Uroporphyrinogen decarboxylation as a benchmark for the catalytic proficiency of enzymes

Lewis, C.A.; Wolfenden, R.; Proc. Natl. Acad. Sci. USA 105, 17328-17333 (2008)

 show all sequences of 4.1.1.37

Data extracted from this reference:

Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Homo sapiens P06132
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-
Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
Uroporphyrinogen III
-
 694882 Homo sapiens Coproporphyrinogen III + CO2
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-
-
 ?
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
Uroporphyrinogen III
-
 694882 Homo sapiens Coproporphyrinogen III + CO2
-
-
-
 ?

See also following references to EC number 4.1.1.37 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
714636To-FiguerasHepatoerythropoietic porphyria ...Homo sapiensBr. J. Dermatol.165499-5052011--1-2--------5--1--1--2--------------1--2------------1-1--2----------11---
715739BushnellThe first branching point in p ...Homo sapiensJ. Comput. Chem.32822-8342011-------------3--------11----------------------------------11--------------
716915ItoUroporphyrinogen decarboxylase ...Homo sapiensSci. Transl. Med.367ra72011-1-----------4-----1----------------1------------------1------------1221--
706767RyaliBullous skin lesions in a pati ...Homo sapiensSemin. Dial.2383-872010-1-----------5----------------------1-------------------------------------
691975CribierPorphyria cutanea tarda, hepat ...Homo sapiensDermatology21815-212009-1-----------5-----2--1-------------1------------------2--1---------------
701665BergoniaReduction of porphyrins to por ...Homo sapiensAnal. Biochem.38474-782009-----------1-1--------2--------------------------1--------2---------------
703118WarbyStructural and kinetic charact ...Homo sapiensCell. Mol. Biol. (Noisy-le-grand)5540-452009--113--6---1-4--1--31-2----6---------1-13----6---1---1-31-2----6----------
703269AarsandFamilial and sporadic porphyri ...Homo sapiensClin. Chem.55795-8032009-1-----------3-----2----------------1------------------2------------------
703279BadenasIdentification and characteriz ...Homo sapiensClin. Genet.75346-3532009--1-9-----11-4--1--21-3--------------1--9-------11---1-21-3---------------
705145PhillipsSubstrate shuttling between ac ...Homo sapiensJ. Mol. Biol.389306-3142009--113-----31-2--1-----21-------------1-13-------31---1----21--------------
684418WangDirect assay of enzymes in hem ...Homo sapiensAnal. Chem.802599-26052008--------1----4-----1--4-----------------------1--------1--4---------------
691372SaitoInteraction of the molecular c ...Synechococcus elongatusBiosci. Biotechnol. Biochem.721394-13972008--2---2---1--5--2-----12--2----------2-----2----1----2----12--2-----------
691874RemenyikChildhood-onset mild cutaneous ...Homo sapiensClin. Exp. Dermatol.33602-6052008----1--------4-----1--1-----------------1--------------1--1---------------
692689NagarajLocalisation of Plasmodium fal ...Homo sapiens, Plasmodium falciparumInt. J. Parasitol.39559-568200816-1-48139-2--6--2--1-8428---1----1-16-1--48-1-39-2----2-1-8428---1--1------
694882LewisUroporphyrinogen decarboxylati ...Homo sapiensProc. Natl. Acad. Sci. USA10517328-173332008-------------4--------1-----------------------------------1---------------
679005JuarezStudies on uroporphyrinogen de ...Parachlorella kessleriCan. J. Microbiol.53303-3122007-------1--2--4--11---311--2-1----------------1--2----1---311--2-1---------
680488FanCrystal structure of uroporphy ...Bacillus subtilisJ. Bacteriol.1893573-35802007--11------3--4--1-----11-------------1-1--------3----1----11--------------
682571PhillipsA porphomethene inhibitor of u ...Homo sapiens, Mus musculusProc. Natl. Acad. Sci. USA1045079-50842007------2-2----7-----5--2--------------------2--2--------5--2---------------
682774CunhaHuman uroporphyrinogen III syn ...Homo sapiensProteins71855-8732007--1-------1--4--1---2-1------1-------1----------1----1--2-1------1--------
663631NezamzadehIdentification of a mutation i ...Ovis ariesAnim. Genet.36297-3022005-------------8------------------------------------------------------------
665446ChaufanAbnormal kinetic behavior of u ...Rattus norvegicusJ. Biochem. Mol. Toxicol.1919-242005-----------1-4--1--1--2--------------------------1---1-1--2---------------
666917ChristiansenExpression and characterizatio ...Homo sapiensScand. J. Clin. Lab. Invest.65227-2352005--1-4--4-----4--1-----1--------------1--4----4-------1----1---------------
654975JonesAn effective chromatographic s ...Gallus gallusBioorg. Med. Chem. Lett.145559-55642004-----------1-3--1--3--1--------------------------1---1-3--1---------------
664858Poblete-GutierrezThe molecular basis of porphyr ...Homo sapiensExp. Dermatol.13372-3792004-----------1-3--------1--------------------------1--------1---------------
650999PhillipsStructural basis for tetrapyrr ...Homo sapiensEMBO J.226225-62332003--114------1-1--1-----2--------------1-14--------1---1----2---------------
650797TavazziLevels of uroporphyrinogen dec ...Homo sapiensCell. Mol. Biol.4827-322002-1---------1-4-----2--2-------------1------------1-----2--2---------------
650890ChaufanComparison between crab hepato ...Neohelice granulata, Rattus norvegicus, Rattus norvegicus WistarComp. Biochem. Physiol. B133251-2562002-2-----2--12-8--2--2--6-242--22------2--------2--12---2-2--6-242--22--------
649149MartinsTobacco uroporphyrinogen-III d ...Nicotiana tabacumActa Crystallogr. Sect. D571709-17112001--19----4-91-3--1-----21---------1---1-9------4-91---1----21-------1------
650726PhillipsFunctional consequences of nat ...Homo sapiensBlood983179-31852001-111-------1-3--1-----1--------1----1111---------1---1----1---------------
651526ChaufanHow does hexachlorobenzene tre ...Rattus norvegicusInt. J. Biochem. Cell Biol.33621-6302001------7--111-4--1--2--1--1--11-------------7---111---1-2--1--1--11--------
652198MartinsCrystal structure and substrat ...Nicotiana tabacumJ. Biol. Chem.27644108-441162001---9-------1-5--1-----21---------------9---------1---1----21--------------
390946MockExpression of uroporphyrinogen ...Nicotiana tabacumJ. Biol. Chem.2744231-42381999--1--------1-1--------2--------------1-----------1--------2---------------
649782Billi de CatabbiPorphyria-induced hepatic porp ...Rattus norvegicusBiochem. Mol. Biol. Int.47945-9561999-----12----1-3--------2------------------1-2-----1--------2---------------
651454ChristiansenScreening for mutations in the ...Homo sapiensHum. Mutat.14222-2321999-11-6------1-3--------2---1---------11--6--------1--------2---1-----------
4442Laterriere-Expression, purification, crys ...Homo sapiensActa Crystallogr. Sect. D54476-4781998--11---------1--1--------------------1-1-------------1--------------------
4440RobertsPurification and properties of ...Homo sapiensMethods Enzymol.281349-35519971-----941-11-29-1--21-51----3------1-------9-41-11-9-1-21-51----3---------
4447MylchreestStudies on the mechanism of ur ...Rattus norvegicusToxicol. Appl. Pharmacol.14523-331997-----------1-3--------1--------------------------1--------1---------------
4451PhillipsCharacterization and crystalli ...Homo sapiensProtein Sci.61343-13461997--11----1--1-4--------1--------------1-1------1--1--------1---------------
4439MockIsolation, sequencing and expr ...Hordeum vulgare, Nicotiana tabacumPlant Mol. Biol.28245-2561995--4----------7-----------------------4------------------------------------
4450ElderUroporphyrinogen decarboxylase ...Homo sapiensJ. Bioenerg. Biomembr.27207-2141995----------11-5--------21------------------------11--------21--------------
4445JonesPurification and properties of ...Rhodobacter sphaeroidesBiochem. J.293703-712199316----169232-1616--3--16---16163216--16-211----16-----16-92-32-1616----16--16163216--16-211-------
4441Green-ThompsonInhibition of chick embryo hep ...Gallus gallusCan. J. Physiol. Pharmacol.70939-9421992------1------2-----1-----------------------1-----------1------------------
4449MukerjiUroporphyrinogen decarboxylase ...Homo sapiensInt. J. Biochem.24105-1191992-------4--2--2--1--21121---------------------4--2----1-21121--------------
4448AfonsoFurther evidence on the photod ...Homo sapiensJ. Enzyme Inhib.5225-2331991------1------1-----1-----------------------1-----------1------------------
4443FelixPurification and properties of ...Saccharomyces cerevisiaeEur. J. Biochem.188393-4031990------63--1--3--1---11-1----1--------------6-3--1----1--11-1----1---------
4446LambrechtInhibition of uroporphyrinogen ...Mus musculusBiochem. J.269437-4411990------1------4-----1-----------------------1-----------1------------------
4444JuknatStudies on uroporphyrinogen de ...Euglena gracilis, Euglena gracilis ZEur. J. Biochem.179423-42819896------2--6--3--6--1-62---12-2------6---------2--6----6-1-62---12-2---------
4436FrancisOxidation of uroporphyrinogens ...Mus musculusFEBS Lett.233311-3141988------1------3-----1-----------------------1-----------1------------------
4437RomanaRat uroporphyrinogen decarboxy ...Rattus norvegicusNucleic Acids Res.1572111987--1----------3-----------------------1------------------------------------
4438MukerjiEvidence for two uroporphyrino ...Homo sapiensBiochem. Biophys. Res. Commun.1461196-12031987-------2---1-2--1--2--51---------------------2---1---1-2--51--------------
4433MukerjiIn vitro studies of the mechan ...Rattus norvegicusArch. Biochem. Biophys.224619-6291986------45-----5-----2--5--------------------4-5---------2--5---------------
4434SekiUroporphyrinogen decarboxylase ...Gallus gallusMethods Enzymol.123415-4211986------13--11--2--1--22-1--------------------13---11----1-22-1---------------
4435Koopmann-Porphyrin biosynthesis in Rhod ...Rhodopseudomonas palustrisInt. J. Biochem.18935-9441986----------11--1--11---111111---11111-------------------11----11--111111---11111---------
4432MukerjiReduced substrate affinity for ...Homo sapiensBiochem. Biophys. Res. Commun.127517-5251985-------6---1-4-----3--3----------------------6---1-----3--3---------------
4429FrancisAssay of mouse liver uroporphy ...Mus musculusAnal. Biochem.138404-4101984-------------3-----3-----------------------------------3------------------
4430Elder-Human uroporphyrinogen decarbo ...Homo sapiensBiochem. Soc. Trans.12663-6641984-------------1-----2--1---1----------------------------2--1---1-----------
4431SinclairInhibition of uroporphyrinogen ...Gallus gallusBiochem. J.222737-7481984------3------2-----1-----------------------3-----------1------------------
4425De VerneuilPurification and properties of ...Homo sapiensJ. Biol. Chem.2582454-24601983------104--1--2--1--21-51----34-------------10-4--1----1-21-51----34--------
4426KawanishiUroporphyrinogen decarboxylase ...Gallus gallusJ. Biol. Chem.2584285-42921983------17---1--3-----21-21----11-8------8----17----1------21-21----11--------
4427StrakaPurification and characterizat ...Bos taurusBiochemistry224664-46721983------95-----3--1--21-8--------------------9-5-------1-21-8---------------
4428ElderPurification of uroporphyrinog ...Homo sapiensBiochem. J.21545-551983------1---1--2--1--31--1-------------------1----1----1-31--1--------------
4424SmithInvestigations of rat liver ur ...Rattus norvegicusBiochem. J.195241-2501981------1------2-----2--5--------------------1-----------2--5---------------
4420De VerneuilSome kinetic properties of hum ...Homo sapiensBiochim. Biophys. Acta611174-1861980------46-----4-----1--6--------------------4-6---------1--6---------------
4423Kardish-Measurement of heme biosynthet ...Rattus norvegicusJ. Appl. Biochem.2159-1671980------1----1-1-----5--3--------------------1-----1-----5--3---------------
4421BarnardStereochemical and mechanistic ...Gallus gallusJ. Chem. Soc. Perkin Trans. I19792354-23631979-----------1-1---1-1--1--------------------------1-----1--1---------------
4422SmithDecarboxylation of porphyrinog ...Rattus norvegicusBiochem. J.183455-4581979-------1-----3-----3--5----------------------1---------3--5---------------
4419GarciaPorphyrin biosynthesis. X-Porp ...Gallus gallusBiochim. Biophys. Acta309203-2101973-------2-----1-----1--3----------------------2---------1--3---------------
4418TomioPorphyrin biosynthesis. VII. P ...Gallus gallusBiochim. Biophys. Acta198353-36319709------------1--1--11-2---8-1------9-----------------1-11-2---8-1---------
4417MauzerallPorphyrin biosynthesis in eryt ...Oryctolagus cuniculusJ. Biol. Chem.2321141-11621958------6------1-----1--2-----11-------------6-----------1--2-----11--------