High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients

Weeks, J.L.; Zoraghi, R.; Beasley, A.; Sekhar, K.R.; Francis, S.H.; Corbin, J.D.; Int. J. Imp. Res. 17, 5-9 (2005)

Data extracted from this reference:

Cloned(Commentary)

Commentary	Organism
baculovirus expression system, PDE11A4	Homo sapiens

Inhibitors

Inhibitors	Commentary	Organism	Structure
cAMP	IC50: 1200 nM, PDE11A4	Homo sapiens
cGMP	IC50: 560 nM, PDE11A4	Homo sapiens
dipyridamole	IC50: 840 nM, PDE11A4	Homo sapiens
sildenafil	IC50: 3800 nM, 1000fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication	Homo sapiens
tadalafil	IC50: 73 nM, 40fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication	Homo sapiens
vardenafil	IC50: 840 nM, 9300fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Commentary	Organism	Structure
0.00097	-	3',5'-cGMP	30°C, pH 7.5, PDE11A4	Homo sapiens
0.0024	-	3',5'-cAMP	30°C, pH 7.5, PDE11A4	Homo sapiens

Organism

Organism	Primary Accession No. (UniProt)	Commentary	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Commentary Substrates	Literature (Substrates)	Organism	Products	Commentary (Products)	Literature (Products)	Organism (Products)	Reversibility
3',5'-cAMP + H2O	maximal velocity for cAMP is 4fold to 10fold higher than for cGMP, PDE11A4	668990	Homo sapiens	5'-AMP	-	-	-	?
3',5'-cGMP + H2O	maximal velocity for cAMP is 4fold to 10fold higher than for cGMP, PDE11A4	668990	Homo sapiens	5'-GMP	-	-	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Commentary	Organism	Inhibitor	Structure
7.3e-05	-	IC50: 73 nM, 40fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication	Homo sapiens	tadalafil
0.00056	-	IC50: 560 nM, PDE11A4	Homo sapiens	cGMP
0.00084	-	IC50: 840 nM, PDE11A4	Homo sapiens	dipyridamole
0.00084	-	IC50: 840 nM, 9300fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication	Homo sapiens	vardenafil
0.0012	-	IC50: 1200 nM, PDE11A4	Homo sapiens	cAMP
0.0038	-	IC50: 3800 nM, 1000fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication	Homo sapiens	sildenafil

Cloned(Commentary) (protein specific)

Commentary	Organism
baculovirus expression system, PDE11A4	Homo sapiens

IC50 Value (protein specific)

IC50 Value	IC50 Value Maximum	Commentary	Organism	Inhibitor	Structure
7.3e-05	-	IC50: 73 nM, 40fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication	Homo sapiens	tadalafil
0.00056	-	IC50: 560 nM, PDE11A4	Homo sapiens	cGMP
0.00084	-	IC50: 840 nM, PDE11A4	Homo sapiens	dipyridamole
0.00084	-	IC50: 840 nM, 9300fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication	Homo sapiens	vardenafil
0.0012	-	IC50: 1200 nM, PDE11A4	Homo sapiens	cAMP
0.0038	-	IC50: 3800 nM, 1000fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication	Homo sapiens	sildenafil

Inhibitors (protein specific)

Inhibitors	Commentary	Organism	Structure
cAMP	IC50: 1200 nM, PDE11A4	Homo sapiens
cGMP	IC50: 560 nM, PDE11A4	Homo sapiens
dipyridamole	IC50: 840 nM, PDE11A4	Homo sapiens
sildenafil	IC50: 3800 nM, 1000fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication	Homo sapiens
tadalafil	IC50: 73 nM, 40fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication	Homo sapiens
vardenafil	IC50: 840 nM, 9300fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication	Homo sapiens

KM Value [mM] (protein specific)

KM Value [mM]	KM Value Maximum [mM]	Substrate	Commentary	Organism	Structure
0.00097	-	3',5'-cGMP	30°C, pH 7.5, PDE11A4	Homo sapiens
0.0024	-	3',5'-cAMP	30°C, pH 7.5, PDE11A4	Homo sapiens

Substrates and Products (Substrate) (protein specific)

Substrates	Commentary Substrates	Literature (Substrates)	Organism	Products	Commentary (Products)	Literature (Products)	Organism (Products)	Reversibility
3',5'-cAMP + H2O	maximal velocity for cAMP is 4fold to 10fold higher than for cGMP, PDE11A4	668990	Homo sapiens	5'-AMP	-	-	-	?
3',5'-cGMP + H2O	maximal velocity for cAMP is 4fold to 10fold higher than for cGMP, PDE11A4	668990	Homo sapiens	5'-GMP	-	-	-	?

See also following references to EC number 3.1.4.17 (sorted by year of publication):

No.	1st author	Pub Med	title	organims	journal	volume	pages	year	Activating Compound	Application	Cloned(Commentary)	Crystallization (Commentary)	Engineering	General Stability	Inhibitors	KM Value [mM]	Localization	Metals/Ions	Molecular Weight [Da]	Natural Substrates/ Products (Substrates)	Organic Solvent Stability	Organism	Oxidation Stability	Posttranslational Modification	Purification (Commentary)	Reaction	Renatured (Commentary)	Source Tissue	Specific Activity [micromol/min/mg]	Storage Stability	Substrates and Products (Substrate)	Subunits	Temperature Optimum [°C]	Temperature Range [°C]	Temperature Stability [°C]	Turnover Number [1/s]	pH Optimum	pH Range	pH Stability	Cofactor	Ki Value [mM]	pI Value	IC50 Value	Activating Compound (protein specific)	Application (protein specific)	Cloned(Commentary) (protein specific)	Cofactor (protein specific)	Crystallization (Commentary) (protein specific)	Engineering (protein specific)	General Stability (protein specific)	IC50 Value (protein specific)	Inhibitors (protein specific)	Ki Value [mM] (protein specific)	KM Value [mM] (protein specific)	Localization (protein specific)	Metals/Ions (protein specific)	Molecular Weight [Da] (protein specific)	Natural Substrates/ Products (Substrates) (protein specific)	Organic Solvent Stability (protein specific)	Oxidation Stability (protein specific)	Posttranslational Modification (protein specific)	Purification (Commentary) (protein specific)	Renatured (Commentary) (protein specific)	Source Tissue (protein specific)	Specific Activity [micromol/min/mg] (protein specific)	Storage Stability (protein specific)	Substrates and Products (Substrate) (protein specific)	Subunits (protein specific)	Temperature Optimum [°C] (protein specific)	Temperature Range [°C] (protein specific)	Temperature Stability [°C] (protein specific)	Turnover Number [1/s] (protein specific)	pH Optimum (protein specific)	pH Range (protein specific)	pH Stability (protein specific)	pI Value (protein specific)	Expression	General Information	General Information (protein specific)	Expression (protein specific)	KCat/KM [mM/s]	KCat/KM [mM/s] (protein specific)
715153	Giachini		Decreased cGMP level contribut ...	Rattus norvegicus	Hypertension	57	655-663	2011	-	-	-	-	-	-	-	-	-	1	-	-	-	3	-	-	-	-	-	3	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	3	-	-	1	-	-	-	-	-	-	-	-	-	1	3	3	1	-	-
715378	Kimura		Enzymatic and mutational analy ...	Myxococcus xanthus	J. Bacteriol.	193	2053-2057	2011	-	-	1	-	1	-	3	2	-	3	-	-	-	1	-	-	-	-	-	-	2	-	3	1	1	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	1	-	-	3	-	2	-	3	-	-	-	-	-	-	-	-	2	-	3	1	1	-	-	-	1	-	-	-	-	1	1	-	-	-
711813	Keravis		Cyclic nucleotide phosphodiest ...	Homo sapiens	Curr. Pharm. Des.	16	1114-1125	2010	-	-	-	-	-	-	1	-	1	-	-	1	-	2	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	1	-	-	1	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
713000	Huang		Identification of novel cyclic ...	Cavia porcellus	Mol. Biotechnol.	44	66-70	2010	-	-	-	-	-	-	1	-	-	-	-	2	-	9	-	-	-	-	-	2	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	6	-	-	-	-	-	12	-	-	-	-	-	7	-	-	12	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
716015	Lu		Characterization of the struct ...	Homo sapiens	J. Phys. Chem. B	114	7022-7028	2010	-	-	-	-	-	-	-	-	-	2	-	1	-	2	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	1	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
716163	Penmatsa		Compartmentalized cyclic adeno ...	Homo sapiens, Sus scrofa	Mol. Biol. Cell	21	1097-1110	2010	-	-	1	-	-	-	4	-	2	-	-	2	-	5	-	-	-	-	-	4	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	4	-	-	2	-	-	2	-	-	-	-	-	4	-	-	2	-	-	-	-	-	-	-	-	-	-	2	2	-	-	-
716347	Lakics		Quantitative comparison of pho ...	Homo sapiens	Neuropharmacology	59	367-374	2010	-	-	-	-	-	-	-	-	-	-	-	-	-	11	-	-	-	-	-	17	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	130	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
716435	Adderley		Regulation of cAMP by phosphod ...	Homo sapiens	Pharmacol. Rep.	62	475-482	2010	1	-	-	-	-	-	2	-	2	-	-	-	-	1	-	1	-	-	-	3	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	2	-	-	2	-	-	-	-	-	1	-	-	3	-	-	3	-	-	-	-	-	-	-	-	-	1	2	2	1	-	-
692369	Kimura		Enzymatic characteristics of t ...	Myxococcus xanthus	FEBS Lett.	583	443-448	2009	-	-	1	-	-	-	9	8	-	2	2	-	-	1	-	-	1	-	-	-	-	-	10	-	2	1	-	8	1	1	-	-	-	-	-	-	-	1	-	-	-	-	-	9	-	8	-	2	2	-	-	-	-	1	-	-	-	-	10	-	2	1	-	8	1	1	-	-	-	-	-	-	-	-
693825	Threlfell		Inhibition of phosphodiesteras ...	Rattus norvegicus	J. Pharmacol. Exp. Ther.	328	785-795	2009	-	1	-	-	-	-	2	-	-	-	-	-	-	3	-	-	-	-	-	3	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	3	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
703570	Goncalves		The flavonoid dioclein is a se ...	Bos taurus, Homo sapiens	Eur. J. Pharmacol.	620	78-83	2009	-	-	-	-	-	-	6	-	-	-	-	2	-	4	-	-	2	-	-	4	-	-	6	-	-	-	-	-	-	-	-	2	2	-	8	-	-	-	2	-	-	-	8	6	2	-	-	-	-	2	-	-	-	2	-	4	-	-	6	-	-	-	-	-	-	-	-	-	-	1	1	-	-	-
691199	Hung		A new nonhydrolyzable reactive ...	Homo sapiens	Bioorg. Chem.	36	141-147	2008	-	-	1	-	1	-	3	-	-	-	-	-	-	3	-	-	1	-	-	2	-	-	3	-	-	-	-	-	-	-	-	-	1	-	-	-	-	1	-	-	1	-	-	3	1	-	-	-	-	-	-	-	-	1	-	2	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
691712	Herget		Real-time monitoring of phosph ...	Homo sapiens	Cell. Signal.	20	1423-1431	2008	-	-	1	-	-	-	4	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	3	-	-	1	-	-	-	-	3	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
691887	Siuciak		The role of phosphodiesterases ...	Homo sapiens, Rattus norvegicus	CNS Drugs	22	983-993	2008	-	-	-	-	-	-	9	-	-	-	-	-	-	3	-	-	-	-	-	2	-	-	4	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	1	9	-	-	-	-	-	-	-	-	-	-	-	2	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
692191	Santos-Silva		PDE4 and PDE5 regulate cyclic ...	Homo sapiens	Eur. J. Pharmacol.	582	102-109	2008	1	-	-	-	-	-	2	-	-	1	-	-	-	4	-	-	-	-	-	1	-	-	2	-	-	-	-	-	-	-	-	1	-	-	-	1	-	-	2	-	-	-	-	5	-	-	-	2	-	-	-	-	-	-	-	3	-	-	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
692197	van Donkelaar		Phosphodiesterase 2 and 5 inhi ...	Rattus norvegicus	Eur. J. Pharmacol.	600	98-104	2008	-	1	-	-	-	-	1	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
692697	Chan		Inhibitory effects of querceti ...	Cavia porcellus	Invest. New Drugs	26	417-424	2008	-	-	-	-	-	-	11	-	-	-	-	-	-	1	-	-	1	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	9	-	-	-	-	-	-	-	9	11	-	-	-	-	-	-	-	-	-	1	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
693820	Schmidt		Preclinical characterization o ...	Rattus norvegicus	J. Pharmacol. Exp. Ther.	325	681-690	2008	-	1	-	-	-	-	1	-	-	-	-	1	-	2	-	-	-	-	-	1	-	-	3	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	-	-	-	-	1	1	-	-	-	-	-	1	-	-	-	-	-	1	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
694373	Dlaboga		Chronic haloperidol and clozap ...	Rattus norvegicus	Neuropharmacology	54	745-754	2008	3	-	1	-	-	-	-	-	2	-	2	-	-	3	-	-	-	-	-	2	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	3	-	1	-	-	-	-	-	-	-	-	2	-	2	-	-	-	-	-	-	2	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
678053	Bader		Seven Dictyostelium discoideum ...	Dictyostelium discoideum	Biochem. J.	402	153-161	2007	-	-	-	-	-	-	-	4	-	-	-	-	-	1	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
678221	Weeks		N-terminal domain of phosphodi ...	Homo sapiens	Biochemistry	46	10353-10364	2007	-	-	-	-	1	-	2	7	-	-	4	-	-	5	-	-	-	-	-	-	-	-	3	1	-	-	-	-	-	-	-	-	-	-	8	-	-	-	-	-	1	-	8	2	-	7	-	-	4	-	-	-	-	-	-	-	-	-	3	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
678445	Witwicka		Expression and activity of cGM ...	Rattus norvegicus	Biochim. Biophys. Acta	1773	209-218	2007	1	-	-	-	-	-	-	-	2	-	-	-	-	3	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
679247	Surapisitchat		Differential regulation of end ...	Homo sapiens	Circ. Res.	101	811-818	2007	1	1	-	-	-	-	1	-	-	-	-	1	-	2	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	1	1	1	-	-	-	-	-	1	1	-	-	-	-	-	1	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
679666	Rutten		Time-dependent involvement of ...	Rattus norvegicus	Eur. J. Pharmacol.	558	107-112	2007	-	1	-	-	-	-	3	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
679784	Dunkern		Characterization of inhibitors ...	Homo sapiens	FEBS J.	274	4812-4824	2007	-	-	-	-	-	-	5	2	-	-	-	-	-	3	-	-	-	-	-	1	-	-	2	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	5	-	2	-	-	-	-	-	-	-	-	-	1	-	-	2	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
681407	Shenoy		Structural and biochemical ana ...	Mycobacterium tuberculosis	J. Mol. Biol.	365	211-225	2007	-	-	-	1	2	-	-	-	-	2	-	-	-	3	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	2	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
681526	Hepp		Phosphodiesterase type 2 and t ...	Mus musculus	J. Neurochem.	102	1875-1886	2007	-	-	-	-	-	-	2	-	-	-	-	1	-	2	-	-	-	-	-	3	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	1	-	-	-	-	-	3	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
682912	Brown		The effect of oxidative stress ...	Homo sapiens, Mus musculus	Toxicol. Lett.	168	1-6	2007	-	2	-	-	-	-	2	-	-	-	-	-	-	2	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
667433	Dolci		Subcellular localization and r ...	Homo sapiens	Biochem. Biophys. Res. Commun.	341	837-846	2006	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
667909	Sairenji		Ca(2+)/calmodulin-dependent cy ...	Oryctolagus cuniculus	Biomed. Res.	27	37-44	2006	-	-	-	-	-	-	1	1	-	1	-	1	-	3	-	-	1	-	-	3	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	1	-	1	-	-	-	1	-	3	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
668230	Nilsson		Plasma membrane cyclic nucleot ...	Rattus norvegicus	Cell. Signal.	18	1713-1721	2006	-	-	-	-	-	-	-	-	3	-	-	1	-	5	-	-	-	-	-	3	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	1	-	-	-	-	-	3	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
670147	Sharma		Assay and purification of calm ...	Bos taurus	Methods Mol. Biol.	312	325-342	2006	-	1	-	-	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	1	2	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	2	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
670983	Oelke		Expression of cAMP and cGMP-ph ...	Homo sapiens	Urology	67	1111-1116	2006	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
678545	Suzuki		Effects of 1-benzylxanthines o ...	Cavia porcellus	Biol. Pharm. Bull.	29	131-134	2006	-	-	-	-	-	-	11	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	11	-	-	-	-	-	-	-	11	11	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
679248	Nagel		Role of nuclear Ca2+/calmoduli ...	Rattus norvegicus	Circ. Res.	98	777-784	2006	-	-	-	-	1	-	-	-	2	-	-	1	-	2	-	-	-	-	-	2	-	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	2	-	-	1	-	-	-	-	-	2	-	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
679676	Uckert		Immunohistochemical distributi ...	Homo sapiens	Eur. Urol.	49	740-745	2006	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
680475	Kimura		Contribution of the cyclic nuc ...	Myxococcus xanthus	J. Bacteriol.	188	823-828	2006	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
680689	Gross-Langenhoff		cAMP is a ligand for the tande ...	Homo sapiens	J. Biol. Chem.	281	2841-2846	2006	-	-	-	-	1	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
681045	de Vente		The role of phosphodiesterase ...	Rattus norvegicus	J. Chem. Neuroanat.	31	275-303	2006	-	-	-	-	-	-	-	-	-	-	-	1	-	3	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
681548	Santone		Gene expression and protein lo ...	Rattus norvegicus	J. Neurosci. Res.	84	1020-1026	2006	2	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	2	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
682531	Bender		PDE1B2 regulates cGMP and a su ...	Homo sapiens	Proc. Natl. Acad. Sci. USA	103	460-465	2006	-	-	-	-	1	-	-	-	-	1	-	1	-	1	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	1	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
667501	Day		Cyclic nucleotide phosphodiest ...	Drosophila melanogaster	Biochem. J.	388	333-342	2005	-	-	1	-	-	-	2	4	-	-	-	-	-	5	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	-	4	-	-	1	-	-	-	-	4	2	-	4	-	-	-	-	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
667641	Shenoy		The Rv0805 gene from Mycobacte ...	Mycobacterium tuberculosis	Biochemistry	44	15695-15704	2005	-	-	1	1	7	-	1	1	-	1	-	1	-	7	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	7	-	-	1	-	1	-	1	-	1	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
667684	Iffland		Structural determinants for in ...	Homo sapiens	Biochemistry	44	8312-8325	2005	-	-	1	1	16	-	2	2	-	-	-	-	-	4	-	-	1	-	-	-	-	-	2	-	-	-	-	2	-	-	-	-	-	-	2	-	-	1	-	1	16	-	2	2	-	2	-	-	-	-	-	-	-	1	-	-	-	-	2	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-
667904	Vasta		Identification of a new varian ...	Mus musculus	Biol. Reprod.	73	598-609	2005	-	-	1	-	-	-	-	-	-	-	-	1	-	3	-	-	-	-	-	2	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	2	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
668213	Ahlstrom		Cyclic nucleotide phosphodiest ...	Homo sapiens	Cell. Mol. Biol. Lett.	10	305-319	2005	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
668560	Kunz		A FYVE-containing unusual cycl ...	Trypanosoma cruzi	FEBS J.	272	6412-6422	2005	-	-	1	-	-	-	5	2	1	4	-	-	-	5	-	-	-	-	-	-	-	-	2	1	-	-	-	-	-	-	-	-	-	1	5	-	-	1	-	-	-	-	5	5	-	2	1	4	-	-	-	-	-	-	-	-	-	-	2	1	-	-	-	-	-	-	-	1	-	-	-	-	-	-
668968	Michikawa		Phosphodiesterases 1 and 2 reg ...	Oryctolagus cuniculus	Int. J. Biochem. Cell Biol.	37	876-886	2005	-	-	-	-	-	-	-	-	-	-	-	1	-	3	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
668988	Loughney		3',5'-cyclic nucleotide phosph ...	Homo sapiens	Int. J. Imp. Res.	17	320-325	2005	-	-	-	-	-	-	1	-	-	-	-	-	-	3	-	-	-	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
668989	Pomara	-	Inhibition of phosphodiesteras ...	Homo sapiens	Int. J. Imp. Res.	17	385-386	2005	-	1	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
668990	Weeks	-	High biochemical selectivity o ...	Homo sapiens	Int. J. Imp. Res.	17	5-9	2005	-	-	1	-	-	-	6	2	-	-	-	-	-	1	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	6	-	-	1	-	-	-	-	6	6	-	2	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
669329	Nikolaev		Real-time monitoring of the PD ...	Bos taurus	J. Biol. Chem.	280	1716-1719	2005	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
669403	Hambleton		Isoforms of cyclic nucleotide ...	Homo sapiens	J. Biol. Chem.	280	39168-39174	2005	-	-	-	-	-	-	2	3	-	-	-	1	-	2	-	-	-	-	-	2	-	-	2	-	-	-	-	3	-	-	-	-	6	-	-	-	-	-	-	-	-	-	-	2	6	3	-	-	-	1	-	-	-	-	-	2	-	-	2	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-
669701	D'Andrea		Expression of PDE11A in normal ...	Homo sapiens	J. Histochem. Cytochem.	53	895-903	2005	-	-	-	-	-	-	4	-	-	-	-	1	-	3	-	-	-	-	-	6	-	-	1	-	-	-	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	4	4	-	-	-	-	-	1	-	-	-	-	-	6	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
670145	Keravis		Assessment of phosphodiesteras ...	Rattus norvegicus	Methods Mol. Biol.	307	63-74	2005	-	1	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
670146	Yan		Determination of Ca2+/calmodul ...	Rattus norvegicus	Methods Mol. Biol.	307	85-92	2005	-	1	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	1	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	1	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
670448	Das		Potential role of calmodulin-d ...	Homo sapiens	Oncol. Rep.	14	1059-1063	2005	-	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	-	-	-	11	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	11	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
671011	Waldkirch		Cyclic AMP-specific and cyclic ...	Homo sapiens	World J. Urol.	23	405-410	2005	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
667545	Ko		Inhibitory effects of flavonoi ...	Cavia porcellus	Biochem. Pharmacol.	68	2087-2094	2004	-	-	-	-	-	-	10	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	22	-	-	-	-	-	-	-	22	10	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
667546	Guerra de Gonzalez		Cyclic nucleotide-dependent ph ...	Bos taurus	Biochem. Pharmacol.	68	651-658	2004	-	-	-	-	-	-	-	-	-	-	-	1	-	2	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
668133	D'Angelo		Prune cAMP phosphodiesterase b ...	Homo sapiens	Cancer Cell	5	137-149	2004	-	-	1	-	1	-	3	2	-	-	-	1	-	3	-	-	1	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	3	-	-	1	-	-	1	-	3	3	-	2	-	-	-	1	-	-	-	1	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
668987	Bischoff	-	Potency, selectivity, and cons ...	Homo sapiens	Int. J. Imp. Res.	16	S11-S14	2004	-	-	-	-	-	-	4	-	-	-	-	-	-	1	-	-	-	-	-	11	-	-	6	-	-	-	-	-	-	-	-	-	-	-	7	-	-	-	-	-	-	-	7	4	-	-	-	-	-	-	-	-	-	-	-	11	-	-	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
670387	Bender		Specific localized expression ...	Mus musculus	Neurochem. Int.	45	853-857	2004	-	-	-	-	-	-	-	-	-	-	-	1	-	2	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
651468	Sharma		Diversity of calcium action in ...	Bos taurus, Mammalia	Ind. J. Biochem. Biophys.	40	77-91	2003	2	-	-	-	-	-	6	8	2	2	2	2	-	2	-	2	2	-	-	2	1	-	4	3	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	6	-	8	2	2	2	2	-	-	2	2	-	2	1	-	4	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-
649520	Tanaka		Changes in phosphodiesterase a ...	Rattus norvegicus	Arch. Oral Biol.	47	567-576	2002	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
652763	O'Grady		Cyclic AMP-dependent Cl secret ...	Homo sapiens	J. Membr. Biol.	185	137-144	2002	-	-	-	-	-	-	6	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	15	-	-	-	-	-	-	-	15	6	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
653848	Richter		3',5'-Cyclic nucleotide phosph ...	Escherichia coli	Proteins Struct. Funct. Genet.	46	278-286	2002	1	-	-	-	-	-	-	-	-	2	-	-	-	1	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
649519	Murata		Expression of phosphodiesteras ...	Rattus norvegicus	Arch. Oral Biol.	46	453-457	2001	-	-	-	-	-	-	1	-	1	-	-	-	-	3	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
650504	Yan		Stage and cell-specific expres ...	Mus musculus	Biol. Reprod.	64	1746-1754	2001	-	-	-	-	-	-	-	-	1	-	-	-	-	3	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
651105	Yuasa		Identification of rat cyclic n ...	Rattus norvegicus	Eur. J. Biochem.	268	4440-4448	2001	-	-	-	-	-	-	8	2	-	-	-	-	-	4	-	-	-	-	-	1	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	8	-	2	-	-	-	-	-	-	-	-	-	1	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
649518	Murata		Expression of phosphodiesteras ...	Rattus norvegicus	Arch. Oral Biol.	45	1043-1047	2000	-	-	-	-	-	-	-	-	1	-	-	-	-	2	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
649785	Sudo		Potent effects of novel anti-p ...	Bos taurus	Biochem. Pharmacol.	59	347-356	2000	-	-	1	-	-	-	10	6	-	-	-	-	-	2	-	-	-	-	-	-	-	-	7	-	-	-	-	-	-	-	-	-	3	-	24	-	-	1	-	-	-	-	24	10	3	6	-	-	-	-	-	-	-	-	-	-	-	-	7	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
653640	Hetman		Cloning and characterization o ...	Homo sapiens	Proc. Natl. Acad. Sci. USA	97	12891-12895	2000	-	-	-	-	-	-	2	4	-	-	-	-	-	3	-	-	-	-	-	-	-	-	2	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	4	-	-	-	-	-	-	-	-	-	-	-	-	2	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
654017	Lim	-	Purification and characterizat ...	Sinorhizobium fredii	World J. Microbiol. Biotechnol.	16	19-22	2000	-	-	-	-	-	-	11	1	-	1	1	-	-	2	-	-	1	-	-	-	-	-	2	1	1	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	11	-	1	-	1	1	-	-	-	-	1	-	-	-	-	2	1	1	-	-	-	1	-	-	-	-	-	-	-	-	-
135264	Lugnier		Characterization of cyclic nuc ...	Ovis aries	Biochim. Biophys. Acta	1472	431-446	1999	-	-	-	-	-	-	-	-	1	-	-	-	-	2	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135271	Kotera		Characterization and phosphory ...	Homo sapiens	Biochem. Biophys. Res. Commun.	261	551-557	1999	-	-	1	-	-	-	-	1	-	-	-	-	-	1	-	-	-	-	-	6	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	6	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135279	Fujishige		Striatum- and testis-specific ...	Rattus norvegicus	Eur. J. Biochem.	266	1118-1127	1999	-	-	1	-	-	-	1	1	1	1	-	-	-	4	-	-	1	-	-	2	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	1	1	1	-	-	-	-	-	1	-	2	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135268	Yu		Identification and characteriz ...	Homo sapiens	Cell. Signal.	9	519-529	1997	-	-	1	-	-	-	6	-	-	1	-	-	-	6	-	-	-	-	-	1	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	6	-	-	-	1	-	-	-	-	-	-	-	1	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135273	Leroy		Characterization of two recomb ...	Homo sapiens, Rattus norvegicus	Biochemistry	35	10194-10202	1996	-	-	2	-	-	-	2	-	-	-	-	-	-	6	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135274	Clapham	-	Purification and kinetic prope ...	Canis lupus familiaris	Biochem. Soc. Trans.	24	320-321	1996	-	-	-	-	-	-	3	-	-	1	1	-	-	1	-	-	1	-	-	1	-	-	3	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	1	1	-	-	-	-	1	-	1	-	-	3	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135265	Yan		Molecular cloning and characte ...	Rattus norvegicus	Proc. Natl. Acad. Sci. USA	92	9677-9681	1995	-	-	-	-	-	-	-	1	-	1	-	-	-	3	-	-	-	-	-	1	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	-	-	-	-	-	-	1	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135266	Sharma		Characterization of calmodulin ...	Bos taurus	Biochem. J.	299	97-100	1994	-	-	-	-	-	-	-	-	-	1	-	-	-	3	-	-	1	-	-	3	-	-	3	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	3	-	-	3	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135276	Mukai		Separation and characterizatio ...	Rattus norvegicus	Br. J. Pharmacol.	111	389-390	1994	-	-	-	-	-	-	4	1	1	-	-	-	-	3	-	-	-	-	-	2	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	4	-	1	1	-	-	-	-	-	-	-	-	2	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135278	Giorgi		Characterization of 3':5' cycl ...	Mus musculus	FEBS Lett.	324	76-80	1993	-	-	-	-	-	-	1	2	-	-	-	-	-	3	-	-	-	-	-	4	-	-	2	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	1	1	2	-	-	-	-	-	-	-	-	-	4	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135213	Lim	-	Purification and characterisat ...	Sinorhizobium fredii	Biochim. Biophys. Acta	991	353-358	1989	4	-	-	-	-	-	4	2	-	6	1	-	-	1	-	-	1	-	-	-	1	-	3	1	-	-	3	-	1	-	-	-	-	-	-	4	-	-	-	-	-	-	-	4	-	2	-	6	1	-	-	-	-	1	-	-	1	-	3	1	-	-	3	-	1	-	-	-	-	-	-	-	-	-
135272	Lim	-	Identification and characteriz ...	Sinorhizobium fredii	Int. J. Biochem.	21	909-912	1989	1	-	-	-	-	-	6	1	-	-	1	-	-	1	-	-	1	-	-	-	-	-	1	-	-	-	1	-	1	-	-	-	-	-	-	1	-	-	-	-	-	-	-	6	-	1	-	-	1	-	-	-	-	1	-	-	-	-	1	-	-	-	1	-	1	-	-	-	-	-	-	-	-	-
135214	Ulloa		Cyclic nucleotide phosphodiest ...	Neurospora crassa	FEBS Lett.	241	219-222	1988	-	-	-	-	-	-	1	1	-	1	1	-	-	2	-	-	1	-	-	-	1	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	1	1	-	-	-	-	1	-	-	1	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135233	Purvis		High-affinity, calmodulin-depe ...	Rattus norvegicus	Methods Enzymol.	159	675-685	1988	-	-	-	-	-	-	-	-	1	1	-	-	-	2	-	-	-	-	-	2	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	1	-	-	-	-	-	-	-	2	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135234	Sharma		Isolation of bovine brain calm ...	Bos taurus	Methods Enzymol.	159	582-594	1988	-	-	-	-	-	-	-	1	-	1	1	-	-	2	-	-	1	-	-	2	-	2	3	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	1	-	-	-	-	1	-	2	-	2	3	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135235	Kincaid		Purification and properties of ...	Bos taurus, Mammalia	Methods Enzymol.	159	557-573	1988	-	-	-	-	-	-	-	-	-	4	3	-	-	2	-	-	2	-	-	2	-	-	2	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	4	3	-	-	-	-	2	-	2	-	-	2	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135236	Hansen		Purification of calmodulin-sti ...	Bos taurus, Rattus norvegicus	Methods Enzymol.	159	543-557	1988	-	-	-	-	-	-	-	-	-	2	-	-	-	4	-	-	1	-	-	4	2	1	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	1	-	4	2	1	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135240	Chaudry		Calmodulin-stimulated cyclic n ...	Bos taurus	Arch. Biochem. Biophys.	262	439-444	1988	-	-	-	-	-	-	1	3	3	1	-	-	-	2	-	-	1	-	-	4	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	3	3	1	-	-	-	-	-	1	-	4	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135216	Shaw	-	Heat-stable, calcium-inhibited ...	Neurospora crassa	Phytochemistry	27	1281-1288	1987	1	-	-	-	-	-	1	-	-	-	3	-	-	1	-	-	1	-	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	1	-	-	-	-	3	-	-	-	-	1	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135232	Lim	-	Purification and properties of ...	Sinorhizobium fredii	Arch. Microbiol.	146	142-146	1986	3	-	-	-	-	-	11	2	-	2	2	-	-	1	-	-	1	-	-	-	1	-	4	1	-	-	1	-	1	-	-	-	-	-	-	3	-	-	-	-	-	-	-	11	-	2	-	2	2	-	-	-	-	1	-	-	1	-	4	1	-	-	1	-	1	-	-	-	-	-	-	-	-	-
135217	Ryan		Multiple forms of cyclic nucle ...	Mus musculus	Arch. Biochem. Biophys.	241	403-412	1985	-	-	-	-	-	-	5	4	-	1	-	-	-	2	-	-	1	-	-	4	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	5	-	4	-	1	-	-	-	-	-	1	-	4	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135218	Orellana		Properties of a cyclic nucleot ...	Xenopus laevis	Arch. Biochem. Biophys.	231	345-354	1984	6	-	-	-	-	1	2	2	-	1	2	-	-	3	-	-	1	-	-	3	1	-	3	2	-	-	-	-	-	-	-	-	-	-	-	6	-	-	-	-	-	1	-	2	-	2	-	1	2	-	-	-	-	1	-	3	1	-	3	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135219	Grant		Purification and characterizat ...	Homo sapiens	Biochemistry	23	1801-1807	1984	-	-	-	-	-	-	5	2	-	2	1	-	-	4	-	-	1	-	-	2	-	-	3	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	5	-	2	-	2	1	-	-	-	-	1	-	2	-	-	3	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135225	Yamamoto		Purification and characterizat ...	Bos taurus	J. Biol. Chem.	258	12526-12533	1983	-	-	-	-	-	-	3	3	-	3	2	-	-	2	-	-	1	-	-	1	1	1	3	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	3	-	3	2	-	-	-	-	1	-	1	1	1	3	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-
135230	Shaw		Calcium inhibition of a heat-s ...	Neurospora crassa	FEBS Lett.	152	295-298	1983	2	-	-	-	-	-	7	-	-	1	-	-	-	3	-	-	-	-	-	-	-	-	4	-	-	-	1	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	7	-	-	-	1	-	-	-	-	-	-	-	-	-	-	4	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-
667837	Fischer	-	Cyclic nucleotide phosphodiest ...	Chlamydomonas reinhardtii	Biochim. Biophys. Acta	341	421-420	1974	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135254	Pannbacker		Cyclic nucleotide phosphodiest ...	Bos taurus	Science	175	757-758	1972	-	-	-	-	-	-	5	1	1	1	-	-	-	1	-	-	1	-	-	1	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	5	-	1	1	1	-	-	-	-	-	1	-	1	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
135228	Nair		Purification and properties of ...	Canis lupus familiaris	Biochemistry	5	150-157	1966	2	-	-	-	-	-	3	1	-	3	-	-	-	1	-	-	1	-	-	1	1	-	3	-	-	-	-	-	1	-	-	-	-	-	-	2	-	-	-	-	-	-	-	3	-	1	-	3	-	-	-	-	-	1	-	1	1	-	3	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-