EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.31 | 5-aminoimidazole-4-carboxamide ribonucleoside | AICAR, AMPK activator, inhibits Tat-induced HIV-1 transactivation | Homo sapiens | |
2.7.11.31 | resveratrol | reverses Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase activation, inhibits Tat-induced HIV-1 transactivation | Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
2.7.11.31 | drug development | targeting SIRT1-AMPK pathway may serve as a new target for the development of new anti HIV-1 agents | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.31 | 6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine | compound C, potentiates Tat-induced HIV-1 transactivation | Homo sapiens | |
2.7.11.31 | additional information | a significant reduction in AMPK activation and downstream acetyl-CoA carboxylase activation in response to viral Tat protein treatment. Knockdown of SIRT1 by siRNA potentiates Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase activation. Knockdown of AMPK by siRNA potentiates Tat-induced HIV-1 transactivation | Homo sapiens | |
2.7.11.31 | nicotinamide | SIRT1 inhibitor, potentiates Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase activation. Potentiates Tat-induced HIV-1 transactivation | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.31 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.31 | ATP + acetyl-CoA carboxylase | - |
Homo sapiens | ADP + phosphorylated acetyl-CoA carboxylase | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.31 | AMP-activated protein kinase | - |
Homo sapiens |
2.7.11.31 | AMPK | - |
Homo sapiens |