Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hamilton, S.R.; Stapleton, D.; O'Donnell, J.B.; Kung, J.T.; Dalal, S.R.; Kemp, B.E.; Witters, L.A.
    An activating mutation in the g1 subunit of the AMP-activated protein kinase (2001), FEBS Lett., 500, 163-168.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 5'-AMP
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.31 AMPK heterotrimer expressed in COS7 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.31 R70Q site-directed mutagenesis, marked increase in activity, largely AMP-independent Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.31 ATP + acetyl-CoA carboxylase
-
 Homo sapiens ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.31 heterotrimer
-
 Homo sapiens
2.7.11.31 More heterotrimeric serine/threonine kinase consists of a catalytic alpha-subunit and 2 regulatory subunits beta and gamma, each subunit exists as multiple isoforms, alpha1, alpha2, beta1, beta2, gamma1, gamma2 and gamma3, giving 12 different possible combinantions of holoenzyme with different tissue distribution and subcellular localization Homo sapiens