Regulation of the G2/M transition in Xenopus oocytes by the cAMP-dependent protein kinase

Eyers, P.A.; Liu, J.; Hayashi, N.R.; Lewellyn, A.L.; Gautier, J.; Maller, J.L.; J. Biol. Chem. 280, 24339-24346 (2005)

 show all sequences of 2.7.11.11

Data extracted from this reference:

Activating Compound
Activating Compound Commentary Organism Structure
cAMP dependent on Xenopus laevis
Cloned(Commentary)
Commentary Organism
expression of N-terminally His6-tagged wild-type and mutant catalytic subunits C in Escherichia coli strain BL21(DE3) Xenopus laevis
Engineering
Amino acid exchange Commentary Organism
D328A site-directed mutagenesis of the catalytic subunit, mutant shows decreased interaction with the regulatory RI subunit Xenopus laevis
D328A/K72H site-directed mutagenesis of the catalytic subunit, inactive mutant showing decreased interaction with the regulatory RII subunit Xenopus laevis
K72H site-directed mutagenesis of the catalytic subunit, inactive mutant Xenopus laevis
K72R site-directed mutagenesis of the catalytic subunit, inactive mutant Xenopus laevis
additional information microinjection of mutant subunits C in Xenopus oocytes, overview Xenopus laevis
R133A site-directed mutagenesis of the catalytic subunit, mutant shows decreased interaction with the regulatory RII subunit Xenopus laevis
R133A/K72H site-directed mutagenesis of the catalytic subunit, inactive mutant showing decreased interaction with the regulatory RII subunit Xenopus laevis
Inhibitors
Inhibitors Commentary Organism Structure
PKI recombinant His-tagged rabbit PKA inhibitor protein PKI, binding involves Arg133 Xenopus laevis
-
Metals/Ions
Metals/Ions Commentary Organism Structure
Mg2+
-
 Xenopus laevis
Natural Substrates/ Products (Substrates)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
More Xenopus laevis the enzyme regulates the G2/M transition in oocytes of Xenopus laevis, it also blocks progesterone-induced germinal vesicle envelope breakdown GVBD, Cdc-25-dependent dephosphorylation of Tyr15 in Cdc2, and synthesis of MEKK Mos ?
-
-
-
Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Xenopus laevis
-
-
-
Purification (Commentary)
Commentary Organism
recombinant N-terminally His6-tagged wild-type and mutant catalytic subunits C from Escherichia coli strain BL21(DE3) by nickel affinity chromatography Xenopus laevis
Source Tissue
Source Tissue Commentary Organism Textmining
oocyte
-
 Xenopus laevis
-
Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
ATP + Kemptide peptide substrate, activity of catalytic PKA subunit 662378 Xenopus laevis ADP + phosphorylated Kemptide
-
-
-
 ?
More the enzyme regulates the G2/M transition in oocytes of Xenopus laevis, it also blocks progesterone-induced germinal vesicle envelope breakdown GVBD, Cdc-25-dependent dephosphorylation of Tyr15 in Cdc2, and synthesis of MEKK Mos 662378 Xenopus laevis ?
-
-
-
-
Subunits
Subunits Commentary Organism
More Arg133 is essential for binding of the catalytic subunit C to the regulatory subunit RII Xenopus laevis
Temperature Optimum [°C]
Temperature Optimum [°C] Temperature Optimum Maximum [°C] Commentary Organism
30
-
 assay at Xenopus laevis
pH Optimum
pH Optimum Minimum pH Optimum Maximum Commentary Organism
7.4
-
 assay at Xenopus laevis
Cofactor
Cofactor Commentary Organism Structure
ATP
-
 Xenopus laevis
Activating Compound (protein specific)
Activating Compound Commentary Organism Structure
cAMP dependent on Xenopus laevis
Cloned(Commentary) (protein specific)
Commentary Organism
expression of N-terminally His6-tagged wild-type and mutant catalytic subunits C in Escherichia coli strain BL21(DE3) Xenopus laevis
Cofactor (protein specific)
Cofactor Commentary Organism Structure
ATP
-
 Xenopus laevis
Engineering (protein specific)
Amino acid exchange Commentary Organism
D328A site-directed mutagenesis of the catalytic subunit, mutant shows decreased interaction with the regulatory RI subunit Xenopus laevis
D328A/K72H site-directed mutagenesis of the catalytic subunit, inactive mutant showing decreased interaction with the regulatory RII subunit Xenopus laevis
K72H site-directed mutagenesis of the catalytic subunit, inactive mutant Xenopus laevis
K72R site-directed mutagenesis of the catalytic subunit, inactive mutant Xenopus laevis
additional information microinjection of mutant subunits C in Xenopus oocytes, overview Xenopus laevis
R133A site-directed mutagenesis of the catalytic subunit, mutant shows decreased interaction with the regulatory RII subunit Xenopus laevis
R133A/K72H site-directed mutagenesis of the catalytic subunit, inactive mutant showing decreased interaction with the regulatory RII subunit Xenopus laevis
Inhibitors (protein specific)
Inhibitors Commentary Organism Structure
PKI recombinant His-tagged rabbit PKA inhibitor protein PKI, binding involves Arg133 Xenopus laevis
-
Metals/Ions (protein specific)
Metals/Ions Commentary Organism Structure
Mg2+
-
 Xenopus laevis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
More Xenopus laevis the enzyme regulates the G2/M transition in oocytes of Xenopus laevis, it also blocks progesterone-induced germinal vesicle envelope breakdown GVBD, Cdc-25-dependent dephosphorylation of Tyr15 in Cdc2, and synthesis of MEKK Mos ?
-
-
-
Purification (Commentary) (protein specific)
Commentary Organism
recombinant N-terminally His6-tagged wild-type and mutant catalytic subunits C from Escherichia coli strain BL21(DE3) by nickel affinity chromatography Xenopus laevis
Source Tissue (protein specific)
Source Tissue Commentary Organism Textmining
oocyte
-
 Xenopus laevis
-
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
ATP + Kemptide peptide substrate, activity of catalytic PKA subunit 662378 Xenopus laevis ADP + phosphorylated Kemptide
-
-
-
 ?
More the enzyme regulates the G2/M transition in oocytes of Xenopus laevis, it also blocks progesterone-induced germinal vesicle envelope breakdown GVBD, Cdc-25-dependent dephosphorylation of Tyr15 in Cdc2, and synthesis of MEKK Mos 662378 Xenopus laevis ?
-
-
-
-
Subunits (protein specific)
Subunits Commentary Organism
More Arg133 is essential for binding of the catalytic subunit C to the regulatory subunit RII Xenopus laevis
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C] Temperature Optimum Maximum [°C] Commentary Organism
30
-
 assay at Xenopus laevis
pH Optimum (protein specific)
pH Optimum Minimum pH Optimum Maximum Commentary Organism
7.4
-
 assay at Xenopus laevis

See also following references to EC number 2.7.11.11 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
705261MatsumotoParathyroid hormone 2 receptor ...Mus musculusJ. Neurochem.112521-5302010------2------2--------1--------------------2--------------1---------------
708764DesiniotisEnhanced antiproliferative and ...Homo sapiensInt. J. Cancer126775-7892010-------------3-----3-----------2------2----------------3-------------11---
710589ItohEffects of cAMP-dependent prot ...Rattus norvegicusSynapse64172-17620101-----1------3-----1--1--------2---1--2----1-----------1--1----------11---
703141FunderudIsoform-specific regulation of ...Mus musculusCell. Signal.21274-2812009-------------3-----1-----------------------------------1-------------22---
710100PaineAttention deficits and hyperac ...Rattus norvegicusNeuropsychopharmacology342143-215520091-----1------3-----2--1--------2---1--2----1-----------2--1----------11---
690339Pastor-SolerAlkaline pH- and cAMP-induced ...Rattus norvegicusAm. J. Physiol. Cell Physiol.294C488-C49420081-----1------1-----2-----------1---1--1----1-----------2------------------
690353YangRegulation of transforming gro ...Mus musculusAm. J. Physiol. Gastrointest. Liver Physiol.295G170-G17820081-----2------1-----1-----------1---1--1----2-----------1------------------
690366KomalavilasThe small heat shock-related p ...Bos taurusAm. J. Physiol. Lung Cell Mol. Physiol.294L69-L7820082-----1------4-----3--1--------2---2--2----1-----------3--1---------------
690540GrosseProtein kinase A regulates gro ...Aspergillus fumigatusAppl. Environ. Microbiol.744923-49332008--1--------1-4--------2--------1-----11----------1--------2---------------
691022ShemetovPhosphorylation by cyclic AMP- ...Homo sapiensBiochemistry73200-2082008-------------3--------1--------2------2-------------------1---------------
691092TaylorSignaling through cAMP and cAM ...Homo sapiensBiochim. Biophys. Acta178416-262008------3------2--------1--------2------2----3--------------1---------------
691139WojtalcAMP-dependent protein kinase ...Rattus norvegicusBioessays30146-1552008--1-----5----1-----1--31-------2-----12-------5--------1--31--------------
691722De RasmocAMP-dependent protein kinase ...Bos taurusCell. Signal.20989-99720081-1---1------1--------2--------2---1-12----1--------------2---------------
692133MatsuoRegulation of the subcellular ...Schizosaccharomyces pombeEukaryot. Cell71450-14592008--------2----3-----------------2------2-------2---------------------------
692138Van de VeldeCyclic AMP-protein kinase A an ...Saccharomyces cerevisiaeEukaryot. Cell7286-29320082------------3-----------------2---2--2-----------------------------------
692212KleivelandHuman mesenchymal stem cell pr ...Homo sapiensExp. Cell Res.3141831-183820081-----2------3-----7--1--------2---1--2----2-----------7--1---------------
692216MukaiLocalized cyclic AMP-dependent ...Mus musculusExp. Cell Res.314387-39720081-----1-1----3-----3--1--------2---1--2----1--1--------3--1---------------
692294LarsenInactive forms of the catalyti ...Homo sapiensFEBS J.275250-2622008----1--------1-----2--2--------2------2-1--------------2--2---------------
692313BardalesIdentification of multiple iso ...Mytilus galloprovincialisFEBS J.2754479-44892008------15--5--2--1--3--11-------2------2----1-5--5----1-3--11--------------
692515CrawfordE-cadherin expression in postn ...Rattus norvegicusGlia561637-164720083-----2----1-2-----2--2--------2---3--2----2-----1-----2--2---------------
692602BaoRole of protein kinase A in Tr ...Trypanosoma cruziInfect. Immun.764757-47632008--1---2------4-----1--8--------2-----12----2-----------1--8---------------
693043de PinaSignaling the signal, cyclic A ...Bos taurus, Rattus norvegicusJ. Biol. Chem.28312373-1238620082---2-4-1----5--1--2--2--------4---2--4-2--4--1------1-2--2---------------
693123ManniPhosphorylation of the cAMP-de ...Rattus norvegicusJ. Biol. Chem.28324145-2415420084---2---1----3-----1--2--------2---4--2-2-----1--------1--2---------------
693126IslamcAMP-dependent protein kinase ...Homo sapiensJ. Biol. Chem.28325364-2537120081-----1----1-1-----1--1--------2---1--2----1-----1-----1--1---------------
693198BondThe Ras/cAMP/protein kinase A ...Saccharomyces cerevisiaeJ. Biol. Chem.28336513-3652120081-----1------1-----------------2---1--2----1------------------------------
693206HochbaumEpac, in synergy with cAMP-dep ...Rattus norvegicusJ. Biol. Chem.2834464-446820082-----1----1-2-----1--2--------2---2--2----1-----1-----1--2---------------
693219DammerPhosphorylation of CtBP1 by cA ...Homo sapiensJ. Biol. Chem.2836925-693420082------------3-----1--1--------2---2--2----------------1--1---------------
693323MustafaProtein kinase A and mitogen-a ...Rattus norvegicusJ. Cell. Physiol.215101-1102008------2------1-----2--1--------2------2----2-----------2--1---------------
693735TomimatsuSurvival-promoting activity of ...Rattus norvegicusJ. Neurochem.107628-6352008------2------1-----1-----------2------2----2-----------1------------------
693742ChatelierBiophysical properties of huma ...Homo sapiensJ. Neurophysiol.992241-22502008-------------1-----1-----------1------1----------------1------------------
693925FarquharProtein kinase A-dependent ste ...Homo sapiensJ. Virol.828797-8811200821----4------3-----1--1--------2---21-2----4-----------1--1---------------
694153DuProtein kinase A represses ske ...Mus musculusMol. Cell. Biol.282952-29702008-11----------1-----1--11-------2----112----------------1--11--------------
694155PetersenCyclic AMP (cAMP)-mediated sti ...Mus musculusMol. Cell. Biol.283804-3816200861----1------1-----2--2--------2---61-2----1-----------2--2---------------
694186DasCombinatorial roles of protein ...Homo sapiensMol. Endocrinol.22331-34320082-----2------1-----2--1--------2---2--2----2-----------2--1---------------
694279KanetoBicarbonate-induced phosphoryl ...Mus musculusMol. Reprod. Dev.751045-10532008------3----1-3-----2--2--------2------2----3-----1-----2--2---------------
694375AglahcAMP promotes neurite outgrowt ...Rattus norvegicusNeuropharmacology558-1720082-----2----1-1-----1--2--------2---2--2----2-----1-----1--2---------------
694404DaiA crucial role for cAMP and pr ...Homo sapiens, Rattus norvegicusNeurosignals16112-12320084-----4------2-----3-----------4---4--4----4-----------3------------------
694508GruebAdrenergic regulation of cAMP/ ...Bos taurusOphthalmic Res.40322-32820081-----1------3-----2--1--------2---1--2----1-----------2--1---------------
671678Zentella de PinaInhibition of cAMP-dependent p ...Bos taurus, Rattus norvegicusAuton. Autacoid. Pharmacol.2785-922007------10--1---2-----5-----------1------1----10---1-------5------------------
672227HallCritical role of cAMP-dependen ...Rattus norvegicusBiochemistry461635-164620072---1----1-3-5-----3--5--------1---2--1-1------1-3-----3--5---------------
672829ConranInhibition of caspase-dependen ...Homo sapiensBr. J. Haematol.139148-15820071-----1----1-3-----1--1--------1---1--1----1-----1-----1--1---------------
673601LombardoIn vitro embryonic development ...Danio rerioFEBS J.274485-49720071-----1--1-1-6-----1--2--------1---1--1----1---1-1-----1--2---------------
674804SchaubleIdentification of ChChd3 as a ...Mus musculusJ. Biol. Chem.28214952-1495920071-1-1-3511---3-11--11-4-1--41--3---1-13-1--3-511----11-11-4-1--41---------
674837HumphriesRedox regulation of cAMP-depen ...Homo sapiensJ. Biol. Chem.28222072-2207920075-----2-12-1-2-----1--2-----1--1---5--1----2--12-1-----1--2-----1---------
675021Regimbald-DumascAMP-dependent protein kinase ...Rattus norvegicusJ. Cell. Biochem.101609-61820071--------1-1-2-----3--2-1---1--1---1--1--------1-1-----3--2-1---1---------
675671ScholtenDiversity of cAMP-dependent pr ...Mus musculusJ. Proteome Res.61705-171720071-1-----11-1-3-1---3--11-------1---1-11-------11-1--1--3--11--------------
675892BorthwickThe formation of the cAMP/prot ...Homo sapiensMol. Biol. Cell183388-339720071-----1-1--1-2-----1--1--------1---1--1----1--1--1-----1--1---------------
677061Abu-AbedDefinition of an electrostatic ...Bos taurusProteins69112-12420071---1---1----1--------11-------1---1--1-1-----1-----------11--------------
677184Jin-Role of phosphorylated Thr-197 ...Mus musculusTheochem8059-152007---1-----1---1---1-------------1------11-------1--------------------------
662674ZhangA transitory activation of pro ...Homo sapiensJ. Neural Transm.21-1120063-------11-2-1-----2--4-1---1--1---3--1-------11-2-----2--4-1---1---------
663349VigilA simple electrostatic switch ...Bos taurusProtein Sci.15113-12120061-1-4----1---2--11----21-------1---1-11-4------1-----1----21--------------
671598BejarCatalytic subunit of cAMP-depe ...Mytilus galloprovincialisArch. Biochem. Biophys.450133-1402006------2---15-3--1--3--81-------1------1----2----15---1-3--81--------------
672647UngE230Q mutation of the catalyti ...Mus musculusBiopolymers81428-4392006---11-1--1---1--------21-------1------111--1---1----------21--------------
673011BowenExpression of multiple isoform ...Caenorhabditis briggsae, Caenorhabditis elegansCell. Signal.182230-22372006--2----------6-----4---2-------------2-----------------4---2--------------
673668SardanelliOccurrence of A-kinase anchor ...Rattus norvegicusFEBS Lett.5805690-56962006--------3----3-----3---2----------------------3--------3---2--------------
673866DeminoffUsing substrate-binding varian ...Saccharomyces cerevisiaeGenetics1731909-19172006----3--1-1-1-3---1----2--------1------1-3----1-1-1--------2---------------
675598KimAugmentation of Cav3.2 T-type ...Xenopus laevisJ. Pharmacol. Exp. Ther.318230-23720062---1-21-1---1-----1--4--------1---2--1-1--2-1-1-------1--4---------------
675873TabishMolecular characterisation of ...Amblyomma hebraeumMol. Biochem. Parasitol.150330-3392006--1--------1-3-1---6--11-------------1-----------1--1--6--11--------------
676192Rengamma-Hydroxybutyrate induces ...Mus musculusNeuroscience141269-27520061-----1-11-1-5-----4--2-----1--1---1--1----1--11-1-----4--2-----1---------
677019ChengHow does activation loop phosp ...Homo sapiensProtein Sci.15672-68320061---2----1---1-1------11-------1---1--1-2------1----1-----11--------------
661013SoulsbyThe type III inositol 1,4,5-tr ...Homo sapiensBiochem. J.392493-49720053--------1-1-2-----1--2-1------1---3--1--------1-1-----1--2-1-------------
661266LoogComparison of cAMP-dependent p ...Zea maysBiochim. Biophys. Acta1747261-26620051------1-1---2--------3-1---1--1---1--1------1-1----------3-1---1---------
661501SatoMitochondrial Ca2+-activated K ...Cavia porcellusCirculation111198-20320053----------1-3-----2--1------------3-------------1-----2--1---------------
661558SuTandem mass spectrometry ident ...Strongylocentrotus purpuratusDev. Biol.285116-12520052-----5--2-9-2-----2--18-1---1--1---2--1----5---2-9-----2--18-1---1---------
661688OrstavikIdentification and characteriz ...Homo sapiensFEBS J.2721559-156720052-------1----3-----4---2----1------2----------1--------4---2----1---------
661759LangerFolding and activity of cAMP-d ...Cricetulus griseusFEBS Lett.5794049-40542005111-4----1---3-11--1--211---1--1---1111-4------1----11-1--211---1---------
662347VisteSubstrate enhances the sensiti ...Bos taurus, Homo sapiensJ. Biol. Chem.28013279-1328420052-----2--2---3-----2--4--------2---2--2----2---2-------2--4---------------
662378EyersRegulation of the G2/M transit ...Xenopus laevisJ. Biol. Chem.28024339-2434620051-1-7-1--1-1-2--1--2--211---1--1---1-11-7--1---1-1---1-2--211---1---------
662380JungmannCyclic AMP and AKAP-mediated t ...Rattus norvegicusJ. Biol. Chem.28025170-2517720051-------11-2-1--1--2--31-------1---1--1-------11-2---1-2--31--------------
662386D'SouzaPhosphorylation of claudin-3 a ...Homo sapiensJ. Biol. Chem.28026233-2624020052-----1--1-2-2-----17--5-1---1--1---2--1----1---1-2-----17--5-1---1---------
662393HornerPhosphorylation of GRK1 and GR ...Bos taurus, Homo sapiensJ. Biol. Chem.28028241-2825020053--------2-6-4-----4--10-2---2--2---3--2--------2-6-----4--10-2---2---------
662452IyerConsequences of lysine 72 muta ...Mus musculusJ. Biol. Chem.2808800-880720051-1-6-1--1---1-1------2-1------1---1-11-6--1---1----1-----2-1-------------
662681ChaubeCyclic AMP-protein kinase A an ...Heteropneustes fossilisJ. Neuroendocrinol.1791-9620052-----1--1-1-3-----5--2--------1---2--1----1---1-1-----5--2---------------
662708LiuStimulation of beta-adrenocept ...Oryctolagus cuniculusJ. Physiol.562395-40620052-----2--1-1-3-----5--1-1---1--1---2--1----2---1-1-----5--1-1---1---------
662709SedejcAMP increases Ca2+-dependent ...Mus musculusJ. Physiol.567799-81320052-------11-1-1-----21-1--------1---2--1-------11-1-----21-1---------------
662873LecureuilFollicle-stimulating hormone a ...Rattus norvegicusMol. Endocrinol.191812-182020053--------1-2-1-----1--2--------1---3--1--------1-2-----1--2---------------
663236BudovskayaAn evolutionary proteomics app ...Saccharomyces cerevisiaeProc. Natl. Acad. Sci. USA10213933-1393820051-1-----11-1-3--------3-1------1---1-11-------11-1--------3-1-------------
663237HoweSpatial regulation of the cAMP ...Homo sapiens, Rattus norvegicusProc. Natl. Acad. Sci. USA10214320-143252005------2----2-3-----2--6--------2------2----2-----2-----2--6---------------
663344WuCrystal structure of the E230Q ...Mus musculusProtein Sci.142871-287920051-111-1--1---2-111----1--------1---1-1111--1---1----11----1---------------
663394KimCrystal structure of a complex ...Mus musculusScience307690-69620051--1--2--1---1---------1-------1---1--11---2---1-----------1--------------
660803BardalesIsoforms of cAMP-dependent pro ...Mytilus galloprovincialisArch. Biochem. Biophys.43271-7820043------1-1---3--1--31-1111--1--1---3--1------1-1-----1-31-1111--1---------
661135VigilDifferential effects of substr ...Bos taurusBiochemistry435629-563620041-1------1---2---11---21-------1---1-11--------1------1---21--------------
661143WuCrystal structures of RIalpha ...Bos taurusBiochemistry436620-662920041-11--2------3--1------1-----------1-1-1---2---------1-----1--------------
661314KuznetsovKinetic analysis of inhibition ...Homo sapiensBioorg. Chem.32527-53520041-----11-1---1---1----1-1---1--12--1--1----121-1----------1-1---1---------
661480LangerNMR backbone assignment of a p ...Rattus norvegicusChemBioChem51508-15162004--1-3-1--1---2---------1----1--12----11-3--12--1-----------1----1---------
661746LeboulleSynergistic activation of inse ...Apis melliferaFEBS Lett.576216-22020043-1------1---2--1-11--111---1--1---3-11--------1-----111--111---1---------
661884PatelcAMP-dependent protein kinase ...Manduca sextaInsect Biochem. Mol. Biol.341269-127920042-----8311-1-3--1--21-721---1--111-2--1----81311-1---1-21-721---1--1------
662206AlfthanCyclic AMP-dependent protein k ...Homo sapiensJ. Biol. Chem.27918559-1856620041-1---1--1-2-1-----1--3-1---1--1---1-11----1---1-2-----1--3-1---1---------
662212GardnerRole of the cyclic AMP-depende ...Homo sapiensJ. Biol. Chem.27921135-2114320041---1-2-11-1-1-----1--2--------1---1--1-1--2--11-1-----1--2---------------
662279ConstantinescucAMP-dependent protein kinase ...Rattus norvegicusJ. Biol. Chem.27943321-4332920042-------21-3-2-----1--3-1---1--1---2--1-------21-3-----1--3-1---1---------
662302LiuTau becomes a more favorable s ...Rattus norvegicusJ. Biol. Chem.27950078-50088200421----1-11-2-1-----2--4-1---1--1---21-1----1--11-2-----2--4-1---1---------
662321ZawadzkicAMP-dependent protein kinase ...Rattus norvegicusJ. Biol. Chem.2797029-703620041-1-3--1-1---2--1-1----2-------1---1-11-3----1-1-----11----2--------------
662614YangCrystal structure of a cAMP-de ...Mus musculusJ. Mol. Biol.336473-4872004--111-1--1---2--11----1--------1-----1111--1---1-----1----1---------------
662675SuraEffects of phosphorylation by ...Rattus norvegicusJ. Neurochem.90970-97820041--------1---1--------1-1---1--1---1--1--------1----------1-1---1---------
662851LeeNegative regulation of histone ...Homo sapiensMol. Cell. Biol.24765-77320042-----1--1-1-1-----1--2-1------1---2--1----1---1-1-----1--2-1-------------
663212TianDistinct stoichiometry of BKCa ...Bos taurus, Homo sapiensProc. Natl. Acad. Sci. USA10111897-1190220042--------2-1-3-----1--4-2---2--2---2--2--------2-1-----1--4-2---2---------
663295ZhangCharacterization of the cAMP-d ...Homo sapiens, Mus musculusProtein Expr. Purif.35156-16920042-2---412-4---2--2---311442---2--2---2-22----4-12-4-----2--311442---2---------
395498BoeckmannThe SWISS-PROT protein knowled ...Mus musculusNucleic Acids Res.31365-3702003-------------1------------------------------------------------------------
490931Adams JosephActivation loop phosphorylatio ...eukaryotaBiochemistry42601-60720032--12-11-1-1-1-1-1----2--------1---2--112--1-1-1-1--1-----2---------------
660567FrajntThe effect of cAMP and cGMP on ...Pichia pastorisActa Biochim. Pol.501111-111820035--------1---5-11-----1011---1--1---5--1--------1----11----1011---1---------
660660BarmancAMP activates BKCa channels i ...Rattus norvegicusAm. J. Physiol.284L1004-101120032-----2----1-3-----2--1------------2-------2-----1-----2--1---------------
660682MurthySelective phosphorylation of t ...Oryctolagus cuniculusAm. J. Physiol. Gastronintest. Liver Physiol.284G221-23020035-----1--1-1-1-----2--2-1---1--1---5--1----1---1-1-----2--2-1---1---------
660791Diaz-EnrichCharacterization of a type I r ...Mytilus galloprovincialisArch. Biochem. Biophys.416119-12720031--------1---3--1-----131---1--1-2-1--1--------1-----1----131---1--2------
660948BainThe specificities of protein k ...Bos taurusBiochem. J.371199-20420031-----5------1----------1---1--1---1--1----5----------------1---1---------
660951BiondiSignalling specificity of Ser/ ...Homo sapiensBiochem. J.3721-132003-----11------1--------11-------1------1--1-1--------------11--------------
661073HollingerPhosphorylation of RGS14 by pr ...Rattus norvegicusBiochemistry42811-81920032-----1--1-1-2---1-1--21-------1---2--1----1---1-1-----1--21--------------
662153RapacciuoloProtein kinase A and G protein ...Homo sapiensJ. Biol. Chem.27835403-3541120032---1-2-1--1-1-----11-2-1---1--1---2--1-1--2--1--1-----11-2-1---1---------
662154ZhouCharacterization of protein ki ...Oryctolagus cuniculusJ. Biol. Chem.27835651-3565920031-------11-1-1-----3--2-1---1--1---1--1-------11-1-----3--2-1---1---------
662158PiontekDifferential and regulated bin ...Homo sapiensJ. Biol. Chem.27838970-3897920031-------1--1-2-----2--11-----------1----------1--1-----2--11--------------
662180SewercAMP-dependent protein kinase ...Homo sapiensJ. Biol. Chem.2788106-811120032--------1-1-3-----2--2-1---1--1---2--1--------1-1-----2--2-1---1---------
662491WestcGMP-dependent and not cAMP-de ...Rattus norvegicusJ. Cardiovasc. Pharmacol.41444-45120034-----1--1-1-1-----1--1--------1---4--1----1---1-1-----1--1---------------
662608AkamineDynamic features of cAMP-depen ...Mus musculusJ. Mol. Biol.327159-17120031-11--1--1---2-111----22-------1---1-111---1---1----11----22--------------
490935AdamsKinetic and catalytic mechanis ...eukaryotaChem. Rev.1012271-229020012--1--41-4-1-1-1-1----42-------1---2--11---4-1-4-1--1-----42--------------
490160AdamsThe genome sequence of Drosoph ...Drosophila melanogasterScience2872185-21952000-------------1-----------------1------1-----------------------------------
490980AgustinThe unique catalytic subunit o ...Homo sapiensMol. Biol. Cell113031-30442000-----------1-4-----2--1--------1------1----------1-----2--1--