Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: Illuminating the role of main-chain reorganization

Godsey, M.H.; Ort, S.; Sabini, E.; Konrad, M.; Lavie, A.; Biochemistry 45, 452-461 (2006)

Data extracted from this reference:

Cloned(Commentary)

Commentary	Organism
expressed of engineered protein as His-tag fusion protein in Escherichia coli	Homo sapiens

Crystallization (Commentary)

Crystallization	Organism
hanging drop vapour diffusion method, in complex with deoxycytidine (dC) and UDP, and in the presence of deoxycytidine but the absence of UDP or ADP	Homo sapiens

Engineering

Amino acid exchange	Commentary	Organism
DEL65-79	construction of an enzyme variant lacking a flexible insert (residues 65-79) but having similar catalytic properties as the wild type	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Commentary	Organism	Structure
0.001	-	2'-deoxycytidine	less than 0.001 mM, residues 65-79 deletion mutant with UTP as cosubstrate; less than 0.001 mM, wild type enzyme with ATP as cosubstrate; less than 0.001 mM, wild type enzyme with UTP as cosubstrate	Homo sapiens
0.0014	-	2'-deoxycytidine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens
0.0015	-	UTP	residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.0023	-	UTP	wild type enzyme deletion mutant with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.0029	-	ATP	residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.003	-	1-beta-D-arabinofuranosylcytosine	residues 65-79 deletion mutant with UTP as cosubstrate; wild type enzyme with UTP as cosubstrate	Homo sapiens
0.0035	-	ATP	wild type enzyme with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.0047	-	UTP	residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.007	-	1-beta-D-arabinofuranosylcytosine	wild type enzyme with ATP as cosubstrate	Homo sapiens
0.01	-	UTP	wild type enzyme deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.013	-	1-beta-D-arabinofuranosylcytosine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens
0.013	-	2'-deoxyadenosine	wild type enzyme with UTP as cosubstrate	Homo sapiens
0.021	-	2'-deoxyguanosine	wild type enzyme with UTP as cosubstrate	Homo sapiens
0.053	-	2'-deoxyadenosine	residues 65-79 deletion mutant with UTP as cosubstrate	Homo sapiens
0.053	-	ATP	residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.087	-	2'-deoxyguanosine	residues 65-79 deletion mutant with UTP as cosubstrate	Homo sapiens
0.093	-	ATP	wild type enzyme with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.1	-	2'-deoxyadenosine	wild type enzyme with ATP as cosubstrate	Homo sapiens
0.231	-	2'-deoxyguanosine	wild type enzyme with ATP as cosubstrate	Homo sapiens
0.415	-	2'-deoxyadenosine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens
0.474	-	2'-deoxyguanosine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Commentary (Nat. Sub.)	Natural Products	Commentary (Nat. Pro.)	Organism (Nat. Pro.)	Reversibility
NTP + 1-beta-D-arabinofuranosylcytosine	Homo sapiens	antineoplastic agent	NDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate	-	-	?
NTP + 2',3'-dideoxycytidine	Homo sapiens	antiviral agent	NDP + 2',3'-dideoxycytidine 5'-phosphate	-	-	?
NTP + 2'-deoxy-3'-thiacytidine	Homo sapiens	antiviral agent	NDP + 2'-deoxy-3'-thiacytidine 5'-phosphate	-	-	?
NTP + 2'-deoxyadenosine	Homo sapiens	rate-limiting reaction in the salvage of deoxyribonucleosides	NDP + 2'-deoxyadenosine 5'-phosphate	-	-	?
NTP + 2'-deoxycytidine	Homo sapiens	rate-limiting reaction in the salvage of deoxyribonucleosides	NDP + 2'-deoxycytidine 5'-phosphate	-	-	?
NTP + 2'-deoxyguanosine	Homo sapiens	rate-limiting reaction in the salvage of deoxyribonucleosides	NDP + 2'-deoxyguanosine 5'-phosphate	-	-	?
NTP + 2-chloro-2'-deoxyadenosine	Homo sapiens	i.e. cladribine, antineoplastic agent	NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate	-	-	?

Organism

Organism	Primary Accession No. (UniProt)	Commentary	Textmining
Homo sapiens	P27707	-	-

Purification (Commentary)

Commentary	Organism
recombinant protein using His-tag	Homo sapiens

Substrates and Products (Substrate)

Substrates	Commentary Substrates	Literature (Substrates)	Organism	Products	Commentary (Products)	Literature (Products)	Organism (Products)	Reversibility
NTP + 1-beta-D-arabinofuranosylcytosine	antineoplastic agent	672149	Homo sapiens	NDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate	-	-	-	?
NTP + 2',3'-dideoxycytidine	antiviral agent	672149	Homo sapiens	NDP + 2',3'-dideoxycytidine 5'-phosphate	-	-	-	?
NTP + 2'-deoxy-3'-thiacytidine	antiviral agent	672149	Homo sapiens	NDP + 2'-deoxy-3'-thiacytidine 5'-phosphate	-	-	-	?
NTP + 2'-deoxyadenosine	rate-limiting reaction in the salvage of deoxyribonucleosides	672149	Homo sapiens	NDP + 2'-deoxyadenosine 5'-phosphate	-	-	-	?
NTP + 2'-deoxycytidine	rate-limiting reaction in the salvage of deoxyribonucleosides	672149	Homo sapiens	NDP + 2'-deoxycytidine 5'-phosphate	-	-	-	?
NTP + 2'-deoxyguanosine	rate-limiting reaction in the salvage of deoxyribonucleosides	672149	Homo sapiens	NDP + 2'-deoxyguanosine 5'-phosphate	-	-	-	?
NTP + 2-chloro-2'-deoxyadenosine	i.e. cladribine, antineoplastic agent	672149	Homo sapiens	NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate	-	-	-	?

Subunits

Subunits	Commentary	Organism
dimer	2 * 30500, calculated from the deduced amino acid sequence, crystal structure analysis	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Commentary	Organism	Structure
0.028	-	ATP	wild type enzyme with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.031	-	UTP	wild type enzyme deletion mutant with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.033	-	2'-deoxycytidine	less than 0.001 mM, wild type enzyme with ATP as cosubstrate	Homo sapiens
0.039	-	ATP	residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.041	-	UTP	residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.044	-	2'-deoxycytidine	less than 0.001 mM, wild type enzyme with UTP as cosubstrate	Homo sapiens
0.049	-	2'-deoxycytidine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens
0.075	-	UTP	residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.088	-	2'-deoxycytidine	less than 0.001 mM, residues 65-79 deletion mutant with UTP as cosubstrate	Homo sapiens
0.093	-	UTP	wild type enzyme deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.15	-	1-beta-D-arabinofuranosylcytosine	residues 65-79 deletion mutant with UTP as cosubstrate	Homo sapiens
0.17	-	1-beta-D-arabinofuranosylcytosine	wild type enzyme with UTP as cosubstrate	Homo sapiens
0.3	-	1-beta-D-arabinofuranosylcytosine	wild type enzyme with ATP as cosubstrate	Homo sapiens
0.31	-	2'-deoxyadenosine	residues 65-79 deletion mutant with UTP as cosubstrate	Homo sapiens
0.32	-	2'-deoxyguanosine	residues 65-79 deletion mutant with UTP as cosubstrate	Homo sapiens
0.33	-	2'-deoxyadenosine	wild type enzyme with UTP as cosubstrate	Homo sapiens
0.33	-	2'-deoxyguanosine	wild type enzyme with UTP as cosubstrate	Homo sapiens
0.36	-	ATP	residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.4	-	ATP	wild type enzyme with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.41	-	1-beta-D-arabinofuranosylcytosine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens
1.7	-	2'-deoxyadenosine	wild type enzyme with ATP as cosubstrate	Homo sapiens
2.2	-	2'-deoxyguanosine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens
2.6	-	2'-deoxyguanosine	wild type enzyme with ATP as cosubstrate	Homo sapiens
2.8	-	2'-deoxyadenosine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens

Cofactor

Cofactor	Commentary	Organism	Structure
ATP	-	Homo sapiens
UTP	preferred phosphoryl group donor	Homo sapiens

Cloned(Commentary) (protein specific)

Commentary	Organism
expressed of engineered protein as His-tag fusion protein in Escherichia coli	Homo sapiens

Cofactor (protein specific)

Cofactor	Commentary	Organism	Structure
ATP	-	Homo sapiens
UTP	preferred phosphoryl group donor	Homo sapiens

Crystallization (Commentary) (protein specific)

Crystallization	Organism
hanging drop vapour diffusion method, in complex with deoxycytidine (dC) and UDP, and in the presence of deoxycytidine but the absence of UDP or ADP	Homo sapiens

Engineering (protein specific)

Amino acid exchange	Commentary	Organism
DEL65-79	construction of an enzyme variant lacking a flexible insert (residues 65-79) but having similar catalytic properties as the wild type	Homo sapiens

KM Value [mM] (protein specific)

KM Value [mM]	KM Value Maximum [mM]	Substrate	Commentary	Organism	Structure
0.001	-	2'-deoxycytidine	less than 0.001 mM, residues 65-79 deletion mutant with UTP as cosubstrate; less than 0.001 mM, wild type enzyme with ATP as cosubstrate; less than 0.001 mM, wild type enzyme with UTP as cosubstrate	Homo sapiens
0.0014	-	2'-deoxycytidine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens
0.0015	-	UTP	residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.0023	-	UTP	wild type enzyme deletion mutant with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.0029	-	ATP	residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.003	-	1-beta-D-arabinofuranosylcytosine	residues 65-79 deletion mutant with UTP as cosubstrate; wild type enzyme with UTP as cosubstrate	Homo sapiens
0.0035	-	ATP	wild type enzyme with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.0047	-	UTP	residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.007	-	1-beta-D-arabinofuranosylcytosine	wild type enzyme with ATP as cosubstrate	Homo sapiens
0.01	-	UTP	wild type enzyme deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.013	-	1-beta-D-arabinofuranosylcytosine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens
0.013	-	2'-deoxyadenosine	wild type enzyme with UTP as cosubstrate	Homo sapiens
0.021	-	2'-deoxyguanosine	wild type enzyme with UTP as cosubstrate	Homo sapiens
0.053	-	2'-deoxyadenosine	residues 65-79 deletion mutant with UTP as cosubstrate	Homo sapiens
0.053	-	ATP	residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.087	-	2'-deoxyguanosine	residues 65-79 deletion mutant with UTP as cosubstrate	Homo sapiens
0.093	-	ATP	wild type enzyme with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.1	-	2'-deoxyadenosine	wild type enzyme with ATP as cosubstrate	Homo sapiens
0.231	-	2'-deoxyguanosine	wild type enzyme with ATP as cosubstrate	Homo sapiens
0.415	-	2'-deoxyadenosine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens
0.474	-	2'-deoxyguanosine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens

Natural Substrates/ Products (Substrates) (protein specific)

Natural Substrates	Organism	Commentary (Nat. Sub.)	Natural Products	Commentary (Nat. Pro.)	Organism (Nat. Pro.)	Reversibility
NTP + 1-beta-D-arabinofuranosylcytosine	Homo sapiens	antineoplastic agent	NDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate	-	-	?
NTP + 2',3'-dideoxycytidine	Homo sapiens	antiviral agent	NDP + 2',3'-dideoxycytidine 5'-phosphate	-	-	?
NTP + 2'-deoxy-3'-thiacytidine	Homo sapiens	antiviral agent	NDP + 2'-deoxy-3'-thiacytidine 5'-phosphate	-	-	?
NTP + 2'-deoxyadenosine	Homo sapiens	rate-limiting reaction in the salvage of deoxyribonucleosides	NDP + 2'-deoxyadenosine 5'-phosphate	-	-	?
NTP + 2'-deoxycytidine	Homo sapiens	rate-limiting reaction in the salvage of deoxyribonucleosides	NDP + 2'-deoxycytidine 5'-phosphate	-	-	?
NTP + 2'-deoxyguanosine	Homo sapiens	rate-limiting reaction in the salvage of deoxyribonucleosides	NDP + 2'-deoxyguanosine 5'-phosphate	-	-	?
NTP + 2-chloro-2'-deoxyadenosine	Homo sapiens	i.e. cladribine, antineoplastic agent	NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate	-	-	?

Purification (Commentary) (protein specific)

Commentary	Organism
recombinant protein using His-tag	Homo sapiens

Substrates and Products (Substrate) (protein specific)

Substrates	Commentary Substrates	Literature (Substrates)	Organism	Products	Commentary (Products)	Literature (Products)	Organism (Products)	Reversibility
NTP + 1-beta-D-arabinofuranosylcytosine	antineoplastic agent	672149	Homo sapiens	NDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate	-	-	-	?
NTP + 2',3'-dideoxycytidine	antiviral agent	672149	Homo sapiens	NDP + 2',3'-dideoxycytidine 5'-phosphate	-	-	-	?
NTP + 2'-deoxy-3'-thiacytidine	antiviral agent	672149	Homo sapiens	NDP + 2'-deoxy-3'-thiacytidine 5'-phosphate	-	-	-	?
NTP + 2'-deoxyadenosine	rate-limiting reaction in the salvage of deoxyribonucleosides	672149	Homo sapiens	NDP + 2'-deoxyadenosine 5'-phosphate	-	-	-	?
NTP + 2'-deoxycytidine	rate-limiting reaction in the salvage of deoxyribonucleosides	672149	Homo sapiens	NDP + 2'-deoxycytidine 5'-phosphate	-	-	-	?
NTP + 2'-deoxyguanosine	rate-limiting reaction in the salvage of deoxyribonucleosides	672149	Homo sapiens	NDP + 2'-deoxyguanosine 5'-phosphate	-	-	-	?
NTP + 2-chloro-2'-deoxyadenosine	i.e. cladribine, antineoplastic agent	672149	Homo sapiens	NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate	-	-	-	?

Subunits (protein specific)

Subunits	Commentary	Organism
dimer	2 * 30500, calculated from the deduced amino acid sequence, crystal structure analysis	Homo sapiens

Turnover Number [1/s] (protein specific)

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Commentary	Organism	Structure
0.028	-	ATP	wild type enzyme with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.031	-	UTP	wild type enzyme deletion mutant with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.033	-	2'-deoxycytidine	less than 0.001 mM, wild type enzyme with ATP as cosubstrate	Homo sapiens
0.039	-	ATP	residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.041	-	UTP	residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate	Homo sapiens
0.044	-	2'-deoxycytidine	less than 0.001 mM, wild type enzyme with UTP as cosubstrate	Homo sapiens
0.049	-	2'-deoxycytidine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens
0.075	-	UTP	residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.088	-	2'-deoxycytidine	less than 0.001 mM, residues 65-79 deletion mutant with UTP as cosubstrate	Homo sapiens
0.093	-	UTP	wild type enzyme deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.15	-	1-beta-D-arabinofuranosylcytosine	residues 65-79 deletion mutant with UTP as cosubstrate	Homo sapiens
0.17	-	1-beta-D-arabinofuranosylcytosine	wild type enzyme with UTP as cosubstrate	Homo sapiens
0.3	-	1-beta-D-arabinofuranosylcytosine	wild type enzyme with ATP as cosubstrate	Homo sapiens
0.31	-	2'-deoxyadenosine	residues 65-79 deletion mutant with UTP as cosubstrate	Homo sapiens
0.32	-	2'-deoxyguanosine	residues 65-79 deletion mutant with UTP as cosubstrate	Homo sapiens
0.33	-	2'-deoxyadenosine	wild type enzyme with UTP as cosubstrate	Homo sapiens
0.33	-	2'-deoxyguanosine	wild type enzyme with UTP as cosubstrate	Homo sapiens
0.36	-	ATP	residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.4	-	ATP	wild type enzyme with 1-beta-D-arabinofuranosylcytosine as cosubstrate	Homo sapiens
0.41	-	1-beta-D-arabinofuranosylcytosine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens
1.7	-	2'-deoxyadenosine	wild type enzyme with ATP as cosubstrate	Homo sapiens
2.2	-	2'-deoxyguanosine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens
2.6	-	2'-deoxyguanosine	wild type enzyme with ATP as cosubstrate	Homo sapiens
2.8	-	2'-deoxyadenosine	residues 65-79 deletion mutant with ATP as cosubstrate	Homo sapiens

See also following references to EC number 2.7.1.74 (sorted by year of publication):

No.	1st author	Pub Med	title	organims	journal	volume	pages	year	Activating Compound	Application	Cloned(Commentary)	Crystallization (Commentary)	Engineering	General Stability	Inhibitors	KM Value [mM]	Localization	Metals/Ions	Molecular Weight [Da]	Natural Substrates/ Products (Substrates)	Organic Solvent Stability	Organism	Oxidation Stability	Posttranslational Modification	Purification (Commentary)	Reaction	Renatured (Commentary)	Source Tissue	Specific Activity [micromol/min/mg]	Storage Stability	Substrates and Products (Substrate)	Subunits	Temperature Optimum [�C]	Temperature Range [�C]	Temperature Stability [�C]	Turnover Number [1/s]	pH Optimum	pH Range	pH Stability	Cofactor	Ki Value [mM]	pI Value	IC50 Value	Activating Compound (protein specific)	Application (protein specific)	Cloned(Commentary) (protein specific)	Cofactor (protein specific)	Crystallization (Commentary) (protein specific)	Engineering (protein specific)	General Stability (protein specific)	IC50 Value (protein specific)	Inhibitors (protein specific)	Ki Value [mM] (protein specific)	KM Value [mM] (protein specific)	Localization (protein specific)	Metals/Ions (protein specific)	Molecular Weight [Da] (protein specific)	Natural Substrates/ Products (Substrates) (protein specific)	Organic Solvent Stability (protein specific)	Oxidation Stability (protein specific)	Posttranslational Modification (protein specific)	Purification (Commentary) (protein specific)	Renatured (Commentary) (protein specific)	Source Tissue (protein specific)	Specific Activity [micromol/min/mg] (protein specific)	Storage Stability (protein specific)	Substrates and Products (Substrate) (protein specific)	Subunits (protein specific)	Temperature Optimum [�C] (protein specific)	Temperature Range [�C] (protein specific)	Temperature Stability [�C] (protein specific)	Turnover Number [1/s] (protein specific)	pH Optimum (protein specific)	pH Range (protein specific)	pH Stability (protein specific)	pI Value (protein specific)	Expression	General Information	General Information (protein specific)	Expression (protein specific)	KCat/KM [mM/s]	KCat/KM [mM/s] (protein specific)
704730	Yu		Novel potent inhibitors of deo ...	Homo sapiens	J. Biomol. Screen.	15	72-79	2010	-	-	1	-	-	-	2	1	-	-	-	1	-	2	-	-	1	-	-	-	-	-	8	-	-	-	-	-	-	-	-	1	-	-	2	-	-	1	1	-	-	-	2	2	-	1	-	-	-	1	-	-	-	1	-	-	-	-	8	-	-	-	-	-	-	-	-	-	-	1	1	-	-	-
706027	Funamizu		Is the resistance of gemcitabi ...	Homo sapiens	Oncol. Rep.	23	471-475	2010	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	4	-	-	2	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	4	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
706844	Mirzaee		Differences in cytosolic and m ...	Mus musculus, Rattus norvegicus	Toxicology	267	159-164	2010	-	-	-	-	-	-	-	-	2	-	-	-	-	2	-	-	-	-	-	26	-	-	2	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	2	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	26	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
702271	Hazra		Extending thymidine kinase act ...	Homo sapiens	Biochemistry	48	1256-1263	2009	-	-	1	1	2	-	-	19	2	-	-	4	-	3	-	-	1	-	-	-	-	-	6	-	-	-	-	19	-	-	-	1	-	-	-	-	-	1	1	1	2	-	-	-	-	19	2	-	-	4	-	-	-	1	-	-	-	-	6	-	-	-	-	19	-	-	-	-	-	-	-	-	19	19
702603	Tarver		5-Fluorocytosine derivatives a ...	Mus musculus	Bioorg. Med. Chem. Lett.	19	6780-6783	2009	-	-	-	-	-	-	33	-	-	-	-	-	-	3	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	1	-	-	33	-	-	-	1	-	-	-	33	33	-	-	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
702604	Jessop		Lead optimization and structur ...	Homo sapiens	Bioorg. Med. Chem. Lett.	19	6784-6787	2009	-	-	-	-	-	-	23	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	25	-	-	-	1	-	-	-	25	23	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
703020	Costantino		The role of HuR in gemcitabine ...	Homo sapiens	Cancer Res.	69	4567-4572	2009	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	1	-	-	2	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	2	-	-	-	-	-	-	-	-	-	2	-	-	2	-	-
704900	Shord		Paclitaxel alters the expressi ...	Homo sapiens	J. Exp. Clin. Cancer Res.	28	76	2009	1	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	3	-	-	2	-	-	-	-	-	-	-	-	1	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	2	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-
690454	Ohhashi		Down-regulation of deoxycytidi ...	Homo sapiens	Anticancer Res.	28	2205-2212	2008	-	1	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
690954	Iyidogan		Systematic exploration of acti ...	Homo sapiens	Biochemistry	47	4711-4720	2008	-	-	-	-	11	-	-	45	-	-	-	-	-	3	-	-	-	-	-	-	28	-	8	-	-	-	-	44	-	-	-	-	-	-	-	-	-	-	-	-	11	-	-	-	-	45	-	-	-	-	-	-	-	-	-	-	28	-	8	-	-	-	-	44	-	-	-	-	-	-	-	-	-	-
691590	Szatmari		Adenoviral vector transduction ...	Homo sapiens	Cancer Gene Ther.	15	154-164	2008	-	1	1	-	-	-	-	-	-	-	-	-	-	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
692040	Kocabas		Gemcitabine pharmacogenomics: ...	Homo sapiens	Drug Metab. Dispos.	36	1951-1959	2008	-	-	1	-	1	-	-	1	-	-	-	-	-	2	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
692364	McSorley		Mimicking phosphorylation of S ...	Homo sapiens	FEBS Lett.	582	720-724	2008	-	-	1	-	4	-	-	10	1	-	-	-	-	3	-	1	-	-	-	-	-	-	5	1	-	-	-	23	-	-	-	-	-	-	-	-	-	1	-	-	4	-	-	-	-	10	1	-	-	-	-	-	1	-	-	-	-	-	5	1	-	-	-	23	-	-	-	-	-	-	-	-	-	-
693554	Sabini		Elucidation of different bindi ...	Homo sapiens	J. Med. Chem.	51	4219-4225	2008	-	-	-	1	-	-	-	6	-	-	-	-	-	3	-	-	-	-	-	-	-	-	6	-	-	-	-	6	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	6	-	-	-	-	-	-	-	-	-	-	-	-	6	-	-	-	-	6	-	-	-	-	-	-	-	-	-	-
694483	Joachims		Inhibition of deoxynucleoside ...	Homo sapiens	Nucleosides Nucleotides Nucleic Acids	27	816-820	2008	-	1	-	-	-	-	1	-	-	-	-	-	-	2	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	1	-	1	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	1	1	-	-	-
703425	Kim		Twenty novel genetic variation ...	Homo sapiens	Drug Metab. Pharmacokinet.	23	379-384	2008	-	-	-	-	1	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
671801	Fyrberg		Cell cycle effect on the activ ...	Homo sapiens	Biochem. Biophys. Res. Commun.	357	847-853	2007	-	-	-	-	-	-	-	-	-	-	-	1	-	3	-	-	-	-	-	4	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	4	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
672894	Smal		Positive regulation of deoxycy ...	Homo sapiens	Cancer Lett.	253	68-73	2007	5	2	1	-	-	-	-	-	-	1	-	2	-	2	-	1	-	-	-	3	-	-	3	-	-	-	-	-	-	-	-	1	-	-	-	5	2	1	1	-	-	-	-	-	-	-	-	1	-	2	-	-	1	-	-	3	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
675605	Lamba		Pharmacogenetics of deoxycytid ...	Homo sapiens	J. Pharmacol. Exp. Ther.	323	935-945	2007	-	1	1	-	4	-	-	3	-	1	-	1	-	4	-	-	-	-	-	3	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	1	1	-	-	7	-	-	-	-	3	-	1	-	1	-	-	-	-	-	3	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
676221	Sabini		Structural basis for activatio ...	Homo sapiens	Nucleic Acids Res.	35	186-192	2007	-	-	1	1	1	-	-	15	-	1	-	3	-	4	-	-	1	-	-	-	-	-	15	-	-	-	-	23	-	-	-	2	-	-	-	-	-	1	2	2	2	-	-	-	-	15	-	1	-	3	-	-	-	1	-	-	-	-	15	-	-	-	-	23	-	-	-	-	-	-	-	-	-	-
690229	Soriano		Structures of human deoxycytid ...	Homo sapiens	Acta Crystallogr. Sect. D	63	1201-1207	2007	-	-	1	1	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
690849	Rylova		Expression of deoxynucleoside ...	Mus musculus	Biochem. Pharmacol.	74	169-175	2007	-	-	-	-	-	-	-	-	-	-	-	-	-	4	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
693531	Sabini		Nonenantioselectivity property ...	Homo sapiens	J. Med. Chem.	50	3004-3014	2007	-	-	-	1	1	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
671043	Zhang		The structure of human deoxycy ...	Homo sapiens	Acta Crystallogr. Sect. D	62	133-139	2006	-	-	1	1	-	-	-	-	-	-	-	4	-	3	-	-	1	-	-	-	-	-	4	1	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	-	-	-	-	-	-	-	-	4	-	-	-	1	-	-	-	-	4	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
672137	Mani		Fluorescence energy transfer s ...	Homo sapiens	Biochemistry	45	3534-3541	2006	-	-	1	-	2	-	-	8	-	-	-	1	-	3	-	-	1	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	2	-	-	-	-	8	-	-	-	1	-	-	-	1	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
672149	Godsey		Structural basis for the prefe ...	Homo sapiens	Biochemistry	45	452-461	2006	-	-	1	1	1	-	-	21	-	-	-	7	-	3	-	-	1	-	-	-	-	-	7	1	-	-	-	24	-	-	-	2	-	-	-	-	-	1	2	1	1	-	-	-	-	21	-	-	-	7	-	-	-	1	-	-	-	-	7	1	-	-	-	24	-	-	-	-	-	-	-	-	-	-
672797	Pauwels		The relation between deoxycyti ...	Homo sapiens	BMC Cancer	6	142	2006	-	-	-	-	-	-	-	-	-	-	-	1	-	3	-	-	-	-	-	8	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	8	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
672879	Bierau		Cyclopentenyl cytosine-induced ...	Homo sapiens	Cancer Chemother. Pharmacol.	57	105-113	2006	1	-	-	-	-	-	-	-	-	-	-	1	-	3	-	-	-	-	-	3	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	3	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
673119	Sebastiani		Immunohistochemical and geneti ...	Homo sapiens	Clin. Cancer Res.	12	2492-2497	2006	-	-	-	-	-	-	-	-	1	-	-	1	-	3	-	-	-	-	-	10	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	-	-	-	10	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
674748	Smal		Identification of in vivo phos ...	Homo sapiens	J. Biol. Chem.	281	4887-4893	2006	-	-	1	-	8	-	1	1	-	-	1	13	-	2	-	1	1	-	-	3	-	-	14	1	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	8	-	-	1	-	1	-	-	1	13	-	-	1	1	-	3	-	-	14	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
676242	Sigmond		Enhanced activity of deoxycyti ...	Homo sapiens	Nucleosides Nucleotides Nucleic Acids	25	1177-1180	2006	1	-	-	-	-	-	-	-	-	-	-	2	-	1	-	1	-	-	-	1	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	1	-	-	1	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
676245	Fyrberg		Cell cycle dependent regulatio ...	Homo sapiens	Nucleosides Nucleotides Nucleic Acids	25	1201-1204	2006	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
660812	Keszler		Activation of deoxycytidine ki ...	Homo sapiens	Arch. Biochem. Biophys.	436	69-77	2005	9	-	-	-	-	-	1	-	-	1	-	2	-	2	-	-	-	-	-	2	1	-	4	-	-	-	-	-	1	-	-	1	-	-	-	9	-	-	1	-	-	-	-	1	-	-	-	1	-	2	-	-	-	-	-	2	1	-	4	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-
661040	Rylova		Activity profiles of deoxynucl ...	Homo sapiens	Biochem. Pharmacol.	69	951-960	2005	-	-	1	-	-	-	-	-	1	1	-	-	-	3	-	-	-	-	-	3	2	-	1	-	-	-	-	-	1	-	-	1	-	-	-	-	-	1	1	-	-	-	-	-	-	-	1	1	-	-	-	-	-	-	-	3	2	-	1	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-
661330	Johnsamuel		Docking simulation with a puri ...	Homo sapiens	Bioorg. Med. Chem.	13	4160-4167	2005	-	-	-	1	-	-	-	-	-	1	-	2	-	3	-	-	-	1	-	-	-	-	6	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	1	1	-	-	-	-	-	-	-	1	-	2	-	-	-	-	-	-	-	-	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
662521	Hubeek		Immunocytochemical detection o ...	Homo sapiens	J. Clin. Pathol.	58	695-699	2005	-	-	-	-	-	-	-	-	-	1	-	3	-	4	-	-	-	-	-	7	-	-	3	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	3	-	-	-	-	-	7	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
661034	Feng		Anabolism of amdoxovir: phosph ...	Homo sapiens	Biochem. Pharmacol.	68	1879-1888	2004	-	-	-	-	-	-	-	-	-	1	-	1	-	6	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	1	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
661731	Piskur		Animal deoxyribonucleoside kin ...	Homo sapiens, Mus musculus	FEBS Lett.	560	3-6	2004	-	-	-	-	2	-	-	-	2	2	-	8	-	2	-	-	-	-	-	-	-	-	8	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	2	-	2	-	-	-	-	-	2	2	-	8	-	-	-	-	-	-	-	-	8	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
662988	Mani		Fluorescence studies of substr ...	Homo sapiens	Nucleosides Nucleotides Nucleic Acids	23	1343-1346	2004	-	-	-	-	-	-	1	1	-	1	-	7	-	3	-	-	-	-	-	-	-	-	22	-	-	-	-	-	-	-	-	2	1	-	-	-	-	-	2	-	-	-	-	1	1	1	-	1	-	7	-	-	-	-	-	-	-	-	22	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
662989	Hubeek		Immunocytochemical detection o ...	Homo sapiens	Nucleosides Nucleotides Nucleic Acids	23	1351-1356	2004	-	-	-	-	-	-	-	-	-	1	-	3	-	2	-	-	-	-	-	3	1	-	4	-	1	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	3	-	-	-	-	-	3	1	-	4	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-
662992	Al-Madhoun		Phosphorylation of isocarbosty ...	Homo sapiens	Nucleosides Nucleotides Nucleic Acids	23	1865-1874	2004	-	-	-	-	-	-	-	2	3	1	-	1	-	2	-	-	-	-	-	-	1	-	4	-	1	-	-	2	1	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	-	2	3	1	-	1	-	-	-	-	-	-	1	-	4	-	1	-	-	2	1	-	-	-	-	-	-	-	-	-
641957	Csapo		Activation of deoxycytidine ki ...	Homo sapiens	Biochem. Pharmacol.	65	2031-2039	2003	2	-	-	-	-	-	1	-	1	-	-	-	-	4	-	1	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	1	-	-	1	-	-	-	-	-	1	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641966	Mani		Hydrodynamic and spectroscopic ...	Homo sapiens	Nucleosides, Nucleotides Nucleic Acids	22	175-192	2003	-	-	-	-	-	-	-	-	-	-	1	-	-	3	-	-	-	1	-	1	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641970	Someya		Phosphorylation of 4'-thio-bet ...	Homo sapiens	J. Pharmacol. Exp. Ther.	304	1314-1322	2003	-	-	-	-	-	-	4	7	-	-	-	1	-	3	-	-	-	-	-	-	-	-	5	-	-	-	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	4	4	-	7	-	-	-	1	-	-	-	-	-	-	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641973	Keszler		Selective activation of deoxyc ...	Homo sapiens	Biochem. Pharmacol.	65	563-571	2003	1	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
663023	Van Rompay		Substrate specificity and phos ...	Homo sapiens	Pharmacol. Ther.	100	119-139	2003	-	1	1	-	-	-	-	-	2	1	-	7	-	1	-	-	-	-	-	6	-	-	15	-	-	-	-	-	-	-	-	2	-	-	-	-	1	1	2	-	-	-	-	-	-	-	2	1	-	7	-	-	-	-	-	6	-	-	15	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
671908	Van den Neste		Activation of deoxycytidine ki ...	Homo sapiens	Biochem. Pharmacol.	65	573-580	2003	4	-	-	-	-	-	1	-	-	-	-	1	-	2	-	1	-	-	-	2	-	-	2	-	-	-	-	-	-	-	-	1	-	-	-	4	-	-	1	-	-	-	-	1	-	-	-	-	-	1	-	-	1	-	-	2	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
671911	Smal		Activation of deoxycytidine ki ...	Homo sapiens	Biochem. Pharmacol.	69	95-103	2003	6	-	-	-	-	-	3	-	-	-	-	9	-	2	-	1	-	-	-	2	-	-	10	-	-	-	-	-	-	-	-	2	-	-	-	6	-	-	2	-	-	-	-	3	-	-	-	-	-	9	-	-	1	-	-	2	-	-	10	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641955	Beausejour		Cytotoxic activity of 2',2'-di ...	Mus musculus	Biochem. Biophys. Res. Commun.	293	1478-1484	2002	-	1	-	-	-	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
661453	Eriksson		Structure and function of cell ...	Homo sapiens	Cell. Mol. Life Sci.	59	1327-1346	2002	-	-	1	-	-	-	1	1	2	1	-	2	-	1	-	1	-	1	-	7	1	-	22	1	-	-	-	-	-	-	-	3	-	-	-	-	-	1	3	-	-	-	-	1	-	1	2	1	-	2	-	-	1	-	-	7	1	-	22	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641954	Csapo		Activation of deoxycytidine ki ...	Homo sapiens	Biochem. Pharmacol.	61	191-197	2001	1	1	-	-	-	-	-	-	1	-	-	-	-	3	-	1	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	1	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641972	Csapo		Modulation of human deoxycytid ...	Homo sapiens	Acta Biochim. Pol.	48	251-256	2001	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641969	Spasokoukotskaja		Effect of phosphorylation on d ...	Homo sapiens	Adv. Exp. Med. Biol.	486	281-285	2000	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	1	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
640557	Gaubert		Low enantioselectivities of hu ...	Homo sapiens	Biochimie	81	1041-1047	1999	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641956	Spasokoukotskaja		Treatment of normal and malign ...	Homo sapiens	Eur. J. Cancer	35	1862-1867	1999	6	-	-	-	-	-	-	-	1	-	-	-	-	2	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	6	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641959	Wang		Stereoisomeric selectivity of ...	Homo sapiens	Biochemistry	38	16993-16999	1999	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641965	Kierdaszuk		Substrate/inhibitor properties ...	Homo sapiens	Nucleosides Nucleotides	18	1883-1903	1999	-	-	-	-	-	-	4	-	-	-	-	-	-	3	-	-	-	-	-	2	-	-	12	-	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	4	4	-	-	-	-	-	-	-	-	-	-	2	-	-	12	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641971	Shafiee	-	Study of human deoxycytidine k ...	Homo sapiens	Eur.J.Med.Chem.	34	423-431	1999	1	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	1	1	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	1	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641960	Hatzis		The intracellular localization ...	Homo sapiens	J. Biol. Chem.	273	30239-30243	1998	-	-	-	-	-	-	-	-	2	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641968	Spasokoukotskaja		Activation of deoxycytidine ki ...	Homo sapiens	Adv. Exp. Med. Biol.	431	641-645	1998	4	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641958	Hughes		Kinetic analysis of human deox ...	Homo sapiens	Biochemistry	36	7540-7547	1997	1	-	-	-	-	-	4	5	-	-	-	-	-	3	-	-	-	1	-	-	-	-	3	-	-	-	-	-	-	-	-	-	4	-	-	1	-	-	-	-	-	-	-	4	4	5	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641961	Usova		The effects of high salt conce ...	Homo sapiens	Eur. J. Biochem.	248	762-766	1997	1	-	-	-	-	-	1	-	-	-	1	-	-	3	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	1	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641963	Eriksson	-	Substrate specificities, expre ...	Homo sapiens	Nucleosides Nucleotides	16	653-659	1997	-	-	-	-	-	-	-	-	1	-	-	-	-	1	-	-	-	-	-	1	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641964	Shafiee	-	Study of the enantioselectivit ...	Homo sapiens	Nucleosides Nucleotides	16	1767-1770	1997	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641953	Johansson		Differences in kinetic propert ...	Homo sapiens, Mus musculus	Biochem. Pharmacol.	50	163-168	1995	-	-	2	-	-	-	2	20	-	-	-	-	-	5	-	-	-	-	-	-	-	-	10	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	2	-	20	-	-	-	-	-	-	-	-	-	-	-	-	10	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641967	Kim	-	Purification of deoxycytidine ...	Homo sapiens	J. Biochem. Mol. Biol.	28	281-289	1995	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	2	-	-	3	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-	3	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
640566	Ikeda		Heterodimeric deoxynucleoside ...	Lactobacillus acidophilus	Biochemistry	33	5328-5334	1994	-	-	-	-	-	-	-	-	-	1	-	-	-	1	-	-	1	-	-	-	-	-	2	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	-	2	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641938	Wang		Purification and characterizat ...	Homo sapiens	Biochim. Biophys. Acta	1202	309-316	1993	5	-	-	-	-	-	14	3	2	-	1	-	-	3	-	-	1	-	-	3	2	-	24	1	1	-	-	-	-	-	-	-	-	-	-	5	-	-	-	-	-	-	-	14	-	3	2	-	1	-	-	-	-	1	-	3	2	-	24	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-
641946	Shewach		Nucleotide specificity of huma ...	Homo sapiens	Mol. Pharmacol.	42	518-524	1992	-	-	-	-	-	-	1	-	-	-	-	-	-	3	-	-	-	-	-	2	-	-	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	2	-	-	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641939	Eriksson		Characterization of human deox ...	Homo sapiens	FEBS Lett.	280	363-366	1991	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	2	1	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	1	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641947	Habteyesus		Deoxynucleoside phosphorylatin ...	Aotus trivirgatus, Homo sapiens, Mus musculus	Biochem. Pharmacol.	42	1829-1836	1991	-	-	-	-	-	-	-	-	7	-	-	3	-	6	-	-	1	-	-	10	-	-	10	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	7	-	-	3	-	-	-	1	-	10	-	-	10	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641937	Kierdaszuk		Selective inactivation of the ...	Homo sapiens	Biochemistry	29	4109-4114	1990	3	-	-	-	-	2	1	1	-	1	-	1	-	4	-	-	-	-	-	4	-	1	6	-	1	1	3	-	-	-	-	-	-	-	-	3	-	-	-	-	-	2	-	1	-	1	-	1	-	1	-	-	-	-	-	4	-	1	6	-	1	1	3	-	-	-	-	-	-	-	-	-	-	-
641940	Kim		Human deoxycytidine kinase: ki ...	Homo sapiens	Biochemistry	28	9043-9047	1989	-	-	-	-	-	-	2	1	-	1	-	-	-	3	-	-	-	1	-	1	-	-	2	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	1	-	1	-	-	-	-	-	-	-	1	-	-	2	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-
641941	Datta		Kinetic properties and inhibit ...	Homo sapiens	J. Biol. Chem.	264	9359-9364	1989	-	-	-	-	-	-	22	6	-	1	-	-	-	3	-	-	1	-	-	3	1	-	6	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	22	-	6	-	1	-	-	-	-	-	1	-	3	1	-	6	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-
641942	Datta		Human T-lymphoblast deoxycytid ...	Homo sapiens	Biochemistry	28	114-123	1989	-	-	-	-	-	2	11	5	-	8	1	-	-	4	-	-	1	-	-	3	4	1	11	1	1	-	-	-	1	1	-	-	-	-	-	-	-	-	-	-	-	2	-	11	-	5	-	8	1	-	-	-	-	1	-	3	4	1	11	1	1	-	-	-	1	1	-	-	-	-	-	-	-	-
641943	Bohman		Deoxycytidine kinase from huma ...	Homo sapiens	Biochemistry	27	4258-4265	1988	1	-	-	-	-	-	4	5	1	1	1	-	-	3	-	-	1	-	-	4	1	2	7	1	1	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	-	-	4	-	5	1	1	1	-	-	-	-	1	-	4	1	2	7	1	1	-	-	-	1	-	-	-	-	-	-	-	-	-
641944	Kim		Affinity purification of human ...	Homo sapiens	Biochem. Biophys. Res. Commun.	156	92-98	1988	-	-	-	-	-	-	-	3	-	-	1	-	-	3	-	-	1	-	-	1	-	-	10	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	1	-	-	-	-	1	-	1	-	-	10	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-
641079	Yamada		Purine nucleoside kinases in h ...	Homo sapiens	Biochim. Biophys. Acta	761	34-40	1983	-	-	-	-	-	-	15	3	1	-	-	-	-	2	-	-	-	-	-	5	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	15	-	3	1	-	-	-	-	-	-	-	-	5	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641936	Ives		Deoxycytidine kinase from calf ...	Bos taurus	Methods Enzymol.	51	337-345	1978	-	-	-	-	-	3	5	1	1	8	1	1	-	1	-	-	1	-	-	1	1	2	7	-	1	-	1	-	1	-	-	-	-	-	-	-	-	-	-	-	-	3	-	5	-	1	1	8	1	1	-	-	-	1	-	1	1	2	7	-	1	-	1	-	1	-	-	-	-	-	-	-	-	-
641945	Baxter		A general method for purificat ...	Bos taurus, Homo sapiens, Sus scrofa	Biochem. J.	173	1005-1008	1978	-	-	-	-	-	-	-	-	3	-	-	-	-	4	-	-	3	-	-	8	-	-	3	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	-	-	-	3	-	8	-	-	3	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-
641950	Deibler		Deoxynucleoside kinases from L ...	Lactobacillus acidophilus	J. Biol. Chem.	252	8240-8244	1977	-	-	-	-	-	-	9	1	-	1	-	-	-	1	-	-	-	11	-	-	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	9	-	1	-	1	-	-	-	-	-	-	-	-	-	-	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641933	Meyers		Purification of deoxycytidine ...	Mus musculus	Arch. Biochem. Biophys.	177	10-15	1976	1	-	-	-	-	1	-	2	1	1	-	-	-	1	-	-	1	-	-	2	2	-	4	-	1	-	-	2	-	-	-	-	-	-	-	1	-	-	-	-	-	1	-	-	-	2	1	1	-	-	-	-	-	1	-	2	2	-	4	-	1	-	-	2	-	-	-	-	-	-	-	-	-	-
641935	Krenitsky		Deoxycytidine kinase from calf ...	Bos taurus	J. Biol. Chem.	251	4055-4061	1976	-	-	-	-	-	-	6	3	-	1	-	-	-	1	-	-	-	-	-	1	-	-	11	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	6	-	3	-	1	-	-	-	-	-	-	-	1	-	-	11	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-
641948	Coleman		Deoxycytidine kinase: properti ...	Homo sapiens	Blood	46	791-803	1975	-	-	-	-	-	-	3	2	-	-	1	-	-	2	-	-	1	-	-	2	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	2	-	-	1	-	-	-	-	1	-	2	-	-	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641949	Leung		Mitochondrial and herpesvirus- ...	Aotus trivirgatus, Gallus gallus, Mus musculus	J. Virol.	16	486-497	1975	-	-	-	-	-	-	-	-	9	-	-	-	-	3	-	-	-	-	-	3	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	9	-	-	-	-	-	-	-	-	3	-	-	3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
677714	Wachsman		Demonstration of a deoxycytidi ...	Bacillus megaterium, Bacillus megaterium KM	Appl. Microbiol.	25	506-508	1973	-	-	-	-	-	-	1	-	-	-	-	-	-	3	-	-	-	-	-	-	-	-	7	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	7	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
641934	Kozai		Metabolism in deoxyribonucleot ...	Bos taurus	J. Biochem.	71	485-496	1972	-	-	-	-	-	-	21	3	1	5	-	-	-	1	-	-	1	-	-	1	1	-	13	-	1	-	-	-	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	21	-	3	1	5	-	-	-	-	-	1	-	1	1	-	13	-	1	-	-	-	1	1	-	-	-	-	-	-	-	-
641931	Durham		Deoxycytidine kinase. II. Puri ...	Bos taurus	J. Biol. Chem.	245	2276-2284	1970	2	-	-	-	-	1	22	-	-	10	1	-	-	1	-	-	1	-	-	1	1	2	9	-	1	-	2	-	1	-	3	-	-	-	-	2	-	-	-	-	-	1	-	22	-	-	-	10	1	-	-	-	-	1	-	1	1	2	9	-	1	-	2	-	1	-	3	-	-	-	-	-	-	-
641932	Ives		Deoxycytidine kinase. 3. Kinet ...	Bos taurus	J. Biol. Chem.	245	2285-2294	1970	-	-	-	-	-	-	3	-	-	1	-	-	-	1	-	-	-	-	-	1	-	-	4	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3	-	-	-	1	-	-	-	-	-	-	-	1	-	-	4	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-
641929	Kessel		Properties of deoxycytidine ki ...	Mus musculus	J. Biol. Chem.	243	4739-4744	1968	-	-	-	-	-	2	16	1	1	6	1	-	-	1	-	-	1	-	-	1	1	3	6	-	1	1	2	-	1	1	-	-	-	-	-	-	-	-	-	-	-	2	-	16	-	1	1	6	1	-	-	-	-	1	-	1	1	3	6	-	1	1	2	-	1	1	-	-	-	-	-	-	-	-
641930	Momparler		Mammalian deoxynucleoside kina ...	Bos taurus	J. Biol. Chem.	243	4298-4304	1968	1	-	-	-	-	-	8	5	1	3	-	-	-	1	-	-	1	-	-	1	1	-	7	-	1	-	-	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	-	8	-	5	1	3	-	-	-	-	-	1	-	1	1	-	7	-	1	-	-	-	-	-	-	-	-	-	-	-	-	-