Mitochondrial-type iron-sulfur cluster biosynthesis genes (IscS and IscU) in the apicomplexan Cryptosporidium parvum

LaGier, M.J.; Tachezy, J.; Stejskal, F.; Kutisova, K.; Keithly, J.S.; Microbiology 149, 3519-3530 (2003)

 show all sequences of 2.8.1.7

Data extracted from this reference:

Cloned(Commentary)
Commentary Organism
expressed in Saccharomyces cerevisiae Cryptosporidium parvum
Localization
Localization Commentary Organism GeneOntology No. Textmining
mitochondrion enzyme has an N-terminal targeting signal that directs the enzyme to mitochondria when expressed in Saccharomyces cerevisiae Cryptosporidium parvum 5739
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Natural Substrates/ Products (Substrates)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
More Cryptosporidium parvum functions as scaffold for the assembly of [Fe-S] prior to their incorporation into apoproteins ?
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Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Cryptosporidium parvum Q8WQX4
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Source Tissue
Source Tissue Commentary Organism Textmining
sporozoite
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 Cryptosporidium parvum
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Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
More functions as scaffold for the assembly of [Fe-S] prior to their incorporation into apoproteins 645639 Cryptosporidium parvum ?
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Cloned(Commentary) (protein specific)
Commentary Organism
expressed in Saccharomyces cerevisiae Cryptosporidium parvum
Localization (protein specific)
Localization Commentary Organism GeneOntology No. Textmining
mitochondrion enzyme has an N-terminal targeting signal that directs the enzyme to mitochondria when expressed in Saccharomyces cerevisiae Cryptosporidium parvum 5739
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Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
More Cryptosporidium parvum functions as scaffold for the assembly of [Fe-S] prior to their incorporation into apoproteins ?
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Source Tissue (protein specific)
Source Tissue Commentary Organism Textmining
sporozoite
-
 Cryptosporidium parvum
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Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
More functions as scaffold for the assembly of [Fe-S] prior to their incorporation into apoproteins 645639 Cryptosporidium parvum ?
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See also following references to EC number 2.8.1.7 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
703682PoliakFunctions and cellular localiz ...Trypanosoma bruceiFEBS J.277383-3932010--------4----4------6-1-1---1--1------1-------4---------6-1-1---1---------
704679ZhangIscS functions as a primary su ...Escherichia coliJ. Biol. Chem.2852302-23082010-------------1--1-----2--------1------1--------------1----2---------1111--
702269BehshadKinetic analysis of cysteine d ...Synechocystis sp.Biochemistry4812014-120232009--1-1--------3--1-----1--------1-----11-1------------1----1---------------
705872AdinolfiBacterial frataxin CyaY is the ...Escherichia coliNat. Struct. Mol. Biol.16390-3962009------1------1--------11-------1------1----1--------------11--------------
690737MiharaThe iscS gene deficiency affec ...Escherichia coliBiochem. Biophys. Res. Commun.372407-4112008-----------1-2--------1--------------------------1--------1---------------
690744WuRegulation of Escherichia coli ...Escherichia coliBiochem. Biophys. Res. Commun.374399-4042008------2--1---3--------1--------------------2---1----------1---------------
706851WU-Purification and enzymatic cha ...Acidithiobacillus ferrooxidansTrans. Nonferrous Met. Soc. China181450-14572008--1---11--1--1--1---2-1-1-1-1111-----11----1-1--1----1--2-1-1-1-111-------
671626CanalRegulation of the cysteine des ...Mus musculusArch. Biochem. Biophys.465282-2922007------3------4-----1-----------------------3-----------1------------------
672260YouA novel DNA modification by su ...Streptomyces lividansBiochemistry466126-61332007--1-1--2-112-5--1---4-101---2---1-----22-2----4-112---1--7-101---4----------
672277NeumannIdentification of a Rhodobacte ...Rhodobacter capsulatusBiochemistry469586-95952007--1--------2-3---1----21-------1-----11----------2--------21--------------
672753ZengExpression, purification and c ...Acidithiobacillus ferrooxidansBiotechnol. Lett.291983-19902007--11-----111-3--1---2231-------1-----111-------111---1--2231--------------
674798LayerSufE transfers sulfur from Suf ...Escherichia coliJ. Biol. Chem.28213342-133502007--1--------1-3--1-----11-------------1-----------1---1----11--------------
674877ZhaoEvidence for nifU and nifS par ...Klebsiella pneumoniaeJ. Biol. Chem.28237016-370252007-----------1-1--------1--------------------------1--------1---------------
676898Van HoewykChloroplast iron-sulfur cluste ...Arabidopsis thalianaProc. Natl. Acad. Sci. USA1045686-56912007----1---11---3--------------------------1-----11--------------------------
692336SendraThe SUF iron-sulfur cluster bi ...Escherichia coliFEBS Lett.5811362-13682007-----------1-3--------1--------------------------1--------1---------------
661595Adamthe Nfs1 interacting protein I ...Saccharomyces cerevisiaeEMBO J.25174-18320061-------1-1--5-11------1-----------1----------1-1---11-----1--------------
674271LundgrenStructural alterations of the ...Salmonella entericaJ. Bacteriol.1883052-30622006----1------1-3--------1-----------------1--------1--------1---------------
674541LiRoles of the mammalian cytosol ...Homo sapiensJ. Biol. Chem.28112344-123512006--------1----5--------11----------------------1-----------11--------------
674628FossetRNA silencing of mitochondrial ...Mus musculusJ. Biol. Chem.28125398-254062006----1--------3-----1--------------------1--------------1------------------
674773YeCpSufE activates the cysteine ...Arabidopsis thalianaJ. Biol. Chem.2818958-896920061------4-----4--------21-----------1---------4------------21--------------
675971BiederbickRole of human mitochondrial Nf ...Homo sapiens, Mus musculusMol. Cell. Biol.265675-56872006--1-2---3----6-----1-----------------1--2-----3--------1------------------
675989OnderModifications of the lipoamide ...Saccharomyces cerevisiaeMol. Cell. Proteomics51426-14362006----1---1--1-3--------1-----------------1-----1--1--------1---------------
661771ForlaniThe cysteine-desulfurase IscS ...Escherichia coliFEBS Lett.5796786-679020051----------1-4--------2------------1-------------1--------2---------------
662693LiewMitochondrial cysteine desulfu ...Rattus norvegicusJ. Nutr.1352151-21582005--1-----2-2--4--1--6-----------------1--------2-2----1-6------------------
663375RojasSensitivity to potassium tellu ...Escherichia coliRes. Microbiol.156465-4712005--1---1------4-----------------------1-----1------------------------------
660879KesslerSlr0077 of Synechocystis has c ...Synechocystis sp.Biochem. Biophys. Res. Commun.320571-5772004-----------1-4--1-----2--------------------------1---1----2---------------
661090TirupatiKinetic and structural charact ...Synechocystis sp.Biochemistry4312210-122192004---11-----11-5--1-----11-------1------111-------11---1----11--------------
661091BehshadMechanism of cysteine desulfur ...Synechocystis sp.Biochemistry4312220-122262004-----------1-3--1-----1--------1------1----------1---1----1---------------
662190NakaiYeast Nfs1p is involved in thi ...Saccharomyces cerevisiaeJ. Biol. Chem.27912363-123682004--------6----3--------------------------------6---------------------------
662209LauhonSubstitutions in an active sit ...Escherichia coliJ. Biol. Chem.27919551-195582004--1-2------1-2--1---5-1--------------1--2--------1---1--5-1---------------
662257MuhlenhoffFunctional characterization of ...Saccharomyces cerevisiaeJ. Biol. Chem.27936906-369152004--1-----3-21-3--1---1-22----1--------1--------3-21---1--1-22----1---------
645616Cupp-VickeryCrystal structure of IscS, a c ...Escherichia coliJ. Mol. Biol.3301049-10592003-----------1-4--------1--------1------1----------1--------1---------------
645619FrazzonFormation of iron-sulfur clust ...BacteriaCurr. Opin. Chem. Biol.7166-1732003---------1-1-1---1----11-------1------1--------1-1--------11--------------
645620KambampatiMnmA and IscS are required for ...Escherichia coliBiochemistry421109-11172003-----------2-3--------3--------------------------2--------3---------------
645628LoiseauBiogenesis of Fe-S cluster by ...Erwinia chrysanthemi, Escherichia coliJ. Biol. Chem.27838352-3835920032-1-1--12--2-6--12----4-1----------2-1--1----12--2---1----4-1-------------
645634OuttenThe SufE protein and the SufBC ...Escherichia coliJ. Biol. Chem.27845713-4571920032-1--------1-3--1---1-1------------2-1-----------1---1--1-1---------------
645638KuriharaAssembly of iron-sulfur cluste ...Escherichia coliBiochim. Biophys. Acta1647303-30920031----------2-3--1-----3------------1-------------2---1----3---------------
645639LaGierMitochondrial-type iron-sulfur ...Cryptosporidium parvumMicrobiology1493519-35302003--1-----1--1-5-----1--1--------------1--------1--1-----1--1---------------
645615MiharaBacterial cysteine desulfurase ...Azotobacter vinelandii, Escherichia coli, Haemophilus influenzae, Homo sapiens, Mus musculus, Pseudomonas aeruginosa, Saccharomyces cerevisiae, Synechocystis sp.Appl. Microbiol. Biotechnol.6012-232002--------3--11-9---2----17--------2------2-------3--11--------17---------------
645617LimaAnalysis of the E. coli NifS C ...Escherichia coliJ. Mol. Biol.3151199-12082002-------------1--------1-----------------------------------1---------------
645618LeonThe AtNFS2 gene from Arabidops ...Arabidopsis thalianaBiochem. J.366557-5642002--1-----1----1--1--------------1-----11-------1------1--------------------
645626LauhonRequirement for IscS in biosyn ...Escherichia coliJ. Bacteriol.1846820-68292002----1------1-3--------1-----------------1--------1--------1---------------
645630MiharaStructure of external aldimine ...Escherichia coliJ. Biochem.131679-6852002---13------1-1---1--1-3--------1------113--------1------1-3---------------
645633NilssonThe cysteine desulfurase IscS ...Escherichia coli, Salmonella entericaJ. Bacteriol.1846830-68352002-----------4-5--------4--------------------------4--------4---------------
645635YangRepair of nitric oxide-modifie ...Escherichia coliJ. Biol. Chem.27712868-128732002--1--------2-2--1-----2--------------1-----------2---1----2---------------
645614KiyasuContribution of cysteine desul ...Escherichia coli, Klebsiella pneumoniaeJ. Bacteriol.1822879-28852000--2------112-4--1-----21-------------2---------112---1----21--------------
645621KatoGene cloning, purification, an ...Synechocystis sp.Biosci. Biotechnol. Biochem.642412-241920002-1----4-121-1--1---4-611--42------2-1-------4-121---1--4-611--42---------
645627LauhonThe iscS gene in Escherichia c ...Escherichia coliJ. Biol. Chem.27520096-201032000----1------3-3--------4-----------------1--------3--------4---------------
645632MiharaKinetic and mutational studies ...Escherichia coliJ. Biochem.127559-56720001---3--8---1-4--1-----4------------1----3----8---1---1----4---------------
645637SchwartzThe cysteine desulfurase, IscS ...Escherichia coliProc. Natl. Acad. Sci. USA979009-90142000--1--------1-3--------1--------------1-----------1--------1---------------
645622KispalThe mitochondrial proteins Atm ...Saccharomyces cerevisiaeEMBO J.183981-39891999--------1--1-4--------1-----------------------1--1--------1---------------
645624LacourciereThe NIFS protein can function ...Azotobacter vinelandiiJ. Biol. Chem.27330921-309261998------11---2-1------2-4-1--2---------------1-1---2------2-4-1--2----------
645625LandTargeting of a human iron-sulf ...Homo sapiensMol. Cell2807-8151998--1-----3-1--3-----6-----------------1--------3-1------6------------------
645640Kirby-A cysteine desulphurase gene f ...Ruminococcus flavefaciensBiochim. Biophys. Acta1368233-2371998--1-------22-1--------2-1---1--------1----------22--------2-1---1---------
645636ZhengMechanism for the desulfurizat ...Azotobacter vinelandiiBiochemistry334714-47201994----1-21---2-1---1----3-1---1---1-------1--211---2--------3-1---1---------
645631ZhengCysteine desulfurase activity ...Azotobacter vinelandiiProc. Natl. Acad. Sci. USA902754-27581993--1---3---12-3--11----31-------1-----11----3----12---1----31--------------