------------2---------------
716670DurrantNovel naphthalene-based inhibi ...Trypanosoma bruceiPLoS Negl. Trop. Dis.4e8032010--1---8------3--1-----1-----------4--1----48---------1----1----------11---
716756EnglertBranchiostoma floridae has sep ...Branchiostoma floridaeProc. Natl. Acad. Sci. USA10716834-168392010----1--------3--------2-----------------1-----------------2----------11---
694311VicensA natural ribozyme with 3,5 RN ...Anabaena sp.Nat. Chem. Biol.597-992009-----------1-3--------1--------------------------1--------1---------------
707449SilleroSynthesis of ATP derivatives o ...Enterobacteria phage T4Biochem. Pharmacol.78335-3432009-------7-----1------7-7----7-----------------7----------7-7----7--------77
708449SwiftDiscovery and design of DNA an ...Trypanosoma bruceiExpert Opin. Drug Discov.41281-12942009------1------2-----------------------------1------------------------------
694452TorchiaArchaeal RNA ligase is a homod ...Methanothermobacter thermautotrophicusNucleic Acids Res.366218-62272008--1-1--------4--------6211-----------1--1-----------------6211------------
694461NelissenMultiple segmental and selecti ...Enterobacteria phage T4Nucleic Acids Res.36e892008-1-----------4----------------------1-------------------------------------
694881AmaroDiscovery of drug-like inhibit ...Trypanosoma bruceiProc. Natl. Acad. Sci. USA10517278-172832008---1--4------5-------------------------1---4------------------------------
676230RaymondDeinococcus radiodurans RNA li ...Deinococcus radioduransNucleic Acids Res.35839-8492007----22--------3--------------------------22---------------------------------
677101WangThe C-terminal domain of T4 RN ...Enterobacteria phage T4RNA131235-12442007----6--------2--------1-----------------6-----------------1---------------
677128RobertsonThe structural basis of ribozy ...Enterobacteria phage L1Science3151549-15532007---1-----1-1-1--------1----------------1-------1-1--------1---------------
672949NandakumarRNA ligase structures reveal t ...Enterobacteria phage T4Cell12771-842006---1---------2--1----------------------1-------------1--------------------
673669SilleroSynthesis of bisphosphonate de ...Enterobacteria phage T4FEBS Lett.5805723-57272006-------3-----1--------4----3-----------------3------------4----3----------
674568El OmariMolecular architecture and lig ...Enterobacteria phage T4J. Biol. Chem.2811573-15792006--11-----1---3--1--------------------1-1-------1-----1--------------------
676215WangStructure-function analysis of ...Saccharomyces cerevisiaeNucleic Acids Res.34517-5272006--1-23------1-4--------1--------------1--23--------1--------1---------------
677096StarkAn RNA ligase-mediated method ...Enterobacteria phage T4RNA122014-20192006-1-----------1----------------------1-------------------------------------
662976BlondalIsolation and characterization ...Phage TS2126Nucleic Acids Res.33135-1422005-11---12-2---5--1-----1-112-11------11-----1-2-2-----1----1-112-11--------
663245GaoFunctional complementation of ...Leishmania tarentolae, Trypanosoma bruceiProc. Natl. Acad. Sci. USA1024712-47172005--2----------4--------2--------------2--------------------2---------------
653915HoStructure and mechanism of RNA ...Enterobacteria phage T4Structure12327-3392004--11-------1-4--1-----1-----2--------1-1---------1---1----1-----2---------
654015YinCharacterization of bacterioph ...Enterobacteria phage T4, Vibrio phage KVP40Virology319141-1512004--1-------12-5--1-----31----11-------1----------12---1----31----11--------
662241NandakumarRNA substrate specificity and ...Enterobacteria phage T4J. Biol. Chem.27931337-313472004----31----2---3--------1-----------------31------2----------1---------------
662304MartinsAn RNA ligase from Deinococcus ...Deinococcus radioduransJ. Biol. Chem.27950654-506612004----5--------3--------1-----------------5-----------------1---------------
662636DengHigh resolution crystal struct ...Trypanosoma bruceiJ. Mol. Biol.343601-6132004--11-----1-1-4--1-----2--------------1-1-------1-1---1----2---------------
652387YinStructure-function analysis of ...Enterobacteria phage T4J. Biol. Chem.27817601-176082003--1-13------1-2--1-----2-----1--------1--13--------1---1----2-----1---------
652429WangMutational analysis of bacteri ...Enterobacteria phage T4J. Biol. Chem.27829454-294622003--1-31------1-3--1-----1--------------1--31--------1---1----1---------------
653392BlondalDiscovery and characterization ...Rhodothermus phage RM378Nucleic Acids Res.317247-72542003--1---1--211-4--1-----1-1-1-2--------1-----1---211---1----1-1-1-2---------
650172GlasnerMetal ion requirements for str ...synthetic constructBiochemistry418103-81122002--1---10--3-1-2--1-----2------1-------1-----10---3-1---1----2------1--------
650653WangPurification of histidine-tagg ...Enterobacteria phage T4Biotechniques331256-12602002--1--------1-2--1-----1--------------1-----------1---1----1---------------
652246CherepanovKinetic mechanism of the Mg2+- ...Enterobacteria phage T4J. Biol. Chem.2771695-17042002---------1-1-2--1-----2------------------------1-1---1----2---------------
653217Cruz-ReyesDistinct functions of two RNA ...Trypanosoma bruceiMol. Cell. Biol.224652-46602002--------1-11-1--1-----2-----------------------1-11---1----2---------------
653679HoBacteriophage T4 RNA ligase 2 ...Enterobacteria phage T4Proc. Natl. Acad. Sci. USA9912709-127142002--1-6-----11-4--1-----2-----21-------1--6-------11---1----2-----21--------
650982HuangRoles for ligases in the RNA e ...Trypanosoma bruceiEMBO J.204694-47032001--1-2---1--1-3--------2--------------1--2-----1--1--------2---------------
653869McManusIdentification of candidate mi ...Trypanosoma bruceiRNA7167-1752001--1-----1-21-1--1-----2--------------1--------1-21---1----2---------------
653889SchnauferAn RNA ligase essential for RN ...Trypanosoma bruceiScience2912159-21622001-11-----1--1-3--1--1--2-------------11--------1--1---1-1--2---------------
649963BergmanKinetic framework for ligation ...synthetic constructBiochemistry393115-31232000-------------2--------2----7------------------------------2----7----------
651061AtenciaSeveral dinucleoside polyphosp ...Enterobacteria phage T4Eur. J. Biochem.2671707-17142000-------2--11-2--1-----2----------------------2--11---1----2---------------
651051AtenciaT4 RNA ligase catalyzes the sy ...Enterobacteria phage T4Eur. J. Biochem.261802-8111999------1----1-1------1-6----211-------------1-----1------1-6----211--------
653234NishigakiY-ligation: an efficient metho ...Enterobacteria phage T4Mol. Divers.4187-1901998-----------1-2-----1--2--------------------------1-----1--2---------------
653369WangOligoribonucleotide circulariz ...Enterobacteria phage T4Nucleic Acids Res.262502-25041998-----------1-1--------2--------------------------1--------2---------------
1996RuschePurification of a functional e ...Trypanosoma bruceiEMBO J.164069-40811997--------1----3--1-----11----------------------1------1----11--------------
651858PillerTrypanosoma brucei RNA editing ...Trypanosoma bruceiJ. Biol. Chem.2714613-46191996--------1--1-3--------2-----------------------1--1--------2---------------
653368EklandThe secondary structure and se ...synthetic constructNucleic Acids Res.233231-32381995-----------1-2--------1--------------------------1--------1---------------
653882EklandStructurally complex and highl ...synthetic constructScience269364-3701995-------1---1-1--------1----2-----------------1---1--------1----2----------
1910MaundersDNA and RNA ligases (EC 6.5.1. ...Enterobacteria phage T4Methods Mol. Biol.16213-2301993---------11--1-------12------------------------11--------12---------------
2000HaradaIn vitro selection of optimal ...Enterobacteria phage T4Proc. Natl. Acad. Sci. USA901576-15791993-------------1--------2-----------------------------------2---------------
2001IuodaSubstrate specificity of T4 RN ...Enterobacteria phage T4Biokhimiia58857-8651993------7------2--------4--------------------7--------------4---------------
1998Juodka-Inhibition of the first stage ...Enterobacteria phage T4Nucleosides Nucleotides10367-3701991------8------1--------1--------------------8--------------1---------------
1999PickPurification and characterizat ...Triticum aestivumMethods Enzymol.181480-4991990-----2-------2-----1111------------------2-------------1111---------------
1997BakalaraThe Leishmania kinetoplast-mit ...Leishmania tarentolaeJ. Biol. Chem.26418679-186861989--------31-1-3--------3-----------------------31-1--------3---------------
1983PickPurification of wheat germ RNA ...Triticum aestivumJ. Biol. Chem.2616684-66931986-----1---1---2--1--1121---2--------------1-----1-----1-1121---2-----------
1984PickPurification of wheat germ RNA ...Triticum aestivumJ. Biol. Chem.2616694-670419861------------2--11-1--3------------1-----------------1-1--3---------------
1985PerkinsIsolation and characterization ...Homo sapiensProc. Natl. Acad. Sci. USA82684-6881985------1--1---2--1--1112--------------------1---1-----1-1112---------------
1986RandSequence and cloning of bacter ...Enterobacteria phage T4EMBO J.3397-4021984--1----------3--------1--------------1--------------------1---------------
1987FurneauxIsolation and characterization ...Triticum aestivumProc. Natl. Acad. Sci. USA803933-39371983-------2-1---3--1--11-1----------------------2-1-----1-11-1---------------
1988GegenheimerAn RNA ligase from wheat germ ...Triticum aestivumJ. Biol. Chem.2588365-83731983-------------4-----1--1--------------------------------1--1---------------
1989Mei-HaoPurification of T4 RNA ligase ...Enterobacteria phage T4Anal. Biochem.1251-51982-1-----------1--1---111-------------1----------------1--111---------------
1990DolganovA new procedure for the simult ...Enterobacteria phage T4Eur. J. Biochem.114247-2541981-------------3--1--11-1------------------------------1-11-1---------------
1991KonarskaFormation of a 2'-phosphomonoe ...Triticum aestivumNature293112-1161981-------------3-----1--1--------------------------------1--1---------------
1992Moseman McCoyThe Purification of nuclease-f ...Enterobacteria phage T4Biochim. Biophys. Acta562149-1611979-------------3-----11-11-------------------------------11-11--------------
1993SugiuraPurification of T4 RNA ligase ...Enterobacteria phage T4FEBS Lett.9773-761979------1------1--1--11-1--------------------1---------1-11-1---------------
1994LastPurification and properties of ...Enterobacteria phage T4Arch. Biochem. Biophys.174167-1761976----------1--1-------111------------------------1--------111--------------
1995SilberPurification and properties of ...Enterobacteria phage T4Proc. Natl. Acad. Sci. USA693009-30131972-------1-11--1--1---1-3-----1----------------1-11----1--1-3-----1---------