Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system

Yoshikawa, K.; Takei, S.; Hasegawa-Ishii, S.; Chiba, Y.; Furukawa, A.; Kawamura, N.; Hosokawa, M.; Woodward, D.F.; Watanabe, K.; Shimada, A.; Brain Res. 1367, 22-32 (2011)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Commentary (Nat. Sub.)	Natural Products	Commentary (Nat. Pro.)	Organism (Nat. Pro.)	Reversibility
thioredoxin + prostaglandin H2	Mus musculus	-	thioredoxin disulfide + prostaglandin F2alpha	-	-	?
thioredoxin + prostamide H2	Mus musculus	-	thioredoxin disulfide + prostamide F2alpha	-	-	?

Organism

Organism	Primary Accession No. (UniProt)	Commentary	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Commentary	Organism	Textmining
central nervous system	prostamide/PGF synthase is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies	Mus musculus	-
cerebellar cortex	-	Mus musculus	-
medulla oblongata	-	Mus musculus	-
myelin sheath	the enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons	Mus musculus	-
oligodendrocyte	-	Mus musculus	-
pons	-	Mus musculus	-
spinal cord	-	Mus musculus	-
white matter	there is a tendency for the white matter bundles in the spinal cord, medulla oblongata, pons, and cerebellar medulla to express prostamide/PGF synthase more strongly than those in other central nervous system regions	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Commentary Substrates	Literature (Substrates)	Organism	Products	Commentary (Products)	Literature (Products)	Organism (Products)	Reversibility
thioredoxin + prostaglandin H2	-	707934	Mus musculus	thioredoxin disulfide + prostaglandin F2alpha	-	-	-	?
thioredoxin + prostamide H2	-	707934	Mus musculus	thioredoxin disulfide + prostamide F2alpha	-	-	-	?

Cofactor

Cofactor	Commentary	Organism	Structure
thioredoxin	-	Mus musculus

Cofactor (protein specific)

Cofactor	Commentary	Organism	Structure
thioredoxin	-	Mus musculus

Natural Substrates/ Products (Substrates) (protein specific)

Natural Substrates	Organism	Commentary (Nat. Sub.)	Natural Products	Commentary (Nat. Pro.)	Organism (Nat. Pro.)	Reversibility
thioredoxin + prostaglandin H2	Mus musculus	-	thioredoxin disulfide + prostaglandin F2alpha	-	-	?
thioredoxin + prostamide H2	Mus musculus	-	thioredoxin disulfide + prostamide F2alpha	-	-	?

Source Tissue (protein specific)

Source Tissue	Commentary	Organism	Textmining
central nervous system	prostamide/PGF synthase is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies	Mus musculus	-
cerebellar cortex	-	Mus musculus	-
medulla oblongata	-	Mus musculus	-
myelin sheath	the enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons	Mus musculus	-
oligodendrocyte	-	Mus musculus	-
pons	-	Mus musculus	-
spinal cord	-	Mus musculus	-
white matter	there is a tendency for the white matter bundles in the spinal cord, medulla oblongata, pons, and cerebellar medulla to express prostamide/PGF synthase more strongly than those in other central nervous system regions	Mus musculus	-

Substrates and Products (Substrate) (protein specific)

Substrates	Commentary Substrates	Literature (Substrates)	Organism	Products	Commentary (Products)	Literature (Products)	Organism (Products)	Reversibility
thioredoxin + prostaglandin H2	-	707934	Mus musculus	thioredoxin disulfide + prostaglandin F2alpha	-	-	-	?
thioredoxin + prostamide H2	-	707934	Mus musculus	thioredoxin disulfide + prostamide F2alpha	-	-	-	?

Expression

Organism	Commentary	Expression
Mus musculus	the expression of prostamide/PGF synthase in myelin sheaths is age-dependent during the postnatal development, between postnatal days 9 and 14 the expression of the enzyme increases dramatically and preferentially in white matter bundles	up

Expression (protein specific)

Organism	Commentary	Expression
Mus musculus	the expression of prostamide/PGF synthase in myelin sheaths is age-dependent during the postnatal development, between postnatal days 9 and 14 the expression of the enzyme increases dramatically and preferentially in white matter bundles	up

See also following references to EC number 1.11.1.20 (sorted by year of publication):

No.	1st author	Pub Med	title	organims	journal	volume	pages	year	Activating Compound	Application	Cloned(Commentary)	Crystallization (Commentary)	Engineering	General Stability	Inhibitors	KM Value [mM]	Localization	Metals/Ions	Molecular Weight [Da]	Natural Substrates/ Products (Substrates)	Organic Solvent Stability	Organism	Oxidation Stability	Posttranslational Modification	Purification (Commentary)	Reaction	Renatured (Commentary)	Source Tissue	Specific Activity [micromol/min/mg]	Storage Stability	Substrates and Products (Substrate)	Subunits	Temperature Optimum [�C]	Temperature Range [�C]	Temperature Stability [�C]	Turnover Number [1/s]	pH Optimum	pH Range	pH Stability	Cofactor	Ki Value [mM]	pI Value	IC50 Value	Activating Compound (protein specific)	Application (protein specific)	Cloned(Commentary) (protein specific)	Cofactor (protein specific)	Crystallization (Commentary) (protein specific)	Engineering (protein specific)	General Stability (protein specific)	IC50 Value (protein specific)	Inhibitors (protein specific)	Ki Value [mM] (protein specific)	KM Value [mM] (protein specific)	Localization (protein specific)	Metals/Ions (protein specific)	Molecular Weight [Da] (protein specific)	Natural Substrates/ Products (Substrates) (protein specific)	Organic Solvent Stability (protein specific)	Oxidation Stability (protein specific)	Posttranslational Modification (protein specific)	Purification (Commentary) (protein specific)	Renatured (Commentary) (protein specific)	Source Tissue (protein specific)	Specific Activity [micromol/min/mg] (protein specific)	Storage Stability (protein specific)	Substrates and Products (Substrate) (protein specific)	Subunits (protein specific)	Temperature Optimum [�C] (protein specific)	Temperature Range [�C] (protein specific)	Temperature Stability [�C] (protein specific)	Turnover Number [1/s] (protein specific)	pH Optimum (protein specific)	pH Range (protein specific)	pH Stability (protein specific)	pI Value (protein specific)	Expression	General Information	General Information (protein specific)	Expression (protein specific)	KCat/KM [mM/s]	KCat/KM [mM/s] (protein specific)
707934	Yoshikawa		Preferential localization of p ...	Mus musculus	Brain Res.	1367	22-32	2011	-	-	-	-	-	-	-	-	-	-	-	2	-	1	-	-	-	-	-	8	-	-	2	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	2	-	-	-	-	-	8	-	-	2	-	-	-	-	-	-	-	-	-	1	-	-	1	-	-
687797	Moriuchi		Molecular characterization of ...	Mus musculus	J. Biol. Chem.	283	792-801	2008	1	-	1	-	3	-	-	5	1	-	2	-	-	1	-	-	1	-	-	17	-	-	7	-	-	-	-	6	1	-	-	1	-	-	-	1	-	1	1	-	3	-	-	-	-	5	1	-	2	-	-	-	-	1	-	17	-	-	7	-	-	-	-	6	1	-	-	-	-	-	-	-	5	5