Substrate specificity of retinyl ester hydrolase activity in retinal pigment epithelium

Mata, J.R.; Mata, N.L.; Tsin, A.T.C.; J. Lipid Res. 39, 604-612 (1998)

Data extracted from this reference:

Localization

Localization	Commentary	Organism	GeneOntology No.	Textmining
plasma membrane	-	Bos taurus	5886	-

Organism

Organism	Primary Accession No. (UniProt)	Commentary	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Commentary	Organism	Textmining
retinal pigment epithelium	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Commentary Substrates	Literature (Substrates)	Organism	Products	Commentary (Products)	Literature (Products)	Organism (Products)	Reversibility
11-cis-retinyl palmitate + H2O	-	170657	Bos taurus	11-cis-retinol + palmitate	-	170657	Bos taurus	?
More	the 11-cis-isomer is hydrolyzed at a much higher rate than the other isomers, 9-cis, 13-cis, and all-trans-retinyl palmitate	170657	Bos taurus	?	-	-	-	-
More	all-trans-retinyl palmitate and cholesteryl oleate may be hydrolyzed at the same non-specific catalytic site, it is very likely that 11-cis-retinyl palmitate is hydrolyzed at a discrete catalytic site	170657	Bos taurus	?	-	-	-	-

Localization (protein specific)

Localization	Commentary	Organism	GeneOntology No.	Textmining
plasma membrane	-	Bos taurus	5886	-

Source Tissue (protein specific)

Source Tissue	Commentary	Organism	Textmining
retinal pigment epithelium	-	Bos taurus	-

Substrates and Products (Substrate) (protein specific)

Substrates	Commentary Substrates	Literature (Substrates)	Organism	Products	Commentary (Products)	Literature (Products)	Organism (Products)	Reversibility
11-cis-retinyl palmitate + H2O	-	170657	Bos taurus	11-cis-retinol + palmitate	-	170657	Bos taurus	?
More	the 11-cis-isomer is hydrolyzed at a much higher rate than the other isomers, 9-cis, 13-cis, and all-trans-retinyl palmitate	170657	Bos taurus	?	-	-	-	-
More	all-trans-retinyl palmitate and cholesteryl oleate may be hydrolyzed at the same non-specific catalytic site, it is very likely that 11-cis-retinyl palmitate is hydrolyzed at a discrete catalytic site	170657	Bos taurus	?	-	-	-	-

See also following references to EC number 3.1.1.63 (sorted by year of publication):

No.	1st author	Pub Med	title	organims	journal	volume	pages	year	Activating Compound	Application	Cloned(Commentary)	Crystallization (Commentary)	Engineering	General Stability	Inhibitors	KM Value [mM]	Localization	Metals/Ions	Molecular Weight [Da]	Natural Substrates/ Products (Substrates)	Organic Solvent Stability	Organism	Oxidation Stability	Posttranslational Modification	Purification (Commentary)	Reaction	Renatured (Commentary)	Source Tissue	Specific Activity [micromol/min/mg]	Storage Stability	Substrates and Products (Substrate)	Subunits	Temperature Optimum [°C]	Temperature Range [°C]	Temperature Stability [°C]	Turnover Number [1/s]	pH Optimum	pH Range	pH Stability	Cofactor	Ki Value [mM]	pI Value	IC50 Value	Activating Compound (protein specific)	Application (protein specific)	Cloned(Commentary) (protein specific)	Cofactor (protein specific)	Crystallization (Commentary) (protein specific)	Engineering (protein specific)	General Stability (protein specific)	IC50 Value (protein specific)	Inhibitors (protein specific)	Ki Value [mM] (protein specific)	KM Value [mM] (protein specific)	Localization (protein specific)	Metals/Ions (protein specific)	Molecular Weight [Da] (protein specific)	Natural Substrates/ Products (Substrates) (protein specific)	Organic Solvent Stability (protein specific)	Oxidation Stability (protein specific)	Posttranslational Modification (protein specific)	Purification (Commentary) (protein specific)	Renatured (Commentary) (protein specific)	Source Tissue (protein specific)	Specific Activity [micromol/min/mg] (protein specific)	Storage Stability (protein specific)	Substrates and Products (Substrate) (protein specific)	Subunits (protein specific)	Temperature Optimum [°C] (protein specific)	Temperature Range [°C] (protein specific)	Temperature Stability [°C] (protein specific)	Turnover Number [1/s] (protein specific)	pH Optimum (protein specific)	pH Range (protein specific)	pH Stability (protein specific)	pI Value (protein specific)	Expression	General Information	General Information (protein specific)	Expression (protein specific)	KCat/KM [mM/s]	KCat/KM [mM/s] (protein specific)
170657	Mata		Substrate specificity of retin ...	Bos taurus	J. Lipid Res.	39	604-612	1998	-	-	-	-	-	-	-	-	1	-	-	-	-	1	-	-	-	-	-	1	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
170681	Mata		Distribution of 11-cis LRAT, 1 ...	Bos taurus	Biochim. Biophys. Acta	1394	16-22	1998	-	-	-	-	-	-	-	-	1	-	-	1	-	1	-	-	-	-	-	1	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	-	-	-	1	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
170660	Mata		Comparison of retinyl ester hy ...	Bos taurus	J. Lipid Res.	37	1947-1952	1996	-	-	-	-	-	-	3	-	-	-	-	-	-	1	-	-	-	-	-	2	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	2	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
170654	Bustamante		Retinyl ester hydrolase and th ...	Gallus gallus	Am. J. Physiol.	269	R1346-R1350	1995	-	-	-	-	-	-	-	2	-	-	-	-	-	1	-	-	-	-	-	2	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	2	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
170637	Blaner		Hydrolysis of 11-cis- and all- ...	Homo sapiens	J. Biol. Chem.	262	53-58	1987	1	-	-	-	-	-	1	1	-	-	-	-	-	1	-	-	-	-	-	1	-	1	1	-	-	-	1	-	1	1	-	-	-	-	-	1	-	-	-	-	-	-	-	1	-	1	-	-	-	-	-	-	-	-	-	1	-	1	1	-	-	-	1	-	1	1	-	-	-	-	-	-	-	-
170640	Blaner W.S.; Prystowsky		Rat liver retinyl palmitate hy ...	Bos taurus	Biochim. Biophys. Acta	794	419-427	1984	-	-	-	-	-	-	1	1	1	-	-	-	-	1	-	-	-	-	-	1	-	-	2	-	-	-	-	-	1	-	-	-	1	-	-	-	-	-	-	-	-	-	-	1	1	1	1	-	-	-	-	-	-	-	-	1	-	-	2	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-