Identification and characterization of novel uroporphyrinogen decarboxylase gene mutations in a large series of porphyria cutanea tarda patients and relatives

Badenas, C.; To-Figueras, J.; Phillips, J.D.; Warby, C.A.; Munoz, C.; Herrero, C.; Clin. Genet. 75, 346-353 (2009)

Data extracted from this reference:

Cloned(Commentary)

Commentary	Organism
expression in Escherichia coli	Homo sapiens

Engineering

Amino acid exchange	Commentary	Organism
A22V	soluble but reduced catalytic activity	Homo sapiens
D79N	misfolded protein that is trafficked to inclusion bodies	Homo sapiens
F84I	soluble but reduced catalytic activity	Homo sapiens
M1I	the absence of an initial methionine codon within the messenger RNA (mRNA) Kozac consensus sequence is predicted to lead to a loss of translation from the mutant allele	Homo sapiens
additional information	5del10, this may yield a truncated protein of 115 amino acids or nonsense-mediated mRNA decay	Homo sapiens
P150L	misfolded protein that is trafficked to inclusion bodies	Homo sapiens
Q116X	this may yield a truncated protein of 115 amino acids or nonsense-mediated mRNA decay	Homo sapiens
T141I	soluble but reduced catalytic activity	Homo sapiens
Y182C	soluble but reduced catalytic activity	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Commentary	Organism
42000	-	SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Commentary (Nat. Sub.)	Natural Products	Commentary (Nat. Pro.)	Organism (Nat. Pro.)	Reversibility
uroporphyrinogen-III	Homo sapiens	-	coproporphyrinogen-III + 4CO2	-	-	?

Organism

Organism	Primary Accession No. (UniProt)	Commentary	Textmining
Homo sapiens	P06132	-	-

Purification (Commentary)

Commentary	Organism
Ni-NTA column	Homo sapiens

Source Tissue

Source Tissue	Commentary	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [ľmol/min/mg]	Specific Activity Maximum [ľmol/min/mg]	Commentary	Organism
additional information	-	recombinant mutant A22V substrate uroporphyrinogen-I, 62.6% of recombinant wild-type activity; recombinant mutant A22V substrate uroporphyrinogen-III, 73.2% of recombinant wild-type activity; recombinant mutant F84I substrate uroporphyrinogen-I, 1.7% of recombinant wild-type activity; recombinant mutant F84I substrate uroporphyrinogen-III, 2.3% of recombinant wild-type activity; recombinant mutant T141I substrate uroporphyrinogen-I, 21.3% of recombinant wild-type activity; recombinant mutant T141I substrate uroporphyrinogen-III, 26.7% of recombinant wild-type activity; recombinant mutant Y182C substrate uroporphyrinogen-I, 40.0% of recombinant wild-type activity; recombinant mutant Y182C substrate uroporphyrinogen-III, 65.2% of recombinant wild-type activity	Homo sapiens

Substrates and Products (Substrate)

Substrates	Commentary Substrates	Literature (Substrates)	Organism	Products	Commentary (Products)	Literature (Products)	Organism (Products)	Reversibility
pentacarboxylic porphyrinogen I	-	703279	Homo sapiens	coproporphyrinogen-I + 4CO2	-	-	-	?
uroporphyrinogen-I	-	703279	Homo sapiens	coproporphyrinogen-I + 4CO2	-	-	-	?
uroporphyrinogen-III	-	703279	Homo sapiens	coproporphyrinogen-III + 4CO2	-	-	-	?

Cloned(Commentary) (protein specific)

Commentary	Organism
expression in Escherichia coli	Homo sapiens

Engineering (protein specific)

Amino acid exchange	Commentary	Organism
A22V	soluble but reduced catalytic activity	Homo sapiens
D79N	misfolded protein that is trafficked to inclusion bodies	Homo sapiens
F84I	soluble but reduced catalytic activity	Homo sapiens
M1I	the absence of an initial methionine codon within the messenger RNA (mRNA) Kozac consensus sequence is predicted to lead to a loss of translation from the mutant allele	Homo sapiens
additional information	5del10, this may yield a truncated protein of 115 amino acids or nonsense-mediated mRNA decay	Homo sapiens
P150L	misfolded protein that is trafficked to inclusion bodies	Homo sapiens
Q116X	this may yield a truncated protein of 115 amino acids or nonsense-mediated mRNA decay	Homo sapiens
T141I	soluble but reduced catalytic activity	Homo sapiens
Y182C	soluble but reduced catalytic activity	Homo sapiens

Molecular Weight [Da] (protein specific)

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Commentary	Organism
42000	-	SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates) (protein specific)

Natural Substrates	Organism	Commentary (Nat. Sub.)	Natural Products	Commentary (Nat. Pro.)	Organism (Nat. Pro.)	Reversibility
uroporphyrinogen-III	Homo sapiens	-	coproporphyrinogen-III + 4CO2	-	-	?

Purification (Commentary) (protein specific)

Commentary	Organism
Ni-NTA column	Homo sapiens

Source Tissue (protein specific)

Source Tissue	Commentary	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Specific Activity [micromol/min/mg] (protein specific)

Specific Activity Minimum [ľmol/min/mg]	Specific Activity Maximum [ľmol/min/mg]	Commentary	Organism
additional information	-	recombinant mutant A22V substrate uroporphyrinogen-I, 62.6% of recombinant wild-type activity; recombinant mutant A22V substrate uroporphyrinogen-III, 73.2% of recombinant wild-type activity; recombinant mutant F84I substrate uroporphyrinogen-I, 1.7% of recombinant wild-type activity; recombinant mutant F84I substrate uroporphyrinogen-III, 2.3% of recombinant wild-type activity; recombinant mutant T141I substrate uroporphyrinogen-I, 21.3% of recombinant wild-type activity; recombinant mutant T141I substrate uroporphyrinogen-III, 26.7% of recombinant wild-type activity; recombinant mutant Y182C substrate uroporphyrinogen-I, 40.0% of recombinant wild-type activity; recombinant mutant Y182C substrate uroporphyrinogen-III, 65.2% of recombinant wild-type activity	Homo sapiens

Substrates and Products (Substrate) (protein specific)

Substrates	Commentary Substrates	Literature (Substrates)	Organism	Products	Commentary (Products)	Literature (Products)	Organism (Products)	Reversibility
pentacarboxylic porphyrinogen I	-	703279	Homo sapiens	coproporphyrinogen-I + 4CO2	-	-	-	?
uroporphyrinogen-I	-	703279	Homo sapiens	coproporphyrinogen-I + 4CO2	-	-	-	?
uroporphyrinogen-III	-	703279	Homo sapiens	coproporphyrinogen-III + 4CO2	-	-	-	?

See also following references to EC number 4.1.1.37 (sorted by year of publication):

No.	1st author	Pub Med	title	organims	journal	volume	pages	year	Activating Compound	Application	Cloned(Commentary)	Crystallization (Commentary)	Engineering	General Stability	Inhibitors	KM Value [mM]	Localization	Metals/Ions	Molecular Weight [Da]	Natural Substrates/ Products (Substrates)	Organic Solvent Stability	Organism	Oxidation Stability	Posttranslational Modification	Purification (Commentary)	Reaction	Renatured (Commentary)	Source Tissue	Specific Activity [micromol/min/mg]	Storage Stability	Substrates and Products (Substrate)	Subunits	Temperature Optimum [°C]	Temperature Range [°C]	Temperature Stability [°C]	Turnover Number [1/s]	pH Optimum	pH Range	pH Stability	Cofactor	Ki Value [mM]	pI Value	IC50 Value	Activating Compound (protein specific)	Application (protein specific)	Cloned(Commentary) (protein specific)	Cofactor (protein specific)	Crystallization (Commentary) (protein specific)	Engineering (protein specific)	General Stability (protein specific)	IC50 Value (protein specific)	Inhibitors (protein specific)	Ki Value [mM] (protein specific)	KM Value [mM] (protein specific)	Localization (protein specific)	Metals/Ions (protein specific)	Molecular Weight [Da] (protein specific)	Natural Substrates/ Products (Substrates) (protein specific)	Organic Solvent Stability (protein specific)	Oxidation Stability (protein specific)	Posttranslational Modification (protein specific)	Purification (Commentary) (protein specific)	Renatured (Commentary) (protein specific)	Source Tissue (protein specific)	Specific Activity [micromol/min/mg] (protein specific)	Storage Stability (protein specific)	Substrates and Products (Substrate) (protein specific)	Subunits (protein specific)	Temperature Optimum [°C] (protein specific)	Temperature Range [°C] (protein specific)	Temperature Stability [°C] (protein specific)	Turnover Number [1/s] (protein specific)	pH Optimum (protein specific)	pH Range (protein specific)	pH Stability (protein specific)	pI Value (protein specific)	Expression	General Information	General Information (protein specific)	Expression (protein specific)	KCat/KM [mM/s]	KCat/KM [mM/s] (protein specific)
714636	To-Figueras		Hepatoerythropoietic porphyria ...	Homo sapiens	Br. J. Dermatol.	165	499-505	2011	-	-	1	-	2	-	-	-	-	-	-	-	-	4	-	-	1	-	-	1	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	-	2	-	-	-	-	-	-	-	-	-	-	1	1	-	-	-
715739	Bushnell		The first branching point in p ...	Homo sapiens	J. Comput. Chem.	32	822-834	2011	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
716915	Ito		Uroporphyrinogen decarboxylase ...	Homo sapiens	Sci. Transl. Med.	3	67ra7	2011	-	1	-	-	-	-	-	-	-	-	-	-	-	4	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	1	2	2	1	-	-
706767	Ryali		Bullous skin lesions in a pati ...	Homo sapiens	Semin. Dial.	23	83-87	2010	-	1	-	-	-	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
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684418	Wang		Direct assay of enzymes in hem ...	Homo sapiens	Anal. Chem.	80	2599-2605	2008	-	-	-	-	-	-	-	-	1	-	-	-	-	3	-	-	-	-	-	1	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
691372	Saito		Interaction of the molecular c ...	Synechococcus elongatus	Biosci. Biotechnol. Biochem.	72	1394-1397	2008	-	-	1	-	-	-	1	-	-	-	1	-	-	5	-	-	1	-	-	-	-	-	1	1	-	-	1	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	-	1	-	-	-	-	1	-	-	-	-	1	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-
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692689	Nagaraj		Localisation of Plasmodium fal ...	Homo sapiens, Plasmodium falciparum	Int. J. Parasitol.	39	559-568	2008	2	-	1	-	4	1	1	3	2	-	2	-	-	6	-	-	2	-	-	1	-	1	4	2	1	-	-	-	1	-	-	-	-	1	-	2	-	1	-	-	4	1	-	1	-	3	2	-	2	-	-	-	-	2	-	1	-	1	4	2	1	-	-	-	1	-	-	1	-	-	-	-	-	-
694882	Lewis		Uroporphyrinogen decarboxylati ...	Homo sapiens	Proc. Natl. Acad. Sci. USA	105	17328-17333	2008	-	-	-	-	-	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
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680488	Fan		Crystal structure of uroporphy ...	Bacillus subtilis	J. Bacteriol.	189	3573-3580	2007	-	-	1	1	-	-	-	-	-	-	3	-	-	4	-	-	1	-	-	-	-	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	-	-	-	-	-	-	-	3	-	-	-	-	1	-	-	-	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
682571	Phillips		A porphomethene inhibitor of u ...	Homo sapiens, Mus musculus	Proc. Natl. Acad. Sci. USA	104	5079-5084	2007	-	-	-	-	-	-	2	-	2	-	-	-	-	6	-	-	-	-	-	4	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	2	-	-	-	-	-	-	-	-	4	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
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650890	Chaufan		Comparison between crab hepato ...	Neohelice granulata, Rattus norvegicus	Comp. Biochem. Physiol. B	133	251-256	2002	-	2	-	-	-	-	-	2	-	-	1	2	-	7	-	-	2	-	-	2	-	-	6	-	2	2	-	-	2	2	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	2	-	-	1	2	-	-	-	2	-	2	-	-	6	-	2	2	-	-	2	2	-	-	-	-	-	-	-	-
649149	Martins		Tobacco uroporphyrinogen-III d ...	Nicotiana tabacum	Acta Crystallogr. Sect. D	57	1709-1711	2001	-	-	1	1	-	-	-	-	4	-	1	1	-	3	-	-	1	-	-	-	-	-	2	1	-	-	-	-	-	-	-	-	-	1	-	-	-	1	-	1	-	-	-	-	-	-	4	-	1	1	-	-	-	1	-	-	-	-	2	1	-	-	-	-	-	-	-	1	-	-	-	-	-	-
650726	Phillips		Functional consequences of nat ...	Homo sapiens	Blood	98	3179-3185	2001	-	1	1	1	-	-	-	-	-	-	-	1	-	2	-	-	1	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	1	1	1	1	-	-	-	-	-	-	-	-	-	1	-	-	-	1	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
651526	Chaufan		How does hexachlorobenzene tre ...	Rattus norvegicus	Int. J. Biochem. Cell Biol.	33	621-630	2001	-	-	-	-	-	-	7	-	-	1	1	1	-	3	-	-	1	-	-	1	-	-	1	-	-	1	-	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	7	-	-	-	1	1	1	-	-	-	1	-	1	-	-	1	-	-	1	-	-	1	1	-	-	-	-	-	-	-	-
652198	Martins		Crystal structure and substrat ...	Nicotiana tabacum	J. Biol. Chem.	276	44108-44116	2001	-	-	-	1	-	-	-	-	-	-	-	1	-	5	-	-	1	-	-	-	-	-	2	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	1	-	-	-	1	-	-	-	-	2	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
390946	Mock		Expression of uroporphyrinogen ...	Nicotiana tabacum	J. Biol. Chem.	274	4231-4238	1999	-	-	1	-	-	-	-	-	-	-	-	1	-	1	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
649782	Billi de Catabbi		Porphyria-induced hepatic porp ...	Rattus norvegicus	Biochem. Mol. Biol. Int.	47	945-956	1999	-	-	-	-	-	1	2	-	-	-	-	1	-	3	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	2	-	-	-	-	-	1	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
651454	Christiansen		Screening for mutations in the ...	Homo sapiens	Hum. Mutat.	14	222-232	1999	-	1	1	-	6	-	-	-	-	-	-	1	-	2	-	-	-	-	-	-	-	-	2	-	-	-	1	-	-	-	-	-	-	-	-	-	1	1	-	-	6	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	2	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-
4442	Laterriere	-	Expression, purification, crys ...	Homo sapiens	Acta Crystallogr. Sect. D	54	476-478	1998	-	-	1	1	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4440	Roberts		Purification and properties of ...	Homo sapiens	Methods Enzymol.	281	349-355	1997	1	-	-	-	-	-	9	4	1	-	1	1	-	2	1	-	1	-	-	2	1	-	5	1	-	-	-	-	3	-	-	-	-	-	-	1	-	-	-	-	-	-	-	9	-	4	1	-	1	1	-	1	-	1	-	2	1	-	5	1	-	-	-	-	3	-	-	-	-	-	-	-	-	-
4447	Mylchreest		Studies on the mechanism of ur ...	Rattus norvegicus	Toxicol. Appl. Pharmacol.	145	23-33	1997	-	-	-	-	-	-	-	-	-	-	-	1	-	2	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4451	Phillips		Characterization and crystalli ...	Homo sapiens	Protein Sci.	6	1343-1346	1997	-	-	1	1	-	-	-	-	1	-	-	1	-	4	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4439	Mock		Isolation, sequencing and expr ...	Hordeum vulgare, Nicotiana tabacum	Plant Mol. Biol.	28	245-256	1995	-	-	2	-	-	-	-	-	-	-	-	-	-	7	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4450	Elder		Uroporphyrinogen decarboxylase ...	Homo sapiens	J. Bioenerg. Biomembr.	27	207-214	1995	-	-	-	-	-	-	-	-	-	-	1	1	-	4	-	-	-	-	-	-	-	-	2	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	1	-	-	-	-	-	-	-	-	2	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4445	Jones		Purification and properties of ...	Rhodobacter sphaeroides	Biochem. J.	293	703-712	1993	1	-	-	-	-	1	17	2	-	1	1	-	-	3	-	-	1	-	-	-	1	1	2	1	-	-	1	-	2	1	1	-	-	-	-	1	-	-	-	-	-	1	-	17	-	2	-	1	1	-	-	-	-	1	-	-	1	1	2	1	-	-	1	-	2	1	1	-	-	-	-	-	-	-
4441	Green-Thompson		Inhibition of chick embryo hep ...	Gallus gallus	Can. J. Physiol. Pharmacol.	70	939-942	1992	-	-	-	-	-	-	1	-	-	-	-	-	-	2	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4449	Mukerji		Uroporphyrinogen decarboxylase ...	Homo sapiens	Int. J. Biochem.	24	105-119	1992	-	-	-	-	-	-	-	4	-	-	2	-	-	2	-	-	1	-	-	2	1	1	2	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	4	-	-	2	-	-	-	-	1	-	2	1	1	2	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4448	Afonso		Further evidence on the photod ...	Homo sapiens	J. Enzyme Inhib.	5	225-233	1991	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4443	Felix		Purification and properties of ...	Saccharomyces cerevisiae	Eur. J. Biochem.	188	393-403	1990	-	-	-	-	-	-	6	3	-	-	1	-	-	3	-	-	1	-	-	-	1	1	-	1	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	6	-	3	-	-	1	-	-	-	-	1	-	-	1	1	-	1	-	-	-	-	1	-	-	-	-	-	-	-	-	-
4446	Lambrecht		Inhibition of uroporphyrinogen ...	Mus musculus	Biochem. J.	269	437-441	1990	-	-	-	-	-	-	1	-	-	-	-	-	-	4	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4444	Juknat		Studies on uroporphyrinogen de ...	Euglena gracilis	Eur. J. Biochem.	179	423-428	1989	1	-	-	-	-	-	-	2	-	-	1	-	-	3	-	-	1	-	-	1	-	1	2	-	-	-	2	-	2	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	2	-	-	1	-	-	-	-	1	-	1	-	1	2	-	-	-	2	-	2	-	-	-	-	-	-	-	-	-
4436	Francis		Oxidation of uroporphyrinogens ...	Mus musculus	FEBS Lett.	233	311-314	1988	-	-	-	-	-	-	1	-	-	-	-	-	-	3	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4437	Romana		Rat uroporphyrinogen decarboxy ...	Rattus norvegicus	Nucleic Acids Res.	15	7211	1987	-	-	1	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4438	Mukerji		Evidence for two uroporphyrino ...	Homo sapiens	Biochem. Biophys. Res. Commun.	146	1196-1203	1987	-	-	-	-	-	-	-	2	-	-	-	1	-	2	-	-	1	-	-	2	-	-	5	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	1	-	-	-	1	-	2	-	-	5	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4433	Mukerji		In vitro studies of the mechan ...	Rattus norvegicus	Arch. Biochem. Biophys.	224	619-629	1986	-	-	-	-	-	-	4	5	-	-	-	-	-	4	-	-	-	-	-	2	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	4	-	5	-	-	-	-	-	-	-	-	-	2	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4434	Seki		Uroporphyrinogen decarboxylase ...	Gallus gallus	Methods Enzymol.	123	415-421	1986	-	-	-	-	-	-	13	-	-	1	1	-	-	2	-	-	1	-	-	2	2	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	13	-	-	-	1	1	-	-	-	-	1	-	2	2	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4435	Koopmann	-	Porphyrin biosynthesis in Rhod ...	Rhodopseudomonas palustris	Int. J. Biochem.	18	935-944	1986	-	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	1	-	-	-	1	1	1	-	-	-	1	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	1	-	-	1	1	1	-	-	-	1	1	1	-	-	-	-	-	-	-	-	-
4432	Mukerji		Reduced substrate affinity for ...	Homo sapiens	Biochem. Biophys. Res. Commun.	127	517-525	1985	-	-	-	-	-	-	-	6	-	-	-	1	-	3	-	-	-	-	-	2	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	6	-	-	-	1	-	-	-	-	-	2	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4429	Francis		Assay of mouse liver uroporphy ...	Mus musculus	Anal. Biochem.	138	404-410	1984	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4430	Elder	-	Human uroporphyrinogen decarbo ...	Homo sapiens	Biochem. Soc. Trans.	12	663-664	1984	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	2	-	-	1	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	1	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-
4431	Sinclair		Inhibition of uroporphyrinogen ...	Gallus gallus	Biochem. J.	222	737-748	1984	-	-	-	-	-	-	3	-	-	-	-	-	-	2	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4425	De Verneuil		Purification and properties of ...	Homo sapiens	J. Biol. Chem.	258	2454-2460	1983	-	-	-	-	-	-	10	4	-	-	1	-	-	2	-	-	1	-	-	2	1	-	5	1	-	-	-	-	3	4	-	-	-	-	-	-	-	-	-	-	-	-	-	10	-	4	-	-	1	-	-	-	-	1	-	2	1	-	5	1	-	-	-	-	3	4	-	-	-	-	-	-	-	-
4426	Kawanishi		Uroporphyrinogen decarboxylase ...	Gallus gallus	J. Biol. Chem.	258	4285-4292	1983	-	-	-	-	-	-	17	-	-	-	1	-	-	3	-	-	-	-	-	2	1	-	2	1	-	-	-	-	1	1	-	1	-	-	-	-	-	-	1	-	-	-	-	17	-	-	-	-	1	-	-	-	-	-	-	2	1	-	2	1	-	-	-	-	1	1	-	-	-	-	-	-	-	-
4427	Straka		Purification and characterizat ...	Bos taurus	Biochemistry	22	4664-4672	1983	-	-	-	-	-	-	9	5	-	-	-	-	-	3	-	-	1	-	-	2	1	-	8	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	9	-	5	-	-	-	-	-	-	-	1	-	2	1	-	8	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4428	Elder		Purification of uroporphyrinog ...	Homo sapiens	Biochem. J.	215	45-55	1983	-	-	-	-	-	-	1	-	-	-	1	-	-	2	-	-	1	-	-	3	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	1	-	-	-	-	1	-	3	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4424	Smith		Investigations of rat liver ur ...	Rattus norvegicus	Biochem. J.	195	241-250	1981	-	-	-	-	-	-	1	-	-	-	-	-	-	2	-	-	-	-	-	2	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	2	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4420	De Verneuil		Some kinetic properties of hum ...	Homo sapiens	Biochim. Biophys. Acta	611	174-186	1980	-	-	-	-	-	-	4	6	-	-	-	-	-	3	-	-	-	-	-	1	-	-	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	4	-	6	-	-	-	-	-	-	-	-	-	1	-	-	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4423	Kardish	-	Measurement of heme biosynthet ...	Rattus norvegicus	J. Appl. Biochem.	2	159-167	1980	-	-	-	-	-	-	1	-	-	-	-	1	-	1	-	-	-	-	-	5	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	-	-	5	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4421	Barnard		Stereochemical and mechanistic ...	Gallus gallus	J. Chem. Soc. Perkin Trans. I	1979	2354-2363	1979	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	-	-	1	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4422	Smith		Decarboxylation of porphyrinog ...	Rattus norvegicus	Biochem. J.	183	455-458	1979	-	-	-	-	-	-	-	1	-	-	-	-	-	3	-	-	-	-	-	3	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	3	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4419	Garcia		Porphyrin biosynthesis. X-Porp ...	Gallus gallus	Biochim. Biophys. Acta	309	203-210	1973	-	-	-	-	-	-	-	2	-	-	-	-	-	1	-	-	-	-	-	1	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	1	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
4418	Tomio		Porphyrin biosynthesis. VII. P ...	Gallus gallus	Biochim. Biophys. Acta	198	353-363	1970	2	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	1	1	-	2	-	-	-	1	-	1	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	1	-	2	-	-	-	1	-	1	-	-	-	-	-	-	-	-	-
4417	Mauzerall		Porphyrin biosynthesis in eryt ...	Oryctolagus cuniculus	J. Biol. Chem.	232	1141-1162	1958	-	-	-	-	-	-	6	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	2	-	-	-	-	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	6	-	-	-	-	-	-	-	-	-	-	-	1	-	-	2	-	-	-	-	-	1	1	-	-	-	-	-	-	-	-