Different patterns of 5alpha-reductase expression, cellular distribution, and testosterone metabolism in human follicular dermal papilla cells

Liu, S.; Yamauchi, H.; Biochem. Biophys. Res. Commun. 368, 858-864 (2008)

 show all sequences of 1.3.1.22

Data extracted from this reference:

Inhibitors
Inhibitors Commentary Organism Structure
finasteride 5alphaR2 inhibitor Homo sapiens
MK386 potent inhibitory effect on 5alphaR1 Homo sapiens
Localization
Localization Commentary Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
Molecular Weight [Da]
Molecular Weight [Da] Molecular Weight Maximum [Da] Commentary Organism
26000
-
 5alphaR1, SDS-PAGE Homo sapiens
Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue Commentary Organism Textmining
DPC cell from beard and axillary hair and frontal scalp hair Homo sapiens
-
fibroblast
-
 Homo sapiens
-
follicular dermal papilla cell
-
 Homo sapiens
-
Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
progesterone + NADPH
-
 684907 Homo sapiens 5alpha-pregnan-3,20-dione + NADP+
-
-
-
 ?
testosterone + NADPH
-
 684907 Homo sapiens 17beta-hydroxy-5alpha-androstan-3-one + NADP+
-
-
-
 ?
Cofactor
Cofactor Commentary Organism Structure
NADPH
-
 Homo sapiens
IC50 Value
IC50 Value IC50 Value Maximum Commentary Organism Inhibitor Structure
0.0005
-
-
 Homo sapiens MK386
0.008
-
-
 Homo sapiens finasteride
Cofactor (protein specific)
Cofactor Commentary Organism Structure
NADPH
-
 Homo sapiens
IC50 Value (protein specific)
IC50 Value IC50 Value Maximum Commentary Organism Inhibitor Structure
0.0005
-
-
 Homo sapiens MK386
0.008
-
-
 Homo sapiens finasteride
Inhibitors (protein specific)
Inhibitors Commentary Organism Structure
finasteride 5alphaR2 inhibitor Homo sapiens
MK386 potent inhibitory effect on 5alphaR1 Homo sapiens
Localization (protein specific)
Localization Commentary Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da] Molecular Weight Maximum [Da] Commentary Organism
26000
-
 5alphaR1, SDS-PAGE Homo sapiens
Source Tissue (protein specific)
Source Tissue Commentary Organism Textmining
DPC cell from beard and axillary hair and frontal scalp hair Homo sapiens
-
fibroblast
-
 Homo sapiens
-
follicular dermal papilla cell
-
 Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
progesterone + NADPH
-
 684907 Homo sapiens 5alpha-pregnan-3,20-dione + NADP+
-
-
-
 ?
testosterone + NADPH
-
 684907 Homo sapiens 17beta-hydroxy-5alpha-androstan-3-one + NADP+
-
-
-
 ?

See also following references to EC number 1.3.1.22 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
684907LiuDifferent patterns of 5alpha-r ...Homo sapiensBiochem. Biophys. Res. Commun.368858-8642008------2-1-1--1-----3--2--------1--2---1---22--1-1------3--2---------------
685780CarneiroAndrogen receptor and 5alpha-r ...Homo sapiensBJOG115113-1172008-------------2-----1--1--------1------1----------------1--1---------------
687218SanchezEffects of sulpiride on mRNA l ...Rattus norvegicusIUBMB Life6068-7220081------------4-----1--1--------1---2--2----------------2--2---------------
688720AmoryThe effect of 5alpha-reductase ...Homo sapiensJ. Urol.1792333-23382008------2------1--------1--------1------1----2--------------1---------------
689176SanchezEffects of swim stress on mRNA ...Rattus norvegicusNeurochem. Int.52426-4312008--------1-1--2-----1--1--------1------2-------2-2------2--2---------------
689849AssinderOxytocin increases 5alpha -red ...Homo sapiensProstate68115-12120082------------1-----5--1--------1---2--1----------------5--1---------------
685457HirataTestosterone 5alpha-reductase ...Rattus norvegicusBiol. Pharm. Bull.302402-24052007------5------1-----1--1--------1--4---1---45-----------1--1---------------
686332OnenThe association of 5alpha-redu ...Homo sapiensDNA Cell Biol.26100-1072007-------------1-----1--1--------1------1----------------1--1---------------
688684BratoeffSteroids with a carbamate func ...Homo sapiens, Mesocricetus auratusJ. Steroid Biochem. Mol. Biol.10748-562007------6-2----2-----2--2--------2--3---2---36--2--------2--2---------------
675475MakridakisPharmacogenetic analysis of hu ...Homo sapiensJ. Mol. Endocrinol.34617-6232005-1--19-2------1-----1------------5---1---19--25----------1------------------
675683GuzmanEffect of testosterone and ste ...Rattus norvegicusJ. Steroid Biochem. Mol. Biol.94369-37320053------------1-----1---------------3-------------------1------------------
676162SanchezEffects of dihydrotestosterone ...Rattus norvegicusNeurochem. Res.30577-581200511----1------3-----3---------------11------1-----------3------------------
676930ThomasDifferential alterations in 5a ...Homo sapiensProstate63231-2392005-11-------1--1-----1----------------11----------1------1------------------
655182LeeTheaflavin-3,3'-digallate and ...Homo sapiens, Rattus norvegicusCarcinogenesis251109-11182004------811--2-2-----6--4-2---2--27-----2----8711--2-----6--4-2---2---------
655238CabezaNovel 17 substituted pregnadie ...Mesocricetus auratusChem.Pharm. Bull.52535-5392004------6-1--1-1-----1--1-1---1--1------1----6--1--1-----1--1-1---1---------
655351AssinderRegulation of 5alpha-reductase ...Rattus norvegicusEndocrinology1455767-57732004-------------1-----1-----------------------------------1------------------
656656OcchiatoSelective non-steroidal inhibi ...Homo sapiensJ. Steroid Biochem. Mol. Biol.881-162004-11---64----1-1---1-5--2--------117-1-111---16417----1-----5--2---------------
656790MahendrooSteroid 5alpha-reductase 1 pro ...Mus musculusMol. Cell. Endocrinol.222113-1202004-------------1-----1-----------------------------------1------------------
657214ShirakawaMessenger RNA levels and enzym ...Homo sapiensProstate5833-402004-------------1-----3--------2--------------------------3--------2---------
657354WoelflingNeighboring group participatio ...Homo sapiensSteroids69451-4602004------9------1-----1--1-1------1------1----9-----------1--1-1-------------
654933Killian5alpha-reductase isoenzymes 1 ...Rattus norvegicusBiol. Reprod.681711-17182003------1----1-1-----1--1--------------------1-----1-----1--1---------------
656373PratisDifferential regulation of rat ...Rattus norvegicusJ. Endocrinol.176393-4032003-------------1-----1-----------------------------------1------------------
657353FloresEffect of a novel steroid (PM- ...Penicillium crustosumSteroids68271-2752003------21-----1-----1--1---------2----------221---------1--1---------------
654925MatsudaAnti-androgenic and hair growt ...Rattus norvegicusBiol. Pharm. Bull.25622-6262002------6------1-----1-----------------------6-----------1------------------
656380PicardN-Substituted 4-(4-carboxyphen ...Homo sapiens, Rattus norvegicusJ. Enzyme Inhib. Med. Chem.17187-1962002------34------2-----2-----------------------34-----------2------------------
656458PicardSynthesis and evaluation of 2' ...Homo sapiens, Rattus norvegicusJ. Med. Chem.453406-34172002------32------2-----2-----------------------32-----------2------------------
656647RaynaudInhibition of type 1 and type ...Homo sapiensJ. Steroid Biochem. Mol. Biol.82233-2392002------11------1--------------2--------------11--------------------2---------
656681RanjanComparative study of human ste ...Homo sapiensLife Sci.71115-1262002------23-----1-----2--1---------6----------263---------2--1---------------
657040BasseEvidence for a Ustilago maydis ...Ustilago maydisPlant Physiol.129717-7322002----1---1----1---------1----------------1-----1------------1--------------
396224BaxterStructure-function studies of ...Homo sapiensJ. Steroid Biochem. Mol. Biol.77167-1752001------1------1-----------------------------1------------------------------
396222CookeThe effects of progesterone, 4 ...Homo sapiens, Sus scrofaJ. Steroid Biochem. Mol. Biol.60353-3591997------713----6-----2--1-----2---4----------7413--------2--1-----2---------
396223KaeferCharaterization of type I 5alp ...Homo sapiensJ. Steroid Biochem. Mol. Biol.58195-2051996-------------1-----1--1--------------------------------1--1---------------
396214BhattacharyyaIdentification of the NADP(H) ...Rattus norvegicusBiochemistry343663-36691995------2-1-1--1--1--1-----------1------1----2--1-1----1-1------------------
396215TianMechanism of time-dependent in ...Homo sapiensBiochemistry3413453-134591995------221----1--------1---------1----------2121-----------1---------------
396219LevyCloning, expression and functi ...Homo sapiens, Macaca fascicularis, Rattus norvegicusJ. Steroid Biochem. Mol. Biol.52307-3191995--1---1218-----3-----3--14-----44--18----1-----121818---------3--14-----44--------
396220SpanRat steroid 5alpha-reductase k ...Rattus norvegicusJ. Steroid Biochem. Mol. Biol.54185-1921995-------2-----1-----2--------2----------------2---------2--------2---------
396216WigleyNatural mutagenesis study of t ...Homo sapiensBiochemistry331265-12701994----10--19-----1--------1-----3--1------1-10----19------------1-----3---------
396217Quemener-Glyosylated nature of testoste ...Homo sapiensBiochem. Biophys. Res. Commun.205296-2741994-----1----1--1--1--1--1------------------1------1----1-1--1---------------
396218DelosInhibition of the activity of ...Homo sapiens, Spodoptera frugiperdaJ. Steroid Biochem. Mol. Biol.48347-3521994------5------2-----1--2---------2----------52----------1--2---------------
396221BeckmannInfluence of steroid hormones ...Homo sapiensActa Endocrinol.128161-16719933-----1------1-----1---------------3-------1-----------1------------------
396192Enderle-SchmittSolubilization of nuclear ster ...Rattus norvegicusBiochim. Biophys. Acta98721-281989------1-1--1-3-----1--2---2----2------2----1--1--1-----1--2---2-----------
396194Watkins-Properties of 4-ene-5alpha-red ...Sus scrofaBiochem. Soc. Trans.14339-3401986-------11--1-1-----1--2-1---1--2------2------11--1-----1--2-1---1---------
396197Watkins-Solubilization of 4-ene-5alpha ...Sus scrofaBiochem. Soc. Trans.149791986--------1----1-----1--1--------1------1-------1--------1--1---------------
396203Kondo-Hormonal regulation of activit ...Rattus norvegicusJ. Steroid Biochem.13703-7051986-------------1-----1--1--------1------1----------------1--1---------------
396195Watkins-DELTA4-Steroid 5alpha-reductas ...Sus scrofaBiochem. Soc. Trans.13187-1881985-------------1-------11-----1--1------1------------------11-----1---------
396210ScheerSolubilization and partial cha ...Rattus norvegicusBiochem. J.21165-741983------432----1-----1-12-----11-1------1----4-32--------1-12-----11--------
396213JurmanTestosterone 5alpha-reductase ...Xenopus laevisJ. Neurochem.38657-6611982-------1-----1-----1--2-11--11-1------1------1---------1--2-11--11--------
396199GraefNADPH: 4-ene-3-oxosteroid-5alp ...Chinchilla brevicaudata, Gallus gallus, Homo sapiens, Mesocricetus auratus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofaJ. Steroid Biochem.14883-8871981--------8----8-----84-8-----4--8------8-------8--------84-8-----4---------
396200LotzImportance of 5alpha-reduction ...Rattus norvegicusJ. Steroid Biochem.131261-12641980-------------1-----1--1--------2------2----------------1--1---------------
396201SholitonRat thymic homogenates convert ...Rattus norvegicusJ. Steroid Biochem.131365-13671980-------------1-----1--2--------1------1----------------1--2---------------
396202ThouvenotInterferences of zearalenone, ...Homo sapiensJ. Steroid Biochem.131337-13451980------12-----1-----1--2--------1------1----1-2---------1--2---------------
396204BlohmInhibition of testosterone 5al ...Rattus norvegicusBiochem. Biophys. Res. Commun.95273-2801980------1-1----1-----1--1--------11-----1----11-1--------1--1---------------
396205KoninckxBiochemical characterization o ...Rattus norvegicusJ. Steroid Biochem.10325-3331979------22-----1-----1--2-----11-1------1----2-2---------1--2-----11--------
396211CowanTestosterone 5alpha-reductase ...Homo sapiensJ. Steroid Biochem.11609-6131979--------1----1-----1--1--------1------1-------1--------1--1---------------
390592WiltonIs a Schiff base involved in t ...Rattus norvegicusBiochem. J.155487-4911976--------1----1-----1--2--------1------1-------1--------1--2---------------
396207MooreSteroid 5alpha-reductase in cu ...Homo sapiensJ. Biol. Chem.2515895-59001976--------1----1-----2--2-----2--1------1-------1--------2--2-----2---------
396193MooreReduced nicotinamide adenine d ...Rattus norvegicusMethods Enzymol.36A466-4741975------512----1--1--61210---1-1--2------2----5-12------1-61210---1-1---------
396208WallaceEffect of zinc on androgen met ...Homo sapiensBiochem. Soc. Trans.3540-5421975------1-2----1-----1--1--------1------1----1--2--------1--1---------------
396209MooreExtraction of the reduced nico ...Rattus norvegicusBiochemistry13450-4561974-----2--3-1--1--1--11-1-----1-21------1--2----3-1----1-11-1-----1-2-------
396206VoigtFurther studies on testosteron ...Homo sapiensJ. Biol. Chem.2484280-42851973------4-1----1-----1--1--------1------1----4--1--------1--1---------------
396196FrederiksenPartial characterization of th ...Rattus norvegicusJ. Biol. Chem.2462584-25931971-------------1-----1--1--------2------2----------------1--1---------------
396212Shefer-Studies on the biosynthesis of ...Rattus norvegicusJ. Biol. Chem.241946-9521965------4-2----1-----1--1-----1--2------2----4--2--------1--1-----1---------