The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling

Dacwag, C.S.; Ohkawa, Y.; Pal, S.; Sif, S.; Imbalzano, A.N.; Mol. Cell. Biol. 27, 384-394 (2007)

 show all sequences of 2.1.1.125

Data extracted from this reference:

Localization
Localization Commentary Organism GeneOntology No. Textmining
Natural Substrates/ Products (Substrates)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
histone H3 + S-adenosyl-L-methionine Mus musculus PRMT5 symmetrically dimethylates histone H3 at arginine 8 ?
-
-
 ?
histone H4 + S-adenosyl-L-methionine Mus musculus PRMT5 symmetrically dimethylates histone H4 ?
-
-
 ?
protein-L-arginine + S-adenosyl-L-methionine Mus musculus
-
 Nomega-methyl-L-arginine-protein + Nomega,Nomega-dimethyl-L-arginine-protein + S-adenosyl-L-homocysteine
-
-
 ?
Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Mus musculus
-
-
-
Purification (Commentary)
Commentary Organism
cell extracts are generated Mus musculus
Source Tissue
Source Tissue Commentary Organism Textmining
myofibroblast myofiber Mus musculus
-
NIH-3T3 cell
-
 Mus musculus
-
satellite cell
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-
Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
histone H3 + S-adenosyl-L-methionine PRMT5 symmetrically dimethylates histone H3 at arginine 8 688965 Mus musculus ?
-
-
-
 ?
histone H4 + S-adenosyl-L-methionine PRMT5 symmetrically dimethylates histone H4 688965 Mus musculus ?
-
-
-
 ?
protein-L-arginine + S-adenosyl-L-methionine
-
 688965 Mus musculus Nomega-methyl-L-arginine-protein + Nomega,Nomega-dimethyl-L-arginine-protein + S-adenosyl-L-homocysteine
-
-
-
 ?
Cofactor
Cofactor Commentary Organism Structure
S-adenosyl-L-methionine
-
 Mus musculus
Cofactor (protein specific)
Cofactor Commentary Organism Structure
S-adenosyl-L-methionine
-
 Mus musculus
Localization (protein specific)
Localization Commentary Organism GeneOntology No. Textmining
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
histone H3 + S-adenosyl-L-methionine Mus musculus PRMT5 symmetrically dimethylates histone H3 at arginine 8 ?
-
-
 ?
histone H4 + S-adenosyl-L-methionine Mus musculus PRMT5 symmetrically dimethylates histone H4 ?
-
-
 ?
protein-L-arginine + S-adenosyl-L-methionine Mus musculus
-
 Nomega-methyl-L-arginine-protein + Nomega,Nomega-dimethyl-L-arginine-protein + S-adenosyl-L-homocysteine
-
-
 ?
Purification (Commentary) (protein specific)
Commentary Organism
cell extracts are generated Mus musculus
Source Tissue (protein specific)
Source Tissue Commentary Organism Textmining
myofibroblast myofiber Mus musculus
-
NIH-3T3 cell
-
 Mus musculus
-
satellite cell
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
histone H3 + S-adenosyl-L-methionine PRMT5 symmetrically dimethylates histone H3 at arginine 8 688965 Mus musculus ?
-
-
-
 ?
histone H4 + S-adenosyl-L-methionine PRMT5 symmetrically dimethylates histone H4 688965 Mus musculus ?
-
-
-
 ?
protein-L-arginine + S-adenosyl-L-methionine
-
 688965 Mus musculus Nomega-methyl-L-arginine-protein + Nomega,Nomega-dimethyl-L-arginine-protein + S-adenosyl-L-homocysteine
-
-
-
 ?

See also following references to EC number 2.1.1.125 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
718463DillonNovel inhibitors for PRMT1 dis ...Homo sapiensACS Chem. Biol.71198-12042012--1-1-6------2--1-----1--------------1--1--6---------1----1---------------
718797GuProtein arginine methyltransfe ...Homo sapiensBiochem. J.446235-2412012-1-----------4-----13----------------1------------------13-------------22---
718940KoelbelPeptide backbone conformation ...Rattus norvegicusBiochemistry515463-54752012-------16-----2--------151---16-----------------16------------151---16--------1616
719469ZhongIdentification and characteriz ...Homo sapiensFEBS J.279316-3352012-1------1----5-----9--41------------4---------4--------32--44--------92812--
720039KarkhanisProtein arginine methyltransfe ...Homo sapiensJ. Biol. Chem.28729801-298142012-------------1-----2--2--------------------------------2--2----------22---
720047CampbellProtein arginine methyltransfe ...Homo sapiensJ. Biol. Chem.2875806-58182012-------------3-----1--21-------------------------------1--21---------11---
720050ObianyoKinetic mechanism of protein a ...Homo sapiensJ. Biol. Chem.2876062-60712012--1---74-----2--1-----8----4---------1-----7-4-------1----8----4--------1212
720059Zurita-LopezHuman protein arginine methylt ...Homo sapiensJ. Biol. Chem.2877859-787020121-1----------4--1-----121-----------1-1---------------1----121--------------
720094LeeProtein arginine methylation o ...Homo sapiensJ. Cell. Biochem.1132721-27282012-------------2-----1--1--------------------------------1--1---------------
720960NiuThe enzymatic activity of Arab ...Arabidopsis thalianaProtein Cell3450-4592012--13-54--------3--------2--------------13--54-----------------2----------2626---
718786SackStructural basis for CARM1 inh ...Rattus norvegicusBiochem. J.436331-3392011--11--3------2--1-----1-----------3--1-1--33---------1----1---------------
718910FengA transient kinetic analysis o ...Rattus norvegicusBiochemistry507033-70442011--1----6-----2--1-----51---6---------1-------6-------1----51---6--------206206
718987HandrkovaTyrosine 87 is vital for the a ...Homo sapiensBiochim. Biophys. Acta1814277-2822011----3---3--1-6-9---1--1-----------------3-----3--1--9--1--1---------------
719656WangLabeling substrates of protein ...Homo sapiensJ. Am. Chem. Soc.1337648-76512011----11--------3--------4-----------------11-----------------4---------------
719953GuiInvestigation of the molecular ...Rattus norvegicusJ. Biol. Chem.28629118-291262011--114--4-----2--1-----5----4---------1-14----4-------1----5----4--------44
719990WilczekProtein arginine methyltransfe ...Xenopus laevisJ. Biol. Chem.28642221-4223120112-2----------4--2--3--6------------2-2---------------2-3--6---------------
720190ChengNovel 3,5-bis(bromohydroxybenz ...Homo sapiensJ. Med. Chem.544928-49322011------13------2-----1--1-----------10-------1013-----------1--1---------------
720433BickerA combinatorial approach to ch ...Homo sapiensMol. Biosyst.748-512011------33---2-2--------5----3------6-------63-3---2--------5----3-----11-33
704652KimEnzymatic activity is required ...Mus musculusJ. Biol. Chem.2851147-11522010--1-1---83----3-----4----83---1--------1--1-----83--------4----83---1----8383---
707387YuProtein arginine methyltransfe ...Escherichia coliBiochem. Biophys. Res. Commun.391322-3282010--354----------3--------1--------------354--------------------1---------------
709093RenMethylation of ribosomal prote ...Homo sapiensJ. Biol. Chem.28512695-127052010--1----------2--------1--------------1--------------------1---------------
709115ChangProtein-arginine methyltransfe ...Rattus norvegicusJ. Biol. Chem.28520595-206062010--1----------3-----------------------1------------------------------------
709944van DijkFriend of Prmt1, a novel chrom ...Mus musculusMol. Cell. Biol.30260-2722010--1----------3-----1--1--------------1-----------------1--1---------------
720581HarrisonProtein arginine methyltransfe ...Homo sapiensNucleic Acids Res.382201-22162010--1-----1----2-----1--3--------------1--------1--------1--3----------22---
720902DengArginine methylation mediated ...Arabidopsis thalianaProc. Natl. Acad. Sci. USA10719114-191192010-------------3--------5-----------------------------------5----------1313---
702131FanCharacterization of PRMT1 from ...Plasmodium falciparumBiochem. J.421107-1182009--8---11816--4-3--------11-8--81--1--8--81---811-816--4--------11-8--81-------88
702134LakowskiKinetic analysis of human prot ...Homo sapiens, no activity in Escherichia coli, no activity in Escherichia coli DH5alphaBiochem. J.421253-2612009--1-1--5---2-6---1--1-6-9--51--1-----22-1----6---2------2-6-10--62---1121910
703227HeinkeVirtual screening and biologic ...Homo sapiensChemMedChem469-772009-1----14------2--------1-1---1-----9-1-----914--------------1-1---1---------
704575CesaroThe Kruppel-like zinc finger p ...Homo sapiensJ. Biol. Chem.28432321-3233020091-1-----1--2-3--------3--------1---1-11-------1--2--------3----------11---
704604FengBiochemical control of CARM1 e ...Homo sapiensJ. Biol. Chem.28436167-361742009----4---2--4-2-1---2--5--------1------1-4-----2--4--1--2--5----------11---
704639XieEpigenetic regulation of trans ...Homo sapiensJ. Biol. Chem.2849199-92052009----1---2--3-2-----3--6--------1------1-1-----2--3-----3--6----------11---
704703SelviIdentification of a novel inhi ...Homo sapiensJ. Biol. Chem.2857143-71522009------1-1--2-2-----1--3--------1--1---1---11--1--2-----1--3----------11---
704794MajumderMethylation of histone H3 and ...Homo sapiensJ. Cell. Biochem.109553-5632009--1--------3-1--------5--------1-----11----------3--------5----------11---
705690DacwagDistinct protein arginine meth ...Mus musculus, Mus musculus BL6Mol. Cell. Biol.291909-19212009----1---1--1-3-----4--3--------1------1-1-----1--1-----4--3----------8383---
705701MatsudaNovel functions of protein arg ...Xenopus laevisMol. Cell. Biol.29745-7572009--2-----2--2-3-----8--4--------2-----22-------2--2-----8--4---------2222--
705870ZhaoPRMT5-mediated methylation of ...Homo sapiensNat. Struct. Mol. Biol.16304-3112009--1-1---2--2-3-----1--3--------1-----11-1-----2--2-----1--3----------11---
706095NicholsonThe physiological and pathophy ...Homo sapiensPharmacol. Res.60466-4742009-------------3-------------------------------------------------------11---
706414YangCaenorhabditis elegans protein ...Caenorhabditis elegansPLoS Genet.FEHLT00002009--8-8---8--16-4--------24--------8-----88-8-----8--16--------24----------88---
707357FengInhibitory study of protein ar ...Rattus norvegicusBiochem. Biophys. Res. Commun.379567-5722009-141---12-----2--------2----2----2---141-----122------------2----2----------
708583HerrmannNucleo-cytoplasmic shuttling o ...Homo sapiensGenes Cells14309-3172009-11-1---2----3----------------------11--1-----2---------------------------
709978IgarashiGANP suppresses the arginine m ...Homo sapiensMol. Immunol.461031-10412009-------------3-----1-----------------------------------1------------------
710117KousakaThe distribution and character ...Mus musculusNeuroscience1631146-11572009--------1----3-1---8--------------------------1-----1--8------------------
710339YangCaenorhabditis elegans protein ...Caenorhabditis elegansPLOS Genet.5e10005142009-------------4------------------------------------------------------------
684928SayeghHsl7 is a substrate-specific t ...Saccharomyces cerevisiaeBiochem. Biophys. Res. Commun.372811-8152008--194-388---194--3-3--------5-194---1--194-----194194-388-----194--3--------5-194---1---------
685191ObianyoKinetic mechanism of protein a ...Homo sapiensBiochemistry4710420-104272008-11---71---1-3--11-1--5-9--41--11---111----711---1---1-1--5-9--41---------
686397LacroixThe histone-binding protein CO ...Homo sapiensEMBO Rep.9452-45820082-1-----2--2-2--------3--------1---2-11-------2--2--------3---------------
686759VerbiestProtein arginine (N)-methyl tr ...Cricetulus griseus, Homo sapiensFEBS Lett.5821483-14892008-44---4---6--3--4--7--4--------4----444----4----6----4-7--4---------------
688274MaiEpigenetic multiple ligands: m ...Emericella nidulans, Homo sapiensJ. Med. Chem.512279-22902008--23---207----24-3--23--1--24-24---2--24-----2324----207-----24---23-1--24-24---2---------
688407HassaProtein arginine methyltransfe ...Homo sapiensJ. Mol. Biol.377668-6782008--1-1------1-4-----2--2--------1-----11-1--------1-----2--2---------------
688971HouThe LIM protein AJUBA recruits ...Homo sapiensMol. Cell. Biol.283198-32072008--1-3------1-2--------1--------1-----11-3--------1--------1---------------
688977WangProtein arginine methyltransfe ...Homo sapiensMol. Cell. Biol.286262-62772008-1--1-1-2--3-3-----2--3--------1----1-1-1--1--2--3-----2--3---------9229--
689256KleinschmidtThe protein arginine methyltra ...Homo sapiensNucleic Acids Res.363202-321320081-1-----1--1-2--1--1--1------------1-1--------1--1---1-1--1---------9--9--
689951PahlichIdentification of proteins int ...Homo sapiensProteins721125-11372008--1----21--3-3--1--2--1321------1-----11------21--3---1-2--1321-------------
702248WooderchakSubstrate profiling of PRMT1 r ...Homo sapiensBiochemistry479456-94662008-------3---1-2---9----5--------1------1------3---1--------5-------------2727
704441IbergArginine methylation of the hi ...Homo sapiens, Mus musculusJ. Biol. Chem.2833006-30102008--2-2------4-3-----1--6--------2-----22-2--------4-----1--6---------------
706494SchmitzHistone arginine methylation i ...Arabidopsis thalianaProc. Natl. Acad. Sci. USA105411-4162008--1-1---2--3-3-----1--4--------1-----11-1-----2--3-----1--4----------11---
676004LeeSurface-scanning mutational an ...Rattus norvegicusMol. Endocrinol.211381-13932007-11-108--------2--1-----3341---1--1----111-102------------1----3341---1---------
685111OsborneProtein arginine methyltransfe ...Homo sapiens, Rattus norvegicusBiochemistry4613370-133812007-22-41-1023--42--4--2-----24-10--232--2--205-222-41-20510-23--42----2----24-10--232---------
685877TanedaSpecific regional distribution ...Mus musculusBrain Res.11551-92007-------------3-----27--1--------1------1----------------27--1---------------
685939TengAS1411 alters the localization ...Homo sapiensCancer Res.6710491-1050020071-------2----3-----1--2--------1---1--1-------2--------1--2---------------
686395NiuRegulation of flowering time b ...Arabidopsis thaliana, Brassica oleraceaEMBO Rep.81190-11952007----------6--6--3-----23-------1------1---------6----3----23--------------
686464PasternackEvolutionarily divergent type ...Trypanosoma bruceiEukaryot. Cell61665-16812007--8-----8-16--6--8-----16-8---1--8-----88-------8-16----8----16-8---1---------
687472HungCharacterization of protein ar ...Bos taurusJ. Biochem. Mol. Biol.40617-6242007--------1-8--3--1--18-1-4---1--1------1-------1-8----1-18-1-4---1---------
687632GouletAlternative splicing yields pr ...Homo sapiensJ. Biol. Chem.28233009-330212007-11-1---2-71-3--1--8--9-1---1--1----111-1-----2-71---1-8--9-1---1---------
687657SayeghRegulation of protein arginine ...Homo sapiensJ. Biol. Chem.28236444-364532007--1-1---3----3-21--6--3-1---1--1-----11-1-----3-----21-6--3-1---1---------
688680MeyerPRMT2, a member of the protein ...Homo sapiensJ. Steroid Biochem. Mol. Biol.1071-142007--1-----2--1-3--1--3--1--------1-----11-------2--1---1-3--1---------------
688965DacwagThe protein arginine methyltra ...Mus musculusMol. Cell. Biol.27384-3942007--------1--3-2--1--4--3--------1------1-------1--3---1-4--3---------------
689581PeiMutations in the type II prote ...Arabidopsis thaliana, Brassica oleraceaPlant Physiol.1441913-19232007--13-------23-8--15-----8-15---2--15-----1315---------23---15----8-15---2---------
671765KimCharacterization of a novel WH ...Homo sapiens, Mus musculusBiochem. Biophys. Res. Commun.345318-3232006-21----------5--1--1--2-------------21---------------1-1--2---------------
672364GrosCharacterization of prmt7alpha ...Cricetulus longicaudatus, Homo sapiens, Mus musculusBiochim. Biophys. Acta17601646-16562006--1-1---87-5--7-----7--2884---2--------1--1-----87-5------7--2884---2---------
676742Jelinic-The testis-specific factor CTC ...Mus musculusPLoS Biol.41910-192220061-1--------2-1-----2--31-----------1-1-----------2-----2--31--------------
676744JelinicThe testis-specific factor CTC ...Mus musculusPLoS Biol.4e3552006111----------3-----3--2------------111-----------------3--2---------------
671706MansureCloning of a protein arginine ...Schistosoma mansoniBiochem. Biophys. Res. Commun.3351163-11722005-11-------1--3-----1--4-------------11----------1------1--4---------------
673853HuangMethylation of histone H4 by a ...Gallus gallusGenes Dev.191885-18932005-8--8---8----3-----8--8-------------8---8-----8--------8--8---------------
674490LeePRMT7, a new protein arginine ...Homo sapiensJ. Biol. Chem.2803656-36642005--1--------3-4--1-----6-9---1--------1-----------3---1----6-9---1---------
674500HerrmannDynamics of human protein argi ...Homo sapiensJ. Biol. Chem.28038005-380102005-11---1-2----3----------------------11-----1--2---------------------------
659344MirandaPRMT7 is a member of the prote ...Homo sapiensJ. Biol. Chem.27922902-229072004--1----------4--11----2--------------1---------------1----2---------------
703144AnOrdered cooperative functions ...Homo sapiensCell117735-74820041-1---1-1--3-1--1-----3--------1---1-11----1--1--3---1----3----------99---
660500WangMethylation of histone H4 at a ...Homo sapiensScience293853-8562001------1-1-91-1--1--1--21-------------------1--1-91---1-1--21--------------
657710Han-S-Adenosylmethionine:protein-a ...Bos taurusBiochem. Arch.1545-571999------5118---1--1--11-54--4-1---8----------58118-----1-11-54--4-1---------
15210RajpurohitEnzymatic methylation of recom ...Bos taurusJ. Biol. Chem.2691075-10821994------244----3--1--1--2--------------------2-44------1-1--2---------------
15214SyedComparative studies on S-adeno ...Bos taurusJ. Protein Chem.12603-6121993-------------1-----1--1--------------------------------1--1---------------
15216PaikHuman placental protein methyl ...Homo sapiensInt. J. Biochem.23939-9451991------11-----1--1--1--1--------------------1-1-------1-1--1---------------
15213ParkStudies on protein methyltrans ...Homo sapiensJ. Mol. Neurosci.1151-1571989-------------1-----1--1--------------------------------1--1---------------
15220Gosh-Erratum: Purification and mole ...Bos taurusJ. Biol. Chem.26453131989-------------1-----1-----------------------------------1------------------
15211GoshPurification and molecular ide ...Bos taurusJ. Biol. Chem.26319024-190331988-----442--4--1--1--14-24--8--------------4-4-2--4----1-14-24--8-----------
15212ParkMyelin basic protein inhibits ...Bos taurusBiochim. Biophys. Acta87430-361986------1------1--1--14----------------------1---------1-14-----------------
15219DisaSite specificity of histone H4 ...Triticum aestivumBiochemistry252443-24481986-------------1--------4-----------------------------------4---------------
15215TuckS-Adenosylmethionine:protein ( ...Triticum aestivumMethods Enzymol.106268-27419842-----92-----1--2--22-2-----1------2-------9-2-------2-22-2-----1---------
15217GuptaHistone-specific protein-argin ...Triticum aestivumJ. Biol. Chem.2579677-968319822-----104-----1-----2--4-----1------2-------10-4---------2--4-----1---------
15218LeeS-Adenosylmethionine:protein-a ...Bos taurusBiochemistry1678-851977------13-----1--14-1--3-----1--------------1-3-------1-1--3-----1---------