The interconversion of glutamic acid and proline

Strecker, H.J.; J. Biol. Chem. 235, 3218-3223 (1960)

 show all sequences of 1.5.1.12

Data extracted from this reference:

Inhibitors
Inhibitors Commentary Organism Structure
5-Aminopentanoate
-
 Bos taurus
ADP
-
 Bos taurus
AMP
-
 Bos taurus
ATP
-
 Bos taurus
CN-
-
 Bos taurus
Cu2+
-
 Bos taurus
additional information no inhibition: Ca2+, Mn2+, Mg2+, Ba2+, Pb2+, N-ethylmaleimide, o-phenanthroline Bos taurus
-
N-ethylmaleimide no inhibition Bos taurus
NH2OH
-
 Bos taurus
p-hydroxymercuribenzoate
-
 Bos taurus
Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Bos taurus
-
-
-
Source Tissue
Source Tissue Commentary Organism Textmining
liver
-
 Bos taurus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Commentary Organism
additional information
-
-
 Bos taurus
Storage Stability
Storage Stability Organism
-15°C, 50% loss of activity, 2 months Bos taurus
Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
1-pyrroline-5-carboxylate + NAD+ + H2O
-
 392056 Bos taurus L-glutamate + NADH
-
 392056 Bos taurus ir
DELTA1-pyrroline-3-hydroxy-5-carboxylate + NAD+ + H2O
-
 392056 Bos taurus 4-hydroxyglutamate + NADH
-
-
-
 ?
pH Optimum
pH Optimum Minimum pH Optimum Maximum Commentary Organism
8.5 8.6
-
 Bos taurus
pH Range
pH Minimum pH Maximum Commentary Organism
7.4 9.4
-
 Bos taurus
Cofactor
Cofactor Commentary Organism Structure
NAD+ preferentially Bos taurus
NADP+
-
 Bos taurus
Cofactor (protein specific)
Cofactor Commentary Organism Structure
NAD+ preferentially Bos taurus
NADP+
-
 Bos taurus
Inhibitors (protein specific)
Inhibitors Commentary Organism Structure
5-Aminopentanoate
-
 Bos taurus
ADP
-
 Bos taurus
AMP
-
 Bos taurus
ATP
-
 Bos taurus
CN-
-
 Bos taurus
Cu2+
-
 Bos taurus
additional information no inhibition: Ca2+, Mn2+, Mg2+, Ba2+, Pb2+, N-ethylmaleimide, o-phenanthroline Bos taurus
-
N-ethylmaleimide no inhibition Bos taurus
NH2OH
-
 Bos taurus
p-hydroxymercuribenzoate
-
 Bos taurus
Source Tissue (protein specific)
Source Tissue Commentary Organism Textmining
liver
-
 Bos taurus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Commentary Organism
additional information
-
-
 Bos taurus
Storage Stability (protein specific)
Storage Stability Organism
-15°C, 50% loss of activity, 2 months Bos taurus
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
1-pyrroline-5-carboxylate + NAD+ + H2O
-
 392056 Bos taurus L-glutamate + NADH
-
 392056 Bos taurus ir
DELTA1-pyrroline-3-hydroxy-5-carboxylate + NAD+ + H2O
-
 392056 Bos taurus 4-hydroxyglutamate + NADH
-
-
-
 ?
pH Optimum (protein specific)
pH Optimum Minimum pH Optimum Maximum Commentary Organism
8.5 8.6
-
 Bos taurus
pH Range (protein specific)
pH Minimum pH Maximum Commentary Organism
7.4 9.4
-
 Bos taurus

See also following references to EC number 1.5.1.12 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
698095GaoEvolutionary and expression st ...Oryza sativaGene43186-942009--1-----1-21-2-----1--1--------2-----24-------1-22-----2--2---------------
698936MillerUnraveling delta1-pyrroline-5- ...Arabidopsis thalianaJ. Biol. Chem.28426482-264922009----1---2----5--------------------------1-----2---------------------------
701646WuArginine metabolism and nutrit ...MammaliaAmino Acids37153-16820091-----1------1-----2---------------1-------1-----------2-------------11---
675774TizzanoIs rat LRRP Ba1-651 a Delta-1- ...Rattus norvegicusMed. Hypotheses68864-8672007-------------3------------------------------------------------------------
675402InagakiCrystal structure of Thermus t ...Thermus thermophilusJ. Mol. Biol.362490-5012006---1---3-----3--------31---31----------1-----3------------31---31---------
654887HaslettAssay and subcellular localiza ...Rattus norvegicusBiochim. Biophys. Acta167581-862004--------1--1-3--11-22-2-1---1--2------2-------1--1---1-22-2-1---1---------
392066DonaldProline oxidase, encoded by p5 ...Homo sapiensCancer Res.611810-18152001-------------1------------------------------------------------------------
392061Forlani-Expression of DELTA1-pyrroline ...Arthrospira platensis, Daucus carota, Nicotiana plumbaginifolia, Solanum glaucophyllum, Solanum lycopersicum, Solanum melongena, Solanum tuberosumPhysiol. Plant.11022-272000-----------2-7---1-9--3--------------------------2-----9--3---------------
392058SchaapThe Agaricus bisporus pruA gen ...Agaricus bisporusAppl. Environ. Microbiol.6357-621997-11-----3--1-3---1-51-2--------1----111-------3--1-----51-2---------------
392060Forlani-Two DELTA1-pyrroline-5-carboxy ...Nicotiana plumbaginifoliaPlanta202242-2481997------14---1-1--1--12-1-----11-------------1-4---1---1-12-1-----11--------
392062ForlaniDELTA1-Pyrroline-5-carboxylate ...Solanum tuberosumPlant Physiol.1131413-14181997------23--11-3--1--11211112-1--2------2----2-3--11---1-11211112-1---------
392065FahmyEnzymes of DELTA1-pyrroline-5- ...Hyalomma dromedariiComp. Biochem. Physiol. B118229-2371997------1914--2--4--1--23-131----1---8----------19814--2----1-23-131----1---------
392064HuCloning characterization, and ...Homo sapiensJ. Biol. Chem.2719795-98001996--1-----1--1-5-----6--31-------1-----11-------1--1-----6--31--------------
392059Smith-Interaction between primary an ...Streptomyces coelicolorMicrobiology1411739-1744199511----32--11-1--11--1-11---1---12--11-1----322--11---1--1-11---1----------
392039SmallPyrroline 5-carboxylate dehydr ...Homo sapiens, Rattus norvegicusJ. Biol. Chem.26518668-186721990------432-2--6--1--21-42----1--2------2----4-32-2----1-21-42----1---------
392040HullCloning and physical character ...Emericella nidulansMol. Microbiol.3553-5591989--1----------1--------1--------------1--------------------1---------------
392041Isobe-Crystallization and characteri ...Bacillus caldotenax, Geobacillus stearothermophilus, Geobacillus thermodenitrificans, Lysinibacillus sphaericusAgric. Biol. Chem.511947-19531987---1-1-4--1--4--1---7-412-2-12-5------51-1---4--1----1--7-412-2-12--------
392042SmallA specific radiochemical assay ...Rattus norvegicusAnal. Biochem.161380-3861987--------1----2--1--11-1--------1------1-------1------1-11-1---------------
392043ThompsonRegional distribution in rat b ...Rattus norvegicusJ. Neurochem.451791-17961985-------------4-----31----------1------1----------------31-----------------
392057BrandrissProline utilization in Sacchar ...Saccharomyces cerevisiaeMol. Cell. Biol.31846-18561983-------------2------------------------------------------------------------
392044MenzelEnzymatic properties of the pu ...Salmonella enterica subsp. enterica serovar TyphimuriumJ. Biol. Chem.2569762-97661981------311----1---1----2--------1------1----3-11-----------2---------------
392045MenzelPurification of the putA gene ...Salmonella enterica subsp. enterica serovar TyphimuriumJ. Biol. Chem.2569755-97611981-------1--1--2--1---2122---------------------1--1----1--2122--------------
392046BrandrissProline: an essential intermed ...Saccharomyces cerevisiaeJ. Bacteriol.1431403-14101980----1--------3------2-1--------1------1-1---------------2-1---------------
392047HerzfeldEnzymes metabolizing delta1-py ...Rattus norvegicusBiochem. J.16695-1031977------41-----2-----3--2-----1--1------1----4-1---------3--2-----1---------
392048BoggessDELTA1-pyrroline-5-carboxylic ...Hordeum vulgare subsp. vulgarePlant Physiol.56259-2621975------211----1-----1--1-----1--------------2-11--------1--1-----1---------
392049Stewart-DELTA1-pyrroline-5-carboxylic ...Cucurbita maxima, Pisum sativum, Ricinus communis, Zea maysPlant Sci. Lett.3173-1811974------44-4----4--1--10--8-----11-8------8----44--4------1-10--8-----11--------
392050LundgrenInhibition of yeast 1 -pyrroli ...Saccharomyces sp.Biochim. Biophys. Acta297246-2571973------111-----1-----------------------------11-1----------------------------
392051DendingerEffect of the proline analogue ...Salmonella enterica subsp. enterica serovar TyphimuriumJ. Bacteriol.1121134-11411972------11-----1---1----1--------------------1-1------------1---------------
392052LundgrenAmino acid inhibition of a 1 - ...Bos taurusBiochem. Biophys. Res. Commun.49147-1491972------5-1----1-----1-----------------------5--1--------1------------------
392053Strecker-DELTA1-pyrroline-5-carboxylate ...Bos taurusMethods Enzymol.17B262-2651971------104-----1--1--1111-----1--2------2----10-4-------1-1111-----1---------
392054BrunnerLocalisation of proline oxidas ...Rattus norvegicusFEBS Lett.3283-2861969--------2----1-----1--------------------------2--------1------------------
392055AdamsHydroxyproline metabolism. IV. ...Bos taurusJ. Biol. Chem.2353504-35121960-----18------1--1--11-2-----1------------1-8---------1-11-2-----1---------
392056Strecker-The interconversion of glutami ...Bos taurusJ. Biol. Chem.2353218-32231960------10------1-----1112-----11-2------2----10-----------1112-----11--------