Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins

Thomas, J.P.; Geiger, P.G.; Maiorino, M.; Ursini, F.; Girotti, A.W.; Biochim. Biophys. Acta 1045, 252-260 (1990)

 show all sequences of 1.11.1.12

Data extracted from this reference:

Metals/Ions
Metals/Ions Commentary Organism Structure
Se
-
 Sus scrofa
Natural Substrates/ Products (Substrates)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
glutathione + lipid hydroperoxide Sus scrofa role in cellular detoxification of a wide variety of lipid hydroperoxides in membranes and internalized lipoproteins glutathione disulfide + lipid + H2O
-
-
 ?
More Sus scrofa enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes ?
-
-
-
Organism
Organism Primary Accession No. (UniProt) Commentary Textmining
Sus scrofa
-
-
-
Source Tissue
Source Tissue Commentary Organism Textmining
heart
-
 Sus scrofa
-
Substrates and Products (Substrate)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
glutathione + cholesterol hydroperoxides
-
 394870 Sus scrofa ?
-
-
-
 ?
glutathione + lipid hydroperoxide
-
 394870 Sus scrofa glutathione disulfide + lipid + H2O
-
-
-
 ir
glutathione + lipid hydroperoxide role in cellular detoxification of a wide variety of lipid hydroperoxides in membranes and internalized lipoproteins 394870 Sus scrofa glutathione disulfide + lipid + H2O
-
-
-
 ?
More enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes 394870 Sus scrofa ?
-
-
-
-
Metals/Ions (protein specific)
Metals/Ions Commentary Organism Structure
Se
-
 Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates Organism Commentary (Nat. Sub.) Natural Products Commentary (Nat. Pro.) Organism (Nat. Pro.) Reversibility
glutathione + lipid hydroperoxide Sus scrofa role in cellular detoxification of a wide variety of lipid hydroperoxides in membranes and internalized lipoproteins glutathione disulfide + lipid + H2O
-
-
 ?
More Sus scrofa enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes ?
-
-
-
Source Tissue (protein specific)
Source Tissue Commentary Organism Textmining
heart
-
 Sus scrofa
-
Substrates and Products (Substrate) (protein specific)
Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility
glutathione + cholesterol hydroperoxides
-
 394870 Sus scrofa ?
-
-
-
 ?
glutathione + lipid hydroperoxide
-
 394870 Sus scrofa glutathione disulfide + lipid + H2O
-
-
-
 ir
glutathione + lipid hydroperoxide role in cellular detoxification of a wide variety of lipid hydroperoxides in membranes and internalized lipoproteins 394870 Sus scrofa glutathione disulfide + lipid + H2O
-
-
-
 ?
More enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes 394870 Sus scrofa ?
-
-
-
-

See also following references to EC number 1.11.1.12 (sorted by year of publication):
No.1st authorPub
Med		titleorganimsjournalvolumepagesyearActivating CompoundApplicationCloned(Commentary)Crystallization (Commentary)EngineeringGeneral StabilityInhibitorsKM Value [mM]LocalizationMetals/IonsMolecular Weight [Da]Natural Substrates/ Products (Substrates)Organic Solvent StabilityOrganismOxidation StabilityPosttranslational ModificationPurification (Commentary)ReactionRenatured (Commentary)Source TissueSpecific Activity [micromol/min/mg]Storage StabilitySubstrates and Products (Substrate)SubunitsTemperature Optimum [°C]Temperature Range [°C]Temperature Stability [°C]Turnover Number [1/s]pH OptimumpH RangepH StabilityCofactorKi Value [mM]pI ValueIC50 ValueActivating Compound (protein specific)Application (protein specific)Cloned(Commentary) (protein specific)Cofactor (protein specific)Crystallization (Commentary) (protein specific)Engineering (protein specific)General Stability (protein specific)IC50 Value (protein specific)Inhibitors (protein specific)Ki Value [mM] (protein specific)KM Value [mM] (protein specific)Localization (protein specific)Metals/Ions (protein specific)Molecular Weight [Da] (protein specific)Natural Substrates/ Products (Substrates) (protein specific)Organic Solvent Stability (protein specific)Oxidation Stability (protein specific)Posttranslational Modification (protein specific)Purification (Commentary) (protein specific)Renatured (Commentary) (protein specific)Source Tissue (protein specific)Specific Activity [micromol/min/mg] (protein specific)Storage Stability (protein specific)Substrates and Products (Substrate) (protein specific)Subunits (protein specific)Temperature Optimum [°C] (protein specific)Temperature Range [°C] (protein specific)Temperature Stability [°C] (protein specific)Turnover Number [1/s] (protein specific)pH Optimum (protein specific)pH Range (protein specific)pH Stability (protein specific)pI Value (protein specific)ExpressionGeneral InformationGeneral Information (protein specific)Expression (protein specific)KCat/KM [mM/s]KCat/KM [mM/s] (protein specific)
697468HuMolecular characterization of ...Bombus ignitusComp. Biochem. Physiol. B15554-612010--1----2-111-4--1--6--3-1-1-21-1-----11------2-111---1-6--3-1-1-21--1--1--
696173DongEnzymatic properties of a reco ...Momordica charantiaBiochemistry (Moscow)74502-5082009--1----3-111-5--1-----4111--11-1-----11------3-111---1----4111--11--------
696435ConradTransgenic mouse models for th ...Mus musculusBiochim. Biophys. Acta17901575-15852009--------5111-4-----4--21-------1------1-------5111-----4--21--------------
696970BaeModular evolution of glutathio ...animalBMC Evol. Biol.91-132009-1---------1-2--------1--------1----1-1----------1--------1---------------
697470HermeszIdentification of two phosphol ...Cyprinus carpioComp. Biochem. Physiol. C150101-1062009--1------1-1-3-----8--11-------1-----11--------1-1-----8--11--------2--2--
697778KadotaEnhanced metallothionein gene ...Rattus norvegicusEur. J. Pharmacol.626166-1702009--------1--1-2-----1--1--------1------1-------1--1-----1--1---------------
698037Chen-Putative phospholipid hydroper ...Taiwanofungus camphoratusFood Chem.115476-4822009--1-------1--1--1--1--111---1--1-----11---------1----1-1--111---1---------
701033Li-Tissue and induction expressio ...Oryza sativaProg. Biochem. Biophys.3677-8220092------------1-----4--1--------1---2--1----------------4--1---------1--1--
701138DimastrogiovanniCombining crystallography and ...Schistosoma mansoniProteins78259-2702009--112----111-3--1--1--311---1--1-----1112------111---1-1--311---1---------
701272StradaioliPhospholipid hydroperoxide glu ...Bos taurusTheriogenology7291-982009-1-------1-1-3-----48-2-1---1--1----1-1--------1-1-----48-2-1---1---1--1--
686888DabkowskiMitochondria-specific transgen ...Mus musculusFree Radic. Biol. Med.45855-8652008--------2----4-----1--1-----------------------3--------1--1---------------
687186CaiVitellocyte-specific expressio ...Clonorchis sinensisInt. J. Parasitol.381613-16232008--1----------7-----2-----------------4-----------------4------------------
698045GuoSuppression of atherogenesis b ...Homo sapiensFree Radic. Biol. Med.44343-3522008-11------111-3-----1--31----1--1----111--------111-----1--31----1---------
701060KernstockNew strategies for the isolati ...Rattus norvegicusProtein Expr. Purif.62216-2222008----------1--3--1--12-3-------------------------1----1-12-3---------------
701118ZhangCrystal structure of glutathio ...Saccharomyces cerevisiaeProteins Struct. Funct. Genet.731058-10622008--111--------2--1-----1-----1--------1-11------------1----1-----1---------
685185ScheererStructural basis for catalytic ...Homo sapiensBiochemistry469041-90492007--11----1----3-----2---1-------------1-1------1--------2---1--------------
685440ConradPhysiological role of phosphol ...Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofaBiol. Chem.3881019-10252007--------1--2-7-----1--2-----------------------1--2-----1--2---------------
686071WangUrea-induced inactivation and ...Oryza sativaChem. Res. Chin. Univ.23562-5662007--1---------11--1--------------------1------------1--1--------------------
686405PuglisiMice overexpressing the mitoch ...Mus musculusEndocrinology1484302-43092007--1-----5----6-----6-----------------1--------5--------6------------------
686896CejasPhospholipid hydroperoxide glu ...Homo sapiensFree Radic. Res.41681-6872007-1-----------3-----2----------------1------------------2------------------
687471WangPurification and physicochemic ...Oryza sativaJ. Biochem. Mol. Biol.40412-4182007--1----4-----5--1-----4111--11---1---1-------4-------1----4111--11-1------
688464BaekTissue expression and cellular ...Mus musculusJ. Mol. Histol.38237-2442007-------------3-----22-----------------------------------22------------------
688724BaekEffects of endocrine disruptin ...Rattus norvegicusJ. Vet. Sci.8213-2182007-1-----------3-----4----------------1------------------4------------------
688924DingPhospholipid hydroperoxide glu ...Homo sapiensMol. Cancer Ther.61467-14742007-------------3-----9-----------------------------------9------------------
689838ZafiriouBiological role of hepoxilins: ...Rattus norvegicusProstaglandins Leukot. Essent. Fatty Acids77209-2152007-------------2-----1-----------------------------------1------------------
671327DiaconuFailure of phospholipid hydrop ...Homo sapiensAndrologia38152-1572006-------------3-----20-----------------------------------20------------------
672372JanuelPhospholipid-hydroperoxide glu ...Homo sapiensBiochim. Biophys. Acta17611228-12342006------1-3----2--1--24-11-------------------1--3------1-24-11--------------
673807SteinbrennerSelenoprotein P protects endot ...Homo sapiensFree Radic. Res.40936-94320062-----1-1----3-----3--1--------1---2--1----1--1--------3--1---------------
673837DashMolecular characterization of ...Hydra vulgarisGene3811-122006--------2-1--4--------1-----------------------2-1---------1---------------
673845SchneiderEmbryonic expression profile o ...Mus musculusGene Expr. Patterns6489-4942006--------3----3-----18--1-----------------------3--------18--1---------------
673931LiuSuppression of the malignant p ...Homo sapiensHum. Gene Ther.17105-1162006-11-----1----4-----1--1-------------11--------1--------1--1---------------
674370ImaiIdentification of the positive ...Mus musculusJ. Biochem.140573-5902006--------4----3-----13--1-----------------------4--------13--1---------------
674598BorchertThe role of phospholipid hydro ...Mus musculusJ. Biol. Chem.28119655-196642006--------4----4-----2--------------------------4--------2------------------
676554YangA plant mitochondrial phosphol ...Raphanus sativusPlant Mol. Biol.62951-9622006--1-----2-2--5--1--1--3-11--11-1-----11-------2-2----1-1--3-11--11--------
658251NagdasTyrosine phosphorylation gener ...Mesocricetus auratusBiol. Reprod.72164-1712005--------1--1-3-1---1--1-----------------------1--1--1--1--1---------------
658758MaiorinoPrimary structure of the nucle ...Rattus norvegicusFEBS Lett.579667-6702005---------1---3-----3---1-----------------------1-------3---1--------------
671713HattoriInduction of phospholipid hydr ...Homo sapiensBiochem. Biophys. Res. Commun.337464-4732005-------------3-----4-----------------------------------4------------------
671833HattoriUp-regulation of phospholipid ...Rattus norvegicusBiochem. J.389279-2872005-------------3-----3--1--------------------------------3--1---------------
673176PuglisiPHGPx in spermatogenesis: how ...Rattus norvegicusContraception72291-2932005--------4-2--2-----1--------------------------4-2------1------------------
673343LapointeEstrogen selectively up-regula ...Bos taurusEndocrinology1462583-259220051-------1----3-----1--1------------1----------1--------1--1---------------
674008Cossio-BayugarMolecular cloning of a phospho ...Rhipicephalus microplusInsect Biochem. Mol. Biol.351378-13872005---------1---5---------------------------------1--------------------------
674502MaiorinoFunctional interaction of phos ...Rattus norvegicusJ. Biol. Chem.28038395-384022005--------1----2-----110-10--------1------1-------1--------110-10---------------
675048KriskaA thin layer chromatographic m ...Homo sapiensJ. Chromatogr. B82758-642005--1----------2-----1--2--------------1-----------------1--2---------------
675965ConradThe nuclear form of phospholip ...Mus musculusMol. Cell. Biol.257637-76442005--------2----3-----4--------------------------2--------4------------------
658926TramerNative specific activity of gl ...Homo sapiensInt. J. Androl.2788-932004-------------2-----2-----------------------------------2------------------
659398UtomoIdentification of a novel puta ...Homo sapiensJ. Biol. Chem.27943522-435292004--------1--1-3-----10--1-----------------------1--1-----10--1---------------
659647LiPossible function of two insec ...Drosophila melanogaster, Venturia canescensJ. Insect Physiol.491-92003--2--------2-5--2-----5--------------2-----------2---2----5---------------
394877TramerEnzymatic and immunochemical e ...Rattus norvegicusInt. J. Androl.2572-832002--1-----211--3--1--51--1-------------1--------211----1-51--1--------------
658247ForestaMale fertility is linked to th ...Homo sapiensBiol. Reprod.67967-9712002-1-------1-1-3-----2--1-------------1----------1-1-----2--1---------------
658606HerbetteTwo GPX-like proteins from Lyc ...Solanum lycopersicumEur. J. Biochem.2692414-24202002--1----8-----4--------5--------------1-------8------------5---------------
394874AverySaccharomyces cerevisiae expre ...Saccharomyces cerevisiaeJ. Biol. Chem.27633730-337352001--1-11-----1-4--1-----2--------------1--11-------1---1----2---------------
394875WilkinsonBiochemical characterization o ...Trypanosoma cruziBiochem. J.352755-7612000--1----4-----1--1-----6--------------1-------4-------1----6---------------
394879SchnurrBacterial and nonbacterial exp ...Homo sapiensProtein Expr. Purif.19403-4102000--1-1----1-2-4--1--11-3-1--11--------1--1------1-2---1-11-3-1--11---------
394883NomuraMitochondrial phospholipid hyd ...Rattus norvegicusBiochem. J.351183-1932000--1-1---1--2-3-----1--4--------------1--1-----1--2-----1--4---------------
394872Avsian-KretchmerRegulation of stress-induced p ...Citrus sinensisPlanta209469-4771999-----------1-3-----1--2---1----------------------1-----1--2---1-----------
394873SaitoSelenoprotein P in human plasm ...Homo sapiensJ. Biol. Chem.2742866-287119992-------1111-3--11-21-511---1------2----------1111---1-21-511---1---------
394882MaiorinoA selenium-containing phosphol ...Schistosoma mansoniEur. J. Biochem.238838-8441996------1-111--2--1---2-41-------------------1--111----1--2-41--------------
394878ChambersPurification of a cytosolic en ...Homo sapiensInt. J. Biochem.261279-12861994------1-3113-4--1--2528-1--11--------------1--3113---1-2528-1--11---------
394880RoveriPurification and characterizat ...Rattus norvegicusBiochim. Biophys. Acta1208211-2211994-----1--3112-3--1--33-821---1------------1----3112---1-33-821---1---------
394881SattlerReduction of HDL- and LDL-asso ...Sus scrofaArch. Biochem. Biophys.309214-2211994-------------1-----11-3-1---1--------------------------11-3-1---1---------
394876LamPurification of phospholipid h ...Bos taurusCurr. Eye Res.129-151993------12111--3--1--21-41--------1----------112111----1-21-41--------------
394866PanfiliDistribution of glutathione pe ...Rattus norvegicusFEBS Lett.29035-371991--------5----3--1--2--------------------------5------1-2------------------
394867MaiorinoPhospholipid hydroperoxide glu ...Bos taurus, Canis lupus familiaris, Rattus norvegicus, Sus scrofaMethods Enzymol.186448-4571990--------6448-4--11-20213342---4-----------------6448---1-20213342---4---------
394870ThomasEnzymatic reduction of phospho ...Sus scrofaBiochim. Biophys. Acta1045252-2601990---------1-2-2-----1--4------------------------1-2-----1--4---------------
394871ZhangPhospholipid hydroperoxide glu ...Rattus norvegicusBiochim. Biophys. Acta1006140-1431989--------1----3-----61-5-----------------------1--------61-5---------------
394865MaiorinoDifferent effects of Triton X- ...Sus scrofaArch. Biochem. Biophys.251600-60519861-----2----1-2---1-1--6------------1-------2-----1-----1--6---------------
394864UrsiniThe selenoenzyme phospholipid ...Sus scrofaBiochim. Biophys. Acta83962-7019851-----1-111--3--11-11-101----1------1-------1--111----1-11-101----1---------
394868UrsiniPurification from pig liver of ...Sus scrofaBiochim. Biophys. Acta710197-2111982----------12-4--1--24-61--1---------------------12---1-24-61--1-----------
394869Maiorino-A pig heart peroxidation inhib ...Sus scrofaBiochem. Int.5575-5811982-------------1--1--1--1------------------------------1-1--1---------------