Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1 -P2 variation

Foltmann, B.; Drohse, H.B.; Nielsen, P.K.; James, M.N.G.; Biochim. Biophys. Acta 1121, 75-82 (1992)

 show all sequences of 3.4.23.3

Data extracted from this reference:

Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Sus scrofa
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-
-
Posttranslational Modification
Posttranslational Modification Commentary Organism
proteolytic modification zymogen: progastricsin Sus scrofa
Posttranslational Modification (protein specific)
Posttranslational Modification Commentary Organism
proteolytic modification zymogen: progastricsin Sus scrofa

See also following references to EC number 3.4.23.3 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
718005HassanProgastriscin: Structure, func ...Homo sapiensJ. Mol. Cell Biol.2118-1272010-1-----------4-----10---1------------1------------------10---1--------2112--
709708FiluszovaPeptide inhibitor modified mag ...Homo sapiens, Rattus norvegicusJ. Sep. Sci.322017-20212009-------------6------------------------------------------------------------
686228FengCharacterization and expressio ...Epinephelus coioidesComp. Biochem. Physiol. B Biochem. Mol. Biol.149275-2842008--1----------4-----7-------------1---1-----------------7-----------1------
684879TerovaRegulation of progastricsin mR ...Dicentrarchus labraxBiochem. Biophys. Res. Commun.363591-5962007--1--------1-2-----1--1--------------1-----------1-----1--1---------------
667343SchreiberGastric antibacterial efficien ...Homo sapiensArch. Microbiol.184335-3402006-----11----1-4-1---2--1-----1------------1-1-----1--1--2--1-----1---------
668809Tang-Gastricsin ...Homo sapiens, Macaca fuscata, Sus scrofa, Xenopus laevisHandbook of Proteolytic Enzymes (Barrett, J.; Rawlings, N.D.; Woessner, J.F., eds.)138-432004--21--1-4----4-442-16--22-------------2-1---1--4-----44-16--22--------------
652641AthaudaInhibition of human pepsin and ...Homo sapiensJ. Enzyme Inhib. Med. Chem.18219-2242003------1------3-----1--2--------------------1-----------1--2---------------
36860SuzukiPrimary structure of human pep ...Capra hircusComp. Biochem. Physiol. B122453-4601999------1------1-11-----11----1--------------1--------11----11----1---------
36846NaritaHuman prostatic gastric sinoge ...Suncus murinusJ. Biochem.1211010-10171997------1---1--1-21--11-2-----12-------------1----1---21-11-2-----12--------
35006JonesThe amino terminal sequences o ...Homo sapiensAspartic Proteinases: Structure, Function, Biology and Biomedical Implications (Takahashi, K., ed.), Plenum Press, New York83-891995----------1--3-1--------------------------------1---1---------------------
35012JamesPepsinogens and pepsins from h ...Homo sapiensAspartic Proteinases: Structure, Function, Biology and Biomedical Implications (Takahashi, K., ed.), Plenum Press, New York11-181995---1---------3-----1-------------------1---------------1------------------
36864SzecsiPepsinogen C and pepsin C from ...Homo sapiensJ. Androl.14351-3581993-----------1-3-----1--1--------------------------1-----1--1---------------
36865RaoSpecificity in the binding of ...Homo sapiensJ. Med. Chem.362614-26201993------3------1-----------------------------3------------------------------
36861SanchezSeparation of porcine pepsinog ...Homo sapiensJ. Biol. Chem.26724725-247311992-1----1----1-3-1---2--2-------------1------1-----1--1--2--2---------------
36863FoltmannSpecificity in the binding of ...Sus scrofaBiochim. Biophys. Acta112175-821992-------------5-1------------------------------------1---------------------
36849CooperSeparation of human pepsin and ...Homo sapiensBiochemistry288596-86031989------2------1-----------------------------2------------------------------
36850IshiharaDesign, synthesis and analysis ...Rattus norvegicusJ. Biol. Chem.26410193-101991989-----------1-4--------1--------------------------1--------1---------------
36868TaggartHuman pepsinogen C (progastric ...Homo sapiensJ. Biol. Chem.264375-3791989--1-----1----3-----2-----------------1--------1--------2------------------
36862HayanoGastricsin-mediated proteolyti ...Homo sapiensJ. Biol. Chem.2631382-13851988--1----------3-----------------------1------------------------------------
36851KucerovaPurification and characterizat ...Homo sapiensJ. Chromatogr.376409-4121986-------------3--1--3---------------------------------1-3------------------
36867IchiharaNucleotide sequence of a nearl ...Rattus norvegicusEur. J. Biochem.1617-121986--1----------1-----1---1-------------1-----------------1---1--------------
36852DunnPepsinogen C and pepsin C. Fur ...Sus scrofaBiochem. Soc. Trans.131041-10431985-------1-----1--------1----1-----------------1------------1----1----------
36847ReidX-ray studies of aspartic prot ...Homo sapiensCell Tissue Res.236597-6001984------21-----3-1---2--1--------------------2-1------1--2--1---------------
36853MartinBiochemical and immunological ...Bos taurusEur. J. Biochem.12231-391982------2---1--2--1-----3--------------------2----1----1----3---------------
36848ChiangPrimary structure and transcri ...Homo sapiensArch. Biochem. Biophys.21014-201981------1------1-11--1--1-----1--------------1--------11-1--1-----1---------
36855MutoBiochemical and immunological ...Rattus norvegicusJ. Biochem.87717-7231980-------------7-1---1--------------------------------1--1------------------
36856RyleThe specificity of some pig an ...Homo sapiens, Sus scrofaBiochem. J.179247-2491979-------6-----4--------8----6-----------------6------------8----6----------
36857AuffretThe catalytic activity of pig ...Sus scrofaBiochem. J.179239-2461979------18-----2--------8----81--------------1-8------------8----81---------
36866KageyamaPepsinogen C and pepsin C from ...Macaca fuscataJ. Biochem.80983-9921976------3---1--2-2---2--2-----11-------------3----1---2--2--2-----11--------
36845SepulvedaIdentification of the acid pro ...Homo sapiensBiochem. Biophys. Res. Commun.631106-11121975----------1--2----------------------------------1-------------------------
36859Ryle-Isolation and characterization ...Sus scrofaBiochem. J.11041968-------------1-----1--3--------------------------------1--3---------------
36854RylePepsinogen C and pepsin C. Fur ...Sus scrofaBiochem. J.101176-1831966----------1--1-11-------------------------------1---11--------------------
36858Richmond-Purification and characterizat ...Homo sapiensBiochim. Biophys. Acta29453-4541958-------------1-----1--1-----11-------------------------1--1-----11--------