Deoxyribonucleotide biosynthesis in green algae. Purification and characterization of ribonucleotide-diphosphate reductase from Scenedesmus obliquus

Hofmann, R.; Feller, W.; Pries, M.; Follmann, H.; Biochim. Biophys. Acta 832, 98-112 (1985)

 show all sequences of 1.17.4.1

Data extracted from this reference:

Activating Compound
Activating Compound Commentary Organism Structure
dithiothreitol high concentrations serve as in vitro hydrogen donor Scenedesmus obliquus
additional information stimulation by effector nucleotides; stimulation with various substrates Scenedesmus obliquus
-
phosphate up to 50 mM, pH 6.7: necessary for activity, decrease of activity at higher values Scenedesmus obliquus
Inhibitors
Inhibitors Commentary Organism Structure
1,10-phenanthroline 0.2 mM, 50% inhibition Scenedesmus obliquus
aurintricarboxylate 0.005 mM, 50% inhibition; oligomeric form Scenedesmus obliquus
dATP
-
 Scenedesmus obliquus
EDTA 10 mM, 50% inhibition Scenedesmus obliquus
Fe2+ 0.2 mM, 50% inhibition Scenedesmus obliquus
Hydroxyurea 1.5 mM, 50% inhibition Scenedesmus obliquus
Mg2+ 2 mM, 50% inhibition Scenedesmus obliquus
Mn2+ 0.2 mM, 50% inhibition Scenedesmus obliquus
N-Hydroxy-alpha-aminoheptanoate 5 mM, 50% inhibition Scenedesmus obliquus
N-Hydroxy-alpha-aminohexanoate 15 mM, 50% inhibition Scenedesmus obliquus
Natural Substrates/ Products (Substrates)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
ribonucleoside diphosphate + reduced thioredoxin Scenedesmus obliquus thioredoxin is the physiological reductant 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin
-
 Scenedesmus obliquus
-
Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Scenedesmus obliquus
-
-
-
Purification (Commentary)
Commentary Organism
-
 Scenedesmus obliquus
Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
ribonucleoside diphosphate + reduced thioredoxin high concentration of dithiothreitol serves as in vitro hydrogen donor, thioredoxin B of Scenedesmus obliqus and yeast thioredoxin are most effective donors 437932 Scenedesmus obliquus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 437932 Scenedesmus obliquus ir
ribonucleoside diphosphate + reduced thioredoxin thioredoxin is the physiological reductant 437932 Scenedesmus obliquus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin
-
 437932 Scenedesmus obliquus
-
Subunits
Subunits Commentary Organism
? 2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE Scenedesmus obliquus
Temperature Optimum [°C]
Temperature Optimum [°C] Temperature Optimum Maximum [°C] Commentary Organism
25 30
-
 Scenedesmus obliquus
Temperature Range [°C]
Temperature Minimum [°C] Temperature Maximum [°C] Commentary Organism
15 42 15°C: approx. 27% activity, 42°C: approx. 10% activity Scenedesmus obliquus
pH Optimum
pH Optimum Minimum pH Optimum Maximum Commentary Organism
6.5 7
-
 Scenedesmus obliquus
Activating Compound (protein specific)
Activating Compound Commentary Organism Structure
dithiothreitol high concentrations serve as in vitro hydrogen donor Scenedesmus obliquus
additional information stimulation by effector nucleotides; stimulation with various substrates Scenedesmus obliquus
-
phosphate up to 50 mM, pH 6.7: necessary for activity, decrease of activity at higher values Scenedesmus obliquus
Inhibitors (protein specific)
Inhibitors Commentary Organism Structure
1,10-phenanthroline 0.2 mM, 50% inhibition Scenedesmus obliquus
aurintricarboxylate 0.005 mM, 50% inhibition; oligomeric form Scenedesmus obliquus
dATP
-
 Scenedesmus obliquus
EDTA 10 mM, 50% inhibition Scenedesmus obliquus
Fe2+ 0.2 mM, 50% inhibition Scenedesmus obliquus
Hydroxyurea 1.5 mM, 50% inhibition Scenedesmus obliquus
Mg2+ 2 mM, 50% inhibition Scenedesmus obliquus
Mn2+ 0.2 mM, 50% inhibition Scenedesmus obliquus
N-Hydroxy-alpha-aminoheptanoate 5 mM, 50% inhibition Scenedesmus obliquus
N-Hydroxy-alpha-aminohexanoate 15 mM, 50% inhibition Scenedesmus obliquus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
ribonucleoside diphosphate + reduced thioredoxin Scenedesmus obliquus thioredoxin is the physiological reductant 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin
-
 Scenedesmus obliquus
-
Purification (Commentary) (protein specific)
Commentary Organism
-
 Scenedesmus obliquus
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
ribonucleoside diphosphate + reduced thioredoxin high concentration of dithiothreitol serves as in vitro hydrogen donor, thioredoxin B of Scenedesmus obliqus and yeast thioredoxin are most effective donors 437932 Scenedesmus obliquus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 437932 Scenedesmus obliquus ir
ribonucleoside diphosphate + reduced thioredoxin thioredoxin is the physiological reductant 437932 Scenedesmus obliquus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin
-
 437932 Scenedesmus obliquus
-
Subunits (protein specific)
Subunits Commentary Organism
? 2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE Scenedesmus obliquus
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C] Temperature Optimum Maximum [°C] Commentary Organism
25 30
-
 Scenedesmus obliquus
Temperature Range [°C] (protein specific)
Temperature Minimum [°C] Temperature Maximum [°C] Commentary Organism
15 42 15°C: approx. 27% activity, 42°C: approx. 10% activity Scenedesmus obliquus
pH Optimum (protein specific)
pH Optimum Minimum pH Optimum Maximum Commentary Organism
6.5 7
-
 Scenedesmus obliquus

See also following references to EC number 1.17.4.1 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
714233SeyedsayamdostUse of 2,3,5-F(3)Y-beta2 and 3 ...Escherichia coliBiochemistry501403-141120111------1-1-1-1--------21----11-----1---------1-1-1--------21----11---11---
714236CotruvoEscherichia coli class Ib ribo ...Escherichia coli, Escherichia coli GR536Biochemistry501672-16812011---------2---4--1-------1---1--3------3--------2-----1------1---1----11---
714258ZhangBacillus subtilis class Ib rib ...Bacillus subtilis, Bacillus subtilis JH624Biochemistry505615-562320112-1------2---5--1-----211---1------2-1---------2-----1----211---1---13311133--
715170HanDFT calculations for intermedi ...Escherichia coliInorg. Chem.502302-23202011---------3---3--------11-------1------1--------3----------11--------------
716143Sanchez-RomeroOrganization of ribonucleoside ...Escherichia coli, Escherichia coli K-12 CM735Microbiology1572220-22252011--1-----2----4-----1---1-------------1--------2--------1---1---------11---
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716318FairmanStructural basis for allosteri ...Homo sapiensNat. Struct. Mol. Biol.18316-32220111--13--------1---------2-----------1---13------------------2---------11---
716792AyeClofarabine 5-di and -triphosp ...Homo sapiensProc. Natl. Acad. Sci. USA1089815-982020112-1-1-3--1---1--1------1--------2--2-1--1--32--1-----1-----1--------------
713645GurmuExpression, purification, crys ...Human herpesvirus 8Acta Crystallogr. Sect. F66734-7372010--11-----1---3--1-----12-------------1-1-------1-----1----12---------11---
714184CotruvoAn active dimanganese(III)-tyr ...Escherichia coliBiochemistry491297-130920102--------2---3---------11---1--2---2--2--------2-----------11---1---1111--
714196JiangTwo distinct mechanisms of ina ...Chlamydia trachomatisBiochemistry495340-53492010------1--2-1-5--------15-------1------1----1---2-1--------15--------------
714622Sanchez-RomeroCorrelation between ribonucleo ...Escherichia coliBMC Mol. Biol.11112010-------------3-------------------------------------------------------11---
715085HolmgrenThe use of thiols by ribonucle ...Escherichia coli, Homo sapiens, Lactobacillus leichmannii, Mus musculus, Saccharomyces cerevisiaeFree Radic. Biol. Med.491617-16282010------20--8-18-5--------2313-------27------27----20---8-18--------2313---------55---
716674PanosaRibonucleotide reductases of S ...Salmonella enterica subsp. enterica serovar TyphimuriumPLoS ONE5e113282010-------------1-------------------------------------------------------22---
716920BoalStructural basis for activatio ...Escherichia coliScience3291526-153020101--1-----2---2-----------------2---1--21-------2---------------------11---
701536OgataCrystallization and preliminar ...Corynebacterium ammoniagenesActa Crystallogr. Sect. F65878-8802009--33-----6-1-1--3-----1--------------3-3-------6-1---3----1---------------
702161ZhuInhibitory mechanisms of heter ...Homo sapiensBiochem. Pharmacol.781178-118520091-1---11--2---1--1--2--111---2------1-1-----11---2-----1-2--111---2----11---
702259Smith2.6 a X-ray crystal structure ...Homo sapiensBiochemistry4811134-1114120091-11--1--1-1-3--1-----11-----------1-1-1---1---1-1---1----11---------11---
703813AbbouniElectron paramagnetic resonanc ...Corynebacterium glutamicum, Corynebacterium glutamicum R163Free Radic. Res.43943-95020091-----4--2---7--1---1-12----------541------544---2-----1--1-12--------------
704176JensenPeroxo-type intermediates in c ...Escherichia coliJ. Am. Chem. Soc.13112155-1217120091---3----1---3---1----1------------1----3------1----------1---------------
704195OffenbacherRedox-linked structural change ...Escherichia coliJ. Am. Chem. Soc.1317496-74972009-------------1--------111---------------------------------111-------------
704612VoevodskayaRedox intermediates of the Mn- ...Chlamydia trachomatisJ. Biol. Chem.2844555-456620096--5--5--7---2--------155------1---6--15---5---7----------155-------------
706308YooRice virescent3 and stripe1 en ...Oryza sativaPlant Physiol.150388-4012009--1-1-1-1----2-----2---1-------------2--2--2--2--------4---2---------24---
706318RoaRibonucleotide reductase regul ...Arabidopsis thalianaPlant Physiol.151461-4712009--2-4------5-3--------5--------------5--5--------5--------5----------25---
685235JiangRapid and quantitative activat ...Chlamydia trachomatisBiochemistry474477-44832008115-----1---1-55-------155------6---115-6------1---1-5------155-------------
685275JiangBranched activation- and catal ...Chlamydia trachomatisBiochemistry478477-848420081-1-3----2-1-1--------1-5---1--6---1-16-3------2-1--------1-5---1---------
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688283CappellacciRibose-modified purine nucleos ...Homo sapiensJ. Med. Chem.514260-42692008------9------1-----6-----------------------9-----------6------------------
688286XuThe structural basis for pepti ...Saccharomyces cerevisiaeJ. Med. Chem.514653-46592008-1111-2----2-3--1-----21-------1--2-11111-22-----2---1----21--------------
688754KarpA phase I study of the novel r ...Homo sapiensLeuk. Res.3271-772008------2------1---------1-------------------2---------------1--------------
702216TomterCircular dichroism and magneti ...Bacillus cereusBiochemistry4711300-113092008--1---2--1---5--1--------------------1-----2---1-----1--------------------
702226JiangFormation and function of the ...Chlamydia trachomatis, Escherichia coliBiochemistry4713736-1374420081--------3-2-4--------46-------2---1--2--------3-2--------46--------------
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676901FriedrichInsertion of a homing endonucl ...Aeromonas phage Aeh1Proc. Natl. Acad. Sci. USA1046176-61812007----1--------4--------------------------1---------------------------------
677078CerqueiraRibonucleotide reductase: a cr ...Escherichia coliRecent Patents Anticancer Drug Discov.211-292007------3------1---1-------------------------3------------------------------
684464AvolioRNA interference targeting the ...Homo sapiensAnticancer Drugs18377-3882007----1------1-1-----3--21-------1------1-1--------1-----3--21--------------
685023SigmondThe synergistic interaction of ...Homo sapiensBiochem. Pharmacol.731548-15572007------3------1-----5---1-------------------3-----------5---1--------------
686137HeidelPotent siRNA inhibitors of rib ...Mus musculusClin. Cancer Res.132207-22152007-11-1--------1-----1----------------11--1--------------1------------------
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672909GautamSuppression of lung tumor form ...Homo sapiens, Mus musculusCancer Res.666497-65022006-2-----------2-----1----------------2------------------1------------------
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674627TorrentsRibonucleotide reductase modul ...Pseudomonas aeruginosaJ. Biol. Chem.28125287-2529620061---1-2--1---1------3-12-----------1----1--2---1--------3-12--------------
674631NarvaezThe involvement of Arg265 of m ...Mus musculusJ. Biol. Chem.28126022-260282006----4--------1------4-1-----------------4---------------4-1---------------
674645RofougaranEnzymatically active mammalian ...Mus musculusJ. Biol. Chem.28127705-277112006------2------1---------1-------------------2---------------1--------------
676853XuStructures of eukaryotic ribon ...Saccharomyces cerevisiaeProc. Natl. Acad. Sci. USA1034022-40272006---1---------1---1---------------------1----------------------------------
676854XuStructures of eukaryotic ribon ...Saccharomyces cerevisiaeProc. Natl. Acad. Sci. USA1034028-40332006---1---------1-------------------------1----------------------------------
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657780SchroederLoss of the tyrosyl radical in ...Homo sapiens, Mus musculusBiochem. Biophys. Res. Commun.326614-6172005------2------2-----2-----------------------2-----------2------------------
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659460BirganderNucleotide-dependent formation ...Escherichia coliJ. Biol. Chem.28014997-150032005----1------1-1--------31---1------------1--------1--------31---1----------
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660530Lang-Synthesis of 8-vinyladenosine ...Escherichia coliTetrahedron597315-73222003------1------1--------1--------------------1--------------1---------------
437988SmalleyAerobic-type ribonucleotide re ...Bacteroides fragilisJ. Bacteriol.184895-90320021-1---2------4---------------------1-1-----2------------------------------
437989YunFacile electron transfer durin ...Mus musculusBiochemistry41981-9902002--1-1----1---1---1-------------------1--1------1--------------------------
437990KashlanA comprehensive model for the ...Mus musculusBiochemistry41462-47420021------------1--------11---4-------1----------------------11---4----------
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437984NguyenPurification of ribonucleotide ...Saccharomyces cerevisiaeProc. Natl. Acad. Sci. USA9612339-123441999--1-1--------1------2-11-------------1--1---------------2-11--------------
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437982TongCharacterization of Y122F R2 o ...Escherichia coliBiochemistry375840-58481998--1-3----1---1--------11-------------1--3------1----------11--------------
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437979RacayPurification and partial chara ...Streptomyces aureofaciensBiochem. Mol. Biol. Int.38493-5001996---------11--1--1---1-11-----------------------11----1--1-11--------------
437977SinhababuHigh-performance liquid chroma ...Oryctolagus cuniculusArch. Biochem. Biophys.317285-29119953-----32-----4--1--11-1---------2--3-------322-------1-11-1---------------
437978Cory-Differential substrate propert ...Mus musculusPurine and pyrimidine metabolism in manVIII ed. (Sahota A. and Taylor M. ed.)631-6351995------2------1--------11-------------------2--------------11--------------
437975YoungRibonucleotide reductase: evid ...Homo sapiensBiochem. Biophys. Res. Commun.20346-521994--------1----1-----1--1-----------------------1--------1--1---------------
437976JordanA second class I ribonucleotid ...Escherichia coli, Salmonella enterica subsp. enterica serovar TyphimuriumProc. Natl. Acad. Sci. USA9112892-1289619946-----24-4---5--1---2-42----1------6-------2-4-4-----1--2-42----1---------
437973Ong2'-C-Methyladenosine and 2'-C- ...Corynebacterium nephridiiBiochemistry3211397-114041993------2------3--------3---------4----------24-------------3---------------
437974SlabaughVaccinia virus ribonucleotide ...Vaccinia virusJ. Biol. Chem.26817803-1781019936-1--2---1---1--1--4221-----11-----6-1---2-----1-----1-4221-----11--------
675339NordlundStructure and function of the ...Escherichia coliJ. Mol. Biol.232123-1641993---1-----1---1-------------------------1-------1--------------------------
437927SahlinActivation of the iron-contain ...Escherichia coliBiochem. Biophys. Res. Commun.167813-81819901--------1---1--------11-----------1-----------1----------11--------------
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437941NordlundThree-dimensional structure of ...Escherichia coliNature345593-5981990---1-----1---1--------1----------------1-------1----------1---------------
437925WhitefieldRibonucleotide reductase - new ...Rattus norvegicusAdv. Enzyme Regul.28113-1231989-------------1-----1--11-------------------------------1--11--------------
437926carterSelective resistance of L1210 ...Mus musculusAdv. Enzyme Regul.29123-1391989------1------1-----21-1--------------------1-----------21-1---------------
437928SmithStereoselective, strong inhibi ...Escherichia coliBiochem. Biophys. Res. Commun.162715-7231989------1------2--------1--------------------1--------------1---------------
437942NordlundNew crystal forms of the small ...Escherichia coliFEBS Lett.258251-2541989---1---------1--------1----------------1------------------1---------------
437943ThelanderMolecular cloning and expressi ...Mus musculusEMBO J.82475-24791989--1----------1--------1--------------1--------------------1---------------
437944CarasMolecular cloning of the cDNA ...Mus musculusMol. Cell. Biol.82698-27041988-------------1--------1-----------------------------------1---------------
437929Harder-Characterization of the free r ...Scenedesmus obliquusFEBS Lett.222171-1741987-------------1--------11----------------------------------11--------------
437945RibiTwo-dimensional crystals of en ...Escherichia coliBiochemistry267974-79791987---1---------1--------1----------------1------------------1---------------
437946BunkerExtended X-ray absorption fine ...Escherichia coliBiochemistry264708-47161987--1------1---1--1---1-1--------------1---------1-----1--1-1---------------
437924SaloweCloning, overproduction, and p ...Escherichia coliJ. Bacteriol.165363-3661986--1----------3--1---1-1--------------1---------------1--1-1---------------
437930CoryProtein properties of the subu ...Mus musculusAdv. Enzyme Regul.253-1919862-----6----1-2-----3--2------------2-------6-----1-----3--2---------------
437934SatoDifferential sensitivities of ...Mus musculusArch. Biochem. Biophys.244572-57919861----1-------1-----3--11-----------1-----1-------------3--11--------------
437947ThelanderIsolation and characterization ...Mus musculusMol. Cell. Biol.63433-34421986--1----------1--------1--------------1--------------------1---------------
437950NikasStructural features of ribonuc ...Herpes simplex virusProteins Struct. Funct. Genet.1376-3841986-------------1--------12----------------------------------12--------------
437923SpectorHerpes simplex type 1 ribonucl ...Herpes simplex virusJ. Biol. Chem.2608694-86971985------5------1--------1---------8----------58-------------1---------------
437932Hofmann-Deoxyribonucleotide biosynthes ...Scenedesmus obliquusBiochim. Biophys. Acta83298-11219853-----10----1-1--1-----2111--1------3-------10-----1---1----2111--1---------
437933CoryNucleoside 5'-diphosphates as ...Mus musculusJ. Biol. Chem.26012001-1200719855-----3--1---1-----3--1------------5-------3---1-------3--1---------------
437919HardsRibonucleotide reductase activ ...Mesocricetus auratusArch. Biochem. Biophys.2319-1619845------4-1---3-----1--1------------5---------4-1-------1--1---------------
437920SatoStudies on the differential me ...Mus musculusAdv. Enzyme Regul.22231-2411984------6------1-----1--1--------------------6-----------1--1---------------
437921JoelsonCrystallization and preliminar ...Escherichia coliJ. Biol. Chem.2599076-90771984---1-----