The squalene epoxide-cyclase activity of human term placenta

Tabacik, C.; Descomps, B.; Crastles de Paulet, A.; FEBS Lett. 34, 238-242 (1973)

 show all sequences of 5.4.99.7

Data extracted from this reference:

Activating Compound
Activating Compound Commentary Organism Structure
Rat liver cytosol carrier protein enhances lanosterol synthase activity in placental microsomes Homo sapiens
Localization
Localization Commentary Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-
Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue Commentary Organism Textmining
placenta
-
 Homo sapiens
-
Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
(S)-squalene-2,3-epoxide
-
 3593 Homo sapiens Lanosterol
-
 3593 Homo sapiens
-
Activating Compound (protein specific)
Activating Compound Commentary Organism Structure
Rat liver cytosol carrier protein enhances lanosterol synthase activity in placental microsomes Homo sapiens
Localization (protein specific)
Localization Commentary Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-
Source Tissue (protein specific)
Source Tissue Commentary Organism Textmining
placenta
-
 Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
(S)-squalene-2,3-epoxide
-
 3593 Homo sapiens Lanosterol
-
 3593 Homo sapiens
-

See also following references to EC number 5.4.99.7 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
716408WuMutation of isoleucine 705 of ...Saccharomyces cerevisiaeOrg. Biomol. Chem.91092-10972011----20--------2--------1-----------------20-----------------1---------------
702462TaraminoInteractions of oxidosqualene ...Saccharomyces cerevisiaeBiochim. Biophys. Acta1801156-1622010-------------5--------2-----------------------------------2---------------
703517JoffrionFunctional characterization an ...Pneumocystis cariniiEukaryot. Cell9107-1152010--1-----1-1--4--1-----1--------------1--------1-1----1----1---------------
706053WuAlteration of the substrates p ...Saccharomyces cerevisiaeOrg. Lett.12500-5032010----8--------3--------1-----------------8-----------------1---------------
711300TaraminoDivergent interactions involvi ...Homo sapiens, Saccharomyces cerevisiaeBiochim. Biophys. Acta18011232-123720102----------2-7-----1--2------------2-------------2-----1--2---------------
714021KimuraProtostadienol synthase from A ...Aspergillus fumigatusBiochem. Biophys. Res. Commun.391899-9022010--1-1--------4--------1--------------1--1-----------------1---------------
714529ShangMolecular cloning, characteriz ...Ganoderma lucidumBiosci. Biotechnol. Biochem.74974-9782010--1----------4-----1--1--------------1-----------------1--1---------1--1--
693249DangSuppression of 2,3-oxidosquale ...Mus musculus, Rattus norvegicusJ. Biol. Chem.2846218-62262009------3-2----4-----2--4--------------------3--2--------2--4---------------
694920OhyamaDual biosynthetic pathways to ...Arabidopsis thalianaProc. Natl. Acad. Sci. USA106725-73020091------------3-----1--1------------1-------------------1--1---------------
703083SeikiPharmacologic inhibition of sq ...MetazoaCardiol. Rev.1770-762009------1----1-2--------1--------------------1-----1--------1----------11---
703421Duniec-DmuchowskiHuman pregnane X receptor acti ...Homo sapiensDrug Metab. Dispos.37900-9082009------3------3-----3--1--------------------3-----------3--1---------------
691073TeskeGenetic analyses involving int ...Saccharomyces cerevisiaeBiochim. Biophys. Acta1781359-36620081------------3--------1------------1----------------------1---------------
691228FouchetDesign and evaluation of a nov ...Homo sapiensBioorg. Med. Chem.166218-62322008------22-1----3-----1--2-----------19-------1922--1--------1--2---------------
691772WuSaccharomyces cerevisiae oxido ...Saccharomyces cerevisiaeChem. Rec.8302-3252008----7-3------3--------2-----------------7--3--------------2---------------
694523WuProtein plasticity: a single a ...Saccharomyces cerevisiaeOrg. Lett.102529-25322008----5--------3--------1-----------------5-----------------1---------------
694526WuImportance of Saccharomyces ce ...Saccharomyces cerevisiaeOrg. Lett.104959-49622008--1-19--------2--------1--------------1--19-----------------1---------------
678654GalliDesign, synthesis, and biologi ...Homo sapiens, Pneumocystis carinii, Saccharomyces cerevisiae, Trypanosoma cruziBioorg. Med. Chem. Lett.17220-2242007--3---12------7--------------------11--3----1112------------------------------
678806NakanoSterol biosynthesis by a proka ...Methylococcus capsulatusBiosci. Biotechnol. Biochem.712543-25502007--1----------4--------11-------------1--------------------11--------------
681842LambLanosterol biosynthesis in the ...Methylococcus capsulatusMol. Biol. Evol.241714-17212007--1-----1----3--------11-------------1--------1-----------11--------------
662517MoriLanosterol synthase mutations ...Rattus norvegicusJ. Clin. Invest.116395-4042006-11-3---1--1-4-----22-2-------------11--3-----1--1-----22-2---------------
663010LodeiroA putative precursor of isomal ...Saccharomyces cerevisiaeOrg. Lett.8439-4422006--1-2------1-2--------1--------------1--2--------1--------1---------------
677804KolesnikovaLanosterol biosynthesis in pla ...Arabidopsis thalianaArch. Biochem. Biophys.44787-952006--1----------2--------1--------------1--------------------1---------------
680354WuSite-saturated mutagenesis of ...Saccharomyces cerevisiaeJ. Am. Chem. Soc.1286414-64192006----19--------2---1----1-----------------19-----------------1---------------
681517Tanaka-Constituents of Laurus nobilis ...Homo sapiensJ. Nat. Med.6078-812006------2------1-----------------------------2------------------------------
682229WuTryptophan 232 within oxidosqu ...Saccharomyces cerevisiaeOrg. Lett.81319-13222006----19--------2---1----1-----------------19-----------------1---------------
682232WuPhenylalanine 445 within oxido ...Saccharomyces cerevisiaeOrg. Lett.84691-46942006----6--------2--------1-----------------6-----------------1---------------
682342SuzukiLanosterol synthase in dicotyl ...Arabidopsis thalianaPlant Cell Physiol.47565-5712006--1-1--------5-----3-----------------1--1--------------3------------------
682344SawaiPlant lanosterol synthase: div ...Lotus japonicusPlant Cell Physiol.47673-6772006----1--------3--------1-----------------1-----------------1---------------
661036VenteclefThe imidazoline-like drug S235 ...Homo sapiens, Macaca fascicularis, Rattus norvegicusBiochem. Pharmacol.691041-10482005-3----6----3-3-----5--6---------1---3------61----3-----5--6---------------
661306SakanoInhibition of human lanosterol ...Homo sapiensBiol. Pharm. Bull.28299-3042005--1---12----1-3--1-----1--------------1-----12-----1---1----1---------------
661342TanakaSynthesis of digalactosyl diac ...Homo sapiensBioorg. Med. Chem. Lett.15159-1622005-1----16------3--------1-------------1------16--------------1---------------
661489Oliaro-BossoAccess of the substrate to the ...Saccharomyces cerevisiaeChemBioChem62221-22282005--11612----1-5------13-2--------------1-161-2-----1------13-2---------------
663443HuffLord of the rings--the mechani ...Homo sapiens, Sus scrofaTrends Pharmacol. Sci.26335-3402005-2-2--4----2-2--------42------------2--2---4-----2--------42--------------
649491WuPurification, tandem mass char ...Bos taurusArch. Biochem. Biophys.42142-532004------613-1--5--1--1111111--11----5-------56-13-1----1-1111111--11--------
649634RufThe monotopic membrane protein ...Homo sapiensBiochem. Biophys. Res. Commun.315247-2542004-111--1-1-11-4-11----121----------2-11-1--21--1-11--11---121--------------
661482WuEnzymatic formation of multipl ...Saccharomyces cerevisiaeChemBioChem51712-17152004--1-5------1-2--------1--------------1--5--------1--------1---------------
662756Oliaro-BossoUmbelliferone aminoalkyl deriv ...Pneumocystis carinii, Saccharomyces cerevisiae, Trypanosoma cruziLipids391007-10122004-33---30-3--3-6--------3---------27---33-----3027-3--3--------3---------------
662943ThomaInsight into steroid scaffold ...Homo sapiensNature432118-1222004-111--1-1--1-3--------1-------------11-1---1--1--1--------1---------------
652746DehmlowSynthesis and structure-activi ...Homo sapiensJ. Med. Chem.463354-33702003------21------4--------------------21-------2121------------------------------
652750HinshawOxidosqualene cyclase inhibito ...Pneumocystis carinii, Rattus norvegicus, Trypanosoma brucei, Trypanosoma cruziJ. Med. Chem.464240-42432003------16------8--------------------12-------1216------------------------------
652611Ceruti-Synthesis of (E)- and (Z)-29-m ...Saccharomyces cerevisiae, Sus scrofaJ. Chem. Soc. Perkin Trans.11477-14862002------20------2--------------------20-------2020------------------------------
440042CerutiVinyl sulfide derivatives of t ...Saccharomyces cerevisiae, Sus scrofaLipids36629-6362001------14------5--------------------14-------1414------------------------------
653404JoubertTrypanosome and animal lanoste ...Trypanosoma cruziOrg. Lett.31957-19602001--1----------3--------1--------------1--------------------1---------------
650545ViolaStereospecific syntheses of tr ...Saccharomyces cerevisiae, Sus scrofaBioorg. Med. Chem.8223-2322000------16------4--------------------16-------1616------------------------------
652725BrownA novel series of 4-piperidino ...Homo sapiens, Rattus norvegicusJ. Med. Chem.434964-49722000------15-1----4--------------------10-------1015--1---------------------------
652717BrownQuinuclidine inhibitors of 2,3 ...Homo sapiens, Rattus norvegicusJ. Med. Chem.421306-13111999------8-1----4--------------------2-------28--1---------------------------
3615Ceruti9-Methylidine-2,3-oxidosqualen ...Saccharomyces cerevisiae, Sus scrofaJ. Med. Chem.41540-5541998------13------5-----2--2-----------13-------1313-----------2--2---------------
650904CattelInhibitors of 2,3-oxidosqualen ...Candida albicans, Canis lupus familiaris, Rattus norvegicus, Saccharomyces cerevisiae, Sus scrofaCrit. Rev. Biochem. Mol. Biol.33353-3731998------31-2-3--5--5-----------------26-------2631--2-3----5--------------------
3614StachSynthesis and inhibition studi ...Candida albicans, Rattus norvegicus, Sus scrofaJ. Med. Chem.40201-2091997------3------7-----2--3--------------------3-----------2--3---------------
3607Abad2,3,18,19-Dioxidosqualene ster ...Sus scrofaJ. Org. Chem.617603-76071996------1------2-----2--1--------------------1-----------2--1---------------
3613BarthStructural and stereoelectroni ...Rattus norvegicusJ. Med. Chem.392302-23121996------1-1----3-----2--1--------------------1--1--------2--1---------------
3608Cattel2,3-Oxidosqualene cyclase: fro ...Candida albicans, Rattus norvegicus, Saccharomyces cerevisiae, Sus scrofaLipids30235-2461995------18-4----7-----2--4--------------------18--4--------2--4---------------
3609ViolaInhibition of 2,3-oxidosqualen ...Candida albicans, Homo sapiens, Rattus norvegicus, Saccharomyces cerevisiae, Sus scrofaBiochem. Pharmacol.50787-7961995------15-2----8-----4--5--------------------15--2--------4--5---------------
3617AbeMolecular cloning, characteriz ...Rattus norvegicusProc. Natl. Acad. Sci. USA929274-92781995--1----------5--------1--------------1--------------------1---------------
3592ShiIsolation and characterization ...Saccharomyces cerevisiaeProc. Natl. Acad. Sci. USA917370-73741994--1---1------5--------11-------------1-----1--------------11--------------
3599CoreyMolecular cloning, characteriz ...Saccharomyces cerevisiaeProc. Natl. Acad. Sci. USA912211-22151994--1----------4--------11-------------1--------------------11--------------
3591BallianoDifferential inhibition of fun ...Candida albicans, Saccharomyces cerevisiaeFEBS Lett.320203-2061993------2-4----4-----2--2--------------------2--4--------2--2---------------
3605BallianoCharacterization and partial p ...Saccharomyces cerevisiaeArch. Biochem. Biophys.293122-1291992-------11--1-1--1---1-2----------------------11--1---1--1-2---------------
3612WannamakerN-(1-Oxododecyl)-4alpha,10-dim ...Rattus norvegicusJ. Med. Chem.353581-35831992------1------1-----1--1--------------------1-----------1--1---------------
3616MoorePurification of 2,3-oxidosqual ...Rattus norvegicusJ. Biol. Chem.26722003-220061992-------11----3--1--21-11---------------------11------1-21-11--------------
3603Hoshino-Partial purification and chara ...Saccharomyces cerevisiaeTetrahedron475925-593219911-----4-11---1--1---1-1-----1------1-------4--11-----1--1-1-----1---------
3604Corey-Purification of the 2,3-oxidos ...Saccharomyces cerevisiaeJ. Am. Chem. Soc.1138172-81741991-------------1--1---1111-----------------------------1--1111--------------
3611KusanoPurification and some properti ...Rattus norvegicusChem. Pharm. Bull.39239-24119911-----211----1-----11-21-----------1-------2-11--------11-21--------------
3606KellyCloning and characterization o ...Candida albicansGene87177-1831990--1--------1-1--------2--------------1-----------1--------2---------------
3610JolidonInhibitors of 2,3-oxidosqualen ...Candida albicans, Rattus norvegicusBiochem. Soc. Trans.1847-481990------6------2-----1--2--------------------6-----------1--2---------------
3600DuriattiPartial purification of 2,3-ox ...Sus scrofaBiochem. Biophys. Res. Commun.1511378-13851988------1-1----2--1--11111-------------------1--1------1-11111--------------
3601BallianoInhibition of sterol biosynthe ...Saccharomyces cerevisiaeBiochim. Biophys. Acta9599-191988------2-2----2--------1--------------------2--2-----------1---------------
3598TatonN-[(1,5,9)-Trimethyl-decyl]-4a ...Rattus norvegicusBiochem. Biophys. Res. Commun.138764-7701986------1-1----1-----1--1--------------------1--1--------1--1---------------
3597ChenChloroquine inhibits cyclizati ...Mus musculusJ. Biol. Chem.2598156-81621984------1------3-----1--1--------------------1-----------1--1---------------
3602RohmerNon-specific lanosterol and ho ...Methylococcus capsulatusEur. J. Biochem.112557-5601980-------------1--------3-----------------------------------3---------------
3596ChangInhibition of cholesterol bios ...Mesocricetus auratusJ. Biol. Chem.25411258-112631979------1------2-----2--1--------------------1-----------2--1---------------
438197AstrucSqualene epoxidase and oxidosq ...Rattus norvegicusBiochim. Biophys. Acta487204-2111977-------------1-----7--1--------------------------------7--1---------------
3594SaatEffect of a supernatant protei ...Rattus norvegicusJ. Biol. Chem.2515155-516019761-------1----4-----1--1------------1----------1--------1--1---------------
3593TabacikThe squalene epoxide-cyclase a ...Homo sapiensFEBS Lett.34238-24219731-------1----2-----2--1------------1----------1--------2--1---------------
3590YamamotoSome properties of the microso ...Sus scrofaProc. Natl. Acad. Sci. USA63110-11719691-----111-1--1--1--1-11------------1-------1-11-1----1-1-11---------------
3588WillettSqualene-2,3-oxide, an interme ...Rattus norvegicusJ. Biol. Chem.2424182-41911967--------1----1-----1--1-----------------------1--------1--1---------------
3589DeanA soluble 2,3-oxidosqualene st ...Sus scrofaJ. Biol. Chem.2423014-30151967-----12-1----1--1--1111------------------1-2--1------1-1111---------------