Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone

Sanchez, V.C.; Goldstein, J.; Stuart, R.C.; Hovanesian, V.; Huo, L.; Munzberg, H.; Friedman, T.C.; Bjorbaek, C.; Nillni, E.A.; J. Clin. Invest. 114, 357-369 (2004)

 show all sequences of 3.4.21.94

Data extracted from this reference:

Activating Compound
Activating Compound Commentary Organism Structure
additional information leptin stimulates the PC1 expression via STAT3 acting on the PC2 promoter Rattus norvegicus
-
Cloned(Commentary)
Commentary Organism
expression of PC2 in human 293T cells, leptin has a stimulatory effect on the PC2 promoter, which is enhanced by co-expression of STAT3, overview Rattus norvegicus
Inhibitors
Inhibitors Commentary Organism Structure
additional information starvation reduces the serum levels of leptin which decreases PC1 expression, the effect can be reversed by administration of exogenous leptin Rattus norvegicus
-
Natural Substrates/ Products (Substrates)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
prothyrotropin-releasing hormone + H2O Rattus norvegicus processing and activation of the inactive prohormone is required for regulation of energy balance via leptin, enzyme regulation, overview thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
-
-
 ?
Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Rattus norvegicus
-
 male sprague-dawley rats
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Source Tissue
Source Tissue Commentary Organism Textmining
hypothalamus
-
 Rattus norvegicus
-
neuron hypothalamic Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
prothyrotropin-releasing hormone + H2O processing and activation of the inactive prohormone is required for regulation of energy balance via leptin, enzyme regulation, overview 669626 Rattus norvegicus thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
-
-
-
 ?
prothyrotropin-releasing hormone + H2O processing of the prohormone 669626 Rattus norvegicus thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
-
-
-
 ?
Activating Compound (protein specific)
Activating Compound Commentary Organism Structure
additional information leptin stimulates the PC1 expression via STAT3 acting on the PC2 promoter Rattus norvegicus
-
Cloned(Commentary) (protein specific)
Commentary Organism
expression of PC2 in human 293T cells, leptin has a stimulatory effect on the PC2 promoter, which is enhanced by co-expression of STAT3, overview Rattus norvegicus
Inhibitors (protein specific)
Inhibitors Commentary Organism Structure
additional information starvation reduces the serum levels of leptin which decreases PC1 expression, the effect can be reversed by administration of exogenous leptin Rattus norvegicus
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
prothyrotropin-releasing hormone + H2O Rattus norvegicus processing and activation of the inactive prohormone is required for regulation of energy balance via leptin, enzyme regulation, overview thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
-
-
 ?
Source Tissue (protein specific)
Source Tissue Commentary Organism Textmining
hypothalamus
-
 Rattus norvegicus
-
neuron hypothalamic Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
prothyrotropin-releasing hormone + H2O processing and activation of the inactive prohormone is required for regulation of energy balance via leptin, enzyme regulation, overview 669626 Rattus norvegicus thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
-
-
-
 ?
prothyrotropin-releasing hormone + H2O processing of the prohormone 669626 Rattus norvegicus thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
-
-
-
 ?

See also following references to EC number 3.4.21.94 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
717856HelwigDynamic modulation of PC2-medi ...Mus musculusJ. Biol. Chem.28642504-4251320111----------1-1--------1------------1-------------1--------1----------11---
709603ZhangNeuropeptidomic analysis estab ...Mus musculusJ. Neurochem.1121168-11792010--1----------2-----7-----------------1-----------------7-------------11---
717906IinoPossible relevance between pro ...Homo sapiensJ. Clin. Endocrinol. Metab.954003-40112010-------------1-----1-----------------------------------1-------------11---
700298KowalskaSynthetic small-molecule proho ...Mus musculusMol. Pharmacol.75617-6252009--1---8------1--------1-1---1---7----1-----87-------------1-1---1---------
708778CumminsExpression of prohormone conve ...Haliotis asininaInt. J. Dev. Biol.531081-10882009--1----------4-----4-----------------1-----------------4-------------11---
709250ZhanDefective neuropeptide process ...Rattus norvegicusJ. Cereb. Blood Flow Metab.29698-7062009------1--1---3-----5--211---1--------------1---1-------5--211---1---1221--
710101TangPro-protein convertase-2/carbo ...Rattus norvegicusNeurosci. Bull.257-142009------1------1-1---1-----------------------1--------1--1------------1111--
682808Portela-GomesProhormone convertases 1/3, 2, ...Homo sapiensRegul. Pept.146117-1242008--------1----1-----1--1-----------------------1--------1--1---------------
700473EspinosaDifferential regulation of pro ...Rattus norvegicusNeuroscience156788-7992008-1-----------1-----1----------------1------------------1------------------
677957LeeProcessing and trafficking of ...Mus musculusBiochem. Biophys. Res. Commun.355825-8292007--1-1-1------1--1-----1--------------1--1--1---------1----1---------------
683932BillovaImmunohistochemical expression ...Rattus norvegicusNeuroscience147403-4182007-1------1----1-----5--11------------1---------1--------5--11--------------
686303WidemanA switch from prohormone conve ...Mus musculusDiabetes562744-27522007-11----------1-----1--1-------------11-----------------1--1---------------
689018LeakAssociation of the proprotein ...Homo sapiensMol. Genet. Metab.92145-1502007-1-----------2----------------------1-------------------------------------
689214MarandiProprotein convertases 1 and 2 ...Rattus norvegicusNeurosci. Lett.420198-2032007-------------1-----1-----------------------------------1------------------
669436UgleholdtProhormone convertase 1/3 is e ...Mus musculusJ. Biol. Chem.28111050-110572006----1------1-1-----2--1-----------------1--------1-----2--1---------------
686302MarzbanImpaired NH2-terminal processi ...Mus musculusDiabetes552192-22012006-11-1--------1--------1-------------11--1-----------------1---------------
688466KitabgiProhormone convertases differe ...Homo sapiens, Mus musculus, Rattus norvegicusJ. Mol. Med.84628-6342006--1-1-1------3-----11--3--------------1--1--1-----------11--3---------------
688525PanThe role of prohormone convert ...Mus musculusJ. Neurochem.981763-17772006----1--------2-----1--1-----------------1--------------1--1---------------
688526HussonDefective processing of neurop ...Caenorhabditis elegansJ. Neurochem.981999-20122006----1--------5--------1-----------------1-----------------1---------------
689212CroissandeauIncreased stress-induced analg ...Mus musculusNeurosci. Lett.40671-752006----1--------1--------------------------1---------------------------------
668083TzimasAbnormal expression and proces ...Homo sapiensBMC Cancer51492005-----------1-1-----3--1--------------------------1-----3--1---------------
668422DeySignificance of prohormone con ...Mus musculusEndocrinology146713-7272005--1----------1--------3--------------1--------------------3---------------
669378KacprzakMutations of the PC2 substrate ...Mus musculusJ. Biol. Chem.28031850-318582005--1-10-11-1---1--1-----2-1---21--1----1--10--111-1-----1----2-1---21--------
670480TagenRecombinant prohormone convert ...Mus musculusPeptides262530-25352005-----------1-1--------3--------------------------1--------3---------------
668377MarzbanRole of beta-cell prohormone c ...Mus musculusDiabetes53141-1482004--1--------1-1-----1--1--------------1-----------1-----1--1---------------
668720OgiwaraExpression of proprotein conve ...Oryzias latipesGene33779-892004--1----------5-1-1-6---1-------------1--------------1--6---1--------------
669626SanchezRegulation of hypothalamic pro ...Rattus norvegicusJ. Clin. Invest.114357-36920041-1---1----1-1-----2--2------------1-1-----1-----1-----2--2---------------
669843Henrich-Proprotein convertase models b ...Homo sapiensJ. Mol. Biol.345211-2272004-------------1---1-----1-----------------------------------1--------------
651008CornwallThe cystatin-related epididyma ...Mus musculusEndocrinology144901-9082003------1------1--------1---------1----------11-------------1---------------
653858LiProhormone convertase 2 enzyma ...Homo sapiens, Mus musculus, Rattus norvegicusRegul. Pept.110197-2052003---------1---3--------1-----11-----------------1----------1-----11--------
651994ApletalinaMutations in the catalytic dom ...Mus musculusJ. Biol. Chem.27514667-1467720001-1---1---21-1--1-----1-----11-----1-1-----1----21---1----1-----11--------
651892JohanningSpecificity of prohormone conv ...Mus musculusJ. Biol. Chem.27322672-226801998--1----8---1-1--1-----15----8---------1-------8---1---1----15----8----------
651913DayProdynorphin processing by pro ...Mus musculus, Rattus norvegicusJ. Biol. Chem.273829-8361998--1----4-----3--1---1-5---1----------1-------4-------1--1-5---1-----------
29874SeidahPro-protein convertases of sub ...Homo sapiensMethods Enzymol.244175-1881994--1--------1-1-----1--7--------------1-----------1-----1--7---------------
29875RouilleProglucagon is processed to gl ...MammaliaProc. Natl. Acad. Sci. USA913242-32461994-----------2-1-----1--3--------------------------2-----1--3---------------
29417SteinerThe new enzymology of precurso ...Homo sapiensJ. Biol. Chem.26723435-234381992--1----------1-----1--1-----1--------1-----------------1--1-----1---------
29877SmeekensIdentification of a human insu ...Homo sapiensJ. Biol. Chem.2652997-30001990-------------1-----1-----------------------------------1------------------