Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors

Lv, P.C.; Wang, K.R.; Yang, Y.; Mao, W.J.; Chen, J.; Xiong, J.; Zhu, H.L.; Bioorg. Med. Chem. Lett. 19, 6750-6754 (2009)

 show all sequences of 2.3.1.180

Data extracted from this reference:

Application
Application Commentary Organism
drug development FabH is a particularly attractive target for design of antibacterial agents since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram positive and negative bacteria Escherichia coli
Inhibitors
Inhibitors Commentary Organism Structure
2,4-dibromo-6-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
 Escherichia coli
2,4-dibromo-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
2,4-dibromo-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
2,4-dichloro-6-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
 Escherichia coli
2,4-dichloro-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
2,4-dichloro-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-(3,4-dichlorophenyl)-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-(4-chlorophenyl)-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-4-(3,4-dichlorophenyl)-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
 Escherichia coli
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-(4-chlorophenyl)-2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-(4-chlorophenyl)-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-(4-chlorophenyl)-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-(4-chlorophenyl)-2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-bromo-2-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
 Escherichia coli
4-bromo-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
4-bromo-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
4-chloro-2-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
 Escherichia coli
4-chloro-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
4-chloro-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
additional information inhibitor design and synthesis, analysis of inhibitory potencies against FabH and antibacterial activities, overview Escherichia coli
-
Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Escherichia coli
-
 gene fabH
-
IC50 Value
IC50 Value IC50 Value Maximum Commentary Organism Inhibitor Structure
0.0036
-
-
 Escherichia coli 2,4-dibromo-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0068
-
-
 Escherichia coli 4-bromo-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0117
-
-
 Escherichia coli 4-chloro-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0165
-
-
 Escherichia coli 2,4-dichloro-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0396
-
-
 Escherichia coli 4-chloro-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0434
-
-
 Escherichia coli 4-bromo-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0576
-
-
 Escherichia coli 2,4-dichloro-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0784
-
-
 Escherichia coli 2,4-dibromo-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
Application (protein specific)
Application Commentary Organism
drug development FabH is a particularly attractive target for design of antibacterial agents since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram positive and negative bacteria Escherichia coli
IC50 Value (protein specific)
IC50 Value IC50 Value Maximum Commentary Organism Inhibitor Structure
0.0036
-
-
 Escherichia coli 2,4-dibromo-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0068
-
-
 Escherichia coli 4-bromo-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0117
-
-
 Escherichia coli 4-chloro-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0165
-
-
 Escherichia coli 2,4-dichloro-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0396
-
-
 Escherichia coli 4-chloro-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0434
-
-
 Escherichia coli 4-bromo-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0576
-
-
 Escherichia coli 2,4-dichloro-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
0.0784
-
-
 Escherichia coli 2,4-dibromo-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
Inhibitors (protein specific)
Inhibitors Commentary Organism Structure
2,4-dibromo-6-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
 Escherichia coli
2,4-dibromo-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
2,4-dibromo-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
2,4-dichloro-6-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
 Escherichia coli
2,4-dichloro-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
2,4-dichloro-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-(3,4-dichlorophenyl)-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-(4-chlorophenyl)-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-4-(3,4-dichlorophenyl)-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
 Escherichia coli
2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
 Escherichia coli
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-(4-chlorophenyl)-2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-(4-chlorophenyl)-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-(4-chlorophenyl)-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-(4-chlorophenyl)-2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-1,3-thiazole
-
 Escherichia coli
4-bromo-2-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
 Escherichia coli
4-bromo-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
4-bromo-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
4-chloro-2-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
 Escherichia coli
4-chloro-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
4-chloro-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
 Escherichia coli
additional information inhibitor design and synthesis, analysis of inhibitory potencies against FabH and antibacterial activities, overview Escherichia coli
-
General Information
General Information Commentary Organism
physiological function FabH is central to the initiation of fatty acid biosynthesis Escherichia coli
General Information (protein specific)
General Information Commentary Organism
physiological function FabH is central to the initiation of fatty acid biosynthesis Escherichia coli

See also following references to EC number 2.3.1.180 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
701521HuynhCloning, expression, crystalli ...Xanthomonas oryzae pv. oryzaeActa Crystallogr. Sect. F65460-4622009--11---------5--1-----12-------------1-1-------------1----12---------11---
702531MatsumotoProduction of short-chain-leng ...Arabidopsis thaliana, Escherichia coliBiomacromolecules10686-6902009--1-2---2----7-----1-----------------1--2-----2--------1-------------11---
702601LvDesign, synthesis and biologic ...Escherichia coliBioorg. Med. Chem. Lett.196750-67542009-1----28------3--------------------8-1-----828-------------------------11---
702634LeeNovel E. coli beta-ketoacyl-ac ...Escherichia coli K-12Bioorg. Med. Chem.171506-15132009--1---4------3--------------1--------1-----4--------------------1----11---
702656LeeAntimicrobial natural products ...Escherichia coli K-12Bioorg. Med. Chem.175408-54132009--1---3----1-2--------1-----1--------1-----3-----1--------1-----1---------
702661LiSynthesis of C(7) modified chr ...Escherichia coliBioorg. Med. Chem.176264-62692009-11---16----2-3--1-----2-----1-------11-----16-----2---1----2-----1---------
703762SinghFabH selectivity for anteiso b ...Listeria monocytogenesFEMS Microbiol. Lett.301188-1922009-------7---6-4--------8-1--7-----------------7---6--------8-1--7-----11-77
704622Veyron-ChurletThe Mycobacterium tuberculosis ...Mycobacterium tuberculosisJ. Biol. Chem.2846414-64242009--112------2-3-11-----3-1---2--------1-12--------2--11----3-1---2----11---
705055LeeTargeting the fatty acid biosy ...Plasmodium falciparumJ. Med. Chem.52952-9632009-1----43----1-3--------1-----------43-1-----4343-----1--------1----------11---
706427Al-BalasIdentification of 2-aminothiaz ...Mycobacterium tuberculosisPLoS ONE4e56172009-1----11------4--------------------6-1-----611------------------------------
706592WenFunctional expression of Franc ...Francisella tularensis subsp. holarcticaProtein Expr. Purif.6583-912009--1---13----1-1--1-----1-1---1-----15--1----1513-----1---1----1-1---1----11---
685507SachdevaProbing reactivity and substra ...Mycobacterium tuberculosisBioorg. Chem.3685-902008---1---------2-------------------------1----------------------------------
686049SachdevaSeparate entrance and exit por ...Mycobacterium tuberculosisChem. Biol.15402-4122008---1---------3---1---------------------1----------------------------------
688834SachdevaMycobacterium tuberculosis bet ...Mycobacterium tuberculosisMethods Mol. Med.142205-2132008-------------3------1-----------------------------------1-----------------
688880CastilloBacterial beta-ketoacyl-acyl c ...Enterococcus faecium, Escherichia coli, Haemophilus influenzae, Mycobacterium tuberculosis, Neisseria meningitidis, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenesMini Rev. Med. Chem.836-452008------33------11--------------------23-------2333------------------------------
690169LiMolecular cloning and expressi ...Jatropha curcasTree Physiol.28921-9272008--1----------3-----2-----------------1-----------------2------------------
703548SinghQSAR studies on benzoylaminobe ...Enterococcus faecalis, Escherichia coli, Neisseria meningitidis, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenesEur. J. Med. Chem.431071-10802008------276----6-13--------6--------------------276-----6--------6---------------
672628AlhamadshehSynthesis and biological evalu ...Escherichia coli, Mycobacterium tuberculosis, Plasmodium falciparumBioorg. Med. Chem. Lett.17879-8832007------46------7--------2-----------47-------4746--------------2---------------
676903WangDiscovery of platencin, a dual ...Staphylococcus aureusProc. Natl. Acad. Sci. USA1047612-76162007------2------1--------------------1-------12------------------------------
685898Jeong-Homology modeling and docking ...Enterococcus faecalisBull. Korean Chem. Soc.281335-13402007------1------1-----------------------------1------------------------------
686047AlhamadshehAlkyl-CoA disulfides as inhibi ...Escherichia coli, Mycobacterium tuberculosisChem. Biol.14513-5242007---1--5------5--------2-----------3----1--35--------------2---------------
688033AshekHQSAR study of beta-ketoacyl-a ...Enterococcus faecalisJ. Enzyme Inhib. Med. Chem.227-142007------36------2-----------------------------36------------------------------
659493BrownProbing the mechanism of the M ...Mycobacterium tuberculosisJ. Biol. Chem.28032539-325472005--119------1-4--11----3-1---2--------1-19--------1---1----3-1---2---------
659724MusayevCrystal structure of a substra ...Mycobacterium tuberculosisJ. Mol. Biol.3461313-13212005---1-------1-3---1----31---------------1---------1--------31--------------
660466QiuCrystal structure and substrat ...Staphylococcus aureusProtein Sci.142087-20942005--11---5---1-5--11--9-1111--81--------1-1-----5---1---1--9-1111--81---------
665387LiAlteration of the fatty acid p ...Streptomyces coelicolorJ. Bacteriol.1873795-37992005----1------2-6--------4-----------------1--------2--------4---------------
665975NieStructure-based design, synthe ...Enterococcus faecalisJ. Med. Chem.481596-16092005-1-1--59----1-2--------2-----1-----46-1--1--4659-----1--------2-----1---------
663647He1,2-dithiole-3-ones as potent ...Escherichia coli, Staphylococcus aureusAntimicrob. Agents Chemother.483093-31022004------8----2-4--------4-2---2-----2-------28-----2--------4-2---2---------
663702NomuraCoexpression of genetically en ...Escherichia coliAppl. Environ. Microbiol.70999-10072004--1-19------1-4--------1--------------1--19--------1--------1---------------
659294Laibeta-Ketoacyl-acyl carrier pro ...Escherichia coli, Lactococcus lactis ssp. lactisJ. Biol. Chem.27851494-515032003----2---1--3-6------1-4-1---1-----------2-----1--3------1-4-1---1---------
666668Jonesbeta-Ketoacyl-acyl carrier pro ...Pisum sativumPlanta216752-7612003--1---12--11-6--11-1--211---1-----1--1----11-2--11---1-1--211---1---------
486946HePurification, characterization ...Staphylococcus aureusAntimicrob. Agents Chemother.461310-13182002-21---53--11-6-11-----411--31-----3-21----35-3--11--11----411--31---------
664003FlorovaEnzymes involved in fatty acid ...Streptomyces glaucescensBiochemistry4110462-104712002-----------2-1--------3--------------------------2--------3---------------
486938SmirnovaEngineered fatty acid biosynth ...Streptomyces glaucescensJ. Bacteriol.1832335-23422001--1-3------1-5--1-----2--------------1--3--------1---1----2---------------
486939KhandekarIdentification, substrate spec ...Streptococcus pneumoniaeJ. Biol. Chem.27630024-300302001-11---32---1-6--11--2-61----1-----3-11----33-2---1---1--2-61----1---------
663684KiatpapanMolecular characterization of ...Lactobacillus plantarumAppl. Environ. Microbiol.67426-4332001--1--------1-7--------1--------------1-----------1--------1---------------
665365Revillbeta-Ketoacyl acyl carrier pro ...Streptomyces coelicolorJ. Bacteriol.1833526-353020011-1--------2-4--------3------------1-1-----------2--------3---------------
665477ScarsdaleCrystal structure of the Mycob ...Mycobacterium tuberculosisJ. Biol. Chem.27620516-205222001-1-1-------1-4--11----2-------------1--1---------1---1----2---------------
666011QiuRefined structures of beta-ket ...Escherichia coliJ. Mol. Biol.307341-3562001---1-------1-2---1----11---------------1---------1--------11--------------
666615DeheshOverexpression of 3-ketoacyl-a ...Brassica napus, Cuphea hookeriana, Nicotiana tabacum, Spinacia oleraceaPlant Physiol.1251103-11142001--3-3------7-10-----93-714---4----2---3--3--------7-----93-714---4--2------
486937Choibeta-ketoacyl-acyl carrier pro ...Bacillus subtilisJ. Bacteriol.182365-3702000--1----------4------5-11-1---1--------1------------------5-11-1---1---------
663471JansonCrystallization of Escherichia ...Escherichia coliActa Crystallogr. Sect. D56747-7482000-1-1-------1-3--------1-------------1--1---------1--------1---------------
663822KhandekarExpression, purification, and ...Escherichia coliBiochem. Biophys. Res. Commun.270100-1072000--11------11-3--1---1-221-2-1----1---1-1--------11---1--1-221-2-1--1------
663922AbbadiReaction mechanism of recombin ...Cuphea wrightiiBiochem. J.345153-1602000--1-9--3---1-5--11-15-1-1---1--------1--9----3---1---1-15-1-1---1---------
665474ChoiIdentification and substrate s ...Mycobacterium tuberculosisJ. Biol. Chem.27528201-282072000--1---7----1-6--11--2-911---1--------1-----7-----1---1--2-911---1---------
666354HwangMolecular cloning and function ...Perilla frutescensMol. Cells10375-3812000--1--------1-5-----2--1-1---1----2---2-----------2-----4--2-2---2--2------
666596AbbadiKnockout of the regulatory sit ...Cuphea wrightiiPlant J.241-92000--1-3-1----2-7--1---1-3-1---1--------2--6--2-----2---2--2-4-2---2---------
666950DaviesThe 1.8 A crystal structure an ...Escherichia coliStructure8185-1952000--113-1----1-3--11----321---1--------1-13--1-----1---1----321---1---------
486934BaoPurification and properties of ...Streptomyces peucetiusBiochemistry389752-97571999--1-------11-4--1-----311---1--------1----------11---1----311---1---------
665472QiuCrystal structure of beta-keto ...Escherichia coliJ. Biol. Chem.27436465-364711999-1-1-------1-2---1----11------------1--1---------1--------11--------------
486933HanCharacterization of beta-ketoa ...Streptomyces glaucescensJ. Bacteriol.1804481-44861998-11---14--14-5--1-----511---1-------11-----1-4--14---1----511---1---------
665468HeathInhibition of beta-ketoacyl-ac ...Escherichia coliJ. Biol. Chem.27110996-110001996--1---22---1-2--1---1-5-1---1---1----1-----212---1---1--1-5-1---1---------
666666Brueck-In-vitro evidence for feed-bac ...Cuphea lanceolataPlanta198271-2781996------51---1-1-----1--2-1-------1-2-------2511---1-----1--2-1-------------
486932VerwoertModification of Brassica napus ...Escherichia coliPlant Mol. Biol.27875-8861995--1-1--2-----4-----21---1---1--------1--1----2---------21---1---1---------
486931CloughPurification and characterizat ...Spinacia oleraceaJ. Biol. Chem.26720992-209981992-----12---11-3--1--111211---1--1------1--1-2----11---1-111211---1---------
665464TsayIsolation and characterization ...Escherichia coli K-12J. Biol. Chem.2676807-68141992--1--------1-2--11--2-211---1----1---1-----------1---1--2-211---1--1------