Tryptophanyl adenylate formation by tryptophanyl-tRNA synthetase from Escherichia coli

Merle, M.L.; Trezeguet, V.; Graves, P.; Andrews, D.; Muench, K.H.; Labouesse, B.; Biochemistry 25, 1115-1123 (1986)

 show all sequences of 6.1.1.2

Data extracted from this reference:

KM Value [mM]
KM Value [mM] KM Value Maximum [mM] Substrate Commentary Organism Structure
additional information
-
 additional information kinetic behavior in adenylation Escherichia coli
-
Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Escherichia coli
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-
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Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
ATP + L-tryptophan + tRNATrp
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 305 Escherichia coli AMP + diphosphate + L-tryptophan-tRNATrp
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 305 Escherichia coli
-
KM Value [mM] (protein specific)
KM Value [mM] KM Value Maximum [mM] Substrate Commentary Organism Structure
additional information
-
 additional information kinetic behavior in adenylation Escherichia coli
-
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
ATP + L-tryptophan + tRNATrp
-
 305 Escherichia coli AMP + diphosphate + L-tryptophan-tRNATrp
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 305 Escherichia coli
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See also following references to EC number 6.1.1.2 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
716156MerrittCrystal structures of three pr ...Cryptosporidium parvum, Entamoeba histolytica, Trypanosoma bruceiMol. Biochem. Parasitol.17720-282011--131---22-2-10--------533---3--2-----1251-----42-2--------755---5----35---
702375WakasugiAn exposed cysteine residue of ...Homo sapiensBiochemistry493156-31602010111-1----1-1-3--1-----1-1---1--1---1111-1------1-1---1----1-1---1---------
703734WakasugiSpecies-specific differences i ...Bos taurus, Homo sapiens, Mus musculusFEBS Lett.584229-23220104-3-4----2-3-7--3-----3-3----3-3---4-33-4------2-3---3----3-3----3--------
705840HjelmExploring epitopes of antibodi ...Homo sapiensN. Biotechnol.27129-1372010--1-----2-21-4--1--4--1--------1-----11-------2-21---1-4--1---------------
705874ZhouOrthogonal use of a human tRNA ...Homo sapiensNat. Struct. Mol. Biol.1757-612010----4------1-3--------2--------1------1-4--------1--------2---------------
705981DongCrystal structure of Pyrococcu ...Pyrococcus horikoshiiNucleic Acids Res.381401-14122010--11-------1-2--1-----1--------1-----111---------1---1----1---------------
706666BhattacharyyaAllostery and conformational f ...Homo sapiensProteins78506-5172010-----------1-3--------1--------1------1----------1--------1---------------
715366VecchioneRegulation of an auxiliary, an ...Streptomyces avermitilis, Streptomyces coelicolorJ. Bacteriol.1923565-35732010--2-4-2------7-----------------------2--4--2-------------------------11---
716055ArakakiThe structure of tryptophanyl- ...Giardia intestinalisJ. Struct. Biol.171238-2432010---1-----1-1-5--------31-------1------11-------1-1--------31---------11---
716370ZhouCrystal structures of Saccharo ...Saccharomyces cerevisiaeNucleic Acids Res.383399-34132010--11-----1-1-4--1-----21-------1-----111-------1-1---1----21---------11---
716373HughesRational design of an orthogon ...Escherichia coliNucleic Acids Res.386813-68302010-1--1--------5----------------------1---1----------------------------11---
701740VecchioneA novel tryptophanyl-tRNA synt ...Streptomyces coelicolor, Streptomyces griseusAntimicrob. Agents Chemother.533972-39802009-21-12-2----2-2--------2--------2----212-12--2-----2--------2---------------
703001GhanipourThe prognostic significance of ...Homo sapiensCancer Epidemiol. Biomarkers Prev.182949-29562009-1--------11-3-----1--1--------1----1-1---------11-----1--1----------11---
704353TsuchiyaMolecular recognition of trypt ...Aeropyrum pernix K1J. Biochem.145635-6412009--1----23---1-3--1-----23-1--231--1-----11------23---1---1----23-1--231---------
705647HansiaLigand dependent intra and int ...Homo sapiensMol. Biosyst.51860-18722009-----------1-3--------11-------1------1----------1--------11--------------
691148AzimDocking of tryptophanyl [corre ...Escherichia coliBiol. Chem.3891173-11822008-1-----------3--------20-------------1---------------------20---------------
692756WeinrebMg2+-free Bacillus stearotherm ...Geobacillus stearothermophilusJ. Am. Chem. Soc.1301488-14942008---------1---3---1------1---1------------------1------------1---1---------
694430ShenCatalytic mechanism of the try ...Homo sapiensNucleic Acids Res.361288-12992008---1---------3---1-----1---------------1-------------------1--------------
695285Rajendran-Molecular phylogenetic analysi ...Aggregatibacter actinomycetemcomitansZ. Naturforsch. C63418-4282008--1----------1-----------------------1------------------------------------
704281VecchioneCharacterization of an inducib ...Streptomyces coelicolorJ. Bacteriol.1906253-625720084---1-1----1-2--------1--------1---4--2-2--1-----2--------2---------------
672219WakasugiHuman tryptophanyl-tRNA synthe ...Homo sapiensBiochemistry4611291-1129820072-1-12-1--3-1-3--1--1--2-1---1--1---2-11-12--1---3-1---1-1--2-1---1---------
674218WuPotent and selective inhibitor ...Staphylococcus epidermidisJ. Antimicrob. Chemother.60502-5092007------4--1-1-4--------2-1---1--1--6---1---64---1-1--------2-1---1---------
675928PhamA minimal TrpRS catalytic doma ...Geobacillus stearothermophilusMol. Cell25851-8622007--1-2----1-1-2--1-1-1-21-------1-----11-2------1-1---11-1-21--------------
676170PaleyTryptamine induces tryptophany ...Homo sapiens, Mus musculusNeuroMol. Med.955-8220072-----4--2-4-6-----3--422---2--2---2--2----4---2-4-----3--422---2---------
676229GuoHuman tryptophanyl-tRNA synthe ...Homo sapiensNucleic Acids Res.355934-59432007--1-10--9-1-1-3------1-211--101--1-----11-10----9-1-1------1-211--101---------
673324YangTwo conformations of a crystal ...Homo sapiensEMBO J.252919-29292006---11----1-1-3--------311---1--1------111------1-1--------311---1---------
675401KapustinaComputational studies of trypt ...Geobacillus stearothermophilusJ. Mol. Biol.3621159-11802006----11---1-1-3--------31-------1------1-11-----1-1--------31--------------
676210ShenStructure of human tryptophany ...Homo sapiensNucleic Acids Res.343246-32582006--1120--2-1-1-3------1-2-1--11--1-----11120----2-1-1------1-2-1--11---------
676863CharriereDual targeting of a single tRN ...Trypanosoma bruceiProc. Natl. Acad. Sci. USA1036847-68522006--1-----31-1-3--1-----2--------1-----11-------31-1---1----2---------------
661186WakasugiOxidative stress-responsive in ...Homo sapiensBiochemistry44225-23220051-------1----3--------1------------1----------1-----------1---------------
661390BoassoRegulation of indoleamine 2,3- ...Homo sapiensBlood1051574-15812005-----------1-1-----2--1--------------------------1-----2--1---------------
662375TzimaVE-cadherin links tRNA synthet ...Homo sapiensJ. Biol. Chem.2802405-24082005-----------1-2-----1--1--------------------------1-----1--1---------------
662405BuddhaStructures of tryptophanyl-tRN ...Deinococcus radioduransJ. Biol. Chem.28031965-319732005---1---------5-------------------------1----------------------------------
652565YuCrystal structure of human try ...Homo sapiensJ. Biol. Chem.2798378-83882004---1-------2-4-1-1----2--------1------11---------2--1-----2---------------
653395LiuA new gamma-interferon-inducib ...Homo sapiensNucleic Acids Res.32719-72720042-1--------2-3-----3--3--------1---2-11----------2-----3--3---------------
662273JiaResidues Lys-149 and Glu-153 s ...Bacillus subtilisJ. Biol. Chem.27941960-419652004----7--22-----4--1-----1----20------------7----22-------1----1----20----------
662935KiseA short peptide insertion cruc ...Homo sapiensNat. Struct. Mol. Biol.11149-1562004--111---1----3--1--3-----------------1-11-----1------1-3------------------
663219BuddhaAn unusual tryptophanyl tRNA s ...Deinococcus radioduransProc. Natl. Acad. Sci. USA10115881-158862004--1--------1-5--1-----1--------------1-----------1---1----1---------------
663230ZhangSelective incorporation of 5-h ...Bacillus subtilisProc. Natl. Acad. Sci. USA1018882-88872004----1--------4--------2-----------------1-----------------2---------------
663440YangRelationship of two human tRNA ...Homo sapiensTrends Biochem. Sci.29250-2562004---1---------3-------------------------1----------------------------------
652900RetailleauInterconversion of ATP binding ...Geobacillus stearothermophilusJ. Mol. Biol.32539-632003---1--11-1-1-2---1----211---1--1------11---1-1-1-1--------211---1---------
653590YangCrystal structures that sugges ...Homo sapiensProc. Natl. Acad. Sci. USA10015376-153802003---1-------1-2---1----1--------1------11---------1--------1---------------
649736JiaTwo essential regions for tRNA ...Bacillus subtilisBiochem. J.365749-7562002--1-1--6---1-3--11----3-2--81--1-----11-1----6---1---1----3-2--81---------
650116EwaltActivation of angiogenic signa ...Homo sapiensBiochemistry4113344-1334920021----------2-1-1---9--3--------1---1--1----------2--1--9--3---------------
650171XuThree G.C base pairs required ...Bacillus subtilisBiochemistry418087-80922002----1--1-1-1-3--------2-1---1--1------1-1----1-1-1--------2-1---1---------
650562BrownThe antimicrobial natural prod ...Staphylococcus aureusBioorg. Med. Chem. Lett.123171-31742002-1----6----1-1--------2--------11---1-1----61----1--------2---------------
651316ZunigaA dispensable peptide from Aci ...Acidithiobacillus ferrooxidans, Escherichia coliFEBS Lett.532387-3902002--2----8---2-5--------2----7---2-----22------8---2--------2----7----------
653740XuHigh-level expression and sing ...Homo sapiensProtein Expr. Purif.23296-3002001--1----3-1-1-3--1---1-1-1--31--1-----11------3-1-1---1--1-1-1--31---------
651999JorgensenIdentification and characteriz ...Homo sapiensJ. Biol. Chem.27516820-168262000--1----22--1-4--1-----211--21--1-----11------22--1---1----211--21---------
650759PaleyTryptamine-mediated stabilizat ...Homo sapiensCancer Lett.1371-71999-----11----1-4-1---2--1--------1------1--1-1-----1--1--2--1---------------
653177SeshaiahWRS-85D: A tryptophanyl-tRNA s ...Drosophila melanogasterMol. Biol. Cell101595-16081999--1--------1-4--1--6--2-1---1--1-----11----------1---1-6--2-1---1---------
653176Ivanova-Distribution of tryptophanyl-t ...Homo sapiensMol. Biol.32736-74219981-------4--1-1-----1--1--------1---1--1-------4--1-----1--1---------------
292HogueA concerted tryptophanyl-adeny ...Bacillus subtilisJ. Mol. Biol.260446-4661996---1---------4--------1----------------1------------------1---------------
125GoldgurAminoacyl-tRNA synthetases fro ...Haloarcula marismortuiBiochem. Mol. Biol. Int.321075-10831994-------------1---------1-----------------------------------1--------------
290MerkulovaP1,P3-bis(5'-adenosyl)triphosp ...Bos taurusFEBS Lett.350287-2901994-------2---2-3-----1--6----------------------2---2-----1--6---------------
293Carter Jr.Quantitative analysis of cryst ...Geobacillus stearothermophilusJ. Mol. Biol.238346-3651994---1---------3--------1----------------1------------------1---------------
288KisselevMammalian tryptophanyl-tRNA sy ...Bos taurus, Homo sapiens, Mammalia, Mus musculus, Oryctolagus cuniculus, Ovis aries, Primates, Rattus norvegicus, Rodentia, RuminantiaBiochimie751027-10391993--4------2-4-14-----6--14--------------4---------2-4-----6--14---------------
291AlaCrystallization of Bacillus su ...Bacillus subtilisJ. Mol. Biol.2301089-10901993--11---------3--------1--------------1-1------------------1---------------
289ChowMutational identification of a ...Bacillus subtilisJ. Biol. Chem.2679146-91491992--1-3--------3--1-----2--------------1--3------------1----2---------------
307FournierBinding stoichiometry of tRNAT ...Bos taurusBiochim. Biophys. Acta916350-3571987-------------3-----2--2-----1--------------------------2--2-----1---------
305MerleTryptophanyl adenylate formati ...Escherichia coliBiochemistry251115-11231986-------1-----3--------1----------------------1------------1---------------
306SallafranqueTryptophanyl-tRNA synthetase i ...Bos taurusBiochim. Biophys. Acta882192-1991986-----------2-3-----11--3--------------------------2-----11--3---------------
304AndrewsTryptophanamide formation by E ...Escherichia coliEur. J. Biochem.146201-2091985-------1-----3--------2----1-----------------1------------2----1----------
303ColemanCrystals of Bacillus stearothe ...Geobacillus stearothermophilusBiochemistry23381-3851984---1---------3--------1----------------1------------------1---------------
302CarterUse of chromatofocusing in the ...Geobacillus stearothermophilusAnal. Biochem.124327-3321982-------------2--1----11------------------------------1---11---------------
301KisselevBovine tryptophanyl-tRNA synth ...Bos taurusEur. J. Biochem.120511-5171981------1--1---3--------1--------------------1---1----------1---------------
299Kisselev-Tryptophanyl-tRNA synthetase f ...Bos taurusMethods Enzymol.54234-2571979-----1363--1--1--1--11311-----------------1-36-3--1----1-11311--------------
300DrocourtBlue dextran Sepharose chromat ...Escherichia coliNucleic Acids Res.62919-29281979-------1-----2--1-----1----------------------1-------1----1---------------
298WinterSequence homologies between th ...Escherichia coli, Geobacillus stearothermophilusFEBS Lett.82348-3501977----------2--2--------2-------------------------2---------2---------------
297WernerIndolmycin inhibits prokaryoti ...Escherichia coli, Rattus norvegicusEur. J. Biochem.681-31976------2------2-----1--2--------------------2-----------1--2---------------
85JakubowskiThe plant aminoacyl-tRNA synth ...Lupinus luteusEur. J. Biochem.52301-3101975-----133-21--3--1--11121----4------------1-3-3-21----1-11121----4---------
294LemaireMultiple forms of tryptophanyl ...Bos taurusEur. J. Biochem.51237-2521975-------9--4--3--1--2-121---------------------9--4----1-2-121--------------
296FavorovaKinetic parameters of tryptoph ...Bos taurusFEBS Lett.56322-3261975-------1-----1-----1--2----------------------1---------1--2---------------