Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate

Nakajima, H.; Toyoshima-Morimoto, F.; Taniguchi, E.; Nishida, E.; J. Biol. Chem. 278, 25277-25280 (2003)

 show all sequences of 2.7.11.21

Data extracted from this reference:

Cloned(Commentary)
Commentary Organism
expression of HA-tagged Plk in HeLa cells, co-expression of His-tagged Plk with wild-type and mutant Myt1 Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
ATP + Myt1 Homo sapiens phosphorylation of Myt1 during M phase ADP + phosphorylated Myt1
-
-
 ?
Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary Organism
recombinant HA-tagged Plk from HeLa cells by immunoprecipitation Homo sapiens
Reaction
Reaction Commentary Organism
ATP + a protein = ADP + a phosphoprotein the Plk consensus sequence is D/E-X-S/T-hydrophobic amino acid-X-D/E with X being any amino acid Homo sapiens
Source Tissue
Source Tissue Commentary Organism Textmining
HeLa cell
-
 Homo sapiens
-
Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
ATP + Myt1 phosphorylation of Myt1 during M phase 662142 Homo sapiens ADP + phosphorylated Myt1
-
-
-
 ?
ATP + Myt1 i.e. membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, no activity with a Myt1 mutant in which the 4 C-terminal phosphorylation sites are mutated to alanine 662142 Homo sapiens ADP + phosphorylated Myt1
-
-
-
 ?
More determination of enzyme consensus sequence 662142 Homo sapiens ?
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-
-
-
Cofactor
Cofactor Commentary Organism Structure
ATP
-
 Homo sapiens
Cloned(Commentary) (protein specific)
Commentary Organism
expression of HA-tagged Plk in HeLa cells, co-expression of His-tagged Plk with wild-type and mutant Myt1 Homo sapiens
Cofactor (protein specific)
Cofactor Commentary Organism Structure
ATP
-
 Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
ATP + Myt1 Homo sapiens phosphorylation of Myt1 during M phase ADP + phosphorylated Myt1
-
-
 ?
Purification (Commentary) (protein specific)
Commentary Organism
recombinant HA-tagged Plk from HeLa cells by immunoprecipitation Homo sapiens
Source Tissue (protein specific)
Source Tissue Commentary Organism Textmining
HeLa cell
-
 Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
ATP + Myt1 phosphorylation of Myt1 during M phase 662142 Homo sapiens ADP + phosphorylated Myt1
-
-
-
 ?
ATP + Myt1 i.e. membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, no activity with a Myt1 mutant in which the 4 C-terminal phosphorylation sites are mutated to alanine 662142 Homo sapiens ADP + phosphorylated Myt1
-
-
-
 ?
More determination of enzyme consensus sequence 662142 Homo sapiens ?
-
-
-
-

See also following references to EC number 2.7.11.21 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
702943UckunPolo-like-kinase 1 (PLK1) as a ...Homo sapiensBr. J. Haematol.148714-7252010------1---11-4--1--3--2--------1------1----1----11---1-3--2----------11---
703011DuanLentiviral shRNA screen of hum ...Homo sapiensCancer Lett.293220-2292010-11---1----1-3-----7--1--------1----111----1-----1-----7--1---------1--1--
703030GleixnerPolo-like kinase 1 (Plk1) as a ...Homo sapiensCancer Res.701513-15232010-1----2----1-3-1---2--1--------1----1-1----2-----1--1--2--1---------1--1--
703081ChunPolo-like kinase 1 enhances su ...Homo sapiensCarcinogenesis31785-7932010--1-2-1----1-4-----1--1-1---1--1-----11-2--1-----1-----1--1-1---1----11---
703107KeppnerBiological impact of freezing ...Homo sapiensCell Cycle9761-7732010-1--1-1----1-3-1---10--1-1------1--1-1-1-1-11-----1--1--10--1-1-------1111--
703258DegenhardtTargeting Polo-like kinase in ...Homo sapiensClin. Cancer Res.16384-3892010-1----4----1-3--------1--------1----1-1----4-----1--------1---------1111--
703519LiPolo-like kinase guides cytoki ...Trypanosoma bruceiEukaryot. Cell9705-7162010--1---2-4--1-3--1-----2-1---1--1--2--11---22--4--1---1----2-1---1----11---
703598ChopraPolo-like kinase inhibitors: a ...Homo sapiensExpert Opin. Invest. Drugs1927-43201021----13-1--1-3-1---6--1--------1--721-1---713--1--1--1--6--1---------1111--
704076ShiSignificance of Plk1 regulatio ...Homo sapiensInt. J. Cancer1262036-20482010-11---1----1-3-----3--1--------1----111----1-----1-----3--1---------2112--
704101LongSchistosoma mansoni Polo-like ...Schistosoma mansoniInt. J. Parasitol.401075-10862010111-4-4---11-4-1---1--1--------1-1-1111-4--4----11--1--1--1--------1-11---
705070BeriaIdentification of 4,5-dihydro- ...Homo sapiensJ. Med. Chem.533532-35512010-111--47----1-4--1-----1-1---1--1--79-1131--8181-----3---1----3-3---3---1111--
705620SillibourneAutophosphorylation of polo-li ...Homo sapiensMol. Biol. Cell21547-56120101-1-6-1-1--1-2-1---4--1-1------1---1-11-6--1--1--1--1--4--1-1--------11---
705801BenoitpH-responsive polymeric sirna ...Homo sapiensMol. Pharm.7442-4552010-1----1------3-----2----------------1------1-----------2------------1111--
705986AndrysikThe novel mouse Polo-like kina ...Homo sapiens, Mus musculusNucleic Acids Res.382931-294320101-1-----3-22-5--1--2--2--------2---1-12-------3-22---1-2--2---------------
706088SchmitModulating polo-like kinase 1 ...MammaliaPharm. Res.27989-998201021----12----1-2-1------1--------1--521-1---512-----1--1-----1---------2112--
706403VidanesCDC5 inhibits the hyperphospho ...Saccharomyces cerevisiaePLoS Biol.8e10002862010--1--------1-4--------1-----1--1-----11----------1--------1-----1----11---
694500TamuraPolo-like kinase 1 phosphoryla ...Homo sapiensOncogene28107-11620091-1---1-3--1-3--1--1--2-1---1------1-1-----1--3--1---1-1--2-1---1---------
702558EmmitteDesign of potent thiophene inh ...Homo sapiensBioorg. Med. Chem. Lett.191694-16972009-1----16----1-3-----6--1--------1--55-3-3---5548-----3-----6--3----------12---
702580SatoImidazopyridine derivatives as ...MammaliaBioorg. Med. Chem. Lett.194673-46782009-1----38----1-2--------1--------1--36-1-1---3638-----1--------1---------1111--
703018NappiIdentification of Polo-like ki ...Homo sapiensCancer Res.691916-19232009-1----1----1-2-----5--1-1---1--1--1-1-1---11-----1-----5--1-1---1---1111--
703026GilmartinDistinct concentration-depende ...Homo sapiensCancer Res.696969-69772009-1----1----1-3-----14--1-2---2--11---1-1----11----1-----14--1-2---2---1111--
703103SchmitPolo-like kinase 1 (Plk1) in n ...Homo sapiensCell Cycle82697-27022009-1----1----1-3-----6--1--------1----1-1----1-----1-----6--1---------1--1--
703224KeppnerIdentification and validation ...Homo sapiensChemMedChem41806-18092009-1----1----1-1-----1--1-1------1--1-1-1---11-----1-----1--1-1-------------
704521VitourPolo-like kinase 1 (PLK1) regu ...Homo sapiensJ. Biol. Chem.28421797-218092009-11-4-----11-3-----4--2--------1----111-4-------11-----4--2----------11---
704572DraghettiFunctional whole-genome analys ...Mus musculusJ. Biol. Chem.28432053-3206520096-----1----1-2-----2--1--------1---6--1----1-----1-----2--1---------------
705078WangInteraction between human papi ...Homo sapiensJ. Med. Virol.81536-5442009--1-5---2--1-6--1--2--2--------1-----11-5-----2--1---1-2--2----------11---
705617LiangThe molecular function of the ...Saccharomyces cerevisiaeMol. Biol. Cell203671-36792009----1------1-3--------1--------1------1-1--------1--------1----------11---
705692KishiFunctional dynamics of Polo-li ...Homo sapiensMol. Cell. Biol.293134-31502009--1-4---1--1-2--------1-1---1--1-----11-4-----1--1--------1-1---1----11---
705868ArchambaultPolo-like kinases: Conservatio ...Drosophila melanogaster, Homo sapiens, Saccharomyces cerevisiae, Saccharomyces pombe, Xenopus laevisNat. Rev. Mol. Cell Biol.10265-27520095----------5-5-5------5--------5---5--5----------5--5-----5---------1551--
706460SunPLK1 down-regulates parainflue ...Homo sapiensPLoS Pathog.5e10005252009-11-1-2----1-4--------2-1------1----111-1--2-----1--------2-1--------11---
706517ParkDirect quantification of polo- ...Homo sapiens, Mus musculusProc. Natl. Acad. Sci. USA1061725-17302009-2---------2-4-----14--4-2------2----2-2----------2-----14--4-2-------2--2--
690239EllingStructures of the wild-type an ...Danio rerio, Homo sapiensActa Crystallogr. Sect. D64909-9182008-2212-23--42-5--2-----4----32-------22-12--2-3--42---2----4----32---------
690267EllingStructure of the Brachydanio r ...Danio rerioActa Crystallogr. Sect. F64686-6912008-1111-1---11-5--1-----2-----1-------11-11--1----11---1----2-----1---------
691300HananDesign and synthesis of 2-amin ...Homo sapiensBioorg. Med. Chem. Lett.185186-51892008-1----14----1-3-----1--1-----------20-2-----2017-----2-----2--2---------------
691303FuciniDesign and synthesis of 2-amin ...Danio rerioBioorg. Med. Chem. Lett.185648-56522008-1-1--23----1-2--------1-----------23-1--1--2323-----1--------1---------------
691311CheungImidazo[5,1-f][1,2,4]triazin-2 ...MammaliaBioorg. Med. Chem. Lett.186214-62172008-1----25----1-1--------1-----------23-1-----2325-----1--------1---------------
691992NishiPolo kinases regulate C. elega ...Caenorhabditis elegans, Homo sapiensDevelopment135687-6972008--2-1---3--2-2--1--3--4--------1-----21-1-----3--2---1-3--4---------------
692140ParkRequirement for the budding ye ...Saccharomyces cerevisiaeEukaryot. Cell7444-4532008--1-1---3--1-3--------4--------1-----11-1-----3--1--------4---------------
692498ArchambaultSequestration of Polo kinase t ...Drosophila melanogasterGenes Dev.222707-27202008--1-3-1-6--1-2--1--3--1--------------1--3--1--6--1---1-3--1---------------
693194HigashimotoRegulation of IKK by phosphory ...Homo sapiensJ. Biol. Chem.28335354-3536720081-1-3------1-2--1--1--2-1---1------1-1--3--------1---1-1--2-1---1---------
693196ChiRequirements for protein phosp ...Homo sapiensJ. Biol. Chem.28335834-358442008----1-2-2--1-2-----1--2-----------------1--2--2--1-----1--2---------------
694161LuPolo-like kinase 1 is essentia ...Mus musculusMol. Cell. Biol.286870-68762008--------3--1-4-----4--6-----------------------3--1-----4--6---------------
694305CrastaInactivation of Cdh1 by synerg ...Saccharomyces cerevisiaeNat. Cell Biol.10665-6752008--1-1---3--1-4--1-----4-1---1--1-----11-1-----3--1---1----4-1---1---------
694505LiuPolo-like kinase 1 as a new ta ...Homo sapiensOncology7496-1032008-11---1----1-2-----4--1-------------11-----1-----1-----4--1---------------
694807Nakashima-The yeast Tor signaling pathwa ...Saccharomyces cerevisiaePLoS ONE31-112008--1-----2--1-1--------1-1---1--------1--------2--1--------1-1---1---------
678284KotheStructure of the catalytic dom ...Homo sapiensBiochemistry465960-59712007-1112-46---1-4--1----13----61-----8-12-24-95-12---1---2---13----111---------
678324JohnsonPharmacological and functional ...Homo sapiensBiochemistry469551-95632007-11---164-----5--1-----10---------41---42-----57564-------2----13---------------
679094ZimmermanFinding Plk3 ...Drosophila melanogaster, Homo sapiens, Saccharomyces cerevisiaeCell Cycle61314-13182007-31---2-5----5-----1--3-----------3-51----34--5--------3--3---------------
679095RandallPolo kinase and cytokinesis in ...Homo sapiensCell Cycle61713-17172007-1--1-4-3----3-----4--1-------------1---1--4--3--------4--1---------------
679108DaiPolo-like kinase 1 regulates R ...Homo sapiensCell Prolif.40550-5572007-2------3--1-4-----2--1-------------2---------4--1-----3--1---------------
679361LenartThe small-molecule inhibitor B ...Homo sapiensCurr. Biol.17304-3152007-1----1-3--1-2-----1--2-----------1-1-----11--3--1-----1--2---------------
679362PlytePLK1 inhibitors: setting the m ...Homo sapiens, Mus musculusCurr. Biol.17R280-R2832007-2----2------3-----1----------------2------2-----------1------------------
680011EloweTension-sensitive Plk1 phospho ...Homo sapiensGenes Dev.212205-22192007-1--1-1-1--1-1-----1--2-------------1---1--1--1--1-----1--2---------------
680773MatsumuraPolo-like kinase 1 facilitates ...Homo sapiens, Mus musculusJ. Biol. Chem.28215217-152272007-11---2-1----2-----3--2-------------11-----2--1--------3--2---------------
680810YuanPhospho-regulation of HsCdc14A ...Homo sapiensJ. Biol. Chem.28227414-274232007-11-2-1-4--1-4--1--2--3-------------12--2--2--6--1---2-2--3---------------
682002HammartonTrypanosoma brucei Polo-like k ...Trypanosoma bruceiMol. Microbiol.651229-12482007-11-1-1-2----3-----2--3-------------11--1--1--2--------2--3---------------
682039ZhangPolo-like kinase 1 may regulat ...Mus musculusMol. Reprod. Dev.741247-12542007-11---2---11-2-----4--2-1---1-----1-11----12----11-----4--2-1---1---------
682486BrennanPolo-like kinase controls vert ...Homo sapiensPLoS ONE2e4092007-1----4-3--1-3-----1--1-----------2-1-----26--3--1-----2--1---------------
682562Garcia-AlvarezMolecular and structural basis ...Homo sapiensProc. Natl. Acad. Sci. USA1043107-311220071-113---2--1-3-11--1--7-1------1---1-2225-----3--1--12-1--7-1-------------
682567BurkardChemical genetics reveals the ...Homo sapiensProc. Natl. Acad. Sci. USA1044383-43882007-11-2-1-2----3-----1--1--------1----111-2--1--2--------1--1---------------
694795XiangThe inhibition of polo kinase ...Drosophila melanogasterPLoS Biol.5e3232007--1---1-4--1-4-----3--2--------------1-----1--4--1-----3--2---------------
661596NishiyamaCell-cycle-dependent Xenopus T ...Xenopus laevisEMBO J.25575-5842006--------1--1-3-----1--2--------1------1-------1--1-----1--2---------------
663259HansenCaMKII and Polo-like kinase 1 ...Xenopus laevisProc. Natl. Acad. Sci. USA103608-6132006-1----1--2-3-2-----1--5-1---1--1----1-1----1---2-3-----1--5-1---1---------
677343Garcia-AlvarezCrystallization and preliminar ...Homo sapiensActa Crystallogr. Sect. F62372-3752006--11------1--4--1-----1--------------1-1--------1----1----1---------------
677916SatoPolo-like kinase and survivin ...Homo sapiensBiochem. Biophys. Res. Commun.342465-4712006-1-----------2-----13----------------1------------------13------------------
679091NishiyamaCell-cycle-dependent regulatio ...Xenopus sp.Cell Cycle51403-14062006-1-----------3-----1--1-------------1------------------1--1---------------
682090DarievaPolo kinase controls cell-cycl ...Saccharomyces cerevisiaeNature444494-4982006-11----------3--------2-------------11--------------------2---------------
682857YoshidaPolo-like kinase Cdc5 controls ...Saccharomyces cerevisiaeScience313108-1112006-1--1------2-3--------5-------------1---1--------2--------5---------------
661444RancatiMad3/BubR1 phosphorylation dur ...Saccharomyces cerevisiaeCell Cycle4972-9802005--1-----21-2-4--------3-1---1--1-----11-------21-2--------3-1---1---------
661534AhonenPolo-like kinase 1 creates the ...Homo sapiens, Xenopus laevisCurr. Biol.151078-10892005--1-1---61-4-4---1-5--6-----1--2-----12-1-----61-4-----5--6-----1---------
661560ClarkePOLO kinase regulates the Dros ...Drosophila melanogaster, Xenopus laevisDev. Cell853-642005--1-1------2-4-----2--4--------2-----12-1--------2-----2--4---------------
662420EckerdtPolo-like kinase 1-mediated ph ...Homo sapiensJ. Biol. Chem.28036575-365832005--1-3------1-3--1--3--3-1------1-----11-3--------1---1-3--3-1-------------
662436ZhangThe role of polo-like kinase 1 ...Homo sapiensJ. Biol. Chem.28042994-429992005--1-2-1--2-1-2-----2--3-1------1-----11-2--1---2-1-----2--3-1-------------
662946PetersenPolo kinase links the stress p ...Schizosaccharomyces pombeNature435507-5122005----1---1--1-3-1------1-----------------1-----1--1--1-----1---------------
662998GloverPolo kinase and progression th ...Drosophila melanogasterOncogene24230-2372005--1-11--6--4-3-----2--7--------1-----11-11----6--4-----2--7---------------
662999XieRegulation of cell cycle check ...Drosophila melanogaster, Homo sapiens, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Xenopus laevisOncogene24277-28620051-1-3-2-7--17-5-1-1-31-27--------5---1-15-3--2--7--17--1--31-27---------------
661532WarnkePolo-like kinase-2 is required ...Homo sapiensCurr. Biol.141200-120720041-1-2---22-1-3-----4--2-1---1--1---1-11-2-----22-1-----4--2-1---1---------
661533SumaraRoles of polo-like kinase 1 in ...Homo sapiensCurr. Biol.141712-17222004------1-5--1-2-----1--1--------------------1--5--1-----1--1---------------
661663RuanPolo-like kinase 3 is Golgi lo ...Homo sapiensExp. Cell Res.29451-592004--1-2---12-2-2--1--1--311---1--1-----11-2-----12-2---1-1--311---1---------
662229AndoPolo-like kinase 1 (Plk1) inhi ...Homo sapiensJ. Biol. Chem.27925549-255612004--1-1-2-11-2-3-----2--3--------1-----11-1--2--11-2-----2--3---------------
661448YaoPolo-like kinase-1 in porcine ...Sus scrofaCell. Mol. Biol.49399-4052003--------7--1-3-----5--1-----------------------7--1-----5--1---------------
661586ChengThe crystal structure of the h ...Homo sapiensEMBO J.225757-57682003--11--1-7--1-3--1-----1--------------1-1---1--7--1---1----1---------------
661827MacIverPhysical and functional intera ...Schizosaccharomyces pombeGenes Dev.171507-152320031---2---2--1-3--------2-1----------1----2-----2--1--------2-1-------------
662142NakajimaIdentification of a consensus ...Homo sapiensJ. Biol. Chem.27825277-252802003--1--------1-1--11-1--3--------1-----11----------1---1-1--3---------------
662181TsvetkovPolo-like kinase 1 and Chk2 in ...Homo sapiensJ. Biol. Chem.2788468-84752003--1-2---2--2-2--------3--------1-----11-2-----2--2--------3---------------
662497ReynoldsPolo boxes form a single funct ...Schizosaccharomyces pombeJ. Cell Sci.1161377-13872003--1-12---2--1-3--------21-------------1--12-----2--1--------21--------------
662809BachewichDepletion of a polo-like kinas ...Candida albicansMol. Biol. Cell142163-21802003----1---4--1-5--------1-----------------1-----4--1--------1---------------
662812VisintinThe role of the polo kinase Cd ...Saccharomyces cerevisiaeMol. Biol. Cell144486-44982003----1---1--1-4--------1-----------------1-----1--1--------1---------------
662924FanCharacterization of polo-like ...Rattus norvegicusMol. Reprod. Dev.65318-3292003--------6--1-3-----6--1-----------------------6--1-----6--1---------------
663203LiuPolo-like kinase (Plk)1 deplet ...Homo sapiensProc. Natl. Acad. Sci. USA1005789-57942003--1-1------1-3--------1--------------1--1--------1--------1---------------
663392LeeRole of polo-like kinase CDC5 ...Saccharomyces cerevisiaeScience300482-4862003----1---2--1-3--------1-----------------1-----2--1--------1---------------
491211WoodThe genome sequence of Schizos ...Schizosaccharomyces pombeNature415871-8802002-------------1------------------------------------------------------------
662496MulvihillCytokinetic actomyosin ring fo ...Schizosaccharomyces pombeJ. Cell Sci.1153575-35862002--------4--1-3--------11----------------------4--1--------11--------------
490160AdamsThe genome sequence of Drosoph ...Drosophila melanogasterScience2872185-21952000-------------1------------------------------------------------------------
491303HoltrichAdhesion induced expression of ...Homo sapiensOncogene194832-48392000--1----------3-----1-----------------1-----------------1------------------
491367ChaseThe polo-like kinase PLK-1 is ...Caenorhabditis elegansGenesis2626-412000--------2--1-4-----2--1-----------------------2--1-----2--1---------------
491438ChaseCaenorhabditis elegans contain ...Caenorhabditis elegansDNA Seq.11327-3342000-------------3------------------------------------------------------------
491305OuyangThe physical association and p ...Homo sapiensOncogene186029-60361999-----------1-1--------1--------------------------1--------1---------------
491368OuyangCaenorhabditis elegans contain ...Caenorhabditis elegansDNA Seq.10109-1131999-------------2------------------------------------------------------------
491439KauselmannThe polo-like protein kinases ...Rattus norvegicusEMBO J.185528-55391999-----------1-1--------1--------------------------1--------1---------------
491295Chase-Expression and phosphorylation ...Mus musculusBiochem. J.333655-6601998-----------1-1--------1--------------------------1--------1---------------
491306OuyangHuman Prk is a conserved prote ...Homo sapiensJ. Biol. Chem.27228646-286511997--1--------1-1--------3--------------1-----------1--------3---------------
491304LiPrk, a cytokine-inducible huma ...Homo sapiensJ. Biol. Chem.27119402-194081996-----------1-1-----1--1--------------------------1-----1--1---------------
491296DonohueIdentification by targeted dif ...Mus musculusJ. Biol. Chem.27010351-103571995-----------1-5--------1--------------------------1--------1---------------
491384OhkuraThe conserved Schizosaccharomy ...Schizosaccharomyces pombeGenes Dev.91059-10731995-----------1-1--------1--------------------------1--------1---------------
491369Wilson2.2 Mb of contiguous nucleotid ...Caenorhabditis elegansNature36832-381994-------------1------------------------------------------------------------
491394HoltrichInduction and down-regulation ...Homo sapiensProc. Natl. Acad. Sci. USA911736-17401994--1--------1-1-----4--1--------------1-----------1-----4--1---------------
491395HamanakaCloning and characterization o ...Homo sapiens, Mus musculusCell Growth Differ.5249-2571994--1----------7-----4-----------------1-----------------4------------------
491396Golsteyn-Cell cycle analysis and chromo ...Homo sapiensJ. Cell Sci.1071509-15171994--1--------1-1--------1--------------1-----------1--------1---------------
491433FodeSak, a murine protein-serine/t ...Mus musculusProc. Natl. Acad. Sci. USA916388-63921994--1--------1-5-----3--1--------------1-----------1-----3--1---------------
491362KitadaA multicopy suppressor gene of ...Saccharomyces cerevisiaeMol. Cell. Biol.134445-44571993-----------1-1--------2--------------------------1--------2---------------
491397LakeCell cycle- and terminal diffe ...Homo sapiens, Mus musculusMol. Cell. Biol.137793-78011993--1--------2-2--------2--------------1-----------2--------2---------------
491416ClayIdentification and cloning of ...Mus musculusProc. Natl. Acad. Sci. USA904882-48861993--1----------1-----------------------1------------------------------------
491398SimmonsIdentification of an early-gro ...Mus musculusMol. Cell. Biol.124164-41691992-------------1------------------------------------------------------------
491390LlamazaresPolo encodes a protein kinase ...Drosophila melanogasterGenes Dev.52153-21651991--1-----2--2-3-----2--2--------------1--------2--2-----2--2---------------