Decreased serum activity of semicarbazide-sensitive amine oxidase (SSAO) in patients treated with second generation antipsychotics: a link to impaired glucose metabolism ?

Roessner, V.; Weber, A.; Becker, A.; Beck, G.; Frieling, H.; Bleich, S.; Eur. J. Clin. Pharmacol. 63, 425-429 (2007)

 show all sequences of 1.4.3.21

Data extracted from this reference:

Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Homo sapiens
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-
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Source Tissue
Source Tissue Commentary Organism Textmining
blood serum decreased SSAO serum activity in schizophrenic patients treated with second generation antipsychotics known to disturb glucose metabolism Homo sapiens
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Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
benzylamine + H2O + O2
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 686502 Homo sapiens benzaldehyde + NH3 + H2O2
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 ?
Source Tissue (protein specific)
Source Tissue Commentary Organism Textmining
blood serum decreased SSAO serum activity in schizophrenic patients treated with second generation antipsychotics known to disturb glucose metabolism Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
benzylamine + H2O + O2
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 686502 Homo sapiens benzaldehyde + NH3 + H2O2
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 ?

See also following references to EC number 1.4.3.21 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
710834StevanatoPreliminary kinetic characteri ...Rattus norvegicusAmino Acids40713-7202010-------121---4-----2--1------1---------------121-------2--1------1--------
711430LiangA conformationally constrained ...Homo sapiensBioorg. Med. Chem. Lett.206721-67242010--1---1-11-1-1--------31-------1-----11----1--11-1--------31--------------
711738HaiderSynthesis of ortho-functionali ...Homo sapiensChem. Pharm. Bull.58964-9702010------12--1---1--------------1-----1-------112---1----------------1---------
712709NurminenSynthesis, in vitro activity, ...Homo sapiensJ. Med. Chem.536301-63152010-11---54--1-1-2--------2-1---1-------11-----54---1-1--------2-1---1---------
701561NunesSemicarbazide-sensitive amine ...Homo sapiensActa Diabetol.46135-1402009---------1-2-1-----10--3-1---1--1------1--------1-2-----10--3-1---1----11---
701612BourSemicarbazide-sensitive amine ...Mus musculusAm. J. Pathol.1741075-10832009----1---1----4-----3--------------------1-----1--------3------------1221--
703130KaitaniemiThe unique substrate specifici ...Homo sapiensCell. Mol. Life Sci.662743-27572009--1-1-5821-7-4-----14--111--------3----2--1--73932-8-----16--122--------------
705350Iffiu-SolteszInfluence of prolonged fasting ...Rattus norvegicusJ. Physiol. Biochem.6511-2320091-----2-1----4-----1--2------------1-------2--1--------1--2---------------
705496VavilovaMonoamine oxidase and semicarb ...Homo sapiensMed. Sci. Monit.15BR289-BR2922009------1----1-1-----1--1--------------------1-----1-----1--1----------11---
712188MarteliusInhibition of semicarbazide-se ...Rattus norvegicusInt. J. Immunopathol. Pharmacol.21911-9202009------1-21---3-----5--11-------------------1--21-------5--11---------11---
684124DaiSynthetic liver X receptor ago ...Mus musculusActa Biochim. Biophys. Sin. (Shanghai)40261-2682008-----------1-1--------2--------------------------1--------2---------------
686264DunkelSemicarbazide-sensitive amine ...Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicusCurr. Med. Chem.151827-18392008------45------6-----5--26-----------45-------4545-----------5--26---------------
686850LinAntioxidant, anti-semicarbazid ...Bos taurusFood Chem. Toxicol.462485-24922008------1------1-----1--1---------1-1-------111----------1--1---------------
687077FracassiniEndogenous substrates of the s ...Rattus norvegicusInflamm. Res.57S53-S542008------1------1-----1--1--------------------1-----------1--1---------------
687307LangleyEnantiomer-specific binding of ...Arthrobacter globiformisJ. Am. Chem. Soc.1308069-80782008---1--1------3--------1----------------1---1--------------1---------------
687459LeePurification and characterizat ...Mycobacterium sp.J. Biochem.144107-1142008------62-12--2--1--12-32----1--1------1----6-2-12----1-12-32----1---------
688002WiwanitkitSynergistic interaction betwee ...Homo sapiensJ. Diabetes Complicat.22413-4192008-----------1-1--------1--------------------------1--------1---------------
688100AnHydrogen peroxide generated by ...Vicia fabaJ. Exp. Bot.59815-8252008-------------3-----1-----------------------------------1------------------
688553SibonAssociation between semicarbaz ...Rattus norvegicusJ. Neurosurg.108558-5662008-------------1--------1-----------------------------------1---------------
688603ORourkeAnti-inflammatory effects of L ...Homo sapiens, Mus musculus, Rattus norvegicusJ. Pharmacol. Exp. Ther.324867-8752008------3------3-----3--3-----------4-------43-----------3--3---------------
689200JiangThe contribution of cerebral v ...Homo sapiensNeuropathol. Appl. Neurobiol.34194-2042008-------------1-----1-----------------------------------1------------------
689377CarpeneLimitation of adipose tissue e ...Rattus norvegicusPharmacol. Res.57426-4342008------2------4-----3--1--------------------2-----------3--1---------------
701483PirratStructure of a xenon derivativ ...Escherichia coliActa Crystallogr. Sect. F641105-11092008---1-----1---2--------11-------1------11-------1----------11--------------
701487AtkinCloning, expression, purificat ...Aspergillus nigerActa Crystallogr. Sect. F64182-1852008--113-2------1--1-----11-------1-----1113--2---------1----11--------------
701490LangleyComplexes of the copper-contai ...Arthrobacter globiformisActa Crystallogr. Sect. F64577-5832008---1--2--1---3-----------------1------11---2---1--------------------------
703506PeterCopper distributed by Atx1 is ...no activity in Saccharomyces cerevisiae, Schizosaccharomyces pombeEukaryot. Cell71781-179420082-1-5----1-1-5--------211---1--1---2-11-5------1-1--------211---1----11---
705128AtkinThe structure of monoamine oxi ...Aspergillus nigerJ. Mol. Biol.3841218-12312008--112------1-1-11-----11-------1-----1112--------1--11----11--------------
684285GokturkMacrovascular changes in mice ...Homo sapiensAm. J. Hypertens.20743-7502007--1--------1-1--------2--------------1-----------1--------2---------------
684685Di PaoloN-alkanamines as substrates to ...Bos taurusArch. Biochem. Biophys.46550-602007-------------3--1--1--6------------------------------1-1--6---------------
685663WangDPPH radical scavenging and se ...Homo sapiens, Mus musculusBiosci. Biotechnol. Biochem.711873-18782007------2------2-----2--2--------------------2-----------2--2---------------
686052YraolaUnderstanding the mechanism of ...Homo sapiens, Mus musculus, Rattus norvegicusChem. Biol. Drug Des.69423-4282007-3-----62----3-----2--6-------------3--------62--------2--6---------------
686502RoessnerDecreased serum activity of se ...Homo sapiensEur. J. Clin. Pharmacol.63425-4292007-------------1-----1--1--------------------------------1--1---------------
687276MooreTrapping of a dopaquinone inte ...Arthrobacter globiformisJ. Am. Chem. Soc.12911524-115342007---12----1---3--1-----1--------1------112------1-----1----1---------------
687449Hernandez-GuillamonSodium bicarbonate enhances me ...Homo sapiensJ. Biochem.142571-5762007--------21---1-----2--1-----------------------21-------2--1---------------
688255LeonettiSolid-phase synthesis and insi ...Homo sapiensJ. Med. Chem.504909-49162007------1------1-----2--1--------------------1-----------2--1---------------
688482OlivieriL-lysine as a recognition mole ...Bos taurusJ. Neural Transm.114747-7492007------1----1-1-----1--2---------1----------11----1-----1--2---------------
688483O'SullivanHydrogen peroxide derived from ...Bos taurusJ. Neural Transm.114751-7562007------1------2-----1--1--------------------1-----------1--1---------------
688484YabanogluInteraction of rat lung SSAO w ...Rattus norvegicusJ. Neural Transm.114769-7732007------4---1--1--1--11-11--------8----------48---1----1-11-11--------------
688487BourSemicarbazide-sensitive amine ...Mus musculusJ. Neural Transm.114829-8332007-------------4-----2--1--------------------------------2--1---------------
688488NemcsikAlteration of serum semicarbaz ...Homo sapiensJ. Neural Transm.114841-8432007-------------1-----1--1--------------------------------1--1---------------
688489SolteszStudies on the insulinomimetic ...Rattus norvegicusJ. Neural Transm.114851-8552007-------------4-----1--1--------------------------------1--1---------------
688490UnzetaSemicarbazide-sensitive amine ...Homo sapiensJ. Neural Transm.114857-8622007-----------1-1-----2--1--------------------------1-----2--1---------------
688491VidrioHypotensive effect of hydroxyl ...Rattus norvegicusJ. Neural Transm.114863-8652007------1------1--------1--------------------1--------------1---------------
688757TakahashiAbsence of tissue-bound semica ...no activity in Cyprinus carpioLife Sci.801094-10992007-------------1------------------------------------------------------------
689375CarpeneReduction of fat deposition by ...Rattus norvegicusPharmacol. Res.56522-5302007------1------2-----1--2--------------------1-----------1--2---------------
689376PrevotProlonged treatment with amino ...Rattus norvegicusPharmacol. Res.5670-792007------1------1-----1--1--------------------1-----------1--1---------------
671747MurakawaQuantum mechanical hydrogen tu ...Arthrobacter globiformisBiochem. Biophys. Res. Commun.342414-4232006-------------2--------1-----------------------------------1---------------
672133DuBoisRole of a strictly conserved a ...Pichia angustaBiochemistry453178-31882006----2--------4--------3----3------------2-----------------3----3----------
672146ChiuKinetic and structural studies ...Arthrobacter globiformisBiochemistry454105-41202006----1--2-----4--------1----2-1----------1----2------------1----2-1--------
672152TakahashiRelationship of stopped flow t ...Pichia angustaBiochemistry454683-46942006---------2---5--------1------------------------2----------1---------------
672492OchiaiSubstrate selectivity of monoa ...Rattus norvegicusBiol. Pharm. Bull.292362-23662006--1---2------1------9-5--------------1-----2------------9-5---------------
671976OkajimaReinvestigation of metal ion s ...Arthrobacter globiformisBiochemistry4412041-120482005---1---2-4---4--1-----1----3-----------1-----2-4-----1----1----3----------
675286BertiniAlkylamino derivatives of 4-am ...Pichia angusta, Pisum sativum, Sus scrofaJ. Med. Chem.48664-6702005------472-1---6-----2--6-----------37-------3747-2-1-------2--6---------------
676364LonguMechanism-based inactivators o ...Lathyrus sativus, Lens culinaris, Onobrychis viciifolia, Pisum sativumPhytochemistry661751-17582005------383-4---4-4---2--371---2---45-----4----3853-4----4--2--371---2----------
655782KishishitaRole of copper ion in bacteria ...Arthrobacter globiformisJ. Am. Chem. Soc.1251041-10552003---1---6-3---3--1-----1----6-----------1-----6-3-----1----1----6----------
654501SaysellProbing the catalytic mechanis ...Escherichia coliBiochem. J.365809-8162002----2-19-1---3------2-1----11---1------1-2--1-9-1--------2-1----11----------
654616MillsMechanistic comparison of the ...Pichia angustaBiochemistry4110577-105842002-------1-2---4--------1----2-----------------1-2----------1----2----------
655781Lee3-Pyrrolines are mechanism-bas ...Bos taurusJ. Am. Chem. Soc.12412135-121432002------9--1---1-----2--1--------1------1----9---1-------2--1---------------
391960Mills-Evidence against reduction of ...Pichia angustaJ. Am. Chem. Soc.1229897-99042000--1----2-1---1--11--6-2----2---------1-------2-1-----1--6-2----2----------
391956LiCopper amine oxidase from Hans ...Pichia angustaStructure6293-3071998---1----1----5---1----1----------------1------1-----------1---------------
391949CaiCopper amine oxidase: heterolo ...Pichia angustaBiochemistry337647-76531994--1----311---5--1---1-3--------1-----11------311-----1--1-3---------------
391937HysmithPurification of benzylamine ox ...Sus scrofaBiochem. Cell Biol.66821-8291988------51-----2--1--21-21-------------------5-1-------1-21-21--------------
391914FalkHeterogeneity of pig plasma am ...Sus scrofaBiochemistry223746-37511983------11-11--1-11--11-21---1---1------1----1-1-11---11-11-21---1----------
391932BarkerProperties of cupric ions in b ...Sus scrofaBiochem. J.177289-3021979------3--11--3-----2--11--------5----------35--11------2--11--------------
391910Carper-Pig liver monoamine oxidase I: ...Sus scrofaBiochim. Biophys. Acta334287-2961974---1--52-41--1-----11-2111--11---------1---5-2-41------11-2111--11--------
391915LindströmEffect of azide on some spectr ...Sus scrofaEur. J. Biochem.48237-2431974------4--1---1-----1--1--------11-----1----41--1-------1--1---------------
391916LindströmKinetics of the interaction be ...Sus scrofaEur. J. Biochem.42177-1821974------2------1-----1--1--------1------1----2-----------1--1---------------
391908YamadaMonoamine oxidase II. Copper, ...Bos taurusJ. Biol. Chem.2373077-30821962------61-1---1--1--1--2---------1----------611-1-----1-1--2---------------