EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.31 | 5-aminoimidazole-4-carboxamide riboside | stimulation of activating AMPK phosphorylation at Thr172 | Rattus norvegicus | |
2.7.11.31 | calyculin A | stimulation of activating AMPK phosphorylation at Thr172, independent of narigin | Rattus norvegicus | |
2.7.11.31 | cantharidin | stimulation of activating AMPK phosphorylation at Thr172, independent of narigin | Rattus norvegicus | |
2.7.11.31 | microcystin-LR | stimulation of activating AMPK phosphorylation at Thr172 | Rattus norvegicus | |
2.7.11.31 | additional information | stimulation by protein phosphatase-inhibitory toxins | Rattus norvegicus | |
2.7.11.31 | okadaic acid | stimulation of activating AMPK phosphorylation at Thr172, activation is antagonized by naringin | Rattus norvegicus | |
2.7.11.31 | tautomycin | stimulation of activating AMPK phosphorylation at Thr172, independent of narigin | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.31 | naringin | inhibits enzyme phosphorylation | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.31 | additional information | Rattus norvegicus | AMPK regulation, AMPK mediates the autophagy suppression of okadaic acid and other protein phosphatase-inhibitory toxins, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.31 | Rattus norvegicus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.11.31 | phosphoprotein | the enzyme is activated by phosphorylation at Thr172, which is inhibited by naringin | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.31 | hepatocyte | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.11.31 | additional information | - |
autophagic activity under different conditions | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.31 | ATP + acetyl-CoA carboxylase | phosphorylation at Ser79 | Rattus norvegicus | ADP + phosphorylated acetyl-CoA carboxylase | - |
? | |
2.7.11.31 | additional information | AMPK regulation, AMPK mediates the autophagy suppression of okadaic acid and other protein phosphatase-inhibitory toxins, overview | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.31 | AMP-activated protein kinase | - |
Rattus norvegicus |
2.7.11.31 | AMPK | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.31 | ATP | - |
Rattus norvegicus |